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CD83 Gene

protein-coding   GIFtS: 63
GCID: GC06P014117

CD83 Molecule

(Previous names: CD83 antigen (activated B lymphocytes, immunoglobulin superfamily),...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD83 Molecule1 2     hCD832 3
CD83 Antigen (Activated B Lymphocytes, Immunoglobulin Superfamily)1 2     BL112 5
Cell Surface Protein HB152 3     HB152 5
B-Cell Activation Protein2 3     Cell-Surface Glycoprotein2
CD83 Antigen2 3     

External Ids:    HGNC: 17031   Entrez Gene: 93082   Ensembl: ENSG000001121497   OMIM: 6045345   UniProtKB: Q011513   

Export aliases for CD83 gene to outside databases

Previous GC identifers: GC06P014175 GC06P014225 GC06P014063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD83 Gene:
The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin
superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A
soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for CD83 Gene:
CD83 (CD83 molecule) is a protein-coding gene. Diseases associated with CD83 include epidermodysplasia verruciformis, and chronic mucocutaneous candidiasis.

UniProtKB/Swiss-Prot: CD83_HUMAN, Q01151
Function: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte
activation

Gene Wiki entry for CD83 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD83 gene promoter:
         FOXF2   AML1a   Olf-1   MIF-1   LCR-F1   Evi-1   S8   POU2F1   POU2F1a   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD83 promoter sequence
   Search Chromatin IP Primers for CD83

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD83


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p23   Ensembl cytogenetic band:  6p23   HGNC cytogenetic band: 6p23

CD83 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD83 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P014117:  view genomic region     (about GC identifiers)

Start:
14,117,865 bp from pter      End:
14,137,149 bp from pter
Size:
19,285 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD83_HUMAN, Q01151 (See protein sequence)
Recommended Name: CD83 antigen precursor  
Size: 205 amino acids; 23042 Da
Subunit: Monomer
Secondary accessions: Q5THX9

Explore the universe of human proteins at neXtProt for CD83: NX_Q01151

Explore proteomics data for CD83 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn79, Asn86, Asn96, Asn117
  • Modification sites at PhosphoSitePlus

  • See CD83 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035370.1  NP_001238830.1  NP_004224.1  

    ENSEMBL proteins: 
     ENSP00000368450  

    CD83 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CD83
    OriGene Protein Over-expression Lysate for CD83
    OriGene MassSpec for CD83
    OriGene Custom Protein Services for CD83
    GenScript Custom Purified and Recombinant Proteins Services for CD83
    Novus Biologicals CD83 Proteins
    Novus Biologicals CD83 Lysates
    Sino Biological Recombinant Protein for CD83
    Sino Biological Cell Lysate for CD83
    ProSpec Recombinant Protein for CD83
    Cloud-Clone Corp. Proteins for CD83

    CD83 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD83
    R&D Systems Antibodies for CD83
    OriGene Antibodies for CD83
    OriGene Custom Antibody Services for CD83
    Novus Biologicals CD83 Antibodies
    Abcam antibodies for CD83
    Cloud-Clone Corp. Antibodies for CD83
    ThermoFisher Antibodies for CD83
    LSBio Antibodies in human, mouse, rat for CD83

    CD83 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD83
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD83
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD83
    Cloud-Clone Corp. CLIAs for CD83


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q01151

    ProtoNet protein and cluster: Q01151

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: CD83_HUMAN, Q01151
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD83 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD83_HUMAN, Q01151
    Function: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte
    activation

         Genatlas biochemistry entry for CD83:
    cell differentiation antigen precursor CD83 dendritic cell marker,recognized by monoclonal antibody HB15,expressed
    in langerhans cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CD83 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD83:
     Increased G2M DNA content  S arrest 

         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cd83):
     hematopoietic system  immune system  normal 

    CD83 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd83tm1Tft for CD83

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD83
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD83

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD83
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD83

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD83:
    hsa-mir-192-5p (MIRT026759), hsa-mir-215-5p (MIRT024870), hsa-mir-122-5p (MIRT023390), hsa-mir-373-3p (MIRT002516)

    Block miRNA regulation of human, mouse, rat CD83 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD83 (see all 22):
    hsa-miR-520f hsa-miR-607 hsa-miR-4311 hsa-miR-137 hsa-miR-1260b hsa-miR-944 hsa-miR-1285 hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidCD83 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD83
    Predesigned siRNA for gene silencing in human, mouse, rat CD83

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD83

    Clone
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    OriGene clones in human, mouse for CD83 (see all 12)
    OriGene ORF clones in mouse, rat for CD83
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD83 (NM_004233)
    Sino Biological Human cDNA Clone for CD83
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD83
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD83

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CD83
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD83 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD83


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD83_HUMAN, Q01151: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    lysosome2
    nucleus2
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9310491
    GO:0005887integral component of plasma membrane TAS8422464
    GO:0009897external side of plasma membrane IEA--

    CD83 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD83 About    
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    TCR Signaling Pathway0.36


    1 BioSystems Pathway for CD83
        TCR Signaling Pathway



        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD83: 
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antifungal Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD83

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CD83 (ENSP000003684504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4EENSP000002808924STRING: ENSP00000280892
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS1378080
    GO:0006959humoral immune response TAS8422464
    GO:0007165signal transduction TAS9310491
    GO:0014070response to organic cyclic compound IEA--
    GO:0032713negative regulation of interleukin-4 production IEA--

    CD83 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD83

    10 Novoseek inferred chemical compound relationships for CD83 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyinosinic-polycytidylic acid 41 1 17063122 (1)
    mannose 34.8 4 10679076 (1), 12930919 (1), 16567867 (1), 9348319 (1)
    dextran 21.3 1 16567867 (1)
    calcitriol 21.2 1 10812248 (1)
    pge2 19.7 2 9348319 (2)
    allergens 17 2 17118622 (1)
    cyclosporin a 15.3 1 12429717 (1)
    dexamethasone 5.09 1 16293609 (1)
    paraffin 0 2 15983979 (1), 17347328 (1)
    cycloheximide 0 3 9278308 (1), 15320871 (1)



    CD83 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD83 gene (3 alternative transcripts): 
    NM_001040280.1  NM_001251901.1  NM_004233.3  

    Unigene Cluster for CD83:

    CD83 molecule
    Hs.595133  [show with all ESTs]
    Unigene Representative Sequence: NM_004233
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000379153(uc021ylz.1 uc003nbh.3 uc003nbi.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD83 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD83 (see all 22):
    hsa-miR-520f hsa-miR-607 hsa-miR-4311 hsa-miR-137 hsa-miR-1260b hsa-miR-944 hsa-miR-1285 hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidCD83 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD83
    Predesigned siRNA for gene silencing in human, mouse, rat CD83
    Clone
    Products:
         
    OriGene clones in human, mouse for CD83 (see all 12)
    OriGene ORF clones in mouse, rat for CD83
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD83 (NM_004233)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD83
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD83
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD83
    OriGene qSTAR qPCR primer pairs in human, mouse for CD83
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD83
      QuantiTect SYBR Green Assays in human, mouse, rat CD83
      QuantiFast Probe-based Assays in human, mouse, rat CD83

    Additional mRNA sequence: 

    AK223315.1 AK290426.1 AK307059.1 AK309541.1 BC004351.1 BC030830.1 BT019498.1 CR457019.1 
    Z11697.1 

    9 DOTS entries:

    DT.446014  DT.121355111  DT.97766391  DT.75181606  DT.95373724  DT.95378116  DT.121355115  DT.121355146 
    DT.99999359 

    Selected AceView cDNA sequences (see all 155):

    AI983994 AA491205 AA291329 CR605061 AA385462 BM981159 AA649188 CB143145 
    CA310401 BU170587 CD368478 BQ004638 CR600901 CA306332 AA490713 AI357087 
    AI344754 BQ049162 AW768445 CA308967 CD368794 BM996479 AI382045 BM673188 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD83 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:        -     -     -           -           -                                 
    SP2:                    -           -           -                                 
    SP3:                    -           -           -                                 
    SP4:                                -           -                                 
    SP5:                    -           -                                             


    ECgene alternative splicing isoforms for CD83

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD83 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTAAAAT
    CD83 Expression
    About this image


    CD83 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Mature B-Cells Peripheral Blood
             Mature dendritic-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Bone Marrow
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Renal Vesicle
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
    CD83 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD83 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.595133

    UniProtKB/Swiss-Prot: CD83_HUMAN, Q01151
    Tissue specificity: Expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD83: 
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antifungal Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD83
    OriGene qSTAR qPCR primer pairs in human, mouse for CD83
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD83
    QuantiTect SYBR Green Assays in human, mouse, rat CD83
    QuantiFast Probe-based Assays in human, mouse, rat CD83
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD83

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD83 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd831 , 5 CD83 antigen1, 5 75.65(n)1
    69.95(a)1
      13 (21.60 cM)5
    125221  NM_009856.21  NP_033986.11 
     437851075 
    chicken
    (Gallus gallus)
    Aves CD831 CD83 molecule 52.69(n)
    43.11(a)
      420838  XM_418929.4  XP_418929.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD836
    CD83 molecule
    27(a)
    1 ↔ 1
    4(57295743-57310356)


    ENSEMBL Gene Tree for CD83 (if available)
    TreeFam Gene Tree for CD83 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD83 gene

    CD83 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD83
    PGOHUM00000243094


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD83 (see all 488)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94765061,2
    C,F,A--14037894(+) ggaagG/Aaaatg 1 -- us2k13Minor allele frequency- A:0.05CSA WA 122
    rs1448127851,2
    --14038038(+) AAGATA/TTCATA 1 -- us2k10--------
    rs1832682971,2
    --14038068(+) ATCTTA/GAACTT 1 -- us2k10--------
    rs77387971,2
    C,F--14038163(+) ATGAAT/GGACAA 1 -- us2k18Minor allele frequency- G:0.28NA WA CSA EA 368
    rs1152201931,2
    --14038170(+) ACAATC/GCTCAG 1 -- us2k10--------
    rs1484236101,2
    --14038432(+) GCTGAA/GGGGAG 3 -- us2k10--------
    rs94646591,2
    C,F--14038564(+) AACTGG/AAAAGA 3 -- us2k12Minor allele frequency- A:0.33CSA 3
    rs77543081,2
    C,F--14038699(+) gcgggC/Atcctg 3 -- us2k13Minor allele frequency- A:0.33NA WA 6
    rs1888681131,2
    --14038719(+) CTACTC/TGGGAG 3 -- us2k10--------
    rs1114986541,2
    C,F--14038776(+) AAGCTG/CAGATC 3 -- us2k12Minor allele frequency- C:0.00CSA 2

    HapMap Linkage Disequilibrium report for CD83 (14117865 - 14137149 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CD83:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271358CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD83
    DNA2.0 Custom Variant and Variant Library Synthesis for CD83

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604534    OMIM disorders: --

    Selected diseases for CD83 (see all 52):    
    About MalaCards
    epidermodysplasia verruciformis    chronic mucocutaneous candidiasis    oral lichen planus    candidiasis
    t cell deficiency    common variable immunodeficiency    lichen planus    hepatitis e
    dermatomyositis    autoimmune thyroiditis    tetanus    anaplastic large cell lymphoma
    papillary carcinoma    measles    celiac disease    ulcerative colitis
    chronic myeloid leukemia    dermatitis    gastritis    graves' disease

    2 diseases from the University of Copenhagen DISEASES database for CD83:
    Tetanus     Leukemia

    CD83 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    8 Novoseek inferred disease relationships for CD83 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 46.7 6 17636246 (1), 17063122 (1), 17347328 (1), 19037923 (1) (see all 6)
    tumors 32.7 7 19580370 (1), 17636246 (1), 17063122 (1), 17301951 (1) (see all 7)
    granuloma 10.1 1 15948122 (1)
    colitis ulcerative 6.93 2 11474315 (1), 19376560 (1)
    inflammation 3.97 1 19702851 (1)
    dermatitis atopic 0 1 12631251 (1)
    metastasis 0 1 15983979 (1)
    melanoma 0 2 15983979 (1), 18221542 (1)

    Genetic Association Database (GAD): CD83
    Human Genome Epidemiology (HuGE) Navigator: CD83 (4 documents)

    Export disorders for CD83 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD83 gene, integrated from 10 sources (see all 207):
    (articles sorted by number of sources associating them with CD83)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily. (PubMed id 1378080)1, 2, 3, 9 Zhou L.-J.... Tedder T.F. (J. Immunol. 1992)
    2. Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes. (PubMed id 8422464)1, 2, 3 Kozlow E.J.... Kehrl J.H. (Blood 1993)
    3. CD83 gene polymorphisms increase susceptibility to human invasive cervical cancer. (PubMed id 18056445)1, 4 Zhang Z....Rader J.S. (Cancer Res. 2007)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells. (PubMed id 15320871)1, 9 Cao W....Lu J. (Biochem. J. 2005)
    7. Latent membrane protein 1 of Epstein-Barr virus induces CD83 by the NF-kappaB signaling pathway. (PubMed id 12857898)1, 9 Dudziak D....Bornkamm G.W. (J. Virol. 2003)
    8. The mouse Cd83 gene: structure, domain organization, and chromosome localization. (PubMed id 9799334)1, 9 Twist C.J....Tedder T.F. (Immunogenetics 1998)
    9. Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease. (PubMed id 12594843)1, 9 te Velde A.A....Vyth-Dreese F.A. (Eur. J. Immunol. 2003)
    10. Altered expressions of peripheral CD11c, CD80, CD83 markers and associations of HLA class II allele and haplotypes in self-limiting Hepatitis E infection. (PubMed id 23246582)1 Das R....Tripathy A.S. (Hum. Immunol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9308 HGNC: 1703 AceView: CD83 Ensembl:ENSG00000112149 euGenes: HUgn9308
    ECgene: CD83 H-InvDB: CD83

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD83 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Other_00148

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD83 gene:
    Search GeneIP for patents involving CD83

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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