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Aliases for CD74 Gene

Aliases for CD74 Gene

  • CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain 2 3
  • DHLAG 3 4 6
  • CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated) 2 3
  • HLA-DR Antigens-Associated Invariant Chain 3 4
  • Gamma Chain Of Class II Antigens 2 3
  • Ia-Associated Invariant Chain 2 3
  • MHC HLA-DR Gamma Chain 2 3
  • HLA-DR-Gamma 2 3
  • P33 3 4
  • II 3 4
  • HLA Class II Histocompatibility Antigen Gamma Chain 3
  • Ia Antigen-Associated Invariant Chain 4
  • CD74 Antigen 4
  • Ia-GAMMA 3
  • HLADG 3

External Ids for CD74 Gene

Previous Symbols for CD74 Gene

  • DHLAG

Summaries for CD74 Gene

Entrez Gene Summary for CD74 Gene

  • The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD74 Gene

CD74 (CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain) is a Protein Coding gene. Diseases associated with CD74 include undifferentiated pleomorphic sarcoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and MHC class II antigen presentation. GO annotations related to this gene include identical protein binding and cytokine receptor activity.

UniProtKB/Swiss-Prot for CD74 Gene

  • Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF

Gene Wiki entry for CD74 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD74 Gene

Genomics for CD74 Gene

Genomic Location for CD74 Gene

Start:
150,401,637 bp from pter
End:
150,412,980 bp from pter
Size:
11,344 bases
Orientation:
Minus strand

Genomic View for CD74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD74 Gene

Regulatory Elements for CD74 Gene

Proteins for CD74 Gene

  • Protein details for CD74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04233-HG2A_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen gamma chain
    Protein Accession:
    P04233
    Secondary Accessions:
    • A8K7R1
    • B4DNE8
    • D3DQG3
    • D3DQG4
    • Q14597
    • Q29832
    • Q5U0J8
    • Q8SNA0
    • Q8WLP6

    Protein attributes for CD74 Gene

    Size:
    296 amino acids
    Molecular mass:
    33516 Da
    Quaternary structure:
    • Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.
    SequenceCaution:
    • Sequence=AAA36304.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD74 Gene

    Alternative splice isoforms for CD74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD74 Gene

Proteomics data for CD74 Gene at MOPED

Post-translational modifications for CD74 Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys159 and Lys170
  • Glycosylation at Asn130, Asn136, Ser197, Thr203, Asn256, and Ser281

Other Protein References for CD74 Gene

No data available for DME Specific Peptides for CD74 Gene

Domains for CD74 Gene

Gene Families for CD74 Gene

HGNC:
  • CD :CD molecules

UniProtKB/Swiss-Prot:

HG2A_HUMAN
Domain:
  • Contains 1 thyroglobulin type-1 domain.:
    • P04233
genes like me logo Genes that share domains with CD74: view

Function for CD74 Gene

Molecular function for CD74 Gene

GENATLAS Biochemistry: cell differentiation antigen CD74,MHC class II associated invariant chain,identified by monoclonal antibodies LN2,BU-43,BU-45,chain Ii,31kDa
UniProtKB/Swiss-Prot Function: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF

Gene Ontology (GO) - Molecular Function for CD74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IPI 19849849
GO:0004896 cytokine receptor activity IDA 17045821
GO:0005515 protein binding IPI 19665027
GO:0019955 cytokine binding IPI 12782713
GO:0023026 MHC class II protein complex binding IDA 1448172
genes like me logo Genes that share ontologies with CD74: view
genes like me logo Genes that share phenotypes with CD74: view

Animal Models for CD74 Gene

MGI Knock Outs for CD74:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD74 Gene

Localization for CD74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD74 Gene

Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD74 Gene COMPARTMENTS Subcellular localization image for CD74 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
golgi apparatus 4
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular TAS 12782713
GO:0005764 lysosome --
GO:0005765 lysosomal membrane TAS --
GO:0005770 late endosome --
genes like me logo Genes that share ontologies with CD74: view

Pathways for CD74 Gene

genes like me logo Genes that share pathways with CD74: view

Pathways by source for CD74 Gene

Gene Ontology (GO) - Biological Process for CD74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0001516 prostaglandin biosynthetic process IDA 12782713
GO:0001961 positive regulation of cytokine-mediated signaling pathway IMP 12782713
GO:0002606 positive regulation of dendritic cell antigen processing and presentation IEA --
GO:0002792 negative regulation of peptide secretion IDA 19849849
genes like me logo Genes that share ontologies with CD74: view

Transcripts for CD74 Gene

Unigene Clusters for CD74 Gene

CD74 molecule, major histocompatibility complex, class II invariant chain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD74 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - - -
SP14: - - - - - - - - - - - -

Relevant External Links for CD74 Gene

GeneLoc Exon Structure for
CD74
ECgene alternative splicing isoforms for
CD74

Expression for CD74 Gene

mRNA expression in normal human tissues for CD74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD74 Gene

This gene is overexpressed in Spleen (5.3) and Whole Blood (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD74 Gene

SOURCE GeneReport for Unigene cluster for CD74 Gene Hs.436568

genes like me logo Genes that share expressions with CD74: view

Orthologs for CD74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD74 36
  • 99.14 (n)
  • 99.57 (a)
CD74 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD74 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD74 36
  • 88.36 (n)
  • 82.72 (a)
CD74 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd74 36
  • 82.13 (n)
  • 77.34 (a)
Cd74 16
Cd74 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD74 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD74 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd74 36
  • 81.85 (n)
  • 75.92 (a)
chicken
(Gallus gallus)
Aves CD74 36
  • 60.58 (n)
  • 47.91 (a)
II 37
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD74 37
  • 42 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10251 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cd74 36
  • 50.2 (n)
  • 35.57 (a)
zebrafish
(Danio rerio)
Actinopterygii cd74a 37
  • 30 (a)
OneToOne
Species with no ortholog for CD74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD74 Gene

ENSEMBL:
Gene Tree for CD74 (if available)
TreeFam:
Gene Tree for CD74 (if available)

Paralogs for CD74 Gene

Selected SIMAP similar genes for CD74 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD74: view

No data available for Paralogs for CD74 Gene

Variants for CD74 Gene

Sequence variations from dbSNP and Humsavar for CD74 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs762800 -- 150,404,393(-) GTACA(C/G)GACAG intron-variant
rs1004978 -- 150,407,023(-) TCATC(A/T)GGGTC intron-variant
rs1051661 -- 150,402,168(-) GCCCC(A/C)AGCCC utr-variant-3-prime, downstream-variant-500B
rs1051800 -- 150,402,162(-) AGCCC(C/T)TCCCC utr-variant-3-prime, downstream-variant-500B
rs1051813 -- 150,402,161(-) GCCCC(C/T)CCCCC utr-variant-3-prime, downstream-variant-500B

Relevant External Links for CD74 Gene

HapMap Linkage Disequilibrium report
CD74

No data available for Structural Variations from Database of Genomic Variants (DGV) for CD74 Gene

Disorders for CD74 Gene

UniProtKB/Swiss-Prot

HG2A_HUMAN
  • Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein. {ECO:0000269 PubMed:12661006}.

(1) University of Copenhagen DISEASES for CD74 Gene

Relevant External Links for CD74

Genetic Association Database (GAD)
CD74
Human Genome Epidemiology (HuGE) Navigator
CD74
genes like me logo Genes that share disorders with CD74: view

Publications for CD74 Gene

  1. Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens. (PMID: 3001652) Kudo J. … Saunders G.F. (Nucleic Acids Res. 1985) 2 3 4
  2. cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. (PMID: 6324166) Claesson L. … Peterson P.A. (Proc. Natl. Acad. Sci. U.S.A. 1983) 2 3 4
  3. The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity. (PMID: 6586420) Strubin M. … Long E.O. (EMBO J. 1984) 3 4
  4. Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes. (PMID: 3459184) O'Sullivan D.M. … Quaranta V. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3 4
  5. Tumor HLA-DR expression linked to early intrahepatic recurrence of hepatocellular carcinoma. (PMID: 15688398) Matoba K. … Oka M. (Int. J. Cancer 2005) 3 23

Products for CD74 Gene

Sources for CD74 Gene

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