Aliases for CD81 Gene
Aliases for CD81 Gene
External Ids for CD81 Gene
- HGNC: 1701
- Entrez Gene: 975
- Ensembl: ENSG00000110651
- OMIM: 186845
- UniProtKB: P60033
Previous HGNC Symbols for CD81 Gene
- TAPA1
Previous GeneCards Identifiers for CD81 Gene
- GC11P002460
- GC11P002599
- GC11P002356
- GC11P002363
- GC11P002355
- GC11P002188
Summaries for CD81 Gene
-
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for CD81 Gene
CD81 (CD81 Molecule) is a Protein Coding gene. Diseases associated with CD81 include Immunodeficiency, Common Variable, 6 and Common Variable Immunodeficiency. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is CD9.
UniProtKB/Swiss-Prot for CD81 Gene
-
May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD81 Gene
Genomics for CD81 Gene
Regulatory Elements for CD81 Gene
Enhancers for CD81 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CD81 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CD81 gene promoter:
Regulatory Element Products
Genomic Location for CD81 Gene
- Chromosome:
- 11
- Start:
- 2,376,177 bp from pter
- End:
- 2,397,419 bp from pter
- Size:
- 21,243 bases
- Orientation:
- Plus strand
Genomic View for CD81 Gene
Genes around CD81 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.5 by Ensembl
- 11p15.5 by Entrez Gene
- 11p15.5 by HGNC
CD81 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD81 Gene
Proteins for CD81 Gene
-
Protein details for CD81 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P60033-CD81_HUMAN
- Recommended name:
- CD81 antigen
- Protein Accession:
- P60033
- P18582
- Q5U0J6
Protein attributes for CD81 Gene
- Size:
- 236 amino acids
- Molecular mass:
- 25809 Da
- Quaternary structure:
-
- Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of ADGRG1 with GNA11.
Protein Expression for CD81 Gene
Post-translational modifications for CD81 Gene
- Not glycosylated.
- Ubiquitination at Lys124, Lys144, and Lys148
- Modification sites at PhosphoSitePlus
Other Protein References for CD81 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CD81
- R&D Systems Antibodies for CD81 (CD81)
- Novus Biologicals Antibodies for CD81
-
Abcam antibodies for CD81
-
Cloud-Clone Corp. Antibodies for CD81
- Invitrogen Antibodies for CD81
- antibodies-online Antibodies for CD81: See all 301
- GeneTex CD81 antibody for CD81
-
Custom Antibody ServicesProSci Antibodies for CD81
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD81
Protein Products
- R&D Systems Proteins and Enzymes for CD81
-
OriGene Purified Proteins for CD81
- Search Origene for MassSpec and Protein Over-expression Lysates for CD81
- Origene Custom Protein Services for CD81
- Sino Biological Recombinant Proteins for CD81
- Sino Biological Cell Lysates for CD81
-
Cloud-Clone Corp. Proteins for CD81
- antibodies-online Proteins for CD81: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CD81
-
Abcam proteins for CD81
No data available for DME Specific Peptides for CD81 Gene
Domains & Families for CD81 Gene
Gene Families for CD81 Gene
Protein Domains for CD81 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD81 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P60033- Family:
-
- Belongs to the tetraspanin (TM4SF) family.
Function for CD81 Gene
Molecular function for CD81 Gene
- GENATLAS Biochemistry:
- integral membrane protein (26kDa),associated with CD19,B cell surface molecule,expressed on many cell types,target of an antiproliferative antibody
- UniProtKB/Swiss-Prot Function:
- May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IMP | 20375010 |
| GO:0005515 | protein binding | IPI | 2398277 |
| GO:0023026 | MHC class II protein complex binding | IDA | 20458337 |
| GO:1990459 | transferrin receptor binding | IPI | 25635054 |
Phenotypes for CD81 Gene
- MGI mutant phenotypes for CD81:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CD81:
-
- Increased gamma-H2AX phosphorylation
- Synthetic lethal with Ras
- Decreased ionizing radiation sensitivity
- Decreased shRNA abundance (Z-score < -2)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased influenza A/WSN/33 replication
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
Animal Model Products
-
Taconic Biosciences Mouse Models for CD81
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD81
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CD81 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD81 gene
- Search ViGene Biosciences for CD81
CRISPR Products
-
OriGene CRISPR knockouts for CD81
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD81
- GenScript: Design CRISPR guide RNA sequences for CD81
miRNA for CD81 Gene
- miRTarBase miRNAs that target CD81
-
- hsa-mir-155-5p (MIRT020808)
- hsa-mir-423-5p (MIRT038125)
- hsa-mir-769-3p (MIRT039120)
- hsa-let-7b-5p (MIRT052151)
- hsa-mir-1260b (MIRT052737)
- hsa-mir-582-5p (MIRT180201)
- hsa-mir-1265 (MIRT180203)
- hsa-mir-6504-3p (MIRT180207)
- hsa-mir-8070 (MIRT180208)
- hsa-mir-3937 (MIRT332487)
- hsa-mir-4672 (MIRT332490)
- hsa-mir-4789-5p (MIRT332491)
- hsa-mir-6768-5p (MIRT332492)
- hsa-mir-3152-3p (MIRT332510)
- hsa-mir-5702 (MIRT332514)
- hsa-mir-6126 (MIRT332515)
- hsa-mir-6864-5p (MIRT479632)
- hsa-mir-4493 (MIRT479633)
- hsa-mir-605-3p (MIRT479634)
- hsa-mir-552-3p (MIRT479635)
- hsa-mir-8080 (MIRT479636)
- hsa-mir-101-3p (MIRT479637)
- hsa-mir-190a-3p (MIRT479638)
miRNA Products
- Search ViGene Biosciences for CD81
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CD81
- Browse OriGene Inhibitory RNA Products For CD81
-
ViGene Biosciences ready-to-package AAV shRNAs for CD81 gene
Clone Products
- Sino Biological Human cDNA Clone for CD81
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CD81
- VectorBuilder custom plasmid, inducible vectors for CD81
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD81
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CD81
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CD81 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD81 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD81 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD81 Gene
Localization for CD81 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD81 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 3 |
| endosome | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001772 | immunological synapse | IDA | 21930792 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 14676841 |
| GO:0005925 | focal adhesion | IDA | 21423176 |
| GO:0016020 | membrane | IDA,IEA | 19946888 |
Pathways & Interactions for CD81 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | B cell receptor signaling pathway (KEGG) | ||
| 2 | Hepatitis C | ||
| 3 | Malaria |
-
|
|
| 4 | IL-2 Pathway | ||
| 5 | Class I MHC mediated antigen processing and presentation | ||
Pathways by source for CD81 Gene
1 BioSystems pathway for CD81 Gene
3 Reactome pathways for CD81 Gene
3 KEGG pathways for CD81 Gene
1 GeneGo (Thomson Reuters) pathway for CD81 Gene
1 Qiagen pathway for CD81 Gene
Interacting Proteins for CD81 Gene
Selected Interacting proteins:
ENSP00000263645
P60033-CD81_HUMAN
for CD81 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IDA | 14676841 |
| GO:0007166 | cell surface receptor signaling pathway | IBA | -- |
| GO:0008104 | protein localization | IDA | 14676841 |
| GO:0008283 | cell proliferation | TAS | 1695320 |
| GO:0008284 | positive regulation of cell proliferation | IDA | 14676841 |
No data available for SIGNOR curated interactions for CD81 Gene
Transcripts for CD81 Gene
mRNA/cDNA for CD81 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (858) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CD81
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD81
- GenScript: Design CRISPR guide RNA sequences for CD81
miRNA Products
- Search ViGene Biosciences for CD81
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CD81
- Browse OriGene Inhibitory RNA Products For CD81
-
ViGene Biosciences ready-to-package AAV shRNAs for CD81 gene
Clone Products
- Sino Biological Human cDNA Clone for CD81
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CD81
- VectorBuilder custom plasmid, inducible vectors for CD81
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD81
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CD81
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP9: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP12: | - |
Expression for CD81 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Liver (Hepatobiliary System)
This gene is overexpressed in Frontal cortex (7.5) and Spinal cord (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD81 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CD81 Gene:
CD81SOURCE GeneReport for Unigene cluster for CD81 Gene:
Hs.54457mRNA Expression by UniProt/SwissProt for CD81 Gene:
P60033-CD81_HUMAN
Tissue specificity:
Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.
Evidence on tissue expression from TISSUES for CD81 Gene
- Nervous system(4.9)
- Lung(4.3)
- Skin(3.7)
- Liver(3.6)
- Lymph node(3.3)
- Pancreas(3.3)
- Spleen(3.2)
- Heart(3)
- Blood(2.8)
- Intestine(2.8)
- Muscle(2.8)
- Kidney(2.7)
- Bone marrow(2.5)
- Gall bladder(2.5)
- Eye(2.4)
- Thyroid gland(2.4)
- Adrenal gland(2.2)
- Stomach(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CD81 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- ear
- eye
- head
- hypothalamus
- meninges
- middle ear
- neck
- pituitary gland
- sinus
- skull
- thyroid
Thorax:
- bronchus
- heart
- lung
Abdomen:
- adrenal gland
- intestine
- large intestine
- liver
- small intestine
- spleen
- stomach
Pelvis:
- anus
- rectum
- uterus
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- lymph node
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CD81
-
OriGene qPCR primer pairs and template standards for CD81
No data available for mRNA differential expression in normal tissues for CD81 Gene
Orthologs for CD81 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD81 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CD81 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC611606 34 |
|
||
| CD81 35 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Cd81 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd81 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | TAPA1 35 |
|
OneToOne | |
| CD81 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | CD81 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cd81 34 |
|
||
| MGC75667 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | cd81-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cd81 34 35 |
|
||
| CD81 (1 of 2) 35 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000823 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Tsp96F 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | tsp-9 35 |
|
OneToMany |
- Species where no ortholog for CD81 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CD81 Gene
Paralogs for CD81 Gene
(10) SIMAP similar genes for CD81 Gene using alignment to 11 proteins:
Variants for CD81 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs587776775 | Pathogenic | 2,395,971(+) | TCAAG(A/G)TGCGC | splice-donor-variant | |
| rs1000018888 | -- | 2,391,973(+) | CCTCC(C/T)AGCCA | intron-variant | |
| rs1000045433 | -- | 2,377,012(+) | GCACT(C/G)CTGGG | intron-variant, upstream-variant-2KB | |
| rs1000131388 | -- | 2,392,198(+) | AAGGC(C/T)TGTGG | intron-variant | |
| rs1000250300 | -- | 2,391,628(+) | GAGGG(A/T)TTCTG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1568n54 | CNV | loss | 21841781 |
| dgv1569n54 | CNV | loss | 21841781 |
| esv1007864 | CNV | deletion | 20482838 |
| esv1285833 | CNV | deletion | 17803354 |
| esv2744006 | CNV | deletion | 23290073 |
| nsv1070001 | CNV | deletion | 25765185 |
| nsv1115318 | CNV | deletion | 24896259 |
| nsv1151445 | CNV | deletion | 26484159 |
| nsv467645 | CNV | gain | 19166990 |
| nsv469928 | CNV | loss | 18288195 |
| nsv509382 | CNV | insertion | 20534489 |
| nsv553047 | CNV | gain | 21841781 |
| nsv553089 | CNV | gain | 21841781 |
| nsv951286 | CNV | deletion | 24416366 |
| nsv951287 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.70;
14.94% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CD81 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD81 Gene
Disorders for CD81 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency, common variable, 6 |
|
|
| common variable immunodeficiency |
|
|
| hepatitis c |
|
|
| hepatitis |
|
|
| cryoglobulinemia |
|
|
Search CD81 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CD81_HUMAN- Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:20237408}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CD81
No data available for Genatlas for CD81 Gene
Publications for CD81 Gene
- Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. (PMID: 12437138) Kitadokoro K. … Bolognesi M. (Biol. Chem. 2002) 3 4 22 64
- TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. (PMID: 1695320) Oren R. … Levy S. (Mol. Cell. Biol. 1990) 3 4 22 64
- SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling. (PMID: 21930792) Draber P. … Brdicka T. (Mol. Cell. Biol. 2011) 3 4 64
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
- Tetraspanin CD81 is required for Listeria monocytogenes invasion. (PMID: 19901060) Tham T.N. … Pizarro-Cerda J. (Infect. Immun. 2010) 3 22 64
Products for CD81 Gene
- R&D Systems Antibodies for CD81 (CD81)
- R&D Systems Proteins and Enzymes for CD81
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for CD81
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CD81
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CD81
- Search Origene for MassSpec and Protein Over-expression Lysates for CD81
- Origene Custom Protein Services for CD81
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CD81
- Browse OriGene Inhibitory RNA Products For CD81
- OriGene qPCR primer pairs and template standards for CD81
- OriGene qPCR primer pairs for CD81
- OriGene CRISPR knockouts for CD81
- OriGene ORF clones in human for CD81
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD81
- GenScript: Next-day shipping cDNA ORF clone for CD81 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CD81
- GenScript Custom Assay Services for CD81
- GenScript Custom overexpressing Cell Line Services for CD81
- GenScript: Design CRISPR guide RNA sequences for CD81
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD81
- Sino Biological Human cDNA Clone for CD81
- Sino Biological Recombinant Proteins for CD81
- Sino Biological Cell Lysates for CD81
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CD81
- Novus Biologicals proteins and lysates for CD81
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CD81
- Abcam proteins for CD81
- Search for Assays for CD81 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for CD81
- Cloud-Clone Corp. Proteins for CD81
- Cloud-Clone Corp Assay Kits for CD81
- Taconic Biosciences Mouse Models for CD81
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for CD81
- antibodies-online Antibodies for CD81: See all 301
- antibodies-online Kits for CD81: See all 6
- antibodies-online Proteins for CD81: See all 11
- Search antibodies-online for peptides
- GeneTex CD81 antibody for CD81
- Search GeneTex for Proteins for CD81
- ViGene Biosciences adenoviral particle packaged cDNA for CD81 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD81 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD81 gene
- Search ViGene Biosciences for CD81
- Santa Cruz Biotechnology (SCBT) Antibodies for CD81
- Search Santa Cruz Biotechnology (SCBT) for CD81 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD81
- Custom Antibody ServicesProSci Antibodies for CD81
- Search for CD81 Proteins at ProSci
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD81
- VectorBuilder custom plasmid, inducible vectors for CD81
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD81
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CD81 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer