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CD79B Gene

protein-coding GIFtS: 62

GC17M059359

CD79b molecule, immunoglobulin-associated beta
(Previous name: CD79B antigen (immunoglobulin-associated beta) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: IGB)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
B29 ^¹, ², ³, ⁵
IGB ^², ³, ⁵
Ig-beta ^², ³

Descriptions
B-cell antigen receptor complex-associated protein beta chain ^²
B-cell-specific glycoprotein B29 ^², ³
CD79B antigen (immunoglobulin-associated beta) ^¹, ²
CD79b antigen ^², ³
CD79b molecule, immunoglobulin-associated beta ^²
Immunoglobulin-associated B29 protein ^³
immunoglobulin-associated B29 ^²

External Ids
HGNC: 1699¹
Entrez Gene: 974²
UniProtKB: P40259³
Ensembl: ENSG00000007312⁷

Search outside databases for aliases for CD79B gene

Previous GC identifers: GC17M061643 GC17M064432 GC17M062346 GC17M062479

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CD79B:

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific

component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other

proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell

antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component.

Alternatively spliced transcript variants encoding different isoforms have been described.

[provided by RefSeq]

UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259

Function: Required in cooperation with CD79A for initiation of the signal transduction cascade

activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the

complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of

CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which

bind to CD79A and protect it from dephosphorylation

Gene Wiki entry for CD79B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CD79B gene

Entrez Gene cytogenetic band: 17q23 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23

CD79B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M059359: (about GC identifiers)

Start:	59,359,830 bp from pter
End:	59,363,446 bp from pter
Size:	3,617 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259 (See protein sequence)

Recommended Name: B-cell antigen receptor complex-associated protein beta chain precursor

Size: 229 amino acids; 26048 Da

Subunit: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen

receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an

antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Following antigen

binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane

to lipid rafts although signal transduction through the complex can also occur outside lipid rafts

(By similarity)

Secondary accessions: Q53FS2 Q9BU06

Alternative splicing: 2 isoforms: P40259-1 P40259-2

Post-translational modifications:

Phosphorylated on tyrosine upon B-cell activation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000617.1 NP_001035022.1 NP_067613.1

ENSEMBL proteins:

ENSP00000376544 ENSP00000006750 ENSP00000245862

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD79b)
	Human Recombinant Proteins from Abnova (CD79B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0005794	Golgi apparatus	IDA	18029348
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8486355

About this table

Antibodies for CD79B:

	Invitrogen Antibodies for CD79B
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CD79B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (CD79b), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CD79B)
	Novus Biologicals Antibodies for CD79B

Assays for CD79B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P40259

ProtoNet protein and cluster: P40259

3 Blocks protein families:

IPB003110 Phosphorylated immunoreceptor signaling ITAM

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

Similarity: Contains 1 ITAM domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD79B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD79B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_021602

Applied Biosystems Silencer® siRNAs for CD79B

Sigma-Aldrich siRNA and siRNA Panels for CD79B

Sigma-Aldrich shRNA for CD79B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CD79B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000626
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000626
untagged cDNA clones in CMV expression vector (see all 4): NM_000626

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001039933

UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259

Function: Required in cooperation with CD79A for initiation of the signal transduction cascade

activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the

complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of

CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which

bind to CD79A and protect it from dephosphorylation

Genatlas biochemistry entry for CD79B:

cell differentiation antigen CD79B,expressed on B cells

4 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Cd79b):

hematopoietic system

immune system

no phenotypic analysis

normal

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for CD79B (Your Favorite Gene powered by Ingenuity)

B Cell Receptor Signaling
Role of NFAT in Regulation of the Immune Response
Fc&gamma

GeneDecks CD79B for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CD79B

5/47 Interacting proteins for CD79B (ENSP00000006750³) via UniProtKB, MINT, and/or STRING (see all 47 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD19	ENSP00000313419³	STRING (score=.998)
SYK	ENSP00000364898³	STRING (score=.996)
SHC1	ENSP00000357432³	STRING (score=.991)
CD79A	ENSP00000221972³	STRING (score=.99)
PTPRC	ENSP00000356346³	STRING (score=.988)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	8486355
GO:0007166	cell surface receptor linked signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CD79B
7 Novoseek chemical compound relationships for CD79B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	65.23	47	7592958 (4), 8559152 (2), 7524079 (2), 8125135 (2) (see all 27)
digitonin	48.20	1	1386314 (1)
phosphotyrosine	30.75	1	8765045 (1)
phosphoinositide	29.44	2	12459553 (2)
calcium	13.37	4	7509805 (1), 8262964 (1), 7688784 (1)
phosphatidylinositol	8.49	2	1373499 (1), 8419471 (1)
threonine	0.00	1	10900006 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD79B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD79B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_021602

Sigma-Aldrich siRNA and siRNA Panels for CD79B

Sigma-Aldrich shRNA for CD79B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000626 NM_001039933 NM_021602

REFSEQ mRNAs for CD79B gene (3 alternative transcripts):

NM_000626.2 NM_001039933.1 NM_021602.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000626 NM_001039933 NM_021602

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000626
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000626
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_000626

Additional cDNA sequence:

AK222954.1 AK223210.1 AK313583.1 BC002975.1 BC030210.1 BC032651.1 CR591997.1 CR592092.1

CR599571.1 CR606875.1 CR608074.1 CR617922.1 CR618467.1 CR623737.1 M80461.1 M89957.1

S52229.1 S79249.1 X83539.1

7 DOTS entries:

DT.311555 DT.100754192 DT.95080712 DT.100020983 DT.120966709 DT.91744311 DT.95301786

24/207 AceView cDNA sequences (see all 207 ):

BG392020 AU099391 BM920096 BM924097 BI836408 AY212253 CR623737 CR599571

BX280250 AL559878 CA415356 BX336723 CR591997 BG755705 CR617922 S79249

AU105583 CR606875 CR592092 CR618467 CR608074 AI239619 X83539 BF663298

highest scoring ESTs for CD79B:

M89957 AA904662 AU099391 AW404292 AW404525 AW404912 AW405827 AW406235 AW406444 AW407159

Unigene Cluster for CD79B:

CD79b molecule, immunoglobulin-associated beta

Hs.89575 [show with all ESTs]

Unigene Representative Sequence: AK223210

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CD79B (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6a	·	6b	·	6c
SP1:											-		-		-
SP2:											-		-		-
SP3:											-		-		-		-		-
SP4:
SP5:											-

About this scheme

ECgene alternative splicing isoforms for CD79B

3 Ensembl transcripts including schematic representations:

ENST00000392795 ENST00000006750 ENST00000349817

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CD79B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CD79B

¹ / ² / ³

5 probe-sets matching CD79B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37988_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M89957	1.00	1.00	1.00	1
205297_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000626	0.60	1.00	0.82	1
205297_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555748_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555746_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CD79B for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.89575
Expression variation in blood from EXPOLDB for CD79B
UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259
Tissue specificity: B-cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CD79B gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CD79B¹	--	CD79b molecule, immunoglobulin-associated beta	80.65(n) 78.12(a)	609449 XM_845323.1 XP_850416.1
chimpanzee (Pan troglodytes)	CD79B¹	--	CD79b molecule, immunoglobulin-associated beta	99.13(n) 99.13(a)	454773 XM_001150953.1 XP_001150953.1
rat (Rattus norvegicus)	Cd79b¹	--	Cd79b molecule, immunoglobulin-associated beta	75.77(n) 70.48(a)	171055 NM_133533.2 NP_598217.1
mouse (Mus musculus)	Cd79b^{1, 5}	11 (65.00 cM)⁵	CD79B antigen^{1, 5}	75.62(n)¹ 69.6(a)¹	15985¹ NM_008339.1¹ NP_032365.1¹ AF002279⁵ AK143573⁵ (see all 9)
chicken (Gallus gallus)	CD79B¹	--	CD79b molecule, immunoglobulin-associated beta	57.72(n) 43.06(a)	419940 NM_001006328.2 NP_001006328.2

About this table Species with no ortholog for CD79B

ENSEMBL Gene Tree for CD79B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/39 NCBI SNPs in CD79B are shown (see all 39 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 38)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs12946669^1,2	A,C,F,H	59359739(+)	`ACCCTC/TGAGGG`	3	--	ng5¹		8	EU EA WA	838
	rs1051684^1,2	A,C,F,H	59360229(-)	`TTTCCC/TGGACC`	3	--	ut3¹ ese³ trp³		5	MN EU EA WA	590
	rs11079515^1,2	A,C,F,H	59359377(+)	`CCTACC/GCTCAG`	3	--	ng5¹		12	EU EA WA NA	1186
	rs2286565^1,2	A,C,F,H	59363964(+)	`TGGAGG/TATGGG`	3	--	ng3¹		11	EA MN EU WA NA	2632
	rs12452767^1,2	A,C,F	59364235(+)	`AACAGG/AAGCTG`	3	--	ng3¹		2	MN EA	356
	rs2286564^1,2	A,C,F	59363723(+)	`TGCCAA/GCTCCC`	3	--	ng3¹		3	EA MN	1846
	rs3815358^1,2	A,C,F	59364002(+)	`GGTCAA/GGTGTG`	3	--	ng3¹ tfbs³		3	EA MN	1856
	rs7921^1,2	C,F,H	59359991(-)	`GGAGCC/TGAGGG`	3	--	ut3¹ ese³		9	MN NA EU EA WA	914
	rs16947270^1,2	C,F,H	59364529(+)	`ATCGTC/TGGTGC`	3	--	ng3¹		11	NA EU EA WA	978
--	rs1051688^1,2	A,C	59360165(-)	`CTGGTC/GCCCAG`	3	--	ut3¹ ese³		1	MN	184

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HapMap Linkage Disequilibrium images for CD79B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147245 disorders: 612692

UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259

Defects in CD79B are a cause of non-Bruton type agammaglobulinemia [MIM:601495].

Agammaglobulinemia is an immunodeficiency disease which results in developmental defects in the

maturation pathway of B-cells

10 Novoseek disease relationships for CD79B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia lymphocytic chronic	62.98	7	10552962 (2), 10048429 (1), 10753858 (1), 9269755 (1)
leukemia b-cell	57.06	4	10753858 (1), 10792036 (1)
lymphocytic leukemia chronic b-cell	50.26	4	10753858 (1), 10792036 (1)
leukaemia lymphocytic	46.02	2	10090943 (1), 16156858 (1)
plasmacytoma	36.98	1	11907094 (1)
myeloma	33.78	4	11504918 (1), 19187782 (1)
lymphoma	25.88	1	7681402 (1)
leukemia	16.34	2	10753858 (1), 9269755 (1)
lymphoma b-cell	6.35	1	7887308 (1)
aids	0.00	1	8032536 (1)

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1 PharmGKB disease relationship for CD79B gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

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Human Gene Mutation Database: CD79B

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/150 PubMed articles for CD79B gene (see all 150 ):

The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism. (PubMed id 7913081)^{1, 3, 4} Hashimoto S.... Gregersen P.K. (1994)
The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes. (PubMed id 8419481)^{1, 3, 4} Hashimoto S.... Chiorazzi N. (1993)
Isolation and chromosomal mapping of the human immunoglobulin- associated B29 gene (IGB). (PubMed id 8486355)^{1, 3, 4} Wood W.J. Jr.... Denny C.T. (1993)
Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. (PubMed id 1534761)^{1, 3, 4} Mueller B.S.... Terhorst C. (1992)
Physical linkage of the B29/Ig-beta (CD79B) gene to the skeletal muscle, sodium-channel, and growth hormone genes in rat and human. (PubMed id 9545642)^{1, 2, 3} Nakazato S....Ono M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells. (PubMed id 7643857)^{3, 4} Hashimoto S.... Gregersen P.K. (1995)
Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex. (PubMed id 7514267)^{3, 4} Vasile S.... Seon B.K. (1994)
Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific B29 (Ig beta) and mb-1 (Ig alpha) promoters. (PubMed id 11907094)^{1, 3} Malone C.S. and Wall R. (2002)
Igbeta(CD79b) mRNA expression in chronic lymphocytic leukaemia cells correlates with immunoglobulin heavy chain gene mutational status but does not serve as an independent predictor of clinical severity. (PubMed id 17315213)^{1, 3} Cajiao I....Liebhaber S.A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 974	HGNC: 1699	AceView: SCN4AandCD79B	Ensembl:ENSG00000007312	euGenes: HUgn974
ECgene: CD79B	H-InvDB: CD79B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
CD79Bbase	http://bioinf.uta.fi/CD79Bbase/

Licensable Technologies for CD79B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CD79B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CD79B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CD79B		Antibodies for CD79B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CD79B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CD79B)
	Antibodies (CD79B)
	Chimera RNAi (CD79B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (CD79b)
	Antibodies (CD79b)

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Antibodies for CD79B

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CD79B Gene at Home site.
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CD79B Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for CD79B

Summaries
for CD79B

Genomic Location
for CD79B

Proteins
for CD79B

Protein Domains/
Families
for CD79B

Gene Function
for CD79B

Pathways & Interactions
for CD79B

Drugs & Compounds
for CD79B

Transcripts
for CD79B

Expression
for CD79B

Orthologs
for CD79B

Paralogs
for CD79B

SNPs/Variants
for CD79B

Disorders & Mutations
for CD79B

Medical News
for CD79B

Publications
for CD79B

Search for CD79B

Genome Databases showing CD79B

Other Databases showing CD79B

Specialized Databases showing CD79B

Licensable Technologies
for CD79B

Services
for CD79B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CD79B Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor CD79B

Summariesfor CD79B

Genomic Locationfor CD79B

Proteinsfor CD79B

Protein Domains/Familiesfor CD79B

Gene Functionfor CD79B

Pathways & Interactionsfor CD79B

Drugs & Compoundsfor CD79B

Transcriptsfor CD79B

Expression for CD79B

Orthologsfor CD79B

Paralogsfor CD79B

SNPs/Variantsfor CD79B

Disorders & Mutationsfor CD79B

Medical Newsfor CD79B

Publicationsfor CD79B

Search for CD79B

Genome Databases showing CD79B

Other Databases showing CD79B

Specialized Databases showing CD79B

Licensable Technologiesfor CD79B

Servicesfor CD79B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CD79B

Summaries
for CD79B

Genomic Location
for CD79B

Proteins
for CD79B

Protein Domains/
Families
for CD79B

Gene Function
for CD79B

Pathways & Interactions
for CD79B

Drugs & Compounds
for CD79B

Transcripts
for CD79B

Expression
for CD79B

Orthologs
for CD79B

Paralogs
for CD79B

SNPs/Variants
for CD79B

Disorders & Mutations
for CD79B

Medical News
for CD79B

Publications
for CD79B

Licensable Technologies
for CD79B

Services
for CD79B