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Aliases for CD81 Gene

Aliases for CD81 Gene

  • CD81 Molecule 2 3
  • TAPA1 3 4 6
  • CD81 Antigen (Target Of Antiproliferative Antibody 1) 2 3
  • 26 KDa Cell Surface Protein TAPA-1 3 4
  • Tetraspanin-28 3 4
  • CD81 Antigen 3 4
  • Tspan-28 3 4
  • TSPAN28 3 4
  • CVID6 3 6
  • Target Of The Antiproliferative Antibody 1 4
  • S5.7 3

External Ids for CD81 Gene

Previous HGNC Symbols for CD81 Gene

  • TAPA1

Previous GeneCards Identifiers for CD81 Gene

  • GC11P002460
  • GC11P002599
  • GC11P002356
  • GC11P002363
  • GC11P002355
  • GC11P002188

Summaries for CD81 Gene

Entrez Gene Summary for CD81 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for CD81 Gene

CD81 (CD81 Molecule) is a Protein Coding gene. Diseases associated with CD81 include immunodeficiency, common variable, 6 and common variable immunodeficiency. Among its related pathways are Class I MHC mediated antigen processing and presentation and B Cell Receptor Signaling Pathway (WikiPathways). GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is TSPAN9.

UniProtKB/Swiss-Prot for CD81 Gene

  • May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV

Gene Wiki entry for CD81 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD81 Gene

Genomics for CD81 Gene

Regulatory Elements for CD81 Gene

Genomic Location for CD81 Gene

2,376,161 bp from pter
2,397,419 bp from pter
21,259 bases
Plus strand

Genomic View for CD81 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD81 Gene

Proteins for CD81 Gene

  • Protein details for CD81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD81 antigen
    Protein Accession:
    Secondary Accessions:
    • P18582
    • Q5U0J6

    Protein attributes for CD81 Gene

    236 amino acids
    Molecular mass:
    25809 Da
    Quaternary structure:
    • Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM1, IFITM2 and IFITM3. Part of a GPCR-tetraspanin complex consisting at least of GPR56, CD81, eventually CD9, and GNA11 in which CD81 is enhancing the association of GPR56 with GNA11.

    Three dimensional structures from OCA and Proteopedia for CD81 Gene

neXtProt entry for CD81 Gene

Proteomics data for CD81 Gene at MOPED

Post-translational modifications for CD81 Gene

Antibody Products

No data available for DME Specific Peptides for CD81 Gene

Domains for CD81 Gene

Gene Families for CD81 Gene

Protein Domains for CD81 Gene

Suggested Antigen Peptide Sequences for CD81 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD81: view

Function for CD81 Gene

Molecular function for CD81 Gene

GENATLAS Biochemistry:
integral membrane protein (26kDa),associated with CD19,B cell surface molecule,expressed on many cell types,target of an antiproliferative antibody
UniProtKB/Swiss-Prot Function:
May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV

Gene Ontology (GO) - Molecular Function for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10400713
GO:0023026 MHC class II protein complex binding IDA 20458337
genes like me logo Genes that share ontologies with CD81: view
genes like me logo Genes that share phenotypes with CD81: view

Animal Models for CD81 Gene

MGI Knock Outs for CD81:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD81

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD81 Gene

Localization for CD81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD81 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CD81 Gene COMPARTMENTS Subcellular localization image for CD81 gene
Compartment Confidence
plasma membrane 5
cytosol 3
endosome 2
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 21930792
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 14676841
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CD81: view

Pathways for CD81 Gene

genes like me logo Genes that share pathways with CD81: view

Pathways by source for CD81 Gene

1 Qiagen pathway for CD81 Gene
1 BioSystems pathway for CD81 Gene
3 KEGG pathways for CD81 Gene
1 GeneGo (Thomson Reuters) pathway for CD81 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 14676841
GO:0006661 phosphatidylinositol biosynthetic process IDA 14676841
GO:0008104 protein localization IDA 14676841
GO:0008283 cell proliferation TAS 1695320
GO:0008284 positive regulation of cell proliferation IDA 14676841
genes like me logo Genes that share ontologies with CD81: view

Compounds for CD81 Gene

(10) Novoseek inferred chemical compound relationships for CD81 Gene

Compound -log(P) Hits PubMed IDs
ribavirin 45.6 6
digitonin 41.1 6
ganglioside 22.3 2
tyrosine 5.56 2
calcium 2.64 1
genes like me logo Genes that share compounds with CD81: view

Transcripts for CD81 Gene

Unigene Clusters for CD81 Gene

CD81 molecule:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD81

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD81 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - -
SP10: -
SP11: - - - - - - - - - -
SP12: -

Relevant External Links for CD81 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD81 Gene

mRNA expression in normal human tissues for CD81 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CD81 Gene

This gene is overexpressed in Frontal cortex (7.5) and Spinal cord (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD81 Gene

SOURCE GeneReport for Unigene cluster for CD81 Gene Hs.54457

mRNA Expression by UniProt/SwissProt for CD81 Gene

Tissue specificity: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines
genes like me logo Genes that share expressions with CD81: view

Expression partners for CD81 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CD81 Gene

Orthologs for CD81 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD81 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD81 35
  • 90.68 (n)
  • 94.49 (a)
CD81 36
  • 94 (a)
(Canis familiaris)
Mammalia LOC611606 35
  • 90.67 (n)
  • 95.41 (a)
CD81 36
  • 90 (a)
(Mus musculus)
Mammalia Cd81 35
  • 86.72 (n)
  • 91.95 (a)
Cd81 16
Cd81 36
  • 92 (a)
(Pan troglodytes)
Mammalia CD81 35
  • 99.29 (n)
  • 100 (a)
CD81 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cd81 35
  • 87.01 (n)
  • 93.22 (a)
(Gallus gallus)
Aves CD81 35
  • 78.32 (n)
  • 80.37 (a)
TAPA1 36
  • 83 (a)
(Anolis carolinensis)
Reptilia CD81 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd81 35
  • 70.5 (n)
  • 71.91 (a)
MGC75667 35
African clawed frog
(Xenopus laevis)
Amphibia cd81-prov 35
(Danio rerio)
Actinopterygii cd81 35
  • 67.53 (n)
  • 65.95 (a)
cd81 36
  • 65 (a)
CD81 (1 of 2) 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000823 35
  • 52.36 (n)
  • 34.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp96F 35
  • 47.58 (n)
  • 31.28 (a)
Tsp96F 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea tsp-9 36
  • 26 (a)
Species with no ortholog for CD81:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD81 Gene

Gene Tree for CD81 (if available)
Gene Tree for CD81 (if available)

Paralogs for CD81 Gene

Paralogs for CD81 Gene

genes like me logo Genes that share paralogs with CD81: view

Variants for CD81 Gene

Sequence variations from dbSNP and Humsavar for CD81 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10645 -- 2,396,906(+) TGCCC(C/G)CTAAG utr-variant-3-prime
rs14077 -- 2,396,663(+) TTCTC(C/T)GGGAA reference, synonymous-codon
rs708564 -- 2,388,869(+) GGAGT(C/T)GGATG intron-variant
rs731909 -- 2,387,394(+) CAAAA(C/G)AAAAT intron-variant
rs800128 -- 2,383,847(+) GTAAG(A/G)TATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD81 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV Gain 19166990
nsv896806 CNV Loss 21882294
nsv469928 CNV Loss 18288195
nsv896808 CNV Loss 21882294
dgv1000n71 CNV Loss 21882294
nsv896811 CNV Loss 21882294
nsv896812 CNV Loss 21882294
nsv896816 CNV Loss 21882294
nsv509382 CNV Insertion 20534489
nsv896820 CNV Loss 21882294
nsv896821 CNV Loss 21882294
esv1007864 CNV Deletion 20482838
esv2744006 CNV Deletion 23290073
esv1285833 CNV Deletion 17803354

Relevant External Links for CD81 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD81 Gene

Disorders for CD81 Gene

(1) OMIM Diseases for CD81 Gene (186845)


  • Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:20237408}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for CD81 Gene

(17) Novoseek inferred disease relationships for CD81 Gene

Disease -log(P) Hits PubMed IDs
hepatitis c 78.9 53
hepatitis c chronic 57.3 9
virus infection 47 16
hepatocellular carcinoma 31.6 5
lymphoproliferative disorders 21.8 2

Relevant External Links for CD81

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD81: view

No data available for Genatlas for CD81 Gene

Publications for CD81 Gene

  1. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. (PMID: 1695320) Oren R. … Levy S. (Mol. Cell. Biol. 1990) 3 4 23
  2. Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. (PMID: 12437138) Kitadokoro K. … Bolognesi M. (Biol. Chem. 2002) 3 4 23
  3. Structural characterization of peptide fragments from hCD81-LEL. (PMID: 12492902) Dhanasekaran M. … Prakash O. (J. Pept. Res. 2003) 3 23
  4. In vitro binding of hepatitis C virus to CD81-positive and -negative human cell lines. (PMID: 12519228) Sasaki M. … Hayashi N. (J. Gastroenterol. Hepatol. 2003) 3 23
  5. Tetraspanin CD81 provides a costimulatory signal resulting in increased human immunodeficiency virus type 1 gene expression in primary CD4+ T lymphocytes through NF-kappaB, NFAT, and AP-1 transduction pathways. (PMID: 15767432) Tardif M.R. … Tremblay M.J. (J. Virol. 2005) 3 23

Products for CD81 Gene

  • Addgene plasmids for CD81

Sources for CD81 Gene

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