CD82 Gene

Aliases
for CD82 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC11P044544 GC11P044296

Summaries
for CD82 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CD82 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000011.9  NT_009237.19  NC_018922.2  

SwitchGear Promoter luciferase reporter plasmid: CD82 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD82

CD82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P044586:  view genomic region     (about GC identifiers)

Proteins
for CD82 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CD82: NX_P27701

Explore proteomics data for CD82 at MOPED

Post-translational modifications: 

CD82 Human Recombinant Protein Products:

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	Novus Biologicals CD82 Proteins Novus Biologicals CD82 Lysates
	Sino Biological Recombinant Protein for CD82 Sino Biological Cell Lysate for CD82
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CD82
	Search GeneTex for Proteins for CD82
	antibodies-online proteins for CD82 (3 products)
	antibodies-online peptides for CD82

CD82 Antibody Products:

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	R&D Systems Antibodies for CD82 (CD82/Kai-1)
	Cell Signaling Technology (CST) Antibodies for CD82
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	Novus Biologicals CD82 Antibodies
	Abcam antibodies for CD82
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	ThermoFisher Antibodies for CD82
	antibodies-online antibodies for CD82 (91 products)

CD82 Assay Products:

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	OriGene Custom Assay Services for CD82
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	GenScript Custom Assay Services for CD82
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CD82
	antibodies-online kits for CD82 (6 products)

Domains /
Families
for CD82 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P27701

Find genes that share domains with CD82           About GenesLikeMe

Function
for CD82 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for CD82

miRNA Products:		Block miRNA regulation of human, mouse, rat CD82 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate CD82:
		hsa-miR-338-5p hsa-miR-3943
		SwitchGear 3'UTR luciferase reporter plasmid: CD82 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CD82
		Predesigned siRNA for gene silencing in human, mouse, rat CD82

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD82

Clone Products:		OriGene clones in human, mouse for CD82 (see all 13) OriGene ORF clones in mouse, rat for CD82 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD82 (NM_002231)
		Sino Biological Human cDNA Clone for CD82
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD82
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD82
		Addgene plasmids for CD82

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD82
		Browse ESI BIO Cell Lines and PureStem Progenitors for CD82

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82

Localization
for CD82 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	4
cytoskeleton	2
endosome	1
extracellular	1
nucleus	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for CD82 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for CD82 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CD82 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CD82 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CD82 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGAAGGTGC

About this image

Tonsil (Hematopoietic System)    fully expand to see all 3 entries
tonsil ; non-germinal center cells
Epithelial Cells (Uncategorized)
tonsil ; squamous epithelial cells
Brain (Nervous System)    fully expand to see all 2 entries
Myelinating Oligodendrocyte Cells Forebrain White Matter
Cerebellum
Thymus (Hematopoietic System)
Thymus
Neural Ectoderm (Nervous System)
Neural ectoderm cells

Primer Products:		OriGene qPCR primer pairs and template standards for CD82 OriGene qSTAR qPCR primer pairs in human, mouse for CD82
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD82
		QuantiTect SYBR Green Assays in human, mouse, rat CD82
		QuantiFast Probe-based Assays in human, mouse, rat CD82

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82

Orthologs
for CD82 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CD82 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CD82 gene

TSPAN2²  CD9²  TSPAN1²  CD37²  TSPAN9²  CD53²  TSPAN18²  CD81²  

TSPAN4²  TSPAN8²  

Selected SIMAP similar genes for CD82 using alignment to 10 protein entries:     CD82_HUMAN (see all proteins) (see all similar genes):

TSPAN18    CD37    BTCC-1    CD81    CD9    TSPAN19

TSPAN4    CD53    CD151    TSPAN2    TSPAN11    TSPAN5

TSPAN1    TSPAN9    TSPAN17    TM4SF2    TSPAN7    TM4SF9

Find genes that share paralogs with CD82           About GenesLikeMe

Genomic Variants
for CD82 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CD82 (see all 1236)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1411712661,2	C	--	44326750(+)	AAAAA-/GAATTT	2	--	int1		0	--	--	--	--
rs122811841,2	C,F	--	44329262(+)	CTCTTG/CTTGTC	2	--	int1		4		NA CSA WA	242
rs122241741,2	C,H	--	44513646(+)	tctgcC/Tataca	2	--	us2k1		4		NS EA	418
rs1168926241,2	C,F	--	44513667(+)	CACCCC/GCAGCT	2	--	us2k1		1		EA	120
rs1436699671,2		--	44513893(+)	ACTGCC/TGGGTT	2	--	us2k1		0	--	--	--	--
rs794033001,2	F	--	44513943(+)	GAATGC/TTATGA	2	--	us2k1		1		WA	118
rs1812916241,2		--	44513991(+)	ATGTAC/TGGCAT	2	--	us2k1		0	--	--	--	--
rs1850225611,2		--	44514064(+)	AGATCA/GGTATG	2	--	us2k1		0	--	--	--	--
rs1465714621,2		--	44514108(+)	TTAAGA/GGCTCA	2	--	us2k1		0	--	--	--	--
rs124195391,2	C,H	--	44514171(+)	GCTACT/CTAGGT	2	--	us2k1		1		NA	2

HapMap Linkage Disequilibrium report for CD82 (44585977 - 44641913 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CD82:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv522766	CNV	Loss	19592680
nsv897308	CNV	Loss	21882294
nsv525321	CNV	Gain	19592680
nsv897309	CNV	Gain	21882294
nsv897306	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing CD82

DNA2.0 Custom Variant and Variant Library Synthesis for CD82

Disorders / Diseases
for CD82 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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6 diseases for CD82

Selected Novoseek inferred disease relationships for CD82 gene (see all 43)    About this table

Publications
for CD82 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Genomic organization of the human KAI1 metastasis-suppressor gene. (PubMed id 9126478)^{1, 2, 9} Dong J.T.... Isaacs J.T. (Genomics 1997)
2. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. (PubMed id 7754374)^{1, 2, 9} Dong J.T. and Barrett J.C. (Science 1995)
3. C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. (PubMed id 1401919)^{1, 2, 9} Imai T.... Yoshie O. (J. Immunol. 1992)
4. Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PubMed id 22443383)^{1, 4} Oudot-Mellakh T....Morange P.E. (Br. J. Haematol. 2012)
5. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PubMed id 12750295)^{1, 2} Zhang X.A.... Liu L. (Cancer Res. 2003)
6. A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23. (PubMed id 1842498)^{1, 2} Gaugitsch H.W.... Baumruker T. (Eur. J. Immunol. 1991)
7. High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis. (PubMed id 11895916)^{1, 9} Uzawa K....Tanzawa H. (Clin. Cancer Res. 2002)
8. Loss of KAI1 expression in the progression of colorectal cancer. (PubMed id 10582691)^{1, 9} Lombardi D.P....Barrett J.C. (Cancer Res. 1999)
9. CD82, and CD63 in thyroid cancer. (PubMed id 15375577)^{1, 9} Chen Z....Hoang-Vu C. (Int. J. Mol. Med. 2004)
10. [Role of tumor metastasis suppressor gene KAI1 in development of colorectal cancer]. (PubMed id 12753720)^{1, 9} Yang J....Liu L.M. (Ai Zheng 2003)

External Searches for CD82 gene

Genome Databases showing CD82 gene

Other Databases showing CD82 gene

Specialized Databases showing CD82 gene

Products
for CD82 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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