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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD82 Gene

protein-coding   GIFtS: 57
GCID: GC11P044586

CD82 molecule

(Previous names: kangai 1 (suppression of tumorigenicity 6, prostate; CD82...)
(Previous symbols: ST6, KAI1)
 Explore 59 diseases affiliated with
CD82 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD82    

Aliases
for CD82 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD82 Molecule1 2     Metastasis Suppressor Kangai-12 3
KAI11 2 3 5     C33 Antigen2 3
ST61 2 3 5     4F92
IA41 2 3     C332
TSPAN271 2 3     GR152
CD82 Antigen1 2 3     Tetraspanin-273
SAR22 3 5     Tspan-273
R21 2     Tetraspanin-273
Kangai 1 (Suppression Of Tumorigenicity 6, Prostate; CD82 Antigen (R2 Leukocyte
Antigen, Antigen Detected By Monoclonal And Antibody IA4))1 2
     Tspan-273
Inducible Membrane Protein R22 3     Suppressor Of Tumorigenicity 6 Protein3

External Ids:    HGNC: 62101   Entrez Gene: 37322   Ensembl: ENSG000000851177   OMIM: 6006235   UniProtKB: P277013   

Export aliases for CD82 gene to outside databases

Previous GC identifers: GC11P044544 GC11P044296


Summaries
for CD82 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD82:
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily.
Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated
by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated,
and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two
alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD82_HUMAN, P27701
Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

Gene Wiki entry for CD82


Genomic Views
for CD82 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD82 gene promoter:
         AP-1   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD82 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD82

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD82


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

CD82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD82 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P044586:  view genomic region     (about GC identifiers)

Start:
 44,585,977 bp from pter      End:
 44,641,913 bp from pter
Size:
 55,937 bases      Orientation:
 plus strand

Proteins
for CD82 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD82_HUMAN, P27701 (See protein sequence)
Recommended Name: CD82 antigen  
Size: 267 amino acids; 29626 Da
Subunit: Interacts directly with IGSF8
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: D3DQN6 E9PC70 Q7Z2D4 Q7Z5N2
Alternative splicing: 2 isoforms:  P27701-1   P27701-2   

Explore the universe of human proteins at neXtProt for CD82: NX_P27701

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P27701

    • CD82 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020015.1  NP_002222.1  

    ENSEMBL proteins: 
     ENSP00000435682   ENSP00000227155   ENSP00000339686   ENSP00000431767   ENSP00000435661  
     ENSP00000433151   ENSP00000436403   ENSP00000433804   ENSP00000433788   ENSP00000433036  

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    OriGene Protein Over-expression Lysate: CD82
    OriGene Custom Protein Services for CD82 
    GenScript Custom Purified and Recombinant Proteins Services for CD82
    Novus Biologicals CD82 Proteins
    Novus Biologicals CD82 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD82

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS7754374
    GO:0005887integral to plasma membrane TAS1842498
    GO:0016021integral to membrane ----


    CD82 for ontologies           About GeneDecksing



    CD82 Antibody Products: 
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    Uscn ELISAs and CLIAs for CD82

    Protein Domains /
    Families
    for CD82 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD82 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P27701

    ProtoNet protein and cluster: P27701

    1 Blocks protein family: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: CD82_HUMAN, P27701
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Function
    for CD82 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD82_HUMAN, P27701
    Function: Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD82:
    hsa-miR-338-5p hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmid: CD82 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD82 (see all 7)
    OriGene shRNA RFP: CD82
    OriGene siRNA: CD82
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD82

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD82

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD82 (see all 5)
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    Cell Line
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    Search LifeMap BioReagents cell lines for CD82

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15205336


    CD82 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CD82:
     Increased cilium length after   Synthetic lethal with Ras 


    Pathways & Interactions
    for CD82 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99
    2Lymphocyte Signaling
    		Lymphocyte Signaling1.00
    3Direct p53 effectors
    		Direct p53 effectors1.00
    4p53 signaling pathway
    		p53 signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CD82
        Lymphocyte Signaling

    3 BioSystems Pathways for CD82 
        Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Direct p53 effectors


    1         Kegg Pathway  (Kegg details for CD82):
        p53 signaling pathway


    CD82 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD82

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for CD82 (P277011, 3 ENSP000002271554) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VANGL1Q8TAA91, 3, ENSP000003108004EBI-682379,EBI-682393 I2D: score=2 STRING: ENSP00000310800
    CD19P153913, ENSP000003134194I2D: score=2 STRING: ENSP00000313419
    ERBB2P046263, ENSP000002695714I2D: score=2 STRING: ENSP00000269571
    HLA-DRAP019033, ENSP000003787864I2D: score=2 STRING: ENSP00000378786
    IGSF8Q969P03, ENSP000003166644I2D: score=2 STRING: ENSP00000316664
    About this table

    Drugs & Compounds
    for CD82 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD82 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD82
    5 Novoseek chemical compound relationships for CD82 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    at-61 83.6 1 9041184 (1)
    digitonin 29.5 1 12938224 (1)
    tyrosine 16 6 17215249 (4), 18395972 (1), 15454569 (1)
    cholesterol 0 4 12938224 (1), 15454569 (1)
    paraffin 0 1 15783050 (1)

    Search CenterWatch for drugs/clinical trials and news about CD82 

    Transcripts
    for CD82 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD82 gene (2 alternative transcripts): 
    NM_001024844.1  NM_002231.3  

    Unigene Cluster for CD82:

    CD82 molecule
    Hs.527778  [show with all ESTs]
    Unigene Representative Sequence: NM_002231
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526958 ENST00000227155(uc001myc.3 uc001myd.3) ENST00000342935
    ENST00000532544 ENST00000529277 ENST00000525210 ENST00000525898 ENST00000527737
    ENST00000524704 ENST00000525813 ENST00000529853 ENST00000530601 ENST00000530931
    ENST00000524750

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD82
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD82:
    hsa-miR-338-5p hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmid: CD82 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD82 (see all 7)
    OriGene shRNA RFP: CD82
    OriGene siRNA: CD82
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD82
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD82 (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 2): CD82 (NM_002231)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD82 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD82
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD82

    Additional cDNA sequence: 

    AK225410.1 AK225708.1 AK312677.1 AY303776.1 BC000726.2 BC001821.2 BT019761.1 BT019762.1 
    CR407650.1 CR542255.1 S48196.1 U20770.1 

    19 DOTS entries:

    DT.100793427  DT.313063  DT.97844941  DT.100793432  DT.120712758  DT.120712722  DT.92442010  DT.100793426 
    DT.120712724  DT.91742256  DT.100793430  DT.120712748  DT.120712751  DT.40261002  DT.95076548  DT.95076555 
    DT.120712720  DT.120753710  DT.95315953 

    24/268 AceView cDNA sequences (see all 268):

    BU185132 CR609000 BU785750 AW168332 CR593263 BE871165 BG759651 BM473622 
    BE349302 CR615871 BI753805 BE293674 BU785446 BG654786 BP366951 AU119042 
    CR606617 BE205860 BM914425 AU077255 AI354379 BU196310 BM353004 BQ688811 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CD82 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                    -     -                 -                                             
    SP2:                    -     -                 -     -                                       
    SP3:                          -                 -                                             
    SP4:                                            -                                             
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CD82

    Expression
    for CD82 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD82 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAAGGTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CD82 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD82

    SOURCE GeneReport for Unigene cluster: Hs.527778

    UniProtKB/Swiss-Prot: CD82_HUMAN, P27701
    Tissue specificity: Lymphoid specific

        SABiosciences Expression via Pathway-Focused PCR Array including CD82: 
              Tumor Metastasis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD82

    Orthologs
    for CD82 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CD82 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CD821 CD82 molecule 64.36(n)
    61.54(a)    		   423172  NM_001008470.1  NP_001008470.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CD826
    --
    		 --
    		 63(a)
    40(a)
    		 1 ↔ many
    1 ↔ many
    		 1(46122410-46149569)
    GL343557.1(328922-329948)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.240832 Xenopus laevis transcribed sequence with weak similarity more 76.08(n)    BJ061882.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC054586.12   -- 71.75(n)    BC054586.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tsp66E1 Tetraspanin 66E 50.35(n)
    32.34(a)    		   39017  NM_168298.1  NP_729423.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea tsp-81 Protein TSP-8 41.73(n)
    30(a)    		   181567  NM_078044.4  NP_510445.1 


    ENSEMBL Gene Tree for CD82 (if available)
    TreeFam Gene Tree for CD82 (if available) 

    Paralogs
    for CD82 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD82 gene
    CD1512  TSPAN12  CD372  TSPAN62  TSPAN92  TSPAN32  CD632  CD532  
    TSPAN182  TSPAN72  TSPAN42  TSPAN112  ENSG000002503492  TSPAN82  
    18/23 SIMAP similar genes for CD82 using alignment to 10 protein entries:     CD82_HUMAN (see all proteins) (see all similar genes):
    TSPAN18    BTCC-1    CD81    CD37    CD9    TSPAN19
    TSPAN4    CD53    TSPAN2    CD151    TSPAN11    TSPAN5
    TSPAN1    TSPAN9    TSPAN17    TM4SF2    TSPAN7    TM4SF9

    CD82 for paralogs           About GeneDecksing



    Genomic Variants
    for CD82 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1026 NCBI SNPs in CD82 are shown (see all 1026)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs122241741,2
    		C,H,--44294433(+) TCTGCC/TATACA 2 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs794033001,2
    		F,--44294730(+) GAATGC/TTATGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs124195391,2
    		C,H--44294958(+) GCTACT/CTAGGT 2 -- us2k11Minor allele frequency- C:0.00NA 2
    rs774616411,2
    		F,--44295374(+) GAGGGC/TAGAGG 2 -- us2k11Minor allele frequency- T:0.03EA 120
    rs79331601,2
    		C,F,--44295772(+) AGGGCT/AAGAAC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs753336411,2
    		F,--44296269(+) GACTCC/TGTAGC 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs115410481,2
    		C--44296502(+) AGTCCG/AACGCC 2 -- ut512Minor allele frequency- A:0.00NA 4
    rs714900711,2
    		C,F,--44296646(+) CTGCGG/ATCCGG 2 -- int14Minor allele frequency- A:0.09NA 126
    rs761669121,2
    		--44297538(+) AAGGTA/GCCAGG 2 -- int10--------
    rs43650361,2
    		C,F,A,--44297571(-) AGCAGC/TTGTCA 2 -- int17Minor allele frequency- T:0.28NA WA CSA 248

    HapMap Linkage Disequilibrium report for CD82 (44585977 - 44641913 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CD82: --

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    Disorders / Diseases
    for CD82 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD82 for disorders           About GeneDecksing

    OMIM gene information: 600623   
    OMIM disorders: 176807  
    20/59 diseases for CD82 (see all 59):    About MalaCards
    prostatitis    prostate cancer    human t-cell leukemia virus type 1    squamous cell carcinoma
    facial paralysis    severe acute respiratory syndrome    laryngeal squamous cell carcinoma    oral squamous cell carcinoma
    carcinoma    renal oncocytoma    esophageal squamous cell carcinoma    cervical squamous cell carcinoma
    transitional cell carcinoma    newcastle disease    bladder carcinoma    cervicitis
    intrahepatic cholangiocarcinoma    epithelial ovarian cancer    cervical cancer    gallbladder adenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for CD82:
    Facial paralysis     Prostate cancer     Carcinoma

    10/43 Novoseek disease relationships for CD82 gene (see all 43)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 74.8 303 18028322 (6), 12753720 (6), 8813131 (6), 17283532 (6) (see all 99)
    prostate cancer 59 80 10440748 (7), 8813131 (5), 9254900 (5), 11572762 (4) (see all 36)
    cancer 52.8 100 9671393 (4), 11331321 (3), 9699525 (3), 10440748 (2) (see all 52)
    pancreatic cancer 51.3 39 15944768 (5), 18286698 (5), 19489224 (4), 8895737 (4) (see all 12)
    allelic loss 48.5 12 8813131 (5), 11895916 (1), 9126478 (1), 9254900 (1) (see all 5)
    tumors 47.7 161 12684410 (5), 10568187 (5), 10873402 (5), 9736732 (5) (see all 62)
    primary tumor 44.6 23 11895916 (2), 10582691 (2), 17308076 (2), 15592684 (1) (see all 11)
    bladder cancer 40.4 27 17982617 (4), 10767717 (3), 10840154 (3), 9815782 (3) (see all 8)
    carcinoma 35.7 35 15259074 (6), 18575327 (3), 12747469 (2), 19024519 (2) (see all 16)
    metastatic cancer 35.7 4 16271511 (1), 11715465 (1)

    Human Genome Epidemiology (HuGE) Navigator: CD82 (1 document)

    Export disorders for CD82 gene to outside databases

    Publications
    for CD82 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD82 gene, integrated from 9 sources (see all 277):
    (articles sorted by number of sources associating them with CD82)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human KAI1 metastasis-suppressor gene. (PubMed id 9126478)1, 2, 9 Dong J.T.... Isaacs J.T. (1997)
    2. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. (PubMed id 7754374)1, 2, 9 Dong J.T. and Barrett J.C. (1995)
    3. C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63. (PubMed id 1401919)1, 2, 9 Imai T.... Yoshie O. (1992)
    4. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. (PubMed id 12750295)1, 2 Zhang X.A.... Liu L. (2003)
    5. A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23. (PubMed id 1842498)1, 2 Gaugitsch H.W.... Baumruker T. (1991)
    6. High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis. (PubMed id 11895916)1, 9 Uzawa K....Tanzawa H. (2002)
    7. Loss of KAI1 expression in the progression of colorectal cancer. (PubMed id 10582691)1, 9 Lombardi D.P....Barrett J.C. (1999)
    8. CD82, and CD63 in thyroid cancer. (PubMed id 15375577)1, 9 Chen Z....Hoang-Vu C. (2004)
    9. [Role of tumor metastasis suppressor gene KAI1 in development of colorectal cancer] (PubMed id 12753720)1, 9 Yang J....Liu L.M. (2003)
    10. KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer. (PubMed id 18712725)1, 9 Christgen M....Lehmann U. (2008)

    External Searches for CD82 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing CD82 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3732 HGNC: 6210 AceView: KAI1 Ensembl:ENSG00000085117 euGenes: HUgn3732
    ECgene: CD82 Kegg: 3732 H-InvDB: CD82

    Other Databases showing CD82 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD82 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD82 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD82 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CD82 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD82 gene:
    Search GeneIP for patents involving CD82

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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