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CD84 Gene

protein-coding   GIFtS: 60
GCID: GC01M160510

CD84 Molecule

(Previous names: CD84 antigen (leukocyte antigen), CD84 molecule )
  See CD84-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD84 Molecule1 2     hly9-beta2
CD84 Antigen (Leukocyte Antigen)1 2     Leucocyte Differentiation Antigen CD842
Cell Surface Antigen MAX.32 3     Leukocyte Antigen CD842
Leukocyte Differentiation Antigen CD842 3     mCD842
Signaling Lymphocytic Activation Molecule 52 3     SLAM Family Member 52
SLAMF52 3     Hly9-beta3
LY9B2     CD84 Antigen3
hCD842     

External Ids:    HGNC: 17041   Entrez Gene: 88322   Ensembl: ENSG000000662947   OMIM: 6045135   UniProtKB: Q9UIB83   

Export aliases for CD84 gene to outside databases

Previous GC identifers: GC01M158307 GC01M156248 GC01M157293 GC01M157732 GC01M157328 GC01M158777 GC01M131867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD84 Gene:
This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM)
family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is
a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating
receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. (provided
by RefSeq, Oct 2011)

GeneCards Summary for CD84 Gene:
CD84 (CD84 molecule) is a protein-coding gene. Diseases associated with CD84 include dysgammaglobulinemia. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF9.

UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8
Function: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2
domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does
not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in
lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for
hematopoietic progenitor cells

Gene Wiki entry for CD84 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD84 gene promoter:
         GR   C/EBPbeta   GR-beta   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   IRF-1   POU3F2   PPAR-gamma1   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD84 promoter sequence
   Search Chromatin IP Primers for CD84

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD84


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q24

CD84 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD84 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160510:  view genomic region     (about GC identifiers)

Start:
160,510,884 bp from pter      End:
160,549,306 bp from pter
Size:
38,423 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8 (See protein sequence)
Recommended Name: SLAM family member 5 precursor  
Size: 345 amino acids; 38782 Da
Subunit: Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another
cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein
phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by
SH2D1A
Developmental stage: Expression is slightly increased in naive B-cells after the first dividion. By contrast,
expression on memory B-cells decreased with each successive division
1 PDB 3D structure from and Proteopedia for CD84:
2PKD (3D)    
Secondary accessions: B2R8T1 B7Z3R8 O15430 O95266 O95660 Q5H9R1 Q6FHA8 Q8WLP1 Q8WWI8 Q9UF04
Q9UIB6 Q9UIB7 Q9UIT7
Alternative splicing: 7 isoforms:  Q9UIB8-1   Q9UIB8-2   Q9UIB8-3   Q9UIB8-4   Q9UIB8-5   Q9UIB8-6   Q9UIB8-7   

Explore the universe of human proteins at neXtProt for CD84: NX_Q9UIB8

Explore proteomics data for CD84 at MOPED

Post-translational modifications: 

  • Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist
    monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic
    domain Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation1
  • N-glycosylated1
  • Ubiquitination2 at Lys122, Lys303, Lys308
  • Glycosylation2 at Asn146, Asn150, Asn201
  • Modification sites at PhosphoSitePlus

  • See CD84 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001171808.1  NP_001171810.1  NP_001171811.1  NP_003865.1  

    ENSEMBL proteins: 
     ENSP00000357033   ENSP00000357027   ENSP00000312367   ENSP00000357030   ENSP00000442845  
    Reactome Protein details: Q9UIB8

    CD84 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD84
    OriGene Protein Over-expression Lysate for CD84
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CD84
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    Novus Biologicals CD84 Proteins
    Novus Biologicals CD84 Lysates
    Sino Biological Recombinant Protein for CD84
    Sino Biological Cell Lysate for CD84
    ProSpec Recombinant Protein for CD84
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD84 

    CD84 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CD84 Antibodies
    Abcam antibodies for CD84
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CD84
    LSBio Antibodies in human, mouse, rat for CD84

    CD84 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CD84 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR015631 SLAM_fam_rcpts
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9UIB8

    ProtoNet protein and cluster: Q9UIB8

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8
    Domain: ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    Find genes that share domains with CD84           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAF5_HUMAN, Q9UIB8
    Function: Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2
    domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does
    not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in
    lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for
    hematopoietic progenitor cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding IPI12928397
         
    Find genes that share ontologies with CD84           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd84):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CD84           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cd84tm1Pls for CD84

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD84
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD84

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD84
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD84

    miRNA
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    Block miRNA regulation of human, mouse, rat CD84 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD84 (see all 14):
    hsa-miR-2052 hsa-miR-4264 hsa-miR-142-3p hsa-miR-1197 hsa-miR-4328 hsa-miR-561 hsa-miR-1285 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidCD84 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CD84
    Predesigned siRNA for gene silencing in human, mouse, rat CD84

    Gene Editing
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    OriGene ORF clones in mouse, rat for CD84
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CD84 (NM_003874)
    Sino Biological Human cDNA Clone for CD84
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD84
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD84

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CD84 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD84


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLAF5_HUMAN, Q9UIB8: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9310491

    Find genes that share ontologies with CD84           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD84 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall


    Find genes that share SuperPaths with CD84           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CD84
        Cell surface interactions at the vascular wall


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD84
    Interactions:

        GeneGlobe Interaction Network for CD84

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CD84 (Q9UIB81, 2, 3 ENSP000003570334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2D1BO147961, 2, 3, ENSP000003569064EBI-6691679,EBI-3923013 MINT-8026176 MINT-8028807 I2D: score=3 STRING: ENSP00000356906
    SH2D1AO608802, 3, ENSP000003601814MINT-8026187 MINT-8031954 I2D: score=5 STRING: ENSP00000360181
    PTPN11Q061243, ENSP000003409444I2D: score=1 STRING: ENSP00000340944
    WDR37ENSP000002631504STRING: ENSP00000263150
    --ENSP000003293434STRING: ENSP00000329343
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS9310491
    GO:0007156homophilic cell adhesion TAS7797269
    GO:0007596blood coagulation TAS--
    GO:0050900leukocyte migration TAS--

    Find genes that share ontologies with CD84           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD84 (SLAF5)

    1 Novoseek inferred chemical compound relationship for CD84 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 3.72 2 12928397 (1), 11862385 (1)

    1 PharmGKB related drug/compound annotation for CD84 gene    About this table
    Drug/compound PharmGKB Annotation
    etanerceptCA  



    Find genes that share compounds with CD84           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD84 gene (4 alternative transcripts): 
    NM_001184879.1  NM_001184881.1  NM_001184882.1  NM_003874.3  

    Unigene Cluster for CD84:

    CD84 molecule
    Hs.398093  [show with all ESTs]
    Unigene Representative Sequence: NM_001184879
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368054(uc001fwh.4 uc001fwf.4 uc009wtn.3 uc001fwg.4)
    ENST00000466767 ENST00000368048 ENST00000311224 ENST00000368051 ENST00000360056(uc001fwj.3)
    ENST00000368047(uc001fwk.3) ENST00000534968(uc001fwi.4)
    miRNA
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    Block miRNA regulation of human, mouse, rat CD84 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD84 (see all 14):
    hsa-miR-2052 hsa-miR-4264 hsa-miR-142-3p hsa-miR-1197 hsa-miR-4328 hsa-miR-561 hsa-miR-1285 hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidCD84 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD84
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    GenScript: all cDNA clones in your preferred vector (see all 4): CD84 (NM_003874)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD84
      QuantiTect SYBR Green Assays in human, mouse, rat CD84
      QuantiFast Probe-based Assays in human, mouse, rat CD84

    Additional mRNA sequence: 

    AF054815.1 AF054816.1 AF054817.1 AF054818.1 AJ223324.1 AK296290.1 AK313496.1 BC020063.1 
    CR541847.1 CR933666.1 U82988.1 U96627.1 Y12632.1 

    12 DOTS entries:

    DT.40248765  DT.439643  DT.427618  DT.200321  DT.40228916  DT.95362221  DT.99938699  DT.99966727 
    DT.99981149  DT.97835495  DT.92064777  DT.40126832 

    Selected AceView cDNA sequences (see all 70):

    AU141507 BC020063 BX118925 BX498774 H48796 BU899311 BQ707539 BQ706686 
    AW408076 AF054817 NM_003874 BQ712229 AI421666 AJ223324 BX103535 U96627 
    AA687366 AA360585 AA477908 BM007399 AA938448 BE675295 AL597403 BE504775 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD84 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                    -           -     -           -                           
    SP2:                    -                 -           -                           
    SP3:                    -           -     -     -     -                           
    SP4:                    -           -     -     -     -     -                     
    SP5:                    -                                                         


    ECgene alternative splicing isoforms for CD84

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD84 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGAATTAC
    CD84 Expression
    About this image


    CD84 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    CD84 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD84 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.398093

    UniProtKB/Swiss-Prot: SLAF5_HUMAN, Q9UIB8
    Tissue specificity: Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral
    leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells.
    Highly expressed in memory T-cells

        Custom PCR Arrays for CD84
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    QuantiFast Probe-based Assays in human, mouse, rat CD84
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD84

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD84 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd841 , 5 CD84 antigen1, 5 75.26(n)1
    59.63(a)1
      1 (79.54 cM)5
    125231  NM_013489.31  NP_038517.11 
     1718396975 


    ENSEMBL Gene Tree for CD84 (if available)
    TreeFam Gene Tree for CD84 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD84 gene
    SLAMF92  SLAMF72  SLAMF62  LY92  
    3 SIMAP similar genes for CD84 using alignment to 3 protein entries:     SLAF5_HUMAN (see all proteins):
    LY9    SLAMF9    SLAMF7

    Find genes that share paralogs with CD84           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CD84
    PGOHUM00000241620


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CD84 (see all 1029)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115676041,2
    C,F--160510453(+) TAGGCA/GTTGGC 4 -- int11Minor allele frequency- G:0.01NA 120
    rs1131549281,2
    C,F--160510459(+) TTGGCT/CCCTGT 4 -- int11Minor allele frequency- C:0.01NA 120
    rs1475938901,2
    --160510556(+) TTTCCC/TCTCTC 4 -- int10--------
    rs1406696361,2
    --160510575(+) CCAAGA/GCAGAA 4 -- int10--------
    rs1500899101,2
    --160510620(+) CCCTCC/TGGGTT 4 -- int10--------
    rs730163761,2
    C,F--160510621(+) CCTCCG/AGGTTT 4 -- int13Minor allele frequency- A:0.06WA EA 240
    rs1116163981,2
    C,F--160510641(+) CTGGCA/GTTTGT 4 -- int12Minor allele frequency- G:0.04CSA WA 119
    rs343785341,2
    C,F--160510652(+) CCTTCC/TTGTCT 4 -- int14Minor allele frequency- T:0.08NA 126
    rs559772901,2
    C,F--160510689(+) CCCAAT/CCATCT 4 -- int13Minor allele frequency- C:0.08WA CSA 122
    rs1842941731,2
    --160510702(+) CTACAC/TCAGCT 4 -- int10--------

    HapMap Linkage Disequilibrium report for CD84 (160510884 - 160549306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD84:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872491CNV Loss21882294
    nsv831703CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD84
    DNA2.0 Custom Variant and Variant Library Synthesis for CD84

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604513    OMIM disorders: --

    1 disease for CD84:    
    About MalaCards
    dysgammaglobulinemia

    1 disease from the University of Copenhagen DISEASES database for CD84:
    Dysgammaglobulinemia

    Find genes that share disorders with CD84           About GenesLikeMe

    6 Novoseek inferred disease relationships for CD84 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 39.7 1 8656688 (1)
    leukemia 31.1 2 17490515 (1), 16005710 (1)
    lymphoma 24.6 1 1728304 (1)
    acute leukemia 11.9 2 12513782 (1)
    tumors 0 2 7680605 (1), 1728304 (1)
    melanoma 0 2 9042204 (1)


    Export disorders for CD84 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD84 gene, integrated from 10 sources (see all 102):
    (articles sorted by number of sources associating them with CD84)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD84 leukocyte antigen is a new member of the Ig superfamily. (PubMed id 9310491)1, 2, 3, 9 de la Fuente M.A.... Engel P. (Blood 1997)
    2. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PubMed id 12928397)1, 2, 9 Tangye S.G.... van de Weerdt B.C.M. (J. Immunol. 2003)
    3. CD84 expression on human hematopoietic progenitor cells. (PubMed id 12962726)1, 2, 9 Zaiss M.... Hennemann B. (Exp. Hematol. 2003)
    4. Differential expression of SAP and EAT-2-binding leukocyte cell- surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). (PubMed id 15245368)1, 2, 9 Romero X.... Engel P. (Tissue Antigens 2004)
    5. Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. (PubMed id 11414741)1, 2, 9 Lewis J.... Duckett C.S. (Clin. Immunol. 2001)
    6. Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains. (PubMed id 10746783)1, 2, 9 Palou E.... Gaya A. (Tissue Antigens 2000)
    7. Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84. (PubMed id 10698700)1, 2, 9 Krause S.W.... Andreesen R. (Biochem. J. 2000)
    8. Structure of CD84 provides insight into SLAM family function. (PubMed id 17563375)1, 2 Yan Q.... Almo S.C. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling. (PubMed id 16037392)1, 2 Nanda N.... Phillips D.R. (Blood 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8832 HGNC: 1704 AceView: CD84 Ensembl:ENSG00000066294 euGenes: HUgn8832
    ECgene: CD84 H-InvDB: CD84

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD84 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD84 gene:
    Search GeneIP for patents involving CD84

    Licensable Technologies for CD84 gene:
    Weizmann Institute:Regulation of B-CLL survival (CD74 and CD84 as regulators in tumor cells)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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