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Aliases for CD83 Gene

Aliases for CD83 Gene

  • CD83 Molecule 2 3
  • CD83 Antigen (Activated B Lymphocytes, Immunoglobulin Superfamily) 2 3
  • Cell Surface Protein HB15 3 4
  • B-Cell Activation Protein 3 4
  • CD83 Antigen 3 4
  • HCD83 3 4
  • BL11 3 6
  • HB15 3 6
  • Cell-Surface Glycoprotein 3

External Ids for CD83 Gene

Summaries for CD83 Gene

Entrez Gene Summary for CD83 Gene

  • The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for CD83 Gene

CD83 (CD83 Molecule) is a Protein Coding gene. Among its related pathways are B cell receptor signaling pathway (KEGG).

UniProtKB/Swiss-Prot for CD83 Gene

  • May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation

Gene Wiki entry for CD83 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD83 Gene

Genomics for CD83 Gene

Genomic Location for CD83 Gene

Start:
14,117,256 bp from pter
End:
14,136,918 bp from pter
Size:
19,663 bases
Orientation:
Plus strand

Genomic View for CD83 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD83 Gene

Regulatory Elements for CD83 Gene

Proteins for CD83 Gene

  • Protein details for CD83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01151-CD83_HUMAN
    Recommended name:
    CD83 antigen
    Protein Accession:
    Q01151
    Secondary Accessions:
    • Q5THX9

    Protein attributes for CD83 Gene

    Size:
    205 amino acids
    Molecular mass:
    23042 Da
    Quaternary structure:
    • Monomer

neXtProt entry for CD83 Gene

Proteomics data for CD83 Gene at MOPED

Post-translational modifications for CD83 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn79, Asn86, Asn96, and Asn117

Other Protein References for CD83 Gene

No data available for DME Specific Peptides for CD83 Gene

Domains for CD83 Gene

Gene Families for CD83 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD83 Gene

Suggested Antigen Peptide Sequences for CD83 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01151

UniProtKB/Swiss-Prot:

CD83_HUMAN
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q01151
genes like me logo Genes that share domains with CD83: view

Function for CD83 Gene

Molecular function for CD83 Gene

GENATLAS Biochemistry: cell differentiation antigen precursor CD83 dendritic cell marker,recognized by monoclonal antibody HB15,expressed in langerhans cells
UniProtKB/Swiss-Prot Function: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation

Gene Ontology (GO) - Molecular Function for CD83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CD83: view

Phenotypes for CD83 Gene

genes like me logo Genes that share phenotypes with CD83: view

Animal Models for CD83 Gene

MGI Knock Outs for CD83:

miRNA for CD83 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD83 Gene

Localization for CD83 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD83 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD83 Gene COMPARTMENTS Subcellular localization image for CD83 gene
Compartment Confidence
plasma membrane 4
extracellular 2
lysosome 2
nucleus 2
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9310491
GO:0005887 integral component of plasma membrane TAS 8422464
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CD83: view

Pathways for CD83 Gene

SuperPathways for CD83 Gene

genes like me logo Genes that share pathways with CD83: view

Pathways by source for CD83 Gene

1 BioSystems pathway for CD83 Gene

Interacting Proteins for CD83 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368450%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000425561%0d%0a
Selected Interacting proteins: ENSP00000368450 for CD83 Gene via STRING

Gene Ontology (GO) - Biological Process for CD83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response TAS 1378080
GO:0006959 humoral immune response TAS 8422464
GO:0007165 signal transduction TAS 9310491
GO:0014070 response to organic cyclic compound IEA --
GO:0032713 negative regulation of interleukin-4 production IEA --
genes like me logo Genes that share ontologies with CD83: view

Compounds for CD83 Gene

(10) Novoseek inferred chemical compound relationships for CD83 Gene

Compound -log(P) Hits PubMed IDs
polyinosinic-polycytidylic acid 41 1
mannose 34.8 4
dextran 21.3 1
calcitriol 21.2 1
pge2 19.7 2
genes like me logo Genes that share compounds with CD83: view

Transcripts for CD83 Gene

Unigene Clusters for CD83 Gene

CD83 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD83 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for CD83 Gene

GeneLoc Exon Structure for
CD83
ECgene alternative splicing isoforms for
CD83

Expression for CD83 Gene

mRNA expression in normal human tissues for CD83 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CD83 Gene Hs.595133

mRNA Expression by UniProt/SwissProt for CD83 Gene

Q01151-CD83_HUMAN
Tissue specificity: Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells
genes like me logo Genes that share expressions with CD83: view

No data available for mRNA differential expression in normal tissues and Protein expression for CD83 Gene

Orthologs for CD83 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD83 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD83 35
  • 99.35 (n)
  • 99.51 (a)
CD83 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD83 35
  • 80.98 (n)
  • 76.26 (a)
CD83 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD83 35
  • 81.03 (n)
  • 72.82 (a)
CD83 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd83 35
  • 75.65 (n)
  • 69.95 (a)
Cd83 16
Cd83 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD83 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd83 35
  • 75.47 (n)
  • 70.47 (a)
chicken
(Gallus gallus)
Aves CD83 35
  • 52.69 (n)
  • 43.11 (a)
CD83 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD83 36
  • 27 (a)
OneToOne
Species with no ortholog for CD83:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD83 Gene

ENSEMBL:
Gene Tree for CD83 (if available)
TreeFam:
Gene Tree for CD83 (if available)

Paralogs for CD83 Gene

Pseudogenes.org Pseudogenes for CD83 Gene

genes like me logo Genes that share paralogs with CD83: view

No data available for Paralogs for CD83 Gene

Variants for CD83 Gene

Sequence variations from dbSNP and Humsavar for CD83 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1526 -- 14,136,478(+) CGAAG(C/T)GTTGC utr-variant-3-prime
rs9230 -- 14,136,783(+) TACAA(C/T)GAACC utr-variant-3-prime
rs853357 -- 14,129,399(+) AGTTT(A/G)TGGTT intron-variant
rs853358 -- 14,131,013(+) TTCGC(A/T)GGAGG intron-variant
rs853359 -- 14,134,103(+) AGAGG(C/T)CCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD83 Gene

Variant ID Type Subtype PubMed ID
esv271358 CNV Insertion 20981092

Relevant External Links for CD83 Gene

HapMap Linkage Disequilibrium report
CD83

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD83 Gene

Disorders for CD83 Gene

(2) University of Copenhagen DISEASES for CD83 Gene

(8) Novoseek inferred disease relationships for CD83 Gene

Disease -log(P) Hits PubMed IDs
necrosis 46.7 6
tumors 32.7 7
granuloma 10.1 1
colitis ulcerative 6.93 2
inflammation 3.97 1

Relevant External Links for CD83

Genetic Association Database (GAD)
CD83
Human Genome Epidemiology (HuGE) Navigator
CD83
genes like me logo Genes that share disorders with CD83: view

No data available for UniProtKB/Swiss-Prot for CD83 Gene

Publications for CD83 Gene

  1. A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. (PMID: 1378080) Zhou L.-J. … Tedder T.F. (J. Immunol. 1992) 2 3 4 23
  2. Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes. (PMID: 8422464) Kozlow E.J. … Kehrl J.H. (Blood 1993) 2 3 4
  3. Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease. (PMID: 12594843) te Velde A.A. … Vyth-Dreese F.A. (Eur. J. Immunol. 2003) 3 23
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CD83 Gene

Sources for CD83 Gene

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