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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD82 Gene

protein-coding   GIFtS: 61
GCID: GC11P044586

CD82 Molecule

(Previous names: kangai 1 (suppression of tumorigenicity 6, prostate; CD82...)
(Previous symbols: ST6, KAI1)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD82 Molecule1 2     R2 Leukocyte Antigen1
KAI11 2 3 5     Suppression Of Tumorigenicity 61
ST61 2 3 5     4F92
CD82 Antigen1 2 3     C332
SAR22 3 5     GR152
Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2
Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4))1 2
     R22
Inducible Membrane Protein R22 3     tetraspanin-272
Metastasis Suppressor Kangai-12 3     tspan-272
IA42 3     Tetraspanin-273
TSPAN272 3     Tspan-273
C33 Antigen2 3     Suppressor Of Tumorigenicity 6 Protein3

External Ids:    HGNC: 62101   Entrez Gene: 37322   Ensembl: ENSG000000851177   OMIM: 6006235   UniProtKB: P277013   

Export aliases for CD82 gene to outside databases

Previous GC identifers: GC11P044544 GC11P044296


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD82 Gene:
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4
superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and
can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are
strongly correlated, and the loss of expression of these two proteins is associated with poor survival for
prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD82 Gene: 
CD82 (CD82 molecule) is a protein-coding gene. Diseases associated with CD82 include penile cancer, and facial paralysis, and among its related super-pathways are DNA damage response. GO annotations related to this gene include protein binding. An important paralog of this gene is CD151.

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701
Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Wiki entry for CD82 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD82 gene promoter:
         AP-1   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD82 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD82

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD82


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

CD82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD82 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P044586:  view genomic region     (about GC identifiers)

Start:
44,585,977 bp from pter      End:
44,641,913 bp from pter
Size:
55,937 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701 (See protein sequence)
Recommended Name: CD82 antigen  
Size: 267 amino acids; 29626 Da
Subunit: Interacts directly with IGSF8
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: D3DQN6 E9PC70 Q7Z2D4 Q7Z5N2
Alternative splicing: 2 isoforms:  P27701-1   P27701-2   

Explore the universe of human proteins at neXtProt for CD82: NX_P27701

Explore proteomics data for CD82 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P27701

  • CD82 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD82 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001020015.1  NP_002222.1  

    ENSEMBL proteins: 
     ENSP00000435682   ENSP00000227155   ENSP00000339686   ENSP00000431767   ENSP00000435661  
     ENSP00000433151   ENSP00000436403   ENSP00000433804   ENSP00000433788   ENSP00000433036  

    Human Recombinant Protein Products for CD82: 
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    Novus Biologicals CD82 Proteins
    Novus Biologicals CD82 Lysates
    Sino Biological Recombinant Protein for CD82
    Sino Biological Cell Lysate for CD82 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS7754374
    GO:0005887integral to plasma membrane TAS1842498
    GO:0016021integral to membrane ----

    CD82 for ontologies           About GeneDecksing



    CD82 Antibody Products: 
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    Assay Products for CD82: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P27701

    ProtoNet protein and cluster: P27701

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: CD82_HUMAN, P27701
    Similarity: Belongs to the tetraspanin (TM4SF) family


    CD82 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD82_HUMAN, P27701
    Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15205336
         
    CD82 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD82:
     Increased cilium length after   Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD82 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD82

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD82 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD82 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD82
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD82:
    hsa-miR-338-5p hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmidCD82 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for CD82
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                         Customized lentivirus expression plasmids for stable overexpression of CD82 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD82 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41
    2Lymphocyte Signaling
    Lymphocyte Signaling
    3Direct p53 effectors
    Direct p53 effectors
    4Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CD82
        Lymphocyte Signaling

    2 BioSystems Pathways for CD82
        Integrated Pancreatic Cancer Pathway
    Direct p53 effectors



    1         Kegg Pathway  (Kegg details for CD82):
        p53 signaling pathway


    CD82 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD82

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for CD82 (P277011, 3 ENSP000002271554) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000239329P280683, ENSP000003936464I2D: score=1 STRING: ENSP00000393646
    ENSG00000242092P280683, ENSP000003787234I2D: score=1 STRING: ENSP00000378723
    ENSG00000206308P019033, ENSP000003727464I2D: score=2 STRING: ENSP00000372746
    HLA-DRAP019033, ENSP000003787864I2D: score=2 STRING: ENSP00000378786
    ENSG00000226264P280683I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD82 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD82

    5 Novoseek inferred chemical compound relationships for CD82 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    at-61 83.6 1 9041184 (1)
    digitonin 29.5 1 12938224 (1)
    tyrosine 16 6 17215249 (4), 18395972 (1), 15454569 (1)
    cholesterol 0 4 12938224 (1), 15454569 (1)
    paraffin 0 1 15783050 (1)

    Search CenterWatch for drugs/clinical trials and news about CD82

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD82 gene (2 alternative transcripts): 
    NM_001024844.1  NM_002231.3  

    Unigene Cluster for CD82:

    CD82 molecule
    Hs.527778  [show with all ESTs]
    Unigene Representative Sequence: NM_002231
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526958 ENST00000227155(uc001myc.3 uc001myd.3) ENST00000342935
    ENST00000532544 ENST00000529277 ENST00000525210 ENST00000525898 ENST00000527737
    ENST00000524704 ENST00000525813 ENST00000529853 ENST00000530601 ENST00000530931
    ENST00000524750

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD82
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD82:
    hsa-miR-338-5p hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmidCD82 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD82
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD82
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    OriGene ORF clones in mouse, rat for CD82
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    GenScript: all cDNA clones in your preferred vector (see all 2): CD82 (NM_002231)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD82
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD82
    Sirion Biotech Customized lentivirus for stable overexpression of CD82 
                         Customized lentivirus expression plasmids for stable overexpression of CD82 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD82
    OriGene qSTAR qPCR primer pairs in human, mouse for CD82
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD82
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD82

    Additional mRNA sequence: 

    AK225410.1 AK225708.1 AK312677.1 AY303776.1 BC000726.2 BC001821.2 BT019761.1 BT019762.1 
    CR407650.1 CR542255.1 S48196.1 U20770.1 

    19 DOTS entries:

    DT.100793427  DT.313063  DT.97844941  DT.100793432  DT.120712758  DT.120712722  DT.92442010  DT.100793426 
    DT.120712724  DT.91742256  DT.100793430  DT.120712748  DT.120712751  DT.40261002  DT.95076548  DT.95076555 
    DT.120712720  DT.120753710  DT.95315953 

    24/268 AceView cDNA sequences (see all 268):

    CR615871 BI753805 AU077255 BU196310 BM353004 AI354379 BP366951 BE205860 
    AU119042 BU185132 BM473622 BU785446 BE871165 CR609000 BE293674 BU785750 
    BE349302 AW168332 CR606617 BG654786 BG759651 BM914425 CR593263 BE872332 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CD82 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                    -     -                 -                                             
    SP2:                    -     -                 -     -                                       
    SP3:                          -                 -                                             
    SP4:                                            -                                             
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CD82

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD82 expression in normal human tissues (normalized intensities)      CD82 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGGTGC
    CD82 Expression
    About this image


    CD82 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
             Septum   
     
     Thymus (Hematopoietic System)
             Thymus
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Cartilage (Muscoskeletal System)
             fetal cartilage   
     
     Tonsil (Hematopoietic System)

    See CD82 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD82

    SOURCE GeneReport for Unigene cluster: Hs.527778

    UniProtKB/Swiss-Prot: CD82_HUMAN, P27701
    Tissue specificity: Lymphoid specific

        SABiosciences Expression via Pathway-Focused PCR Array including CD82: 
              Tumor Metastasis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD82
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CD82 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd821 , 5 CD82 antigen1, 5 79.57(n)1
    76.69(a)1
      2 (51.62 cM)5
    125211  NM_001136055.11  NP_001129527.11 
     934191115 
    chicken
    (Gallus gallus)
    Aves CD821 CD82 molecule 64.36(n)
    61.54(a)
      423172  NM_001008470.1  NP_001008470.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    65(a)
    41(a)
    1 ↔ many
    1 ↔ many
    1(46098567-46152689)
    GL343557.1(328922-329948)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240832 Xenopus laevis transcribed sequence with weak similarity more 76.08(n)    BJ061882.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054586.12   -- 71.75(n)    BC054586.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp66E1 Tetraspanin 66E 50.35(n)
    32.34(a)
      39017  NM_168298.1  NP_729423.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-81 Protein TSP-8 41.73(n)
    30(a)
      181567  NM_078044.4  NP_510445.1 


    ENSEMBL Gene Tree for CD82 (if available)
    TreeFam Gene Tree for CD82 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD82 gene
    CD1512  TSPAN12  TSPAN62  CD372  TSPAN32  TSPAN92  CD632  TSPAN192  
    CD532  TSPAN182  TSPAN72  TSPAN112  TSPAN42  ENSG000002503492  
    18/22 SIMAP similar genes for CD82 using alignment to 10 protein entries:     CD82_HUMAN (see all proteins) (see all similar genes):
    TSPAN18    CD37    BTCC-1    CD81    CD9    TSPAN19
    TSPAN4    CD53    TSPAN2    CD151    TSPAN11    TSPAN5
    TSPAN1    TSPAN9    TSPAN17    TM4SF2    TSPAN7    TM4SF9

    CD82 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1236 SNPs in CD82 are shown (see all 1236)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411712661,2
    C--44326750(+) AAAAA-/GAATTT 2 -- int10--------
    rs122811841,2
    C,F--44329262(+) CTCTTG/CTTGTC 2 -- int14Minor allele frequency- C:0.16NA CSA WA 242
    rs122241741,2
    C,H--44513646(+) tctgcC/Tataca 2 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1168926241,2
    C,F--44513667(+) CACCCC/GCAGCT 2 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1436699671,2
    --44513893(+) ACTGCC/TGGGTT 2 -- us2k10--------
    rs794033001,2
    F--44513943(+) GAATGC/TTATGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1812916241,2
    --44513991(+) ATGTAC/TGGCAT 2 -- us2k10--------
    rs1850225611,2
    --44514064(+) AGATCA/GGTATG 2 -- us2k10--------
    rs1465714621,2
    --44514108(+) TTAAGA/GGCTCA 2 -- us2k10--------
    rs124195391,2
    C,H--44514171(+) GCTACT/CTAGGT 2 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for CD82 (44585977 - 44641913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD82:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522766CNV Loss19592680
    nsv897308CNV Loss21882294
    nsv525321CNV Gain19592680
    nsv897309CNV Gain21882294
    nsv897306CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CD82
    DNA2.0 Custom Variant and Variant Library Synthesis for CD82

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600623   
    OMIM disorders: 176807  
    20/50 diseases for CD82 (see all 50):    About MalaCards
    penile cancer    facial paralysis    gallbladder adenocarcinoma    cervical cancer
    renal oncocytoma    prostatitis    bladder carcinoma    newcastle disease
    prostate cancer    oral cancer    paralysis    human t-cell leukemia virus type 1
    cervicitis    cervical squamous cell carcinoma    pancreatic cancer    laryngitis
    papillary carcinoma    laryngeal carcinoma    squamous cell carcinoma    laryngeal squamous cell carcinoma

    3 diseases from the University of Copenhagen DISEASES database for CD82:
    Facial paralysis     Carcinoma     Prostate cancer

    CD82 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/43 Novoseek inferred disease relationships for CD82 gene (see all 43)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 74.8 303 18028322 (6), 12753720 (6), 8813131 (6), 17283532 (6) (see all 99)
    prostate cancer 59 80 10440748 (7), 8813131 (5), 9254900 (5), 11572762 (4) (see all 36)
    cancer 52.8 100 9671393 (4), 11331321 (3), 9699525 (3), 10440748 (2) (see all 52)
    pancreatic cancer 51.3 39 15944768 (5), 18286698 (5), 19489224 (4), 8895737 (4) (see all 12)
    allelic loss 48.5 12 8813131 (5), 11895916 (1), 9126478 (1), 9254900 (1) (see all 5)
    tumors 47.7 161 12684410 (5), 10568187 (5), 10873402 (5), 9736732 (5) (see all 62)
    primary tumor 44.6 23 11895916 (2), 10582691 (2), 17308076 (2), 15592684 (1) (see all 11)
    bladder cancer 40.4 27 17982617 (4), 10767717 (3), 10840154 (3), 9815782 (3) (see all 8)
    carcinoma 35.7 35 15259074 (6), 18575327 (3), 12747469 (2), 19024519 (2) (see all 16)
    metastatic cancer 35.7 4 16271511 (1), 11715465 (1)

    Genetic Association Database (GAD): CD82
    Human Genome Epidemiology (HuGE) Navigator: CD82 (1 document)

    Export disorders for CD82 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD82 gene, integrated from 9 sources (see all 283) (see top 10):
    (articles sorted by number of sources associating them with CD82)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human KAI1 metastasis-suppressor gene. (PubMed id 9126478)1, 2, 9 Dong J.T.... Isaacs J.T. (1997)
    2. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. (PubMed id 7754374)1, 2, 9 Dong J.T. and Barrett J.C. (1995)
    3. C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. (PubMed id 1401919)1, 2, 9 Imai T.... Yoshie O. (1992)
    4. Genome wide association study for plasma levels of nat ural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA pr oject. (PubMed id 22443383)1, 4 Oudot-Mellakh T....Morange P.E. (2012)
    5. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PubMed id 12750295)1, 2 Zhang X.A.... Liu L. (2003)
    6. A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23. (PubMed id 1842498)1, 2 Gaugitsch H.W.... Baumruker T. (1991)
    7. High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis. (PubMed id 11895916)1, 9 Uzawa K....Tanzawa H. (2002)
    8. Loss of KAI1 expression in the progression of colorectal cancer. (PubMed id 10582691)1, 9 Lombardi D.P....Barrett J.C. (1999)
    9. CD82, and CD63 in thyroid cancer. (PubMed id 15375577)1, 9 Chen Z....Hoang-Vu C. (2004)
    10. [Role of tumor metastasis suppressor gene KAI1 in development of colorectal cancer] (PubMed id 12753720)1, 9 Yang J....Liu L.M. (2003)
    11. KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer. (PubMed id 18712725)1, 9 Christgen M....Lehmann U. (2008)
    12. Expression of the metastasis suppressor KAI1 in decidual cells at the human maternal-fetal interface: Regulation and functional implications. (PubMed id 17200188)1, 9 Gellersen B....Bamberger A.M. (2007)
    13. KAI1 metastasis suppressor protein is down-regulated during the progression of human endometrial cancer. (PubMed id 12684410)1, 9 Liu F.S....Chiou L.C. (2003)
    14. An alternatively spliced KAI1 mRNA is expressed at low levels in human bladder cancers and bladder cancer cell lines and is not associated with invasive behaviour. (PubMed id 17982617)1, 9 Jackson P....Grimm M.O. (2007)
    15. Transcriptional and translational modulation of KAI1 expression in ductal carcinoma of the breast and the prognostic significance. (PubMed id 19148553)1, 9 Malik F.A....Jiang W.G. (2009)
    16. [Expression of nm23 and KAI1 and their clinical significance in gallbladder adenocarcinoma] (PubMed id 19024519)1, 9 Jiang W.X....Fang J.P. (2008)
    17. [Expression of KAI1 gene in human laryngeal carcinoma and its clinical significance] (PubMed id 15996322)1, 9 Bai W.L....Gao H. (2005)
    18. Decreased expression of KAI1 metastasis suppressor gene is a recurrence predictor in primary pTa and pT1 urothelial bladder carcinoma. (PubMed id 14706010)1, 9 Su J.S....Kawamura J. (2004)
    19. Relationship between expression of KAI1 metastasis suppressor gene, mRNA levels and p53 in human bladder and prostate cancer cell lines. (PubMed id 12474542)1, 9 Jackson P....Russell P.J. (2002)
    20. Effect of expressional alteration of KAI1 on breast c ancer cell growth, adhesion, migration and invasion. (PubMed id 19656997)1, 9 Malik F.A....Jiang W.G. (2009)
    21. [Role of KAI1 gene expression and loss of heterozygos ity of KAI1 in metastatic potential and prognosis of pancreatic cancer] (PubMed id 19489224)1, 9 Fan L.X....Zhang Y. (2009)
    22. KAI1 gene suppresses invasion and metastasis of hepatocellular carcinoma MHCC97-H cells in vitro and in animal models. (PubMed id 18028322)1, 9 Yang J.M....Ye Z.Y. (2008)
    23. KAI1 gene expression in colonic carcinoma and its clinical significances. (PubMed id 15259074)1, 9 Wu D.H....Ding Y.Q. (2004)
    24. Expression of KAI1/CD82 in distant metastases from es trogen receptor-negative breast cancer. (PubMed id 19549254)1, 9 Christgen M....Lehmann U. (2009)
    25. Tumor suppressor KAI1 affects integrin alphavbeta3-mediated ovarian cancer cell adhesion, motility, and proliferation. (PubMed id 19371633)1, 9 Ruseva Z....Reuning U. (2009)
    26. Phorbol ester enhances KAI1 transcription by recruiting Tip60/Pontin complexes. (PubMed id 19048121)1, 9 Rowe A....Jackson P. (2008)
    27. [Relationship between the expressions of KaI1, nm23, ETS-1, VEGF and microvascular density and clinical significance in nasopharyngeal carcinoma] (PubMed id 17283532)1, 9 He S.Q. and Zhang W.Y. (2006)
    28. KAI1 expression in thyroid neoplasms: its linkage with clinicopathologic features in papillary carcinoma. (PubMed id 12747469)1, 9 Ito Y....Miyauchi A. (2003)
    29. Expression and clinical significance of p53, JunB and KAI1/CD82 in human hepatocellular carcinoma. (PubMed id 19666408)1, 9 Guo C....Yang X. (2009)
    30. Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse. (PubMed id 17215249)1, 9 Todeschini A.R....Hakomori S.I. (2007)
    31. Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion. (PubMed id 15557282)1, 9 He B....Zhang X.A. (2005)
    32. Expression of tetraspanin adaptor proteins below defined threshold values is associated with in vitro invasiveness of mammary carcinoma cells. (PubMed id 12579280)1, 9 Sauer G....Deissler H. (2003)
    33. The inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag protein. (PubMed id 17166843)1, 9 Mazurov D....Derse D. (2007)
    34. KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer. (PubMed id 15205336)1, 9 Lee J.H....Kim K.K. (2004)
    35. Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR. (PubMed id 14576349)1, 9 Odintsova E....Berditchevski F. (2003)
    36. Role of tumor metastasis suppressor gene KAI1 in digestive tract carcinomas and cancer cells. (PubMed id 12955496)1, 9 Wu Q....Su W.J. (2003)
    37. Role of TI-VAMP and CD82 in EGFR cell-surface dynamic s and signaling. (PubMed id 20144992)1, 9 Danglot L....Galli T. (2010)
    38. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. (PubMed id 15592684)1, 9 Stark A.M....Held-Feindt J. (2005)
    39. Regulation of urokinase receptor proteolytic function by the tetraspanin CD82. (PubMed id 15677461)1, 9 Bass R....Ellis V. (2005)
    40. Effects of KAI1 gene on growth and invasion of human hepatocellular carcinoma MHCC97-H cells. (PubMed id 15237426)1, 9 Si S.H....Zhou P. (2004)
    41. The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation. (PubMed id 18037895)1, 9 Tsai Y.C....Weissman A.M. (2007)
    42. CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82. (PubMed id 9804823)1, 9 Horvath G....Rubinstein E. (1998)
    43. Expression of nm23, KAI1 and spiral computed tomograp hy findings in primary gallbladder carcinoma. (PubMed id 19951590)1, 9 Jiang W.X....Wang P.J. (2009)
    44. Tetraspanin-induced death of myeloma cell lines is au tophagic and involves increased UPR signalling. (PubMed id 19755988)1, 9 Zismanov V....Drucker L. (2009)
    45. Down-regulation of the metastasis suppressor protein KAI1/CD82 correlates with occurrence of metastasis, prognosis and presence of HPV DNA in human penile squamous cell carcinoma. (PubMed id 18305955)1, 9 Protzel C....Giebel J. (2008)
    46. Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor. (PubMed id 18981120)1, 9 Arduise C....Le Naour F. (2008)
    47. KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2. (PubMed id 18622748)1, 9 Mu Z....Guo X. (2008)
    48. [Effect of metastasis suppressor gene KAI1 on adhesion of hepatocellular carcinoma cell line MHCC97-H] (PubMed id 17672940)1, 9 Yu Y....Liu W. (2007)
    49. Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1. (PubMed id 16735575)1, 9 Nydegger S....Thali M. (2006)
    50. A novel link between SUMO modification and cancer metastasis. (PubMed id 16861889)1, 9 Baek S.H. (2006)
    51. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. (PubMed id 15829968)1, 9 Kim J.H....Baek S.H. (2005)
    52. Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation. (PubMed id 15454569)1, 9 Delaguillaumie A....Conjeaud H. (2004)
    53. Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathway. (PubMed id 12642901)1, 9 Jee B....Lee H. (2003)
    54. Distinctive signaling pathways through CD82 and beta1 integrins in human T cells. (PubMed id 11981820)1, 9 Iwata S....Morimoto C. (2002)
    55. Human endometrial stromal cell-trophoblast interaction s: mutual stimulation of chemotactic migration and promigratory roles of cell su rface molecules CD82 and CEACAM1. (PubMed id 23349235)1 Gellersen B....Bamberger A.M. (2013)
    56. Genome-wide association and longitudinal analyses reve al genetic loci linking pubertal height growth, pubertal timing and childhood ad iposity. (PubMed id 23449627)1 Cousminer D.L....Widen E. (2013)
    57. CD34^+/CD38^- acute myelogenous leukemia cells aberran tly express CD82 which regulates adhesion and survival of leukemia stem cells. (PubMed id 23055153)1 Nishioka C....Yokoyama A. (2013)
    58. N-Glycosylation pattern of recombinant human CD82 (KAI 1), a tumor-associated membrane protein. (PubMed id 22123080)1 Wang H....Yang P. (2012)
    59. Tetraspanin CD82 inhibits protrusion and retraction in cell movement by attenuating the plasma membrane-dependent actin organization. (PubMed id 23251627)1 Liu W.M....Zhang X.A. (2012)
    60. Expression and clinical significance of CD82/KAI1 and E-cadherin in non-small cell lung cancer. (PubMed id 23102249)1 Shiwu W.U....Yisheng T. (2012)
    61. [Relationship among the expression of lymphatic vessel density, microvessel density, carcinoembryonic antigenic mRNA, KAI1, and Kiss-1 , and prognosis in patients with non-small cell lung cancer]. (PubMed id 22681921)1 Wang G....Cheng Z. (2012)
    62. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    63. CD82 expression alters with human endometrial cycles a nd affects the uterine endometrial receptivity in vitro. (PubMed id 22393164)1 Wei X....Yan Q. (2012)
    64. Utility of immunohistochemical analysis of KAI1, epith elial-specific antigen, and epithelial-related antigen for distinction of chromo phobe renal cell carcinoma, an eosinophilic variant from renal oncocytoma. (PubMed id 22718295)1 Ohe C....Uemura Y. (2012)
    65. KAI1 suppresses HIF-1a and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer. (PubMed id 22390300)1 Park J.J....Lee M. (2012)
    66. An inverse relationship between KAI1 expression, invas ive ability, and MMP-2 expression and activity in bladder cancer cell lines. (PubMed id 20864363)1 You J....Jackson P. (2012)
    67. CD82 inhibits canonical Wnt signalling by controlling the cellular distribution of b-catenin in carcinoma cells. (PubMed id 23076981)1 Chigita S....Shirasuna K. (2012)
    68. Expression of CD82 in human trophoblast and its role i n trophoblast invasion. (PubMed id 22679510)1 Zhang Q....Tan Y. (2012)
    69. CsA improves the trophoblasts invasiveness through str engthening the cross-talk of trophoblasts and decidual stromal cells mediated by CXCL12 and CD82 in early pregnancy. (PubMed id 22670173)1 Meng Y.H....Li D.J. (2012)
    70. Down-regulation of TM4SF is associated with the metas tatic potential of gastric carcinoma TM4SF members in gastric carcinoma. (PubMed id 21521534)1 Chen Z....Hoang-Vu C. (2011)
    71. [Expression of CD82/KAI1 and HIF-1a in non-small cell lung cancer and their relationship to vasculogenic mimicry]. (PubMed id 22152691)1 Wu S....Tao Y. (2011)
    72. Expressional alterations and transcript isoforms of me tastasis suppressor genes (KAI1 and KiSS1) in breast cancer patients. (PubMed id 22320993)1 Mooez S....Khan A. (2011)
    73. KAI1 gene is engaged in NDRG1 gene-mediated metastasi s suppression through the ATF3-NFkappaB complex in human prostate cancer. (PubMed id 21454613)1 Liu W....Watabe K. (2011)
    74. KAI1 inhibits HGF-induced invasion of pancreatic canc er by sphingosine kinase activity. (PubMed id 21459729)1 Liu X....Wang L.S. (2011)
    75. Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and I^1 integrin activation. (PubMed id 21691075)1 Lee H.A....Lee H. (2011)
    76. Lack of germ line changes in KISS1 and KAI1 genes in s poradic head and neck cancer patients of Pakistani origin. (PubMed id 22320990)1 Nazir M....Kayani M.A. (2011)
    77. HIF-2 directly activates CD82 gene expression in endo thelial cells. (PubMed id 21382346)1 Nagao K. and Oka K. (2011)
    78. The tetraspanin CD82 is specifically recruited to fun gal and bacterial phagosomes prior to acidification. (PubMed id 21149584)1 Artavanis-Tsakonas K....Vyas J.M. (2011)
    79. Overexpression of KAI1 induces autophagy and increase s MiaPaCa-2 cell survival through the phosphorylation of extracellular signal-r egulated kinases. (PubMed id 21168384)1 Wu C.Y....Wang H. (2011)
    80. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    81. [Correlation of CD82 and hTERT expressions and HPV inf ection with penile cancer]. (PubMed id 21961244)1 Zhai J.P....Xu K.X. (2011)
    82. CD82 gene suppression in endometrial stromal cells le ads to increase of the cell invasiveness in the endometriotic milieu. (PubMed id 21685244)1 Li M.Q....Li D.J. (2011)
    83. Expression of thymidylate synthase and dihydropyrimid ine dehydrogenase in primary oral squamous cell carcinoma and corresponding met astases in cervical lymph nodes: association with the metastasis suppressor CD8 2. (PubMed id 21965773)1 Kawasaki G....Umeda M. (2011)
    84. Dissecting the diverse functions of the metastasis su ppressor CD82/KAI1. (PubMed id 21875585)1 Tsai Y.C. and Weissman A.M. (2011)
    85. The DSCs-expressed CD82 controls the invasiveness of trophoblast cells via integrinbeta1/MAPK/MAPK3/1 signaling pathway in human fir st-trimester pregnancy. (PubMed id 20075392)1 Li M.Q....Li D.J. (2010)
    86. A role for KAI1 in promotion of cell proliferation an d mammary gland hyperplasia by the gp78 ubiquitin ligase. (PubMed id 20089858)1 Joshi B....Nabi I.R. (2010)
    87. Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/beta-catenin sig nal via ISGylation of beta-catenin. (PubMed id 20581239)1 Lee J.H....Kim K.K. (2010)
    88. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    89. A role for CD81 on the late steps of HIV-1 replication in a chronically infected T cell line. (PubMed id 19284574)1 Grigorov B....Muriaux D. (2009)
    90. Control of cell motility by interaction of gangliosid es, tetraspanins, and epidermal growth factor receptor in A431 versus KB epider moid tumor cells. (PubMed id 19559406)1 Park S.Y....Hakomori S.I. (2009)
    91. Identifying CD82 (KAI1) as a marker for human chromop hobe renal cell carcinoma. (PubMed id 20002769)1 Yusenko M.V. and Kovacs G. (2009)
    92. Human immunodeficiency virus type-1 gag and host vesic ular trafficking pathways. (PubMed id 20012524)1 Chu H....Spearman P. (2009)
    93. KAI1/CD82 decreases Rac1 expression and cell proliferation through PI3K/Akt/mTOR pathway in H1299 lung carcinoma cells. (PubMed id 19107873)1 Choi U.J....Lee K.H. (2009)
    94. Decreased expression of KAI1/CD82 metastasis suppressor gene is associated with loss of heterozygosity in melanoma cell lines. (PubMed id 19082457)1 Kim Y.I....Lee M.H. (2009)
    95. Human Discs Large is a new negative regulator of human immunodeficiency virus-1 infectivity. (PubMed id 18946087)1 Perugi F....Pique C. (2009)
    96. CD82 endocytosis and cholesterol-dependent reorganiza tion of tetraspanin webs and lipid rafts. (PubMed id 19497983)1 Xu C....Zhang X.A. (2009)
    97. Transmembrane interactions are needed for KAI1/CD82-mediated suppression of cancer invasion and metastasis. (PubMed id 19116362)1 Bari R....Zhang X.A. (2009)
    98. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    99. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)2 Wollscheid B.... Watts J.D. (2009)
    100. Gene expression profiling of chromophobe renal cell c arcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individ ual tumours. (PubMed id 19680475)1 Yusenko M.V....Kovacs G. (2009)
    101. Resolution of de novo HIV production and trafficking i n immature dendritic cells. (PubMed id 18059278)1 Turville S.G....Robbiani M. (2008)
    102. HIV-1 replication in dendritic cells occurs through a tetraspanin-containing compartment enriched in AP-3. (PubMed id 18034776)1 Garcia E....Piguet V. (2008)
    103. Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins. (PubMed id 17989173)1 Sato K....Koyanagi Y. (2008)
    104. Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. (PubMed id 18272501)1 Todeschini A.R....Hakomori S.I. (2008)
    105. Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas. (PubMed id 18415123)1 Briese J....Bamberger A.M. (2008)
    106. HIV-1 buds predominantly at the plasma membrane of pri mary human macrophages. (PubMed id 17381240)1 Welsch S....Krausslich H.G. (2007)
    107. Expression of KAI1/CD82 and MRP-1/CD9 in transitional cell carcinoma of bladder. (PubMed id 17393117)1 Ai X....Shi T. (2007)
    108. [In situ hybridization study on the expression of Kis s-1 and KAI-1 metastasis suppressor genes in gastric cancer] (PubMed id 17520389)1 Yao H.L....Liu G.W. (2007)
    109. Regulation of c-Met signaling by the tetraspanin KAI-1/CD82 affects cancer cell migration. (PubMed id 17621632)1 Takahashi M....Shirasuna K. (2007)
    110. Effect of KAI1/CD82 on the beta1 integrin maturation in highly migratory carcinoma cells. (PubMed id 17560548)1 Jee B.K....Jo Y.H. (2007)
    111. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    112. KAI1/CD82 suppresses tumor invasion by MMP9 inactivation via TIMP1 up-regulation in the H1299 human lung carcinoma cell line. (PubMed id 16488391)1 Jee B.K....Lim Y. (2006)
    113. HTLV-1 Gag protein associates with CD82 tetraspanin microdomains at the plasma membrane. (PubMed id 16325219)1 Mazurov D....Derse D. (2006)
    114. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    115. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    116. [Expression and clinical value of KAI1/CD82 in carcin oma of larynx]. (PubMed id 16494006)1 Shu Y....Tan Y. (2005)
    117. The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity. (PubMed id 15492270)1 Zhou B....Zhang X.A. (2004)
    118. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    119. Requirement of the p130CAS-Crk coupling for metastasis suppressor KAI1/CD82-mediated inhibition of cell migration. (PubMed id 12738793)1 Zhang X.A....Liu L. (2003)
    120. Infectious HIV-1 assembles in late endosomes in primar y macrophages. (PubMed id 12885763)1 Pelchen-Matthews A....Marsh M. (2003)
    121. Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes. (PubMed id 11839793)1 Delaguillaumie A....Conjeaud H. (2002)
    122. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    123. Quality control of transmembrane domain assembly in the tetraspanin CD82. (PubMed id 11350933)1 Cannon K.S. and Cresswell P. (2001)
    124. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. (PubMed id 11278880)1 Charrin S.... Rubinstein E. (2001)
    125. The endocytic pathway: a mosaic of domains. (PubMed id 11584299)1 Gruenberg J. (2001)
    126. Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells. (PubMed id 11162423)1 Ono M....Hakomori S. (2000)
    127. Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. (PubMed id 10985391)1 Odintsova E....Berditchevski F. (2000)
    128. Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity. (PubMed id 10749879)1 Nakamura K....Mekada E. (2000)
    129. CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. (PubMed id 10741407)1 Lozahic S....Rubinstein E. (2000)
    130. Overexpression of CD82 on human T cells enhances LFA-1 / ICAM-1-mediated cell-cell adhesion: functional association between CD82 and LFA-1 in T cell activation. (PubMed id 10602019)1 Shibagaki N....Hamada H. (1999)
    131. Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. (PubMed id 10229664)1 Serru V....Rubinstein E. (1999)
    132. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules. (PubMed id 9759843)1 Hammond C....Cresswell P. (1998)
    133. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. (PubMed id 9685355)1 Escola J.M....Geuze H.J. (1998)
    134. Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29). (PubMed id 8757325)1 Mannion B.A....Hemler M.E. (1996)
    135. Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. (PubMed id 8816400)1 Szollosi J....Damjanovich S. (1996)
    136. Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. (PubMed id 7636191)1 Imai T....Yoshie O. (1995)
    137. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
    138. Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. (PubMed id 1596907)1 Ichikawa T....Isaacs J.T. (1992)
    139. Genetic factors and suppression of metastatic ability of prostatic cancer. (PubMed id 2065333)1 Ichikawa T....Isaacs J.T. (1991)
    140. Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. (PubMed id 16862154)9 Bandyopadhyay S....Watabe K. (2006)
    141. Down-regulation of KAI1 messenger RNA expression is not associated with loss of heterozygosity of the KAI1 gene region in lung adenocarcinoma. (PubMed id 10551326)9 Tagawa K....Inai K. (1999)
    142. KAI1 protein is down-regulated during the progression of human breast cancer. (PubMed id 10999724)9 Yang X....Lippman M. (2000)
    143. CD82 (KAI1), a member of the tetraspan family, is expressed on early haemopoietic progenitor cells and up-regulated in distinct human leukaemias. (PubMed id 10583248)9 Burchert A....Thiel E. (1999)
    144. Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss. (PubMed id 8813131)9 Dong J.T....Isaacs J.T. (1996)
    145. KAI1, a new metastasis suppressor gene, is reduced in metastatic hepatocellular carcinoma. (PubMed id 9828210)9 Guo X.Z....Buchler M.W. (1998)
    146. Reduced KAI1 expression in pancreatic cancer is associated with lymph node and distant metastases. (PubMed id 9699525)9 Friess H....Buchler M.W. (1998)
    147. Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression. (PubMed id 8039242)9 Nagira M....Yoshie O. (1994)
    148. Reduced expression of the metastasis suppressor gene KAI1 in advanced colon cancer and its metastases. (PubMed id 10568187)9 Maurer C.A....Buchler M.W. (1999)
    149. KAI1 is unchanged in metastatic and nonmetastatic esophageal and gastric cancers. (PubMed id 9485031)9 Guo X.Z....Buchler M.W. (1998)
    150. Downregulation of KAI1 mRNA in localised prostate cancer and its bony metastases does not correlate with p53 overexpression. (PubMed id 12806379)9 Jackson P....Russell P.J. (2003)
    151. Identification of regulatory regions within the KAI1 promoter: a role for binding of AP1, AP2 and p53. (PubMed id 12527206)9 Marreiros A....Jackson P. (2003)
    152. Downregulation of KAI1 metastasis suppressor protein is associated with a dismal prognosis in epithelial ovarian cancer. (PubMed id 11606078)9 Schindl M....Oberhuber G. (2001)
    153. KAI1 metastasis suppressor gene is frequently down-regulated in cervical carcinoma. (PubMed id 11696423)9 Liu F.S....Lu C.H. (2001)
    154. Frequent down-regulation and lack of mutation of the KAI1 metastasis suppressor gene in epithelial ovarian carcinoma. (PubMed id 10873402)9 Liu F.S....Hung M.J. (2000)
    155. Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues. (PubMed id 10362791)9 Geradts J....Lombardi D.P. (1999)
    156. CD82, tetra-span-transmembrane protein, is a regulated transducing molecule on U937 monocytic cell line. (PubMed id 7790779)9 Lebel-Binay S....Conjeaud H. (1995)
    157. Differential expression of KAI1 metastasis suppressor protein in renal cell tumor histological subtypes. (PubMed id 19303095)9 Kauffman E.C....Tu J.J. (2009)
    158. Prognostic values of KAI1 and survivin expression in an infiltrating ductal carcinoma of the breast. (PubMed id 16028840)9 Son B.H....Lee J.H. (2005)
    159. KAI1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastases. (PubMed id 8895737)9 Guo X....Buchler M.W. (1996)
    160. Molecular cloning and expression analysis of CD82 in pig. (PubMed id 18855249)9 Cho K.W....Kim Y.B. (2008)
    161. KAI1 is a potential target for anti-metastasis in pancreatic cancer cells. (PubMed id 18286698)9 Xu J.H....Liu M.P. (2008)
    162. [Expression of KAI1, MRP-1, and FAK proteins in lung cancer detected by high-density tissue microarray] (PubMed id 16159431)9 Wang X.Y....Wang A.X. (2005)
    163. Expression of a splice variant of KAI1, a tumor metastasis suppressor gene, influences tumor invasion and progression. (PubMed id 14612520)9 Lee J.H....Kim K.K. (2003)
    164. Overexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells. (PubMed id 11431371)9 Yang X....Lippman M.E. (2001)
    165. Expression of the prostate cancer metastasis suppressor gene KAI1 in primary prostate cancers: a biphasic relationship with tumour grade. (PubMed id 10440748)9 Bouras T. and Frauman A.G. (1999)
    166. KAI1, a putative marker for metastatic potential in human breast cancer. (PubMed id 9570365)9 Yang X....Wei L.L. (1997)
    167. Loss of KAI1 expression in gastric cancer. (PubMed id 15783050)9 Tsutsumi S....Kuwano H. (2005)
    168. KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells. (PubMed id 15580298)9 Marreiros A....Jackson P. (2005)
    169. Differential expression of metastasis-associated genes in papilla of vater and pancreatic cancer correlates with disease stage. (PubMed id 11331321)9 Friess H....Buchler M.W. (2001)
    170. Relationship between expression of the KAI1 metastasis suppressor and other markers of advanced bladder cancer. (PubMed id 10767717)9 Ow K....Russell P.J. (2000)
    171. Frequent downregulation of the KAI1(CD82) metastasis suppressor protein in human cancer cell lines. (PubMed id 9671393)9 White A....Barrett J.C. (1998)
    172. Novel staging protocol for non-small-cell lung cancers according to MRP-1/CD9 and KAI1/CD82 gene expression. (PubMed id 9552043)9 Adachi M....Miyake M. (1998)
    173. Loss of KAI1 messenger RNA expression in both high-grade and invasive human bladder cancers. (PubMed id 9815782)9 Yu Y....Russell P.J. (1997)
    174. Expression of KAI1 and tenascin, and microvessel density are closely correlated with liver metastasis of gastrointestinal adenocarcinoma. (PubMed id 16698949)9 Zheng H....Takano Y. (2007)
    175. [Inhibitory effect of KAI1 gene on breast cancer cell growth in vitro] (PubMed id 18210875)9 Lu D....Yang Y. (2007)
    176. Interaction of Duffy antigen receptor for chemokines and KAI1: a critical step in metastasis suppression. (PubMed id 17308076)9 Iiizumi M....Watabe K. (2007)
    177. [Adenovirus-mediated overexpression of KAI1 suppresses sphingosine kinase activation and metastasis of pancreatic carcinoma cells] (PubMed id 17166452)9 Guo X.Z....Tian H. (2006)
    178. CD82 metastasis suppressor gene: a potential target for new therapeutics? (PubMed id 16271511)9 Tonoli H. and Barrett J.C. (2005)
    179. Effects of KAI1/CD82 on biological behavior of human colorectal carcinoma cell line. (PubMed id 12800230)9 Liu L....Ding Y.Q. (2003)
    180. Defining regulatory elements in the human KAI1 (CD 82) metastasis suppressor gene. (PubMed id 14601021)9 Gao A.C....Isaacs J.T. (2003)
    181. Expression of the KAI1 metastasis suppressor gene in non-metastatic versus metastatic human colorectal cancer. (PubMed id 12530084)9 Yang J.L....Crowe P.J. (2002)
    182. Epigenetic regulation of the KAI1 metastasis suppressor gene in human prostate cancer cell lines. (PubMed id 11572762)9 Sekita N....Ito H. (2001)
    183. Interaction of CD82 tetraspanin proteins with HTLV-1 envelope glycoproteins inhibits cell-to-cell fusion and virus transmission. (PubMed id 11040136)9 Pique C....Dokhelar M.C. (2000)
    184. Mutation and expression of the metastasis suppressor gene KAI1 in esophageal squamous cell carcinoma. (PubMed id 10964324)9 Miyazaki T....Kuwano H. (2000)
    185. The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53. (PubMed id 9736732)9 Mashimo T....Watabe K. (1998)
    186. Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene. (PubMed id 9525743)9 Takaoka A....Imai K. (1998)
    187. Reduced invasive and metastatic potentials of KAI1-transfected melanoma cells. (PubMed id 9617345)9 Takaoka A....Imai K. (1998)
    188. Functional analysis of four tetraspans, CD9, CD53, CD81, and CD82, suggests a common role in costimulation, cell adhesion, and migration: only CD9 upregulates HB-EGF activity. (PubMed id 9514697)9 Lagaudriere-Gesbert C....Rubinstein E. (1997)
    189. [Expression of metastasis suppressor gene KAI1/CD82 in cervical squamous cell carcinoma and its clinical significance.] (PubMed id 15642213)9 Xiong Y....Wei M. (2005)
    190. KAI1 inhibits anchorage-dependent and -independent pancreatic cancer cell growth. (PubMed id 15944768)9 Guo X.Z....Friess H. (2005)
    191. KAI1 tetraspanin and metastasis suppressor. (PubMed id 15618009)9 Jackson P....Russell P.J. (2005)
    192. The impact of expression of the metastasis suppressor protein KAI1 on prognosis in invasive squamous cell cervical cancer. (PubMed id 11205303)9 Schindl M....Oberhuber G. (2000)
    193. Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines. (PubMed id 10936677)9 Jackson P....Russell P.J. (2000)
    194. Functional analysis of CD82 in the early phase of T cell activation: roles in cell adhesion and signal transduction. (PubMed id 9565351)9 Shibagaki N....Hamada H. (1998)
    195. KAI1 gene expression in hepatocellular carcinoma and its relationship with intrahepatic metastases. (PubMed id 9894767)9 Sun H.C....Li X.M. (1998)
    196. Location of KAI1 on the short arm of human chromosome 11 and frequency of allelic loss in advanced human prostate cancer. (PubMed id 9254900)9 Kawana Y....Ichikawa T. (1997)
    197. [Expression of metastasis suppressor gene KAI1 in cervical carcinoma and infections of HPV16 E6, E7 and HPV18 E6/E7] (PubMed id 18575327)9 Ouyang Y.W....Zhang H.Y. (2008)
    198. Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and ganglioside. (PubMed id 17942932)9 Wang X.Q....Paller A.S. (2007)
    199. Protein networking in bladder cancer: immunoreactivity for FGFR3, EGFR, ERBB2, KAI1, PTEN, and RAS in normal and malignant urothelium. (PubMed id 17290345)9 Rotterud R....Nesland J.M. (2007)
    200. Reduced protein expression of metastasis-related genes (nm23, KISS1, KAI1 and p53) in lymph node and liver metastases of gastric cancer. (PubMed id 17504447)9 Guan-Zhen Y....Jie-Jun W. (2007)
    201. Evaluation of specificity and effects of monoclonal antibodies submitted to the Eighth Human Leucocyte Differentiation Antigen Workshop on rotavirus-cell attachment and entry. (PubMed id 16169540)9 Halasz P....Coulson B.S. (2005)
    202. Evaluation of tumor malignancy in esophageal squamous cell carcinoma using different characteristic factors. (PubMed id 16309192)9 Miyazaki T....Kuwano H. (2005)
    203. [Effect of tumor suppressor gene KAI1 on the biological behaviors of human colorectal carcinoma] (PubMed id 12810384)9 Liu L....Ding Y.Q. (2003)
    204. [Study on the expression of the metastasis suppressor gene KAI1 in laryngeal squamous cell carcinoma] (PubMed id 15040100)9 Wu Z.L....Guo X. (2003)
    205. Frequent low level expression in Ewing sarcoma family tumors and widespread absence of the metastasis suppressor KAI1/CD82 in neuroblastoma. (PubMed id 12149507)9 Aryee D.N....Kovar H. (2002)
    206. Inverse correlation between KAI1 mRNA levels and invasive behaviour in bladder cancer cell lines. (PubMed id 10840154)9 Jackson P....Russell P.J. (2000)
    207. Activation of the tumor metastasis suppressor gene, KAI1, by etoposide is mediated by p53 and c-Jun genes. (PubMed id 10913345)9 Mashimo T....Watabe K. (2000)
    208. Identification of the rat homologue of KAI1 and its expression in Dunning rat prostate cancers. (PubMed id 9831222)9 Suzuki H....Isaacs J.T. (1998)
    209. The tetraspanin protein CD82 associates with both free HLA class I heavy chain and heterodimeric beta 2-microglobulin complexes. (PubMed id 9058814)9 Lagaudriere-Gesbert C....Conjeaud H. (1997)
    210. Expression of tetra-spans transmembrane family (CD9, CD37, CD53, CD63, CD81 and CD82) in normal and neoplastic human keratinocytes: an association of CD9 with alpha 3 beta 1 integrin. (PubMed id 9470900)9 Okochi H....Furue M. (1997)
    211. Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells. (PubMed id 1738199)9 Fukudome K....Yoshie O. (1992)
    212. Genistein induces the metastasis suppressor kangai-1 which mediates its anti-invasive effects in TRAMP cancer cells. (PubMed id 17658479)9 El Touny L.H. and Banerjee P.P. (2007)
    213. KAI1, CAR, and Smad4 expression in the progression of colorectal tumor. (PubMed id 11480790)9 Mikami T....Munakata A. (2001)
    214. Downregulation of CD9 protein expression is associate d with aggressive behavior of oral squamous cell carcinoma. (PubMed id 20060356)9 Buim M.E....Soares F.A. (2010)
    215. BCAR1 expression in prostate cancer: association with 16q23 LOH status, tumor progression and EGFR/KAI1 staining. (PubMed id 17192874)9 Fromont G....Cussenot O. (2007)
    216. Tumour suppressor gene expression correlates with gastric cancer prognosis. (PubMed id 12692839)9 Lee H.S....Kim W.H. (2003)
    217. Absence of p53-dependent induction of the metastatic suppressor KAI1 gene after DNA damage. (PubMed id 10828889)9 Duriez C....Puisieux A. (2000)
    218. Suppression of telomerase, reexpression of KAI1, and abrogation of tumorigenicity by nerve growth factor in prostate cancer cell lines. (PubMed id 10353759)9 Sigala S....Spano P. (1999)
    219. [Expression of tumor metastasis suppressor gene KAI1/CD82 in human cancer cell lines with different metastasis potential] (PubMed id 11715465)9 Li S....Zhong H. (1999)
    220. Expression of KAI1 in paraffin-embedded normal, hyperplastic and neoplastic prostate and prostate carcinoma cell lines. (PubMed id 9589471)9 Ward J.M....Barrett J.C. (1998)
    221. Decreased expression of the metastasis suppressor gene KAI1 in gastric cancer. (PubMed id 9719466)9 Hinoda Y....Imai K. (1998)
    222. IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells. (PubMed id 9121765)9 Hobeika A.C....Johnson H.M. (1997)
    223. Glycosynaptic microdomains controlling tumor cell phe notype through alteration of cell growth, adhesion, and motility. (PubMed id 19874824)9 Hakomori S.I. (2010)
    224. Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories. (PubMed id 18403052)9 Konietzko U....Nitsch R.M. (2010)
    225. Tetraspanin gene expression levels as potential biomarkers for malignancy of gingival squamous cell carcinoma. (PubMed id 19330835)9 Hirano C....Takagi R. (2009)
    226. Characterization of a novel telomerase-immortalized h uman endometrial stromal cell line, St-T1b. (PubMed id 19619280)9 Samalecos A....Gellersen B. (2009)
    227. [Regulatory mechanism of malignant behavior of endometriosis mediated by puerarin] (PubMed id 19134456)9 Yu C.Q....Shen W. (2009)
    228. Comparative analysis of protein expressions in primary and metastatic gastric carcinomas. (PubMed id 18835621)9 Kim J.H....Kim W.H. (2009)
    229. Chfr is linked to tumour metastasis through the downregulation of HDAC1. (PubMed id 19182791)9 Oh Y.M.... Seol J.H. (2009)
    230. Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. (PubMed id 19587294)9 Xu D.... Hemler M.E. (2009)
    231. KITENIN increases invasion and migration of mouse squamous cancer cells and promotes pulmonary metastasis in a mouse squamous tumor model. (PubMed id 19166844)9 Lee J.K....Kim K.K. (2009)
    232. Tetraspanins regulate cell-to-cell transmission of HI V-1. (PubMed id 19602278)9 Krementsov D.N....Thali M. (2009)
    233. [Effect of metastasis suppressor gene KAI1 on the proliferation and invasive ability of cervical carcinoma cells] (PubMed id 19024306)9 Ouyang Y.W....Wang X. (2008)
    234. A novel function of CD82/KAI-1 on E-cadherin-mediated homophilic cellular adhesion of cancer cells. (PubMed id 18395972)9 Abe M....Shirasuna K. (2008)
    235. Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control. (PubMed id 18259215)9 Diop S.B....Saurin A.J. (2008)
    236. Tetraspanin CD151 regulates glycosylation of (alpha)3(beta)1 integrin. (PubMed id 18852263)9 Baldwin G....Berditchevski F. (2008)
    237. Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription. (PubMed id 18559276)9 Waldron E....Pietrzik C.U. (2008)
    238. The role of metastasis suppressor genes in metastatic dormancy. (PubMed id 18834404)9 Horak C.E....Steeg P.S. (2008)
    239. [Expression of nm23 and KAI1 and their clinical significance in primary gall bladder carcinoma] (PubMed id 18681326)9 Jiang W.X....Fang J.P. (2008)
    240. Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a 'regulated' transcriptional role. (PubMed id 18764939)9 Giliberto L....D'Adamio L. (2008)
    241. Expression of motility-related protein MRP1/CD9, N-cadherin, E-cadherin, alpha-catenin and beta-catenin in retinoblastoma. (PubMed id 17316610)9 Mohan A....Krishnakumar S. (2007)
    242. Tumor-endothelial cell interactions: therapeutic potential. (PubMed id 17498748)9 Iiizumi M....Watabe K. (2007)
    243. Lyso-GM3, its dimer, and multimer: their synthesis, and their effect on epidermal growth factor-induced receptor tyrosine kinase. (PubMed id 17638075)9 Murozuka Y....Hakomori S.I. (2007)
    244. Expression and function of transmembrane-4 superfamily (tetraspanin) proteins in osteoclasts: reciprocal roles of Tspan-5 and NET-6 during osteoclastogenesis. (PubMed id 17965585)9 Iwai K....Saeki Y. (2007)
    245. CDw78 defines MHC class II-peptide complexes that require Ii chain-dependent lysosomal trafficking, not localization to a specific tetraspanin membrane microdomain. (PubMed id 17015731)9 Poloso N.J....Roche P.A. (2006)
    246. Cytoskeleton rearrangement induced by tetraspanin eng agement modulates the activation of T and NK cells. (PubMed id 16552713)9 Crotta S....Wack A. (2006)
    247. Characterization of an antibody that can detect the Kai1/CD82 murine metastasis suppressor. (PubMed id 16372335)9 Custer M.C....Barrett J.C. (2006)
    248. The DARC side of metastasis: shining a light on KAI1-mediated metastasis suppression in the vascular tunnel. (PubMed id 16959609)9 Zijlstra A. and Quigley J.P. (2006)
    249. Promoter hypermethylation of tetraspanin members contributes to their silencing in myeloma cell lines. (PubMed id 16113057)9 Drucker L....Lishner M. (2006)
    250. Immunophenotypic analysis of human articular chondrocytes: changes in surface markers associated with cell expansion in monolayer culture. (PubMed id 15389573)9 Diaz-Romero J....Mainil-Varlet P. (2005)
    251. [Influence of KAI1 gene on the growth and invasion of human hepatocellular carcinoma MHCC97-H cells] (PubMed id 16092995)9 Si S.H....Zhou P. (2005)
    252. Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma. (PubMed id 15014022)9 Lee H.S....Kim W.H. (2004)
    253. Expression of tetraspanins in peripheral blood leukocytes: a comparison between normal and infectious conditions. (PubMed id 15304003)9 Tohami T....Lishner M. (2004)
    254. [The mechanism of KAI1 gene in inhibition of metastasis of primary pancreatic cancer] (PubMed id 15182508)9 Guo X.Z....Wu C.Y. (2004)
    255. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. (PubMed id 15331662)9 von Rotz R.C....Konietzko U. (2004)
    256. Down-regulation of KAI1/CD82 protein expression in oral cancer correlates with reduced disease free survival and overall patient survival. (PubMed id 15312688)9 Farhadieh R.D....Jacobson I.V. (2004)
    257. Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer. (PubMed id 12569360)9 Funakoshi T....Kawase I. (2003)
    258. Potential role for CD63 in CCR5-mediated human immunodeficiency virus type 1 infection of macrophages. (PubMed id 12610138)9 von Lindern J.J....O'Brien W.A. (2003)
    259. A physical and functional link between cholesterol and tetraspanins. (PubMed id 12938224)9 Charrin S....Rubinstein E. (2003)

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    Entrez Gene: 3732 HGNC: 6210 AceView: KAI1 Ensembl:ENSG00000085117 euGenes: HUgn3732
    ECgene: CD82 Kegg: 3732 H-InvDB: CD82

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    PharmGKB entry for CD82 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD82 Genetics and Cytogenetics in Oncology and Haematology

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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