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Aliases for CD82 Gene

Aliases for CD82 Gene

  • CD82 Molecule 2 3
  • CD82 Antigen 2 3 4
  • KAI1 3 4 6
  • SAR2 3 4 6
  • ST6 3 4 6
  • Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4)) 2 3
  • Metastasis Suppressor Kangai-1 3 4
  • Inducible Membrane Protein R2 3 4
  • Tetraspanin-27 3 4
  • C33 Antigen 3 4
  • Tspan-27 3 4
  • TSPAN27 3 4
  • IA4 3 4
  • Suppressor Of Tumorigenicity 6 Protein 4
  • Suppression Of Tumorigenicity 6 2
  • R2 Leukocyte Antigen 2
  • GR15 3
  • 4F9 3
  • C33 3
  • R2 3

External Ids for CD82 Gene

Previous Symbols for CD82 Gene

  • ST6
  • KAI1

Summaries for CD82 Gene

Entrez Gene Summary for CD82 Gene

  • This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD82 Gene

CD82 (CD82 Molecule) is a Protein Coding gene. Diseases associated with CD82 include facial paralysis and prostate cancer. Among its related pathways are Integrated Pancreatic Cancer Pathway and Direct p53 effectors. An important paralog of this gene is TSPAN9.

UniProtKB/Swiss-Prot for CD82 Gene

  • Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Wiki entry for CD82 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD82 Gene

Genomics for CD82 Gene

Genomic Location for CD82 Gene

Start:
44,564,427 bp from pter
End:
44,620,363 bp from pter
Size:
55,937 bases
Orientation:
Plus strand

Genomic View for CD82 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD82 Gene

Regulatory Elements for CD82 Gene

Proteins for CD82 Gene

  • Protein details for CD82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27701-CD82_HUMAN
    Recommended name:
    CD82 antigen
    Protein Accession:
    P27701
    Secondary Accessions:
    • D3DQN6
    • E9PC70
    • Q7Z2D4
    • Q7Z5N2

    Protein attributes for CD82 Gene

    Size:
    267 amino acids
    Molecular mass:
    29626 Da
    Quaternary structure:
    • Interacts directly with IGSF8.

    Alternative splice isoforms for CD82 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD82 Gene

Proteomics data for CD82 Gene at MOPED

Post-translational modifications for CD82 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys190
  • Glycosylation at Asn129, Asn157, and Asn198

No data available for DME Specific Peptides for CD82 Gene

Domains for CD82 Gene

Gene Families for CD82 Gene

HGNC:
  • CD :CD molecules
  • TSPAN :Tetraspanins

Suggested Antigen Peptide Sequences for CD82 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27701

UniProtKB/Swiss-Prot:

CD82_HUMAN
Family:
  • Belongs to the tetraspanin (TM4SF) family.:
    • P27701
genes like me logo Genes that share domains with CD82: view

Function for CD82 Gene

Molecular function for CD82 Gene

UniProtKB/Swiss-Prot Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Ontology (GO) - Molecular Function for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15205336
genes like me logo Genes that share ontologies with CD82: view

Phenotypes for CD82 Gene

genes like me logo Genes that share phenotypes with CD82: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CD82 Gene

Localization for CD82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD82 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD82 Gene COMPARTMENTS Subcellular localization image for CD82 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
endosome 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 7754374
GO:0005887 integral component of plasma membrane TAS 1842498
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CD82: view

Pathways for CD82 Gene

genes like me logo Genes that share pathways with CD82: view

Pathways by source for CD82 Gene

1 Cell Signaling Technology pathway for CD82 Gene
2 BioSystems pathways for CD82 Gene
1 KEGG pathway for CD82 Gene

Gene Ontology (GO) - Biological Process for CD82 Gene

None

Compounds for CD82 Gene

(5) Novoseek inferred chemical compound relationships for CD82 Gene

Compound -log(P) Hits PubMed IDs
at-61 83.6 1
digitonin 29.5 1
tyrosine 16 6
cholesterol 0 2
paraffin 0 1
genes like me logo Genes that share compounds with CD82: view

Transcripts for CD82 Gene

Unigene Clusters for CD82 Gene

CD82 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD82 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7: - -

Relevant External Links for CD82 Gene

GeneLoc Exon Structure for
CD82
ECgene alternative splicing isoforms for
CD82

Expression for CD82 Gene

mRNA expression in normal human tissues for CD82 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD82 Gene

This gene is overexpressed in Whole Blood (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD82 Gene

SOURCE GeneReport for Unigene cluster for CD82 Gene Hs.527778

mRNA Expression by UniProt/SwissProt for CD82 Gene

P27701-CD82_HUMAN
Tissue specificity: Lymphoid specific
genes like me logo Genes that share expressions with CD82: view

Orthologs for CD82 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD82 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD82 35
  • 99.5 (n)
  • 99.63 (a)
CD82 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD82 36
  • 77 (a)
OneToOne
LOC100335281 35
  • 84.77 (n)
  • 77.15 (a)
dog
(Canis familiaris)
Mammalia CD82 35
  • 86.64 (n)
  • 82.02 (a)
CD82 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd82 35
  • 79.45 (n)
  • 76.69 (a)
Cd82 16
Cd82 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD82 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD82 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd82 35
  • 78.57 (n)
  • 76.69 (a)
chicken
(Gallus gallus)
Aves CD82 35
  • 64.36 (n)
  • 61.54 (a)
CD82 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24083 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cd82 35
  • 65.6 (n)
  • 63.2 (a)
MGC76214 35
zebrafish
(Danio rerio)
Actinopterygii cd82a 36
  • 53 (a)
OneToMany
cd82b 35
  • 63.24 (n)
  • 57.71 (a)
cd82b 36
  • 55 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004861 35
  • 44.54 (n)
  • 31.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp66E 35
  • 49.17 (n)
  • 30.32 (a)
Tsp66E 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-11 36
  • 23 (a)
ManyToMany
tsp-13 36
  • 17 (a)
ManyToMany
tsp-8 35
  • 44.54 (n)
  • 32.38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
Species with no ortholog for CD82:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD82 Gene

ENSEMBL:
Gene Tree for CD82 (if available)
TreeFam:
Gene Tree for CD82 (if available)

Paralogs for CD82 Gene

Paralogs for CD82 Gene

genes like me logo Genes that share paralogs with CD82: view

Variants for CD82 Gene

Sequence variations from dbSNP and Humsavar for CD82 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs730129 -- 44,581,778(-) TCCTC(C/T)TAGAA intron-variant
rs744222 -- 44,582,047(-) TTCCC(A/G)CCACC intron-variant
rs744223 -- 44,582,059(-) TTGTG(A/C)CATTA intron-variant
rs744630 -- 44,582,341(+) AGGAA(C/T)CCTGT intron-variant
rs744631 -- 44,582,490(+) GGGTC(C/G)TAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD82 Gene

Variant ID Type Subtype PubMed ID
nsv897306 CNV Gain 21882294
nsv897308 CNV Loss 21882294
nsv525321 CNV Gain 19592680
nsv522766 CNV Loss 19592680
nsv897309 CNV Gain 21882294

Relevant External Links for CD82 Gene

HapMap Linkage Disequilibrium report
CD82

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD82 Gene

Disorders for CD82 Gene

(1) OMIM Diseases for CD82 Gene (600623)

(3) University of Copenhagen DISEASES for CD82 Gene

(43) Novoseek inferred disease relationships for CD82 Gene

Disease -log(P) Hits PubMed IDs
metastasis 74.8 222
prostate cancer 59 62
cancer 52.8 70
pancreatic cancer 51.3 34
allelic loss 48.5 9

Relevant External Links for CD82

Genetic Association Database (GAD)
CD82
Human Genome Epidemiology (HuGE) Navigator
CD82
genes like me logo Genes that share disorders with CD82: view

No data available for UniProtKB/Swiss-Prot for CD82 Gene

Publications for CD82 Gene

  1. Genomic organization of the human KAI1 metastasis-suppressor gene. (PMID: 9126478) Dong J.T. … Isaacs J.T. (Genomics 1997) 3 4 23
  2. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. (PMID: 7754374) Dong J.T. … Barrett J.C. (Science 1995) 3 4 23
  3. C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. (PMID: 1401919) Imai T. … Yoshie O. (J. Immunol. 1992) 3 4 23
  4. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. (PMID: 15592684) Stark A.M. … Held-Feindt J. (J. Cancer Res. Clin. Oncol. 2005) 3 23
  5. Regulation of urokinase receptor proteolytic function by the tetraspanin CD82. (PMID: 15677461) Bass R. … Ellis V. (J. Biol. Chem. 2005) 3 23

Products for CD82 Gene

  • Addgene plasmids for CD82

Sources for CD82 Gene

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