Aliases for CD80 Gene
External Ids for CD80 Gene
Previous HGNC Symbols for CD80 Gene
Previous GeneCards Identifiers for CD80 Gene
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD80 Gene
CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Systemic Lupus Erythematosus. Among its related pathways are phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex and Immune response NFAT in immune response. GO annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.
UniProtKB/Swiss-Prot for CD80 Gene
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
(Microbial infection) Acts as a receptor for adenovirus subgroup B.