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Aliases for CD79A Gene

Aliases for CD79A Gene

  • CD79a Molecule, Immunoglobulin-Associated Alpha 2 3
  • IGA 3 4 6
  • Membrane-Bound Immunoglobulin-Associated Protein 3 4
  • CD79A Antigen (Immunoglobulin-Associated Alpha) 2 3
  • Surface IgM-Associated Protein 3 4
  • MB-1 Membrane Glycoprotein 3 4
  • Ig-Alpha 3 4
  • B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain 3
  • CD79a Antigen 4
  • MB-1 3
  • MB1 4

External Ids for CD79A Gene

Previous HGNC Symbols for CD79A Gene

  • IGA

Previous GeneCards Identifiers for CD79A Gene

  • GC19P043020
  • GC19P042773
  • GC19P047057
  • GC19P047073
  • GC19P042381
  • GC19P038812

Summaries for CD79A Gene

Entrez Gene Summary for CD79A Gene

  • The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD79A Gene

CD79A (CD79a Molecule, Immunoglobulin-Associated Alpha) is a Protein Coding gene. Diseases associated with CD79A include agammaglobulinemia 3 and autosomal agammaglobulinemia. Among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for CD79A Gene

  • Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Gene Wiki entry for CD79A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD79A Gene

Genomics for CD79A Gene

Regulatory Elements for CD79A Gene

Transcription factor binding sites by QIAGEN in the CD79A gene promoter:

Genomic Location for CD79A Gene

Start:
41,877,120 bp from pter
End:
41,881,372 bp from pter
Size:
4,253 bases
Orientation:
Plus strand

Genomic View for CD79A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD79A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD79A Gene

Proteins for CD79A Gene

  • Protein details for CD79A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11912-CD79A_HUMAN
    Recommended name:
    B-cell antigen receptor complex-associated protein alpha chain
    Protein Accession:
    P11912
    Secondary Accessions:
    • A0N775
    • Q53FB8

    Protein attributes for CD79A Gene

    Size:
    226 amino acids
    Molecular mass:
    25038 Da
    Quaternary structure:
    • Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-210, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity (By similarity).

    Three dimensional structures from OCA and Proteopedia for CD79A Gene

    Alternative splice isoforms for CD79A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD79A Gene

Proteomics data for CD79A Gene at MOPED

Post-translational modifications for CD79A Gene

  • Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).
  • Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.
  • Glycosylation at Asn57, Asn63, Asn73, Asn88, Asn97, and Asn112
  • Modification sites at PhosphoSitePlus

Other Protein References for CD79A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD79A (Ig-alpha)

No data available for DME Specific Peptides for CD79A Gene

Domains for CD79A Gene

Gene Families for CD79A Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Suggested Antigen Peptide Sequences for CD79A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11912

UniProtKB/Swiss-Prot:

CD79A_HUMAN :
  • P11912
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 ITAM domain.
genes like me logo Genes that share domains with CD79A: view

Function for CD79A Gene

Molecular function for CD79A Gene

GENATLAS Biochemistry: Ig alpha component (47kDa),B cell Ag receptor,mouse mb-1 homolog (Ig-alpha/mb-1)
UniProtKB/Swiss-Prot Function: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Gene Ontology (GO) - Molecular Function for CD79A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CD79A: view
genes like me logo Genes that share phenotypes with CD79A: view

Animal Models for CD79A Gene

MGI Knock Outs for CD79A:

Animal Model Products

CRISPR Products

miRNA for CD79A Gene

miRTarBase miRNAs that target CD79A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD79A Gene

Localization for CD79A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD79A Gene

Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD79A Gene COMPARTMENTS Subcellular localization image for CD79A gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
vacuole 2
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD79A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005771 multivesicular body ISS --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane ISS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD79A: view

Pathways for CD79A Gene

genes like me logo Genes that share pathways with CD79A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CD79A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0030183 B cell differentiation ISS --
GO:0042100 B cell proliferation ISS --
GO:0042113 B cell activation ISS --
GO:0050853 B cell receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with CD79A: view

Compounds for CD79A Gene

(124) Novoseek inferred chemical compound relationships for CD79A Gene

Compound -log(P) Hits PubMed IDs
gliadin 86 145
gluten 76.3 66
unicap 50.8 4
cardiolipin 50.8 15
sulfolipid i 50.4 3
genes like me logo Genes that share compounds with CD79A: view

Transcripts for CD79A Gene

mRNA/cDNA for CD79A Gene

Unigene Clusters for CD79A Gene

CD79a molecule, immunoglobulin-associated alpha:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD79A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD79A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for CD79A Gene

GeneLoc Exon Structure for
CD79A
ECgene alternative splicing isoforms for
CD79A

Expression for CD79A Gene

mRNA expression in normal human tissues for CD79A Gene

mRNA differential expression in normal tissues according to GTEx for CD79A Gene

This gene is overexpressed in Spleen (12.4), Whole Blood (7.0), and Small Intestine - Terminal Ileum (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD79A Gene

SOURCE GeneReport for Unigene cluster for CD79A Gene Hs.631567

mRNA Expression by UniProt/SwissProt for CD79A Gene

P11912-CD79A_HUMAN
Tissue specificity: B-cells
genes like me logo Genes that share expressions with CD79A: view

In Situ Assay Products

Orthologs for CD79A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD79A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD79A 35
  • 99.41 (n)
  • 99.12 (a)
CD79A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD79A 35
  • 79.37 (n)
  • 71.3 (a)
CD79A 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD79A 35
  • 81.86 (n)
  • 76.11 (a)
CD79A 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd79a 35
  • 74.55 (n)
  • 70.91 (a)
Cd79a 16
Cd79a 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100913063 35
  • 75.12 (n)
  • 71.29 (a)
lizard
(Anolis carolinensis)
Reptilia CD79A 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485353 35
  • 52.75 (n)
  • 45.41 (a)
zebrafish
(Danio rerio)
Actinopterygii cd79a 35
  • 48.94 (n)
  • 37.56 (a)
cd79a 36
  • 31 (a)
OneToOne
Species with no ortholog for CD79A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD79A Gene

ENSEMBL:
Gene Tree for CD79A (if available)
TreeFam:
Gene Tree for CD79A (if available)

Paralogs for CD79A Gene

No data available for Paralogs for CD79A Gene

Variants for CD79A Gene

Sequence variations from dbSNP and Humsavar for CD79A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1428922 -- 41,875,710(+) GAGAC(A/G)GCCTT upstream-variant-2KB
rs8101483 -- 41,880,664(+) CACCC(C/T)TACAG intron-variant
rs10405900 -- 41,875,310(+) CAGGC(A/G)TGGTG upstream-variant-2KB
rs10415452 -- 41,878,675(+) GGGGG(A/G)CAAGA intron-variant
rs10415627 -- 41,878,659(+) AAGTG(C/G)GTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD79A Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
dgv3882n71 CNV Loss 21882294
dgv3883n71 CNV Loss 21882294
nsv520239 CNV Loss 19592680

Relevant External Links for CD79A Gene

HapMap Linkage Disequilibrium report
CD79A
Human Gene Mutation Database (HGMD)
CD79A
Locus Specific Mutation Databases (LSDB)
CD79A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD79A Gene

Disorders for CD79A Gene

(1) OMIM Diseases for CD79A Gene (112205)

UniProtKB/Swiss-Prot

CD79A_HUMAN
  • Agammaglobulinemia 3, autosomal recessive (AGM3) [MIM:613501]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269 PubMed:10525050, ECO:0000269 PubMed:11920841}. Note=The disease is caused by mutations affecting the gene represented in this entry. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.

(98) University of Copenhagen DISEASES for CD79A Gene

(93) Novoseek inferred disease relationships for CD79A Gene

Disease -log(P) Hits PubMed IDs
nephropathy iga 95.2 646
iga deficiency 91.7 287
iga deficiency selective 83.6 102
celiac disease 82.8 109
hyper-igm syndrome 78.2 18

Relevant External Links for CD79A

Genetic Association Database (GAD)
CD79A
Human Genome Epidemiology (HuGE) Navigator
CD79A
genes like me logo Genes that share disorders with CD79A: view

Publications for CD79A Gene

  1. Structure and expression of the mb-1 transcript in human lymphoid cells. (PMID: 1395095) Leduc I. … Cogne M. (Clin. Exp. Immunol. 1992) 3 4 23
  2. Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene. (PMID: 1538135) Ha H.J. … Burrows P.D. (J. Immunol. 1992) 2 3 4
  3. Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. (PMID: 1534761) Mueller B.S. … Terhorst C. (Eur. J. Immunol. 1992) 3 4
  4. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PMID: 19573080) Liang X.S. … Goldin L.R. (Br. J. Haematol. 2009) 3 48
  5. Structure, chromosomal localization, and methylation pattern of the human mb-1 gene. (PMID: 8207205) Ha H. … Burrows P.D. (J. Immunol. 1994) 3 4

Products for CD79A Gene

Sources for CD79A Gene

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