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CD82 Gene

protein-coding   GIFtS: 61
GCID: GC11P044586

CD82 Molecule

(Previous names: kangai 1 (suppression of tumorigenicity 6, prostate; CD82...)
(Previous symbols: ST6, KAI1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD82 Molecule1 2     R2 Leukocyte Antigen1
KAI11 2 3 5     Suppression Of Tumorigenicity 61
ST61 2 3 5     4F92
CD82 Antigen1 2 3     C332
SAR22 3 5     GR152
Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2
Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4))1 2
     R22
Inducible Membrane Protein R22 3     tetraspanin-272
Metastasis Suppressor Kangai-12 3     tspan-272
IA42 3     Tetraspanin-273
TSPAN272 3     Tspan-273
C33 Antigen2 3     Suppressor Of Tumorigenicity 6 Protein3

External Ids:    HGNC: 62101   Entrez Gene: 37322   Ensembl: ENSG000000851177   OMIM: 6006235   UniProtKB: P277013   

Export aliases for CD82 gene to outside databases

Previous GC identifers: GC11P044544 GC11P044296


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD82 Gene:
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4
superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and
can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are
strongly correlated, and the loss of expression of these two proteins is associated with poor survival for
prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been
found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD82 Gene:
CD82 (CD82 molecule) is a protein-coding gene. Diseases associated with CD82 include prostate cancer, and facial paralysis. An important paralog of this gene is TSPAN2.

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701
Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Wiki entry for CD82 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD82 gene promoter:
         AP-1   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD82 promoter sequence
   Search Chromatin IP Primers for CD82

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD82


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

CD82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD82 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P044586:  view genomic region     (about GC identifiers)

Start:
44,585,977 bp from pter      End:
44,641,913 bp from pter
Size:
55,937 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD82_HUMAN, P27701 (See protein sequence)
Recommended Name: CD82 antigen  
Size: 267 amino acids; 29626 Da
Subunit: Interacts directly with IGSF8
Secondary accessions: D3DQN6 E9PC70 Q7Z2D4 Q7Z5N2
Alternative splicing: 2 isoforms:  P27701-1   P27701-2   

Explore the universe of human proteins at neXtProt for CD82: NX_P27701

Explore proteomics data for CD82 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys190
  • Glycosylation2 at Asn129, Asn157, Asn198
  • Modification sites at PhosphoSitePlus

  • See CD82 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020015.1  NP_002222.1  

    ENSEMBL proteins: 
     ENSP00000435682   ENSP00000227155   ENSP00000339686   ENSP00000431767   ENSP00000435661  
     ENSP00000433151   ENSP00000436403   ENSP00000433804   ENSP00000433788   ENSP00000433036  

    CD82 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CD82
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CD82
    GenScript Custom Purified and Recombinant Proteins Services for CD82
    Novus Biologicals CD82 Proteins
    Novus Biologicals CD82 Lysates
    Sino Biological Recombinant Protein for CD82
    Sino Biological Cell Lysate for CD82
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CD82 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD82 (CD82/Kai-1)
    Cell Signaling Technology (CST) Antibodies for CD82 
    OriGene Antibodies for CD82
    OriGene Custom Antibody Services for CD82
    Novus Biologicals CD82 Antibodies
    Abcam antibodies for CD82
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CD82
    LSBio Antibodies in human, mouse, rat for CD82

    CD82 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD82
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD82
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P27701

    ProtoNet protein and cluster: P27701

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: CD82_HUMAN, P27701
    Similarity: Belongs to the tetraspanin (TM4SF) family


    CD82 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD82_HUMAN, P27701
    Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15205336
         
    CD82 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD82:
     Increased cilium length after   Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD82
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD82

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD82
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD82

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CD82 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CD82:
    hsa-miR-338-5p hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmidCD82 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD82
    Predesigned siRNA for gene silencing in human, mouse, rat CD82

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD82

    Clone
    Products:
         
    OriGene clones in human, mouse for CD82 (see all 13)
    OriGene ORF clones in mouse, rat for CD82
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD82 (NM_002231)
    Sino Biological Human cDNA Clone for CD82
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD82
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD82

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD82
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD82 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD82_HUMAN, P27701: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    endosome1
    extracellular1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS7754374
    GO:0005887integral component of plasma membrane TAS1842498
    GO:0016021integral component of membrane ----
    GO:0070062extracellular vesicular exosome IDA19199708

    CD82 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD82 About    
    See pathways by source

    SuperPathContained pathways About
    1p53 signaling pathway
    p53 signaling pathway0.41
    2Lymphocyte Signaling
    Lymphocyte Signaling
    3Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    4Direct p53 effectors
    Direct p53 effectors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CD82
        Lymphocyte Signaling

    2 BioSystems Pathways for CD82
        Integrated Pancreatic Cancer Pathway
    Direct p53 effectors



    1 Kegg Pathway  (Kegg details for CD82):
        p53 signaling pathway


    CD82 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CD82: 
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD82

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD82 (P277011, 3 ENSP000002271554) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000239329P280683, ENSP000003936464I2D: score=1 STRING: ENSP00000393646
    ENSG00000242092P280683, ENSP000003787234I2D: score=1 STRING: ENSP00000378723
    ENSG00000206308P019033, ENSP000003727464I2D: score=2 STRING: ENSP00000372746
    HLA-DRAP019033, ENSP000003787864I2D: score=2 STRING: ENSP00000378786
    ENSG00000226264P280683I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD82

    5 Novoseek inferred chemical compound relationships for CD82 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    at-61 83.6 1 9041184 (1)
    digitonin 29.5 1 12938224 (1)
    tyrosine 16 6 17215249 (4), 18395972 (1), 15454569 (1)
    cholesterol 0 4 12938224 (1), 15454569 (1)
    paraffin 0 1 15783050 (1)



    CD82 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD82 gene (2 alternative transcripts): 
    NM_001024844.1  NM_002231.3  

    Unigene Cluster for CD82:

    CD82 molecule
    Hs.527778  [show with all ESTs]
    Unigene Representative Sequence: NM_002231
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526958 ENST00000227155(uc001myc.3 uc001myd.3) ENST00000342935
    ENST00000532544 ENST00000529277 ENST00000525210 ENST00000525898 ENST00000527737
    ENST00000524704 ENST00000525813 ENST00000529853 ENST00000530601 ENST00000530931
    ENST00000524750
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD82 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CD82:
    hsa-miR-338-5p hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmidCD82 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD82
    Predesigned siRNA for gene silencing in human, mouse, rat CD82
    Clone
    Products:
         
    OriGene clones in human, mouse for CD82 (see all 13)
    OriGene ORF clones in mouse, rat for CD82
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD82 (NM_002231)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD82
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD82
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD82
    OriGene qSTAR qPCR primer pairs in human, mouse for CD82
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD82
      QuantiTect SYBR Green Assays in human, mouse, rat CD82
      QuantiFast Probe-based Assays in human, mouse, rat CD82

    Additional mRNA sequence: 

    AK225410.1 AK225708.1 AK312677.1 AY303776.1 BC000726.2 BC001821.2 BT019761.1 BT019762.1 
    CR407650.1 CR542255.1 S48196.1 U20770.1 

    19 DOTS entries:

    DT.100793427  DT.313063  DT.97844941  DT.100793432  DT.120712758  DT.120712722  DT.92442010  DT.100793426 
    DT.120712724  DT.91742256  DT.100793430  DT.120712748  DT.120712751  DT.40261002  DT.95076548  DT.95076555 
    DT.120712720  DT.120753710  DT.95315953 

    Selected AceView cDNA sequences (see all 268):

    BI753805 BE871165 BU785446 AU119042 BE349302 BU785750 BM353004 BU196310 
    AI354379 CR593263 BE205860 CR609000 CR615871 BU185132 BE293674 AW168332 
    BG759651 BM914425 CR606617 BP366951 BM473622 AU077255 BG654786 BM999843 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD82 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                    -     -                 -                                             
    SP2:                    -     -                 -     -                                       
    SP3:                          -                 -                                             
    SP4:                                            -                                             
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CD82

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD82 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGGTGC
    CD82 Expression
    About this image


    CD82 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; non-germinal center cells   
     
     Epithelial Cells (Uncategorized)
             tonsil ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebellum
     
     Thymus (Hematopoietic System)
             Thymus
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
    CD82 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD82 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.527778

    UniProtKB/Swiss-Prot: CD82_HUMAN, P27701
    Tissue specificity: Lymphoid specific

        Pathway & Disease-focused RT2 Profiler PCR Array including CD82: 
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD82
    OriGene qSTAR qPCR primer pairs in human, mouse for CD82
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD82
    QuantiTect SYBR Green Assays in human, mouse, rat CD82
    QuantiFast Probe-based Assays in human, mouse, rat CD82
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CD82 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd821 , 5 CD82 antigen1, 5 79.45(n)1
    76.69(a)1
      2 (51.62 cM)5
    125211  NM_001271431.11  NP_001258360.11 
     934191115 
    chicken
    (Gallus gallus)
    Aves CD821 CD82 molecule 64.36(n)
    61.54(a)
      423172  NM_001008470.1  NP_001008470.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    65(a)
    40(a)
    1 ↔ many
    1 ↔ many
    1(46098567-46152689)
    GL343557.1(328922-329948)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240832 Xenopus laevis transcribed sequence with weak similarity more 76.08(n)    BJ061882.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054586.12   -- 71.75(n)    BC054586.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp66E1 Tetraspanin 66E 49.17(n)
    30.32(a)
      39017  NM_079261.5  NP_523985.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-81 tsp-8 44.54(n)
    32.38(a)
      181567  NM_078044.5  NP_510445.1 


    ENSEMBL Gene Tree for CD82 (if available)
    TreeFam Gene Tree for CD82 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD82 gene
    TSPAN22  CD92  TSPAN12  CD372  TSPAN92  CD532  TSPAN182  CD812  
    TSPAN42  TSPAN82  
    Selected SIMAP similar genes for CD82 using alignment to 10 protein entries:     CD82_HUMAN (see all proteins) (see all similar genes):
    TSPAN18    CD37    BTCC-1    CD81    CD9    TSPAN19
    TSPAN4    CD53    CD151    TSPAN2    TSPAN11    TSPAN5
    TSPAN1    TSPAN9    TSPAN17    TM4SF2    TSPAN7    TM4SF9

    CD82 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD82 (see all 1236)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411712661,2
    C--44326750(+) AAAAA-/GAATTT 2 -- int10--------
    rs122811841,2
    C,F--44329262(+) CTCTTG/CTTGTC 2 -- int14Minor allele frequency- C:0.16NA CSA WA 242
    rs122241741,2
    C,H--44513646(+) tctgcC/Tataca 2 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1168926241,2
    C,F--44513667(+) CACCCC/GCAGCT 2 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1436699671,2
    --44513893(+) ACTGCC/TGGGTT 2 -- us2k10--------
    rs794033001,2
    F--44513943(+) GAATGC/TTATGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1812916241,2
    --44513991(+) ATGTAC/TGGCAT 2 -- us2k10--------
    rs1850225611,2
    --44514064(+) AGATCA/GGTATG 2 -- us2k10--------
    rs1465714621,2
    --44514108(+) TTAAGA/GGCTCA 2 -- us2k10--------
    rs124195391,2
    C,H--44514171(+) GCTACT/CTAGGT 2 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for CD82 (44585977 - 44641913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD82:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522766CNV Loss19592680
    nsv897308CNV Loss21882294
    nsv525321CNV Gain19592680
    nsv897309CNV Gain21882294
    nsv897306CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CD82
    DNA2.0 Custom Variant and Variant Library Synthesis for CD82

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600623   
    OMIM disorders: 176807  
    Selected diseases for CD82 (see all 51):    
    About MalaCards
    prostate cancer    facial paralysis    gallbladder adenocarcinoma    cervical cancer
    renal oncocytoma    bladder carcinoma    newcastle disease    prostatitis
    oral cancer    chromophobe renal cell carcinoma    human t-cell leukemia virus type 1    pancreatic cancer
    cervical squamous cell carcinoma    cervicitis    laryngitis    estrogen-receptor negative breast cancer
    laryngeal carcinoma    squamous cell carcinoma    laryngeal squamous cell carcinoma    papillary carcinoma

    3 diseases from the University of Copenhagen DISEASES database for CD82:
    Facial paralysis     Carcinoma     Prostate cancer

    CD82 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CD82 gene (see all 43)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 74.8 303 18028322 (6), 12753720 (6), 8813131 (6), 17283532 (6) (see all 99)
    prostate cancer 59 80 10440748 (7), 8813131 (5), 9254900 (5), 11572762 (4) (see all 36)
    cancer 52.8 100 9671393 (4), 11331321 (3), 9699525 (3), 10440748 (2) (see all 52)
    pancreatic cancer 51.3 39 15944768 (5), 18286698 (5), 19489224 (4), 8895737 (4) (see all 12)
    allelic loss 48.5 12 8813131 (5), 11895916 (1), 9126478 (1), 9254900 (1) (see all 5)
    tumors 47.7 161 12684410 (5), 10568187 (5), 10873402 (5), 9736732 (5) (see all 62)
    primary tumor 44.6 23 11895916 (2), 10582691 (2), 17308076 (2), 15592684 (1) (see all 11)
    bladder cancer 40.4 27 17982617 (4), 10767717 (3), 10840154 (3), 9815782 (3) (see all 8)
    carcinoma 35.7 35 15259074 (6), 18575327 (3), 12747469 (2), 19024519 (2) (see all 16)
    metastatic cancer 35.7 4 16271511 (1), 11715465 (1)

    Genetic Association Database (GAD): CD82
    Human Genome Epidemiology (HuGE) Navigator: CD82 (1 document)

    Export disorders for CD82 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CD82 gene, integrated from 10 sources (see all 289) (see top 10):
    (articles sorted by number of sources associating them with CD82)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human KAI1 metastasis-suppressor gene. (PubMed id 9126478)1, 2, 9 Dong J.T.... Isaacs J.T. (Genomics 1997)
    2. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. (PubMed id 7754374)1, 2, 9 Dong J.T. and Barrett J.C. (Science 1995)
    3. C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. (PubMed id 1401919)1, 2, 9 Imai T.... Yoshie O. (J. Immunol. 1992)
    4. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PubMed id 22443383)1, 4 Oudot-Mellakh T....Morange P.E. (Br. J. Haematol. 2012)
    5. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PubMed id 12750295)1, 2 Zhang X.A.... Liu L. (Cancer Res. 2003)
    6. A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23. (PubMed id 1842498)1, 2 Gaugitsch H.W.... Baumruker T. (Eur. J. Immunol. 1991)
    7. High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis. (PubMed id 11895916)1, 9 Uzawa K....Tanzawa H. (Clin. Cancer Res. 2002)
    8. Loss of KAI1 expression in the progression of colorectal cancer. (PubMed id 10582691)1, 9 Lombardi D.P....Barrett J.C. (Cancer Res. 1999)
    9. CD82, and CD63 in thyroid cancer. (PubMed id 15375577)1, 9 Chen Z....Hoang-Vu C. (Int. J. Mol. Med. 2004)
    10. [Role of tumor metastasis suppressor gene KAI1 in development of colorectal cancer]. (PubMed id 12753720)1, 9 Yang J....Liu L.M. (Ai Zheng 2003)
    11. KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer. (PubMed id 18712725)1, 9 Christgen M....Lehmann U. (Int. J. Cancer 2008)
    12. Expression of the metastasis suppressor KAI1 in decidual cells at the human maternal-fetal interface: Regulation and functional implications. (PubMed id 17200188)1, 9 Gellersen B....Bamberger A.M. (Am. J. Pathol. 2007)
    13. KAI1 metastasis suppressor protein is down-regulated during the progression of human endometrial cancer. (PubMed id 12684410)1, 9 Liu F.S....Chiou L.C. (Clin. Cancer Res. 2003)
    14. An alternatively spliced KAI1 mRNA is expressed at low levels in human bladder cancers and bladder cancer cell lines and is not associated with invasive behaviour. (PubMed id 17982617)1, 9 Jackson P....Grimm M.O. (Oncol. Rep. 2007)
    15. Transcriptional and translational modulation of KAI1 expression in ductal carcinoma of the breast and the prognostic significance. (PubMed id 19148553)1, 9 Malik F.A....Jiang W.G. (Int. J. Mol. Med. 2009)
    16. [Expression of nm23 and KAI1 and their clinical significance in gallbladder adenocarcinoma]. (PubMed id 19024519)1, 9 Jiang W.X....Fang J.P. (Zhonghua Zhong Liu Za Zhi 2008)
    17. [Expression of KAI1 gene in human laryngeal carcinoma and its clinical significance]. (PubMed id 15996322)1, 9 Bai W.L....Gao H. (Zhonghua Zhong Liu Za Zhi 2005)
    18. Decreased expression of KAI1 metastasis suppressor gene is a recurrence predictor in primary pTa and pT1 urothelial bladder carcinoma. (PubMed id 14706010)1, 9 Su J.S....Kawamura J. (Int. J. Urol. 2004)
    19. Relationship between expression of KAI1 metastasis suppressor gene, mRNA levels and p53 in human bladder and prostate cancer cell lines. (PubMed id 12474542)1, 9 Jackson P....Russell P.J. (Urol. Oncol. 2002)
    20. Effect of expressional alteration of KAI1 on breast cancer cell growth, adhesion, migration and invasion. (PubMed id 19656997)1, 9 Malik F.A....Jiang W.G. (amp 2009)
    21. [Role of KAI1 gene expression and loss of heterozygosity of KAI1 in metastatic potential and prognosis of pancreatic cancer]. (PubMed id 19489224)1, 9 Fan L.X....Zhang Y. (Zhonghua Bing Li Xue Za Zhi 2009)
    22. KAI1 gene suppresses invasion and metastasis of hepatocellular carcinoma MHCC97-H cells in vitro and in animal models. (PubMed id 18028322)1, 9 Yang J.M....Ye Z.Y. (Liver Int. 2008)
    23. KAI1 gene expression in colonic carcinoma and its clinical significances. (PubMed id 15259074)1, 9 Wu D.H....Ding Y.Q. (World J. Gastroenterol. 2004)
    24. Expression of KAI1/CD82 in distant metastases from estrogen receptor-negative breast cancer. (PubMed id 19549254)1, 9 Christgen M....Lehmann U. (Cancer Sci. 2009)
    25. Tumor suppressor KAI1 affects integrin alphavbeta3-mediated ovarian cancer cell adhesion, motility, and proliferation. (PubMed id 19371633)1, 9 Ruseva Z....Reuning U. (Exp. Cell Res. 2009)
    26. Phorbol ester enhances KAI1 transcription by recruiting Tip60/Pontin complexes. (PubMed id 19048121)1, 9 Rowe A....Jackson P. (Neoplasia 2008)
    27. [Relationship between the expressions of KaI1, nm23, ETS-1, VEGF and microvascular density and clinical significance in nasopharyngeal carcinoma]. (PubMed id 17283532)1, 9 He S.Q. and Zhang W.Y. (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2006)
    28. KAI1 expression in thyroid neoplasms: its linkage with clinicopathologic features in papillary carcinoma. (PubMed id 12747469)1, 9 Ito Y....Miyauchi A. (Pathol. Res. Pract. 2003)
    29. Expression and clinical significance of p53, JunB and KAI1/CD82 in human hepatocellular carcinoma. (PubMed id 19666408)1, 9 Guo C....Yang X. (amp 2009)
    30. Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse. (PubMed id 17215249)1, 9 Todeschini A.R....Hakomori S.I. (J. Biol. Chem. 2007)
    31. Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion. (PubMed id 15557282)1, 9 He B....Zhang X.A. (J. Biol. Chem. 2005)
    32. Expression of tetraspanin adaptor proteins below defined threshold values is associated with in vitro invasiveness of mammary carcinoma cells. (PubMed id 12579280)1, 9 Sauer G....Deissler H. (Oncol. Rep. 2003)
    33. The inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag protein. (PubMed id 17166843)1, 9 Mazurov D....Derse D. (J. Biol. Chem. 2007)
    34. KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer. (PubMed id 15205336)1, 9 Lee J.H....Kim K.K. (Cancer Res. 2004)
    35. Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR. (PubMed id 14576349)1, 9 Odintsova E....Berditchevski F. (J. Cell. Sci. 2003)
    36. Role of tumor metastasis suppressor gene KAI1 in digestive tract carcinomas and cancer cells. (PubMed id 12955496)1, 9 Wu Q....Su W.J. (Cell Tissue Res. 2003)
    37. Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling. (PubMed id 20144992)1, 9 Danglot L....Galli T. (J. Cell. Sci. 2010)
    38. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. (PubMed id 15592684)1, 9 Stark A.M....Held-Feindt J. (J. Cancer Res. Clin. Oncol. 2005)
    39. Regulation of urokinase receptor proteolytic function by the tetraspanin CD82. (PubMed id 15677461)1, 9 Bass R....Ellis V. (J. Biol. Chem. 2005)
    40. Effects of KAI1 gene on growth and invasion of human hepatocellular carcinoma MHCC97-H cells. (PubMed id 15237426)1, 9 Si S.H....Zhou P. (World J. Gastroenterol. 2004)
    41. The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation. (PubMed id 18037895)1, 9 Tsai Y.C....Weissman A.M. (Nat. Med. 2007)
    42. CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82. (PubMed id 9804823)1, 9 HorvA!th G....Rubinstein E. (J. Biol. Chem. 1998)
    43. Expression of nm23, KAI1 and spiral computed tomography findings in primary gallbladder carcinoma. (PubMed id 19951590)1, 9 Jiang W.X....Wang P.J. (Chin. Med. J. 2009)
    44. Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling. (PubMed id 19755988)1, 9 Zismanov V....Drucker L. (Br. J. Cancer 2009)
    45. Down-regulation of the metastasis suppressor protein KAI1/CD82 correlates with occurrence of metastasis, prognosis and presence of HPV DNA in human penile squamous cell carcinoma. (PubMed id 18305955)1, 9 Protzel C....Giebel J. (Virchows Arch. 2008)
    46. Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor. (PubMed id 18981120)1, 9 Arduise C....Le Naour F. (J. Immunol. 2008)
    47. KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2. (PubMed id 18622748)1, 9 Mu Z....Guo X. (Sci. China, C, Life Sci. 2008)
    48. [Effect of metastasis suppressor gene KAI1 on adhesion of hepatocellular carcinoma cell line MHCC97-H]. (PubMed id 17672940)1, 9 Yu Y....Liu W. (Ai Zheng 2007)
    49. Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1. (PubMed id 16735575)1, 9 Nydegger S....Thali M. (J. Cell Biol. 2006)
    50. A novel link between SUMO modification and cancer metastasis. (PubMed id 16861889)1, 9 Baek S.H. (Cell Cycle 2006)
    51. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. (PubMed id 15829968)1, 9 Kim J.H....Baek S.H. (Nature 2005)
    52. Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation. (PubMed id 15454569)1, 9 Delaguillaumie A....Conjeaud H. (J. Cell. Sci. 2004)
    53. Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathway. (PubMed id 12642901)1, 9 Jee B....Lee H. (amp 2003)
    54. Distinctive signaling pathways through CD82 and beta1 integrins in human T cells. (PubMed id 11981820)1, 9 Iwata S....Morimoto C. (Eur. J. Immunol. 2002)
    55. CD82 regulates STAT5/IL-10 and supports survival of acute myelogenous leukemia cells. (PubMed id 23797738)1 Nishioka C....Yokoyama A. (Int. J. Cancer 2014)
    56. KAI1/CD82 and cyclin D1 as biomarkers of invasion, metastasis and prognosis of laryngeal squamous cell carcinoma. (PubMed id 23696923)1 Zhang B....Jin D. (Int J Clin Exp Pathol 2013)
    57. Metastasis suppressor tetraspanin CD82/KAI1 regulates ubiquitylation of epidermal growth factor receptor. (PubMed id 23897813)1 Odintsova E....Berditchevski F. (J. Biol. Chem. 2013)
    58. Human endometrial stromal cell-trophoblast interactions: mutual stimulation of chemotactic migration and promigratory roles of cell surface molecules CD82 and CEACAM1. (PubMed id 23349235)1 Gellersen B....Bamberger A.M. (Biol. Reprod. 2013)
    59. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PubMed id 23449627)1 Cousminer D.L....WidAcn E. (Hum. Mol. Genet. 2013)
    60. CD34a8_/CD38a8> acute myelogenous leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells. (PubMed id 23055153)1 Nishioka C....Yokoyama A. (Int. J. Cancer 2013)
    61. Tetraspanins CD81 and CD82 facilitate I+4I^1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1. (PubMed id 23704882)1 Spring F.A....Anstee D.J. (PLoS ONE 2013)
    62. N-Glycosylation pattern of recombinant human CD82 (KAI1), a tumor-associated membrane protein. (PubMed id 22123080)1 Wang H....Yang P. (J Proteomics 2012)
    63. Tetraspanin CD82 inhibits protrusion and retraction in cell movement by attenuating the plasma membrane-dependent actin organization. (PubMed id 23251627)1 Liu W.M....Zhang X.A. (PLoS ONE 2012)
    64. Expression and clinical significance of CD82/KAI1 and E-cadherin in non-small cell lung cancer. (PubMed id 23102249)1 Shiwu W.U....Yisheng T. (Arch Iran Med 2012)
    65. [Relationship among the expression of lymphatic vessel density, microvessel density, carcinoembryonic antigenic mRNA, KAI1, and Kiss-1, and prognosis in patients with non-small cell lung cancer]. (PubMed id 22681921)1 Wang G....Cheng Z. (Zhongguo Fei Ai Za Zhi 2012)
    66. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    67. CD82 expression alters with human endometrial cycles and affects the uterine endometrial receptivity in vitro. (PubMed id 22393164)1 Wei X....Yan Q. (Exp. Biol. Med. (Maywood) 2012)
    68. Utility of immunohistochemical analysis of KAI1, epithelial-specific antigen, and epithelial-related antigen for distinction of chromophobe renal cell carcinoma, an eosinophilic variant from renal oncocytoma. (PubMed id 22718295)1 Ohe C....Uemura Y. (Med Mol Morphol 2012)
    69. KAI1 suppresses HIF-1I+ and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer. (PubMed id 22390300)1 Park J.J....Lee M. (BMC Cancer 2012)
    70. An inverse relationship between KAI1 expression, invasive ability, and MMP-2 expression and activity in bladder cancer cell lines. (PubMed id 20864363)1 You J....Jackson P. (Urol. Oncol. 2012)
    71. CD82 inhibits canonical Wnt signalling by controlling the cellular distribution of I^-catenin in carcinoma cells. (PubMed id 23076981)1 Chigita S....Shirasuna K. (Int. J. Oncol. 2012)
    72. Expression of CD82 in human trophoblast and its role in trophoblast invasion. (PubMed id 22679510)1 Zhang Q....Tan Y. (PLoS ONE 2012)
    73. CsA improves the trophoblasts invasiveness through strengthening the cross-talk of trophoblasts and decidual stromal cells mediated by CXCL12 and CD82 in early pregnancy. (PubMed id 22670173)1 Meng Y.H....Li D.J. (Int J Clin Exp Pathol 2012)
    74. Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma. (PubMed id 21521534)1 Chen Z....Hoang-Vu C. (World J Surg Oncol 2011)
    75. [Expression of CD82/KAI1 and HIF-1I+ in non-small cell lung cancer and their relationship to vasculogenic mimicry]. (PubMed id 22152691)1 Wu S....Tao Y. (Zhongguo Fei Ai Za Zhi 2011)
    76. Expressional alterations and transcript isoforms of metastasis suppressor genes (KAI1 and KiSS1) in breast cancer patients. (PubMed id 22320993)1 Mooez S....Khan A. (Asian Pac. J. Cancer Prev. 2011)
    77. KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer. (PubMed id 21454613)1 Liu W....Watabe K. (J. Biol. Chem. 2011)
    78. KAI1 inhibits HGF-induced invasion of pancreatic cancer by sphingosine kinase activity. (PubMed id 21459729)1 Liu X....Wang L.S. (amp 2011)
    79. Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and I^1 integrin activation. (PubMed id 21691075)1 Lee H.A....Lee H. (Cell. Physiol. Biochem. 2011)
    80. Lack of germ line changes in KISS1 and KAI1 genes in sporadic head and neck cancer patients of Pakistani origin. (PubMed id 22320990)1 Nazir M....Kayani M.A. (Asian Pac. J. Cancer Prev. 2011)
    81. HIF-2 directly activates CD82 gene expression in endothelial cells. (PubMed id 21382346)1 Nagao K. and Oka K. (Biochem. Biophys. Res. Commun. 2011)
    82. The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification. (PubMed id 21149584)1 Artavanis-Tsakonas K....Vyas J.M. (Infect. Immun. 2011)
    83. Overexpression of KAI1 induces autophagy and increases MiaPaCa-2 cell survival through the phosphorylation of extracellular signal-regulated kinases. (PubMed id 21168384)1 Wu C.Y....Wang H. (Biochem. Biophys. Res. Commun. 2011)
    84. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    85. [Correlation of CD82 and hTERT expressions and HPV infection with penile cancer]. (PubMed id 21961244)1 Zhai J.P....Xu K.X. (Zhonghua Nan Ke Xue 2011)
    86. CD82 gene suppression in endometrial stromal cells leads to increase of the cell invasiveness in the endometriotic milieu. (PubMed id 21685244)1 Li M.Q....Li D.J. (J. Mol. Endocrinol. 2011)
    87. Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in primary oral squamous cell carcinoma and corresponding metastases in cervical lymph nodes: association with the metastasis suppressor CD82. (PubMed id 21965773)1 Kawasaki G....Umeda M. (Anticancer Res. 2011)
    88. Dissecting the diverse functions of the metastasis suppressor CD82/KAI1. (PubMed id 21875585)1 Tsai Y.C. and Weissman A.M. (FEBS Lett. 2011)
    89. The DSCs-expressed CD82 controls the invasiveness of trophoblast cells via integrinbeta1/MAPK/MAPK3/1 signaling pathway in human first-trimester pregnancy. (PubMed id 20075392)1 Li M.Q....Li D.J. (Biol. Reprod. 2010)
    90. A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase. (PubMed id 20089858)1 Joshi B....Nabi I.R. (J. Biol. Chem. 2010)
    91. Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/beta-catenin signal via ISGylation of beta-catenin. (PubMed id 20581239)1 Lee J.H....Kim K.K. (Gut 2010)
    92. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    93. A role for CD81 on the late steps of HIV-1 replication in a chronically infected T cell line. (PubMed id 19284574)1 Grigorov B....Muriaux D. (Retrovirology 2009)
    94. Control of cell motility by interaction of gangliosides, tetraspanins, and epidermal growth factor receptor in A431 versus KB epidermoid tumor cells. (PubMed id 19559406)1 Park S.Y....Hakomori S.I. (Carbohydr. Res. 2009)
    95. Identifying CD82 (KAI1) as a marker for human chromophobe renal cell carcinoma. (PubMed id 20002769)1 Yusenko M.V. and Kovacs G. (Histopathology 2009)
    96. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PubMed id 19199708)1 Gonzalez-Begne M....Yates J.R. (J. Proteome Res. 2009)
    97. Human immunodeficiency virus type-1 gag and host vesicular trafficking pathways. (PubMed id 20012524)1 Chu H....Spearman P. (Curr. Top. Microbiol. Immunol. 2009)
    98. KAI1/CD82 decreases Rac1 expression and cell proliferation through PI3K/Akt/mTOR pathway in H1299 lung carcinoma cells. (PubMed id 19107873)1 Choi U.J....Lee K.H. (Cell Biochem. Funct. 2009)
    99. Decreased expression of KAI1/CD82 metastasis suppressor gene is associated with loss of heterozygosity in melanoma cell lines. (PubMed id 19082457)1 Kim Y.I....Lee M.H. (Oncol. Rep. 2009)
    100. Human Discs Large is a new negative regulator of human immunodeficiency virus-1 infectivity. (PubMed id 18946087)1 Perugi F....Pique C. (Mol. Biol. Cell 2009)
    101. CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts. (PubMed id 19497983)1 Xu C....Zhang X.A. (FASEB J. 2009)
    102. Transmembrane interactions are needed for KAI1/CD82-mediated suppression of cancer invasion and metastasis. (PubMed id 19116362)1 Bari R....Zhang X.A. (Am. J. Pathol. 2009)
    103. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    104. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)2 Wollscheid B.... Watts J.D. (Nat. Biotechnol. 2009)
    105. Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours. (PubMed id 19680475)1 Yusenko M.V....Kovacs G. (Int. J. Biol. Sci. 2009)
    106. Resolution of de novo HIV production and trafficking in immature dendritic cells. (PubMed id 18059278)1 Turville S.G....Robbiani M. (Nat. Methods 2008)
    107. HIV-1 replication in dendritic cells occurs through a tetraspanin-containing compartment enriched in AP-3. (PubMed id 18034776)1 Garcia E....Piguet V. (Traffic 2008)
    108. Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins. (PubMed id 17989173)1 Sato K....Koyanagi Y. (J. Virol. 2008)
    109. Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. (PubMed id 18272501)1 Todeschini A.R....Hakomori S.I. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    110. Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas. (PubMed id 18415123)1 Briese J....Bamberger A.M. (Virchows Arch. 2008)
    111. HIV-1 buds predominantly at the plasma membrane of primary human macrophages. (PubMed id 17381240)1 Welsch S....KrAousslich H.G. (PLoS Pathog. 2007)
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    151. KAI1, a new metastasis suppressor gene, is reduced in metastatic hepatocellular carcinoma. (PubMed id 9828210)9 Guo X.Z....BA1chler M.W. (Hepatology 1998)
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    247. Expression of motility-related protein MRP1/CD9, N-cadherin, E-cadherin, alpha-catenin and beta-catenin in retinoblastoma. (PubMed id 17316610)9 Mohan A....Krishnakumar S. (Exp. Eye Res. 2007)
    248. Tumor-endothelial cell interactions: therapeutic potential. (PubMed id 17498748)9 Iiizumi M....Watabe K. (Microvasc. Res. 2007)
    249. Lyso-GM3, its dimer, and multimer: their synthesis, and their effect on epidermal growth factor-induced receptor tyrosine kinase. (PubMed id 17638075)9 Murozuka Y....Hakomori S.I. (Glycoconj. J. 2007)
    250. Expression and function of transmembrane-4 superfamily (tetraspanin) proteins in osteoclasts: reciprocal roles of Tspan-5 and NET-6 during osteoclastogenesis. (PubMed id 17965585)9 Iwai K....Saeki Y. (Allergol Int 2007)
    251. CDw78 defines MHC class II-peptide complexes that require Ii chain-dependent lysosomal trafficking, not localization to a specific tetraspanin membrane microdomain. (PubMed id 17015731)9 Poloso N.J....Roche P.A. (J. Immunol. 2006)
    252. Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells. (PubMed id 16552713)9 Crotta S....Wack A. (Eur. J. Immunol. 2006)
    253. Characterization of an antibody that can detect the Kai1/CD82 murine metastasis suppressor. (PubMed id 16372335)9 Custer M.C....Barrett J.C. (Prostate 2006)
    254. The DARC side of metastasis: shining a light on KAI1-mediated metastasis suppression in the vascular tunnel. (PubMed id 16959609)9 Zijlstra A. and Quigley J.P. (Cancer Cell 2006)
    255. Promoter hypermethylation of tetraspanin members contributes to their silencing in myeloma cell lines. (PubMed id 16113057)9 Drucker L....Lishner M. (Carcinogenesis 2006)
    256. Immunophenotypic analysis of human articular chondrocytes: changes in surface markers associated with cell expansion in monolayer culture. (PubMed id 15389573)9 Diaz-Romero J....Mainil-Varlet P. (J. Cell. Physiol. 2005)
    257. [Influence of KAI1 gene on the growth and invasion of human hepatocellular carcinoma MHCC97-H cells]. (PubMed id 16092995)9 Si S.H....Zhou P. (Zhonghua Gan Zang Bing Za Zhi 2005)
    258. Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma. (PubMed id 15014022)9 Lee H.S....Kim W.H. (Clin. Cancer Res. 2004)
    259. Expression of tetraspanins in peripheral blood leukocytes: a comparison between normal and infectious conditions. (PubMed id 15304003)9 Tohami T....Lishner M. (Tissue Antigens 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3732 HGNC: 6210 AceView: KAI1 Ensembl:ENSG00000085117 euGenes: HUgn3732
    ECgene: CD82 Kegg: 3732 H-InvDB: CD82

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD82 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD82 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD82 gene:
    Search GeneIP for patents involving CD82

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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