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CD79A Gene(Protein Coding)

CD79a Molecule

GCID:
GC19P041877
GIFtS:
66
Genes Participants
UDN Logo

Aliases for CD79A Gene

Aliases for CD79A Gene

  • CD79a Molecule 2 3 5
  • Membrane-Bound Immunoglobulin-Associated Protein 3 4
  • CD79A Antigen (Immunoglobulin-Associated Alpha) 2 3
  • CD79a Molecule, Immunoglobulin-Associated Alpha 2 3
  • Surface IgM-Associated Protein 3 4
  • MB-1 Membrane Glycoprotein 3 4
  • Ig-Alpha 3 4
  • IGA 3 4
  • B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain 3
  • CD79a Antigen 4
  • MB-1 3
  • MB1 4

External Ids for CD79A Gene

Previous HGNC Symbols for CD79A Gene

  • IGA

Previous GeneCards Identifiers for CD79A Gene

  • GC19P043020
  • GC19P042773
  • GC19P047057
  • GC19P047073
  • GC19P042381
  • GC19P038812

Summaries for CD79A Gene

Entrez Gene Summary for CD79A Gene

  • The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD79A Gene

CD79A (CD79a Molecule) is a Protein Coding gene. Diseases associated with CD79A include Agammaglobulinemia 3 and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Phospholipase-C Pathway and Development Angiotensin activation of ERK. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for CD79A Gene

  • Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Gene Wiki entry for CD79A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD79A Gene

Genomics for CD79A Gene

Products:

  1. Regulatory Element

Regulatory Elements for CD79A Gene

Enhancers for CD79A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G041867 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -3.2 -3206 12.3 HDGF PKNOX1 AGO1 WRNIP1 SIN3A ZNF2 ZNF143 PAF1 ZNF263 SP3 ARHGEF1 CD79A RABAC1 POU2F2 DEDD2 CEACAM4 CEACAM21 CEACAM3 ZNF574 MIR6797
GH19G041937 1.6 FANTOM5 Ensembl ENCODE 13.6 +62.6 62600 4.3 HDGF PKNOX1 FOXA2 CREB3L1 ZNF133 ARID4B DMAP1 ZNF48 YY1 GLIS2 RABAC1 CD79A ARHGEF1 POU2F2 LOC100505585
GH19G041957 1.4 ENCODE dbSUPER 12.2 +81.5 81515 2.9 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF526 RABAC1 RPS19 CCDC97 MEGF8 CD79A ATP1A3 ZNF574 ERF TMEM145
GH19G041951 1.2 Ensembl ENCODE 12.2 +74.7 74681 0.4 HDGF FOXA2 PKNOX1 ZNF133 SIN3A ZNF2 GLIS2 ZNF143 FOS ZNF263 ZNF526 CD79A RPS19 ATP1A3 RABAC1 LOC100505585
GH19G042301 1.1 ENCODE 4.9 +425.6 425573 2.3 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 KLF13 ZNF263 SP3 SP5 ZNF526 CCDC97 ERF ZNF574 RPS19 MEGF8 CD79A PRR19 PAFAH1B3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD79A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CD79A gene promoter:

Genomic Location for CD79A Gene

Chromosome:
19
Start:
41,877,120 bp from pter
End:
41,881,372 bp from pter
Size:
4,253 bases
Orientation:
Plus strand

Genomic View for CD79A Gene

Genes around CD79A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD79A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD79A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD79A Gene

Proteins for CD79A Gene

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  • Protein details for CD79A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11912-CD79A_HUMAN
    Recommended name:
    B-cell antigen receptor complex-associated protein alpha chain
    Protein Accession:
    P11912
    Secondary Accessions:
    • A0N775
    • Q53FB8

    Protein attributes for CD79A Gene

    Size:
    226 amino acids
    Molecular mass:
    25038 Da
    Quaternary structure:
    • Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-210, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity (By similarity).

    Three dimensional structures from OCA and Proteopedia for CD79A Gene

    Alternative splice isoforms for CD79A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD79A Gene

Protein Expression for CD79A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD79A Gene

  • Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B-cell differentiation (By similarity).
  • Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylated by LYN. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.
  • Glycosylation at Asn57, posLast=6363, Asn73, Asn88, posLast=9797, and posLast=112112
  • Modification sites at PhosphoSitePlus

Other Protein References for CD79A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD79A Gene

Domains & Families for CD79A Gene

Gene Families for CD79A Gene

HGNC:

Protein Domains for CD79A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD79A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD79A: view

No data available for UniProtKB/Swiss-Prot for CD79A Gene

Function for CD79A Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  7. Flow Cytometry

Molecular function for CD79A Gene

GENATLAS Biochemistry:
Ig alpha component (47kDa),B cell Ag receptor,mouse mb-1 homolog (Ig-alpha/mb-1)
UniProtKB/Swiss-Prot Function:
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Gene Ontology (GO) - Molecular Function for CD79A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IMP 14967045
genes like me logo Genes that share ontologies with CD79A: view
genes like me logo Genes that share phenotypes with CD79A: view

Human Phenotype Ontology for CD79A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD79A Gene

MGI Knock Outs for CD79A:

Animal Model Products

CRISPR Products

miRNA for CD79A Gene

miRTarBase miRNAs that target CD79A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD79A Gene

Localization for CD79A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD79A Gene

Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD79A gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CD79A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005771 multivesicular body ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0009897 external side of plasma membrane ISS,IBA --
genes like me logo Genes that share ontologies with CD79A: view

Pathways & Interactions for CD79A Gene

genes like me logo Genes that share pathways with CD79A: view

SIGNOR curated interactions for CD79A Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CD79A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0030183 B cell differentiation ISS,IBA --
GO:0042100 B cell proliferation ISS --
genes like me logo Genes that share ontologies with CD79A: view

Drugs & Compounds for CD79A Gene

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  1. Drug

(71) Drugs for CD79A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(53) Additional Compounds for CD79A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD79A: view

Transcripts for CD79A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CD79A Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(261) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD79A Gene

CD79a molecule, immunoglobulin-associated alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD79A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for CD79A Gene

GeneLoc Exon Structure for
CD79A
ECgene alternative splicing isoforms for
CD79A

Expression for CD79A Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD79A Gene

mRNA expression in normal human tissues for CD79A Gene
mRNA expression by BioGPS for CD79A GenemRNA expression by GTEx for CD79A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD79A Gene

This gene is overexpressed in Spleen (x12.4), Whole Blood (x7.0), and Small Intestine - Terminal Ileum (x5.2).

Protein differential expression in normal tissues from HIPED for CD79A Gene

This gene is overexpressed in Blymphocyte (48.1) and Lymph node (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD79A Gene



Protein tissue co-expression partners for CD79A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD79A Gene:

CD79A

SOURCE GeneReport for Unigene cluster for CD79A Gene:

Hs.631567

mRNA Expression by UniProt/SwissProt for CD79A Gene:

P11912-CD79A_HUMAN
Tissue specificity: B-cells.

Evidence on tissue expression from TISSUES for CD79A Gene

  • Intestine(4.8)
  • Blood(4)
  • Lymph node(4)
  • Spleen(3.9)
  • Bone marrow(3.7)
  • Saliva(3.6)
  • Stomach(3.2)
  • Kidney(3.1)
  • Lung(3.1)
  • Skin(3)
  • Urine(2.6)
  • Liver(2.5)
  • Nervous system(2.3)
  • Heart(2.1)
  • Thyroid gland(2.1)
  • Gall bladder(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD79A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • meninges
  • middle ear
  • mouth
  • neck
  • outer ear
  • sinus
  • skull
Thorax:
  • bronchus
  • chest wall
  • clavicle
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • biliary tract
  • gallbladder
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
Pelvis:
  • pelvis
  • rectum
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with CD79A: view

Primer Products

Orthologs for CD79A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD79A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CD79A 34 35
  • 99.41 (n)
dog
(Canis familiaris)
 Mammalia CD79A 34 35
  • 81.86 (n)
cow
(Bos Taurus)
 Mammalia CD79A 34 35
  • 79.37 (n)
rat
(Rattus norvegicus)
 Mammalia LOC100913063 34
  • 75.12 (n)
mouse
(Mus musculus)
 Mammalia Cd79a 34 16 35
  • 74.55 (n)
lizard
(Anolis carolinensis)
 Reptilia CD79A 35
  • 41 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100485353 34
  • 52.75 (n)
zebrafish
(Danio rerio)
 Actinopterygii cd79a 34 35
  • 48.94 (n)
Species where no ortholog for CD79A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD79A Gene

ENSEMBL:
Gene Tree for CD79A (if available)
TreeFam:
Gene Tree for CD79A (if available)

Paralogs for CD79A Gene

No data available for Paralogs for CD79A Gene

Variants for CD79A Gene

Sequence variations from dbSNP and Humsavar for CD79A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs371184689 Uncertain significance 41,877,332(+) TCCAA(A/G)CTCTG reference, missense
rs143511203 untested 41,879,230(+) GTGCC(A/G)GGTCC intron-variant, reference, missense
rs144367487 untested 41,879,281(+) CCTCC(A/G)CGTGC intron-variant, reference, missense
rs148797987 untested 41,879,574(+) GGGCA(A/C/T)CAAGA reference, missense
rs532288711 untested 41,880,892(+) CTCCA(C/T)GTATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD79A Gene

Variant ID Type Subtype PubMed ID
nsv520239 CNV loss 19592680
nsv522854 CNV gain 19592680
nsv953579 CNV deletion 24416366

Variation tolerance for CD79A Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD79A Gene

Human Gene Mutation Database (HGMD)
CD79A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD79A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD79A Gene

Disorders for CD79A Gene

MalaCards: The human disease database

(304) MalaCards diseases for CD79A Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
agammaglobulinemia 3
  • agammaglobulinemia 3, autosomal recessive
agammaglobulinemia, non-bruton type
  • autosomal agammaglobulinemia
iga glomerulonephritis
  • berger's iga or igg nephropathy
tonsillitis
  • chronic tonsillitis
dermatitis herpetiformis
  • dermatitis herpetiformis [dup]
- elite association - COSMIC cancer census association via MalaCards
Search CD79A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD79A_HUMAN
  • Agammaglobulinemia 3, autosomal recessive (AGM3) [MIM:613501]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269 PubMed:10525050, ECO:0000269 PubMed:11920841}. Note=The disease is caused by mutations affecting the gene represented in this entry. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.

Relevant External Links for CD79A

Genetic Association Database (GAD)
CD79A
Human Genome Epidemiology (HuGE) Navigator
CD79A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD79A
genes like me logo Genes that share disorders with CD79A: view

No data available for Genatlas for CD79A Gene

Publications for CD79A Gene

  1. Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene. (PMID: 1538135) Ha H.J. … Burrows P.D. (J. Immunol. 1992) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PMID: 19573080) Liang X.S. … Goldin L.R. (Br. J. Haematol. 2009) 3 46 64
  4. Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific B29 (Ig beta) and mb-1 (Ig alpha) promoters. (PMID: 11907094) Malone C.S. … Wall R. (J. Immunol. 2002) 3 22 64
  5. Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor. (PMID: 10748115) Gaul B.S. … Post C.B. (J. Biol. Chem. 2000) 3 4 64

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