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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD84 Gene

protein-coding   GIFtS: 59
GCID: GC01M160510

CD84 Molecule

(Previous names: CD84 antigen (leukocyte antigen), CD84 molecule )
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD84 Molecule1 2     hly9-beta2
CD84 Antigen (Leukocyte Antigen)1 2     Leucocyte Differentiation Antigen CD842
Cell Surface Antigen MAX.32 3     Leukocyte Antigen CD842
Leukocyte Differentiation Antigen CD842 3     mCD842
Signaling Lymphocytic Activation Molecule 52 3     SLAM Family Member 52
SLAMF52 3     Hly9-beta3
LY9B2     CD84 Antigen3
hCD842     

External Ids:    HGNC: 17041   Entrez Gene: 88322   Ensembl: ENSG000000662947   OMIM: 6045135   UniProtKB: Q9UIB83   

Export aliases for CD84 gene to outside databases

Previous GC identifers: GC01M158307 GC01M156248 GC01M157293 GC01M157732 GC01M157328 GC01M158777 GC01M131867


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD84 Gene:
This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM)
family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is
a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating
receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. (provided
by RefSeq, Oct 2011)

GeneCards Summary for CD84 Gene: 
CD84 (CD84 molecule) is a protein-coding gene. Diseases associated with CD84 include dysgammaglobulinemia, and splenic marginal zone lymphoma, and among its related super-pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF9.

UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8
Function: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2
domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does
not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in
lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for
hematopoietic progenitor cells

Gene Wiki entry for CD84 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD84 gene promoter:
         GR   C/EBPbeta   GR-beta   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   IRF-1   POU3F2   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD84 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD84

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD84


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q24

CD84 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD84 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160510:  view genomic region     (about GC identifiers)

Start:
160,510,884 bp from pter      End:
160,549,306 bp from pter
Size:
38,423 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8 (See protein sequence)
Recommended Name: SLAM family member 5 precursor  
Size: 345 amino acids; 38782 Da
Subunit: Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another
cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein
phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by
SH2D1A
Subcellular location: Cell membrane; Single-pass type I membrane protein
Developmental stage: Expression is slightly increased in naive B-cells after the first dividion. By contrast,
expression on memory B-cells decreased with each successive division
1 PDB 3D structure from and Proteopedia for CD84:
2PKD (3D)    
Secondary accessions: B2R8T1 B7Z3R8 O15430 O95266 O95660 Q5H9R1 Q6FHA8 Q8WLP1 Q8WWI8 Q9UF04
Q9UIB6 Q9UIB7 Q9UIT7
Alternative splicing: 7 isoforms:  Q9UIB8-1   Q9UIB8-2   Q9UIB8-3   Q9UIB8-4   Q9UIB8-5   Q9UIB8-6   Q9UIB8-7   

Explore the universe of human proteins at neXtProt for CD84: NX_Q9UIB8

Explore proteomics data for CD84 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist
    monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic
    domain Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation
  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UIB8

  • CD84 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD84 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001171808.1  NP_001171810.1  NP_001171811.1  NP_003865.1  

    ENSEMBL proteins: 
     ENSP00000357033   ENSP00000357027   ENSP00000312367   ENSP00000357030   ENSP00000442845  
    Reactome Protein details: Q9UIB8
    Human Recombinant Protein Products for CD84: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD84 (CD84/SLAMF5)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CD84
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CD84
    GenScript Custom Purified and Recombinant Proteins Services for CD84
    Novus Biologicals CD84 Proteins
    Novus Biologicals CD84 Lysates
    Sino Biological Recombinant Protein for CD84
    Sino Biological Cell Lysate for CD84 
    ProSpec Recombinant Protein for CD84
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9310491

    CD84 for ontologies           About GeneDecksing



    CD84 Antibody Products: 
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    Novus Biologicals CD84 Antibodies
    Abcam antibodies for CD84
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CD84
    LSBio Antibodies in human, mouse, rat for CD84 

    Assay Products for CD84: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD84
    R&D Systems Proteome Profiler Antibody Arrays for CD84 (CD84/SLAMF5)
    GenScript Custom Assay Services for CD84
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR015631 SLAM_fam_rcpts
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9UIB8

    ProtoNet protein and cluster: Q9UIB8

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8
    Domain: ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    CD84 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAF5_HUMAN, Q9UIB8
    Function: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2
    domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does
    not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in
    lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for
    hematopoietic progenitor cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding IPI12928397
         
    CD84 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd84):
     hematopoietic system  immune system 

    CD84 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd84tm1Pls for CD84

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD84 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD84

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD84 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD84 

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CD84 (see all 14):
    hsa-miR-2052 hsa-miR-4264 hsa-miR-142-3p hsa-miR-1197 hsa-miR-4328 hsa-miR-561 hsa-miR-1285 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidCD84 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD84
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD84

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CD84
    Sirion Biotech Customized adenovirus for overexpression of CD84

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD84 (see all 20)
    OriGene ORF clones in mouse, rat for CD84
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CD84 (NM_003874)
    Sino Biological Human cDNA Clone for CD84
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD84
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD84
    Sirion Biotech Customized lentivirus for stable overexpression of CD84 
                         Customized lentivirus expression plasmids for stable overexpression of CD84 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CD84
    Search LifeMap BioReagents cell lines for CD84
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD84


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD84 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Platelet activation, signaling and aggregation
    Hemostasis0.43
    2Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2        Reactome Pathways for CD84
        Hemostasis
    Cell surface interactions at the vascular wall



    CD84 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD84

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CD84 (Q9UIB82, 3 ENSP000003570334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2D1BO147962, 3, ENSP000003569064MINT-8026176 MINT-8028807 I2D: score=3 STRING: ENSP00000356906
    SH2D1AO608802, 3, ENSP000003601814MINT-8026187 MINT-8031954 I2D: score=5 STRING: ENSP00000360181
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    WDR37ENSP000002631504STRING: ENSP00000263150
    --ENSP000003293434STRING: ENSP00000329343
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS9310491
    GO:0007156homophilic cell adhesion TAS7797269
    GO:0007596blood coagulation TAS--
    GO:0050900leukocyte migration TAS--

    CD84 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD84 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD84 (SLAF5)

    1 Novoseek inferred chemical compound relationship for CD84 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 3.72 2 12928397 (1), 11862385 (1)

    Search CenterWatch for drugs/clinical trials and news about CD84 / SLAF5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD84 gene (4 alternative transcripts): 
    NM_001184879.1  NM_001184881.1  NM_001184882.1  NM_003874.3  

    Unigene Cluster for CD84:

    CD84 molecule
    Hs.398093  [show with all ESTs]
    Unigene Representative Sequence: NM_001184879
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368054(uc001fwh.4 uc001fwf.4 uc009wtn.3 uc001fwg.4)
    ENST00000466767 ENST00000368048 ENST00000311224 ENST00000368051 ENST00000360056(uc001fwj.3)
    ENST00000368047(uc001fwk.3) ENST00000534968(uc001fwi.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD84
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CD84 (see all 14):
    hsa-miR-2052 hsa-miR-4264 hsa-miR-142-3p hsa-miR-1197 hsa-miR-4328 hsa-miR-561 hsa-miR-1285 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidCD84 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD84
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD84
    Clone
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    OriGene clones in human, mouse for CD84 (see all 20)
    OriGene ORF clones in mouse, rat for CD84
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CD84 (NM_003874)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD84
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD84
    Sirion Biotech Customized lentivirus for stable overexpression of CD84 
                         Customized lentivirus expression plasmids for stable overexpression of CD84 
    Primer
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    OriGene qPCR primer pairs and template standards for CD84
    OriGene qSTAR qPCR primer pairs in human, mouse for CD84
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD84
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD84

    Additional mRNA sequence: 

    AF054815.1 AF054816.1 AF054817.1 AF054818.1 AJ223324.1 AK296290.1 AK313496.1 BC020063.1 
    CR541847.1 CR933666.1 U82988.1 U96627.1 Y12632.1 

    12 DOTS entries:

    DT.40248765  DT.439643  DT.427618  DT.200321  DT.40228916  DT.95362221  DT.99938699  DT.99966727 
    DT.99981149  DT.97835495  DT.92064777  DT.40126832 

    24/70 AceView cDNA sequences (see all 70):

    AW408076 BQ706686 BQ707539 H48796 AU141507 BC020063 BX498774 BU899311 
    BX118925 AA360585 AA355777 BE504775 BQ712137 BQ710318 AF054815 U96627 
    AI421666 BU429718 AW013969 AL597403 AA687366 NM_003874 CK903266 AA477908 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CD84 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                    -           -     -           -                           
    SP2:                    -                 -           -                           
    SP3:                    -           -     -     -     -                           
    SP4:                    -           -     -     -     -     -                     
    SP5:                    -                                                         


    ECgene alternative splicing isoforms for CD84

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD84 expression in normal human tissues (normalized intensities)      CD84 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGAATTAC
    CD84 Expression
    About this image


    CD84 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
             monocyte-derived dendritic cells   
     
     Lung (Respiratory System)
             alveolar macrophages   
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros

    See CD84 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD84

    SOURCE GeneReport for Unigene cluster: Hs.398093

    UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8
    Tissue specificity: Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral
    leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells.
    Highly expressed in memory T-cells

        SABiosciences Custom PCR Arrays for CD84
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    OriGene qSTAR qPCR primer pairs in human, mouse for CD84
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD84
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD84
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD84

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD84 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd841 , 5 CD84 antigen1, 5 74.87(n)1
    58.97(a)1
      1 (79.54 cM)5
    125231  NM_013489.31  NP_038517.11 
     1718396975 
    chicken
    (Gallus gallus)
    Aves --
    --
    22(a)
    1 → many
    25(1223442-1225768)


    ENSEMBL Gene Tree for CD84 (if available)
    TreeFam Gene Tree for CD84 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD84 gene
    SLAMF92  SLAMF72  SLAMF62  LY92  
    3 SIMAP similar genes for CD84 using alignment to 3 protein entries:     SLAF5_HUMAN (see all proteins):
    LY9    SLAMF9    SLAMF7

    CD84 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD84
    PGOHUM00000241620


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1029 SNPs in CD84 are shown (see all 1029)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115676041,2
    C,F--160510453(+) TAGGCA/GTTGGC 4 -- int11Minor allele frequency- G:0.01NA 120
    rs1131549281,2
    C,F--160510459(+) TTGGCT/CCCTGT 4 -- int11Minor allele frequency- C:0.01NA 120
    rs1475938901,2
    --160510556(+) TTTCCC/TCTCTC 4 -- int10--------
    rs1406696361,2
    --160510575(+) CCAAGA/GCAGAA 4 -- int10--------
    rs1500899101,2
    --160510620(+) CCCTCC/TGGGTT 4 -- int10--------
    rs730163761,2
    C,F--160510621(+) CCTCCG/AGGTTT 4 -- int13Minor allele frequency- A:0.06WA EA 240
    rs1116163981,2
    C,F--160510641(+) CTGGCA/GTTTGT 4 -- int12Minor allele frequency- G:0.04CSA WA 119
    rs343785341,2
    C,F--160510652(+) CCTTCC/TTGTCT 4 -- int14Minor allele frequency- T:0.08NA 126
    rs559772901,2
    C,F--160510689(+) CCCAAT/CCATCT 4 -- int13Minor allele frequency- C:0.08WA CSA 122
    rs1842941731,2
    --160510702(+) CTACAC/TCAGCT 4 -- int10--------

    HapMap Linkage Disequilibrium report for CD84 (160510884 - 160549306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD84:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv872491CNV Loss21882294
    nsv831703CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604513    OMIM disorders: --

    20/23 diseases for CD84 (see all 23):    About MalaCards
    dysgammaglobulinemia    splenic marginal zone lymphoma    contact dermatitis    allergic contact dermatitis
    hematopoietic stem cell transplantation    acute leukemia    b-cell chronic lymphocytic leukemia    dermatitis
    chronic myeloid leukemia    acute myeloid leukemia    myeloid leukemia    acute lymphoblastic leukemia
    lymphoblastic leukemia    b-cell lymphomas    leukemia    chronic lymphocytic leukemia
    t-cell leukemia    systemic lupus erythematosus    melanoma    lupus erythematosus

    1 disease from the University of Copenhagen DISEASES database for CD84:
    Dysgammaglobulinemia

    CD84 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for CD84 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 39.7 1 8656688 (1)
    leukemia 31.1 2 17490515 (1), 16005710 (1)
    lymphoma 24.6 1 1728304 (1)
    acute leukemia 11.9 2 12513782 (1)
    tumors 0 2 7680605 (1), 1728304 (1)
    melanoma 0 2 9042204 (1)


    Export disorders for CD84 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD84 gene, integrated from 9 sources (see all 102):
    (articles sorted by number of sources associating them with CD84)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD84 leukocyte antigen is a new member of the Ig superfamily. (PubMed id 9310491)1, 2, 3, 9 de la Fuente M.A.... Engel P. (1997)
    2. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PubMed id 12928397)1, 2, 9 Tangye S.G.... van de Weerdt B.C.M. (2003)
    3. CD84 expression on human hematopoietic progenitor cells. (PubMed id 12962726)1, 2, 9 Zaiss M.... Hennemann B. (2003)
    4. Differential expression of SAP and EAT-2-binding leukocyte cell- surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). (PubMed id 15245368)1, 2, 9 Romero X.... Engel P. (2004)
    5. Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. (PubMed id 11414741)1, 2, 9 Lewis J.... Duckett C.S. (2001)
    6. Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains. (PubMed id 10746783)1, 2, 9 Palou E.... Gaya A. (2000)
    7. Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84. (PubMed id 10698700)1, 2, 9 Krause S.W.... Andreesen R. (2000)
    8. Structure of CD84 provides insight into SLAM family function. (PubMed id 17563375)1, 2 Yan Q.... Almo S.C. (2007)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling. (PubMed id 16037392)1, 2 Nanda N.... Phillips D.R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8832 HGNC: 1704 AceView: CD84 Ensembl:ENSG00000066294 euGenes: HUgn8832
    ECgene: CD84 H-InvDB: CD84

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD84 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD84 gene:
    Search GeneIP for patents involving CD84

    Licensable Technologies for CD84 gene:
    Weizmann Institute:Regulation of B-CLL survival (CD74 and CD84 as regulators in tumor cells)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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