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CD74 Gene

protein-coding   GIFtS: 67
GCID: GC05M149753

CD74 Molecule, Major Histocompatibility Complex, Class II...

(Previous names: CD74 antigen (invariant polypeptide of major histocompatibility...)
(Previous symbol: DHLAG)
  See CD74-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD74 Molecule, Major Histocompatibility Complex, Class II Invariant
Chain1 2
     p332 3
DHLAG1 2 3 5     HLADG2
CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex,
Class II Antigen-Associated)1 2
     II2
HLA-DR-gamma1 2     Ia-GAMMA2
Gamma Chain Of Class II Antigens1 2     HLA Class II Histocompatibility Antigen Gamma Chain2
Ia-Associated Invariant Chain1 2     Ii3
MHC HLA-DR Gamma Chain1 2     CD74 Antigen3
HLA-DR Antigens-Associated Invariant Chain2 3     Ia Antigen-Associated Invariant Chain3

External Ids:    HGNC: 16971   Entrez Gene: 9722   Ensembl: ENSG000000195827   OMIM: 1427905   UniProtKB: P042333   

Export aliases for CD74 gene to outside databases

Previous GC identifers: GC05M149850 GC05M150378 GC05M149764 GC05M149809 GC05M144928


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD74 Gene:
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an
important chaperone that regulates antigen presentation for immune response. It also serves as cell surface
receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein,
initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein
(APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants
encoding different isoforms have been identified. (provided by RefSeq, Aug 2011)

GeneCards Summary for CD74 Gene:
CD74 (CD74 molecule, major histocompatibility complex, class II invariant chain) is a protein-coding gene. Diseases associated with CD74 include thymic epithelial neoplasm. GO annotations related to this gene include cytokine receptor activity and identical protein binding.

UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233
Function: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta
heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic
reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC
class II takes place. Serves as cell surface receptor for the cytokine MIF

Gene Wiki entry for CD74 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD74 gene promoter:
         Pax-6   AP-2gamma   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CD74 promoter sequence
   Search Chromatin IP Primers for CD74

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

CD74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD74 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M149753:  view genomic region     (about GC identifiers)

Start:
149,781,200 bp from pter      End:
149,792,492 bp from pter
Size:
11,293 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen gamma chain  
Size: 296 amino acids; 33516 Da
Subunit: Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class
II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74
component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small
fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule
(alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to
release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules
Sequence caution: Sequence=AAA36304.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for CD74 (see all 12):
1A6A (3D)        1ICF (3D)        1IIE (3D)        1L3H (3D)        1MUJ (3D)        3PDO (3D)    
Secondary accessions: A8K7R1 B4DNE8 D3DQG3 D3DQG4 Q14597 Q29832 Q5U0J8 Q8SNA0 Q8WLP6
Alternative splicing: 3 isoforms:  P04233-1   P04233-2   P04233-3   

Explore the universe of human proteins at neXtProt for CD74: NX_P04233

Explore proteomics data for CD74 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans1
  • Ubiquitination2 at Lys159, Lys170
  • Glycosylation2 at Asn130, Asn136, Ser197, Thr203, Asn256, Ser281
  • Modification sites at PhosphoSitePlus

  • See CD74 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001020329.1  NP_001020330.1  NP_004346.1  

    ENSEMBL proteins: 
     ENSP00000367026   ENSP00000230685   ENSP00000430614   ENSP00000429024   ENSP00000009530  
     ENSP00000430654   ENSP00000429641   ENSP00000429478  
    Reactome Protein details: P04233

    CD74 Human Recombinant Protein Products:

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    Novus Biologicals CD74 Proteins
    Novus Biologicals CD74 Lysates
    Sino Biological Recombinant Protein for CD74
    Sino Biological Cell Lysate for CD74
    ProSpec Recombinant Protein for CD74
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD74 

    CD74 Antibody Products:

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    CD74 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CD74 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    4 InterPro protein domains:
     IPR000716 Thyroglobulin_1
     IPR022339 MHC_II-assoc_invar_chain
     IPR015386 MHC_II-assoc_invar/CLIP_MHC-bd
     IPR011988 MHC_II-assoc_invariant_trimer

    Graphical View of Domain Structure for InterPro Entry P04233

    ProtoNet protein and cluster: P04233

    1 Blocks protein domain: IPB000716 Thyroglobulin type-1

    UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233
    Similarity: Contains 1 thyroglobulin type-1 domain


    Find genes that share domains with CD74           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HG2A_HUMAN, P04233
    Function: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta
    heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic
    reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC
    class II takes place. Serves as cell surface receptor for the cytokine MIF

         Genatlas biochemistry entry for CD74:
    cell differentiation antigen CD74,MHC class II associated invariant chain,identified by monoclonal antibodies
    LN2,BU-43,BU-45,chain Ii,31kDa

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IPI19849849
    GO:0004896cytokine receptor activity IDA17045821
    GO:0005515protein binding IPI19665027
    GO:0019955cytokine binding IPI12782713
    GO:0035718macrophage migration inhibitory factor binding IPI17045821
         
    Find genes that share ontologies with CD74           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD74:
     Decreased TP53 protein express  Decreased viability of wild-ty 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cd74):
     cellular  growth/size/body  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with CD74           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD74: Cd74tm1Anjm Cd74tm1Liz Cd74tm2Liz Cd74tm1Doi Cd74tm1Eae

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD74
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD74

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD74
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD74

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CD74:
    hsa-miR-100* hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidCD74 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD74
    Predesigned siRNA for gene silencing in human, mouse, rat CD74

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): CD74 (NM_001025158)
    Sino Biological Human cDNA Clone for CD74
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD74
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD74

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CD74 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD74


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HG2A_HUMAN, P04233: Cell membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum
    membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of
    intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    golgi apparatus4
    nucleus2
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005622intracellular TAS12782713
    GO:0005764lysosome ----
    GO:0005765lysosomal membrane TAS--
    GO:0005770late endosome ----

    Find genes that share ontologies with CD74           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD74 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.46
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Allograft rejection
    Antigen processing and presentation0.36
    4Influenza A
    Herpes simplex infection0.33
    5Tuberculosis
    Tuberculosis


    Find genes that share SuperPaths with CD74           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CD74
        Immune response Antigen presentation by MHC class II
    Immune response MIF-mediated glucocorticoid regulation


    1 Reactome Pathway for CD74
        MHC class II antigen presentation


    3 Kegg Pathways  (Kegg details for CD74):
        Antigen processing and presentation
    Tuberculosis
    Herpes simplex infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD74 (see all 6): 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antigen Presenting Cells in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD74

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD74 (P042331, 2, 3 ENSP000000095304) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235844P200362, 3, ENSP000003975874MINT-72790 I2D: score=2 STRING: ENSP00000397587
    HLA-DPA1P200362, 3, ENSP000003935664MINT-72790 I2D: score=2 STRING: ENSP00000393566
    ENSG00000168384P200362, 3MINT-72790 I2D: score=2 
    ENSG00000206291P200362, 3MINT-72790 I2D: score=2 
    ENSG00000224103P200362, 3MINT-72790 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0001516prostaglandin biosynthetic process IDA12782713
    GO:0001961positive regulation of cytokine-mediated signaling pathway IMP12782713
    GO:0002606positive regulation of dendritic cell antigen processing and presentation IEA--
    GO:0002792negative regulation of peptide secretion IDA19849849

    Find genes that share ontologies with CD74           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD74 (HG2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD74 gene (3 alternative transcripts): 
    NM_001025158.2  NM_001025159.2  NM_004355.3  

    Unigene Cluster for CD74:

    CD74 molecule, major histocompatibility complex, class II invariant chain
    Hs.436568  [show with all ESTs]
    Unigene Representative Sequence: NM_001025159
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377795 ENST00000353334(uc003lsc.3 uc003lsd.3 uc003lse.3)
    ENST00000518797 ENST00000524315 ENST00000009530 ENST00000523208 ENST00000517752
    ENST00000522246 ENST00000523813 ENST00000523836 ENST00000517791 ENST00000522153

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CD74:
    hsa-miR-100* hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidCD74 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD74
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CD74 (NM_001025158)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD74
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD74
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD74
      QuantiTect SYBR Green Assays in human, mouse, rat CD74
      QuantiFast Probe-based Assays in human, mouse, rat CD74

    Additional mRNA sequence: 

    AK292076.1 AK297889.1 BC018726.1 BC024272.1 BT019505.1 K01144.1 M28590.1 X00497.1 

    Selected DOTS entries (see all 128):

    DT.95168786  DT.95084994  DT.100698176  DT.100698189  DT.100698208  DT.100698160  DT.91907489  DT.95197626 
    DT.91683190  DT.100698162  DT.120882966  DT.100698197  DT.92062429  DT.100875340  DT.95105083  DT.95168827 
    DT.100698182  DT.100698203  DT.100698173  DT.95168831  DT.100894778  DT.120883210  DT.100864559  DT.91681063 

    Selected AceView cDNA sequences (see all 4731):

    AI827034 BG685714 BP362030 AA985611 BG236486 BP340001 BQ691051 AI720719 
    BQ709920 BP341046 BM710577 AU139533 CA447955 BU149491 BP339564 BQ712622 
    BG397343 BQ060921 BG754218 BG753920 BG397838 BP367348 BU947516 BP367993 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD74 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^ 12a · 12b
    SP1:                    -                       -                 -     -                       -     -                 -     -                                 
    SP2:                    -                       -                 -     -                       -     -     -           -     -                                 
    SP3:                    -                       -                 -     -                       -     -     -           -     -     -     -     -               
    SP4:                    -                       -                 -     -                       -     -                                                         
    SP5:                    -                       -                 -     -                       -     -     -                                                   


    ECgene alternative splicing isoforms for CD74

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD74 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCACATTA
    CD74 Expression
    About this image


    CD74 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
             Anterior astroglia-like cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
    CD74 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD74 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436568
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD74 (see all 6): 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Antigen Presenting Cells in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD74 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd741 , 5 CD74 antigen (invariant polypeptide of major histocompatibility more1, 5 82.13(n)1
    77.34(a)1
      18 (34.41 cM)5
    161491  NM_001042605.11  NP_001036070.11 
     608038485 
    chicken
    (Gallus gallus)
    Aves CD741 CD74 molecule, major histocompatibility complex, class more 60.58(n)
    47.91(a)
      414741  NM_001001613.1  NP_001001613.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD746
    CD74 molecule, major histocompatibility complex, c...
    42(a)
    1 ↔ 1
    2(138852889-138871983)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.102512 Xenopus laevis transcribed sequence with moderate similarity more 94.59(n)    CD362892.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cd74a6
    CD74 molecule, major histocompatibility complex, c...
    30(a)
    1 ↔ 1
    14(3122605-3136493) ENSDARG00000009087


    ENSEMBL Gene Tree for CD74 (if available)
    TreeFam Gene Tree for CD74 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD74 gene
    4 SIMAP similar genes for CD74 using alignment to 6 protein entries:     HG2A_HUMAN (see all proteins):
    CD74/ROS fusion    HLA-DR    R32    CD74-ROS1_C6

    Find genes that share paralogs with CD74           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD74 (see all 361)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006211201,2
    --144936850(+) AACAA-/CAAAAA 3 -- int10--------
    rs100621971,2
    C,F--144936851(+) aacaaC/Aaaaaa 3 -- int1 trp31Minor allele frequency- A:0.50WA 2
    rs2005268401,2
    --144936865(+) AAAAA-/AACAAGAA 3 -- int10--------
    rs769254621,2
    C--144936867(+) AAAAAA/CAAGAA 3 -- int10--------
    rs1411437421,2
    --149780713(+) CTCCTC/GTTAAA 3 -- ds50010--------
    rs798176601,2
    C,F--149780717(+) TCTTAA/GAAAGA 3 -- ds50011Minor allele frequency- G:0.01NA 120
    rs594020301,2
    C,F--149780853(+) GACACG/AGAGGC 3 -- ds50013Minor allele frequency- A:0.11CSA WA 121
    rs790836531,2
    C,F--149780952(+) AGAAGA/GGCTTG 3 -- ds50012Minor allele frequency- G:0.08NA EA 240
    rs1469240121,2
    --149780958(+) GCTTGC/TGCTTA 3 -- ds50010--------
    rs732708651,2
    C,F--149781005(+) TGTTCG/CTGTGT 3 -- ds50012Minor allele frequency- C:0.03WA 120

    HapMap Linkage Disequilibrium report for CD74 (149781200 - 149792492 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CD74: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD74
    DNA2.0 Custom Variant and Variant Library Synthesis for CD74

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142790    OMIM disorders: --

    UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233
  • Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the
    formation of a CD74-ROS1 chimeric protein

  • 1 disease for CD74:    
    About MalaCards
    thymic epithelial neoplasm

    1 disease from the University of Copenhagen DISEASES database for CD74:
    Lymphoma

    Find genes that share disorders with CD74           About GenesLikeMe

    Genetic Association Database (GAD): CD74
    Human Genome Epidemiology (HuGE) Navigator: CD74 (6 documents)

    Export disorders for CD74 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD74 gene, integrated from 10 sources (see all 137):
    (articles sorted by number of sources associating them with CD74)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens. (PubMed id 3001652)1, 2, 3 Kudo J.... Saunders G.F. (Nucleic Acids Res. 1985)
    2. cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. (PubMed id 6324166)1, 2, 3 Claesson L.... Peterson P.A. (Proc. Natl. Acad. Sci. U.S.A. 1983)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PubMed id 19845895)1, 4 Koskinen L.L....Saavalainen P. (Tissue Antigens 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. MIF signal transduction initiated by binding to CD74. (PubMed id 12782713)1, 2 Leng L.... Bucala R. (J. Exp. Med. 2003)
    7. Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S. (PubMed id 10022822)1, 2 Guncar G.... Turk D. (EMBO J. 1999)
    8. Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii. (PubMed id 9843486)1, 2 Jasanoff A.... Wiley D.C. (EMBO J. 1998)
    9. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. (PubMed id 7477400)1, 2 Ghosh P.... Wiley D.C. (Nature 1995)
    10. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. (PubMed id 1448172)1, 2 Riberdy J.M.... Cresswell P. (Nature 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 972 HGNC: 1697 AceView: CD74 Ensembl:ENSG00000019582 euGenes: HUgn972
    ECgene: CD74 Kegg: 972 H-InvDB: CD74

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD74 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD74 gene:
    Search GeneIP for patents involving CD74

    Licensable Technologies for CD74 gene:
    Weizmann Institute:Regulation of B-CLL survival (CD74 and CD84 as regulators in tumor cells)
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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