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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD72 Gene

protein-coding   GIFtS: 60
GCID: GC09M035599

CD72 Molecule

(Previous name: CD72 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD72 Molecule1 2     B-Cell Differentiation Antigen CD722
CD72 Antigen1 2 3     lyb-22
LYB22 5     Lyb-23
CD72b2     

External Ids:    HGNC: 16961   Entrez Gene: 9712   Ensembl: ENSG000001371017   OMIM: 1072725   UniProtKB: P218543   

Export aliases for CD72 gene to outside databases

Previous GC identifers: GC09M035922 GC09M035779


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CD72 Gene: 
CD72 (CD72 molecule) is a protein-coding gene. Diseases associated with CD72 include sjogren's syndrome, and chronic lymphocytic leukemia, and among its related super-pathways are BCR signaling pathway and Axon guidance. GO annotations related to this gene include transmembrane signaling receptor activity and receptor binding.

UniProtKB/Swiss-Prot: CD72_HUMAN, P21854
Function: Plays a role in B-cell proliferation and differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD72 gene promoter:
         CREB   RP58   AML1a   deltaCREB   ZIC2/Zic2   Zic3   ITF-2   Tal-1beta   MRF-2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD72 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD72

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD72


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p

CD72 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD72 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035599:  view genomic region     (about GC identifiers)

Start:
35,609,530 bp from pter      End:
35,646,807 bp from pter
Size:
37,278 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD72_HUMAN, P21854 (See protein sequence)
Recommended Name: B-cell differentiation antigen CD72  
Size: 359 amino acids; 40220 Da
Subunit: Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1
(By similarity)
Subcellular location: Membrane; Single-pass type II membrane protein

Explore the universe of human proteins at neXtProt for CD72: NX_P21854

Explore proteomics data for CD72 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is
    important for interaction with PTPN6/SHP-1 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P21854

  • CD72 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD72 Protein Expression
    REFSEQ proteins: NP_001773.1  
    ENSEMBL proteins: 
     ENSP00000379980   ENSP00000367688   ENSP00000367687   ENSP00000259633  
    Reactome Protein details: P21854
    Human Recombinant Protein Products for CD72: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD72
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD72
    OriGene Protein Over-expression Lysate for CD72
    OriGene MassSpec for CD72 
    OriGene Custom Protein Services for CD72
    GenScript Custom Purified and Recombinant Proteins Services for CD72
    Novus Biologicals CD72 Protein
    Novus Biologicals CD72 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CD72
    Cloud-Clone Corp. Proteins for CD72 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA1711157

    CD72 for ontologies           About GeneDecksing



    CD72 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for CD72 
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    LSBio Antibodies in human, mouse, rat for CD72 

    Assay Products for CD72: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD72 
    Cloud-Clone Corp. CLIAs for CD72


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P21854

    ProtoNet protein and cluster: P21854

    UniProtKB/Swiss-Prot: CD72_HUMAN, P21854
    Similarity: Contains 1 C-type lectin domain


    CD72 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD72_HUMAN, P21854
    Function: Plays a role in B-cell proliferation and differentiation

         Genatlas biochemistry entry for CD72:
    cell differentiation antigen CD72,B cell surface protein,CD5 ligand,identified by monoclonal antibodies
    S-HCL2,Bu-40,Bu-41,J3-109;homologous to mouse Lyb-2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity NAS1711157
    GO:0005102receptor binding TAS1711157
    GO:0005515protein binding IPI1711157
    GO:0030246carbohydrate binding IEA--
         
    CD72 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd72):
     cellular  hematopoietic system  immune system 

    CD72 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd72tm1Jrp for CD72

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD72 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD72

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD72 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD72 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD72
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CD72:
    hsa-miR-548e hsa-miR-944 hsa-miR-4290 hsa-miR-548a-3p hsa-miR-661 hsa-miR-149 hsa-miR-3116 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidCD72 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CD72

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CD72 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD72


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD72 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3Sema4D in semaphorin signaling
    Semaphorin interactions0.41
    4Other semaphorin interactions
    Other semaphorin interactions
    5B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CD72
        B Cell Receptor Signaling Pathway
    BCR signaling pathway


    4        Reactome Pathways for CD72
        Developmental Biology
    Semaphorin interactions
    Other semaphorin interactions
    Axon guidance


    1         Kegg Pathway  (Kegg details for CD72):
        B cell receptor signaling pathway


    CD72 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD72

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for CD72 (P218543 ENSP000002596334) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD5P061273, ENSP000003426814I2D: score=3 STRING: ENSP00000342681
    SEMA4DQ928543, ENSP000003434184I2D: score=3 STRING: ENSP00000343418
    SYKP434053, ENSP000003648984I2D: score=1 STRING: ENSP00000364898
    PTPN6P293503, ENSP000003915924I2D: score=3 STRING: ENSP00000391592
    BLNKQ8WV283, ENSP000002243374I2D: score=3 STRING: ENSP00000224337
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS1711157
    GO:0007411axon guidance TAS--

    CD72 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD72 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD72

    2 Novoseek inferred chemical compound relationships for CD72 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 26.1 4 9237109 (1), 16581823 (1)
    thymidine 11.1 1 9576009 (1)

    Search CenterWatch for drugs/clinical trials and news about CD72

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD72 gene: 
    NM_001782.2  

    Unigene Cluster for CD72:

    CD72 molecule
    Hs.116481  [show with all ESTs]
    Unigene Representative Sequence: AB209587
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396757 ENST00000490239(uc010mkt.1 uc010mkv.2) ENST00000463720
    ENST00000477364 ENST00000378431 ENST00000470387 ENST00000465754(uc010mkw.1)
    ENST00000482121 ENST00000378430 ENST00000259633(uc003zxb.2 uc010mku.2)

    miRNA
    Products:
         
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CD72:
    hsa-miR-548e hsa-miR-944 hsa-miR-4290 hsa-miR-548a-3p hsa-miR-661 hsa-miR-149 hsa-miR-3116 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidCD72 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD72
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD72
    Clone
    Products:
         
    OriGene clones in human, mouse for CD72 (see all 11)
    OriGene ORF clones in mouse, rat for CD72
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD72 (NM_001782)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD72
    Sirion Biotech Customized lentivirus for stable overexpression of CD72 
                         Customized lentivirus expression plasmids for stable overexpression of CD72 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD72
    OriGene qSTAR qPCR primer pairs in human, mouse for CD72
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD72
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD72
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD72

    Additional mRNA sequence: 

    AB209587.1 AF283777.2 AK307305.1 AK309268.1 AK310093.1 AK310685.1 AK311283.1 BC011734.2 
    BC030227.1 DQ174771.1 M54992.1 

    15 DOTS entries:

    DT.100778017  DT.121160750  DT.121160771  DT.95097124  DT.95238474  DT.95238475  DT.92427353  DT.87078316 
    DT.97767867  DT.315694  DT.100741171  DT.100759593  DT.100778018  DT.100755357  DT.95201550 

    24/93 AceView cDNA sequences (see all 93):

    AW136790 BM129121 NM_001782 BI835399 BG392029 BQ231982 BQ642302 CK819468 
    BC030227 BE243454 BC011734 BE503923 CK819469 BM456677 CA309224 BI039379 
    BQ681609 BI766331 AU126432 BQ006239 BP368735 M54992 CR589985 BI906159 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CD72 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:                                                  -     -                 -     -           -     -                                 
    SP2:                                                                          -     -           -     -                                 
    SP3:                                                                          -     -           -     -                                 
    SP4:                                                  -     -                 -     -           -     -                                 
    SP5:                                                        -                 -     -           -     -                                 


    ECgene alternative splicing isoforms for CD72

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD72 expression in normal human tissues (normalized intensities)      CD72 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD72 Expression
    About this image


    CD72 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Immature B-Cells Peripheral Blood
             b cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules

    See CD72 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD72

    SOURCE GeneReport for Unigene cluster: Hs.116481

    UniProtKB/Swiss-Prot: CD72_HUMAN, P21854
    Tissue specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells

        SABiosciences Expression via Pathway-Focused PCR Array including CD72: 
              Cell Surface Markers in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD72
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD72

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD72 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd721 , 5 CD72 antigen1, 5 70.45(n)1
    56.1(a)1
      4 (23.04 cM)5
    125171  NM_007654.21  NP_031680.21 
     434464625 
    chicken
    (Gallus gallus)
    Aves --
    CD726
    (see all 3)
    CD72 antigen
    (see all 3)
    28(a)
    25(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    Z(8920541-8923636)
    Z(8924962-8928092)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    29(a)
    26(a)
    many → 1
    many → 1
    GL343585.1(338281-342900)
    GL343585.1(357172-406495)


    ENSEMBL Gene Tree for CD72 (if available)
    TreeFam Gene Tree for CD72 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/193 SNPs in CD72 are shown (see all 193)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424524701,2
    C,F--35610691(+) ACTCCA/GGTGTC 2 P L mis11Minor allele frequency- G:0.00NA 4552
    rs1173440111,2
    C,F--35610766(+) GTAAGG/ATAGAG 1 -- int12Minor allele frequency- A:0.02NA EU 1443
    rs2001010431,2
    --35610789(+) CTGGAC/TATATC 1 -- int10--------
    rs1837378371,2
    --35610793(+) ACATAC/TCCCAC 1 -- int10--------
    rs48799131,2
    C,F,A,H--35610912(+) AACAGG/ACTTTA 1 -- int127Minor allele frequency- A:0.43NS EA NA CSA WA 2772
    rs1884206731,2
    --35610935(+) GGAAAA/GATAAC 1 -- int10--------
    rs1812723741,2
    --35611001(+) CCCAGC/TACTTT 1 -- int10--------
    rs1513385061,2
    --35611015(+) AGGCCA/GAGGCG 1 -- int10--------
    rs1856926791,2
    --35611037(+) AGGTCA/GGGACA 1 -- int10--------
    rs109725271,2
    --35611200(+) ctgagA/Gttgca 1 -- int10--------

    HapMap Linkage Disequilibrium report for CD72 (35609530 - 35646807 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD72:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv528256CNV Loss19592680
    dgv8168n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): CD72
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107272    OMIM disorders: --

    12 diseases for CD72:    About MalaCards
    sjogren's syndrome    chronic lymphocytic leukemia    purpura    lupus erythematosus
    systemic lupus erythematosus    hepatitis b    type 1 diabetes    arthritis
    t-cell leukemia    leukemia    lymphoblastic leukemia    hepatitis


    CD72 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CD72 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 52.2 2 9576009 (1), 1384316 (1)
    lupus erythematosus systemic 34.2 3 15459183 (1), 17121583 (1), 14989715 (1)
    rheumatoid arthritis 1.86 1 14989715 (1)
    lymphoma 0 2 9576009 (1), 1384316 (1)

    Genetic Association Database (GAD): CD72
    Human Genome Epidemiology (HuGE) Navigator: CD72 (6 documents)

    Export disorders for CD72 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD72 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with CD72)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B. (PubMed id 15459183)1, 4, 9 Hitomi Y.... Tokunaga K. (2004)
    2. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PubMed id 1711157)1, 3, 9 van de Velde H.... Thielemans K. (1991)
    3. Identity of human Lyb-2 and CD72 and localization of the gene to chromosome 9. (PubMed id 2044654)1, 3, 9 Von Hoegen I....Parnes J.R. (1991)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. CD72 Polymorphism Associated with Child-Onset of Idiopathic Thrombocytopenic Purpura in Chinese Patients. (PubMed id 18071878)1, 4 Xu J....Yang R. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA. (PubMed id 2141045)1, 2 von Hoegen I.... Parnes J.R. (1990)
    8. Increased mutations of CD72 transcript in B-lymphocytes from adolescent patients with systemic lupus erythematosus. (PubMed id 17121583)1, 9 Kaneko U....Uchiyama M. (2006)
    9. CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72. (PubMed id 17786190)1, 9 Mizrahi S....Mandelboim O. (2007)
    10. Native soluble CD5 delivers a costimulatory signal to resting human B lymphocytes. (PubMed id 8806810)1, 9 Van de Velde H. and Thielemans K. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 971 HGNC: 1696 AceView: CD72 Ensembl:ENSG00000137101 euGenes: HUgn971
    ECgene: CD72 Kegg: 971 H-InvDB: CD72

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD72 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD72 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_237

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD72 gene:
    Search GeneIP for patents involving CD72

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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