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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD81 Gene

protein-coding   GIFtS: 66
GCID: GC11P002397

CD81 molecule

(Previous name: CD81 antigen (target of antiproliferative antibody 1) )
(Previous symbol: TAPA1)
 Explore 29 diseases affiliated with
CD81 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD81    

Aliases
for CD81 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD81 Molecule1 2     TAPA-11
TAPA11 2 3 5     S5.72
TSPAN281 2 3     Tetraspanin-283
CD81 Antigen (Target Of Antiproliferative Antibody 1)1 2     Tspan-283
26 KDa Cell Surface Protein TAPA-12 3     Tetraspanin-283
CD81 Antigen2 3     Tspan-283
CVID62 5     Target Of The Antiproliferative Antibody 13

External Ids:    HGNC: 17011   Entrez Gene: 9752   Ensembl: ENSG000001106517   OMIM: 1868455   UniProtKB: P600333   

Export aliases for CD81 gene to outside databases

Previous GC identifers: GC11P002460 GC11P002599 GC11P002356 GC11P002363 GC11P002355 GC11P002188


Summaries
for CD81 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD81:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.
Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.
The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,
growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This
protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal
transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for
malignancies. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
Function: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein
to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV

Gene Wiki entry for CD81


Genomic Views
for CD81 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD81 gene promoter:
         STAT1   MAZR   Pax-5   Brachyury   STAT1beta   Lmo2   STAT1alpha   Gfi-1   ZIC2/Zic2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD81 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD81

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD81


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11pter-p11.2

CD81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD81 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P002397:  view genomic region     (about GC identifiers)

Start:
 2,397,407 bp from pter      End:
 2,418,649 bp from pter
Size:
 21,243 bases      Orientation:
 plus strand

Proteins
for CD81 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD81_HUMAN, P60033 (See protein sequence)
Recommended Name: CD81 antigen  
Size: 236 amino acids; 25809 Da
Subunit: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins
heterodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM2 and IFITM3 (By
similarity). Interacts with IFITM1
Subcellular location: Membrane; Multi-pass membrane protein
3 PDB 3D structures from and Proteopedia for CD81:
1G8Q (3D)        1IV5 (3D)        2AVZ (3D)    
Secondary accessions: P18582 Q5U0J6

Explore the universe of human proteins at neXtProt for CD81: NX_P60033

Post-translational modifications:

  • Not glycosylated (Probable)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P60033

    • CD81 Protein expression data from MOPED and PaxDb:    About this image 
    CD81 Protein Expression
    REFSEQ proteins: NP_004347.1  
    ENSEMBL proteins: 
     ENSP00000433178   ENSP00000432723   ENSP00000263645   ENSP00000435633   ENSP00000437242  
     ENSP00000433767   ENSP00000433904   ENSP00000432497   ENSP00000370424   ENSP00000432249  
     ENSP00000431780   ENSP00000432033  
    Reactome Protein details: P60033
    Human Recombinant Protein Products for CD81: 
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    OriGene Purified Protein: CD81
    OriGene Protein Over-expression Lysate: CD81
    OriGene Custom Protein Services for CD81 
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    Novus Biologicals CD81 Proteins
    Novus Biologicals CD81 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD81

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA14676841
    GO:0016021integral to membrane ----
    GO:0016324apical plasma membrane ----

    CD81 for ontologies           About GeneDecksing



    CD81 Antibody Products: 
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    Novus Biologicals CD81 Antibodies
    Abcam antibodies for CD81 
    Uscn Antibodies for CD81
    ThermoFisher Antibodies for CD81

    Assay Products for CD81: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD81
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CD81

    Protein Domains /
    Families
    for CD81 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD81 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P60033

    ProtoNet protein and cluster: P60033

    UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Function
    for CD81 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD81_HUMAN, P60033
    Function: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein
    to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV

         Genatlas biochemistry entry for CD81:
    integral membrane protein (26kDa),associated with CD19,B cell surface molecule,expressed on many cell types,target of
    an antiproliferative antibody

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11504738
         
    CD81 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CD81:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cd81):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  nervous system  respiratory system  skeleton 

    CD81 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for CD81: Cd81tm1Lvy Cd81tm1Tmiy Cd81tm1Geha
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD81 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CD81
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD81
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CD81 (see all 14):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-1237 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmid: CD81 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD81 (see all 7)
    OriGene shRNA RFP: CD81
    OriGene siRNA: CD81
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD81
    Sirion Biotech Custom design and validation of potent shRNA sequences against CD81 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD81
    Sirion Biotech Customized adenovirus for overexpression of CD81 
    Sirion Biotech Customized adenovirus for potent knockdown of CD81

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD81 (see all 3)
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD81 

    Cell Line
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    Search LifeMap BioReagents cell lines for CD81
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    Sirion Biotech Customized stable overexpressing cell line services for CD81
    Sirion Biotech Customized inducible overexpressing cell line services for CD81

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD81


    Pathways & Interactions
    for CD81 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2Immune response BCR pathway
    		Immune response BCR pathway1.00
    		Immune response_BCR pathway0.99
    3B cell receptor signaling pathway
    		B cell receptor signaling pathway1.00
    		PI3K Signaling in B-Lymphocyte0.35
    4B Cell Receptor Signaling Pathway
    		B Cell Receptor Signaling Pathway1.00
    5Hepatitis C
    		Hepatitis C1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CD81
        Immune response BCR pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CD81
        PI3K Signaling in B-Lymphocyte

    1 GeneGo (Thomson Reuters) Pathway for CD81
        Immune response BCR pathway

    1 BioSystems Pathway for CD81 
        B Cell Receptor Signaling Pathway

    3        Reactome Pathways for CD81
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    3         Kegg Pathways  (Kegg details for CD81):
        B cell receptor signaling pathway
    Malaria
    Hepatitis C


    CD81 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD81

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for CD81 (P600332, 3 ENSP000002636454) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD19P153912, 3, ENSP000003134194MINT-8407185 I2D: score=3 STRING: ENSP00000313419
    IGSF8Q969P02, 3, ENSP000003166644MINT-8407185 I2D: score=2 STRING: ENSP00000316664
    PTGFRNQ9P2B22, 3, ENSP000003768994MINT-8407185 I2D: score=2 STRING: ENSP00000376899
    CD63P089622, 3, ENSP000002578574MINT-8407185 I2D: score=1 STRING: ENSP00000257857
    ZBTB16Q055162, 3MINT-63913 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA14676841
    GO:0006661phosphatidylinositol biosynthetic process IDA14676841
    GO:0008104protein localization IDA14676841
    GO:0008283cell proliferation TAS1695320
    GO:0008284positive regulation of cell proliferation IDA14676841

    CD81 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD81 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD81 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD81
    10 Novoseek chemical compound relationships for CD81 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribavirin 45.6 7 11391542 (3), 19780859 (1), 16735696 (1), 16623441 (1)
    digitonin 41.1 6 9804823 (3), 10229664 (2), 12938224 (1)
    ganglioside 22.3 3 15248289 (1), 15710618 (1)
    tyrosine 5.56 2 12645944 (1), 8683154 (1)
    calcium 2.64 1 12645944 (1)
    cholesterol 0 6 15004227 (1), 12938224 (1), 19476617 (1)
    lipid 0 3 12645944 (1), 11113129 (1)
    phosphatidylinositol 0 3 9006891 (2), 11113129 (1)
    polysaccharide 0 2 10623732 (1), 17507469 (1)
    cysteine 0 3 14966136 (1), 19328198 (1)

    Search CenterWatch for drugs/clinical trials and news about CD81 

    Transcripts
    for CD81 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD81 gene: 
    NM_004356.3  

    Unigene Cluster for CD81:

    CD81 molecule
    Hs.54457  [show with all ESTs]
    Unigene Representative Sequence: AB209380
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475945 ENST00000530648 ENST00000263645(uc001lwf.1) ENST00000533417
    ENST00000492627 ENST00000527343 ENST00000464784 ENST00000493525 ENST00000381036
    ENST00000492252 ENST00000526072 ENST00000524805 ENST00000530239 ENST00000531840
    ENST00000481687 ENST00000468153 ENST00000481386

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD81
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CD81 (see all 14):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-1237 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmid: CD81 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD81 (see all 7)
    OriGene shRNA RFP: CD81
    OriGene siRNA: CD81
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD81
    Sirion Biotech Custom design and validation of potent shRNA sequences against CD81 
    Clone
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    Additional cDNA sequence: 

    AB209380.1 BC002978.1 BC093047.1 BT019507.1 BT019508.1 M33680.1 

    24/29 DOTS entries (see all 29):

    DT.92453568  DT.100885968  DT.100040647  DT.451059  DT.97864485  DT.95157455  DT.451056  DT.91689119 
    DT.91978911  DT.120734561  DT.100769546  DT.100885965  DT.95157374  DT.100885949  DT.100885952  DT.120734601 
    DT.101985222  DT.120734607  DT.121632864  DT.97856641  DT.100885951  DT.100885953  DT.120734553  DT.120734571 

    24/858 AceView cDNA sequences (see all 858):

    BF725664 BF747665 BX336476 BQ000251 BG818924 CR604204 H68105 BM981166 
    CR605197 AI890012 CD370454 CR597052 CF126432 AA290934 AI418809 BE874004 
    BQ719025 BM982442 W52174 BI013033 CA418965 AA461283 BQ883552 BU751874 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CD81 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
    SP1:                    -     -     -     -     -     -     -           -     -           -           -                                       
    SP2:                                      -     -     -     -           -     -           -           -                                       
    SP3:                                -     -     -     -     -           -     -           -           -                                       
    SP4:                                                                    -     -           -           -                                       
    SP5:                                            -     -     -           -     -           -           -                                       


    ECgene alternative splicing isoforms for CD81

    Expression
    for CD81 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD81 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    CD81 Expression
    About this image

    CD81 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Immature hepatocytes (Functional, immature...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CD81 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD81

    SOURCE GeneReport for Unigene cluster: Hs.54457

    UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
    Tissue specificity: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including CD81: 
              T-cell & B-cell Activation in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD81
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD81

    Orthologs
    for CD81 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CD81 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CD811 CD81 molecule 78.12(n)
    80.37(a)    		   374256  NM_001030339.1  NP_001025510.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CD816
    		 --
    		 74(a)
    		 1 ↔ 1
    		 1(69531278-69543934)
    African clawed frog
    (Xenopus laevis)    		 Amphibia cd81-prov2 CD81 antigen (target of antiproliferative antibody more 79.41(n)    BC041217.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cd812 CD81 antigen 79.43(n)   58031  AF295377.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tsp96F1 Tetraspanin 96F 47.79(n)
    31.42(a)    		   43127  NM_079776.2  NP_524500.1 


    ENSEMBL Gene Tree for CD81 (if available)
    TreeFam Gene Tree for CD81 (if available) 

    Paralogs
    for CD81 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD81 gene
    TSPAN22  CD92  
    12 SIMAP similar genes for CD81 using alignment to 11 protein entries:     CD81_HUMAN (see all proteins):
    BTCC-1    CD9    CD82    TSPAN2    TSPAN8    TSPAN5
    TSPAN11    TSPAN4    CD53    TSPAN9    TSPAN18    CD151

    CD81 for paralogs           About GeneDecksing



    Genomic Variants
    for CD81 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/455 NCBI SNPs in CD81 are shown (see all 455)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1876705661,2
    		--2396554(+) TCCCCA/GGCTCT 1 -- us2k10--------
    rs1142602761,2
    		C,F--2396661(+) GCCCCA/GACCCT 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs7081541,2
    		C,F,A,H--2396666(+) AACCCC/TGTGAC 1 -- us2k125Minor allele frequency- T:0.21NS EA NA WA CSA 2349
    rs1156436861,2
    		F--2396726(+) CCATCG/ATGCTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1400994911,2
    		--2396749(+) TCTCCA/GCCAGA 1 -- us2k10--------
    rs788526671,2
    		C--2396765(+) AGATCC/TTCCAG 1 -- us2k10--------
    rs1908640761,2
    		--2396783(+) GTCTGC/TTGCCT 1 -- us2k10--------
    rs1808844741,2
    		--2396898(+) CATGGC/TCTGCT 1 -- us2k10--------
    rs1433734201,2
    		--2396927(+) GGACAC/TAGTGT 1 -- us2k10--------
    rs1172379551,2
    		--2396955(+) CCTCCC/TACTTC 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for CD81 (2397407 - 2418649 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CD81
         2 CNVs: 29895 29896
    Human Gene Mutation Database (HGMD): CD81

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD81
    DNA2.0 Custom Variant and Variant Library Synthesis for CD81

    Disorders / Diseases
    for CD81 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD81 for disorders           About GeneDecksing

    OMIM gene information: 186845   
    OMIM disorders: 613496  
    UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
  • Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:613496]; also called
    • antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency,
    hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The
    defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of
    circulating B-cells is usually in the normal range, but can be low

    20/29 diseases for CD81 (see all 29):    About MalaCards
    immunodeficiency, common variable, 6    dengue hemorrhagic fever    hemorrhagic fever    hepatitis c
    acute lymphoblastic leukemia    chronic lymphocytic leukemia    lymphoblastic leukemia    lymphocytic leukemia
    hepatitis b    cryoglobulinemia    multiple myeloma    hepatocellular carcinoma
    hepatitis    immunodeficiency    leukemia    myeloma
    pulmonary disease    glioblastoma    malaria    carcinoma

    4 diseases from the University of Copenhagen DISEASES database for CD81:
    Hepatitis C     Liver disease     Cryoglobulinemia     Hepatocellular carcinoma

    10/17 Novoseek disease relationships for CD81 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c 78.9 56 12645944 (2), 14722300 (2), 19489072 (2), 11024134 (2) (see all 45)
    hepatitis c chronic 57.3 9 11130883 (2), 16735696 (2), 16623441 (1), 11391542 (1) (see all 7)
    virus infection 47 17 11985527 (2), 14722300 (1), 11602742 (1), 20512986 (1) (see all 15)
    hepatocellular carcinoma 31.6 6 11115611 (2), 12210407 (1), 11130883 (1), 16819966 (1)
    lymphoproliferative disorders 21.8 2 17177963 (1), 12558906 (1)
    metastasis 14.1 8 15698400 (2), 11115611 (2), 18466772 (1), 9597125 (1)
    immunodeficiency 9.99 2 17177963 (1), 15767432 (1)
    lymphoma b-cell 9.45 6 20004001 (3)
    hepatitis 1.25 1 11130883 (1)
    necrosis 0 2 8668914 (1), 18805782 (1)

    Genetic Association Database (GAD): CD81
    Human Genome Epidemiology (HuGE) Navigator: CD81 (15 documents)

    Export disorders for CD81 gene to outside databases

    Publications
    for CD81 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD81 gene, integrated from 9 sources (see all 319):
    (articles sorted by number of sources associating them with CD81)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. (PubMed id 1695320)1, 2, 9 Oren R.... Levy S. (1990)
    2. Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. (PubMed id 12437138)1, 2, 9 Kitadokoro K.... Bolognesi M. (2002)
    3. Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. (PubMed id 12913001)1, 2, 9 Bartosch B.... Cosset F.-L. (2003)
    4. CD81 gene defect in humans disrupts CD19 complex form ation and leads to antibody deficiency. (PubMed id 20237408)1, 2 van Zelm M.C....van der Burg M. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. CD81-dependent binding of hepatitis C virus E1E2 heterodimers. (PubMed id 12970454)1, 2 Cocquerel L.... Levy S. (2003)
    7. Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection. (PubMed id 12209363)1, 4 Hennig B.J....Hill A.V. (2002)
    8. CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs. (PubMed id 11226150)1, 2 Kitadokoro K.... Bolognesi M. (2001)
    9. EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PubMed id 11504738)1, 2 Stipp C.S.... Hemler M.E. (2001)
    10. Structure and membrane topology of TAPA-1. (PubMed id 1860863)1, 2 Levy S.... Takahashi S. (1991)

    External Searches for CD81 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CD81 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 975 HGNC: 1701 AceView: CD81 Ensembl:ENSG00000110651 euGenes: HUgn975
    ECgene: CD81 Kegg: 975 H-InvDB: CD81

    Other Databases showing CD81 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD81 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD81 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD81 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CD81 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD81 gene:
    Search GeneIP for patents involving CD81

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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