Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD80 Gene

protein-coding   GIFtS: 63
GCID: GC03M119243

CD80 Molecule

(Previous names: CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD8...)
(Previous symbols: CD28LG, CD28LG1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD80 Molecule1 2     BB12 3
CD28LG1 2 3 5     CTLA-4 Counter-Receptor B7.12 3
CD28LG11 2 3     B7-12
LAB72 3 5     B7.12
CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen)1 2     Costimulatory Factor CD802
B-Lymphocyte Activation Antigen B71 2     Costimulatory Molecule Variant IgV-CD802
Activation B7-1 Antigen2 3     T-Lymphocyte Activation Antigen CD802
B72 3     CD80 Antigen3

External Ids:    HGNC: 17001   Entrez Gene: 9412   Ensembl: ENSG000001215947   OMIM: 1122035   UniProtKB: P336813   

Export aliases for CD80 gene to outside databases

Previous GC identifers: GC03M115885 GC03M118875 GC03M120524 GC03M120564 GC03M120725 GC03M116618


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD80 Gene:
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The
activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for
adenovirus subgroup B and may play a role in lupus neuropathy. (provided by RefSeq, Aug 2011)

GeneCards Summary for CD80 Gene: 
CD80 (CD80 molecule) is a protein-coding gene. Diseases associated with CD80 include sialadenitis, and wegener's granulomatosis, and among its related super-pathways are Costimulation by the CD28 family and Toll-like receptor signaling pathway. GO annotations related to this gene include protein binding and coreceptor activity. An important paralog of this gene is CD86.

UniProtKB/Swiss-Prot: CD80_HUMAN, P33681
Function: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and
cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor

Gene Wiki entry for CD80 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD80 gene promoter:
         ISGF-3   STAT1   AP-1   ATF-2   NF-kappaB   AREB6   NF-kappaB2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD80 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD80

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD80


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.3-q21   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.3-q21

CD80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD80 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M119243:  view genomic region     (about GC identifiers)

Start:
119,243,140 bp from pter      End:
119,278,481 bp from pter
Size:
35,342 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD80_HUMAN, P33681 (See protein sequence)
Recommended Name: T-lymphocyte activation antigen CD80 precursor  
Size: 288 amino acids; 33048 Da
Subunit: Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses
Subcellular location: Membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for CD80:
1DR9 (3D)        1I8L (3D)    

Explore the universe of human proteins at neXtProt for CD80: NX_P33681

Explore proteomics data for CD80 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P33681

  • CD80 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD80 Protein Expression
    REFSEQ proteins: NP_005182.1  
    ENSEMBL proteins: 
     ENSP00000264246   ENSP00000418364   ENSP00000373165   ENSP00000373164  
    Reactome Protein details: P33681
    Human Recombinant Protein Products for CD80: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD80 (B7-1/CD80)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD80
    OriGene Protein Over-expression Lysate for CD80
    OriGene MassSpec for CD80 
    OriGene Custom Protein Services for CD80
    GenScript Custom Purified and Recombinant Proteins Services for CD80
    Novus Biologicals CD80 Proteins
    Novus Biologicals CD80 Lysates
    Sino Biological Recombinant Protein for CD80
    Sino Biological Cell Lysate for CD80 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane IC9915850

    CD80 for ontologies           About GeneDecksing



    CD80 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD80 (B7-1/CD80)
    OriGene Antibodies for CD80
    OriGene Custom Antibody Services for CD80
    GenScript Custom Superior Antibodies Services for CD80
    Novus Biologicals CD80 Antibodies
    Abcam antibodies for CD80
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CD80
    LSBio Antibodies in human, mouse, rat for CD80 

    Assay Products for CD80: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD80
    R&D Systems ELISAs for CD80 (B7-1/CD80)
    GenScript Custom Assay Services for CD80
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P33681

    ProtoNet protein and cluster: P33681

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: CD80_HUMAN, P33681
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD80 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD80_HUMAN, P33681
    Function: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and
    cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor

         Genatlas biochemistry entry for CD80:
    cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86
    ligand

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11279502
    GO:0015026coreceptor activity NAS9915850
         
    CD80 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD80:
     Decreased viability of wild-ty  Synthetic lethal with c-Myc af 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd80):
     cellular  endocrine/exocrine gland  hematopoietic system  immune system  nervous system 

    CD80 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD80: Cd80tm1Lbgn Cd80tm1Shr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD80 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD80

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD80 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD80 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD80
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CD80 (see all 11):
    hsa-miR-146a hsa-miR-323b-3p hsa-miR-455-3p hsa-miR-3125 hsa-miR-3916 hsa-miR-138-1* hsa-miR-3649 hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmidCD80 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD80
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD80

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD80
    Sirion Biotech Customized adenovirus for overexpression of CD80

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD80 (see all 7)
    OriGene ORF clones in mouse, rat for CD80
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD80 (NM_005191)
    Sino Biological Human cDNA Clone for CD80
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD80
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD80
    Sirion Biotech Customized lentivirus for stable overexpression of CD80 
                         Customized lentivirus expression plasmids for stable overexpression of CD80 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD80
    Search LifeMap BioReagents cell lines for CD80
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD80


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD80 About   (see all 31)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CD28 co-stimulation
    CD28 co-stimulation0.66
    CD28 dependent Vav1 pathway0.38
    CD28 dependent PI3K/Akt signaling0.66
    CTLA4 Signaling0.31
    Costimulation by the CD28 family0.41
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    3Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    4PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    5PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI-3K cascade0.88
    Signaling by SCF-KIT0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CD80
        Immune response CD28 signaling
    Immune response NFAT in immune response
    Immune response ICOS pathway in T-helper cell

    2 R&D Systems Pathways for CD80
        Th1 Differentiation
    Th17 Differentiation

    5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD80 (see all 34)
        Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    JNK Pathway
    Tec Kinases Signaling
    Rho Family GTPases

    3 GeneGo (Thomson Reuters) Pathways for CD80
        Immune response ICOS pathway in T-helper cell
    Immune response CD28 signaling
    Immune response NFAT in immune response

    4 BioSystems Pathways for CD80
        Toll-like receptor signaling pathway
    TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells
    Inflammatory Response Pathway


    5/36        Reactome Pathways for CD80 (see all 36)
        CD28 dependent Vav1 pathway
    Costimulation by the CD28 family
    Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction


    5/10         Kegg Pathways  (Kegg details for CD80) (see all 10):
        Cell adhesion molecules (CAMs)
    Toll-like receptor signaling pathway
    Intestinal immune network for IgA production
    Type I diabetes mellitus
    Autoimmune thyroid disease


    CD80 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD80

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for CD80 (P336811, 3 ENSP000002642464) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTLA4P164101, 3, ENSP000003039394EBI-1031024,EBI-1030991 I2D: score=4 STRING: ENSP00000303939
    CD28P107473, ENSP000003248904I2D: score=3 STRING: ENSP00000324890
    CD86P420813, ENSP000003320494I2D: score=1 STRING: ENSP00000332049
    CD274Q9NZQ71, ENSP000003709894EBI-1031024,EBI-4314282 STRING: ENSP00000370989
    NGFRP081381, ENSP000001722294EBI-1031024,EBI-1387782 STRING: ENSP00000172229
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling IC9915850
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0009967positive regulation of signal transduction NAS9915850
    GO:0019048modulation by virus of host morphology or physiology IEA--

    CD80 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD80 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD80

    2 DrugBank Compounds for CD80    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AbataceptBMS-188667 (see all 9)332348-12-6targetantagonist18041889 16357751 16932686 17020493 16573350 11752352 20080922 17212998 16971318
    BelataceptBMS-224818 (see all 2)706808-37-9target--17616278 16978033

    10/27 Novoseek inferred chemical compound relationships for CD80 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ctla4-ig 76.9 21 8228824 (2), 1385153 (2), 7515331 (2), 7545666 (2) (see all 11)
    tn 1000 53 1 17156728 (1)
    ct-26 25.9 2 16489051 (2)
    ionomycin 24.2 2 9780158 (2)
    cyclosporin a 20.8 4 16237117 (1), 18652845 (1), 1380533 (1)
    2-methoxyethanol 10.7 3 10459548 (2), 10477744 (1)
    rituximab 10.4 1 17456057 (1)
    allergens 4.6 1 15049782 (1)
    1-chloro-24-dinitrobenzene 3.18 3 12650676 (1), 17118622 (1)
    nitric oxide 1.82 4 10075022 (1), 19555217 (1)

    Search CenterWatch for drugs/clinical trials and news about CD80

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD80 gene: 
    NM_005191.3  

    Unigene Cluster for CD80:

    CD80 molecule
    Hs.838  [show with all ESTs]
    Unigene Representative Sequence: BC042665
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264246(uc003ecq.3) ENST00000478182(uc010hqt.1 uc010hqu.1)
    ENST00000463729(uc003ecr.1) ENST00000383669 ENST00000383668
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD80
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CD80 (see all 11):
    hsa-miR-146a hsa-miR-323b-3p hsa-miR-455-3p hsa-miR-3125 hsa-miR-3916 hsa-miR-138-1* hsa-miR-3649 hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmidCD80 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD80
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD80
    Clone
    Products:
         
    OriGene clones in human, mouse for CD80 (see all 7)
    OriGene ORF clones in mouse, rat for CD80
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD80 (NM_005191)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD80
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD80
    Sirion Biotech Customized lentivirus for stable overexpression of CD80 
                         Customized lentivirus expression plasmids for stable overexpression of CD80 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD80
    OriGene qSTAR qPCR primer pairs in human, mouse for CD80
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD80
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD80
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD80

    Additional mRNA sequence: 

    AK292129.1 AY081815.1 AY197777.1 AY197778.1 BC042665.1 M27533.1 

    3 DOTS entries:

    DT.455212  DT.203537  DT.99998167 

    15 AceView cDNA sequences:

    AA731658 NM_005191 BC042665 CA447659 CD366279 AW105040 AV717312 AY081815 
    BF663116 AV716442 BI822963 BU943171 AW118675 AI432226 AW370828 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CD80    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
    SP1:                                      -                             -         
    SP2:                                      -                                       
    SP3:                                      -           -                           
    SP4:                                      -     -     -                           
    SP5:                                                                              


    ECgene alternative splicing isoforms for CD80

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD80 expression in normal human tissues (normalized intensities)      CD80 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCATTCT
    CD80 Expression
    About this image


    CD80 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Monocytes Peripheral Blood
             Immunosuppressive dendritic cells
             cd31+ cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells
     
     Neural Tube (Nervous System)
             Prosencephalon

    See CD80 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD80

    SOURCE GeneReport for Unigene cluster: Hs.838

    UniProtKB/Swiss-Prot: CD80_HUMAN, P33681
    Tissue specificity: Expressed on activated B-cells, macrophages and dendritic cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD80 (see all 12): 
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD80
    OriGene qSTAR qPCR primer pairs in human, mouse for CD80
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD80
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD80
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD80
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD80

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD80 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd801 , 5 CD80 antigen1, 5 63.9(n)1
    46.79(a)1
      16 (26.86 cM)5
    125191  NM_009855.21  NP_033985.31 
     384589335 
    chicken
    (Gallus gallus)
    Aves CD806
    CD80 antigen precursor
    20(a)
    1 ↔ 1
    1(91635375-91642963)
    lizard
    (Anolis carolinensis)
    Reptilia CD806
    CD80 molecule
    19(a)
    1 ↔ 1
    3(162409944-162436467)


    ENSEMBL Gene Tree for CD80 (if available)
    TreeFam Gene Tree for CD80 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD80 gene
    CD862  

    CD80 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/793 SNPs in CD80 are shown (see all 793)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384986021,2
    --119243838(+) ATAAAA/GCCATT 1 -- ut310--------
    rs1828753171,2
    --119243846(+) ATTTAA/GAGAGA 1 -- ut310--------
    rs15997951,2
    C,F,O,H--119243855(+) GATTAA/TCAGTC 1 -- ut31 ese398Minor allele frequency- N:0.00NS MN EA NA PA EU CA WA 5461
    rs1877672041,2
    --119243918(+) TTTGAC/TGTACC 1 -- ut310--------
    rs1146797261,2
    C,F--119243933(+) TCATTC/GGTCTT 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs15997961,2
    C,F,O,A,H--119243934(+) CATTCG/ATCTTA 1 -- ut31 ese3107Minor allele frequency- A:0.20EA NA NS PA EU CA WA 6762
    rs1930147531,2
    --119244023(+) ACACAA/GTGAAA 1 -- ut310--------
    rs1829005531,2
    --119244076(+) CTCCTA/CAAGAT 1 -- ut310--------
    rs1139912631,2
    C--119244138(+) TAAAA-/TCTTCTAC 1 -- cds11Minor allele frequency- TCT:0.00CSA 2
    rs1496399691,2
    --119244171(+) TAGTCC/TCTGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD80 (119243140 - 119278481 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD80:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv269361CNV Insertion20981092
    nsv829695CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD80
    DNA2.0 Custom Variant and Variant Library Synthesis for CD80

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 112203    OMIM disorders: --

    20/107 diseases for CD80 (see all 107):    About MalaCards
    sialadenitis    wegener's granulomatosis    allergic encephalomyelitis    histoplasmosis
    graves' disease    myasthenia gravis    optic neuritis    gastrointestinal system disease
    sarcoidosis    malt lymphoma    relapsing-remitting multiple sclerosis    neuritis
    polymyositis    malignant glioma    tetanus    pulmonary sarcoidosis
    encephalomyelitis    vasculitis    non-hodgkin lymphoma    multiple sclerosis

    7 diseases from the University of Copenhagen DISEASES database for CD80:
    Leukemia     Hypersensitivity reaction type II disease     Tetanus     Rheumatoid arthritis
    Lymphoma     Asthma     Melanoma

    CD80 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for CD80 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 49.9 30 7535196 (2), 11104808 (1), 15117323 (1), 19028921 (1) (see all 25)
    tumors 47.7 152 11228533 (5), 7515023 (4), 16489051 (4), 9930341 (3) (see all 83)
    tetanus 43.9 2 10084309 (1)
    autoimmune diseases 39 11 7690323 (2), 10201965 (1), 15870153 (1), 8813343 (1) (see all 8)
    lymphocytic leukemia chronic b-cell 29.3 5 9096698 (2), 11002221 (1), 9354461 (1)
    melanoma 27.2 35 7520026 (5), 12569387 (3), 10477389 (2), 7515929 (2) (see all 19)
    encephalomyelitis 26.1 2 11418697 (1), 8642061 (1)
    lymphoma follicular 25.8 2 9485189 (1), 7507734 (1)
    htlv-i infections 25.2 1 7632951 (1)
    multiple sclerosis 24.5 9 7533208 (4), 10227430 (1), 15544628 (1), 7500044 (1) (see all 5)

    Genetic Association Database (GAD): CD80
    Human Genome Epidemiology (HuGE) Navigator: CD80 (34 documents)

    Export disorders for CD80 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD80 gene, integrated from 9 sources (see all 767):
    (articles sorted by number of sources associating them with CD80)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PubMed id 15942292)1, 4, 9 Handa T....Mishima M. (2005)
    2. New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 11196673)1, 4, 9 Matsushita M....Tokunaga K. (2000)
    3. Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PubMed id 1377173)1, 2, 9 Selvakumar A....Dupont B. (1992)
    4. Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. (PubMed id 14975605)1, 4, 9 Teutsch S.M....Stewart G.J. (2004)
    5. The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21. (PubMed id 1370389)1, 3, 9 Freeman G.J....Nadler L.M. (1992)
    6. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    7. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    8. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    9. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    10. PD1 as a common candidate susceptibility gene of suba cute sclerosing panencephalitis. (PubMed id 20066438)1, 4 Ishizaki Y....Hara T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 941 HGNC: 1700 AceView: CD80 Ensembl:ENSG00000121594 euGenes: HUgn941
    ECgene: CD80 Kegg: 941 H-InvDB: CD80

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD80 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD80 gene:
    Search GeneIP for patents involving CD80

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CD80 (B7-1/CD80)   Browse Cell Culture Products  
     ELISAs for CD80 (B7-1/CD80)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CD80 (B7-1/CD80)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CD80   OriGene RNAi products in human, mouse, rat for CD80  
     OriGene qPCR primer pairs and template standards for CD80   OriGene Protein Over-expression Lysate for CD80  
     OriGene MassSpec something-or-other for CD80   OriGene clones in human, mouse for CD80  
     OriGene qSTAR qPCR primer pairs in human, mouse for CD80   OriGene Purified Protein for CD80  
     OriGene ORF clones in mouse, rat for CD80   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD80   OriGene Custom Protein Services for CD80  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD80
     QIAGEN SeqTarget long-range PCR primers for resequencing CD80
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD80
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD80
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD80
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD80
     GenScript Custom Purified and Recombinant Proteins Services for CD80 GenScript cDNA clones with any tag delivered in your preferred vector for CD80
     GenScript Custom Assay Services for CD80 GenScript Custom Superior Antibodies Services for CD80
     GenScript Custom overexpressing Cell Line Services for CD80 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CD80 promoter
     Search Chromatin IP Primers for CD80
     RT2 qPCR Primer Assay in human, mouse, rat CD80
     GNC Network for CD80
     SABiosciences PCR Arrays including human, mouse, rat CD80
     Search Tocris compounds for CD80
     Proteins and Antibodies for CD80
     Cell Lysates for CD80
     cDNA Clones for CD80
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CD80 antibodies
     CD80 proteins
     CD80 lysates
     Antibodies for CD80
     See all of Abcam's Antibodies, Kits and Proteins for CD80
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CD80
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD80
     SwitchGear 3'UTR luciferase reporter plasmids for CD80
     SwitchGear Promoter luciferase reporter plasmids for CD80
     ThermoFisher Antibodies for CD80
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD80
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CD80
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD80
    Customized:
     lentivirus for stable overexpression of CD80
     lentivirus expression plasmids for stable overexpression of CD80
     adenovirus for overexpression of CD80
     LSBio Antibodies in human, mouse, rat for CD80
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CD80 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4