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Aliases for CD80 Gene

Aliases for CD80 Gene

  • CD80 Molecule 2 3 5
  • CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen) 2 3
  • B-Lymphocyte Activation Antigen B7 2 3
  • CTLA-4 Counter-Receptor B7.1 3 4
  • Activation B7-1 Antigen 3 4
  • CD28LG1 3 4
  • CD28LG 3 4
  • LAB7 3 4
  • BB1 3 4
  • B7 3 4
  • Costimulatory Molecule Variant IgV-CD80 3
  • Costimulatory Factor CD80 3
  • CD80 Antigen 4
  • B7-1 3
  • B7.1 3

External Ids for CD80 Gene

Previous HGNC Symbols for CD80 Gene

  • CD28LG
  • CD28LG1

Previous GeneCards Identifiers for CD80 Gene

  • GC03M115885
  • GC03M118875
  • GC03M120524
  • GC03M120564
  • GC03M120725
  • GC03M119243
  • GC03M116618

Summaries for CD80 Gene

Entrez Gene Summary for CD80 Gene

  • The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD80 Gene

CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include systemic lupus erythematosus and rheumatoid arthritis. Among its related pathways are Allograft rejection and Cell adhesion molecules (CAMs). GO annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.

UniProtKB/Swiss-Prot for CD80 Gene

  • Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

  • (Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Wiki entry for CD80 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD80 Gene

Genomics for CD80 Gene

Regulatory Elements for CD80 Gene

Enhancers for CD80 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD80 on UCSC Golden Path with GeneCards custom track

Promoters for CD80 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD80 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD80 Gene

Chromosome:
3
Start:
119,523,948 bp from pter
End:
119,559,634 bp from pter
Size:
35,687 bases
Orientation:
Minus strand

Genomic View for CD80 Gene

Genes around CD80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD80 Gene

Proteins for CD80 Gene

  • Protein details for CD80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33681-CD80_HUMAN
    Recommended name:
    T-lymphocyte activation antigen CD80
    Protein Accession:
    P33681
    Secondary Accessions:
    • Q5DTA9
    • Q5DTB0

    Protein attributes for CD80 Gene

    Size:
    288 amino acids
    Molecular mass:
    33048 Da
    Quaternary structure:
    • Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement.
    • (Microbial infection) Interacts with adenovirus subgroup B fiber proteins.

    Three dimensional structures from OCA and Proteopedia for CD80 Gene

    Alternative splice isoforms for CD80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD80 Gene

Proteomics data for CD80 Gene at MOPED

Post-translational modifications for CD80 Gene

  • Glycosylation at Asn 53, Asn 89, Asn 98, Asn 186, Asn 207, Asn 211, Asn 226, and Asn 232
  • Modification sites at PhosphoSitePlus

Other Protein References for CD80 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD80 Gene

Domains & Families for CD80 Gene

Protein Domains for CD80 Gene

Graphical View of Domain Structure for InterPro Entry

P33681

UniProtKB/Swiss-Prot:

CD80_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD80: view

Function for CD80 Gene

Molecular function for CD80 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand
UniProtKB/Swiss-Prot Function:
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
genes like me logo Genes that share phenotypes with CD80: view

Animal Models for CD80 Gene

MGI Knock Outs for CD80:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD80

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD80 Gene

Localization for CD80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD80 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD80 Gene COMPARTMENTS Subcellular localization image for CD80 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
nucleus 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CD80 Gene

Pathways & Interactions for CD80 Gene

SuperPathways for CD80 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 PEDF Induced Signaling
4 Allograft rejection
5 TGF-Beta Pathway
genes like me logo Genes that share pathways with CD80: view

Gene Ontology (GO) - Biological Process for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007267 cell-cell signaling IC 9915850
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS --
GO:0031295 T cell costimulation TAS --
genes like me logo Genes that share ontologies with CD80: view

No data available for SIGNOR curated interactions for CD80 Gene

Drugs & Compounds for CD80 Gene

(22) Drugs for CD80 Gene - From: DrugBank, ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abatacept Approved Pharma binder, Target, antagonist 185
Belatacept Approved Pharma inhibitor, Target 0
Galiximab Investigational Pharma Target 0
Immunologic Factors Pharma 23243
Pharmaceutical Solutions Pharma 7317

(14) Additional Compounds for CD80 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD80: view

Transcripts for CD80 Gene

mRNA/cDNA for CD80 Gene

Unigene Clusters for CD80 Gene

CD80 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD80 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for CD80 Gene

GeneLoc Exon Structure for
CD80
ECgene alternative splicing isoforms for
CD80

Expression for CD80 Gene

mRNA expression in normal human tissues for CD80 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CD80 Gene Hs.838

mRNA Expression by UniProt/SwissProt for CD80 Gene

P33681-CD80_HUMAN
Tissue specificity: Expressed on activated B-cells, macrophages and dendritic cells.
genes like me logo Genes that share expression patterns with CD80: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CD80 Gene

Orthologs for CD80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD80 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD80 35
  • 74.85 (n)
  • 59.93 (a)
CD80 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD80 35
  • 71.53 (n)
  • 55.21 (a)
CD80 36
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd80 35
  • 65.87 (n)
  • 47.41 (a)
Cd80 16
Cd80 36
  • 39 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD80 35
  • 99.54 (n)
  • 99.31 (a)
CD80 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd80 35
  • 70.81 (n)
  • 54.84 (a)
oppossum
(Monodelphis domestica)
Mammalia CD80 36
  • 26 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD80 36
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD80 36
  • 23 (a)
OneToOne
Species with no ortholog for CD80:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD80 Gene

ENSEMBL:
Gene Tree for CD80 (if available)
TreeFam:
Gene Tree for CD80 (if available)

Paralogs for CD80 Gene

Paralogs for CD80 Gene

genes like me logo Genes that share paralogs with CD80: view

Variants for CD80 Gene

Sequence variations from dbSNP and Humsavar for CD80 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs715890 -- 119,556,546(+) TGAAA(C/T)GTAGG intron-variant, upstream-variant-2KB
rs722045 -- 119,545,747(+) ccccc(C/T)acatt intron-variant
rs1852211 -- 119,555,902(-) AACAG(C/T)CTGGA intron-variant, utr-variant-5-prime
rs1852212 -- 119,560,388(-) CTGGT(A/G)TGGGA upstream-variant-2KB
rs1880661 -- 119,560,001(-) TGGTC(C/T)TGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD80 Gene

Variant ID Type Subtype PubMed ID
nsv829695 CNV Loss 17160897
esv269361 CNV Insertion 20981092

Variation tolerance for CD80 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD80 Gene

HapMap Linkage Disequilibrium report
CD80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD80 Gene

Disorders for CD80 Gene

MalaCards: The human disease database

(16) MalaCards diseases for CD80 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • lupus nephritis
rheumatoid arthritis
  • rheumatoid arthritis, progression of
chronic lymphocytic leukemia
  • cll
ross river fever
  • ross river virus disease
fungal esophagitis
- elite association - COSMIC cancer census association via MalaCards
Search CD80 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD80

Genetic Association Database (GAD)
CD80
Human Genome Epidemiology (HuGE) Navigator
CD80
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD80
genes like me logo Genes that share disorders with CD80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD80 Gene

Publications for CD80 Gene

  1. Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T. … Mishima M. (Respiration 2005) 3 23 48 67
  2. Types I and II interferons upregulate the costimulatory CD80 molecule in monocytes via interferon regulatory factor-1. (PMID: 19433065) Bauvois B. … Kolb J.P. (Biochem. Pharmacol. 2009) 3 23
  3. Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma. (PMID: 17524139) Chang C.S. … Chung C.Y. (BMC Cancer 2007) 3 23
  4. Role of CD80 in stimulating T lymphocyte activation. (PMID: 16521215) Li D.C. … Fu J.X. (World J. Gastroenterol. 2006) 3 23
  5. CD80 transfected human hepatocellular carcinoma cells activate cytotoxic T lymphocytes to target HCC cells with shared tumor antigens. (PMID: 15254713) Chan R.C. … Xie Y. (Oncol. Rep. 2004) 3 23

Products for CD80 Gene

Sources for CD80 Gene

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