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CD79B Gene

protein-coding   GIFtS: 63
GCID: GC17M062006

CD79b Molecule, Immunoglobulin-Associated Beta

(Previous name: CD79B antigen (immunoglobulin-associated beta))
(Previous symbol: IGB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD79b Molecule, Immunoglobulin-Associated Beta1 2     Ig-beta2 3
IGB1 2 3 5     B-Cell-Specific Glycoprotein B292 3
B292 3 5     AGM62 5
CD79B Antigen (Immunoglobulin-Associated Beta)1 2     B-Cell Antigen Receptor Complex-Associated Protein Beta Chain2
Immunoglobulin-Associated B29 Protein2 3     CD79b Antigen3

External Ids:    HGNC: 16991   Entrez Gene: 9742   Ensembl: ENSG000000073127   OMIM: 1472455   UniProtKB: P402593   

Export aliases for CD79B gene to outside databases

Previous GC identifers: GC17M061643 GC17M064432 GC17M062346 GC17M062479 GC17M059359 GC17M057373


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD79B Gene:
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface
immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which
are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein
of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been
described. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD79B Gene:
CD79B (CD79b molecule, immunoglobulin-associated beta) is a protein-coding gene. Diseases associated with CD79B include familial chronic lymphocytic leukemia, and agammaglobulinemia 6. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259
Function: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the
B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late
endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which
phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation

Gene Wiki entry for CD79B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD79B gene promoter:
         HOXA9   HOXA9B   Elk-1   LUN-1   E47   Meis-1b   GATA-2   Hand1   SEF-1 (1)   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD79B promoter sequence
   Search Chromatin IP Primers for CD79B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD79B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23

CD79B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD79B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M062006:  view genomic region     (about GC identifiers)

Start:
62,006,098 bp from pter      End:
62,009,714 bp from pter
Size:
3,617 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259 (See protein sequence)
Recommended Name: B-cell antigen receptor complex-associated protein beta chain precursor  
Size: 229 amino acids; 26048 Da
Subunit: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where
the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface
immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity)
1 PDB 3D structure from and Proteopedia for CD79B:
3KG5 (3D)    
Secondary accessions: Q53FS2 Q9BU06
Alternative splicing: 3 isoforms:  P40259-1   P40259-2   P40259-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD79B: NX_P40259

Explore proteomics data for CD79B at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK1
  • Glycosylation2 at Asn73, Asn101, Asn127, Asn128
  • Modification sites at PhosphoSitePlus

  • See CD79B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000617.1  NP_001035022.1  NP_067613.1  

    ENSEMBL proteins: 
     ENSP00000376544   ENSP00000006750   ENSP00000245862  
    Reactome Protein details: P40259

    CD79B Human Recombinant Protein Products:

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    CD79B Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR003110 Phos_immunorcpt_sig_ITAM
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P40259

    ProtoNet protein and cluster: P40259

    3 Blocks protein domains:
    IPB003110 Phosphorylated immunoreceptor signaling ITAM
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
    Similarity: Contains 1 ITAM domain


    CD79B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD79B_HUMAN, P40259
    Function: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the
    B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late
    endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which
    phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation

         Genatlas biochemistry entry for CD79B:
    cell differentiation antigen CD79B,expressed on B cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity IEA--
    GO:0005515protein binding ----
         
    CD79B for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Cd79b):
     hematopoietic system  immune system  no phenotypic analysis  normal 

    CD79B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD79B: Cd79btm1Mnz Cd79btm2.1Mnz Cd79btm2Mnz

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD79B
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    hsa-miR-593 hsa-miR-654-5p hsa-miR-3144-5p hsa-miR-541
    SwitchGear 3'UTR luciferase reporter plasmidCD79B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD79B_HUMAN, P40259: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR
    has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal
    transduction through the complex can also occur outside lipid rafts (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus4
    nucleus4
    cytosol3
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    endosome1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane TAS--

    CD79B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD79B About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
    Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.47
    B-Cell Receptor Complex0.00
    2B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    3Downstream Signaling Events Of B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.79
    4CREB Pathway
    IP3 Pathway0.68
    5GPCR Pathway
    NFAT in Immune Response0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD79B (see all 6)
        Fc-Gamma-RIIB Signaling in B-Cells
    B-Cell Receptor Complex
    IP3 Pathway
    Phospholipase-C Pathway
    PI3K Signaling in B-Lymphocyte

    3 GeneGo (Thomson Reuters) Pathways for CD79B
        Immune response BCR pathway
    Signal transduction IP3 signaling
    Immune response NFAT in immune response

    2 BioSystems Pathways for CD79B
        B Cell Receptor Signaling Pathway
    BCR signaling pathway


    1 Reactome Pathway for CD79B
        Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


    1 Kegg Pathway  (Kegg details for CD79B):
        B cell receptor signaling pathway


    CD79B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CD79B: 
              Cell Surface Markers in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD79B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD79B (P402593 ENSP000003765444) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BLKP514513, ENSP000002590894I2D: score=3 STRING: ENSP00000259089
    CD19P153913, ENSP000003134194I2D: score=3 STRING: ENSP00000313419
    CD79AP119123, ENSP000002219724I2D: score=3 STRING: ENSP00000221972
    SYKP434053, ENSP000003648984I2D: score=3 STRING: ENSP00000364898
    CD3EP077663, ENSP000003545664I2D: score=2 STRING: ENSP00000354566
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS8486355
    GO:0007165signal transduction TAS8486355
    GO:0007166cell surface receptor signaling pathway ----
    GO:0050853B cell receptor signaling pathway IEA--

    CD79B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD79B

    8 Novoseek inferred chemical compound relationships for CD79B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 64.9 48 7592958 (4), 8559152 (2), 7524079 (2), 8125135 (2) (see all 28)
    digitonin 47.6 1 1386314 (1)
    phosphotyrosine 30.1 1 8765045 (1)
    phosphoinositide 28.2 2 12459553 (2)
    calcium 12.5 4 7509805 (1), 8262964 (1), 7688784 (1)
    phosphatidylinositol 7.4 2 1373499 (1), 8419471 (1)
    threonine 0 1 10900006 (1)
    serine 0 1 10900006 (1)



    CD79B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD79B gene (3 alternative transcripts): 
    NM_000626.2  NM_001039933.1  NM_021602.2  

    Unigene Cluster for CD79B:

    CD79b molecule, immunoglobulin-associated beta
    Hs.89575  [show with all ESTs]
    Unigene Representative Sequence: AK223210
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392795 ENST00000006750(uc002jdp.1 uc002jdq.1 uc002jdr.1)
    ENST00000559358 ENST00000349817 ENST00000558969 ENST00000583260
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    Additional mRNA sequence: 

    AK222954.1 AK223210.1 AK313583.1 BC002975.1 BC030210.1 BC032651.1 M80461.1 M89957.1 
    S52229.1 S79249.1 X83539.1 

    7 DOTS entries:

    DT.311555  DT.100754192  DT.95080712  DT.100020983  DT.120966709  DT.91744311  DT.95301786 

    Selected AceView cDNA sequences (see all 207):

    CR592092 CR617922 CR599571 BG392020 BG755705 BX336723 CR591997 S79249 
    CR618467 X83539 BM924097 CR623737 CR606875 AU105583 BX280250 AI239619 
    CR608074 BM920096 BI836408 AU099391 AL559878 CA415356 AY212253 BI521520 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD79B (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                                -     -     -                                             
    SP2:                                -     -     -                                             
    SP3:                                -     -     -     -     -                                 
    SP4:                                                                                          
    SP5:                                -                                                         


    ECgene alternative splicing isoforms for CD79B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD79B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD79B Expression
    About this image


    CD79B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Tonsil (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    CD79B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD79B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89575

    UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259
    Tissue specificity: B-cells

        Pathway & Disease-focused RT2 Profiler PCR Array including CD79B: 
              Cell Surface Markers in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD79B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD79B gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd79b1 , 5 CD79B antigen1, 5 75.04(n)1
    69.16(a)1
      11 (68.89 cM)5
    159851  NM_008339.21  NP_032365.11 
     1063113415 
    chicken
    (Gallus gallus)
    Aves CD79B1 CD79b molecule, immunoglobulin-associated beta 57.98(n)
    42.79(a)
      419940  NM_001006328.2  NP_001006328.2 


    ENSEMBL Gene Tree for CD79B (if available)
    TreeFam Gene Tree for CD79B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD79B (see all 212)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0578334
    Agammaglobulinemia 6, autosomal recessive (AGM6)4--see VAR_0578332 G S mis40--------
    rs110795151,2
    C,F,A,H--63023435(+) CCTACC/GCTCAG 3 -- ds500120Minor allele frequency- G:0.33NS EA NA WA CSA 1145
    rs733263111,2
    C,F--63023551(+) CAGGTG/CCTTTG 3 -- ds50012Minor allele frequency- C:0.04WA 120
    rs1496972241,2
    C--63023557(+) CTTTGA/GGAGGG 3 -- ds50010--------
    rs1454912051,2
    --63023607(+) TTTTCC/GGCTGA 3 -- ds50010--------
    rs1417542491,2
    --63023735(+) GGATGA/CGACCA 3 -- ds50010--------
    rs129466691,2
    C,F,A,H--63023797(+) ACCCTC/TGAGGG 3 -- ds500121Minor allele frequency- T:0.29NA NS EA WA CSA 2332
    rs1900276421,2
    --63023818(+) CCACAA/TTCAAA 3 -- ds50010--------
    rs1471010611,2
    C--63023878(+) TGCCAC/TGAGCC 3 -- ds50010--------
    rs79211,2
    C,F,H--63024049(-) GGAGCC/TGAGGG 3 -- ut31 ese327Minor allele frequency- T:0.22MN NA NS EA WA CSA 3286

    HapMap Linkage Disequilibrium report for CD79B (62006098 - 62009714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD79B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908684CNV Loss21882294
    nsv833511CNV Loss17160897
    nsv517272CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): CD79B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD79B
    DNA2.0 Custom Variant and Variant Library Synthesis for CD79B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147245   
    OMIM disorders: 612692  
    UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259
  • Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692]: A primary immunodeficiency characterized
    by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of
    B-cell development. Affected individuals develop severe infections in the first years of life. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 19 diseases for CD79B:    
    About MalaCards
    familial chronic lymphocytic leukemia    agammaglobulinemia 6    acquired immunodeficiency syndrome    agammaglobulinemia 3
    plasmacytoma    agammaglobulinemia    chronic lymphocytic leukemia    malt lymphoma
    myeloma    diffuse large b-cell lymphoma    multiple myeloma    hodgkin's lymphoma
    b-cell lymphomas    non-hodgkin lymphoma    tonsillitis    hepatitis b
    leukemia    hepatitis    hiv-1

    2 diseases from the University of Copenhagen DISEASES database for CD79B:
    Chronic lymphocytic leukemia     Lymphoma

    CD79B for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for CD79B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 61.8 7 10552962 (2), 10048429 (1), 10753858 (1), 9269755 (1)
    leukemia b-cell 56.2 4 10753858 (1), 10792036 (1)
    lymphocytic leukemia chronic b-cell 49.4 4 10753858 (1), 10792036 (1)
    leukaemia lymphocytic 45 2 10090943 (1), 16156858 (1)
    plasmacytoma 36.2 1 11907094 (1)
    myeloma 32.8 4 11504918 (1), 19187782 (1)
    lymphoma 28.1 4 20043832 (1), 7681402 (1)
    leukemia 15.3 2 10753858 (1), 9269755 (1)
    lymphoma b-cell 4.37 1 7887308 (1)
    aids 0 1 8032536 (1)

    Genetic Association Database (GAD): CD79B
    Human Genome Epidemiology (HuGE) Navigator: CD79B (8 documents)

    Export disorders for CD79B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD79B gene, integrated from 10 sources (see all 165):
    (articles sorted by number of sources associating them with CD79B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism. (PubMed id 7913081)1, 2, 9 Hashimoto S.... Gregersen P.K. (Immunogenetics 1994)
    2. The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes. (PubMed id 8419481)1, 2, 9 Hashimoto S.... Chiorazzi N. (J. Immunol. 1993)
    3. Isolation and chromosomal mapping of the human immunoglobulin- associated B29 gene (IGB). (PubMed id 8486355)1, 2, 9 Wood W.J. Jr.... Denny C.T. (Genomics 1993)
    4. Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. (PubMed id 1534761)1, 2, 9 Mueller B.S.... Terhorst C. (Eur. J. Immunol. 1992)
    5. Physical linkage of the B29/Ig-beta (CD79B) gene to the skeletal muscle, sodium-channel, and growth hormone genes in rat and human. (PubMed id 9545642)1, 3, 9 Nakazato S....Ono M. (Genomics 1998)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    8. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    9. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 974 HGNC: 1699 AceView: SCN4AandCD79B Ensembl:ENSG00000007312 euGenes: HUgn974
    ECgene: CD79B Kegg: 974 H-InvDB: CD79B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD79B Pharmacogenomics, SNPs, Pathways
    CD79Bbasehttp://bioinf.uta.fi/CD79Bbase/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD79B gene:
    Search GeneIP for patents involving CD79B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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