Aliases for CD84 Gene
External Ids for CD84 Gene
Previous GeneCards Identifiers for CD84 Gene
This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
GeneCards Summary for CD84 Gene
CD84 (CD84 Molecule) is a Protein Coding gene. Diseases associated with CD84 include transient hypogammaglobulinemia of infancy and transient hypogammaglobulinemia. Among its related pathways are Hemostasis and Cell surface interactions at the vascular wall. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF6.
UniProtKB/Swiss-Prot for CD84 Gene
Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.