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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD81 Gene

protein-coding   GIFtS: 65
GCID: GC11P002397

CD81 Molecule

(Previous name: CD81 antigen (target of antiproliferative antibody 1))
(Previous symbol: TAPA1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD81 Molecule1 2     S5.72
TAPA11 2 3 5     tetraspanin-282
CD81 Antigen (Target Of Antiproliferative Antibody 1)1 2     tspan-282
26 KDa Cell Surface Protein TAPA-12 3     Tetraspanin-283
TSPAN282 3     Tspan-283
CD81 Antigen2 3     Target Of The Antiproliferative Antibody 13
CVID62 5     

External Ids:    HGNC: 17011   Entrez Gene: 9752   Ensembl: ENSG000001106517   OMIM: 1868455   UniProtKB: P600333   

Export aliases for CD81 gene to outside databases

Previous GC identifers: GC11P002460 GC11P002599 GC11P002356 GC11P002363 GC11P002355 GC11P002188


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD81 Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known
to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance.
Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and
thus it is a candidate gene for malignancies. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD81 Gene: 
CD81 (CD81 molecule) is a protein-coding gene. Diseases associated with CD81 include immunodeficiency, common variable, 6, and hepatitic c virus, and among its related super-pathways are Immune System and Immune response Fc epsilon RI pathway. GO annotations related to this gene include protein binding. An important paralog of this gene is TSPAN2.

UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
Function: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13
protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV

Gene Wiki entry for CD81 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD81 gene promoter:
         STAT1   MAZR   Pax-5   Brachyury   STAT1beta   Lmo2   STAT1alpha   Gfi-1   ZIC2/Zic2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD81 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD81

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD81


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

CD81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD81 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P002397:  view genomic region     (about GC identifiers)

Start:
2,397,407 bp from pter      End:
2,418,649 bp from pter
Size:
21,243 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD81_HUMAN, P60033 (See protein sequence)
Recommended Name: CD81 antigen  
Size: 236 amino acids; 25809 Da
Subunit: Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins
heterodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP. Interacts with IFITM1, IFITM2 and
IFITM3. Part of a GPCR-tetraspanin complex consisting at least of GPR56, CD81, eventually CD9, and GNA11 in which
CD81 is enhancing the association of GPR56 with GNA11
Subcellular location: Membrane; Multi-pass membrane protein
3 PDB 3D structures from and Proteopedia for CD81:
1G8Q (3D)        1IV5 (3D)        2AVZ (3D)    
Secondary accessions: P18582 Q5U0J6

Explore the universe of human proteins at neXtProt for CD81: NX_P60033

Explore proteomics data for CD81 at MOPED 

Post-translational modifications:

  • UniProtKB: Not glycosylated (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P60033

  • CD81 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD81 Protein Expression
    REFSEQ proteins: NP_004347.1  
    ENSEMBL proteins: 
     ENSP00000433178   ENSP00000432723   ENSP00000263645   ENSP00000435633   ENSP00000437242  
     ENSP00000433767   ENSP00000433904   ENSP00000432497   ENSP00000370424   ENSP00000432249  
     ENSP00000431780   ENSP00000432033  
    Reactome Protein details: P60033
    Human Recombinant Protein Products for CD81: 
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    Novus Biologicals CD81 Proteins
    Novus Biologicals CD81 Lysate
    Sino Biological Recombinant Protein for CD81
    Sino Biological Cell Lysate for CD81 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA14676841
    GO:0016021integral to membrane ----

    CD81 for ontologies           About GeneDecksing



    CD81 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CD81 

    Assay Products for CD81: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD81
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P60033

    ProtoNet protein and cluster: P60033

    UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
    Similarity: Belongs to the tetraspanin (TM4SF) family


    CD81 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD81_HUMAN, P60033
    Function: May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13
    protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV

         Genatlas biochemistry entry for CD81:
    integral membrane protein (26kDa),associated with CD19,B cell surface molecule,expressed on many cell types,target
    of an antiproliferative antibody

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10400713
    GO:0023026MHC class II protein complex binding IDA--
         
    CD81 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CD81:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd81):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  nervous system  respiratory system  skeleton 

    CD81 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD81: Cd81tm1Lvy Cd81tm1Tmiy Cd81tm1Geha

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD81 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD81

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD81 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD81 

    miRNA
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    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-1237 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidCD81 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CD81 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD81


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD81 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Immune response Fc epsilon RI pathway
    Immune response BCR pathway0.45
    3B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    4ErbB4 Pathway
    PI3K Signaling in B-Lymphocyte0.35
    5Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CD81
        Immune response BCR pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CD81
        PI3K Signaling in B-Lymphocyte

    1 GeneGo (Thomson Reuters) Pathway for CD81
        Immune response BCR pathway

    1 BioSystems Pathway for CD81
        B Cell Receptor Signaling Pathway


    3        Reactome Pathways for CD81
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    3         Kegg Pathways  (Kegg details for CD81):
        B cell receptor signaling pathway
    Malaria
    Hepatitis C


    CD81 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD81

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for CD81 (P600332, 3 ENSP000002636454) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD19P153912, 3, ENSP000003134194MINT-8407185 I2D: score=3 STRING: ENSP00000313419
    IGSF8Q969P02, 3, ENSP000003166644MINT-8407185 I2D: score=2 STRING: ENSP00000316664
    PTGFRNQ9P2B22, 3, ENSP000003768994MINT-8407185 I2D: score=2 STRING: ENSP00000376899
    CD63P089622, 3, ENSP000002578574MINT-8407185 I2D: score=1 STRING: ENSP00000257857
    ZBTB16Q055162, 3MINT-63913 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA14676841
    GO:0006661phosphatidylinositol biosynthetic process IDA14676841
    GO:0008104protein localization IDA14676841
    GO:0008283cell proliferation TAS1695320
    GO:0008284positive regulation of cell proliferation IDA14676841

    CD81 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD81 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD81

    10 Novoseek inferred chemical compound relationships for CD81 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ribavirin 45.6 7 11391542 (3), 19780859 (1), 16735696 (1), 16623441 (1)
    digitonin 41.1 6 9804823 (3), 10229664 (2), 12938224 (1)
    ganglioside 22.3 3 15248289 (1), 15710618 (1)
    tyrosine 5.56 2 12645944 (1), 8683154 (1)
    calcium 2.64 1 12645944 (1)
    cholesterol 0 6 15004227 (1), 12938224 (1), 19476617 (1)
    lipid 0 3 12645944 (1), 11113129 (1)
    phosphatidylinositol 0 3 9006891 (2), 11113129 (1)
    polysaccharide 0 2 10623732 (1), 17507469 (1)
    cysteine 0 3 14966136 (1), 19328198 (1)

    Search CenterWatch for drugs/clinical trials and news about CD81

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD81 gene: 
    NM_004356.3  

    Unigene Cluster for CD81:

    CD81 molecule
    Hs.54457  [show with all ESTs]
    Unigene Representative Sequence: AB209380
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475945 ENST00000530648 ENST00000263645(uc001lwf.1) ENST00000533417
    ENST00000492627 ENST00000527343 ENST00000464784 ENST00000493525 ENST00000381036
    ENST00000492252 ENST00000526072 ENST00000524805 ENST00000530239 ENST00000531840
    ENST00000481687 ENST00000468153 ENST00000481386
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CD81 (see all 14):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-1237 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidCD81 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209380.1 BC002978.1 BC093047.1 BT019507.1 BT019508.1 M33680.1 

    24/29 DOTS entries (see all 29):

    DT.92453568  DT.100885968  DT.100040647  DT.451059  DT.97864485  DT.95157455  DT.451056  DT.91689119 
    DT.91978911  DT.120734561  DT.100769546  DT.100885965  DT.95157374  DT.100885949  DT.100885952  DT.120734601 
    DT.101985222  DT.120734607  DT.121632864  DT.97856641  DT.100885951  DT.100885953  DT.120734553  DT.120734571 

    24/858 AceView cDNA sequences (see all 858):

    CR598692 BQ883552 BU751874 BE874004 BC002978 BU848835 BM981166 CR601869 
    CR604916 BM687979 AA369442 CB134870 BQ681072 BQ008787 BI759896 BM672442 
    AI418809 BM995027 BM472582 BM988331 BG674510 CA426345 BM990299 CA434584 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CD81 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
    SP1:                    -     -     -     -     -     -     -           -     -           -           -                                       
    SP2:                                      -     -     -     -           -     -           -           -                                       
    SP3:                                -     -     -     -     -           -     -           -           -                                       
    SP4:                                                                    -     -           -           -                                       
    SP5:                                            -     -     -           -     -           -           -                                       


    ECgene alternative splicing isoforms for CD81

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD81 expression in normal human tissues (normalized intensities)      CD81 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD81 Expression
    About this image


    CD81 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, pre-menopause ; cells in endometrial stroma   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   

    See CD81 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD81

    SOURCE GeneReport for Unigene cluster: Hs.54457

    UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
    Tissue specificity: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including CD81: 
              T-cell & B-cell Activation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CD81 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd811 , 5 CD81 antigen1, 5 86.72(n)1
    91.95(a)1
      7 (88.10 cM)5
    125201  NM_133655.21  NP_598416.11 
     1430527395 
    chicken
    (Gallus gallus)
    Aves CD811 CD81 molecule 78.12(n)
    80.37(a)
      374256  NM_001030339.1  NP_001025510.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD816
    Uncharacterized protein
    75(a)
    1 ↔ 1
    1(69531278-69543934)
    African clawed frog
    (Xenopus laevis)
    Amphibia cd81-prov2 CD81 antigen (target of antiproliferative antibody more 79.41(n)    BC041217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cd812 CD81 antigen 79.43(n)   58031  AF295377.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp96F1 Tetraspanin 96F 47.79(n)
    31.42(a)
      43127  NM_079776.2  NP_524500.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-96
    tsp-86
    Protein TSP-8
    24(a)
    22(a)
    possible ortholog
    1 ↔ many
    X(1246017-1247499)
    X(14726626-14729482)


    ENSEMBL Gene Tree for CD81 (if available)
    TreeFam Gene Tree for CD81 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD81 gene
    TSPAN22  CD92  TSPAN82  
    10 SIMAP similar genes for CD81 using alignment to 11 protein entries:     CD81_HUMAN (see all proteins):
    BTCC-1    CD9    CD82    TSPAN2    TSPAN8    TSPAN5
    TSPAN11    TSPAN4    CD53    TSPAN9

    CD81 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/569 SNPs in CD81 are shown (see all 569)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876705661,2
    --2396554(+) TCCCCA/GGCTCT 1 -- us2k10--------
    rs1142602761,2
    C,F--2396661(+) GCCCCA/GACCCT 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs7081541,2
    C,F,A,H--2396666(+) AACCCC/TGTGAC 1 -- us2k125Minor allele frequency- T:0.21NS EA NA WA CSA 2349
    rs1156436861,2
    C,F--2396726(+) CCATCG/ATGCTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1400994911,2
    --2396749(+) TCTCCA/GCCAGA 1 -- us2k10--------
    rs788526671,2
    C--2396765(+) AGATCC/TTCCAG 1 -- us2k10--------
    rs1908640761,2
    --2396783(+) GTCTGC/TTGCCT 1 -- us2k10--------
    rs1808844741,2
    --2396898(+) CATGGC/TCTGCT 1 -- us2k10--------
    rs1433734201,2
    --2396927(+) GGACAC/TAGTGT 1 -- us2k10--------
    rs1172379551,2
    F--2396955(+) CCTCCC/TACTTC 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for CD81 (2397407 - 2418649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for CD81 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1007864CNV Deletion20482838
    esv1285833CNV Deletion17803354
    esv2744006CNV Deletion23290073
    nsv509382CNV Insertion20534489
    nsv896812CNV Loss21882294
    nsv469928CNV Loss18288195
    nsv896806CNV Loss21882294
    dgv1000n71CNV Loss21882294
    nsv896816CNV Loss21882294
    nsv896811CNV Loss21882294


    Human Gene Mutation Database (HGMD): CD81
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CD81

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 186845   
    OMIM disorders: 613496  
    UniProtKB/Swiss-Prot: CD81_HUMAN, P60033
  • Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by
    antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody
    response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of
    immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 20/28 diseases for CD81 (see all 28):    About MalaCards
    immunodeficiency, common variable, 6    hepatitic c virus    mixed cryoglobulinemia    cryoglobulinemia
    hepatitis c    dengue hemorrhagic fever    hemorrhagic fever    malaria
    hepatitis    hepatitis b    hepatocellular carcinoma    multiple myeloma
    acute lymphoblastic leukemia    myeloma    lymphoblastic leukemia    chronic lymphocytic leukemia
    liver disease    glioblastoma    neuroblastoma    leukemia

    4 diseases from the University of Copenhagen DISEASES database for CD81:
    Hepatitis C     Cryoglobulinemia     Liver disease     Hepatocellular carcinoma

    CD81 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/17 Novoseek inferred disease relationships for CD81 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis c 78.9 56 12645944 (2), 14722300 (2), 19489072 (2), 11024134 (2) (see all 45)
    hepatitis c chronic 57.3 9 11130883 (2), 16735696 (2), 16623441 (1), 11391542 (1) (see all 7)
    virus infection 47 17 11985527 (2), 14722300 (1), 11602742 (1), 20512986 (1) (see all 15)
    hepatocellular carcinoma 31.6 6 11115611 (2), 12210407 (1), 11130883 (1), 16819966 (1)
    lymphoproliferative disorders 21.8 2 17177963 (1), 12558906 (1)
    metastasis 14.1 8 15698400 (2), 11115611 (2), 18466772 (1), 9597125 (1)
    immunodeficiency 9.99 2 17177963 (1), 15767432 (1)
    lymphoma b-cell 9.45 6 20004001 (3)
    hepatitis 1.25 1 11130883 (1)
    necrosis 0 2 8668914 (1), 18805782 (1)

    Genetic Association Database (GAD): CD81
    Human Genome Epidemiology (HuGE) Navigator: CD81 (15 documents)

    Export disorders for CD81 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD81 gene, integrated from 9 sources (see all 332):
    (articles sorted by number of sources associating them with CD81)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. (PubMed id 1695320)1, 2, 9 Oren R.... Levy S. (1990)
    2. Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. (PubMed id 12437138)1, 2, 9 Kitadokoro K.... Bolognesi M. (2002)
    3. Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor. (PubMed id 12913001)1, 2, 9 Bartosch B.... Cosset F.-L. (2003)
    4. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)
    5. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    6. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    7. CD81 gene defect in humans disrupts CD19 complex form ation and leads to antibody deficiency. (PubMed id 20237408)1, 2 van Zelm M.C....van der Burg M. (2010)
    8. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    9. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    10. Common genetic variants in candidate genes and risk o f familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 975 HGNC: 1701 AceView: CD81 Ensembl:ENSG00000110651 euGenes: HUgn975
    ECgene: CD81 Kegg: 975 H-InvDB: CD81

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD81 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD81 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD81 gene:
    Search GeneIP for patents involving CD81

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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