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CD81 Gene

protein-coding GIFtS: 65

GC11P002355

CD81 molecule
(Previous name: CD81 antigen (target of antiproliferative antibody 1) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TAPA1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
S5.7 ^²
TAPA-1 ^¹
TAPA1 ^², ³, ⁵
TSPAN28 ^¹, ², ³
Tetraspanin-28 ^³
Tspan-28 ^³

Descriptions
26 kDa cell surface protein TAPA-1 ^², ³
CD81 antigen ^², ³
CD81 antigen (target of antiproliferative antibody 1) ^¹, ²
CD81 molecule ^²
Target of the antiproliferative antibody 1 ^³
target of antiproliferative antibody 1 ^²

External Ids
HGNC: 1701¹
Entrez Gene: 975²
UniProtKB: P60033³
Ensembl: ENSG00000110651⁷

Search outside databases for aliases for CD81 gene

Previous GC identifers: GC11P002460 GC11P002599 GC11P002356 GC11P002363

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CD81:

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the

tetraspanin family. Most of these members are cell-surface proteins that are characterized by the

presence of four hydrophobic domains. The proteins mediate signal transduction events that play a

role in the regulation of cell development, activation, growth and motility. This encoded protein

is a cell surface glycoprotein that is known to complex with integrins. This protein appears to

promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal

transduction. This gene is localized in the tumor-suppressor gene region and thus it is a

candidate gene for malignancies. [provided by RefSeq]

UniProtKB/Swiss-Prot: CD81_HUMAN, P60033

Function: May play an important role in the regulation of lymphoma cell growth. Interacts with a

16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the

viral receptor for HCV

Gene Wiki entry for CD81

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CD81 gene

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11pter-p11.2

CD81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P002355: (about GC identifiers)

Start:	2,355,123 bp from pter
End:	2,375,225 bp from pter
Size:	20,103 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CD81_HUMAN, P60033 (See protein sequence)

Recommended Name: CD81 antigen

Size: 236 amino acids; 25809 Da

Subunit: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2

glycoproteins heterodimer. Interacts directly with IGSF8

Subcellular location: Membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1G8Q (3D)

1IV5 (3D)

2AVZ (3D)

Secondary accessions: P18582 Q5U0J6

Post-translational modifications:

Not glycosylated (Probable)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004347.1

ENSEMBL proteins:

ENSP00000263645 ENSP00000370424

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TAPA1)
	Human Recombinant Proteins from Abnova (CD81)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	IDA	14676841
GO:0016020	membrane	IEA	--

About this table

Antibodies for CD81:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CD81
	Sigma-Aldrich Antibodies for CD81
	R&D Systems Antibodies for CD81
	Antibodies from Abcam (TAPA1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CD81)
	Novus Biologicals Antibodies for CD81

Assays for CD81:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P60033

ProtoNet protein and cluster: P60033

UniProtKB/Swiss-Prot: CD81_HUMAN, P60033

Similarity: Belongs to the tetraspanin (TM4SF) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD81)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD81)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004356

Applied Biosystems Silencer® siRNAs for CD81

Sigma-Aldrich siRNA and siRNA Panels for CD81

Sigma-Aldrich shRNA Panels and shRNA for CD81

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004356
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004356
untagged cDNA clone in CMV expression vector: NM_004356

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004356

UniProtKB/Swiss-Prot: CD81_HUMAN, P60033

Function: May play an important role in the regulation of lymphoma cell growth. Interacts with a

16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the

viral receptor for HCV

Genatlas biochemistry entry for CD81:

integral membrane protein (26kDa),associated with CD19,B cell surface molecule,expressed on many

cell types,target of an antiproliferative antibody

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cd81):

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14676841

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CD81

5/44 Interacting proteins for CD81 (P60033² ENSP00000370424³) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DLG5	Q8TDM6²	MINT-63912
INO80B	Q9C086²	MINT-65400
CD19	ENSP00000313419³	STRING (score=.999)
CR2	ENSP00000356024³	STRING (score=.998)
PTGFRN	ENSP00000358485³	STRING (score=.991)

About this table

5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IDA	14676841
GO:0006661	phosphatidylinositol biosynthetic process	IDA	14676841
GO:0006952	defense response	TAS	1695320
GO:0008104	protein localization	IDA	14676841
GO:0008284	positive regulation of cell proliferation	IDA	14676841

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CD81
7 Novoseek chemical compound relationships for CD81 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
digitonin	42.69	6	9804823 (3), 10229664 (2), 12938224 (1)
ganglioside	24.29	3	15248289 (1), 15710618 (1)
tyrosine	3.75	2	12645944 (1), 8683154 (1)
calcium	2.76	1	12645944 (1)
cholesterol	0.00	4	15004227 (1), 12938224 (1)
lipid	0.00	3	12645944 (1), 11113129 (1)
phosphatidylinositol	0.00	3	9006891 (2), 11113129 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD81)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD81)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004356

Sigma-Aldrich siRNA and siRNA Panels for CD81

Sigma-Aldrich shRNA Panels and shRNA for CD81

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004356

REFSEQ mRNAs for CD81 gene:

NM_004356.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004356

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004356
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004356
                                 untagged cDNA clone in CMV expression vector: NM_004356

Additional cDNA sequence:

AB209380.1 BC002978.1 BC093047.1 BT019507.1 BT019508.1 CR593787.1 CR595315.1 CR597052.1

CR597764.1 CR597813.1 CR598183.1 CR598692.1 CR599310.1 CR601869.1 CR604204.1 CR604277.1

CR604916.1 CR605197.1 CR608902.1 CR616730.1 CR617842.1 CR618893.1 CR621738.1 CR622188.1

CR625241.1 M33680.1

24/29 DOTS entries (see all 29 ):

DT.92453568 DT.100885968 DT.100040647 DT.451059 DT.97864485 DT.95157455 DT.451056 DT.91978911

DT.91689119 DT.120734561 DT.120734601 DT.100769546 DT.100885965 DT.95157374 DT.100885949 DT.100885952

DT.101985222 DT.120734607 DT.121632864 DT.97856641 DT.100885951 DT.100885953 DT.120734553 DT.120734571

24/858 AceView cDNA sequences (see all 858 ):

BU187454 BE392104 BQ688058 CR604916 AA460973 CF121199 BM823137 CA434584

BM851827 BU848699 CD367805 BM981166 BI759896 BU625142 BI013033 CA418965

BQ691409 BQ883552 AA335633 CA430012 CR617842 BU751874 CR593787 CR622188

highest scoring ESTs for CD81:

AI972078 M33680 AA027242 AA037705 AA055991 AA099591 AA132176 AA216044 AA247187 AA251438

Unigene Cluster for CD81:

CD81 molecule

Hs.54457 [show with all ESTs]

Unigene Representative Sequence: AB209380

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CD81 (see all 12 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	^	15	^	16a	·	16b
SP1:							-		-		-		-		-		-		-				-		-				-				-
SP2:													-		-		-		-				-		-				-				-
SP3:											-		-		-		-		-				-		-				-				-
SP4:																							-		-				-				-
SP5:															-		-		-				-		-				-				-

About this scheme

ECgene alternative splicing isoforms for CD81

2 Ensembl transcripts including schematic representations:

ENST00000263645 ENST00000381036

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CD81 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CD81

¹ / ² / ³

4 probe-sets matching CD81 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35282_r_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.93	M33680	1.00	1.00	1.00	1
89843_at²^{, 3}	U95-D	1	0.56	1.00	0.96	1.07	AI972078	1.00	1.00	1.00	1
200675_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004356	0.60	1.00	0.82	1
200675_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.54457
Expression variation in blood from EXPOLDB for CD81
UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
Tissue specificity: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CD81 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CD81¹	--	CD81 molecule	91.43(n) 96.73(a)	611606 XM_849288.1 XP_854381.1
chimpanzee (Pan troglodytes)	CD81¹	--	CD81 molecule	99.29(n) 100(a)	449635 NM_001009023.1 NP_001009023.1
rat (Rattus norvegicus)	Cd81¹	--	Cd81 molecule	87.01(n) 93.22(a)	25621 NM_013087.1 NP_037219.1
mouse (Mus musculus)	Cd81^{1, 5}	7 (69.30 cM)⁵	CD81 antigen^{1, 5}	86.72(n)¹ 91.95(a)¹	12520¹ NM_133655.1¹ NP_598416.1¹ AJ251835⁵ AK136370⁵ (see all 24)
chicken (Gallus gallus)	CD81¹	--	CD81 molecule	78.12(n) 80.37(a)	374256 NM_001030339.1 NP_001025510.1

About this table Species with no ortholog for CD81

ENSEMBL Gene Tree for CD81

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CD81 gene

TSPAN2² CD9²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/198 NCBI SNPs in CD81 are shown (see all 198 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 123)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs708155^1,2	A,C,F,H	2353571(+)	`CTACCG/ACCCCC`	1	--	ng5¹		12		EA MN EU WA CSAM	2466
	rs708154^1,2	A,C,F,H	2353242(+)	`AACCCC/TGTGAC`	1	--	ng5¹		6		EU WA EA	638
--	rs7124991^1,2	A,C,F,H	2375609(+)	`aataaT/Ctggtt`	1	--	ng3¹		3		EU EA	300
	rs11022610^1,2	A,C,F,H	2375472(+)	`tacttA/Gattgt`	1	--	ng3¹		4		EU EA WA	388
--	rs7106086^1,2	A,C,F,H	2375679(+)	`gagacC/Aaagat`	1	--	ng3¹		4		EU EA WA	390
	rs1049390^1,2	A,C,F,H	2374913(+)	`AGGGCA/GGGGGT`	1	--	ut3¹ ese³		10		MN EU EA WA CSAM	994
	rs11022515^1,2	C,F,H	2353921(+)	`ccaatG/Atgagc`	1	--	ng5¹		4		EU EA WA	418
--	rs1049549^1,2	A,C,F	2375006(+)	`CCAACT/CTGGGG`	1	--	ut3¹		6		MN CSAM EA	584
	rs7105227^1,2	A,H	2375657(+)	`atctgG/Agttaa`	1	--	ng3¹		4		EU EA WA	408
	rs10831946^1,2	A,C	2375280(+)	`GACATC/GGGTGG`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CD81 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 186845

10/15 Novoseek disease relationships for CD81 gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis c	78.02	46	12645944 (2), 14722300 (2), 11024134 (2), 11134943 (2) (see all 36)
hepatitis c chronic	57.69	9	11130883 (2), 16735696 (2), 16623441 (1), 11391542 (1) (see all 7)
virus infection	40.74	11	11985527 (2), 14722300 (1), 11602742 (1), 17194487 (1) (see all 9)
hepatocellular carcinoma	31.59	6	11115611 (2), 12210407 (1), 11130883 (1), 16819966 (1)
lymphoproliferative disorders	24.01	2	17177963 (1), 12558906 (1)
immunodeficiency	12.29	2	17177963 (1), 15767432 (1)
metastasis	8.92	8	15698400 (2), 11115611 (2), 18466772 (1), 9597125 (1)
hepatitis	3.59	1	11130883 (1)
necrosis	0.00	2	8668914 (1), 18805782 (1)
cancer	0.00	4	11115611 (2), 9671393 (1), 19211836 (1)

About this table

Genetic Association Database: CD81
Human Genome Epidemiology Navigator: CD81 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/238 PubMed articles for CD81 gene (see all 238 ):

TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. (PubMed id 1695320)^{1, 3, 4} Oren R.... Levy S. (1990)
Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. (PubMed id 12437138)^{1, 3, 4} Kitadokoro K.... Bolognesi M. (2002)
Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. (PubMed id 12913001)^{1, 3, 4} Bartosch B.... Cosset F.-L. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
CD81-dependent binding of hepatitis C virus E1E2 heterodimers. (PubMed id 12970454)^{3, 4} Cocquerel L.... Levy S. (2003)
Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection. (PubMed id 12209363)^{3, 6} Hennig B.J....Hill A.V. (2002)
CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs. (PubMed id 11226150)^{3, 4} Kitadokoro K.... Bolognesi M. (2001)
EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PubMed id 11504738)^{3, 4} Stipp C.S.... Hemler M.E. (2001)
Structure and membrane topology of TAPA-1. (PubMed id 1860863)^{3, 4} Levy S.... Takahashi S. (1991)
Genomic organization and chromosomal localization of the TAPA-1 gene. (PubMed id 1650385)^{2, 3} Andria M.L....Levy S. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 975	HGNC: 1701	AceView: CD81	Ensembl:ENSG00000110651	euGenes: HUgn975
ECgene: CD81	H-InvDB: CD81

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CD81	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CD81
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CD81:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CD81-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CD81		Antibodies for CD81
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CD81		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CD81)
	Antibodies (CD81)
	Chimera RNAi (CD81)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (TAPA1)

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Search Tocris compounds for CD81

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Antibodies for CD81

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CD81 Gene at Home site.
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CD81 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CD81

Summaries
for CD81

Genomic Location
for CD81

Proteins
for CD81

Protein Domains/
Families
for CD81

Gene Function
for CD81

Pathways & Interactions
for CD81

Drugs & Compounds
for CD81

Transcripts
for CD81

Expression
for CD81

Orthologs
for CD81

Paralogs
for CD81

SNPs/Variants
for CD81

Disorders & Mutations
for CD81

Medical News
for CD81

Publications
for CD81

Search for CD81

Genome Databases showing CD81

Other Databases showing CD81

Specialized Databases showing CD81

Licensable Technologies
for CD81

Services
for CD81

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CD81 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CD81

Summariesfor CD81

Genomic Locationfor CD81

Proteinsfor CD81

Protein Domains/Familiesfor CD81

Gene Functionfor CD81

Pathways & Interactionsfor CD81

Drugs & Compoundsfor CD81

Transcriptsfor CD81

Expression for CD81

Orthologsfor CD81

Paralogsfor CD81

SNPs/Variantsfor CD81

Disorders & Mutationsfor CD81

Medical Newsfor CD81

Publicationsfor CD81

Search for CD81

Genome Databases showing CD81

Other Databases showing CD81

Specialized Databases showing CD81

Licensable Technologiesfor CD81

Servicesfor CD81

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CD81

Summaries
for CD81

Genomic Location
for CD81

Proteins
for CD81

Protein Domains/
Families
for CD81

Gene Function
for CD81

Pathways & Interactions
for CD81

Drugs & Compounds
for CD81

Transcripts
for CD81

Expression
for CD81

Orthologs
for CD81

Paralogs
for CD81

SNPs/Variants
for CD81

Disorders & Mutations
for CD81

Medical News
for CD81

Publications
for CD81

Licensable Technologies
for CD81

Services
for CD81