Aliases for CD80 Gene
Aliases for CD80 Gene
External Ids for CD80 Gene
- HGNC: 1700
- Entrez Gene: 941
- Ensembl: ENSG00000121594
- OMIM: 112203
- UniProtKB: P33681
Previous HGNC Symbols for CD80 Gene
- CD28LG
- CD28LG1
Previous GeneCards Identifiers for CD80 Gene
- GC03M115885
- GC03M118875
- GC03M120524
- GC03M120564
- GC03M120725
- GC03M119243
- GC03M116618
Summaries for CD80 Gene
-
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD80 Gene
CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Vaccinia and Systemic Lupus Erythematosus. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.
UniProtKB/Swiss-Prot for CD80 Gene
-
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
-
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD80 Gene
Genomics for CD80 Gene
Regulatory Elements for CD80 Gene
- Transcription factor binding sites by QIAGEN in the CD80 gene promoter:
Regulatory Element Products
Genomic Location for CD80 Gene
- Chromosome:
- 3
- Start:
- 119,523,948 bp from pter
- End:
- 119,559,634 bp from pter
- Size:
- 35,687 bases
- Orientation:
- Minus strand
Genomic View for CD80 Gene
- Cytogenetic band:
-
- 3q13.33 by Ensembl
- 3q13.33 by Entrez Gene
- 3q13.33 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD80 Gene
Proteins for CD80 Gene
-
Protein details for CD80 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P33681-CD80_HUMAN
- Recommended name:
- T-lymphocyte activation antigen CD80
- Protein Accession:
- P33681
- Q5DTA9
- Q5DTB0
Protein attributes for CD80 Gene
- Size:
- 288 amino acids
- Molecular mass:
- 33048 Da
- Quaternary structure:
-
- Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement.
- (Microbial infection) Interacts with adenovirus subgroup B fiber proteins.
Post-translational modifications for CD80 Gene
Other Protein References for CD80 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD80 (B7-1/CD80)
-
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- AM05201PU-N
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- TA600491
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- TA700490
- UM500055
- UM570055
- TA501576S
- Novus Biologicals Antibodies for CD80
- Invitrogen Antibodies for CD80
- antibodies-online Antibodies for CD80: See all 669
- GeneTex CD80 antibody for CD80
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD80
Protein Products
- R&D Systems Proteins and Enzymes for CD80 (B7-1/CD80)
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-
OriGene Purified Proteins for CD80
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- Sino Biological Recombinant Proteins for CD80
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- antibodies-online Proteins for CD80: See all 32
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Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CD80
- R&D Systems ELISAs and other biochemical assays for CD80 (B7-1/CD80)
- eBioscience Human sCD80 Instant ELISA 128 tests for CD80
- antibodies-online Kits for CD80: See all 28
-
Abcam assays for CD80
No data available for DME Specific Peptides for CD80 Gene
Domains & Families for CD80 Gene
Gene Families for CD80 Gene
Protein Domains for CD80 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD80 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD80 Gene
Function for CD80 Gene
Molecular function for CD80 Gene
- GENATLAS Biochemistry:
- cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand
- UniProtKB/Swiss-Prot Function:
- Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for adenovirus subgroup B.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001618 | virus receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 9915850 |
| GO:0015026 | coreceptor activity | NAS | 9915850 |
| GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | TAS | -- |
Phenotypes for CD80 Gene
- MGI mutant phenotypes for CD80:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CD80:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased viability of wild-type and TP53 knockout cells
Animal Model Products
-
Taconic Biosciences Mouse Models for CD80
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD80
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CD80 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
- Search ViGene Biosciences for CD80
CRISPR Products
-
OriGene CRISPR knockouts for CD80
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD80
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miRNA Products
- Search ViGene Biosciences for CD80
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CD80
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-
ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
Clone Products
- Sino Biological Human cDNA Clone for CD80
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD80
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD80
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CD80 (B7-1/CD80)
Cell Line Products
-
Horizon Cell Lines for CD80
-
ViGene Biosciences adenoviral particle packaged cDNA for CD80 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD80 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10270 ) for CD80
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD80 Gene
Localization for CD80 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD80 Gene
- Membrane; Single-pass type I membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IDA | 23981064 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for CD80 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | RET signaling |
.92
|
|
| 3 | GAB1 signalosome |
.89
|
|
| 4 | Allograft rejection | ||
| 5 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
Pathways by source for CD80 Gene
7 BioSystems pathways for CD80 Gene
33 Reactome pathways for CD80 Gene
3 GeneGo (Thomson Reuters) pathways for CD80 Gene
6 R&D Systems pathways for CD80 Gene
34 Qiagen pathways for CD80 Gene
Interacting Proteins for CD80 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007267 | cell-cell signaling | IC | 9915850 |
| GO:0009967 | positive regulation of signal transduction | NAS | 9915850 |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | TAS | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0031295 | T cell costimulation | TAS | -- |
No data available for SIGNOR curated interactions for CD80 Gene
Drugs & Compounds for CD80 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CD80 Gene
mRNA/cDNA for CD80 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (15) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CD80
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD80
- GenScript: Design CRISPR guide RNA sequences for CD80
miRNA Products
- Search ViGene Biosciences for CD80
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CD80
- Browse OriGene Inhibitory RNA Products For CD80
-
ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
Clone Products
- Sino Biological Human cDNA Clone for CD80
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD80
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD80
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CD80 (B7-1/CD80)
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10270 ) for CD80
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||
| SP5: |
Expression for CD80 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
- Blood (Hematopoietic System)
- Inner Cell Mass (Early Embryonic Tissues)
NURSA nuclear receptor signaling pathways regulating expression of CD80 Gene:
CD80SOURCE GeneReport for Unigene cluster for CD80 Gene:
Hs.838mRNA Expression by UniProt/SwissProt for CD80 Gene:
P33681-CD80_HUMANEvidence on tissue expression from TISSUES for CD80 Gene
- Nervous system(4.3)
- Spleen(3.8)
- Lymph node(3.6)
- Blood(3.5)
- Bone marrow(2.6)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for CD80
-
OriGene qPCR primer pairs for CD80
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD80 Gene
Orthologs for CD80 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD80 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CD80 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CD80 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cd80 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd80 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CD80 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CD80 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CD80 35 |
|
OneToOne |
- Species where no ortholog for CD80 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CD80 Gene
Variants for CD80 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000213010 | -- | 119,545,406(+) | TACAG(G/T)TCAGT | intron-variant | |
| rs1000244113 | -- | 119,543,558(+) | TTCAA(A/G)TGATT | intron-variant | |
| rs1000533706 | -- | 119,529,740(+) | TAAAC(A/G)TGAGA | intron-variant | |
| rs1000679202 | -- | 119,539,635(+) | GTACA(C/G)GAAAA | intron-variant | |
| rs1000881304 | -- | 119,556,523(+) | TAAAA(A/C)ACCTG | intron-variant, utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3353419 | CNV | insertion | 20981092 |
| nsv829695 | CNV | loss | 17160897 |
Relevant External Links for CD80 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CD80
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD80 Gene
Disorders for CD80 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vaccinia |
|
|
| systemic lupus erythematosus |
|
|
| follicular lymphoma |
|
|
| fungal esophagitis |
|
|
| wegener granulomatosis |
|
Relevant External Links for CD80
No data available for UniProtKB/Swiss-Prot and Genatlas for CD80 Gene
Publications for CD80 Gene
- Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T. … Mishima M. (Respiration 2005) 3 22 46 64
- New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PMID: 11196673) Matsushita M. … Tokunaga K. (Genes Immun. 2000) 3 22 46 64
- Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PMID: 1377173) Selvakumar A. … Dupont B. (Immunogenetics 1992) 3 4 22 64
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
- PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (PMID: 20066438) Ishizaki Y. … Hara T. (Hum. Genet. 2010) 3 46 64
Products for CD80 Gene
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- Browse Primary Antibodies
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- AM05201PU-N
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- UM500055
- UM570055
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- Custom Assay ServicesOriGene ELISA Kits for CD80
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- Search Origene for MassSpec and Protein Over-expression Lysates for CD80
- Origene Custom Protein Services for CD80
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- OriGene qPCR primer pairs and template standards for CD80
- OriGene qPCR primer pairs for CD80
- OriGene CRISPR knockouts for CD80
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- Sino Biological Antibodies
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- Novus Biologicals Antibodies for CD80
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- Novus Biologicals
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- Taconic Biosciences Mouse Models for CD80
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Search eBioscience for CD80 related proteins
- eBioscience Human sCD80 Instant ELISA 128 tests for CD80
- eBioscience FlowRNA Probe Sets (VA1-10270 ) for CD80
- antibodies-online Antibodies for CD80: See all 669
- antibodies-online Kits for CD80: See all 28
- antibodies-online Proteins for CD80: See all 32
- Search antibodies-online for peptides
- GeneTex CD80 antibody for CD80
- Search GeneTex for Proteins for CD80
- ViGene Biosciences adenoviral particle packaged cDNA for CD80 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
- Search ViGene Biosciences for CD80
- Santa Cruz Biotechnology (SCBT) Antibodies for CD80
- Search Santa Cruz Biotechnology (SCBT) for CD80 siRNA/shRNA
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- Horizon Cell Lines for CD80
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD80
- VectorBuilder custom plasmid, inducible vectors for CD80
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD80
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CD80 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
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