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Aliases for CD79B Gene

Aliases for CD79B Gene

  • CD79b Molecule 2 3 5
  • CD79B Antigen (Immunoglobulin-Associated Beta) 2 3
  • CD79b Molecule, Immunoglobulin-Associated Beta 2 3
  • Immunoglobulin-Associated B29 Protein 3 4
  • B-Cell-Specific Glycoprotein B29 3 4
  • Ig-Beta 3 4
  • IGB 3 4
  • B29 3 4
  • B-Cell Antigen Receptor Complex-Associated Protein Beta Chain 3
  • CD79b Antigen 4
  • AGM6 3

External Ids for CD79B Gene

Previous HGNC Symbols for CD79B Gene

  • IGB

Previous GeneCards Identifiers for CD79B Gene

  • GC17M061643
  • GC17M064432
  • GC17M062346
  • GC17M062479
  • GC17M059359
  • GC17M062006
  • GC17M057373

Summaries for CD79B Gene

Entrez Gene Summary for CD79B Gene

  • The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD79B Gene

CD79B (CD79b Molecule) is a Protein Coding gene. Diseases associated with CD79B include Agammaglobulinemia 6 and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Phospholipase-C Pathway and Development Angiotensin activation of ERK. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for CD79B Gene

  • Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Gene Wiki entry for CD79B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD79B Gene

Genomics for CD79B Gene

Regulatory Elements for CD79B Gene

Enhancers for CD79B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G063930 1.4 Ensembl ENCODE dbSUPER 19.8 +0.8 754 3.2 ELF3 HDGF WRNIP1 YBX1 ZNF121 EGR1 RELB IKZF2 JUNB ELF1 FTSJ3 CD79B CSH2 GH1
GH17G063987 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -56.5 -56465 2.0 HNRNPUL1 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 CD79B GH1 CSHL1 SCN4A ENSG00000263489 PIR61137
GH17G063927 1.2 FANTOM5 ENCODE dbSUPER 20.1 +4.4 4411 1.1 KLF1 BHLHE40 NFXL1 EBF1 POLR2A ZNF341 GABPB1 IKZF1 EED IKZF2 FTSJ3 CD79B SCN4A GH1
GH17G064059 2 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -131.9 -131907 9.5 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B ZBTB7B ZNF766 CBX5 ZNF143 ERN1 GH1 CSHL1 DDX5 SCN4A SNORD104 CD79B MAP3K3 LIMD2 ICAM2
GH17G063982 1.5 Ensembl ENCODE dbSUPER 13.2 -52.2 -52233 3.3 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 ZBTB7B ZNF766 ZNF207 FOS CD79B GH1 CSHL1 ICAM2 PRR29 ARHGAP27P1-BPTFP1-KPNA2P3 PSMC5 ENSG00000263489 PIR61137
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD79B on UCSC Golden Path with GeneCards custom track

Genomic Location for CD79B Gene

Chromosome:
17
Start:
63,928,738 bp from pter
End:
63,932,354 bp from pter
Size:
3,617 bases
Orientation:
Minus strand

Genomic View for CD79B Gene

Genes around CD79B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD79B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD79B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD79B Gene

Proteins for CD79B Gene

  • Protein details for CD79B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40259-CD79B_HUMAN
    Recommended name:
    B-cell antigen receptor complex-associated protein beta chain
    Protein Accession:
    P40259
    Secondary Accessions:
    • Q53FS2
    • Q9BU06

    Protein attributes for CD79B Gene

    Size:
    229 amino acids
    Molecular mass:
    26048 Da
    Quaternary structure:
    • Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity).

    Three dimensional structures from OCA and Proteopedia for CD79B Gene

    Alternative splice isoforms for CD79B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD79B Gene

Post-translational modifications for CD79B Gene

  • Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.
  • Glycosylation at Asn73, posLast=101101, posLast=127127, and posLast=128128
  • Modification sites at PhosphoSitePlus

Other Protein References for CD79B Gene

No data available for DME Specific Peptides for CD79B Gene

Domains & Families for CD79B Gene

Gene Families for CD79B Gene

Suggested Antigen Peptide Sequences for CD79B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD79B: view

No data available for UniProtKB/Swiss-Prot for CD79B Gene

Function for CD79B Gene

Molecular function for CD79B Gene

GENATLAS Biochemistry:
cell differentiation antigen CD79B,expressed on B cells
UniProtKB/Swiss-Prot Function:
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Gene Ontology (GO) - Molecular Function for CD79B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IMP 14967045
genes like me logo Genes that share ontologies with CD79B: view
genes like me logo Genes that share phenotypes with CD79B: view

Human Phenotype Ontology for CD79B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD79B Gene

MGI Knock Outs for CD79B:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD79B

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD79B

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CD79B Gene

Localization for CD79B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD79B Gene

Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD79B gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 5
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for CD79B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CD79B: view

Pathways & Interactions for CD79B Gene

genes like me logo Genes that share pathways with CD79B: view

SIGNOR curated interactions for CD79B Gene

Activates:

Gene Ontology (GO) - Biological Process for CD79B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006955 immune response TAS 8486355
GO:0007165 signal transduction TAS 8486355
GO:0007166 cell surface receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with CD79B: view

Drugs & Compounds for CD79B Gene

(4) Drugs for CD79B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CD79B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD79B: view

Transcripts for CD79B Gene

Unigene Clusters for CD79B Gene

CD79b molecule, immunoglobulin-associated beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD79B

Alternative Splicing Database (ASD) splice patterns (SP) for CD79B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4:
SP5: -
SP6:

Relevant External Links for CD79B Gene

GeneLoc Exon Structure for
CD79B
ECgene alternative splicing isoforms for
CD79B

Expression for CD79B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD79B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD79B Gene

This gene is overexpressed in Spleen (x12.6), Whole Blood (x7.6), Pituitary (x5.0), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for CD79B Gene

This gene is overexpressed in Blymphocyte (36.0), Monocytes (16.0), and Lymph node (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD79B Gene



Protein tissue co-expression partners for CD79B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD79B Gene:

CD79B

SOURCE GeneReport for Unigene cluster for CD79B Gene:

Hs.89575

mRNA Expression by UniProt/SwissProt for CD79B Gene:

P40259-CD79B_HUMAN
Tissue specificity: B-cells.

Evidence on tissue expression from TISSUES for CD79B Gene

  • Spleen(4.6)
  • Intestine(4.3)
  • Lymph node(3.1)
  • Blood(2.8)
  • Bone marrow(2.8)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD79B Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • meninges
  • middle ear
  • mouth
  • neck
  • outer ear
  • sinus
  • skull
Thorax:
  • bronchus
  • chest wall
  • clavicle
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • biliary tract
  • gallbladder
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
Pelvis:
  • pelvis
  • rectum
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with CD79B: view

Primer Products

Orthologs for CD79B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD79B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD79B 34 35
  • 98.98 (n)
dog
(Canis familiaris)
Mammalia CD79B 34 35
  • 80.59 (n)
cow
(Bos Taurus)
Mammalia CD79B 34 35
  • 77.94 (n)
rat
(Rattus norvegicus)
Mammalia Cd79b 34
  • 75.92 (n)
mouse
(Mus musculus)
Mammalia Cd79b 34 16 35
  • 75.04 (n)
oppossum
(Monodelphis domestica)
Mammalia CD79b 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD79B 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD79B 34 35
  • 57.98 (n)
Species where no ortholog for CD79B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD79B Gene

ENSEMBL:
Gene Tree for CD79B (if available)
TreeFam:
Gene Tree for CD79B (if available)

Paralogs for CD79B Gene

No data available for Paralogs for CD79B Gene

Variants for CD79B Gene

Sequence variations from dbSNP and Humsavar for CD79B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs121912424 Pathogenic, Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692] 63,930,095(-) GCTGC(A/G)GCACA intron-variant, reference, missense
rs267606711 Pathogenic 63,930,266(-) GGAAG(C/T)AGGAG intron-variant, reference, stop-gained
rs144755516 untested 63,930,325(+) TCACC(A/G)TGAAG intron-variant, reference, missense
rs147194821 untested 63,929,822(+) GCAGC(A/G)TCTGG reference, missense
rs200126941 untested 63,930,286(+) TCACA(G/T)TGCCG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD79B Gene

Variant ID Type Subtype PubMed ID
nsv517272 CNV gain+loss 19592680
nsv833511 CNV loss 17160897

Variation tolerance for CD79B Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD79B Gene

Human Gene Mutation Database (HGMD)
CD79B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD79B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD79B Gene

Disorders for CD79B Gene

MalaCards: The human disease database

(6) MalaCards diseases for CD79B Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
agammaglobulinemia 6
  • agammaglobulinemia 6, autosomal recessive
agammaglobulinemia, non-bruton type
  • autosomal agammaglobulinemia
agammaglobulinemia
  • hypogammaglobulinemia
ecthyma
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search CD79B in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD79B_HUMAN
  • Agammaglobulinemia 6, autosomal recessive (AGM6) [MIM:612692]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269 PubMed:17675462}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CD79B

Genetic Association Database (GAD)
CD79B
Human Genome Epidemiology (HuGE) Navigator
CD79B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD79B
genes like me logo Genes that share disorders with CD79B: view

No data available for Genatlas for CD79B Gene

Publications for CD79B Gene

  1. Physical linkage of the B29/Ig-beta (CD79B) gene to the skeletal muscle, sodium-channel, and growth hormone genes in rat and human. (PMID: 9545642) Nakazato S. … Ono M. (Genomics 1998) 2 3 22 64
  2. The complete sequence of the human CD79b (Ig beta/B29) gene: identification of a conserved exon/intron organization, immunoglobulin-like regulatory regions, and allelic polymorphism. (PMID: 7913081) Hashimoto S. … Gregersen P.K. (Immunogenetics 1994) 3 4 22 64
  3. The human Ig-beta cDNA sequence, a homologue of murine B29, is identical in B cell and plasma cell lines producing all the human Ig isotypes. (PMID: 8419481) Hashimoto S. … Chiorazzi N. (J. Immunol. 1993) 3 4 22 64
  4. Isolation and chromosomal mapping of the human immunoglobulin- associated B29 gene (IGB). (PMID: 8486355) Wood W.J. Jr. … Denny C.T. (Genomics 1993) 3 4 22 64
  5. Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. (PMID: 1534761) Mueller B.S. … Terhorst C. (Eur. J. Immunol. 1992) 3 4 22 64

Products for CD79B Gene

  • Addgene plasmids for CD79B

Sources for CD79B Gene

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