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CD81 Gene

protein-coding   GIFtS: 66
GCID: GC11P002397

CD81 Molecule

(Previous name: CD81 antigen (target of antiproliferative antibody 1))
(Previous symbol: TAPA1)
  See CD81-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD81 Molecule1 2     S5.72
TAPA11 2 3 5     tetraspanin-282
CD81 Antigen (Target Of Antiproliferative Antibody 1)1 2     tspan-282
26 KDa Cell Surface Protein TAPA-12 3     Tetraspanin-283
TSPAN282 3     Tspan-283
CD81 Antigen2 3     Target Of The Antiproliferative Antibody 13
CVID62 5     

External Ids:    HGNC: 17011   Entrez Gene: 9752   Ensembl: ENSG000001106517   OMIM: 1868455   UniProtKB: P600333   

Export aliases for CD81 gene to outside databases

Previous GC identifers: GC11P002460 GC11P002599 GC11P002356 GC11P002363 GC11P002355 GC11P002188


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD81 Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known
to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance.
Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and
thus it is a candidate gene for malignancies. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD81 Gene:
CD81 (CD81 molecule) is a protein-coding gene. Diseases associated with CD81 include immunodeficiency, common variable, 6, and immunodeficiency, common variable, 9. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is TSPAN2.

UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
Function: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13
protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV

Gene Wiki entry for CD81 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD81 gene promoter:
         STAT1   MAZR   Pax-5   Brachyury   STAT1beta   Lmo2   STAT1alpha   Gfi-1   ZIC2/Zic2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD81 promoter sequence
   Search Chromatin IP Primers for CD81

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD81


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

CD81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD81 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P002397:  view genomic region     (about GC identifiers)

Start:
2,397,407 bp from pter      End:
2,418,649 bp from pter
Size:
21,243 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD81_HUMAN, P60033 (See protein sequence)
Recommended Name: CD81 antigen  
Size: 236 amino acids; 25809 Da
Subunit: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins
heterodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM1, IFITM2 and
IFITM3. Part of a GPCR-tetraspanin complex consisting at least of GPR56, CD81, eventually CD9, and GNA11 in which
CD81 is enhancing the association of GPR56 with GNA11
3 PDB 3D structures from and Proteopedia for CD81:
1G8Q (3D)        1IV5 (3D)        2AVZ (3D)    
Secondary accessions: P18582 Q5U0J6

Explore the universe of human proteins at neXtProt for CD81: NX_P60033

Explore proteomics data for CD81 at MOPED

Post-translational modifications: 

  • Not glycosylated (Probable)1
  • Ubiquitination2 at Lys124, Lys144, Lys148
  • Modification sites at PhosphoSitePlus

  • See CD81 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004347.1  
    ENSEMBL proteins: 
     ENSP00000433178   ENSP00000432723   ENSP00000263645   ENSP00000435633   ENSP00000437242  
     ENSP00000433767   ENSP00000433904   ENSP00000432497   ENSP00000370424   ENSP00000432249  
     ENSP00000431780   ENSP00000432033  
    Reactome Protein details: P60033

    CD81 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CD81
    Sino Biological Cell Lysate for CD81
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD81 

    CD81 Antibody Products:

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    R&D Systems Antibodies for CD81
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    Abcam antibodies for CD81
    Browse Antibodies at Cloud-Clone Corp.
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    CD81 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CD81 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P60033

    ProtoNet protein and cluster: P60033

    UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Find genes that share domains with CD81           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD81_HUMAN, P60033
    Function: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13
    protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV

         Genatlas biochemistry entry for CD81:
    integral membrane protein (26kDa),associated with CD19,B cell surface molecule,expressed on many cell types,target
    of an antiproliferative antibody

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10400713
    GO:0023026MHC class II protein complex binding IDA--
         
    Find genes that share ontologies with CD81           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CD81:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd81):
     behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     nervous system  respiratory system  skeleton 

    Find genes that share phenotypes with CD81           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD81: Cd81tm1Lvy Cd81tm1Tmiy Cd81tm1Geha

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD81
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD81

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD81
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD81

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD81:
    hsa-let-7b-5p (MIRT052151), hsa-mir-769-3p (MIRT039120), hsa-mir-1260b (MIRT052737), hsa-mir-423-5p (MIRT038125), hsa-mir-155-5p (MIRT020808)

    Block miRNA regulation of human, mouse, rat CD81 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD81 (see all 14):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-1237 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidCD81 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD81
    Predesigned siRNA for gene silencing in human, mouse, rat CD81

    Gene Editing
    Products:
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    GenScript: all cDNA clones in your preferred vector: CD81 (NM_004356)
    Sino Biological Human cDNA Clone for CD81
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD81
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD81
    Addgene plasmids for CD81 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CD81 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD81


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD81_HUMAN, P60033: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    endosome2
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA14676841
    GO:0016021integral component of membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CD81           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD81 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.43
    2B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    3Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    4ErbB4 Pathway
    PI3K Signaling in B-Lymphocyte0.35
    5Malaria
    Malaria


    Find genes that share SuperPaths with CD81           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CD81
        PI3K Signaling in B-Lymphocyte

    1 GeneGo (Thomson Reuters) Pathway for CD81
        Immune response BCR pathway

    1 BioSystems Pathway for CD81
        B Cell Receptor Signaling Pathway


    1 Reactome Pathway for CD81
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    3 Kegg Pathways  (Kegg details for CD81):
        B cell receptor signaling pathway
    Malaria
    Hepatitis C

        Pathway & Disease-focused RT2 Profiler PCR Array including CD81: 
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD81

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD81 (P600331, 2, 3 ENSP000002636454) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD19P153912, 3, ENSP000003134194MINT-8407185 I2D: score=3 STRING: ENSP00000313419
    IGSF8Q969P02, 3, ENSP000003166644MINT-8407185 I2D: score=2 STRING: ENSP00000316664
    PTGFRNQ9P2B22, 3, ENSP000003768994MINT-8407185 I2D: score=2 STRING: ENSP00000376899
    CD63P089622, 3, ENSP000002578574MINT-8407185 I2D: score=1 STRING: ENSP00000257857
    ZBTB16Q055162, 3MINT-63913 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA14676841
    GO:0006661phosphatidylinositol biosynthetic process IDA14676841
    GO:0008104protein localization IDA14676841
    GO:0008283cell proliferation TAS1695320
    GO:0008284positive regulation of cell proliferation IDA14676841

    Find genes that share ontologies with CD81           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD81

    10 Novoseek inferred chemical compound relationships for CD81 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribavirin 45.6 7 11391542 (3), 19780859 (1), 16735696 (1), 16623441 (1)
    digitonin 41.1 6 9804823 (3), 10229664 (2), 12938224 (1)
    ganglioside 22.3 3 15248289 (1), 15710618 (1)
    tyrosine 5.56 2 12645944 (1), 8683154 (1)
    calcium 2.64 1 12645944 (1)
    cholesterol 0 6 15004227 (1), 12938224 (1), 19476617 (1)
    lipid 0 3 12645944 (1), 11113129 (1)
    phosphatidylinositol 0 3 9006891 (2), 11113129 (1)
    polysaccharide 0 2 10623732 (1), 17507469 (1)
    cysteine 0 3 14966136 (1), 19328198 (1)



    Find genes that share compounds with CD81           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD81 gene: 
    NM_004356.3  

    Unigene Cluster for CD81:

    CD81 molecule
    Hs.54457  [show with all ESTs]
    Unigene Representative Sequence: AB209380
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475945 ENST00000530648 ENST00000263645(uc001lwf.1) ENST00000533417
    ENST00000492627 ENST00000527343 ENST00000464784 ENST00000493525 ENST00000381036
    ENST00000492252 ENST00000526072 ENST00000524805 ENST00000530239 ENST00000531840
    ENST00000481687 ENST00000468153 ENST00000481386
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CD81 (see all 14):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-1237 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidCD81 3' UTR sequence
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    Addgene plasmids for CD81 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD81
      QuantiTect SYBR Green Assays in human, mouse, rat CD81
      QuantiFast Probe-based Assays in human, mouse, rat CD81

    Additional mRNA sequence: 

    AB209380.1 BC002978.1 BC093047.1 BT019507.1 BT019508.1 M33680.1 

    Selected DOTS entries (see all 29):

    DT.92453568  DT.100885968  DT.100040647  DT.451059  DT.97864485  DT.95157455  DT.451056  DT.91689119 
    DT.91978911  DT.120734561  DT.100769546  DT.100885965  DT.95157374  DT.100885949  DT.100885952  DT.120734601 
    DT.101985222  DT.120734607  DT.121632864  DT.97856641  DT.100885951  DT.100885953  DT.120734553  DT.120734571 

    Selected AceView cDNA sequences (see all 858):

    BQ691409 CA434584 BU855031 AW376145 BI013033 BM851827 BM824083 BG818924 
    BM686605 H68105 CA443811 BQ638564 CA426345 CB147356 CR598183 BQ008787 
    CR604916 BU618573 AW498938 W52174 BX336476 BQ220247 BG684377 BG823665 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD81 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
    SP1:                    -     -     -     -     -     -     -           -     -           -           -                                       
    SP2:                                      -     -     -     -           -     -           -           -                                       
    SP3:                                -     -     -     -     -           -     -           -           -                                       
    SP4:                                                                    -     -           -           -                                       
    SP5:                                            -     -     -           -     -           -           -                                       


    ECgene alternative splicing isoforms for CD81

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CD81 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD81 Expression
    About this image


    CD81 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Immature hepatocytes
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    CD81 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD81 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.54457

    UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
    Tissue specificity: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including CD81: 
              T-cell & B-cell Activation in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD81

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CD81 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd811 , 5 CD81 antigen1, 5 86.72(n)1
    91.95(a)1
      7 (88.10 cM)5
    125201  NM_133655.21  NP_598416.11 
     1430527395 
    chicken
    (Gallus gallus)
    Aves CD811 CD81 molecule 78.32(n)
    80.37(a)
      374256  NM_001030339.1  NP_001025510.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD816
    CD81 molecule
    75(a)
    1 ↔ 1
    1(69531278-69543934)
    African clawed frog
    (Xenopus laevis)
    Amphibia cd81-prov2 CD81 antigen (target of antiproliferative antibody more 79.41(n)    BC041217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cd812 CD81 antigen 79.43(n)   58031  AF295377.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp96F1 Tetraspanin 96F 47.58(n)
    31.28(a)
      43127  NM_079776.2  NP_524500.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-96
    Protein TSP-9 (tsp-9) mRNA, complete cds
    26(a)
    1 → many
    X(1246017-1247499) WBGene00006635


    ENSEMBL Gene Tree for CD81 (if available)
    TreeFam Gene Tree for CD81 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD81 gene
    TSPAN22  CD92  TSPAN12  CD372  TSPAN92  CD532  CD822  TSPAN182  
    TSPAN42  TSPAN82  
    10 SIMAP similar genes for CD81 using alignment to 11 protein entries:     CD81_HUMAN (see all proteins):
    BTCC-1    CD9    CD82    TSPAN2    TSPAN8    TSPAN5
    TSPAN11    TSPAN4    CD53    TSPAN9

    Find genes that share paralogs with CD81           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD81 (see all 569)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876705661,2
    --2396554(+) TCCCCA/GGCTCT 1 -- us2k10--------
    rs1142602761,2
    C,F--2396661(+) GCCCCA/GACCCT 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs7081541,2
    C,F,A,H--2396666(+) AACCCC/TGTGAC 1 -- us2k125Minor allele frequency- T:0.21NS EA NA WA CSA 2349
    rs1156436861,2
    C,F--2396726(+) CCATCG/ATGCTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1400994911,2
    --2396749(+) TCTCCA/GCCAGA 1 -- us2k10--------
    rs788526671,2
    C--2396765(+) AGATCC/TTCCAG 1 -- us2k10--------
    rs1908640761,2
    --2396783(+) GTCTGC/TTGCCT 1 -- us2k10--------
    rs1808844741,2
    --2396898(+) CATGGC/TCTGCT 1 -- us2k10--------
    rs1433734201,2
    --2396927(+) GGACAC/TAGTGT 1 -- us2k10--------
    rs1172379551,2
    F--2396955(+) CCTCCC/TACTTC 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for CD81 (2397407 - 2418649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CD81 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1007864CNV Deletion20482838
    esv1285833CNV Deletion17803354
    esv2744006CNV Deletion23290073
    nsv509382CNV Insertion20534489
    nsv896812CNV Loss21882294
    nsv469928CNV Loss18288195
    nsv896806CNV Loss21882294
    dgv1000n71CNV Loss21882294
    nsv896816CNV Loss21882294
    nsv896811CNV Loss21882294

    Human Gene Mutation Database (HGMD): CD81
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD81
    DNA2.0 Custom Variant and Variant Library Synthesis for CD81

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186845   
    OMIM disorders: 613496  
    UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
  • Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by
    antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody
    response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of
    immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for CD81:    
    About MalaCards
    immunodeficiency, common variable, 6    immunodeficiency, common variable, 9    cerebral creatine deficiency syndrome    malaria

    4 diseases from the University of Copenhagen DISEASES database for CD81:
    Hepatitis C     Cryoglobulinemia     Liver disease     Hepatocellular carcinoma

    Find genes that share disorders with CD81           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD81 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c 78.9 56 12645944 (2), 14722300 (2), 19489072 (2), 11024134 (2) (see all 45)
    hepatitis c chronic 57.3 9 11130883 (2), 16735696 (2), 16623441 (1), 11391542 (1) (see all 7)
    virus infection 47 17 11985527 (2), 14722300 (1), 11602742 (1), 20512986 (1) (see all 15)
    hepatocellular carcinoma 31.6 6 11115611 (2), 12210407 (1), 11130883 (1), 16819966 (1)
    lymphoproliferative disorders 21.8 2 17177963 (1), 12558906 (1)
    metastasis 14.1 8 15698400 (2), 11115611 (2), 18466772 (1), 9597125 (1)
    immunodeficiency 9.99 2 17177963 (1), 15767432 (1)
    lymphoma b-cell 9.45 6 20004001 (3)
    hepatitis 1.25 1 11130883 (1)
    necrosis 0 2 8668914 (1), 18805782 (1)

    Genetic Association Database (GAD): CD81
    Human Genome Epidemiology (HuGE) Navigator: CD81 (15 documents)

    Export disorders for CD81 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD81 gene, integrated from 10 sources (see all 340):
    (articles sorted by number of sources associating them with CD81)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. (PubMed id 1695320)1, 2, 9 Oren R.... Levy S. (Mol. Cell. Biol. 1990)
    2. Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. (PubMed id 12437138)1, 2, 9 Kitadokoro K.... Bolognesi M. (Biol. Chem. 2002)
    3. Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. (PubMed id 12913001)1, 2, 9 Bartosch B.... Cosset F.-L. (J. Biol. Chem. 2003)
    4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    6. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    7. CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. (PubMed id 20237408)1, 2 van Zelm M.C....van der Burg M. (J. Clin. Invest. 2010)
    8. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    9. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    10. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 975 HGNC: 1701 AceView: CD81 Ensembl:ENSG00000110651 euGenes: HUgn975
    ECgene: CD81 Kegg: 975 H-InvDB: CD81

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD81 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD81 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD81 gene:
    Search GeneIP for patents involving CD81

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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