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Aliases for CD84 Gene

Aliases for CD84 Gene

  • CD84 Molecule 2 3 5
  • Signaling Lymphocytic Activation Molecule 5 3 4
  • Leukocyte Differentiation Antigen CD84 3 4
  • CD84 Antigen (Leukocyte Antigen) 2 3
  • Cell Surface Antigen MAX.3 3 4
  • Hly9-Beta 3 4
  • SLAMF5 3 4
  • Leucocyte Differentiation Antigen CD84 3
  • Leukocyte Antigen CD84 3
  • CD84 Antigen 4
  • HCD84 3
  • MCD84 3
  • LY9B 3

External Ids for CD84 Gene

Previous GeneCards Identifiers for CD84 Gene

  • GC01M158307
  • GC01M156248
  • GC01M157293
  • GC01M157732
  • GC01M157328
  • GC01M158777
  • GC01M131867

Summaries for CD84 Gene

Entrez Gene Summary for CD84 Gene

  • This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

GeneCards Summary for CD84 Gene

CD84 (CD84 Molecule) is a Protein Coding gene. Diseases associated with CD84 include transient hypogammaglobulinemia of infancy and transient hypogammaglobulinemia. Among its related pathways are Platelet activation, signaling and aggregation and IgA-Producing B Cells in the Intestine. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF6.

UniProtKB/Swiss-Prot for CD84 Gene

  • Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).

Gene Wiki entry for CD84 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD84 Gene

Genomics for CD84 Gene

Regulatory Elements for CD84 Gene

Promoters for CD84 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD84 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD84 Gene

Chromosome:
1
Start:
160,541,094 bp from pter
End:
160,579,516 bp from pter
Size:
38,423 bases
Orientation:
Minus strand

Genomic View for CD84 Gene

Genes around CD84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD84 Gene

Proteins for CD84 Gene

  • Protein details for CD84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIB8-SLAF5_HUMAN
    Recommended name:
    SLAM family member 5
    Protein Accession:
    Q9UIB8
    Secondary Accessions:
    • B2R8T1
    • B7Z3R8
    • O15430
    • O95266
    • O95660
    • Q5H9R1
    • Q6FHA8
    • Q8WLP1
    • Q8WWI8
    • Q9UF04
    • Q9UIB6
    • Q9UIB7
    • Q9UIT7

    Protein attributes for CD84 Gene

    Size:
    345 amino acids
    Molecular mass:
    38782 Da
    Quaternary structure:
    • Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/EAT-2. Interacts with tyrosine-protein phosphatases PTPN6/SHP-1 and PTPN11//SHP-2 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A. Interacts (via phosphorylated ITSM 1 and 2) with INPP5D/SHIP1.

    Three dimensional structures from OCA and Proteopedia for CD84 Gene

    Alternative splice isoforms for CD84 Gene

neXtProt entry for CD84 Gene

Proteomics data for CD84 Gene at MOPED

Post-translational modifications for CD84 Gene

  • N-glycosylated.
  • Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A is dependent of tyrosine phosphorylation of its cytoplasmic domain. Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation. Phosphorylated on tyrosine residues upon high affinity immunoglobulin epsilon receptor aggregation in mast cells.
  • Ubiquitination at Lys 122, Lys 303, and Lys 308
  • Glycosylation at Asn 150 and Asn 201
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CD84 Gene

Domains & Families for CD84 Gene

Protein Domains for CD84 Gene

Suggested Antigen Peptide Sequences for CD84 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UIB8

UniProtKB/Swiss-Prot:

SLAF5_HUMAN :
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A three-pronged mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Domain:
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containingbinding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A three-pronged mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD84: view

Function for CD84 Gene

Molecular function for CD84 Gene

UniProtKB/Swiss-Prot Function:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).
genes like me logo Genes that share phenotypes with CD84: view

Animal Models for CD84 Gene

MGI Knock Outs for CD84:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD84

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD84 Gene

Localization for CD84 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD84 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD84 Gene COMPARTMENTS Subcellular localization image for CD84 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CD84: view

Pathways & Interactions for CD84 Gene

genes like me logo Genes that share pathways with CD84: view

Pathways by source for CD84 Gene

Gene Ontology (GO) - Biological Process for CD84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules TAS 7797269
GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production IDA 22068234
GO:0032701 negative regulation of interleukin-18 production IDA 22068234
GO:0033004 negative regulation of mast cell activation IDA 22068234
genes like me logo Genes that share ontologies with CD84: view

No data available for SIGNOR curated interactions for CD84 Gene

Drugs & Compounds for CD84 Gene

(2) Drugs for CD84 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Etanercept Approved, Investigational Pharma 383
genes like me logo Genes that share compounds with CD84: view

Transcripts for CD84 Gene

Unigene Clusters for CD84 Gene

CD84 molecule:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD84 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - - -
SP5: -
SP6:
SP7:

Relevant External Links for CD84 Gene

GeneLoc Exon Structure for
CD84
ECgene alternative splicing isoforms for
CD84

Expression for CD84 Gene

mRNA expression in normal human tissues for CD84 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD84 Gene

This gene is overexpressed in Spleen (x5.7) and Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for CD84 Gene

This gene is overexpressed in Urine (20.5), Peripheral blood mononuclear cells (18.2), Platelet (17.6), and Serum (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD84 Gene



SOURCE GeneReport for Unigene cluster for CD84 Gene Hs.398093

mRNA Expression by UniProt/SwissProt for CD84 Gene

Q9UIB8-SLAF5_HUMAN
Tissue specificity: Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast cells.
genes like me logo Genes that share expression patterns with CD84: view

Protein tissue co-expression partners for CD84 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CD84 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD84 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD84 35
  • 82.52 (n)
  • 71.04 (a)
CD84 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD84 35
  • 78.9 (n)
  • 67.58 (a)
CD84 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd84 35
  • 75.26 (n)
  • 59.63 (a)
Cd84 16
Cd84 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD84 35
  • 99.49 (n)
  • 98.78 (a)
CD84 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd84 35
  • 73.22 (n)
  • 57.29 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
ManyToMany
Species with no ortholog for CD84:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD84 Gene

ENSEMBL:
Gene Tree for CD84 (if available)
TreeFam:
Gene Tree for CD84 (if available)

Paralogs for CD84 Gene

Paralogs for CD84 Gene

(3) SIMAP similar genes for CD84 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CD84 Gene

genes like me logo Genes that share paralogs with CD84: view

Variants for CD84 Gene

Sequence variations from dbSNP and Humsavar for CD84 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs349249 -- 160,571,668(+) GGGGG(C/T)TGGGG intron-variant
rs977018 -- 160,579,942(-) CCCCA(C/T)CGCCA upstream-variant-2KB
rs977019 -- 160,579,933(-) CATTC(A/G)CCTAA upstream-variant-2KB
rs977020 -- 160,579,789(-) GCTTA(C/T)TACAT upstream-variant-2KB
rs1466932 -- 160,578,937(+) GATAA(C/T)GATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD84 Gene

Variant ID Type Subtype PubMed ID
nsv872491 CNV Loss 21882294
nsv831703 CNV Gain 17160897

Variation tolerance for CD84 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD84 Gene

HapMap Linkage Disequilibrium report
CD84

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD84 Gene

Disorders for CD84 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CD84 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search CD84 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD84

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD84
genes like me logo Genes that share disorders with CD84: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD84 Gene

Publications for CD84 Gene

  1. CD84 leukocyte antigen is a new member of the Ig superfamily. (PMID: 9310491) de la Fuente M.A. … Engel P. (Blood 1997) 2 3 4 23 67
  2. Differential expression of SAP and EAT-2-binding leukocyte cell- surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). (PMID: 15245368) Romero X. … Engel P. (Tissue Antigens 2004) 3 23
  3. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PMID: 12928397) Tangye S.G. … van de Weerdt B.C.M. (J. Immunol. 2003) 3 23
  4. CD84 expression on human hematopoietic progenitor cells. (PMID: 12962726) Zaiss M. … Hennemann B. (Exp. Hematol. 2003) 3 23
  5. Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. (PMID: 11414741) Lewis J. … Duckett C.S. (Clin. Immunol. 2001) 3 23

Products for CD84 Gene

Sources for CD84 Gene

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