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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD82 Gene

protein-coding GIFtS: 57
GCID: GC11P044586

CD82 molecule

(Previous names: kangai 1 (suppression of tumorigenicity 6, prostate; CD82...)
(Previous symbols: ST6, KAI1)

Explore 59 diseases affiliated with
CD82 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD82 Molecule¹ ²		Metastasis Suppressor Kangai-1² ³
KAI1¹ ² ³ ⁵		C33 Antigen² ³
ST6¹ ² ³ ⁵		4F9²
IA4¹ ² ³		C33²
TSPAN27¹ ² ³		GR15²
CD82 Antigen¹ ² ³		Tetraspanin-27³
SAR2² ³ ⁵		Tspan-27³
R2¹ ²		Tetraspanin-27³
Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4))¹ ²		Tspan-27³
Inducible Membrane Protein R2² ³		Suppressor Of Tumorigenicity 6 Protein³

External Ids:	HGNC: 6210¹	Entrez Gene: 3732²	Ensembl: ENSG00000085117⁷	OMIM: 600623⁵	UniProtKB: P27701³

Export aliases for CD82 gene to outside databases

Previous GC identifers: GC11P044544 GC11P044296

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD82:

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily.

Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated

by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated,

and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two

alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701

Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Wiki entry for CD82

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD82 gene promoter:
AP-1 NF-kappaB1 NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD82 promoter sequence

Search SABiosciences Chromatin IP Primers for CD82

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD82

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2

CD82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD82 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P044586: view genomic region (about GC identifiers)

Start:	44,585,977 bp from pter	End:	44,641,913 bp from pter
Size:	55,937 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701 (See protein sequence)

Recommended Name: CD82 antigen

Size: 267 amino acids; 29626 Da

Subunit: Interacts directly with IGSF8

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: D3DQN6 E9PC70 Q7Z2D4 Q7Z5N2

Alternative splicing: 2 isoforms: P27701-1 P27701-2

Explore the universe of human proteins at neXtProt for CD82: NX_P27701

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P27701

CD82 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001020015.1 NP_002222.1

ENSEMBL proteins:

ENSP00000435682 ENSP00000227155 ENSP00000339686 ENSP00000431767 ENSP00000435661

ENSP00000433151 ENSP00000436403 ENSP00000433804 ENSP00000433788 ENSP00000433036

Human Recombinant Protein Products for CD82:

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	Novus Biologicals CD82 Proteins Novus Biologicals CD82 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD82

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	7754374
GO:0005887	integral to plasma membrane	TAS	1842498
GO:0016021	integral to membrane	--	--

CD82 for ontologies About GeneDecksing

CD82 Antibody Products:

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	ThermoFisher Antibodies for CD82

Assay Products for CD82:

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	Uscn ELISAs and CLIAs for CD82

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD82 for domains About GeneDecksing

4 InterPro domains/families:

IPR018499 Tetraspanin/Peripherin

IPR000301 Tetraspanin

IPR008952 Tetraspanin_EC2

IPR018503 Tetraspanin_CS

Graphical View of Domain Structure for InterPro Entry P27701

ProtoNet protein and cluster: P27701

1 Blocks protein family: IPB000301 Transmembrane four family signature

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701

Similarity: Belongs to the tetraspanin (TM4SF) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CD82_HUMAN, P27701

Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15205336

CD82 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CD82:

Increased cilium length after

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD82

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD82 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD82
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD82:
		hsa-miR-338-5p hsa-miR-3943
		SwitchGear 3'UTR luciferase reporter plasmid: CD82 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD82 (see all 7) OriGene shRNA RFP: CD82 OriGene siRNA: CD82
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CD82

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CD82
			Sirion Biotech Customized adenovirus for overexpression of CD82 Sirion Biotech Customized adenovirus for potent knockdown of CD82

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD82 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD82 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD82 (NM_002231)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD82

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		Sirion Biotech Customized stable knockdown cell line services for CD82 Sirion Biotech Customized inducible knockdown cell line services for CD82 Sirion Biotech Customized stable overexpressing cell line services for CD82 Sirion Biotech Customized inducible overexpressing cell line services for CD82

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Direct p53 effectors

Direct p53 effectors

1.00

p53 signaling pathway

p53 signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for CD82

Lymphocyte Signaling

3 BioSystems Pathways for CD82

	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Direct p53 effectors

1 Kegg Pathway (Kegg details for CD82):

p53 signaling pathway

CD82 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD82

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/37 Interacting proteins for CD82 (P27701^{1, 3} ENSP00000227155⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VANGL1	Q8TAA9¹^,³, ENSP00000310800⁴	EBI-682379,EBI-682393 I2D: score=2 STRING: ENSP00000310800
CD19	P15391³, ENSP00000313419⁴	I2D: score=2 STRING: ENSP00000313419
ERBB2	P04626³, ENSP00000269571⁴	I2D: score=2 STRING: ENSP00000269571
HLA-DRA	P01903³, ENSP00000378786⁴	I2D: score=2 STRING: ENSP00000378786
IGSF8	Q969P0³, ENSP00000316664⁴	I2D: score=2 STRING: ENSP00000316664

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD82 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD82
5 Novoseek chemical compound relationships for CD82 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
at-61	83.6	1	9041184 (1)
digitonin	29.5	1	12938224 (1)
tyrosine	16	6	17215249 (4), 18395972 (1), 15454569 (1)
cholesterol	0	4	12938224 (1), 15454569 (1)
paraffin	0	1	15783050 (1)

Search CenterWatch for drugs/clinical trials and news about CD82

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD82 gene (2 alternative transcripts):

NM_001024844.1 NM_002231.3

Unigene Cluster for CD82:

CD82 molecule

Hs.527778 [show with all ESTs]

Unigene Representative Sequence: NM_002231

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000526958 ENST00000227155(uc001myc.3 uc001myd.3) ENST00000342935

ENST00000532544 ENST00000529277 ENST00000525210 ENST00000525898 ENST00000527737

ENST00000524704 ENST00000525813 ENST00000529853 ENST00000530601 ENST00000530931

ENST00000524750

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD82 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD82
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD82:
		hsa-miR-338-5p hsa-miR-3943
		SwitchGear 3'UTR luciferase reporter plasmid: CD82 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD82 (see all 7) OriGene shRNA RFP: CD82 OriGene siRNA: CD82
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD82
		Sirion Biotech Custom design and validation of potent shRNA sequences against CD82

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD82 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD82 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD82

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD82 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD82
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD82

Additional cDNA sequence:

AK225410.1 AK225708.1 AK312677.1 AY303776.1 BC000726.2 BC001821.2 BT019761.1 BT019762.1

CR407650.1 CR542255.1 S48196.1 U20770.1

19 DOTS entries:

DT.100793427 DT.313063 DT.97844941 DT.100793432 DT.120712758 DT.120712722 DT.92442010 DT.100793426

DT.120712724 DT.91742256 DT.100793430 DT.120712748 DT.120712751 DT.40261002 DT.95076548 DT.95076555

DT.120712720 DT.120753710 DT.95315953

24/268 AceView cDNA sequences (see all 268):

BU185132 CR609000 BU785750 AW168332 CR593263 BE871165 BG759651 BM473622

BE349302 CR615871 BI753805 BE293674 BU785446 BG654786 BP366951 AU119042

CR606617 BE205860 BM914425 AU077255 AI354379 BU196310 BM353004 BQ688811

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CD82 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b
SP1:							-		-						-
SP2:							-		-						-		-
SP3:									-						-
SP4:															-
SP5:

ECgene alternative splicing isoforms for CD82

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD82 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAAGGTGC

About this image
See CD82 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD82

SOURCE GeneReport for Unigene cluster: Hs.527778

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701

Tissue specificity: Lymphoid specific

SABiosciences Expression via Pathway-Focused PCR Array including CD82:

Tumor Metastasis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CD82 gene from 6/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CD82¹	CD82 molecule	64.36(n) 61.54(a)		423172 NM_001008470.1 NP_001008470.1
lizard (Anolis carolinensis)	Reptilia	CD82⁶ --	--	63(a) 40(a)	1 ↔ many 1 ↔ many	1(46122410-46149569) GL343557.1(328922-329948)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24083²	Xenopus laevis transcribed sequence with weak similarity to protein spP27701 (H.sapiens) CD82_HUMAN CD82 antigen (Inducible membrane protein R2) (C33 antigen) (IA4) (Metastasis suppressor Kangai 1) (Suppressor of tumorigenicity-6) less	76.08(n)		BJ061882.1
zebrafish (Danio rerio)	Actinopterygii	BC054586.1²	--	71.75(n)		BC054586.1
fruit fly (Drosophila melanogaster)	Insecta	Tsp66E¹	Tetraspanin 66E	50.35(n) 32.34(a)		39017 NM_168298.1 NP_729423.1
worm (Caenorhabditis elegans)	Secernentea	tsp-8¹	Protein TSP-8	41.73(n) 30(a)		181567 NM_078044.4 NP_510445.1

ENSEMBL Gene Tree for CD82 (if available)
TreeFam Gene Tree for CD82 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD82 gene

CD151² TSPAN1² CD37² TSPAN6² TSPAN9² TSPAN3² CD63² CD53²

TSPAN18² TSPAN7² TSPAN4² TSPAN11² ENSG00000250349² TSPAN8²

18/23 SIMAP similar genes for CD82 using alignment to 10 protein entries: CD82_HUMAN (see all proteins) (see all similar genes):

TSPAN18 BTCC-1 CD81 CD37 CD9 TSPAN19

TSPAN4 CD53 TSPAN2 CD151 TSPAN11 TSPAN5

TSPAN1 TSPAN9 TSPAN17 TM4SF2 TSPAN7 TM4SF9

CD82 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12224174^1,2	C,H	--	44294433(+)	`TCTGCC/TATACA`	2	--	us2k¹		4		NS EA	418
rs79403300^1,2	F	--	44294730(+)	`GAATGC/TTATGA`	2	--	us2k¹		1		WA	118
rs12419539^1,2	C,H	--	44294958(+)	`GCTACT/CTAGGT`	2	--	us2k¹		1		NA	2
rs77461641^1,2	F	--	44295374(+)	`GAGGGC/TAGAGG`	2	--	us2k¹		1		EA	120
rs7933160^1,2	C,F	--	44295772(+)	`AGGGCT/AAGAAC`	2	--	us2k¹		1		WA	118
rs75333641^1,2	F	--	44296269(+)	`GACTCC/TGTAGC`	2	--	us2k¹		1		WA	118
rs11541048^1,2	C	--	44296502(+)	`AGTCCG/AACGCC`	2	--	ut5¹		2		NA	4
rs71490071^1,2	C,F	--	44296646(+)	`CTGCGG/ATCCGG`	2	--	int¹		4		NA	126
rs76166912^1,2		--	44297538(+)	`AAGGTA/GCCAGG`	2	--	int¹		0	--	--	--	--
rs4365036^1,2	C,F,A	--	44297571(-)	`AGCAGC/TTGTCA`	2	--	int¹		7		NA WA CSA	248

HapMap Linkage Disequilibrium report for CD82 (44585977 - 44641913 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD82: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD82

DNA2.0 Custom Variant and Variant Library Synthesis for CD82

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD82 for disorders           About GeneDecksing

OMIM gene information: 600623
OMIM disorders: 176807
20/59 diseases for CD82 (see all 59):    About MalaCards

prostatitis prostate cancer human t-cell leukemia virus type 1 squamous cell carcinoma

facial paralysis severe acute respiratory syndrome laryngeal squamous cell carcinoma oral squamous cell carcinoma

carcinoma renal oncocytoma esophageal squamous cell carcinoma cervical squamous cell carcinoma

transitional cell carcinoma newcastle disease bladder carcinoma cervicitis

intrahepatic cholangiocarcinoma epithelial ovarian cancer cervical cancer gallbladder adenocarcinoma

3 diseases from the University of Copenhagen DISEASES database for CD82:

Facial paralysis Prostate cancer Carcinoma

10/43 Novoseek disease relationships for CD82 gene (see all 43) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	74.8	303	18028322 (6), 12753720 (6), 8813131 (6), 17283532 (6) (see all 99)
prostate cancer	59	80	10440748 (7), 8813131 (5), 9254900 (5), 11572762 (4) (see all 36)
cancer	52.8	100	9671393 (4), 11331321 (3), 9699525 (3), 10440748 (2) (see all 52)
pancreatic cancer	51.3	39	15944768 (5), 18286698 (5), 19489224 (4), 8895737 (4) (see all 12)
allelic loss	48.5	12	8813131 (5), 11895916 (1), 9126478 (1), 9254900 (1) (see all 5)
tumors	47.7	161	12684410 (5), 10568187 (5), 10873402 (5), 9736732 (5) (see all 62)
primary tumor	44.6	23	11895916 (2), 10582691 (2), 17308076 (2), 15592684 (1) (see all 11)
bladder cancer	40.4	27	17982617 (4), 10767717 (3), 10840154 (3), 9815782 (3) (see all 8)
carcinoma	35.7	35	15259074 (6), 18575327 (3), 12747469 (2), 19024519 (2) (see all 16)
metastatic cancer	35.7	4	16271511 (1), 11715465 (1)

Human Genome Epidemiology (HuGE) Navigator: CD82 (1 document)

Export disorders for CD82 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD82 gene, integrated from 9 sources (see all 277):
(articles sorted by number of sources associating them with CD82)

Utopia: connect your pdf to the dynamic
world of online information

Genomic organization of the human KAI1 metastasis-suppressor gene. (PubMed id 9126478)^{1, 2, 9} Dong J.T.... Isaacs J.T. (1997)
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. (PubMed id 7754374)^{1, 2, 9} Dong J.T. and Barrett J.C. (1995)
C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. (PubMed id 1401919)^{1, 2, 9} Imai T.... Yoshie O. (1992)
EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PubMed id 12750295)^{1, 2} Zhang X.A.... Liu L. (2003)
A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23. (PubMed id 1842498)^{1, 2} Gaugitsch H.W.... Baumruker T. (1991)
High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis. (PubMed id 11895916)^{1, 9} Uzawa K....Tanzawa H. (2002)
Loss of KAI1 expression in the progression of colorectal cancer. (PubMed id 10582691)^{1, 9} Lombardi D.P....Barrett J.C. (1999)
CD82, and CD63 in thyroid cancer. (PubMed id 15375577)^{1, 9} Chen Z....Hoang-Vu C. (2004)
[Role of tumor metastasis suppressor gene KAI1 in development of colorectal cancer] (PubMed id 12753720)^{1, 9} Yang J....Liu L.M. (2003)
KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer. (PubMed id 18712725)^{1, 9} Christgen M....Lehmann U. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3732	HGNC: 6210	AceView: KAI1	Ensembl:ENSG00000085117	euGenes: HUgn3732
ECgene: CD82	Kegg: 3732	H-InvDB: CD82

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CD82	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD82	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CD82 gene
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Patent Information for CD82 gene:
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CD82 (Gene Symbol)
CD82 Molecule
KAI1
ST6
IA4
TSPAN27
CD82 Antigen
SAR2
R2
Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4))
Inducible Membrane Protein R2
Metastasis Suppressor Kangai-1
C33 Antigen
4F9
C33
GR15
Tetraspanin-27
Tspan-27
Tetraspanin-27
Tspan-27
Suppressor Of Tumorigenicity 6 Protein

Gastric Cancer
Melanoma
bladder cancer
Leukemia T-Cell
Colon Cancer
nonmetastatic
Carcinoma
LUNG CARCINOMA
Leukemia
PROSTATE CARCINOMA
epithelial tumor
Breast Cancer
NSCLC
Allelic Loss
primary tumor
metastatic cancer
invasive cervical cancer
Adenocarcinoma
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
Cancer
Pancreatic Cancer
Colorectal Carcinoma
Cancer Lung
GASTRIC CARCINOMA
Precancerous lesions
Adenoma
Colorectal Cancer
benign prostatic hyperplasia
Prostatic Intraepithelial Neoplasia
invasive cancer
solid tumor
Carcinoma Squamous Cell
Oral Cancer
immunodeficiency
BLADDER CARCINOMA
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prostate cancer
Tumors
liver metastases
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breast cancer metastatic

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