Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD74 Gene

Aliases for CD74 Gene

  • CD74 Molecule 2 3
  • CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain 2 3 5
  • CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated) 2 3
  • HLA-DR Antigens-Associated Invariant Chain 3 4
  • Gamma Chain Of Class II Antigens 2 3
  • Ia-Associated Invariant Chain 2 3
  • MHC HLA-DR Gamma Chain 2 3
  • HLA-DR-Gamma 2 3
  • DHLAG 3 4
  • P33 3 4
  • II 3 4
  • Ia Antigen-Associated Invariant Chain 4
  • CD74 Antigen 4
  • Ia-GAMMA 3
  • HLADG 3

External Ids for CD74 Gene

Previous HGNC Symbols for CD74 Gene

  • DHLAG

Previous GeneCards Identifiers for CD74 Gene

  • GC05M149850
  • GC05M149764
  • GC05M149809
  • GC05M149753
  • GC05M144928

Summaries for CD74 Gene

Entrez Gene Summary for CD74 Gene

  • The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD74 Gene

CD74 (CD74 Molecule) is a Protein Coding gene. Diseases associated with CD74 include undifferentiated pleomorphic sarcoma and mantle cell lymphoma. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include identical protein binding and beta-amyloid binding.

UniProtKB/Swiss-Prot for CD74 Gene

  • Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Gene Wiki entry for CD74 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD74 Gene

Genomics for CD74 Gene

Regulatory Elements for CD74 Gene

Promoters for CD74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD74 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD74 Gene

Chromosome:
5
Start:
150,401,637 bp from pter
End:
150,412,936 bp from pter
Size:
11,300 bases
Orientation:
Minus strand

Genomic View for CD74 Gene

Genes around CD74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD74 Gene

Proteins for CD74 Gene

  • Protein details for CD74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04233-HG2A_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen gamma chain
    Protein Accession:
    P04233
    Secondary Accessions:
    • A8K7R1
    • B4DNE8
    • D3DQG3
    • D3DQG4
    • Q14597
    • Q29832
    • Q5U0J8
    • Q8SNA0
    • Q8WLP6

    Protein attributes for CD74 Gene

    Size:
    296 amino acids
    Molecular mass:
    33516 Da
    Quaternary structure:
    • Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules.
    SequenceCaution:
    • Sequence=AAA36304.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD74 Gene

    Alternative splice isoforms for CD74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD74 Gene

Proteomics data for CD74 Gene at MOPED

Post-translational modifications for CD74 Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Ubiquitination at Lys 159 and Lys 170
  • Glycosylation at Asn 130, Asn 136, Thr 203, Asn 256, and Ser 281
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CD74 Gene

Domains & Families for CD74 Gene

Gene Families for CD74 Gene

Suggested Antigen Peptide Sequences for CD74 Gene

Graphical View of Domain Structure for InterPro Entry

P04233

UniProtKB/Swiss-Prot:

HG2A_HUMAN :
  • Contains 1 thyroglobulin type-1 domain.
Domain:
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with CD74: view

Function for CD74 Gene

Molecular function for CD74 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD74,MHC class II associated invariant chain,identified by monoclonal antibodies LN2,BU-43,BU-45,chain Ii,31kDa
UniProtKB/Swiss-Prot Function:
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Gene Ontology (GO) - Molecular Function for CD74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042658 MHC class II protein binding, via antigen binding groove IDA 7477400
genes like me logo Genes that share ontologies with CD74: view
genes like me logo Genes that share phenotypes with CD74: view

Animal Models for CD74 Gene

MGI Knock Outs for CD74:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD74 Gene

Localization for CD74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD74 Gene

Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD74 Gene COMPARTMENTS Subcellular localization image for CD74 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
extracellular 5
golgi apparatus 5
lysosome 5
plasma membrane 5
vacuole 5
cytoskeleton 3
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA,TAS 12782713
GO:0005764 lysosome IEA --
GO:0005770 late endosome IEA --
GO:0005771 multivesicular body IEA --
GO:0005773 vacuole IDA 19849849
genes like me logo Genes that share ontologies with CD74: view

Pathways & Interactions for CD74 Gene

genes like me logo Genes that share pathways with CD74: view

SIGNOR curated interactions for CD74 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CD74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001961 positive regulation of cytokine-mediated signaling pathway IEA,IMP 12782713
GO:0002792 negative regulation of peptide secretion IDA 19849849
GO:0002830 positive regulation of type 2 immune response IEA --
GO:0006461 protein complex assembly IEA,ISS --
GO:0006886 intracellular protein transport IEA,ISS --
genes like me logo Genes that share ontologies with CD74: view

Drugs & Compounds for CD74 Gene

(1) Drugs for CD74 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
milatuzumab Pharma antibody Therapeutic Antibodies 0
genes like me logo Genes that share compounds with CD74: view

Transcripts for CD74 Gene

Unigene Clusters for CD74 Gene

CD74 molecule, major histocompatibility complex, class II invariant chain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD74 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - - -
SP14: - - - - - - - - - - - -

Relevant External Links for CD74 Gene

GeneLoc Exon Structure for
CD74
ECgene alternative splicing isoforms for
CD74

Expression for CD74 Gene

mRNA expression in normal human tissues for CD74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD74 Gene

This gene is overexpressed in Spleen (x5.3) and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for CD74 Gene

This gene is overexpressed in Lymph node (16.0), Blymphocyte (12.6), and Nasal epithelium (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD74 Gene



SOURCE GeneReport for Unigene cluster for CD74 Gene Hs.436568

genes like me logo Genes that share expression patterns with CD74: view

Protein tissue co-expression partners for CD74 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CD74 Gene

Orthologs for CD74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD74 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CD74 35
  • 88.36 (n)
  • 82.72 (a)
CD74 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd74 35
  • 82.13 (n)
  • 77.34 (a)
Cd74 16
Cd74 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD74 35
  • 99.14 (n)
  • 99.57 (a)
CD74 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd74 35
  • 81.85 (n)
  • 75.92 (a)
cow
(Bos Taurus)
Mammalia CD74 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD74 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD74 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD74 35
  • 60.58 (n)
  • 47.91 (a)
II 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD74 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd74 35
  • 50.2 (n)
  • 35.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10251 35
zebrafish
(Danio rerio)
Actinopterygii cd74a 36
  • 30 (a)
OneToOne
Species with no ortholog for CD74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD74 Gene

ENSEMBL:
Gene Tree for CD74 (if available)
TreeFam:
Gene Tree for CD74 (if available)

Paralogs for CD74 Gene

(4) SIMAP similar genes for CD74 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD74: view

No data available for Paralogs for CD74 Gene

Variants for CD74 Gene

Sequence variations from dbSNP and Humsavar for CD74 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1051661 -- 150,402,168(-) GCCCC(A/C)AGCCC utr-variant-3-prime
rs1051800 -- 150,402,162(-) AGCCC(C/T)TCCCC utr-variant-3-prime
rs1051813 -- 150,402,161(-) GCCCC(C/T)CCCCC utr-variant-3-prime
rs1052718 -- 150,402,141(-) CCTGT(A/G)CCTCA utr-variant-3-prime
rs1056400 -- 150,402,064(-) AGATA(A/G)CAATG utr-variant-3-prime

Variation tolerance for CD74 Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD74 Gene

HapMap Linkage Disequilibrium report
CD74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD74 Gene

Disorders for CD74 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CD74 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
undifferentiated pleomorphic sarcoma
  • malignant fibrous histiocytoma
mantle cell lymphoma
  • lymphocytic choriomeningitis
adenosquamous cell lung carcinoma
  • adenosquamous lung carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CD74 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HG2A_HUMAN
  • Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein. {ECO:0000269 PubMed:12661006}.

Relevant External Links for CD74

Genetic Association Database (GAD)
CD74
Human Genome Epidemiology (HuGE) Navigator
CD74
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD74
genes like me logo Genes that share disorders with CD74: view

No data available for Genatlas for CD74 Gene

Publications for CD74 Gene

  1. Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens. (PMID: 3001652) Kudo J. … Saunders G.F. (Nucleic Acids Res. 1985) 2 3 4 67
  2. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (PMID: 17045821) Shi X. … Bucala R. (Immunity 2006) 3 23
  3. Tumor HLA-DR expression linked to early intrahepatic recurrence of hepatocellular carcinoma. (PMID: 15688398) Matoba K. … Oka M. (Int. J. Cancer 2005) 3 23
  4. cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. (PMID: 6324166) Claesson L. … Peterson P.A. (Proc. Natl. Acad. Sci. U.S.A. 1983) 2 3
  5. A conserved WW domain-like motif regulates invariant chain-dependent cell-surface transport of the NKG2D ligand ULBP2. (PMID: 25983110) Uhlenbrock F. … Skov S. (Mol. Immunol. 2015) 3

Products for CD74 Gene

Sources for CD74 Gene

Back to Top

Content