CD84 Gene
protein-coding GIFtS: 60
GCID: GC01M160510
|
|
CD84 molecule(Previous names: CD84 antigen (leukocyte antigen), CD84 molecule )
| |
Aliases
for CD84 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CD84 Molecule1 2 | | LY9B2 | | SLAMF51 2 3 | | Hly9-Beta1 | | CD84 Antigen (Leukocyte Antigen)1 2 | | Leucocyte Differentiation Antigen CD842 | | HCD841 | | Leukocyte Antigen CD842 | | MCD841 | | SLAM Family Member 52 | | Cell Surface Antigen MAX.32 3 | | Hly9-Beta1 | | Leukocyte Differentiation Antigen CD842 3 | | CD84 Antigen3 | | Signaling Lymphocytic Activation Molecule 52 3 | | |
Export aliases for CD84 gene to outside databasesPrevious GC identifers: GC01M158307 GC01M156248 GC01M157293 GC01M157732 GC01M157328 GC01M158777 GC01M131867 |
Summaries
for CD84 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CD84:
This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM)family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is ahomophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulatingreceptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. (provided byRefSeq, Oct 2011)
UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8Function: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does notseen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes andinduce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitorcells
Gene Wiki entry for CD84
|
Genomic Views
for CD84 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CD84 gene promoter:
GR C/EBPbeta GR-beta POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) IRF-1 POU3F2 PPAR-gamma1 GR-alpha PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CD84
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD84 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q24CD84 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M160510: view genomic region
(about GC identifiers)
Start:
|
160,510,884 bp from pter |
End:
|
160,549,306 bp from pter |
Size:
|
38,423 bases |
Orientation:
|
minus strand |
|
Proteins
for CD84 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8 (See
protein sequence)Recommended Name: SLAM family member 5 precursor Size: 345 amino acids; 38782 Da
Subunit: Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell.Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-proteinphosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A
Subcellular location: Cell membrane; Single-pass type I membrane protein
Developmental stage: Expression is slightly increased in naive B-cells after the first dividion. By contrast,expression on memory B-cells decreased with each successive division
1 PDB 3D structure from  and Proteopedia  for CD84:2PKD (3D)
Secondary accessions: B2R8T1 B7Z3R8 O15430 O95266 O95660 Q5H9R1 Q6FHA8 Q8WLP1 Q8WWI8 Q9UF04 Q9UIB6Q9UIB7 Q9UIT7Alternative splicing: 7 isoforms: Q9UIB8-1 Q9UIB8-2 Q9UIB8-3 Q9UIB8-4 Q9UIB8-5 Q9UIB8-6 Q9UIB8-7 Explore the universe of human proteins at neXtProt for CD84: NX_Q9UIB8
Post-translational modifications:
Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonalantibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domainPhosphorylated on Tyr-296 and Tyr-316 following platelet aggregation1
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UIB8
CD84 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001171808.1 NP_001171810.1 NP_001171811.1 NP_003865.1
ENSEMBL proteins: ENSP00000357033 ENSP00000357027 ENSP00000312367 ENSP00000357030 ENSP00000353163 ENSP00000357026 ENSP00000442845 Reactome Protein details: Q9UIB8
Human Recombinant Protein Products for CD84:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CD84 for ontologies About GeneDecksing
CD84 Antibody Products:
Assay Products for CD84: |
Protein
Domains /
Families
for CD84 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CD84 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UIB8ProtoNet protein and cluster: Q9UIB8 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8Domain: ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1ASimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain |
Function
for CD84 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SLAF5_HUMAN, Q9UIB8Function: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does notseen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes andinduce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitorcells Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- |
CD84 for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cd84):
CD84 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Cd84tm1Pls for CD84
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD84 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD84 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): CD84 (NM_003874) | |  | Sino Biological Human cDNA Clone for CD84 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CD84 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD84 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD84 |
|
Pathways & Interactions
for CD84 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell surface interactions at the vascular wall | | | 2 | Platelet activation, signaling and aggregation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for CD84
CD84 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD84
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for CD84 (Q9UIB82, 3 ENSP000003570334) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CD84 for ontologies About GeneDecksing
|
Drugs & Compounds
for CD84 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CD84 for compounds About GeneDecksing
 Browse Tocris compounds for CD84
1 Novoseek chemical compound relationship for CD84 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
3.72 |
2 |
12928397 (1), 11862385 (1) |
Search CenterWatch for drugs/clinical trials and news about CD84 / SLAF5
|
Transcripts
for CD84 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CD84 gene (4 alternative transcripts): NM_001184879.1 NM_001184881.1 NM_001184882.1 NM_003874.3 Unigene Cluster for CD84: CD84 molecule Hs.398093 [show with all ESTs]Unigene Representative Sequence: NM_0011848798 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368054(uc001fwh.4 uc001fwf.4 uc009wtn.3 uc001fwg.4)
ENST00000466767 ENST00000368048 ENST00000311224 ENST00000368051 ENST00000360056(uc001fwj.3)
ENST00000368047(uc001fwk.3) ENST00000534968(uc001fwi.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD84 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD84 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): CD84 (NM_003874) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CD84 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD84 |
Additional cDNA sequence: AF054815.1 AF054816.1 AF054817.1 AF054818.1 AJ223324.1 AK296290.1 AK313496.1 BC020063.1 CR541847.1 CR933666.1 U82988.1 U96627.1 Y12632.1 12 DOTS entries: DT.40248765 DT.439643 DT.427618 DT.200321 DT.40228916 DT.95362221 DT.99938699 DT.99966727 DT.99981149 DT.97835495 DT.92064777 DT.40126832 24/70 AceView cDNA sequences (see all 70): AW408076 BQ706686 BQ707539 BX118925 BC020063 AU141507 BX498774 H48796 BU899311 AA360585 CK903266 AA477908 Y12632 BM007399 BE504775 BQ712137 AA355777 BU927996 BQ710318 BQ712229 AA687366 BE675295 CR541847 AA938448
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CD84 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CD84
|
Expression
for CD84 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CD84 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGAATTAC
About this image
See CD84 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD84
SOURCE GeneReport for Unigene cluster: Hs.398093
UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8Tissue specificity: Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheralleukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highlyexpressed in memory T-cells
SABiosciences Custom PCR Arrays for CD84
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD84
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD84 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD84 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD84 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD84 |
Orthologs
for CD84 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CD84 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LY96 |
-- |
23(a) |
1 → many |
25(1373488-1374310) |
ENSEMBL Gene Tree for CD84 (if available)
TreeFam Gene Tree for CD84 (if available) |
Paralogs
for CD84 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CD84 gene
- SLAMF92 SLAMF72 SLAMF62 LY92
3 SIMAP similar genes for CD84 using alignment to 3 protein entries: SLAF5_HUMAN (see all proteins):LY9 SLAMF9 SLAMF7
CD84 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CD84
PGOHUM00000241620
|
Genomic Variants
for CD84 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CD84 (160510884 - 160549306 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD84: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD84 |
|
Disorders
/ Diseases
for CD84 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CD84 for disorders About GeneDecksing
OMIM gene information: 604513
OMIM disorders: --
20/28  diseases for CD84 (see all 28): About MalaCardssplenic marginal zone lymphoma allergic contact dermatitis contact dermatitis b-cell lymphomas
dysgammaglobulinemia systemic lupus erythematosus myeloid leukemia lupus erythematosus
acute lymphoblastic leukemia chronic lymphocytic leukemia acute myeloid leukemia chronic myeloid leukemia
lymphoblastic leukemia leukemia lymphocytic leukemia lymphoproliferative syndrome
dermatitis acute leukemia hematopoiesis melanoma
1 disease from the University of Copenhagen DISEASES database for CD84:Dysgammaglobulinemia 6 Novoseek disease relationships for CD84 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia lymphocytic chronic |
39.7 |
1 |
8656688 (1) |
| leukemia |
31.1 |
2 |
17490515 (1), 16005710 (1) |
| lymphoma |
24.6 |
1 |
1728304 (1) |
| acute leukemia |
11.9 |
2 |
12513782 (1) |
| tumors |
0 |
2 |
7680605 (1), 1728304 (1) |
| melanoma |
0 |
2 |
9042204 (1) |
Export disorders for CD84 gene to outside databases
|
Publications
for CD84 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CD84 gene, integrated from 9 sources (see all 101):
(articles sorted by number of sources associating them with CD84) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CD84 leukocyte antigen is a new member of the Ig superfamily. (PubMed id 9310491)1, 2, 3, 9 de la Fuente M.A.... Engel P. (1997)
- Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PubMed id 12928397)1, 2, 9 Tangye S.G.... van de Weerdt B.C.M. (2003)
- CD84 expression on human hematopoietic progenitor cells. (PubMed id 12962726)1, 2, 9 Zaiss M.... Hennemann B. (2003)
- Differential expression of SAP and EAT-2-binding leukocyte cell- surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). (PubMed id 15245368)1, 2, 9 Romero X.... Engel P. (2004)
- Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. (PubMed id 11414741)1, 2, 9 Lewis J.... Duckett C.S. (2001)
- Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains. (PubMed id 10746783)1, 2, 9 Palou E.... Gaya A. (2000)
- Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84. (PubMed id 10698700)1, 2, 9 Krause S.W.... Andreesen R. (2000)
- Structure of CD84 provides insight into SLAM family function. (PubMed id 17563375)1, 2 Yan Q.... Almo S.C. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling. (PubMed id 16037392)1, 2 Nanda N.... Phillips D.R. (2005)
|
External Searches for CD84 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CD84 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CD84 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD84 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CD84 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CD84 gene:
Search GeneIP for patents involving CD84
Licensable Technologies for CD84 gene:GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CD84 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CD84 | | OriGene shRNA RFP for CD84 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD84 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD84 | | | OriGene Protein Over-expression Lysate for CD84 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CD84 | | OriGene 3'-UTR Clone for CD84 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD84 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD84 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CD84 | | OriGene Custom Protein Services for CD84 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD84 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD84 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD84 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD84 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD84 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD84 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CD84 |
| |  |  |  |  | | | | | | Recombinant Protein for CD84 |
|
 |
 |
 |
 | | | CD84 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD84 |
|  |  |  |  | | | | ThermoFisher Antibodies for CD84 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD84 |
| |  | |
|
|
|
