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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD80 Gene

protein-coding GIFtS: 64
GCID: GC03M119243

CD80 molecule

(Previous names: CD80 antigen (CD28 antigen ligand 1, B7-1 antigen), CD8...)
(Previous symbols: CD28LG, CD28LG1)

Explore 118 diseases affiliated with
CD80 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD80 Molecule¹ ²		B7² ³
CD28LG¹ ² ³ ⁵		BB1² ³
CD28LG1¹ ² ³		CTLA-4 Counter-Receptor B7.1² ³
LAB7² ³ ⁵		B-Lymphocyte Activation Antigen B7²
B7-1¹ ²		Costimulatory Factor CD80²
B7.1¹ ²		Costimulatory Molecule Variant IgV-CD80²
CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen)¹ ²		T-Lymphocyte Activation Antigen CD80²
Activation B7-1 Antigen² ³		CD80 Antigen³

External Ids:	HGNC: 1700¹	Entrez Gene: 941²	Ensembl: ENSG00000121594⁷	OMIM: 112203⁵	UniProtKB: P33681³

Export aliases for CD80 gene to outside databases

Previous GC identifers: GC03M115885 GC03M118875 GC03M120524 GC03M120564 GC03M120725 GC03M116618

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD80:

The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The

activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for

adenovirus subgroup B and may play a role in lupus neuropathy. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: CD80_HUMAN, P33681

Function: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine

production is induced by the binding of CD28 or CTLA-4 to this receptor

Gene Wiki entry for CD80

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD80 gene promoter:
ISGF-3 STAT1 AP-1 ATF-2 NF-kappaB AREB6 NF-kappaB2 c-Jun NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD80 promoter sequence

Search SABiosciences Chromatin IP Primers for CD80

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD80

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.3-q21 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3q13.3-q21

CD80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD80 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M119243: view genomic region (about GC identifiers)

Start:	119,243,140 bp from pter	End:	119,278,481 bp from pter
Size:	35,342 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD80_HUMAN, P33681 (See protein sequence)

Recommended Name: T-lymphocyte activation antigen CD80 precursor

Size: 288 amino acids; 33048 Da

Subunit: Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses

Subcellular location: Membrane; Single-pass type I membrane protein

2 PDB 3D structures from and Proteopedia for CD80:

1DR9 (3D)

1I8L (3D)

Explore the universe of human proteins at neXtProt for CD80: NX_P33681

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P33681

CD80 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005182.1

ENSEMBL proteins:

ENSP00000264246 ENSP00000418364 ENSP00000373165 ENSP00000373164

Reactome Protein details: P33681
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD80 (B7-1/CD80)
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	Novus Biologicals CD80 Proteins Novus Biologicals CD80 Lysates
	Sino Biological Recombinant Protein for CD80
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005886	plasma membrane	TAS	--
GO:0009897	external side of plasma membrane	IEA	--
GO:0016021	integral to membrane	IC	9915850

CD80 for ontologies About GeneDecksing

CD80 Antibody Products:

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	Novus Biologicals CD80 Antibodies
	Abcam antibodies for CD80
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	ThermoFisher Antibody for CD80

Assay Products for CD80:

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	R&D Systems ELISAs for CD80 (B7-1/CD80)
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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD80 for domains About GeneDecksing

5 InterPro domains/families:

IPR013162 CD80_C2-set

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry P33681

ProtoNet protein and cluster: P33681

1 Blocks protein family: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: CD80_HUMAN, P33681

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD80_HUMAN, P33681

Function: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine

production is induced by the binding of CD28 or CTLA-4 to this receptor

Genatlas biochemistry entry for CD80:

cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand

miRNA Products:		OriGene 3'-UTR Clone: CD80 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD80
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CD80 (see all 11):
		hsa-miR-146a hsa-miR-323b-3p hsa-miR-455-3p hsa-miR-3125 hsa-miR-3916 hsa-miR-138-1* hsa-miR-3649 hsa-miR-589

		SwitchGear 3'UTR luciferase reporter plasmid: CD80 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD80 (see all 7) OriGene shRNA RFP: CD80 OriGene siRNA: CD80
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD80

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD80

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD80 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD80 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD80 (NM_005191)
		Sino Biological Human cDNA Clone for CD80
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD80
		Search LifeMap BioReagents cell lines for CD80

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD80

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0015026	coreceptor activity	NAS	9915850

CD80 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CD80:

Decreased viability of wild-ty

Synthetic lethal with c-Myc af

Animal Models:
Mouse knock-outs for CD80: Cd80^tm1Lbgn Cd80^tm1Shr
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd80):

cellular

endocrine/exocrine gland

hematopoietic system

immune system

nervous system

CD80 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PEDF Induced Signaling

8/11 pathways (see all 11)
PEDF Induced Signaling	1.00	STAT3 Pathway	0.47
MIF Mediated Glucocorticoid Regulation	0.73	Endothelin-1 Signaling Pathway	0.44
MIF Regulation of Innate Immune Cells	0.71	NFAT Signaling and Lymphocyte Interactions	0.37
IL-6 Pathway	0.61	PGC1Alpha Pathway	0.33

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PI-3K cascade	1.00	PI3K/AKT activation	0.97
PIP3 activates AKT signaling	1.00	GAB1 signalosome	0.96
PI3K/AKT Signaling in Cancer	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Allograft rejection

Allograft rejection	1.00	Autoimmune thyroid disease	0.60
Type I diabetes mellitus	0.67	Intestinal immune network for IgA production	0.38
Graft-versus-host disease	0.63	Viral myocarditis	0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CD80

	Immune response CD28 signaling
	Immune response NFAT in immune response
	Immune response ICOS pathway in T-helper cell

2 R&D Systems Pathways for CD80

	Th1 Differentiation
	Th17 Differentiation

5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD80 (see all 34)

	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	JNK Pathway
	Tec Kinases Signaling
	Rho Family GTPases

3 GeneGo (Thomson Reuters) Pathways for CD80

	Immune response ICOS pathway in T-helper cell
	Immune response CD28 signaling
	Immune response NFAT in immune response

4 BioSystems Pathways for CD80

	Toll-like receptor signaling pathway
	TCR signaling in naive CD8+ T cells
	Inflammatory Response Pathway
	TCR signaling in naive CD4+ T cells

5/34 Reactome Pathways for CD80 (see all 34)

	CD28 dependent Vav1 pathway
	Costimulation by the CD28 family
	Signaling by EGFR in Cancer
	Downstream signal transduction
	Signal Transduction

5/10 Kegg Pathways (Kegg details for CD80) (see all 10):

	Cell adhesion molecules (CAMs)
	Toll-like receptor signaling pathway
	Intestinal immune network for IgA production
	Type I diabetes mellitus
	Autoimmune thyroid disease

CD80 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD80

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for CD80 (P33681^{1, 3} ENSP00000264246⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTLA4	P16410¹^,³, ENSP00000303939⁴	EBI-1031024,EBI-1030991 I2D: score=4 STRING: ENSP00000303939
CD28	P10747³, ENSP00000324890⁴	I2D: score=3 STRING: ENSP00000324890
CD86	P42081³, ENSP00000332049⁴	I2D: score=1 STRING: ENSP00000332049
CD274	Q9NZQ7¹, ENSP00000370989⁴	EBI-1031024,EBI-4314282 STRING: ENSP00000370989
NGFR	P08138¹, ENSP00000172229⁴	EBI-1031024,EBI-1387782 STRING: ENSP00000172229

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007267	cell-cell signaling	IC	9915850
GO:0009967	positive regulation of signal transduction	NAS	9915850
GO:0019048	virus-host interaction	IEA	--
GO:0031295	T cell costimulation	TAS	--
GO:0035556	intracellular signal transduction	NAS	9915850

CD80 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD80 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD80

1 DrugBank Compound for CD80 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Abatacept	CTLA4-Ig (see all 8)	332348-12-6	target	antagonist	18041889 16357751 16932686 17020493 16573350 11752352 20080922 17212998 16971318

10/27 Novoseek chemical compound relationships for CD80 gene (see all 27) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ctla4-ig	76.9	21	8228824 (2), 1385153 (2), 7515331 (2), 7545666 (2) (see all 11)
tn 1000	53	1	17156728 (1)
ct-26	25.9	2	16489051 (2)
ionomycin	24.2	2	9780158 (2)
cyclosporin a	20.8	4	16237117 (1), 18652845 (1), 1380533 (1)
2-methoxyethanol	10.7	3	10459548 (2), 10477744 (1)
rituximab	10.4	1	17456057 (1)
allergens	4.6	1	15049782 (1)
1-chloro-24-dinitrobenzene	3.18	3	12650676 (1), 17118622 (1)
nitric oxide	1.82	4	10075022 (1), 19555217 (1)

Search CenterWatch for drugs/clinical trials and news about CD80

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD80 gene:

NM_005191.3

Unigene Cluster for CD80:

CD80 molecule

Hs.838 [show with all ESTs]

Unigene Representative Sequence: BC042665

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000264246(uc003ecq.3) ENST00000478182(uc010hqt.1 uc010hqu.1)

ENST00000463729(uc003ecr.1) ENST00000383669 ENST00000383668

miRNA Products:		OriGene 3'-UTR Clone: CD80 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD80
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CD80 (see all 11):
		hsa-miR-146a hsa-miR-323b-3p hsa-miR-455-3p hsa-miR-3125 hsa-miR-3916 hsa-miR-138-1* hsa-miR-3649 hsa-miR-589

		SwitchGear 3'UTR luciferase reporter plasmid: CD80 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD80 (see all 7) OriGene shRNA RFP: CD80 OriGene siRNA: CD80
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD80

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD80 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD80 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD80 (NM_005191)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD80
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD80

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CD80
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD80
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD80

Additional cDNA sequence:

AK292129.1 AY081815.1 AY197777.1 AY197778.1 BC042665.1 M27533.1

3 DOTS entries:

DT.455212 DT.203537 DT.99998167

15 AceView cDNA sequences:

AA731658 CA447659 BC042665 NM_005191 CD366279 AV717312 AY081815 AV716442

BU943171 BF663116 AW105040 BI822963 AW118675 AI432226 AW370828

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CD80 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7
SP1:													-										-
SP2:													-
SP3:													-				-
SP4:													-		-		-
SP5:

ECgene alternative splicing isoforms for CD80

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD80 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCCATTCT

About this image

CD80 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Myeloid Dendritic Cells

Blood

Lung

Trachea

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See CD80 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD80

SOURCE GeneReport for Unigene cluster: Hs.838

UniProtKB/Swiss-Prot: CD80_HUMAN, P33681

Tissue specificity: Expressed on activated B-cells, macrophages and dendritic cells

SABiosciences Expression via Pathway-Focused PCR Arrays including CD80 (see all 12):

Cell Surface Markers in human mouse rat

NFKB Signaling Targets in human mouse rat

Antiviral Response in human mouse rat

Toll-Like Receptor Signaling Pathway in human mouse rat

Lymphoma in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD80 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD80

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD80 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CD80⁶	Uncharacterized protein	23(a)	1 ↔ 1	1(95614906-95639136)
lizard (Anolis carolinensis)	Reptilia	CD80⁶	--	26(a)	1 ↔ 1	3(162415916-162419162)

ENSEMBL Gene Tree for CD80 (if available)
TreeFam Gene Tree for CD80 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD80 gene

CD86²

CD80 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145900930^1,2		--	119242655(+)	`ATGTCC/TGATGA`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs14543^1,2	C	--	119242750(+)	`TTTTTC/TTTTTC`	2	--	ds500¹ ut3¹		1		NA	2
rs13532^1,2	C,F,	--	119242778(-)	`GTACAA/GCAGCC`	2	--	ut3¹ ds500¹		5		MN WA CSA	307
rs6641^1,2	C,F,A,	--	119242803(+)	`TCCTTA/CAATTT`	2	--	ds500¹ ut3¹		11		MN NA CSA EA	572
rs145997182^1,2	C,	--	119242832(+)	`GTATT-/AATC TATCA`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs12076^1,2	F	--	119242853(-)	`ATTCAC/TGTATG`	2	--	ds500¹ ut3¹		1		MN	184
rs111926984^1,2		--	119242900(+)	`CATTTG/CGCAAA`	2	--	ut3¹ ds500¹		1		CSA	2
rs11916272^1,2	C,F,H,	--	119242930(+)	`CAGTTC/TGTATA`	2	--	ds500¹ ut3¹		23		NS EA NA WA CSA	2351
rs191512755^1,2		--	119242933(+)	`TTCGTA/GTATTC`	2	--	ut3¹ ds500¹		0	--	--	--	--
rs4389515^1,2	C,H	--	119242959(+)	`AGGGTA/CTTCTA`	2	--	ds500¹ ut3¹		4		NS EA	418

HapMap Linkage Disequilibrium report for CD80 (119243140 - 119278481 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD80: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD80

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD80 for disorders           About GeneDecksing

OMIM gene information: 112203    OMIM disorders: --

20/118 diseases for CD80 (see all 118):    About MalaCards

relapsing-remitting multiple sclerosis b-cell non-hodgkin lymphoma hypersensitivity reaction type ii disease non-hodgkin lymphoma

neuropathy wegener's granulomatosis graft versus host disease myasthenia gravis

malt lymphoma inflammatory bowel disease sialadenitis optic neuritis

connective tissue disease primary biliary cirrhosis renal cell carcinoma chronic obstructive pulmonary disease

herpes simplex lupus erythematosus hodgkin's lymphoma b-cell lymphomas

9 diseases from the University of Copenhagen DISEASES database for CD80:

Hypersensitivity reaction type II disease Leukemia Multiple sclerosis Arthritis

Tetanus Melanoma Histoplasmosis Connective tissue disease

Lymphoma

10/94 Novoseek disease relationships for CD80 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	49.9	30	7535196 (2), 11104808 (1), 15117323 (1), 19028921 (1) (see all 25)
tumors	47.7	152	11228533 (5), 7515023 (4), 16489051 (4), 9930341 (3) (see all 83)
tetanus	43.9	2	10084309 (1)
autoimmune diseases	39	11	7690323 (2), 10201965 (1), 15870153 (1), 8813343 (1) (see all 8)
lymphocytic leukemia chronic b-cell	29.3	5	9096698 (2), 11002221 (1), 9354461 (1)
melanoma	27.2	35	7520026 (5), 12569387 (3), 10477389 (2), 7515929 (2) (see all 19)
encephalomyelitis	26.1	2	11418697 (1), 8642061 (1)
lymphoma follicular	25.8	2	9485189 (1), 7507734 (1)
htlv-i infections	25.2	1	7632951 (1)
multiple sclerosis	24.5	9	7533208 (4), 10227430 (1), 15544628 (1), 7500044 (1) (see all 5)

Genetic Association Database (GAD): CD80
Human Genome Epidemiology (HuGE) Navigator: CD80 (34 documents)

Export disorders for CD80 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD80 gene, integrated from 9 sources (see all 757):
(articles sorted by number of sources associating them with CD80)

Utopia: connect your pdf to the dynamic
world of online information

Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PubMed id 15942292)^{1, 4, 9} Handa T....Mishima M. (2005)
New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 11196673)^{1, 4, 9} Matsushita M....Tokunaga K. (2000)
Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PubMed id 1377173)^{1, 2, 9} Selvakumar A....Dupont B. (1992)
Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. (PubMed id 14975605)^{1, 4, 9} Teutsch S.M....Stewart G.J. (2004)
The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21. (PubMed id 1370389)^{1, 3, 9} Freeman G.J....Nadler L.M. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
Structure and dimerization of a soluble form of B7-1. (PubMed id 10661405)^{1, 2} Ikemizu S.... Davis S.J. (2000)
CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. (PubMed id 7527824)^{1, 2} Lanier L.L.... Azuma M. (1995)
Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. (PubMed id 1714935)^{1, 2} Freeman G.J.... Nadler L.M. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 941	HGNC: 1700	AceView: CD80	Ensembl:ENSG00000121594	euGenes: HUgn941
ECgene: CD80	Kegg: 941	H-InvDB: CD80

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD80	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CD80 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD80 gene:
Search GeneIP for patents involving CD80

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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