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Aliases for CD84 Gene

Aliases for CD84 Gene

  • CD84 Molecule 2 3
  • Signaling Lymphocytic Activation Molecule 5 3 4
  • Leukocyte Differentiation Antigen CD84 3 4
  • CD84 Antigen (Leukocyte Antigen) 2 3
  • Cell Surface Antigen MAX.3 3 4
  • Hly9-Beta 3 4
  • SLAMF5 3 4
  • Leucocyte Differentiation Antigen CD84 3
  • Leukocyte Antigen CD84 3
  • SLAM Family Member 5 3
  • CD84 Antigen 4
  • HCD84 3
  • MCD84 3
  • LY9B 3

External Ids for CD84 Gene

Previous GeneCards Identifiers for CD84 Gene

  • GC01M158307
  • GC01M156248
  • GC01M157293
  • GC01M157732
  • GC01M157328
  • GC01M158777
  • GC01M131867

Summaries for CD84 Gene

Entrez Gene Summary for CD84 Gene

  • This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

GeneCards Summary for CD84 Gene

CD84 (CD84 Molecule) is a Protein Coding gene. Diseases associated with CD84 include dysgammaglobulinemia. Among its related pathways are Hemostasis and Cell surface interactions at the vascular wall. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF6.

UniProtKB/Swiss-Prot for CD84 Gene

  • Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.

Gene Wiki entry for CD84 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD84 Gene

Genomics for CD84 Gene

Genomic Location for CD84 Gene

Start:
160,541,094 bp from pter
End:
160,579,516 bp from pter
Size:
38,423 bases
Orientation:
Minus strand

Genomic View for CD84 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD84 Gene

Proteins for CD84 Gene

  • Protein details for CD84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIB8-SLAF5_HUMAN
    Recommended name:
    SLAM family member 5
    Protein Accession:
    Q9UIB8
    Secondary Accessions:
    • B2R8T1
    • B7Z3R8
    • O15430
    • O95266
    • O95660
    • Q5H9R1
    • Q6FHA8
    • Q8WLP1
    • Q8WWI8
    • Q9UF04
    • Q9UIB6
    • Q9UIB7
    • Q9UIT7

    Protein attributes for CD84 Gene

    Size:
    345 amino acids
    Molecular mass:
    38782 Da
    Quaternary structure:
    • Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A.

    Three dimensional structures from OCA and Proteopedia for CD84 Gene

    Alternative splice isoforms for CD84 Gene

neXtProt entry for CD84 Gene

Proteomics data for CD84 Gene at MOPED

Post-translational modifications for CD84 Gene

  • N-glycosylated.
  • Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domain Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation.
  • Ubiquitination at Lys122, Lys303, and Lys308
  • Glycosylation at Asn146, Asn150, and Asn201
  • Modification sites at PhosphoSitePlus

Other Protein References for CD84 Gene

No data available for DME Specific Peptides for CD84 Gene

Domains for CD84 Gene

Gene Families for CD84 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for CD84 Gene

Suggested Antigen Peptide Sequences for CD84 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIB8

UniProtKB/Swiss-Prot:

SLAF5_HUMAN :
  • Q9UIB8
Domain:
  • ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD84: view

Function for CD84 Gene

Molecular function for CD84 Gene

UniProtKB/Swiss-Prot Function: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.

Gene Ontology (GO) - Molecular Function for CD84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding IPI 12928397
genes like me logo Genes that share ontologies with CD84: view

Phenotypes for CD84 Gene

genes like me logo Genes that share phenotypes with CD84: view

Animal Models for CD84 Gene

MGI Knock Outs for CD84:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD84 Gene

Localization for CD84 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD84 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD84 Gene COMPARTMENTS Subcellular localization image for CD84 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9310491
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CD84: view

Pathways for CD84 Gene

genes like me logo Genes that share pathways with CD84: view

Pathways by source for CD84 Gene

Gene Ontology (GO) - Biological Process for CD84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 9310491
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules TAS 7797269
GO:0007596 blood coagulation TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with CD84: view

Compounds for CD84 Gene

(1) Novoseek inferred chemical compound relationships for CD84 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 3.72 2

(1) PharmGKB related drug/compound annotations for CD84 Gene

Drug/compound Annotation
etanercept CA
genes like me logo Genes that share compounds with CD84: view

Transcripts for CD84 Gene

Unigene Clusters for CD84 Gene

CD84 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD84 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for CD84 Gene

GeneLoc Exon Structure for
CD84
ECgene alternative splicing isoforms for
CD84

Expression for CD84 Gene

mRNA expression in normal human tissues for CD84 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD84 Gene

This gene is overexpressed in Spleen (5.7) and Whole Blood (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CD84 Gene

SOURCE GeneReport for Unigene cluster for CD84 Gene Hs.398093

mRNA Expression by UniProt/SwissProt for CD84 Gene

Q9UIB8-SLAF5_HUMAN
Tissue specificity: Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells.
genes like me logo Genes that share expressions with CD84: view

Orthologs for CD84 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD84 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD84 35
  • 99.49 (n)
  • 98.78 (a)
CD84 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD84 35
  • 82.52 (n)
  • 71.04 (a)
CD84 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD84 35
  • 78.9 (n)
  • 67.58 (a)
CD84 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd84 35
  • 75.26 (n)
  • 59.63 (a)
Cd84 16
Cd84 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd84 35
  • 73.22 (n)
  • 57.29 (a)
Species with no ortholog for CD84:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD84 Gene

ENSEMBL:
Gene Tree for CD84 (if available)
TreeFam:
Gene Tree for CD84 (if available)

Paralogs for CD84 Gene

Paralogs for CD84 Gene

Selected SIMAP similar genes for CD84 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CD84 Gene

genes like me logo Genes that share paralogs with CD84: view

Variants for CD84 Gene

Sequence variations from dbSNP and Humsavar for CD84 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs349248 -- 160,566,503(+) TTTTG(C/T)TCCAG intron-variant
rs349249 -- 160,571,668(+) GGGGG(C/T)TGGGG intron-variant
rs872405 -- 160,567,662(+) CAACA(C/T)GATGA intron-variant
rs872406 -- 160,567,768(+) AAATT(C/T)AAGAA intron-variant
rs872407 -- 160,567,398(+) TTCCC(G/T)TAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD84 Gene

Variant ID Type Subtype PubMed ID
nsv872491 CNV Loss 21882294
nsv831703 CNV Gain 17160897

Relevant External Links for CD84 Gene

HapMap Linkage Disequilibrium report
CD84

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD84 Gene

Disorders for CD84 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CD84 Gene including...

Search for CD84 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CD84 Gene

(6) Novoseek inferred disease relationships for CD84 Gene

Disease -log(P) Hits PubMed IDs
leukemia lymphocytic chronic 39.7 1
leukemia 31.1 2
lymphoma 24.6 1
acute leukemia 11.9 1
tumors 0 2
genes like me logo Genes that share disorders with CD84: view

No data available for UniProtKB/Swiss-Prot for CD84 Gene

Publications for CD84 Gene

  1. CD84 leukocyte antigen is a new member of the Ig superfamily. (PMID: 9310491) de la Fuente M.A. … Engel P. (Blood 1997) 2 3 4 23
  2. Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84. (PMID: 10698700) Krause S.W. … Andreesen R. (Biochem. J. 2000) 3 4 23
  3. Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains. (PMID: 10746783) Palou E. … Gaya A. (Tissue Antigens 2000) 3 4 23
  4. Differential expression of SAP and EAT-2-binding leukocyte cell- surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). (PMID: 15245368) Romero X. … Engel P. (Tissue Antigens 2004) 3 4 23
  5. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PMID: 12928397) Tangye S.G. … van de Weerdt B.C.M. (J. Immunol. 2003) 3 4 23

Products for CD84 Gene

  • Addgene plasmids for CD84

Sources for CD84 Gene

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