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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD74 Gene

protein-coding   GIFtS: 66
GCID: GC05M149753

CD74 Molecule, Major Histocompatibility Complex, Class II...

(Previous names: CD74 antigen (invariant polypeptide of major histocompatibility...)
(Previous symbol: DHLAG)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD74 Molecule, Major Histocompatibility Complex, Class II Invariant
Chain1 2
     p332 3
DHLAG1 2 3 5     HLADG2
CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex,
Class II Antigen-Associated)1 2
     II2
HLA-DR-gamma1 2     Ia-GAMMA2
Gamma Chain Of Class II Antigens1 2     HLA Class II Histocompatibility Antigen Gamma Chain2
Ia-Associated Invariant Chain1 2     Ii3
MHC HLA-DR Gamma Chain1 2     CD74 Antigen3
HLA-DR Antigens-Associated Invariant Chain2 3     Ia Antigen-Associated Invariant Chain3

External Ids:    HGNC: 16971   Entrez Gene: 9722   Ensembl: ENSG000000195827   OMIM: 1427905   UniProtKB: P042333   

Export aliases for CD74 gene to outside databases

Previous GC identifers: GC05M149850 GC05M150378 GC05M149764 GC05M149809 GC05M144928


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD74 Gene:
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an
important chaperone that regulates antigen presentation for immune response. It also serves as cell surface
receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein,
initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein
(APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants
encoding different isoforms have been identified. (provided by RefSeq, Aug 2011)

GeneCards Summary for CD74 Gene: 
CD74 (CD74 molecule, major histocompatibility complex, class II invariant chain) is a protein-coding gene. Diseases associated with CD74 include thymic epithelial neoplasm, and gastroduodenitis, and among its related super-pathways are Immune System and Immune response Antigen presentation by MHC class II. GO annotations related to this gene include cytokine receptor activity and identical protein binding.

UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233
Function: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta
heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic
reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC
class II takes place. Serves as cell surface receptor for the cytokine MIF

Gene Wiki entry for CD74 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD74 gene promoter:
         Pax-6   AP-2gamma   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CD74 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD74

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

CD74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD74 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M149753:  view genomic region     (about GC identifiers)

Start:
149,781,200 bp from pter      End:
149,792,492 bp from pter
Size:
11,293 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen gamma chain  
Size: 296 amino acids; 33516 Da
Subunit: Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class
II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74
component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small
fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule
(alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to
release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules
Subcellular location: Cell membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum
membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of
intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane
Sequence caution: Sequence=AAA36304.1; Type=Erroneous initiation;
6/12 PDB 3D structures from and Proteopedia for CD74 (see all 12):
1A6A (3D)        1ICF (3D)        1IIE (3D)        1L3H (3D)        1MUJ (3D)        3PDO (3D)    
Secondary accessions: A8K7R1 B4DNE8 D3DQG3 D3DQG4 Q14597 Q29832 Q5U0J8 Q8SNA0 Q8WLP6
Alternative splicing: 3 isoforms:  P04233-1   P04233-2   P04233-3   

Explore the universe of human proteins at neXtProt for CD74: NX_P04233

Explore proteomics data for CD74 at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04233

  • CD74 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD74 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001020329.1  NP_001020330.1  NP_004346.1  

    ENSEMBL proteins: 
     ENSP00000367026   ENSP00000230685   ENSP00000430614   ENSP00000429024   ENSP00000009530  
     ENSP00000430654   ENSP00000429641   ENSP00000429478  
    Reactome Protein details: P04233
    Human Recombinant Protein Products for CD74: 
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    R&D Systems Recombinant & Natural Proteins for CD74
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD74
    OriGene Protein Over-expression Lysate for CD74
    OriGene MassSpec for CD74 
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    GenScript Custom Purified and Recombinant Proteins Services for CD74
    Novus Biologicals CD74 Proteins
    Novus Biologicals CD74 Lysates
    Sino Biological Recombinant Protein for CD74
    Sino Biological Cell Lysate for CD74 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/24 cellular component terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005622intracellular TAS12782713
    GO:0005764lysosome ----
    GO:0005765lysosomal membrane TAS--
    GO:0005770late endosome ----

    CD74 for ontologies           About GeneDecksing



    CD74 Antibody Products: 
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    Novus Biologicals CD74 Antibodies
    Abcam antibodies for CD74
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    ThermoFisher Antibody for CD74
    LSBio Antibodies in human, mouse, rat for CD74 

    Assay Products for CD74: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    4 InterPro protein domains:
     IPR000716 Thyroglobulin_1
     IPR022339 MHC_II-assoc_invar_chain
     IPR015386 MHC_II-assoc_invar/CLIP_MHC-bd
     IPR011988 MHC_II-assoc_invariant_trimer

    Graphical View of Domain Structure for InterPro Entry P04233

    ProtoNet protein and cluster: P04233

    1 Blocks protein domain: IPB000716 Thyroglobulin type-1

    UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233
    Similarity: Contains 1 thyroglobulin type-1 domain


    CD74 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HG2A_HUMAN, P04233
    Function: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta
    heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic
    reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC
    class II takes place. Serves as cell surface receptor for the cytokine MIF

         Genatlas biochemistry entry for CD74:
    cell differentiation antigen CD74,MHC class II associated invariant chain,identified by monoclonal antibodies
    LN2,BU-43,BU-45,chain Ii,31kDa

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IPI19849849
    GO:0004896cytokine receptor activity IDA17045821
    GO:0005515protein binding IPI19665027
    GO:0019955cytokine binding IPI12782713
    GO:0035718macrophage migration inhibitory factor binding IPI17045821
         
    CD74 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD74:
     Decreased TP53 protein express  Decreased viability of wild-ty 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cd74):
     cellular  growth/size  hematopoietic system  immune system  mortality/aging 

    CD74 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD74: Cd74tm1Anjm Cd74tm1Liz Cd74tm2Liz Cd74tm1Doi Cd74tm1Eae

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD74 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD74

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD74 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD74 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD74
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD74:
    hsa-miR-100* hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidCD74 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): CD74 (NM_001025158)
    Sino Biological Human cDNA Clone for CD74
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD74
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD74
    Sirion Biotech Customized lentivirus for stable overexpression of CD74 
                         Customized lentivirus expression plasmids for stable overexpression of CD74 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD74


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD74 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.76
    3Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF-mediated glucocorticoid regulation1.00
    4Allograft rejection
    Antigen processing and presentation0.37
    5Influenza A
    Herpes simplex infection0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CD74
        Immune response Antigen presentation by MHC class II
    Immune response MIF-mediated glucocorticoid regulation


    2 GeneGo (Thomson Reuters) Pathways for CD74
        Immune response Antigen presentation by MHC class II
    Immune response MIF-mediated glucocorticoid regulation


    3        Reactome Pathways for CD74
        Adaptive Immune System
    Immune System
    MHC class II antigen presentation


    3         Kegg Pathways  (Kegg details for CD74):
        Antigen processing and presentation
    Tuberculosis
    Herpes simplex infection


    CD74 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD74

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/102 Interacting proteins for CD74 (P042332, 3 ENSP000000095304) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235844P200362, 3, ENSP000003975874MINT-72790 I2D: score=2 STRING: ENSP00000397587
    HLA-DPA1P200362, 3, ENSP000003935664MINT-72790 I2D: score=2 STRING: ENSP00000393566
    ENSG00000168384P200362, 3MINT-72790 I2D: score=2 
    ENSG00000206291P200362, 3MINT-72790 I2D: score=2 
    ENSG00000224103P200362, 3MINT-72790 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0001516prostaglandin biosynthetic process IDA12782713
    GO:0001961positive regulation of cytokine-mediated signaling pathway IMP12782713
    GO:0002606positive regulation of dendritic cell antigen processing and presentation IEA--
    GO:0002792negative regulation of peptide secretion IDA19849849

    CD74 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD74 (HG2A)

    Search CenterWatch for drugs/clinical trials and news about CD74 / HG2A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD74 gene (3 alternative transcripts): 
    NM_001025158.2  NM_001025159.2  NM_004355.3  

    Unigene Cluster for CD74:

    CD74 molecule, major histocompatibility complex, class II invariant chain
    Hs.436568  [show with all ESTs]
    Unigene Representative Sequence: NM_001025159
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377795 ENST00000353334(uc003lsc.3 uc003lsd.3 uc003lse.3)
    ENST00000518797 ENST00000524315 ENST00000009530 ENST00000523208 ENST00000517752
    ENST00000522246 ENST00000523813 ENST00000523836 ENST00000517791 ENST00000522153

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD74:
    hsa-miR-100* hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidCD74 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK292076.1 AK297889.1 BC018726.1 BC024272.1 BT019505.1 K01144.1 M28590.1 X00497.1 

    24/128 DOTS entries (see all 128):

    DT.95168786  DT.95084994  DT.100698176  DT.100698189  DT.100698208  DT.100698160  DT.91907489  DT.95197626 
    DT.91683190  DT.100698162  DT.120882966  DT.100698197  DT.92062429  DT.100875340  DT.95105083  DT.95168827 
    DT.100698182  DT.100698203  DT.100698173  DT.95168831  DT.100894778  DT.120883210  DT.100864559  DT.91681063 

    24/4731 AceView cDNA sequences (see all 4731):

    AA463925 BP359864 BP338857 BP348089 BP338262 BM456238 BP340541 BF795572 
    CB144197 AW084773 CR625117 BM454368 BG397411 BF975667 BQ548708 BU557012 
    CD515358 BP367243 AI827034 AA464506 BP340241 BM694914 H71748 BP338414 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CD74 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b
    SP1:                    -                       -                 -     -                       -     -                 -     -                                 
    SP2:                    -                       -                 -     -                       -     -     -           -     -                                 
    SP3:                    -                       -                 -     -                       -     -     -           -     -     -     -     -               
    SP4:                    -                       -                 -     -                       -     -                                                         
    SP5:                    -                       -                 -     -                       -     -     -                                                   


    ECgene alternative splicing isoforms for CD74

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD74 expression in normal human tissues (normalized intensities)      CD74 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCACATTA
    CD74 Expression
    About this image


    CD74 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 16 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Peripheral blood Pan-T Cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Cord Blood Pan-T Cells   
     
     Mesenchymal Stem Cells (Muscoskeletal System)    fully expand to see all 3 entries
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Human Hippocampal Astrocytes   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Fetal Liver CD36+ Cells   

    See CD74 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD74

    SOURCE GeneReport for Unigene cluster: Hs.436568
        SABiosciences Expression via Pathway-Focused PCR Arrays including CD74 (see all 6): 
              HIV Host Response in human mouse rat
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD74 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd741 , 5 CD74 antigen (invariant polypeptide of major histocompatibility more1, 5 82.13(n)1
    77.34(a)1
      18 (34.41 cM)5
    161491  NM_001042605.11  NP_001036070.11 
     608038485 
    chicken
    (Gallus gallus)
    Aves CD741 CD74 molecule, major histocompatibility complex, class more 60.58(n)
    47.91(a)
      414741  NM_001001613.1  NP_001001613.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD746
    CD74 molecule, major histocompatibility complex, c...
    41(a)
    1 ↔ 1
    2(138852889-138871983)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.102512 Xenopus laevis transcribed sequence with moderate similarity more 94.59(n)    CD362892.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cd74a1 CD74 molecule, major histocompatibility complex, class more 46.82(n)
    34.42(a)
      58113  NM_131590.1  NP_571665.1 


    ENSEMBL Gene Tree for CD74 (if available)
    TreeFam Gene Tree for CD74 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD74 gene
    4 SIMAP similar genes for CD74 using alignment to 6 protein entries:     HG2A_HUMAN (see all proteins):
    CD74/ROS fusion    HLA-DR    R32    CD74-ROS1_C6

    CD74 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/361 SNPs in CD74 are shown (see all 361)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006211201,2
    --144936850(+) AACAA-/CAAAAA 3 -- int10--------
    rs100621971,2
    C,F--144936851(+) aacaaC/Aaaaaa 3 -- int1 trp31Minor allele frequency- A:0.50WA 2
    rs2005268401,2
    --144936865(+) AAAAA-/AACAAGAA 3 -- int10--------
    rs769254621,2
    C--144936867(+) AAAAAA/CAAGAA 3 -- int10--------
    rs1411437421,2
    --149780713(+) CTCCTC/GTTAAA 3 -- ds50010--------
    rs798176601,2
    C,F--149780717(+) TCTTAA/GAAAGA 3 -- ds50011Minor allele frequency- G:0.01NA 120
    rs594020301,2
    C,F--149780853(+) GACACG/AGAGGC 3 -- ds50013Minor allele frequency- A:0.11CSA WA 121
    rs790836531,2
    C,F--149780952(+) AGAAGA/GGCTTG 3 -- ds50012Minor allele frequency- G:0.08NA EA 240
    rs1469240121,2
    --149780958(+) GCTTGC/TGCTTA 3 -- ds50010--------
    rs732708651,2
    C,F--149781005(+) TGTTCG/CTGTGT 3 -- ds50012Minor allele frequency- C:0.03WA 120

    HapMap Linkage Disequilibrium report for CD74 (149781200 - 149792492 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CD74: --
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CD74

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142790    OMIM disorders: --

    UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233
  • Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the
    formation of a CD74-ROS1 chimeric protein

  • 20/29 diseases for CD74 (see all 29):    About MalaCards
    thymic epithelial neoplasm    gastroduodenitis    cervical squamous cell carcinoma    clear cell renal cell carcinoma
    tonsillitis    b-cell chronic lymphocytic leukemia    mantle cell lymphoma    vaccinia
    renal cell carcinoma    hiv type 1    influenza    multiple myeloma
    myeloma    type 1 diabetes    chronic lymphocytic leukemia    glioblastoma
    adenoma    hepatitis c    cervicitis    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for CD74:
    Lymphoma

    CD74 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CD74
    Human Genome Epidemiology (HuGE) Navigator: CD74 (6 documents)

    Export disorders for CD74 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD74 gene, integrated from 9 sources (see all 135):
    (articles sorted by number of sources associating them with CD74)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens. (PubMed id 3001652)1, 2, 3 Kudo J.... Saunders G.F. (1985)
    2. cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. (PubMed id 6324166)1, 2, 3 Claesson L.... Peterson P.A. (1983)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Fine mapping of the CELIAC2 locus on chromosome 5q31- q33 in the Finnish and Hungarian populations. (PubMed id 19845895)1, 4 Koskinen L.L....Saavalainen P. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. MIF signal transduction initiated by binding to CD74. (PubMed id 12782713)1, 2 Leng L.... Bucala R. (2003)
    7. Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S. (PubMed id 10022822)1, 2 Guncar G....Turk D. (1999)
    8. Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii. (PubMed id 9843486)1, 2 Jasanoff A.... Wiley D.C. (1998)
    9. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. (PubMed id 7477400)1, 2 Ghosh P.... Wiley D.C. (1995)
    10. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. (PubMed id 1448172)1, 2 Riberdy J.M.... Cresswell P. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 972 HGNC: 1697 AceView: CD74 Ensembl:ENSG00000019582 euGenes: HUgn972
    ECgene: CD74 Kegg: 972 H-InvDB: CD74

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD74 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD74 gene:
    Search GeneIP for patents involving CD74

    Licensable Technologies for CD74 gene:
    Weizmann Institute:Regulation of B-CLL survival (CD74 and CD84 as regulators in tumor cells)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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