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CD80 Gene

protein-coding   GIFtS: 63
GCID: GC03M119243

CD80 Molecule

(Previous names: CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD8...)
(Previous symbols: CD28LG, CD28LG1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD80 Molecule1 2     BB12 3
CD28LG1 2 3 5     CTLA-4 Counter-Receptor B7.12 3
CD28LG11 2 3     B7-12
LAB72 3 5     B7.12
CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen)1 2     Costimulatory Factor CD802
B-Lymphocyte Activation Antigen B71 2     Costimulatory Molecule Variant IgV-CD802
Activation B7-1 Antigen2 3     T-Lymphocyte Activation Antigen CD802
B72 3     CD80 Antigen3

External Ids:    HGNC: 17001   Entrez Gene: 9412   Ensembl: ENSG000001215947   OMIM: 1122035   UniProtKB: P336813   

Export aliases for CD80 gene to outside databases

Previous GC identifers: GC03M115885 GC03M118875 GC03M120524 GC03M120564 GC03M120725 GC03M116618


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD80 Gene:
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The
activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for
adenovirus subgroup B and may play a role in lupus neuropathy. (provided by RefSeq, Aug 2011)

GeneCards Summary for CD80 Gene:
CD80 (CD80 molecule) is a protein-coding gene. Diseases associated with CD80 include sialadenitis, and histoplasmosis. GO annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.

UniProtKB/Swiss-Prot: CD80_HUMAN, P33681
Function: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and
cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell
activation

Gene Wiki entry for CD80 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD80 gene promoter:
         ISGF-3   STAT1   AP-1   ATF-2   NF-kappaB   AREB6   NF-kappaB2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD80 promoter sequence
   Search Chromatin IP Primers for CD80

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD80


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.3-q21   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.3-q21

CD80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD80 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M119243:  view genomic region     (about GC identifiers)

Start:
119,243,140 bp from pter      End:
119,278,481 bp from pter
Size:
35,342 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CD80_HUMAN, P33681 (See protein sequence)
Recommended Name: T-lymphocyte activation antigen CD80 precursor  
Size: 288 amino acids; 33048 Da
Subunit: Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a
periodic zipper-like arrangement. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for
these viruses
2 PDB 3D structures from and Proteopedia for CD80:
1DR9 (3D)        1I8L (3D)    
Secondary accessions: Q5DTA9 Q5DTB0
Alternative splicing: 3 isoforms:  P33681-1   P33681-2   P33681-3   (Soluble isoform. Expressed in T-cells activated by ConA, non-activated monocytes and monocytes activated with IFN-c)

Explore the universe of human proteins at neXtProt for CD80: NX_P33681

Explore proteomics data for CD80 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn53, Asn89, Asn98, Asn186, Asn207, Asn211, Asn226, Asn232
  • Modification sites at PhosphoSitePlus

  • See CD80 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005182.1  
    ENSEMBL proteins: 
     ENSP00000264246   ENSP00000418364   ENSP00000373165   ENSP00000373164  
    Reactome Protein details: P33681

    CD80 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD80
    OriGene Protein Over-expression Lysate for CD80
    OriGene MassSpec for CD80
    OriGene Custom Protein Services for CD80
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    Novus Biologicals CD80 Proteins
    Novus Biologicals CD80 Lysates
    Sino Biological Recombinant Protein for CD80
    Sino Biological Cell Lysate for CD80
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CD80 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD80 (B7-1/CD80)
    OriGene Antibodies for CD80
    OriGene Custom Antibody Services for CD80
    Novus Biologicals CD80 Antibodies
    Abcam antibodies for CD80
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CD80
    LSBio Antibodies in human, mouse, rat for CD80

    CD80 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CD80 (B7-1/CD80)
    GenScript Custom Assay Services for CD80
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P33681

    ProtoNet protein and cluster: P33681

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: CD80_HUMAN, P33681
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD80 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD80_HUMAN, P33681
    Function: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and
    cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell
    activation

         Genatlas biochemistry entry for CD80:
    cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86
    ligand

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11279502
    GO:0015026coreceptor activity NAS9915850
         
    CD80 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD80:
     Decreased viability of wild-ty  Synthetic lethal with c-Myc af 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd80):
     cellular  endocrine/exocrine gland  hematopoietic system  immune system  nervous system 

    CD80 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD80: Cd80tm1Lbgn Cd80tm1Shr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD80
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD80

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD80
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD80

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CD80 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD80 (see all 11):
    hsa-miR-146a hsa-miR-323b-3p hsa-miR-455-3p hsa-miR-3125 hsa-miR-3916 hsa-miR-138-1* hsa-miR-3649 hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmidCD80 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD80
    Predesigned siRNA for gene silencing in human, mouse, rat CD80

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD80

    Clone
    Products:
         
    OriGene clones in human, mouse for CD80 (see all 6)
    OriGene ORF clones in mouse, rat for CD80
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD80 (NM_005191)
    Sino Biological Human cDNA Clone for CD80
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD80
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD80

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD80
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD80 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD80


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD80_HUMAN, P33681: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    nucleus2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016021integral component of membrane IC9915850

    CD80 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD80 About   (see all 27)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.86
    Autoimmune thyroid disease0.61
    Allograft Rejection0.86
    Intestinal immune network for IgA production0.41
    Type I diabetes mellitus0.69
    Viral myocarditis0.40
    Graft-versus-host disease0.65
    2CD28 co-stimulation
    CD28 co-stimulation0.66
    CTLA4 inhibitory signaling0.32
    CD28 dependent PI3K/Akt signaling0.66
    CTLA4 Signaling0.30
    Costimulation by the CD28 family0.44
    CD28 dependent Vav1 pathway0.00
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CD80
        Th1 Differentiation
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD80 (see all 34)
        Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    JNK Pathway
    Tec Kinases Signaling
    Rho Family GTPases

    3 GeneGo (Thomson Reuters) Pathways for CD80
        Immune response ICOS pathway in T-helper cell
    Immune response CD28 signaling
    Immune response NFAT in immune response

    Selected BioSystems Pathways for CD80 (see all 6)
        Allograft Rejection
    Toll-like receptor signaling pathway
    TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells
    Inflammatory Response Pathway


    Selected Reactome Pathways for CD80 (see all 6)
        CD28 dependent Vav1 pathway
    Constitutive PI3K/AKT Signaling in Cancer
    CTLA4 inhibitory signaling
    PIP3 activates AKT signaling
    CD28 co-stimulation


    Selected Kegg Pathways  (Kegg details for CD80) (see all 10):
        Cell adhesion molecules (CAMs)
    Toll-like receptor signaling pathway
    Intestinal immune network for IgA production
    Type I diabetes mellitus
    Autoimmune thyroid disease


    CD80 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD80 (see all 12): 
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD80

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD80 (P336811, 3 ENSP000002642464) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTLA4P164101, 3, ENSP000003039394EBI-1031024,EBI-1030991 I2D: score=4 STRING: ENSP00000303939
    CD28P107473, ENSP000003248904I2D: score=3 STRING: ENSP00000324890
    CD86P420813, ENSP000003320494I2D: score=1 STRING: ENSP00000332049
    CD274Q9NZQ71, ENSP000003709894EBI-1031024,EBI-4314282 STRING: ENSP00000370989
    NGFRP081381, ENSP000001722294EBI-1031024,EBI-1387782 STRING: ENSP00000172229
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007267cell-cell signaling IC9915850
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0009967positive regulation of signal transduction NAS9915850
    GO:0016032viral process IEA--

    CD80 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD80

    2 DrugBank Compounds for CD80    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AbataceptBMS-188667 (see all 9)332348-12-6targetantagonist18041889 16357751 16932686 17020493 16573350 11752352 20080922 17212998 16971318
    BelataceptBMS-224818 (see all 2)706808-37-9target--17616278 16978033

    Selected Novoseek inferred chemical compound relationships for CD80 gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ctla4-ig 76.9 21 8228824 (2), 1385153 (2), 7515331 (2), 7545666 (2) (see all 11)
    tn 1000 53 1 17156728 (1)
    ct-26 25.9 2 16489051 (2)
    ionomycin 24.2 2 9780158 (2)
    cyclosporin a 20.8 4 16237117 (1), 18652845 (1), 1380533 (1)
    2-methoxyethanol 10.7 3 10459548 (2), 10477744 (1)
    rituximab 10.4 1 17456057 (1)
    allergens 4.6 1 15049782 (1)
    1-chloro-24-dinitrobenzene 3.18 3 12650676 (1), 17118622 (1)
    nitric oxide 1.82 4 10075022 (1), 19555217 (1)



    CD80 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD80 gene: 
    NM_005191.3  

    Unigene Cluster for CD80:

    CD80 molecule
    Hs.838  [show with all ESTs]
    Unigene Representative Sequence: BC042665
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264246(uc003ecq.3) ENST00000478182(uc010hqt.1 uc010hqu.1)
    ENST00000463729(uc003ecr.1) ENST00000383669 ENST00000383668
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD80 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD80 (see all 11):
    hsa-miR-146a hsa-miR-323b-3p hsa-miR-455-3p hsa-miR-3125 hsa-miR-3916 hsa-miR-138-1* hsa-miR-3649 hsa-miR-589
    SwitchGear 3'UTR luciferase reporter plasmidCD80 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD80
    Clone
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    OriGene ORF clones in mouse, rat for CD80
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD80 (NM_005191)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD80
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD80
    Primer
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    OriGene qPCR primer pairs and template standards for CD80
    OriGene qSTAR qPCR primer pairs in human, mouse for CD80
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD80
      QuantiTect SYBR Green Assays in human, mouse, rat CD80
      QuantiFast Probe-based Assays in human, mouse, rat CD80

    Additional mRNA sequence: 

    AK292129.1 AY081815.1 AY197777.1 AY197778.1 BC042665.1 M27533.1 

    3 DOTS entries:

    DT.455212  DT.203537  DT.99998167 

    15 AceView cDNA sequences:

    CA447659 AA731658 BC042665 CD366279 NM_005191 BU943171 AV716442 AY081815 
    BI822963 BF663116 AV717312 AW105040 AW118675 AI432226 AW370828 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CD80    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
    SP1:                                      -                             -         
    SP2:                                      -                                       
    SP3:                                      -           -                           
    SP4:                                      -     -     -                           
    SP5:                                                                              


    ECgene alternative splicing isoforms for CD80

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CD80 expression in normal human tissues (normalized intensities)      CD80 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCATTCT
    CD80 Expression
    About this image


    CD80 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Pelvic Girdle
             Placenta-derived mesenchymal stem cells (family)
     
     Limb (Muscoskeletal System)
             Bone Marrow Stromal Cells Pelvic Girdle
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Monocytes Peripheral Blood
             Immunosuppressive dendritic cells
    CD80 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD80 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.838

    UniProtKB/Swiss-Prot: CD80_HUMAN, P33681
    Tissue specificity: Expressed on activated B-cells, macrophages and dendritic cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD80 (see all 12): 
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD80 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd801 , 5 CD80 antigen1, 5 65.87(n)1
    47.41(a)1
      16 (26.86 cM)5
    125191  NM_009855.21  NP_033985.31 
     384589335 
    chicken
    (Gallus gallus)
    Aves CD806
    Gallus gallus CD80 molecule (CD80), mRNA.
    23(a)
    1 ↔ 1
    1(91635375-91642963)
    lizard
    (Anolis carolinensis)
    Reptilia CD806
    CD80 molecule
    23(a)
    1 ↔ 1
    3(162409944-162436467)


    ENSEMBL Gene Tree for CD80 (if available)
    TreeFam Gene Tree for CD80 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD80 gene
    CD862  

    CD80 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD80 (see all 793)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384986021,2
    --119243838(+) ATAAAA/GCCATT 1 -- ut310--------
    rs1828753171,2
    --119243846(+) ATTTAA/GAGAGA 1 -- ut310--------
    rs15997951,2
    C,F,O,H--119243855(+) GATTAA/TCAGTC 1 -- ut31 ese398Minor allele frequency- N:0.00NS MN EA NA PA EU CA WA 5461
    rs1877672041,2
    --119243918(+) TTTGAC/TGTACC 1 -- ut310--------
    rs1146797261,2
    C,F--119243933(+) TCATTC/GGTCTT 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs15997961,2
    C,F,O,A,H--119243934(+) CATTCG/ATCTTA 1 -- ut31 ese3107Minor allele frequency- A:0.20EA NA NS PA EU CA WA 6762
    rs1930147531,2
    --119244023(+) ACACAA/GTGAAA 1 -- ut310--------
    rs1829005531,2
    --119244076(+) CTCCTA/CAAGAT 1 -- ut310--------
    rs1139912631,2
    C--119244138(+) TAAAA-/TCTTCTAC 1 -- cds11Minor allele frequency- TCT:0.00CSA 2
    rs1496399691,2
    --119244171(+) TAGTCC/TCTGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD80 (119243140 - 119278481 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD80:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269361CNV Insertion20981092
    nsv829695CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 112203    OMIM disorders: --

    Selected diseases for CD80 (see all 114):    About MalaCards
    sialadenitis    histoplasmosis    wegener's granulomatosis    gastrointestinal system disease
    allergic encephalomyelitis    myasthenia gravis    sarcoidosis    graves' disease
    malt lymphoma    relapsing-remitting multiple sclerosis    optic neuritis    pulmonary disease, chronic obstructive
    neuritis    polymyositis    malignant glioma    lymphocytic choriomeningitis
    tetanus    pulmonary sarcoidosis    encephalomyelitis    vasculitis

    7 diseases from the University of Copenhagen DISEASES database for CD80:
    Leukemia     Hypersensitivity reaction type II disease     Tetanus     Rheumatoid arthritis
    Lymphoma     Asthma     Melanoma

    CD80 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CD80 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 49.9 30 7535196 (2), 11104808 (1), 15117323 (1), 19028921 (1) (see all 25)
    tumors 47.7 152 11228533 (5), 7515023 (4), 16489051 (4), 9930341 (3) (see all 83)
    tetanus 43.9 2 10084309 (1)
    autoimmune diseases 39 11 7690323 (2), 10201965 (1), 15870153 (1), 8813343 (1) (see all 8)
    lymphocytic leukemia chronic b-cell 29.3 5 9096698 (2), 11002221 (1), 9354461 (1)
    melanoma 27.2 35 7520026 (5), 12569387 (3), 10477389 (2), 7515929 (2) (see all 19)
    encephalomyelitis 26.1 2 11418697 (1), 8642061 (1)
    lymphoma follicular 25.8 2 9485189 (1), 7507734 (1)
    htlv-i infections 25.2 1 7632951 (1)
    multiple sclerosis 24.5 9 7533208 (4), 10227430 (1), 15544628 (1), 7500044 (1) (see all 5)

    Genetic Association Database (GAD): CD80
    Human Genome Epidemiology (HuGE) Navigator: CD80 (34 documents)

    Export disorders for CD80 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD80 gene, integrated from 10 sources (see all 772):
    (articles sorted by number of sources associating them with CD80)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PubMed id 15942292)1, 4, 9 Handa T....Mishima M. ( international review of thoracic diseases 2005)
    2. New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 11196673)1, 4, 9 Matsushita M....Tokunaga K. (Genes Immun. 2000)
    3. Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PubMed id 1377173)1, 2, 9 Selvakumar A....Dupont B. (Immunogenetics 1992)
    4. Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. (PubMed id 14975605)1, 4, 9 Teutsch S.M....Stewart G.J. (J. Neuroimmunol. 2004)
    5. The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21. (PubMed id 1370389)1, 3, 9 Freeman G.J....Nadler L.M. (Blood 1992)
    6. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    7. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    8. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    9. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    10. PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (PubMed id 20066438)1, 4 Ishizaki Y....Hara T. (Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 941 HGNC: 1700 AceView: CD80 Ensembl:ENSG00000121594 euGenes: HUgn941
    ECgene: CD80 Kegg: 941 H-InvDB: CD80

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD80 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD80 gene:
    Search GeneIP for patents involving CD80

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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