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Aliases for CD82 Gene

Aliases for CD82 Gene

  • CD82 Molecule 2 3 5
  • CD82 Antigen 2 3 4
  • Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4)) 2 3
  • Metastasis Suppressor Kangai-1 3 4
  • Inducible Membrane Protein R2 3 4
  • Tetraspanin-27 3 4
  • C33 Antigen 3 4
  • Tspan-27 3 4
  • TSPAN27 3 4
  • KAI1 3 4
  • SAR2 3 4
  • ST6 3 4
  • IA4 3 4
  • Suppressor Of Tumorigenicity 6 Protein 4
  • Suppression Of Tumorigenicity 6 2
  • R2 Leukocyte Antigen 2
  • GR15 3
  • 4F9 3
  • C33 3
  • R2 3

External Ids for CD82 Gene

Previous HGNC Symbols for CD82 Gene

  • ST6
  • KAI1

Previous GeneCards Identifiers for CD82 Gene

  • GC11P044544
  • GC11P044296

Summaries for CD82 Gene

Entrez Gene Summary for CD82 Gene

  • This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD82 Gene

CD82 (CD82 Molecule) is a Protein Coding gene. Diseases associated with CD82 include Prostate Cancer and Chromophobe Renal Cell Carcinoma. Among its related pathways are DNA Damage Response and Direct p53 effectors. An important paralog of this gene is CD37.

UniProtKB/Swiss-Prot for CD82 Gene

  • Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Gene Wiki entry for CD82 Gene

Additional gene information for CD82 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD82 Gene

Genomics for CD82 Gene

Regulatory Elements for CD82 Gene

Enhancers for CD82 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H044560 1.7 FANTOM5 ENCODE dbSUPER 25.3 +1.7 1699 10 HDGF PKNOX1 SIN3A GLI4 YY1 ZNF121 GLIS2 ZNF143 FOS ATF7 CD82 ALKBH3 SEC14L1P1 ENSG00000254693 ENSG00000255092 EXT2
GH11H044590 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.4 +30.1 30103 7 HDGF CTCF PKNOX1 EBF1 RELA YY1 POLR2A EED RUNX3 IKZF2 CD82 RPL34P22 ENSG00000254693
GH11H044606 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +46.8 46831 8 HDGF PKNOX1 SIN3A YBX1 ZNF143 ZNF207 FOS ATF7 RUNX3 ZNF623 CD82 TSPAN18 PRDM11 ENSG00000255092 RPL34P22
GH11H044572 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +11.9 11876 7 HDGF PKNOX1 BATF GATA2 EGR1 FOS RUNX3 IKZF2 EGR2 CBFB CD82 ENSG00000254693 ENSG00000255092 SEC14L1P1
GH11H044559 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13 -4.5 -4509 1 HDGF CHD4 BMI1 EBF1 BATF RELA POLR2A EED ZNF143 ATF7 CD82 ENSG00000254693 ENSG00000255092 GC11M044543
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD82 on UCSC Golden Path with GeneCards custom track

Promoters for CD82 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039304 1473 1801 FOXA2 YY1 GLIS2 SP3 NFYC NCOA1 REST ZNF592 SMARCA4 GLIS1

Genomic Location for CD82 Gene

Chromosome:
11
Start:
44,564,427 bp from pter
End:
44,620,363 bp from pter
Size:
55,937 bases
Orientation:
Plus strand

Genomic View for CD82 Gene

Genes around CD82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD82 Gene

Proteins for CD82 Gene

  • Protein details for CD82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27701-CD82_HUMAN
    Recommended name:
    CD82 antigen
    Protein Accession:
    P27701
    Secondary Accessions:
    • D3DQN6
    • E9PC70
    • Q7Z2D4
    • Q7Z5N2

    Protein attributes for CD82 Gene

    Size:
    267 amino acids
    Molecular mass:
    29626 Da
    Quaternary structure:
    • Interacts directly with IGSF8.

    Alternative splice isoforms for CD82 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD82 Gene

Post-translational modifications for CD82 Gene

  • Ubiquitination at posLast=190190
  • Glycosylation at posLast=129129, Asn157, and posLast=198198
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD82 (CD82)
  • Abcam antibodies for CD82

No data available for DME Specific Peptides for CD82 Gene

Domains & Families for CD82 Gene

Gene Families for CD82 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CD82 Gene

Graphical View of Domain Structure for InterPro Entry

P27701

UniProtKB/Swiss-Prot:

CD82_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD82: view

Function for CD82 Gene

Molecular function for CD82 Gene

UniProtKB/Swiss-Prot Function:
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Phenotypes From GWAS Catalog for CD82 Gene

Gene Ontology (GO) - Molecular Function for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15205336
genes like me logo Genes that share ontologies with CD82: view
genes like me logo Genes that share phenotypes with CD82: view

Animal Models for CD82 Gene

MGI Knock Outs for CD82:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD82

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD82
  • Applied Biological Materials Clones for CD82
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD82 Gene

Localization for CD82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD82 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD82 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
nucleus 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 7754374
GO:0005887 integral component of plasma membrane TAS 1842498
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CD82: view

Pathways & Interactions for CD82 Gene

genes like me logo Genes that share pathways with CD82: view

Pathways by source for CD82 Gene

1 Cell Signaling Technology pathway for CD82 Gene
1 BioSystems pathway for CD82 Gene
1 KEGG pathway for CD82 Gene

Gene Ontology (GO) - Biological Process for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with CD82: view

No data available for SIGNOR curated interactions for CD82 Gene

Drugs & Compounds for CD82 Gene

(2) Drugs for CD82 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CD82 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD82: view

Transcripts for CD82 Gene

Unigene Clusters for CD82 Gene

CD82 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD82
  • Applied Biological Materials Clones for CD82
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CD82 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7: - -

Relevant External Links for CD82 Gene

GeneLoc Exon Structure for
CD82
ECgene alternative splicing isoforms for
CD82

Expression for CD82 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD82 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD82 Gene

This gene is overexpressed in Whole Blood (x7.2).

Protein differential expression in normal tissues from HIPED for CD82 Gene

This gene is overexpressed in Nasal epithelium (54.6) and Amniocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD82 Gene



NURSA nuclear receptor signaling pathways regulating expression of CD82 Gene:

CD82

SOURCE GeneReport for Unigene cluster for CD82 Gene:

Hs.527778

mRNA Expression by UniProt/SwissProt for CD82 Gene:

P27701-CD82_HUMAN
Tissue specificity: Lymphoid specific.

Evidence on tissue expression from TISSUES for CD82 Gene

  • Intestine(4.6)
  • Blood(4.4)
  • Liver(4.4)
  • Lymph node(3.1)
  • Lung(2.8)
  • Nervous system(2.6)
  • Bone marrow(2.3)
  • Spleen(2.2)
  • Stomach(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CD82: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD82 Gene

Orthologs for CD82 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD82 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD82 33 34
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia CD82 33 34
  • 86.64 (n)
cow
(Bos Taurus)
Mammalia LOC100335281 33
  • 84.77 (n)
CD82 34
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd82 33 16 34
  • 79.45 (n)
rat
(Rattus norvegicus)
Mammalia Cd82 33
  • 78.57 (n)
oppossum
(Monodelphis domestica)
Mammalia CD82 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD82 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD82 33 34
  • 64.36 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cd82 33
  • 65.6 (n)
MGC76214 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24083 33
zebrafish
(Danio rerio)
Actinopterygii cd82b 33 34
  • 63.24 (n)
cd82a 34
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp66E 33 34
  • 49.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004861 33
  • 44.54 (n)
worm
(Caenorhabditis elegans)
Secernentea tsp-8 33
  • 44.54 (n)
tsp-11 34
  • 23 (a)
ManyToMany
tsp-13 34
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
ManyToMany
-- 34
  • 16 (a)
ManyToMany
Species where no ortholog for CD82 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD82 Gene

ENSEMBL:
Gene Tree for CD82 (if available)
TreeFam:
Gene Tree for CD82 (if available)

Paralogs for CD82 Gene

Variants for CD82 Gene

Sequence variations from dbSNP and Humsavar for CD82 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000000095 -- 44,565,674(+) CGACG(C/G)CGACT utr-variant-5-prime
rs1000024424 -- 44,602,264(+) CGATT(C/T)ACGGC intron-variant
rs1000091277 -- 44,579,669(+) ACCAG(C/T)GTTCC intron-variant
rs1000106516 -- 44,609,252(+) GCTCT(G/T)GGGCC intron-variant
rs1000140828 -- 44,586,406(+) GCTTC(G/T)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD82 Gene

Variant ID Type Subtype PubMed ID
esv3626163 CNV loss 21293372
nsv522766 CNV loss 19592680
nsv525321 CNV gain 19592680

Variation tolerance for CD82 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD82 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD82

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD82 Gene

Disorders for CD82 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CD82 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
chromophobe renal cell carcinoma
  • chromophobe adenocarcinoma
bladder cancer, somatic
  • bladder carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CD82 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD82

Genetic Association Database (GAD)
CD82
Human Genome Epidemiology (HuGE) Navigator
CD82
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD82
genes like me logo Genes that share disorders with CD82: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD82 Gene

Publications for CD82 Gene

  1. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PMID: 22443383) Oudot-Mellakh T … Morange PE (British journal of haematology 2012) 3 45 60
  2. Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling. (PMID: 20144992) Danglot L … Galli T (Journal of cell science 2010) 3 22 60
  3. Expression and clinical significance of p53, JunB and KAI1/CD82 in human hepatocellular carcinoma. (PMID: 19666408) Guo C … Yang X (Hepatobiliary & pancreatic diseases international : HBPD INT 2009) 3 22 60
  4. Effect of expressional alteration of KAI1 on breast cancer cell growth, adhesion, migration and invasion. (PMID: 19656997) Malik FA … Jiang WG (Cancer genomics & proteomics 2009) 3 22 60
  5. Expression of KAI1/CD82 in distant metastases from estrogen receptor-negative breast cancer. (PMID: 19549254) Christgen M … Lehmann U (Cancer science 2009) 3 22 60

Products for CD82 Gene

  • Addgene plasmids for CD82

Sources for CD82 Gene

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