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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD74 Gene

protein-coding GIFtS: 67
GCID: GC05M149753

CD74 molecule, major histocompatibility complex, class II...

(Previous names: CD74 antigen (invariant polypeptide of major histocompatibility...)
(Previous symbol: DHLAG)

Explore 20 diseases affiliated with
CD74 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD74 Molecule, Major Histocompatibility Complex, Class II Invariant Chain¹ ²		Ia-GAMMA²
DHLAG¹ ² ³ ⁵		Gamma Chain Of Class II Antigens²
CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex, Class II Antigen-Associated)¹ ²		HLA Class II Histocompatibility Antigen Gamma Chain²
HLA-DR Antigens-Associated Invariant Chain² ³		Ia-Associated Invariant Chain²
P33¹		MHC HLA-DR Gamma Chain²
HLA-DR-Gamma¹		Ii³
HLADG²		CD74 Antigen³
II²		Ia Antigen-Associated Invariant Chain³

External Ids:	HGNC: 1697¹	Entrez Gene: 972²	Ensembl: ENSG00000019582⁷	OMIM: 142790⁵	UniProtKB: P04233³

Export aliases for CD74 gene to outside databases

Previous GC identifers: GC05M149850 GC05M150378 GC05M149764 GC05M149809 GC05M144928

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD74:

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important

chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the

cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival

pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the

production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms

have been identified. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233

Function: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta

heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic

reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC

class II takes place. Serves as cell surface receptor for the cytokine MIF

Gene Wiki entry for CD74

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD74 gene promoter:
Pax-6 AP-2gamma NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CD74 promoter sequence

Search SABiosciences Chromatin IP Primers for CD74

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD74

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q32

CD74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD74 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M149753: view genomic region (about GC identifiers)

Start:	149,781,200 bp from pter	End:	149,792,492 bp from pter
Size:	11,293 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen gamma chain

Size: 296 amino acids; 33516 Da

Subunit: Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II

molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or

HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes

sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP

(class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This

processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of

antigenic peptides to the MHC class II molecules

Subcellular location: Cell membrane; Single-pass type II membrane protein (Potential). Endoplasmic reticulum membrane.

Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments

in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane

Sequence caution: Sequence=AAA36304.1; Type=Erroneous initiation;

6/12 PDB 3D structures from and Proteopedia for CD74 (see all 12):

1A6A (3D)

1ICF (3D)

1IIE (3D)

1L3H (3D)

1MUJ (3D)

3PDO (3D)

Secondary accessions: A8K7R1 B4DNE8 D3DQG3 D3DQG4 Q14597 Q29832 Q5U0J8 Q8SNA0 Q8WLP6

Alternative splicing: 3 isoforms: P04233-1 P04233-2 P04233-3

Explore the universe of human proteins at neXtProt for CD74: NX_P04233

Post-translational modifications:

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04233

CD74 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001020329.1 NP_001020330.1 NP_004346.1

ENSEMBL proteins:

ENSP00000367026 ENSP00000230685 ENSP00000430614 ENSP00000429024 ENSP00000009530

ENSP00000430654 ENSP00000429641 ENSP00000429478

Reactome Protein details: P04233
Human Recombinant Protein Products:

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	Novus Biologicals CD74 Proteins Novus Biologicals CD74 Lysates
	Sino Biological Recombinant Protein for CD74
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD74

Gene Ontology (GO): 5/25 cellular component terms (GO ID links to tree view) (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005622	intracellular	TAS	12782713
GO:0005764	lysosome	--	--
GO:0005765	lysosomal membrane	TAS	--
GO:0005770	late endosome	--	--

CD74 for ontologies About GeneDecksing

CD74 Antibody Products:

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	Uscn Antibodies for CD74
	ThermoFisher Antibody for CD74

Assay Products for CD74:

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	GenScript Custom Assay Services for CD74
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	Uscn ELISAs and CLIAs for CD74

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD74 for domains About GeneDecksing

4 InterPro domains/families:

IPR000716 Thyroglobulin_1

IPR022339 MHC_II-assoc_invar_chain

IPR015386 MHC_II-assoc_invar/CLIP_MHC-bd

IPR011988 MHC_II-assoc_invariant_trimer

Graphical View of Domain Structure for InterPro Entry P04233

ProtoNet protein and cluster: P04233

1 Blocks protein family: IPB000716 Thyroglobulin type-1

UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233

Similarity: Contains 1 thyroglobulin type-1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233

Function: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta

heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic

reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC

class II takes place. Serves as cell surface receptor for the cytokine MIF

Genatlas biochemistry entry for CD74:

cell differentiation antigen CD74,MHC class II associated invariant chain,identified by monoclonal antibodies

LN2,BU-43,BU-45,chain Ii,31kDa

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CD74 Browse MicroRNA Expression Plasmids
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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD74 (see all 7) OriGene shRNA RFP: CD74 OriGene siRNA: CD74
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD74
		Search LifeMap BioReagents cell lines for CD74

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD74

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001540	beta-amyloid binding	IPI	19849849
GO:0004896	cytokine receptor activity	IDA	17045821
GO:0005515	protein binding	--	--
GO:0019955	cytokine binding	IPI	17567581
GO:0035718	macrophage migration inhibitory factor binding	IPI	17045821

CD74 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CD74:

Decreased TP53 protein express

Decreased viability of wild-ty

Animal Models:
Mouse knock-outs for CD74: Cd74^tm1Anjm Cd74^tm1Liz Cd74^tm2Liz Cd74^tm1Doi Cd74^tm1Eae
5 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Cd74):

cellular

growth/size

hematopoietic system

immune system

mortality/aging

CD74 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transport of MHC II:Ii complex along Golgi to TGN

Transport of MHC II:Ii complex to plasma membrane	1.00	Trafficking of nonameric complex in the endocytic pathway	1.00
Transport of MHC II:Ii complex along Golgi to TGN	1.00	Internalization of MHC II:Ii clathrin coated vesicle	0.52
Insertion of MHC II:Ii complex in to the plasma membrane	1.00

Immune response_Antigen presentation by MHC class II

Immune response_Antigen presentation by MHC class II

1.00

Immune response Antigen presentation by MHC class II

0.76

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Mucin expression in CF via IL-6, IL-17 signaling pathways

Immune response MIF-mediated glucocorticoid regulation

0.28

Immune response_MIF-mediated glucocorticoid regulation

0.28

Tuberculosis

Tuberculosis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CD74

	Immune response Antigen presentation by MHC class II
	Immune response MIF-mediated glucocorticoid regulation

2 GeneGo (Thomson Reuters) Pathways for CD74

	Immune response Antigen presentation by MHC class II
	Immune response MIF-mediated glucocorticoid regulation

5/8 Reactome Pathways for CD74 (see all 8)

	Internalization of MHC II:Ii clathrin coated vesicle
	Adaptive Immune System
	Trafficking of nonameric complex in the endocytic pathway
	Transport of MHC II:Ii complex along Golgi to TGN
	Transport of MHC II:Ii complex to plasma membrane

2 Kegg Pathways (Kegg details for CD74):

	Antigen processing and presentation
	Tuberculosis

CD74 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD74

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/87 Interacting proteins for CD74 (P04233^{2, 3} ENSP00000009530⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 87)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HLA-DQA1	P01909²^,³, ENSP00000339398⁴	MINT-72791 I2D: score=2 STRING: ENSP00000339398
ENSG00000206305	P01909²^,³	MINT-72791 I2D: score=2
ENSG00000232062	P01909²^,³	MINT-72791 I2D: score=2
CXCR4	P61073²^,³, ENSP00000386884⁴	MINT-7234512 MINT-7234528 MINT-7234542 MINT-7234499 I2D: score=1 STRING: ENSP00000386884
ENSG00000231286	P01920³, ENSP00000382018⁴	I2D: score=1 STRING: ENSP00000382018

About this table

Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IEA	--
GO:0001516	prostaglandin biosynthetic process	IDA	12782713
GO:0001961	positive regulation of cytokine-mediated signaling pathway	IMP	12782713
GO:0002606	positive regulation of dendritic cell antigen processing and presentation	IEA	--
GO:0002792	negative regulation of peptide secretion	IDA	19849849

CD74 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD74
Search CenterWatch for drugs/clinical trials and news about CD74 / HG2A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD74 gene (3 alternative transcripts):

NM_001025158.2 NM_001025159.2 NM_004355.3

Unigene Cluster for CD74:

CD74 molecule, major histocompatibility complex, class II invariant chain

Hs.436568 [show with all ESTs]

Unigene Representative Sequence: NM_001025159

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377795 ENST00000353334(uc003lsc.3 uc003lsd.3 uc003lse.3)

ENST00000518797 ENST00000524315 ENST00000009530 ENST00000523208 ENST00000517752

ENST00000522246 ENST00000523813 ENST00000523836 ENST00000517791 ENST00000522153

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CD74 Browse OriGene MicroRNA Expression Plasmids
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		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD74:
		hsa-miR-100* hsa-miR-1291
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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD74 (see all 7) OriGene shRNA RFP: CD74 OriGene siRNA: CD74
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Additional cDNA sequence:

AK292076.1 AK297889.1 BC018726.1 BC024272.1 BT019505.1 K01144.1 M28590.1 X00497.1

24/128 DOTS entries (see all 128):

DT.95168786 DT.95084994 DT.100698176 DT.100698189 DT.100698208 DT.100698160 DT.91907489 DT.95197626

DT.91683190 DT.100698162 DT.120882966 DT.100698197 DT.92062429 DT.100875340 DT.95105083 DT.95168827

DT.100698182 DT.100698203 DT.100698173 DT.95168831 DT.100894778 DT.120883210 DT.100864559 DT.91681063

24/4731 AceView cDNA sequences (see all 4731):

BG758698 BQ638265 BQ063551 BE561397 BG106086 BG755180 BP368181 BG753898

BM477170 BM464694 BP367793 BM875494 BG340459 BF914638 BP339968 BF725306

BP347629 BP339857 BP338052 BM457737 BF795843 BM849321 CD514954 CD246088

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CD74 (see all 14) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c	^	12a	·	12b
SP1:							-								-						-		-								-		-						-		-
SP2:							-								-						-		-								-		-		-				-		-
SP3:							-								-						-		-								-		-		-				-		-		-		-		-
SP4:							-								-						-		-								-		-
SP5:							-								-						-		-								-		-		-

ECgene alternative splicing isoforms for CD74

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD74 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCACATTA

About this image

CD74 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Umbilical Cord

Umbilical Veins

Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

See CD74 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD74

SOURCE GeneReport for Unigene cluster: Hs.436568

SABiosciences Expression via Pathway-Focused PCR Arrays including CD74 (see all 6):

HIV Host Response in human mouse rat

Cell Surface Markers in human mouse rat

NFKB Signaling Targets in human mouse rat

Antigen Presenting Cells in human mouse rat

T-cell & B-cell Activation in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD74

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD74 gene from 5/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd74^{1 , 5}	CD74 antigen (invariant polypeptide of major histocompatibility more^{1, 5}	82.13(n)¹ 77.34(a)¹		18 (34.41 cM)⁵ 16149¹ NM_001042605.1¹ NP_001036070.1¹ 60803848⁵
chicken (Gallus gallus)	Aves	CD74¹	CD74 molecule, major histocompatibility complex, class more	60.58(n) 47.91(a)		414741 NM_001001613.1 NP_001001613.1
lizard (Anolis carolinensis)	Reptilia	CD74⁶	--	42(a)	1 ↔ 1	2(138857471-138869697)
African clawed frog (Xenopus laevis)	Amphibia	Xl.10251²	Xenopus laevis transcribed sequence with moderate similarity more	94.59(n)		CD362892.1
zebrafish (Danio rerio)	Actinopterygii	cd74a¹	CD74 molecule, major histocompatibility complex, class more	46.82(n) 34.42(a)		58113 NM_131590.1 NP_571665.1

ENSEMBL Gene Tree for CD74 (if available)
TreeFam Gene Tree for CD74 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73270867^1,2	C,	--	144929512(+)	`CTGCTC/TAGGTC`	3	--	int¹		2		WA	120
rs79757528^1,2	F,	--	144929576(+)	`CCTTCG/ATCTGT`	3	--	int¹		1		WA	118
rs7722480^1,2	C,F,A,H,	--	144930001(+)	`TGGCGC/AGTGGA`	3	--	int¹		23		NS EA NA CSA WA	2646
rs77528881^1,2	F,	--	144930197(+)	`GAGGGG/AACCTC`	3	--	int¹		1		WA	118
rs111993603^1,2		--	144930666(+)	`GTCCAA/GTTCAC`	3	--	int¹		0	--	--	--	--
rs762800^1,2	F	--	144931538(-)	`GTACAC/GGACAG`	3	--	int¹		1		MN	184
rs74454446^1,2		--	144931720(+)	`ATTCCG/ACGGTG`	3	--	int¹		2		CSA WA	120
rs112156141^1,2	C	--	144931822(+)	`CCTGTA/C/TCCTTT`	3	--	spd¹ int¹		1		CSA	1
rs113535422^1,2	C	--	144931823(+)	`CTGTAC/G/TCTTTC`	3	--	spd¹ int¹		1		CSA	1
rs11548081^1,2	H	--	144932271(-)	`GAGAAC/ACTGAG`	5	/K /N	mis¹ int¹		4		NS EA	400

HapMap Linkage Disequilibrium report for CD74 (149781200 - 149792492 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD74: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD74

DNA2.0 Custom Variant and Variant Library Synthesis for CD74

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CD74 for disorders About GeneDecksing

OMIM gene information: 142790 OMIM disorders: --

UniProtKB/Swiss-Prot: HG2A_HUMAN, P04233

Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation

of a CD74-ROS1 chimeric protein

20 diseases for CD74: About MalaCards

clear cell renal cell carcinoma renal cell carcinoma chronic lymphocytic leukemia lymphocytic leukemia

gastroduodenitis multiple myeloma hepatocellular carcinoma tonsillitis

vaccinia myeloma carcinoma influenza

leukemia lung cancer prostate cancer glioblastoma

adenoma prostatitis tuberculosis immunodeficiency

1 disease from the University of Copenhagen DISEASES database for CD74:

Lymphoma

Human Genome Epidemiology (HuGE) Navigator: CD74 (6 documents)

Export disorders for CD74 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CD74 gene, integrated from 9 sources (see all 129):
(articles sorted by number of sources associating them with CD74)

Utopia: connect your pdf to the dynamic
world of online information

Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens. (PubMed id 3001652)^{1, 2, 3} Kudo J.... Saunders G.F. (1985)
cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. (PubMed id 6324166)^{1, 2, 3} Claesson L.... Peterson P.A. (1983)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
MIF signal transduction initiated by binding to CD74. (PubMed id 12782713)^{1, 2} Leng L.... Bucala R. (2003)
Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S. (PubMed id 10022822)^{1, 2} Guncar G....Turk D. (1999)
Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii. (PubMed id 9843486)^{1, 2} Jasanoff A.... Wiley D.C. (1998)
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. (PubMed id 7477400)^{1, 2} Ghosh P.... Wiley D.C. (1995)
HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. (PubMed id 1448172)^{1, 2} Riberdy J.M.... Cresswell P. (1992)
Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes. (PubMed id 3459184)^{1, 2} O'Sullivan D.M....Quaranta V. (1986)
The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity. (PubMed id 6586420)^{1, 2} Strubin M.... Long E.O. (1984)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 972	HGNC: 1697	AceView: CD74	Ensembl:ENSG00000019582	euGenes: HUgn972
ECgene: CD74	Kegg: 972	H-InvDB: CD74

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CD74	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CD74 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD74 gene:
Search GeneIP for patents involving CD74

Licensable Technologies for CD74 gene:

Weizmann Institute:

Regulation of B-CLL survival (CD74 and CD84 as regulators in tumor cells)

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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