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Set Analyses:

VarElect

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CD82 Gene

protein-coding GIFtS: 61
GCID: GC11P044586

CD82 Molecule

(Previous names: kangai 1 (suppression of tumorigenicity 6, prostate; CD82...)
(Previous symbols: ST6, KAI1)

Pneumococci & Pneumococcal Diseases Congress

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
CD82 Molecule¹ ²		R2 Leukocyte Antigen¹
KAI1¹ ² ³ ⁵		Suppression Of Tumorigenicity 6¹
ST6¹ ² ³ ⁵		4F9²
CD82 Antigen¹ ² ³		C33²
SAR2² ³ ⁵		GR15²
Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4))¹ ²		R2²
Inducible Membrane Protein R2² ³		tetraspanin-27²
Metastasis Suppressor Kangai-1² ³		tspan-27²
IA4² ³		Tetraspanin-27³
TSPAN27² ³		Tspan-27³
C33 Antigen² ³		Suppressor Of Tumorigenicity 6 Protein³

External Ids:	HGNC: 6210¹	Entrez Gene: 3732²	Ensembl: ENSG00000085117⁷	OMIM: 600623⁵	UniProtKB: P27701³

Export aliases for CD82 gene to outside databases

Previous GC identifers: GC11P044544 GC11P044296

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD82 Gene:

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4

superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and

can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are

strongly correlated, and the loss of expression of these two proteins is associated with poor survival for

prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been

found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD82 Gene:

CD82 (CD82 molecule) is a protein-coding gene. Diseases associated with CD82 include prostate cancer, and facial paralysis. An important paralog of this gene is TSPAN2.

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701

Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Wiki entry for CD82 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000011.10 NT_009237.19 NC_018922.2

Regulatory elements:

Regulatory transcription factor binding sites in the CD82 gene promoter:
AP-1 NF-kappaB1 NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD82 promoter sequence

Search Chromatin IP Primers for CD82

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD82

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11.2

CD82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD82 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P044586: view genomic region (about GC identifiers)

Start:	44,585,977 bp from pter	End:	44,641,913 bp from pter
Size:	55,937 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD82_HUMAN, P27701 (See protein sequence)

Recommended Name: CD82 antigen

Size: 267 amino acids; 29626 Da

Subunit: Interacts directly with IGSF8

Secondary accessions: D3DQN6 E9PC70 Q7Z2D4 Q7Z5N2

Alternative splicing: 2 isoforms: P27701-1 P27701-2

Explore the universe of human proteins at neXtProt for CD82: NX_P27701

Explore proteomics data for CD82 at MOPED

Post-translational modifications:

Ubiquitination² at Lys190

Glycosylation² at Asn129, Asn157, Asn198

Modification sites at PhosphoSitePlus

See CD82 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001020015.1 NP_002222.1

ENSEMBL proteins:

ENSP00000435682 ENSP00000227155 ENSP00000339686 ENSP00000431767 ENSP00000435661

ENSP00000433151 ENSP00000436403 ENSP00000433804 ENSP00000433788 ENSP00000433036

CD82 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for CD82 OriGene Custom MassSpec OriGene Custom Protein Services for CD82
	GenScript Custom Purified and Recombinant Proteins Services for CD82
	Novus Biologicals CD82 Proteins Novus Biologicals CD82 Lysates
	Sino Biological Recombinant Protein for CD82 Sino Biological Cell Lysate for CD82
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

CD82 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD82 (CD82/Kai-1)
	Cell Signaling Technology (CST) Antibodies for CD82
	OriGene Antibodies for CD82 OriGene Custom Antibody Services for CD82
	Novus Biologicals CD82 Antibodies
	Abcam antibodies for CD82
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CD82
	LSBio Antibodies in human, mouse, rat for CD82

CD82 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CD82
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD82
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CD: CD molecules

TSPAN: Tetraspanins

4 InterPro protein domains:

IPR018499 Tetraspanin/Peripherin

IPR000301 Tetraspanin

IPR008952 Tetraspanin_EC2

IPR018503 Tetraspanin_CS

Graphical View of Domain Structure for InterPro Entry P27701

ProtoNet protein and cluster: P27701

1 Blocks protein domain: IPB000301 Transmembrane four family signature

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701

Similarity: Belongs to the tetraspanin (TM4SF) family

CD82 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CD82_HUMAN, P27701

Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15205336

CD82 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CD82:

Increased cilium length after

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD82

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD82

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD82

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD82

miRNA Products:		Block miRNA regulation of human, mouse, rat CD82 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate CD82:
		hsa-miR-338-5p hsa-miR-3943
		SwitchGear 3'UTR luciferase reporter plasmid: CD82 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CD82
		Predesigned siRNA for gene silencing in human, mouse, rat CD82

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD82

Clone Products:		OriGene clones in human, mouse for CD82 (see all 13) OriGene ORF clones in mouse, rat for CD82 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD82 (NM_002231)
		Sino Biological Human cDNA Clone for CD82
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD82
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD82

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD82
		Browse ESI BIO Cell Lines and PureStem Progenitors for CD82

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CD82_HUMAN, P27701: Membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
cytoskeleton	2
endosome	1
extracellular	1
nucleus	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	7754374
GO:0005887	integral component of plasma membrane	TAS	1842498
GO:0016021	integral component of membrane	--	--
GO:0070062	extracellular vesicular exosome	IDA	19199708

CD82 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CD82 About

See pathways by source

SuperPath

Contained pathways About

p53 signaling pathway

p53 signaling pathway

0.41

Lymphocyte Signaling

Lymphocyte Signaling

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

Direct p53 effectors

Direct p53 effectors

Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for CD82

Lymphocyte Signaling

2 BioSystems Pathways for CD82

	Integrated Pancreatic Cancer Pathway
	Direct p53 effectors

1 Kegg Pathway (Kegg details for CD82):

p53 signaling pathway

CD82 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including CD82:

Tumor Metastasis in human mouse rat

Interactions:

GeneGlobe Interaction Network for CD82

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CD82 (P27701^{1, 3} ENSP00000227155⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000239329	P28068³, ENSP00000393646⁴	I2D: score=1 STRING: ENSP00000393646
ENSG00000242092	P28068³, ENSP00000378723⁴	I2D: score=1 STRING: ENSP00000378723
ENSG00000206308	P01903³, ENSP00000372746⁴	I2D: score=2 STRING: ENSP00000372746
HLA-DRA	P01903³, ENSP00000378786⁴	I2D: score=2 STRING: ENSP00000378786
ENSG00000226264	P28068³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CD82

5 Novoseek inferred chemical compound relationships for CD82 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
at-61	83.6	1	9041184 (1)
digitonin	29.5	1	12938224 (1)
tyrosine	16	6	17215249 (4), 18395972 (1), 15454569 (1)
cholesterol	0	4	12938224 (1), 15454569 (1)
paraffin	0	1	15783050 (1)

CD82 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CD82 gene (2 alternative transcripts):

NM_001024844.1 NM_002231.3

Unigene Cluster for CD82:

CD82 molecule

Hs.527778 [show with all ESTs]

Unigene Representative Sequence: NM_002231

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000526958 ENST00000227155(uc001myc.3 uc001myd.3) ENST00000342935

ENST00000532544 ENST00000529277 ENST00000525210 ENST00000525898 ENST00000527737

ENST00000524704 ENST00000525813 ENST00000529853 ENST00000530601 ENST00000530931

ENST00000524750

miRNA Products:		Block miRNA regulation of human, mouse, rat CD82 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate CD82:
		hsa-miR-338-5p hsa-miR-3943
		SwitchGear 3'UTR luciferase reporter plasmid: CD82 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CD82
		Predesigned siRNA for gene silencing in human, mouse, rat CD82

Clone Products:		OriGene clones in human, mouse for CD82 (see all 13) OriGene ORF clones in mouse, rat for CD82 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD82 (NM_002231)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD82
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD82

Primer Products:		OriGene qPCR primer pairs and template standards for CD82 OriGene qSTAR qPCR primer pairs in human, mouse for CD82
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CD82
		QuantiTect SYBR Green Assays in human, mouse, rat CD82
		QuantiFast Probe-based Assays in human, mouse, rat CD82

Additional mRNA sequence:

AK225410.1 AK225708.1 AK312677.1 AY303776.1 BC000726.2 BC001821.2 BT019761.1 BT019762.1

CR407650.1 CR542255.1 S48196.1 U20770.1

19 DOTS entries:

DT.100793427 DT.313063 DT.97844941 DT.100793432 DT.120712758 DT.120712722 DT.92442010 DT.100793426

DT.120712724 DT.91742256 DT.100793430 DT.120712748 DT.120712751 DT.40261002 DT.95076548 DT.95076555

DT.120712720 DT.120753710 DT.95315953

Selected AceView cDNA sequences (see all 268):

BI753805 BE871165 BU785446 AU119042 BE349302 BU785750 BM353004 BU196310

AI354379 CR593263 BE205860 CR609000 CR615871 BU185132 BE293674 AW168332

BG759651 BM914425 CR606617 BP366951 BM473622 AU077255 BG654786 BM999843

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD82 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b
SP1:							-		-						-
SP2:							-		-						-		-
SP3:									-						-
SP4:															-
SP5:

ECgene alternative splicing isoforms for CD82

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CD82 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGAAGGTGC

About this image

CD82 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 13) fully expand


Tonsil (Hematopoietic System) fully expand to see all 3 entries
tonsil ; non-germinal center cells

Epithelial Cells (Uncategorized)
tonsil ; squamous epithelial cells

Brain (Nervous System) fully expand to see all 2 entries
Myelinating Oligodendrocyte Cells Forebrain White Matter
Cerebellum

Thymus (Hematopoietic System)
Thymus

Neural Ectoderm (Nervous System)
Neural ectoderm cells

CD82 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CD82 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.527778

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701

Tissue specificity: Lymphoid specific

Pathway & Disease-focused RT² Profiler PCR Array including CD82:

Tumor Metastasis in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CD82 OriGene qSTAR qPCR primer pairs in human, mouse for CD82
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CD82
		QuantiTect SYBR Green Assays in human, mouse, rat CD82
		QuantiFast Probe-based Assays in human, mouse, rat CD82

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CD82 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd82^{1 , 5}	CD82 antigen^{1, 5}	79.45(n)¹ 76.69(a)¹		2 (51.62 cM)⁵ 12521¹ NM_001271431.1¹ NP_001258360.1¹ 93419111⁵
chicken (Gallus gallus)	Aves	CD82¹	CD82 molecule	64.36(n) 61.54(a)		423172 NM_001008470.1 NP_001008470.1
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	65(a) 40(a)	1 ↔ many 1 ↔ many	1(46098567-46152689) GL343557.1(328922-329948)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24083²	Xenopus laevis transcribed sequence with weak similarity more	76.08(n)		BJ061882.1
zebrafish (Danio rerio)	Actinopterygii	BC054586.1²	--	71.75(n)		BC054586.1
fruit fly (Drosophila melanogaster)	Insecta	Tsp66E¹	Tetraspanin 66E	49.17(n) 30.32(a)		39017 NM_079261.5 NP_523985.1
worm (Caenorhabditis elegans)	Secernentea	tsp-8¹	tsp-8	44.54(n) 32.38(a)		181567 NM_078044.5 NP_510445.1

ENSEMBL Gene Tree for CD82 (if available)
TreeFam Gene Tree for CD82 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CD82 gene

TSPAN2² CD9² TSPAN1² CD37² TSPAN9² CD53² TSPAN18² CD81²

TSPAN4² TSPAN8²

Selected SIMAP similar genes for CD82 using alignment to 10 protein entries: CD82_HUMAN (see all proteins) (see all similar genes):

TSPAN18 CD37 BTCC-1 CD81 CD9 TSPAN19

TSPAN4 CD53 CD151 TSPAN2 TSPAN11 TSPAN5

TSPAN1 TSPAN9 TSPAN17 TM4SF2 TSPAN7 TM4SF9

CD82 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141171266^1,2	C	--	44326750(+)	`AAAAA-/GAATTT`	2	--	int¹		0	--	--	--	--
rs12281184^1,2	C,F	--	44329262(+)	`CTCTTG/CTTGTC`	2	--	int¹		4		NA CSA WA	242
rs12224174^1,2	C,H	--	44513646(+)	`tctgcC/Tataca`	2	--	us2k¹		4		NS EA	418
rs116892624^1,2	C,F	--	44513667(+)	`CACCCC/GCAGCT`	2	--	us2k¹		1		EA	120
rs143669967^1,2		--	44513893(+)	`ACTGCC/TGGGTT`	2	--	us2k¹		0	--	--	--	--
rs79403300^1,2	F	--	44513943(+)	`GAATGC/TTATGA`	2	--	us2k¹		1		WA	118
rs181291624^1,2		--	44513991(+)	`ATGTAC/TGGCAT`	2	--	us2k¹		0	--	--	--	--
rs185022561^1,2		--	44514064(+)	`AGATCA/GGTATG`	2	--	us2k¹		0	--	--	--	--
rs146571462^1,2		--	44514108(+)	`TTAAGA/GGCTCA`	2	--	us2k¹		0	--	--	--	--
rs12419539^1,2	C,H	--	44514171(+)	`GCTACT/CTAGGT`	2	--	us2k¹		1		NA	2

HapMap Linkage Disequilibrium report for CD82 (44585977 - 44641913 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for CD82: About this table

Variant ID	Type	Subtype	PubMed ID
nsv522766	CNV	Loss	19592680
nsv897308	CNV	Loss	21882294
nsv525321	CNV	Gain	19592680
nsv897309	CNV	Gain	21882294
nsv897306	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing CD82

DNA2.0 Custom Variant and Variant Library Synthesis for CD82

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600623
OMIM disorders: 176807
Selected diseases for CD82 (see all 51):
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prostate cancer facial paralysis gallbladder adenocarcinoma cervical cancer

renal oncocytoma bladder carcinoma newcastle disease prostatitis

oral cancer chromophobe renal cell carcinoma human t-cell leukemia virus type 1 pancreatic cancer

cervical squamous cell carcinoma cervicitis laryngitis estrogen-receptor negative breast cancer

laryngeal carcinoma squamous cell carcinoma laryngeal squamous cell carcinoma papillary carcinoma

3 diseases from the University of Copenhagen DISEASES database for CD82:

Facial paralysis Carcinoma Prostate cancer

CD82 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Selected Novoseek inferred disease relationships for CD82 gene (see all 43) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	74.8	303	18028322 (6), 12753720 (6), 8813131 (6), 17283532 (6) (see all 99)
prostate cancer	59	80	10440748 (7), 8813131 (5), 9254900 (5), 11572762 (4) (see all 36)
cancer	52.8	100	9671393 (4), 11331321 (3), 9699525 (3), 10440748 (2) (see all 52)
pancreatic cancer	51.3	39	15944768 (5), 18286698 (5), 19489224 (4), 8895737 (4) (see all 12)
allelic loss	48.5	12	8813131 (5), 11895916 (1), 9126478 (1), 9254900 (1) (see all 5)
tumors	47.7	161	12684410 (5), 10568187 (5), 10873402 (5), 9736732 (5) (see all 62)
primary tumor	44.6	23	11895916 (2), 10582691 (2), 17308076 (2), 15592684 (1) (see all 11)
bladder cancer	40.4	27	17982617 (4), 10767717 (3), 10840154 (3), 9815782 (3) (see all 8)
carcinoma	35.7	35	15259074 (6), 18575327 (3), 12747469 (2), 19024519 (2) (see all 16)
metastatic cancer	35.7	4	16271511 (1), 11715465 (1)

Genetic Association Database (GAD): CD82
Human Genome Epidemiology (HuGE) Navigator: CD82 (1 document)

Export disorders for CD82 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CD82 gene, integrated from 10 sources (see all 289):
(articles sorted by number of sources associating them with CD82)

Utopia: connect your pdf to the dynamic
world of online information

Genomic organization of the human KAI1 metastasis-suppressor gene. (PubMed id 9126478)^{1, 2, 9} Dong J.T.... Isaacs J.T. (Genomics 1997)
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. (PubMed id 7754374)^{1, 2, 9} Dong J.T. and Barrett J.C. (Science 1995)
C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. (PubMed id 1401919)^{1, 2, 9} Imai T.... Yoshie O. (J. Immunol. 1992)
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project. (PubMed id 22443383)^{1, 4} Oudot-Mellakh T....Morange P.E. (Br. J. Haematol. 2012)
EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PubMed id 12750295)^{1, 2} Zhang X.A.... Liu L. (Cancer Res. 2003)
A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23. (PubMed id 1842498)^{1, 2} Gaugitsch H.W.... Baumruker T. (Eur. J. Immunol. 1991)
High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis. (PubMed id 11895916)^{1, 9} Uzawa K....Tanzawa H. (Clin. Cancer Res. 2002)
Loss of KAI1 expression in the progression of colorectal cancer. (PubMed id 10582691)^{1, 9} Lombardi D.P....Barrett J.C. (Cancer Res. 1999)
CD82, and CD63 in thyroid cancer. (PubMed id 15375577)^{1, 9} Chen Z....Hoang-Vu C. (Int. J. Mol. Med. 2004)
[Role of tumor metastasis suppressor gene KAI1 in development of colorectal cancer]. (PubMed id 12753720)^{1, 9} Yang J....Liu L.M. (Ai Zheng 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3732	HGNC: 6210	AceView: KAI1	Ensembl:ENSG00000085117	euGenes: HUgn3732
ECgene: CD82	Kegg: 3732	H-InvDB: CD82

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CD82	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD82	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CD82 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD82 gene:
Search GeneIP for patents involving CD82

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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CD82 (Gene Symbol)
CD82 Molecule
KAI1
ST6
CD82 Antigen
SAR2
Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4))
Inducible Membrane Protein R2
Metastasis Suppressor Kangai-1
IA4
TSPAN27
C33 Antigen
R2 Leukocyte Antigen
Suppression Of Tumorigenicity 6
4F9
C33
GR15
R2
tetraspanin-27
tspan-27
Tetraspanin-27
Tspan-27
Suppressor Of Tumorigenicity 6 Protein

Gastric Cancer
Melanoma
bladder cancer
Leukemia T-Cell
Colon Cancer
nonmetastatic
Carcinoma
LUNG CARCINOMA
Leukemia
PROSTATE CARCINOMA
epithelial tumor
Breast Cancer
NSCLC
Allelic Loss
primary tumor
metastatic cancer
invasive cervical cancer
Adenocarcinoma
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
Cancer
Pancreatic Cancer
Colorectal Carcinoma
Cancer Lung
GASTRIC CARCINOMA
Precancerous lesions
Adenoma
Colorectal Cancer
benign prostatic hyperplasia
Prostatic Intraepithelial Neoplasia
invasive cancer
solid tumor
Carcinoma Squamous Cell
Oral Cancer
immunodeficiency
BLADDER CARCINOMA
Cervical Cancer
prostate cancer
Tumors
liver metastases
Metastasis
Carcinoma Ductal
breast cancer metastatic

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