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Aliases for CD82 Gene

Aliases for CD82 Gene

  • CD82 Molecule 2 3
  • CD82 Antigen 2 3 4
  • KAI1 3 4 6
  • SAR2 3 4 6
  • ST6 3 4 6
  • Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte Antigen, Antigen Detected By Monoclonal And Antibody IA4)) 2 3
  • Metastasis Suppressor Kangai-1 3 4
  • Inducible Membrane Protein R2 3 4
  • Tetraspanin-27 3 4
  • C33 Antigen 3 4
  • Tspan-27 3 4
  • TSPAN27 3 4
  • IA4 3 4
  • Suppressor Of Tumorigenicity 6 Protein 4
  • Suppression Of Tumorigenicity 6 2
  • R2 Leukocyte Antigen 2
  • GR15 3
  • 4F9 3
  • C33 3
  • R2 3

External Ids for CD82 Gene

Previous HGNC Symbols for CD82 Gene

  • ST6
  • KAI1

Previous GeneCards Identifiers for CD82 Gene

  • GC11P044544
  • GC11P044296

Summaries for CD82 Gene

Entrez Gene Summary for CD82 Gene

  • This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD82 Gene

CD82 (CD82 Molecule) is a Protein Coding gene. Diseases associated with CD82 include facial paralysis and prostate cancer. Among its related pathways are Integrated Pancreatic Cancer Pathway and Direct p53 effectors. An important paralog of this gene is TSPAN9.

UniProtKB/Swiss-Prot for CD82 Gene

  • Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Wiki entry for CD82 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD82 Gene

Genomics for CD82 Gene

Regulatory Elements for CD82 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD82 Gene

44,564,427 bp from pter
44,620,363 bp from pter
55,937 bases
Plus strand

Genomic View for CD82 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD82 Gene

Proteins for CD82 Gene

  • Protein details for CD82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD82 antigen
    Protein Accession:
    Secondary Accessions:
    • D3DQN6
    • E9PC70
    • Q7Z2D4
    • Q7Z5N2

    Protein attributes for CD82 Gene

    267 amino acids
    Molecular mass:
    29626 Da
    Quaternary structure:
    • Interacts directly with IGSF8.

    Alternative splice isoforms for CD82 Gene


neXtProt entry for CD82 Gene

Proteomics data for CD82 Gene at MOPED

Post-translational modifications for CD82 Gene

  • Ubiquitination at Lys190
  • Glycosylation at Asn129, Asn157, and Asn198
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD82 (CD82)

No data available for DME Specific Peptides for CD82 Gene

Domains for CD82 Gene

Gene Families for CD82 Gene

Suggested Antigen Peptide Sequences for CD82 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD82: view

Function for CD82 Gene

Molecular function for CD82 Gene

UniProtKB/Swiss-Prot Function:
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Ontology (GO) - Molecular Function for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15205336
genes like me logo Genes that share ontologies with CD82: view

Phenotypes for CD82 Gene

genes like me logo Genes that share phenotypes with CD82: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD82

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD82 Gene

Localization for CD82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD82 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CD82 Gene COMPARTMENTS Subcellular localization image for CD82 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
endosome 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 7754374
GO:0005887 integral component of plasma membrane TAS 1842498
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CD82: view

Pathways for CD82 Gene

genes like me logo Genes that share pathways with CD82: view

Pathways by source for CD82 Gene

1 Cell Signaling Technology pathway for CD82 Gene
2 BioSystems pathways for CD82 Gene
1 KEGG pathway for CD82 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CD82 Gene


Drugs for CD82 Gene

(5) Novoseek inferred chemical compound relationships for CD82 Gene

Compound -log(P) Hits PubMed IDs
at-61 83.6 1
digitonin 29.5 1
tyrosine 16 6
paraffin 0 1
cholesterol 0 2
genes like me logo Genes that share compounds with CD82: view

Transcripts for CD82 Gene

Unigene Clusters for CD82 Gene

CD82 molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD82

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD82 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP7: - -

Relevant External Links for CD82 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD82 Gene

mRNA expression in normal human tissues for CD82 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD82 Gene

This gene is overexpressed in Whole Blood (7.2).

Protein differential expression in normal tissues for CD82 Gene

This gene is overexpressed in Nasal epithelium (54.6) and Amniocyte (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD82 Gene

SOURCE GeneReport for Unigene cluster for CD82 Gene Hs.527778

mRNA Expression by UniProt/SwissProt for CD82 Gene

Tissue specificity: Lymphoid specific
genes like me logo Genes that share expressions with CD82: view

Primer Products

In Situ Assay Products

No data available for Expression partners for CD82 Gene

Orthologs for CD82 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD82 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100335281 35
  • 84.77 (n)
  • 77.15 (a)
CD82 36
  • 77 (a)
(Canis familiaris)
Mammalia CD82 35
  • 86.64 (n)
  • 82.02 (a)
CD82 36
  • 75 (a)
(Mus musculus)
Mammalia Cd82 35
  • 79.45 (n)
  • 76.69 (a)
Cd82 16
Cd82 36
  • 77 (a)
(Pan troglodytes)
Mammalia CD82 35
  • 99.5 (n)
  • 99.63 (a)
CD82 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cd82 35
  • 78.57 (n)
  • 76.69 (a)
(Monodelphis domestica)
Mammalia CD82 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia CD82 36
  • 61 (a)
(Gallus gallus)
Aves CD82 35
  • 64.36 (n)
  • 61.54 (a)
CD82 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
-- 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd82 35
  • 65.6 (n)
  • 63.2 (a)
MGC76214 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24083 35
(Danio rerio)
Actinopterygii cd82b 35
  • 63.24 (n)
  • 57.71 (a)
cd82a 36
  • 53 (a)
cd82b 36
  • 55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004861 35
  • 44.54 (n)
  • 31.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp66E 35
  • 49.17 (n)
  • 30.32 (a)
Tsp66E 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea tsp-8 35
  • 44.54 (n)
  • 32.38 (a)
tsp-11 36
  • 23 (a)
tsp-13 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
-- 36
  • 16 (a)
Species with no ortholog for CD82:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD82 Gene

Gene Tree for CD82 (if available)
Gene Tree for CD82 (if available)

Paralogs for CD82 Gene

Paralogs for CD82 Gene

genes like me logo Genes that share paralogs with CD82: view

Variants for CD82 Gene

Sequence variations from dbSNP and Humsavar for CD82 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7952560 -- 44,590,567(+) gattg(C/T)gcctc intron-variant
rs7952181 -- 44,599,511(+) CACTT(A/G)GCACC intron-variant
rs7947592 -- 44,580,891(+) CCTGT(C/G)TCTAC intron-variant
rs7946989 -- 44,580,406(+) ACTGA(G/T)GCTCG intron-variant
rs7946090 -- 44,592,908(+) CGCTT(A/G)TGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD82 Gene

Variant ID Type Subtype PubMed ID
nsv897306 CNV Gain 21882294
nsv897308 CNV Loss 21882294
nsv525321 CNV Gain 19592680
nsv522766 CNV Loss 19592680
nsv897309 CNV Gain 21882294

Relevant External Links for CD82 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD82 Gene

Disorders for CD82 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CD82 Gene in MalaCards »

(4) Diseases for CD82 Gene

(1) OMIM Diseases for CD82 Gene (600623)

(3) University of Copenhagen DISEASES for CD82 Gene

(43) Novoseek inferred disease relationships for CD82 Gene

Disease -log(P) Hits PubMed IDs
metastasis 74.8 222
prostate cancer 59 62
cancer 52.8 70
pancreatic cancer 51.3 34
allelic loss 48.5 9

Relevant External Links for CD82

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD82: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD82 Gene

Publications for CD82 Gene

  1. Genomic organization of the human KAI1 metastasis-suppressor gene. (PMID: 9126478) Dong J.T. … Isaacs J.T. (Genomics 1997) 3 4 23
  2. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. (PMID: 7754374) Dong J.T. … Barrett J.C. (Science 1995) 3 4 23
  3. C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. (PMID: 1401919) Imai T. … Yoshie O. (J. Immunol. 1992) 3 4 23
  4. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. (PMID: 15829968) Kim J.H. … Baek S.H. (Nature 2005) 3 23
  5. KAI1 metastasis suppressor protein is down-regulated during the progression of human endometrial cancer. (PMID: 12684410) Liu F.S. … Chiou L.C. (Clin. Cancer Res. 2003) 3 23

Products for CD82 Gene

  • Addgene plasmids for CD82

Sources for CD82 Gene

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