Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD79B Gene

protein-coding   GIFtS: 63
GCID: GC17M062006

CD79b Molecule, Immunoglobulin-Associated Beta

(Previous name: CD79B antigen (immunoglobulin-associated beta))
(Previous symbol: IGB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD79b Molecule, Immunoglobulin-Associated Beta1 2     Ig-beta2 3
IGB1 2 3 5     B-Cell-Specific Glycoprotein B292 3
B292 3 5     AGM62 5
CD79B Antigen (Immunoglobulin-Associated Beta)1 2     B-Cell Antigen Receptor Complex-Associated Protein Beta Chain2
Immunoglobulin-Associated B29 Protein2 3     CD79b Antigen3

External Ids:    HGNC: 16991   Entrez Gene: 9742   Ensembl: ENSG000000073127   OMIM: 1472455   UniProtKB: P402593   

Export aliases for CD79B gene to outside databases

Previous GC identifers: GC17M061643 GC17M064432 GC17M062346 GC17M062479 GC17M059359 GC17M057373


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD79B Gene:
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface
immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which
are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein
of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been
described. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD79B Gene: 
CD79B (CD79b molecule, immunoglobulin-associated beta) is a protein-coding gene. Diseases associated with CD79B include familial chronic lymphocytic leukemia, and agammaglobulinemia 6, and among its related super-pathways are BCR signaling pathway and Immune System. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259
Function: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the
B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late
endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which
phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation

Gene Wiki entry for CD79B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD79B gene promoter:
         HOXA9   HOXA9B   Elk-1   LUN-1   E47   Meis-1b   GATA-2   Hand1   SEF-1 (1)   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD79B promoter sequence
   Search SABiosciences Chromatin IP Primers for CD79B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD79B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23

CD79B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD79B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M062006:  view genomic region     (about GC identifiers)

Start:
62,006,098 bp from pter      End:
62,009,714 bp from pter
Size:
3,617 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259 (See protein sequence)
Recommended Name: B-cell antigen receptor complex-associated protein beta chain precursor  
Size: 229 amino acids; 26048 Da
Subunit: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where
the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface
immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR
has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal
transduction through the complex can also occur outside lipid rafts (By similarity)
1 PDB 3D structure from and Proteopedia for CD79B:
3KG5 (3D)    
Secondary accessions: Q53FS2 Q9BU06
Alternative splicing: 3 isoforms:  P40259-1   P40259-2   P40259-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD79B: NX_P40259

Explore proteomics data for CD79B at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40259

  • CD79B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD79B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000617.1  NP_001035022.1  NP_067613.1  

    ENSEMBL proteins: 
     ENSP00000376544   ENSP00000006750   ENSP00000245862  
    Reactome Protein details: P40259
    Human Recombinant Protein Products for CD79B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD79B
    OriGene Protein Over-expression Lysate for CD79B
    OriGene MassSpec for CD79B 
    OriGene Custom Protein Services for CD79B
    GenScript Custom Purified and Recombinant Proteins Services for CD79B
    Novus Biologicals CD79B Proteins
    Novus Biologicals CD79B Lysates
    Sino Biological Recombinant Protein for CD79B
    Sino Biological Cell Lysate for CD79B 
    ProSpec Recombinant Protein for CD79B
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane TAS--

    CD79B for ontologies           About GeneDecksing



    CD79B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD79B
    R&D Systems Antibodies for CD79B
    OriGene Antibodies for CD79B
    OriGene Custom Antibody Services for CD79B
    GenScript Custom Superior Antibodies Services for CD79B
    Novus Biologicals CD79B Antibodies
    Abcam antibodies for CD79B
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CD79B
    LSBio Antibodies in human, mouse, rat for CD79B 

    Assay Products for CD79B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD79B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD79B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR003110 Phos_immunorcpt_sig_ITAM
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P40259

    ProtoNet protein and cluster: P40259

    3 Blocks protein domains:
    IPB003110 Phosphorylated immunoreceptor signaling ITAM
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
    Similarity: Contains 1 ITAM domain


    CD79B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD79B_HUMAN, P40259
    Function: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the
    B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late
    endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which
    phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation

         Genatlas biochemistry entry for CD79B:
    cell differentiation antigen CD79B,expressed on B cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity IEA--
    GO:0005515protein binding ----
         
    CD79B for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Cd79b):
     cellular  hematopoietic system  immune system  no phenotypic analysis  normal 

    CD79B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD79B: Cd79btm1Mnz Cd79btm2.1Mnz Cd79btm2Mnz

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD79B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD79B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD79B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD79B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD79B
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CD79B:
    hsa-miR-593 hsa-miR-654-5p hsa-miR-3144-5p hsa-miR-541
    SwitchGear 3'UTR luciferase reporter plasmidCD79B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD79B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD79B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD79B
    Sirion Biotech Customized adenovirus for overexpression of CD79B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD79B (see all 18)
    OriGene ORF clones in mouse, rat for CD79B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CD79B (NM_000626)
    Sino Biological Human cDNA Clone for CD79B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD79B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD79B
    Sirion Biotech Customized lentivirus for stable overexpression of CD79B 
                         Customized lentivirus expression plasmids for stable overexpression of CD79B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD79B
    Search LifeMap BioReagents cell lines for CD79B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD79B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD79B About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Signal transduction IP3 signaling
    Signal transduction IP3 signaling0.92
    4Immune response NFAT in immune response
    Immune response NFAT in immune response0.90
    5Signaling by the B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CD79B
        Immune response BCR pathway
    Signal transduction IP3 signaling
    Immune response NFAT in immune response

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD79B (see all 6)
        Fc-Gamma-RIIB Signaling in B-Cells
    B-Cell Receptor Complex
    IP3 Pathway
    Phospholipase-C Pathway
    PI3K Signaling in B-Lymphocyte

    3 GeneGo (Thomson Reuters) Pathways for CD79B
        Immune response BCR pathway
    Signal transduction IP3 signaling
    Immune response NFAT in immune response

    2 BioSystems Pathways for CD79B
        B Cell Receptor Signaling Pathway
    BCR signaling pathway


    4        Reactome Pathways for CD79B
        Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
    Adaptive Immune System
    Immune System
    Signaling by the B Cell Receptor (BCR)


    1         Kegg Pathway  (Kegg details for CD79B):
        B cell receptor signaling pathway


    CD79B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD79B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for CD79B (P402593 ENSP000003765444) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BLKP514513, ENSP000002590894I2D: score=3 STRING: ENSP00000259089
    CD19P153913, ENSP000003134194I2D: score=3 STRING: ENSP00000313419
    CD79AP119123, ENSP000002219724I2D: score=3 STRING: ENSP00000221972
    SYKP434053, ENSP000003648984I2D: score=3 STRING: ENSP00000364898
    CD3EP077663, ENSP000003545664I2D: score=2 STRING: ENSP00000354566
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS8486355
    GO:0007165signal transduction TAS8486355
    GO:0007166cell surface receptor signaling pathway ----
    GO:0050853B cell receptor signaling pathway IEA--

    CD79B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD79B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD79B

    8 Novoseek inferred chemical compound relationships for CD79B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 64.9 48 7592958 (4), 8559152 (2), 7524079 (2), 8125135 (2) (see all 28)
    digitonin 47.6 1 1386314 (1)
    phosphotyrosine 30.1 1 8765045 (1)
    phosphoinositide 28.2 2 12459553 (2)
    calcium 12.5 4 7509805 (1), 8262964 (1), 7688784 (1)
    phosphatidylinositol 7.4 2 1373499 (1), 8419471 (1)
    threonine 0 1 10900006 (1)
    serine 0 1 10900006 (1)

    Search CenterWatch for drugs/clinical trials and news about CD79B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD79B gene (3 alternative transcripts): 
    NM_000626.2  NM_001039933.1  NM_021602.2  

    Unigene Cluster for CD79B:

    CD79b molecule, immunoglobulin-associated beta
    Hs.89575  [show with all ESTs]
    Unigene Representative Sequence: AK223210
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392795 ENST00000006750(uc002jdp.1 uc002jdq.1 uc002jdr.1)
    ENST00000559358 ENST00000349817 ENST00000558969 ENST00000583260
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD79B
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CD79B:
    hsa-miR-593 hsa-miR-654-5p hsa-miR-3144-5p hsa-miR-541
    SwitchGear 3'UTR luciferase reporter plasmidCD79B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD79B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD79B
    Clone
    Products:
         
    OriGene clones in human, mouse for CD79B (see all 18)
    OriGene ORF clones in mouse, rat for CD79B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CD79B (NM_000626)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD79B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD79B
    Sirion Biotech Customized lentivirus for stable overexpression of CD79B 
                         Customized lentivirus expression plasmids for stable overexpression of CD79B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD79B
    OriGene qSTAR qPCR primer pairs in human, mouse for CD79B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD79B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD79B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD79B

    Additional mRNA sequence: 

    AK222954.1 AK223210.1 AK313583.1 BC002975.1 BC030210.1 BC032651.1 M80461.1 M89957.1 
    S52229.1 S79249.1 X83539.1 

    7 DOTS entries:

    DT.311555  DT.100754192  DT.95080712  DT.100020983  DT.120966709  DT.91744311  DT.95301786 

    24/207 AceView cDNA sequences (see all 207):

    CR592092 AI239619 BI836408 CA415356 CR608074 BG392020 AU105583 AY212253 
    BX280250 CR591997 AU099391 AL559878 CR618467 CR599571 X83539 CR606875 
    S79249 BM924097 CR623737 BG755705 BM920096 CR617922 BX336723 BG755302 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CD79B (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                                -     -     -                                             
    SP2:                                -     -     -                                             
    SP3:                                -     -     -     -     -                                 
    SP4:                                                                                          
    SP5:                                -                                                         


    ECgene alternative splicing isoforms for CD79B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD79B expression in normal human tissues (normalized intensities)      CD79B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD79B Expression
    About this image


    CD79B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Lymph (Hematopoietic System)    fully expand to see all 3 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             CD19+ B Cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   
     
     Liver (Hepatobiliary System)
             Fetal Liver CD34+ Cells   

    See CD79B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD79B

    SOURCE GeneReport for Unigene cluster: Hs.89575

    UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259
    Tissue specificity: B-cells

        SABiosciences Expression via Pathway-Focused PCR Array including CD79B: 
              Cell Surface Markers in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD79B
    OriGene qSTAR qPCR primer pairs in human, mouse for CD79B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD79B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD79B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD79B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD79B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD79B gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd79b1 , 5 CD79B antigen1, 5 75.62(n)1
    69.6(a)1
      11 (68.89 cM)5
    159851  NM_008339.21  NP_032365.11 
     1063113415 
    chicken
    (Gallus gallus)
    Aves CD79B1 CD79b molecule, immunoglobulin-associated beta 57.72(n)
    43.06(a)
      419940  NM_001006328.2  NP_001006328.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cd79b6
    CD79b molecule, immunoglobulin-associated beta
    23(a)
    1 ↔ 1
    12(5951071-5957014)


    ENSEMBL Gene Tree for CD79B (if available)
    TreeFam Gene Tree for CD79B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/212 SNPs in CD79B are shown (see all 212)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0578334
    Agammaglobulinemia 6, autosomal recessive (AGM6)4--see VAR_0578332 G S mis40--------
    rs110795151,2
    C,F,A,H--63023435(+) CCTACC/GCTCAG 3 -- ds500120Minor allele frequency- G:0.33NS EA NA WA CSA 1145
    rs733263111,2
    C,F--63023551(+) CAGGTG/CCTTTG 3 -- ds50012Minor allele frequency- C:0.04WA 120
    rs1496972241,2
    C--63023557(+) CTTTGA/GGAGGG 3 -- ds50010--------
    rs1454912051,2
    --63023607(+) TTTTCC/GGCTGA 3 -- ds50010--------
    rs1417542491,2
    --63023735(+) GGATGA/CGACCA 3 -- ds50010--------
    rs129466691,2
    C,F,A,H--63023797(+) ACCCTC/TGAGGG 3 -- ds500121Minor allele frequency- T:0.29NA NS EA WA CSA 2332
    rs1900276421,2
    --63023818(+) CCACAA/TTCAAA 3 -- ds50010--------
    rs1471010611,2
    C--63023878(+) TGCCAC/TGAGCC 3 -- ds50010--------
    rs79211,2
    C,F,H--63024049(-) GGAGCC/TGAGGG 3 -- ut31 ese327Minor allele frequency- T:0.22MN NA NS EA WA CSA 3286

    HapMap Linkage Disequilibrium report for CD79B (62006098 - 62009714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD79B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908684CNV Loss21882294
    nsv833511CNV Loss17160897
    nsv517272CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): CD79B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD79B
    DNA2.0 Custom Variant and Variant Library Synthesis for CD79B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147245   
    OMIM disorders: 612692  
    UniProtKB/Swiss-Prot: CD79B_HUMAN, P40259
  • Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692]: A primary immunodeficiency characterized
    by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of
    B-cell development. Affected individuals develop severe infections in the first years of life. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 16 diseases for CD79B:    About MalaCards
    familial chronic lymphocytic leukemia    agammaglobulinemia 6    acquired immunodeficiency syndrome    chronic lymphocytic leukemia
    plasmacytoma    agammaglobulinemia    myeloma    diffuse large b-cell lymphoma
    malt lymphoma    b-cell lymphomas    multiple myeloma    hodgkin's lymphoma
    non-hodgkin lymphoma    leukemia    hepatitis b    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for CD79B:
    Chronic lymphocytic leukemia     Lymphoma

    CD79B for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for CD79B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 61.8 7 10552962 (2), 10048429 (1), 10753858 (1), 9269755 (1)
    leukemia b-cell 56.2 4 10753858 (1), 10792036 (1)
    lymphocytic leukemia chronic b-cell 49.4 4 10753858 (1), 10792036 (1)
    leukaemia lymphocytic 45 2 10090943 (1), 16156858 (1)
    plasmacytoma 36.2 1 11907094 (1)
    myeloma 32.8 4 11504918 (1), 19187782 (1)
    lymphoma 28.1 4 20043832 (1), 7681402 (1)
    leukemia 15.3 2 10753858 (1), 9269755 (1)
    lymphoma b-cell 4.37 1 7887308 (1)
    aids 0 1 8032536 (1)

    Genetic Association Database (GAD): CD79B
    Human Genome Epidemiology (HuGE) Navigator: CD79B (8 documents)

    Export disorders for CD79B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD79B gene, integrated from 9 sources (see all 164):
    (articles sorted by number of sources associating them with CD79B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism. (PubMed id 7913081)1, 2, 9 Hashimoto S.... Gregersen P.K. (1994)
    2. The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes. (PubMed id 8419481)1, 2, 9 Hashimoto S.... Chiorazzi N. (1993)
    3. Isolation and chromosomal mapping of the human immunoglobulin- associated B29 gene (IGB). (PubMed id 8486355)1, 2, 9 Wood W.J. Jr.... Denny C.T. (1993)
    4. Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. (PubMed id 1534761)1, 2, 9 Mueller B.S.... Terhorst C. (1992)
    5. Physical linkage of the B29/Ig-beta (CD79B) gene to the skeletal muscle, sodium-channel, and growth hormone genes in rat and human. (PubMed id 9545642)1, 3, 9 Nakazato S....Ono M. (1998)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    8. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    9. Common genetic variants in candidate genes and risk o f familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 974 HGNC: 1699 AceView: SCN4AandCD79B Ensembl:ENSG00000007312 euGenes: HUgn974
    ECgene: CD79B Kegg: 974 H-InvDB: CD79B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD79B Pharmacogenomics, SNPs, Pathways
    CD79Bbasehttp://bioinf.uta.fi/CD79Bbase/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD79B gene:
    Search GeneIP for patents involving CD79B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CD79B
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CD79B (CD79B)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CD79B   OriGene RNAi products in human, mouse, rat for CD79B  
     OriGene qPCR primer pairs and template standards for CD79B   OriGene Protein Over-expression Lysate for CD79B  
     OriGene MassSpec something-or-other for CD79B   OriGene clones in human, mouse for CD79B  
     OriGene qSTAR qPCR primer pairs in human, mouse for CD79B   OriGene Purified Protein for CD79B  
     OriGene ORF clones in mouse, rat for CD79B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD79B   OriGene Custom Protein Services for CD79B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD79B
     QIAGEN SeqTarget long-range PCR primers for resequencing CD79B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD79B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD79B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD79B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD79B
     GenScript Custom Purified and Recombinant Proteins Services for CD79B GenScript cDNA clones with any tag delivered in your preferred vector for CD79B
     GenScript Custom Assay Services for CD79B GenScript Custom Superior Antibodies Services for CD79B
     GenScript Custom overexpressing Cell Line Services for CD79B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CD79B promoter
     Search Chromatin IP Primers for CD79B
     RT2 qPCR Primer Assay in human, mouse, rat CD79B
     GNC Network for CD79B
     SABiosciences PCR Arrays including human, mouse, rat CD79B
     Search Tocris compounds for CD79B
     Proteins and Antibodies for CD79B
     Cell Lysates for CD79B
     cDNA Clones for CD79B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CD79B antibodies
     CD79B proteins
     CD79B lysates
     Antibodies for CD79B
     See all of Abcam's Antibodies, Kits and Proteins for CD79B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CD79B




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CD79B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD79B
     SwitchGear 3'UTR luciferase reporter plasmids for CD79B
     SwitchGear Promoter luciferase reporter plasmids for CD79B
     ThermoFisher Antibodies for CD79B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD79B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CD79B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD79B
    Customized:
     lentivirus for stable overexpression of CD79B
     lentivirus expression plasmids for stable overexpression of CD79B
     adenovirus for overexpression of CD79B
     LSBio Antibodies in human, mouse, rat for CD79B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CD79B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4