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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD79A Gene

protein-coding GIFtS: 64
GCID: GC19P042381

CD79a molecule, immunoglobulin-associated alpha

(Previous name: CD79A antigen (immunoglobulin-associated alpha) )
(Previous symbol: IGA)

Explore 374 diseases affiliated with
CD79A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD79a Molecule, Immunoglobulin-Associated Alpha¹ ²		MB-1 Membrane Glycoprotein² ³
IGA¹ ² ³ ⁵		B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain²
MB-1¹ ²		Ig-Alpha¹
CD79A Antigen (Immunoglobulin-Associated Alpha)¹ ²		Ig-Alpha¹
Membrane-Bound Immunoglobulin-Associated Protein² ³		MB1³
Surface IgM-Associated Protein² ³		CD79a Antigen³

External Ids:	HGNC: 1698¹	Entrez Gene: 973²	Ensembl: ENSG00000105369⁷	OMIM: 112205⁵	UniProtKB: P11912³

Export aliases for CD79A gene to outside databases

Previous GC identifers: GC19P043020 GC19P042773 GC19P047057 GC19P047073 GC19P038812

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD79A:

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface

immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are

necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the

B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD79A_HUMAN, P11912

Function: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of

antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to

late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of

pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity

with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family

tyrosine kinases. Represses BCR signaling during development of immature B-cells

Gene Wiki entry for CD79A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD79A gene promoter:
p53 c-Myb MyoD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD79A promoter sequence

Search SABiosciences Chromatin IP Primers for CD79A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD79A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

CD79A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD79A gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P042381: view genomic region (about GC identifiers)

Start:	42,381,190 bp from pter	End:	42,385,439 bp from pter
Size:	4,250 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD79A_HUMAN, P11912 (See protein sequence)

Recommended Name: B-cell antigen receptor complex-associated protein alpha chain precursor

Size: 226 amino acids; 25038 Da

Subunit: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the

alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface

immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2

domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on

Tyr-210, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate

BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases

including FYN and LYN, increasing their activity (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has

been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal

transduction through the complex can also occur outside lipid rafts (By similarity)

1 PDB 3D structure from and Proteopedia for CD79A:

1CV9 (3D)

Secondary accessions: A0N775 Q53FB8

Alternative splicing: 2 isoforms: P11912-1 P11912-2

Explore the universe of human proteins at neXtProt for CD79A: NX_P11912

Post-translational modifications:

Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues

by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines

serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to

phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may

prevent subsequent tyrosine phosphorylation¹

Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B cell

differentiation (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11912

CD79A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001774.1 NP_067612.1

ENSEMBL proteins:

ENSP00000221972 ENSP00000400605

Reactome Protein details: P11912
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	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005771	multivesicular body	ISS	--
GO:0005886	plasma membrane	TAS	--
GO:0009897	external side of plasma membrane	ISS	--
GO:0016021	integral to membrane	IEA	--
GO:0019815	B cell receptor complex	ISS	--

CD79A for ontologies About GeneDecksing

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Assay Products for CD79A:

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	GenScript Custom Assay Services for CD79A
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD79A for domains About GeneDecksing

5 InterPro domains/families:

IPR003598 Ig_sub2

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR003110 Phos_immunorcpt_sig_ITAM

IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry P11912

ProtoNet protein and cluster: P11912

4 Blocks protein families:

IPB003110 Phosphorylated immunoreceptor signaling ITAM

IPB003598 Immunoglobulin C-2 type

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: CD79A_HUMAN, P11912

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 ITAM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD79A_HUMAN, P11912

Function: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of

antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to

late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of

pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity

with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family

tyrosine kinases. Represses BCR signaling during development of immature B-cells

Genatlas biochemistry entry for CD79A:

Ig alpha component (47kDa),B cell Ag receptor,mouse mb-1 homolog (Ig-alpha/mb-1)

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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CD79A:
		hsa-miR-34c-3p hsa-miR-485-5p hsa-miR-885-3p hsa-miR-1827 hsa-miR-3153 hsa-miR-34a*
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD79A

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	IEA	--
GO:0005515	protein binding	--	--

CD79A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CD79A:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for CD79A: Cd79a^tm2Pld Cd79a^tm4.1Cgn Cd79a^tm5.1Cgn
8 MGI mutant phenotypes (inferred from 18 alleles) (MGI details for Cd79a):

cellular	hematopoietic system	homeostasis/metabolism	immune system	nervous system
no phenotypic analysis	normal	renal/urinary system

CD79A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

B cell receptor signaling pathway

	B cell receptor signaling pathway	1.00			PI3K Signaling in B-Lymphocyte	0.35
	BCR signaling pathway	0.41

Assembly of Signalosomes at the Activated BCR

	Assembly of Signalosomes at the Activated BCR	1.00			Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)	0.45
	Antigen Activates B Cell Receptor Leading to Generation of Second Messengers	0.78

Immune response_NFAT in immune response

Immune response_NFAT in immune response

1.00

Immune response NFAT in immune response

0.91

Signal transduction_IP3 signaling

Signal transduction_IP3 signaling

1.00

Signal transduction IP3 signaling

0.92

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CD79A

	Immune response BCR pathway
	Signal transduction IP3 signaling
	Immune response NFAT in immune response

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD79A (see all 6)

	Fc-Gamma-RIIB Signaling in B-Cells
	B-Cell Receptor Complex
	IP3 Pathway
	Phospholipase-C Pathway
	PI3K Signaling in B-Lymphocyte

1 Cell Signaling Technology (CST) Pathway for CD79A

Lymphocyte Signaling

3 GeneGo (Thomson Reuters) Pathways for CD79A

	Immune response BCR pathway
	Signal transduction IP3 signaling
	Immune response NFAT in immune response

2 BioSystems Pathways for CD79A

	B Cell Receptor Signaling Pathway
	BCR signaling pathway

5/6 Reactome Pathways for CD79A (see all 6)

	Assembly of Signalosomes at the Activated BCR
	Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
	Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
	Adaptive Immune System
	Immune System

2 Kegg Pathways (Kegg details for CD79A):

	B cell receptor signaling pathway
	Primary immunodeficiency

CD79A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD79A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for CD79A (P11912^{2, 3} ENSP00000221972⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FN1	P02751²^,³, ENSP00000346839⁴	MINT-6491150 I2D: score=1 STRING: ENSP00000346839
CD19	P15391³, ENSP00000313419⁴	I2D: score=3 STRING: ENSP00000313419
SYK	P43405³, ENSP00000364898⁴	I2D: score=3 STRING: ENSP00000364898
CD5	P06127³, ENSP00000342681⁴	I2D: score=2 STRING: ENSP00000342681
FYN	P06241³, ENSP00000357656⁴	I2D: score=2 STRING: ENSP00000357656

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030183	B cell differentiation	ISS	--
GO:0042100	B cell proliferation	ISS	--
GO:0042113	B cell activation	ISS	--
GO:0050853	B cell receptor signaling pathway	ISS	--

CD79A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD79A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD79A
10/124 Novoseek chemical compound relationships for CD79A gene (see all 124) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gliadin	86	224	8311090 (5), 15355487 (4), 11144436 (3), 8937757 (3) (see all 99)
gluten	76.3	80	2311308 (6), 2320948 (6), 15355487 (4), 17364503 (3) (see all 45)
unicap	50.8	4	20181654 (1), 11329459 (1), 19584951 (1), 20016199 (1)
cardiolipin	50.8	17	7699683 (2), 10689008 (1), 11795690 (1), 18789008 (1) (see all 14)
sulfolipid i	50.4	4	12354881 (2), 14715547 (1)
ivig	47.3	28	9741353 (2), 7523434 (1), 17999675 (1), 1628130 (1) (see all 17)
reticulin	47.1	8	15082580 (1), 8201496 (1), 7535982 (1), 10563541 (1) (see all 8)
creatinine	45.8	78	10556477 (3), 2046826 (2), 2105638 (1), 2113220 (1) (see all 57)
gamma globulin	45.8	4	9649200 (2), 2334858 (1)
neopterin	43.1	23	9028411 (3), 1967191 (2), 9219059 (2), 8925815 (1) (see all 18)

Search CenterWatch for drugs/clinical trials and news about CD79A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD79A gene (2 alternative transcripts):

NM_001783.3 NM_021601.3

Unigene Cluster for CD79A:

CD79a molecule, immunoglobulin-associated alpha

Hs.631567 [show with all ESTs]

Unigene Representative Sequence: AK223371

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000221972(uc002orv.3) ENST00000444740(uc002oru.3)

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Additional cDNA sequence:

AK223371.1 AK315337.1 BC018964.2 BC113731.1 BC113733.1 M74721.1 M80462.1 M86921.1

S46706.1 S75217.1 S79248.1 X13451.1 X83540.1

8 DOTS entries:

DT.95362928 DT.446838 DT.100863315 DT.121409221 DT.121409220 DT.92439847 DT.95362925 DT.95362935

24/261 AceView cDNA sequences (see all 261):

BM927669 BQ060823 BQ059168 BF794319 CR617518 BE396686 BG758434 AA306502

BM477238 BG685198 BX115495 S79248 BQ707323 BM914306 BE267912 BQ064095

BG025513 X83540 BQ057216 AA687459 BQ185363 T87012 CR600210 BQ004795

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CD79A About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b
SP1:							-
SP2:					-		-
SP3:

ECgene alternative splicing isoforms for CD79A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD79A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGAGGGCA

About this image

CD79A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Umbilical Cord

Wharton's Jelly

Umbilical Cord Mesenchymal Stem Cells

Extraembryonic Tissues, Umbilical Cord

Adipose

Body Subcutaneous White Adipose

Adipose

Thoracic Perivascular Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CD79A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD79A

SOURCE GeneReport for Unigene cluster: Hs.631567

UniProtKB/Swiss-Prot: CD79A_HUMAN, P11912

Tissue specificity: B-cells

SABiosciences Expression via Pathway-Focused PCR Arrays including CD79A:

Cell Surface Markers in human mouse rat

Cell Lineage Identification in human mouse rat

Terminal Differentiation Markers in human mouse rat

Lymphoma in human mouse rat

T-cell & B-cell Activation in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD79A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD79A gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd79a^{1 , 5}	CD79A antigen (immunoglobulin-associated alpha)^{1, 5}	74.55(n)¹ 70.91(a)¹		7 (13.49 cM)⁵ 12518¹ NM_007655.3¹ NP_031681.2¹ 24897381⁵
lizard (Anolis carolinensis)	Reptilia	CD79A⁶	--	43(a)	1 ↔ 1	AAWZ02038666(866-7865)
zebrafish (Danio rerio)	Actinopterygii	LOC798792¹	b-cell antigen receptor complex-associated protein more	49.35(n) 37.75(a)		798792 XM_001339187.1 XP_001339223.1

ENSEMBL Gene Tree for CD79A (if available)
TreeFam Gene Tree for CD79A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11881346^1,2	C,H,	--	38810787(+)	`aaagcA/Gagact`	2	--	us2k¹		1	NA	2
rs75643913^1,2	F,	--	38812543(+)	`GCGAGG/AGCCAC`	2	--	ut5¹		1	WA	118
rs76625225^1,2	F	--	38812793(+)	`GCAGAG/CAGGGC`	2	--	int¹		1	NA	4
rs112580282^1,2	C,	--	38813598(+)	`CACATT/ACAACT`	2	--	int¹		1	NA	2
rs74392757^1,2	C,F,	--	38813634(+)	`GGTCAC/TAGGCC`	2	--	int¹		1	WA	118
rs79326528^1,2	C,F,	--	38814016(+)	`GTATGC/TGGGAG`	2	--	int¹		1	WA	118
rs11880116^1,2	C,F,H,	--	38814122(+)	`CACCCC/TAACCA`	2	--	int¹		3	NA CSA WA	124
rs113019286^1,2	F	--	38814570(+)	`GGCATG/ATACGT`	3	/I /M	int¹ mis¹		2	CSA	6
rs11539391^1,2	H	--	38814949(+)	`AGCCGA/GGGGGA`	4	E G	mis¹ ese³		4	NS EA	398
rs113506927^1,2		--	38815072(+)	`CCAGGC/TAGCCC`	2	--	int¹		1	CSA	1

HapMap Linkage Disequilibrium report for CD79A (42381190 - 42385439 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD79A: --
Human Gene Mutation Database (HGMD): CD79A

Locus Specific Mutation Databases (LSDB): CD79A

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD79A

DNA2.0 Custom Variant and Variant Library Synthesis for CD79A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD79A for disorders           About GeneDecksing

OMIM gene information: 112205
OMIM disorders: 613501
UniProtKB/Swiss-Prot: CD79A_HUMAN, P11912

Defects in CD79A are the cause of agammaglobulinemia type 3 (AGM3) [MIM:613501]. It is a primary

immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due

to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Note=Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for

exon 3, have been identified. Both mutations give rise to a truncated protein

20/374 diseases for CD79A (see all 374): About MalaCards

subcorneal pustular dermatosis henoch-schoenlein purpura epidermolysis bullosa acquisita protein-losing enteropathy

erythema elevatum diutinum pure red-cell aplasia monoclonal gammopathy of undetermined significance heparin-induced thrombocytopenia

marginal zone b-cell lymphoma protein-energy malnutrition exercise induced anaphylaxis tabes dorsalis

dandy-walker syndrome epidermolysis bullosa acute poststreptococcal glomerulonephritis necrobiotic xanthogranuloma

isolated growth hormone deficiency natural killer cell leukemia common variable immunodeficiency chiari malformation

20/95 diseases from the University of Copenhagen DISEASES database for CD79A (see all 95):

Nephritis Celiac disease Immunoglobulin alpha deficiency Myeloma

Cholera Dermatitis Proteinuria Lymphoma

Diarrhea Agammaglobulinemia Influenza Rheumatoid arthritis

Vasculitis Nephrotic syndrome Nasopharynx carcinoma Toxoplasmosis

Systemic lupus erythematosus Henoch-Schoenlein purpura Epidermolysis bullosa acquisita Pneumonia

10/93 Novoseek disease relationships for CD79A gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nephropathy iga	95.2	2762	11532693 (11), 10213640 (11), 12955676 (10), 17074110 (10) (see all 99)
iga deficiency	91.7	509	17362578 (10), 2093881 (9), 16631941 (7), 20101521 (7) (see all 99)
iga deficiency selective	83.6	132	15086392 (5), 7892814 (4), 9852751 (4), 15711951 (3) (see all 61)
celiac disease	82.8	125	9931524 (5), 16131987 (4), 8565771 (3), 8885812 (3) (see all 82)
hyper-igm syndrome	78.2	21	7964460 (1), 17303928 (1), 19266080 (1), 16311023 (1) (see all 18)
igg subclass deficiency	74.8	31	15864886 (6), 17338791 (6), 8385798 (2), 12144642 (2) (see all 10)
glomerulonephritis	74.7	158	7527503 (2), 12543867 (2), 15696457 (2), 8712219 (2) (see all 99)
proteinuria	73.1	136	17255215 (4), 17978307 (3), 10412761 (3), 10802148 (3) (see all 90)
henoch-schonlein purpura	72.2	75	9568852 (5), 9557162 (3), 1928066 (3), 9002298 (3) (see all 40)
dermatitis herpetiformis	71.2	56	1972829 (5), 2182721 (3), 1885069 (3), 16631941 (2) (see all 27)

Human Genome Epidemiology (HuGE) Navigator: CD79A (5 documents)

Export disorders for CD79A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD79A gene, integrated from 9 sources (see all 2369):
(articles sorted by number of sources associating them with CD79A)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene. (PubMed id 1538135)^{1, 2, 3} Ha H.J.... Burrows P.D. (1992)
Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. (PubMed id 1534761)^{1, 2, 9} Mueller B.S.... Terhorst C. (1992)
Structure, chromosomal localization, and methylation pattern of the human mb-1 gene. (PubMed id 8207205)^{1, 2, 9} Ha H.... Burrows P.D. (1994)
Structure and expression of the mb-1 transcript in human lymphoid cells. (PubMed id 1395095)^{1, 2, 9} Leduc I.... Cogne M. (1992)
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor. (PubMed id 10748115)^{1, 2} Gaul B.S....Post C.B. (2000)
Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells. (PubMed id 7643857)^{1, 2} Hashimoto S.... Gregersen P.K. (1995)
Isolation and chemical characterization of the human B29 and mb-1 proteins of the B cell antigen receptor complex. (PubMed id 7514267)^{1, 2} Vasile S.... Seon B.K. (1994)
Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene. (PubMed id 7916003)^{1, 2} Hashimoto S.... Chiorazzi N. (1994)
Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes. (PubMed id 1729378)^{1, 2} Yu L.M. and Chang T.W. (1992)
Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex. (PubMed id 1639443)^{1, 2} Flaswinkel H. and Reth M. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 973	HGNC: 1698	AceView: CD79A	Ensembl:ENSG00000105369	euGenes: HUgn973
ECgene: CD79A	Kegg: 973	H-InvDB: CD79A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD79A	Pharmacogenomics, SNPs, Pathways
CD79Abase	http://bioinf.uta.fi/CD79Abase/

Intellectual Property for CD79A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD79A gene:
Search GeneIP for patents involving CD79A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CD79A Gene

CD79a molecule, immunoglobulin-associated alpha

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Spondylitis Ankylosing
Chronic tonsillitis
Nephritis
GLOMERULONEPHRITIS FOCAL
Arthritis Reactive
Alports Syndrome
Dental Caries
HYPER-IgM SYNDROME
IMMUNE DISORDER
Nephropathy Membranous
Dermatitis Herpetiformis
Dysgammaglobulinemia
Henoch-Schonlein Purpura
Pemphigoid Cicatricial
Colitis Ulcerative
allergy
Glomerulonephritis Membranoproliferative
Skin Diseases
Sjogrens Syndrome Primary
Antiphospholipid Syndrome
Nephrotic Syndrome
BILIARY CIRRHOSIS PRIMARY
IgA Deficiency
Colitis Amebic
Childhood celiac disease
Diabetes Mellitus Insulin-Dependent
Monoclonal gammopathy
Periodontal Diseases
Purpura
RENAL DISEASE
Pigeon Breeders Lung
IgG Deficiency
Nephropathy IGA
ICF SYNDROME
glomerulosclerosis
Inflammation
GLOMERULOSCLEROSIS, FOCAL SEGMENTAL
Proteinuria
immunodeficiency
MYELOMA
Hypergammaglobulinemia
Rheumatoid Arthritis
Chlamydial infection
Acute poststreptococcal glomerulonephritis
Allergy Milk
Celiac Disease
Autoimmunity
pemphigus
Tonsillitis
GLOMERULONEPHRITIS MESANGIAL PROLIFERATIVE
Hypogammaglobulinemia
Nephrotic Syndrome Minimal Change
Otitis Media
Autoimmune Diseases
Pemphigoid Bullous
HEMATURIA MICROSCOPIC
Vasculitis
atopy
Malabsorption
Chronic glomerulonephritis
Tetanus
Toxoplasmosis Congenital
Arteriolosclerosis
Common Variable Immunodeficiency
Sjogrens Syndrome
Membranous nephritis
Proliferative glomerulonephritis
Toxoplasmosis
Cryoglobulinemia
Respiratory Tract Infections
HIV Infections
Diphtheria
NASOPHARYNGEAL CARCINOMA
Membranoproliferative nephropathy
Sjogrens Syndrome Secondary
Epidermolysis Bullosa Acquisita
Pemphigus foliaceus
Giardiasis
Subcorneal Pustular Dermatosis
gammopathy
Vasculitis Leukocytoclastic
Atrophy
IGA DEFICIENCY SELECTIVE
Infection chronic
Lupus Nephritis
IGG SUBCLASS DEFICIENCY
Cholera
Glomerulonephritis
Plasmacytoma
Glomerulosclerosis Focal
Immune Complex Diseases
Renal Failure Chronic
Lupus Erythematosus Systemic

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CD79A Gene

CD79a molecule, immunoglobulin-associated alpha

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