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Aliases for CD79B Gene

Aliases for CD79B Gene

  • CD79b Molecule, Immunoglobulin-Associated Beta 2 3
  • CD79B Antigen (Immunoglobulin-Associated Beta) 2 3
  • Immunoglobulin-Associated B29 Protein 3 4
  • B-Cell-Specific Glycoprotein B29 3 4
  • Ig-Beta 3 4
  • IGB 3 4
  • B29 3 4
  • CD79b Antigen 4
  • AGM6 3

External Ids for CD79B Gene

Previous HGNC Symbols for CD79B Gene

  • IGB

Previous GeneCards Identifiers for CD79B Gene

  • GC17M061643
  • GC17M064432
  • GC17M062346
  • GC17M062479
  • GC17M059359
  • GC17M062006
  • GC17M057373

Summaries for CD79B Gene

Entrez Gene Summary for CD79B Gene

  • The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD79B Gene

CD79B (CD79b Molecule, Immunoglobulin-Associated Beta) is a Protein Coding gene. Diseases associated with CD79B include agammaglobulinemia 6 and ecthyma. Among its related pathways are Immune System and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for CD79B Gene

  • Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Gene Wiki entry for CD79B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD79B Gene

Genomics for CD79B Gene

Regulatory Elements for CD79B Gene

Genomic Location for CD79B Gene

Chromosome:
17
Start:
63,928,738 bp from pter
End:
63,932,354 bp from pter
Size:
3,617 bases
Orientation:
Minus strand

Genomic View for CD79B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD79B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD79B Gene

Proteins for CD79B Gene

  • Protein details for CD79B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40259-CD79B_HUMAN
    Recommended name:
    B-cell antigen receptor complex-associated protein beta chain
    Protein Accession:
    P40259
    Secondary Accessions:
    • Q53FS2
    • Q9BU06

    Protein attributes for CD79B Gene

    Size:
    229 amino acids
    Molecular mass:
    26048 Da
    Quaternary structure:
    • Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity).

    Three dimensional structures from OCA and Proteopedia for CD79B Gene

    Alternative splice isoforms for CD79B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD79B Gene

Proteomics data for CD79B Gene at MOPED

Post-translational modifications for CD79B Gene

  • Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK
  • Glycosylation at Asn 73, Asn 101, Asn 127, and Asn 128
  • Modification sites at PhosphoSitePlus

Other Protein References for CD79B Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for CD79B

No data available for DME Specific Peptides for CD79B Gene

Domains & Families for CD79B Gene

Gene Families for CD79B Gene

Suggested Antigen Peptide Sequences for CD79B Gene

Graphical View of Domain Structure for InterPro Entry

P40259

UniProtKB/Swiss-Prot:

CD79B_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 1 ITAM domain.
genes like me logo Genes that share domains with CD79B: view

Function for CD79B Gene

Molecular function for CD79B Gene

GENATLAS Biochemistry:
cell differentiation antigen CD79B,expressed on B cells
UniProtKB/Swiss-Prot Function:
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Gene Ontology (GO) - Molecular Function for CD79B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CD79B: view
genes like me logo Genes that share phenotypes with CD79B: view

Animal Models for CD79B Gene

MGI Knock Outs for CD79B:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD79B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CD79B Gene

Localization for CD79B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD79B Gene

Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD79B Gene COMPARTMENTS Subcellular localization image for CD79B gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 4
nucleus 4
cytosol 2
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for CD79B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8486355
genes like me logo Genes that share ontologies with CD79B: view

Pathways & Interactions for CD79B Gene

genes like me logo Genes that share pathways with CD79B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for CD79B Gene

Activates:

Gene Ontology (GO) - Biological Process for CD79B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006955 immune response TAS 8486355
GO:0007165 signal transduction TAS 8486355
GO:0007166 cell surface receptor signaling pathway --
GO:0050853 B cell receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with CD79B: view

Drugs & Compounds for CD79B Gene

(4) Drugs for CD79B Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
serine Nutra 420
threonine Nutra 16
tyrosine Nutra 547

(4) Additional Compounds for CD79B Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
digitonin
Phosphatidylinositol
phosphoinositide
Phosphotyrosine
genes like me logo Genes that share compounds with CD79B: view

Transcripts for CD79B Gene

Unigene Clusters for CD79B Gene

CD79b molecule, immunoglobulin-associated beta:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD79B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD79B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4:
SP5: -
SP6:

Relevant External Links for CD79B Gene

GeneLoc Exon Structure for
CD79B
ECgene alternative splicing isoforms for
CD79B

Expression for CD79B Gene

mRNA expression in normal human tissues for CD79B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD79B Gene

This gene is overexpressed in Spleen (x12.6), Whole Blood (x7.6), Pituitary (x5.0), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for CD79B Gene

This gene is overexpressed in Blymphocyte (36.0), Monocytes (16.0), and Lymph node (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD79B Gene



SOURCE GeneReport for Unigene cluster for CD79B Gene Hs.89575

mRNA Expression by UniProt/SwissProt for CD79B Gene

P40259-CD79B_HUMAN
Tissue specificity: B-cells
genes like me logo Genes that share expression patterns with CD79B: view

Protein tissue co-expression partners for CD79B Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CD79B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD79B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD79B 35
  • 77.94 (n)
  • 71.01 (a)
CD79B 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD79B 35
  • 80.59 (n)
  • 78.22 (a)
CD79B 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd79b 35
  • 75.04 (n)
  • 69.16 (a)
Cd79b 16
Cd79b 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD79B 35
  • 98.98 (n)
  • 99.13 (a)
CD79B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd79b 35
  • 75.92 (n)
  • 70.48 (a)
oppossum
(Monodelphis domestica)
Mammalia CD79b 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD79B 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD79B 35
  • 57.98 (n)
  • 42.79 (a)
CD79B 36
  • 39 (a)
OneToOne
Species with no ortholog for CD79B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD79B Gene

ENSEMBL:
Gene Tree for CD79B (if available)
TreeFam:
Gene Tree for CD79B (if available)

Paralogs for CD79B Gene

No data available for Paralogs for CD79B Gene

Variants for CD79B Gene

Sequence variations from dbSNP and Humsavar for CD79B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs7921 -- 63,928,899(-) GGAGC(C/T)GAGGG utr-variant-3-prime
rs1051684 -- 63,929,137(-) TTTCC(C/T)GGACC utr-variant-3-prime
rs1051688 -- 63,929,073(-) CTGGT(C/G/T)CCCAG utr-variant-3-prime
rs1063625 -- 63,929,267(-) CAGGG(A/G)AAGTG missense, reference
rs2003549 -- 63,931,077(-) AGCCT(A/G)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD79B Gene

Variant ID Type Subtype PubMed ID
nsv517272 CNV Gain+Loss 19592680
nsv833511 CNV Loss 17160897
nsv908684 CNV Loss 21882294

Variation tolerance for CD79B Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD79B Gene

HapMap Linkage Disequilibrium report
CD79B
Human Gene Mutation Database (HGMD)
CD79B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD79B Gene

Disorders for CD79B Gene

MalaCards: The human disease database

(6) MalaCards diseases for CD79B Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
agammaglobulinemia 6
  • agammaglobulinemia 6, autosomal recessive
ecthyma
autosomal agammaglobulinemia
  • agammaglobulinemia, non-bruton type
agammaglobulinemia
  • ighm
chronic lymphocytic leukemia
  • lymphoplasmacytic leukemia
- elite association
Search CD79B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD79B_HUMAN
  • Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269 PubMed:17675462}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CD79B

Genetic Association Database (GAD)
CD79B
Human Genome Epidemiology (HuGE) Navigator
CD79B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD79B
genes like me logo Genes that share disorders with CD79B: view

No data available for Genatlas for CD79B Gene

Publications for CD79B Gene

  1. Physical linkage of the B29/Ig-beta (CD79B) gene to the skeletal muscle, sodium-channel, and growth hormone genes in rat and human. (PMID: 9545642) Nakazato S. … Ono M. (Genomics 1998) 2 23 67
  2. Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth. (PMID: 20043832) Ke J. … Bondada S. (Mol. Cancer 2009) 23 67
  3. Ig beta deficiency in humans. (PMID: 18978465) Lougaris V. … Plebani A. (Curr Opin Allergy Clin Immunol 2008) 23 67
  4. Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor. (PMID: 17878339) Zhang M. … Clark M.R. (J. Immunol. 2007) 23 67
  5. Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment. (PMID: 17522256) Haga C.L. … Cooper M.D. (Proc. Natl. Acad. Sci. U.S.A. 2007) 23 67

Products for CD79B Gene

Sources for CD79B Gene

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