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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD72 Gene

protein-coding   GIFtS: 60
GCID: GC09M035599

CD72 molecule

(Previous name: CD72 antigen )
 Explore 14 diseases affiliated with
CD72 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD72    

Aliases
for CD72 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD72 Molecule1 2     B-Cell Differentiation Antigen CD722
CD72 Antigen1 2 3     Lyb-23
LYB21 2 5     Lyb-23
CD72b1 2     

External Ids:    HGNC: 16961   Entrez Gene: 9712   Ensembl: ENSG000001371017   OMIM: 1072725   UniProtKB: P218543   

Export aliases for CD72 gene to outside databases

Previous GC identifers: GC09M035922 GC09M035779


Summaries
for CD72 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CD72_HUMAN, P21854
Function: Plays a role in B-cell proliferation and differentiation




Genomic Views
for CD72 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD72 gene promoter:
         CREB   RP58   AML1a   deltaCREB   ZIC2/Zic2   Zic3   ITF-2   Tal-1beta   MRF-2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD72 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD72

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD72


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p

CD72 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD72 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035599:  view genomic region     (about GC identifiers)

Start:
 35,609,530 bp from pter      End:
 35,646,807 bp from pter
Size:
 37,278 bases      Orientation:
 minus strand

Proteins
for CD72 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD72_HUMAN, P21854 (See protein sequence)
Recommended Name: B-cell differentiation antigen CD72  
Size: 359 amino acids; 40220 Da
Subunit: Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By
similarity)
Subcellular location: Membrane; Single-pass type II membrane protein

Explore the universe of human proteins at neXtProt for CD72: NX_P21854

Post-translational modifications:

  • Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important
    • for interaction with PTPN6/SHP-1 (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21854

    • CD72 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001773.1  
    ENSEMBL proteins: 
     ENSP00000379980   ENSP00000367688   ENSP00000367687   ENSP00000259633  
    Reactome Protein details: P21854
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for CD72
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CD72
    OriGene Protein Over-expression Lysate: CD72
    OriGene Custom Protein Services for CD72 
    GenScript Custom Purified and Recombinant Proteins Services for CD72
    Novus Biologicals CD72 Proteins
    Novus Biologicals CD72 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CD72
    Uscn Proteins for CD72

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA1711157


    CD72 for ontologies           About GeneDecksing



    CD72 Antibody Products: 
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    Abcam antibodies for CD72 
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    ThermoFisher Antibody for CD72

    Assay Products for CD72: 
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    Uscn ELISAs and CLIAs for CD72

    Protein Domains /
    Families
    for CD72 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD72 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P21854

    ProtoNet protein and cluster: P21854

    UniProtKB/Swiss-Prot: CD72_HUMAN, P21854
    Similarity: Contains 1 C-type lectin domain


    Function
    for CD72 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD72_HUMAN, P21854
    Function: Plays a role in B-cell proliferation and differentiation

         Genatlas biochemistry entry for CD72:
    cell differentiation antigen CD72,B cell surface protein,CD5 ligand,identified by monoclonal antibodies
    S-HCL2,Bu-40,Bu-41,J3-109;homologous to mouse Lyb-2

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CD72:
    hsa-miR-548e hsa-miR-944 hsa-miR-4290 hsa-miR-548a-3p hsa-miR-661 hsa-miR-149 hsa-miR-3116 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmid: CD72 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD72 (see all 7)
    OriGene shRNA RFP: CD72
    OriGene siRNA: CD72
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD72

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD72

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD72 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: CD72 (NM_001782)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD72 

    Cell Line
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    Search LifeMap BioReagents cell lines for CD72

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD72

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity NAS1711157
    GO:0005102receptor binding TAS1711157
    GO:0005515protein binding IPI1711157
    GO:0030246carbohydrate binding IEA--


    CD72 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cd72tm1Jrp for CD72
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cd72):
     cellular  hematopoietic system  immune system 

    CD72 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CD72 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2B cell receptor signaling pathway
    		B cell receptor signaling pathway1.00
    		BCR signaling pathway0.41
    3Sema4D in semaphorin signaling
    		Sema4D in semaphorin signaling1.00
    		Semaphorin interactions0.44
    4B Cell Receptor Signaling Pathway
    		B Cell Receptor Signaling Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for CD72 
        B Cell Receptor Signaling Pathway
    BCR signaling pathway

    4        Reactome Pathways for CD72
        Developmental Biology
    Semaphorin interactions
    Sema4D in semaphorin signaling
    Axon guidance


    1         Kegg Pathway  (Kegg details for CD72):
        B cell receptor signaling pathway


    CD72 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD72

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for CD72 (P218543 ENSP000002596334) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD5P061273, ENSP000003426814I2D: score=3 STRING: ENSP00000342681
    SEMA4DQ928543, ENSP000003434184I2D: score=3 STRING: ENSP00000343418
    SYKP434053, ENSP000003648984I2D: score=1 STRING: ENSP00000364898
    PTPN6P293503, ENSP000003915924I2D: score=3 STRING: ENSP00000391592
    BLNKQ8WV283, ENSP000002243374I2D: score=3 STRING: ENSP00000224337
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS1711157
    GO:0007411axon guidance TAS--


    CD72 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD72 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD72 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD72
    2 Novoseek chemical compound relationships for CD72 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 26.1 4 9237109 (1), 16581823 (1)
    thymidine 11.1 1 9576009 (1)

    Search CenterWatch for drugs/clinical trials and news about CD72 

    Transcripts
    for CD72 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD72 gene: 
    NM_001782.2  

    Unigene Cluster for CD72:

    CD72 molecule
    Hs.116481  [show with all ESTs]
    Unigene Representative Sequence: AB209587
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396757 ENST00000490239(uc010mkt.1 uc010mkv.2) ENST00000463720
    ENST00000477364 ENST00000378431 ENST00000465754(uc010mkw.1) ENST00000470387
    ENST00000482121 ENST00000378430 ENST00000259633(uc003zxb.2 uc010mku.2)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD72
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CD72:
    hsa-miR-548e hsa-miR-944 hsa-miR-4290 hsa-miR-548a-3p hsa-miR-661 hsa-miR-149 hsa-miR-3116 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmid: CD72 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD72 (see all 7)
    OriGene shRNA RFP: CD72
    OriGene siRNA: CD72
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD72
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD72 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD72
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CD72 (NM_001782)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD72 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD72
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD72
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD72

    Additional cDNA sequence: 

    AB209587.1 AF283777.2 AK307305.1 AK309268.1 AK310093.1 AK310685.1 AK311283.1 BC011734.2 
    BC030227.1 DQ174771.1 M54992.1 

    14 DOTS entries:

    DT.100778017  DT.121160750  DT.121160771  DT.95097124  DT.95238474  DT.95238475  DT.92427353  DT.87078316 
    DT.97767867  DT.315694  DT.100741171  DT.100759593  DT.100778018  DT.95201550 

    24/93 AceView cDNA sequences (see all 93):

    NM_001782 BQ681609 BC030227 BI835399 BQ642302 BG392029 AW136790 BM456677 
    M54992 CA309224 BI039379 BC011734 BQ231982 CR589985 BI766331 BE503923 
    BP368735 CK819469 AU126432 BM129121 CK819468 BE243454 BQ006239 BQ056430 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CD72 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:                                                  -     -                 -     -           -     -                                 
    SP2:                                                                          -     -           -     -                                 
    SP3:                                                                          -     -           -     -                                 
    SP4:                                                  -     -                 -     -           -     -                                 
    SP5:                                                        -                 -     -           -     -                                 


    ECgene alternative splicing isoforms for CD72

    Expression
    for CD72 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD72 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CD72 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BloodPeripheral BloodImmature B CellsBlood
    AdiposeBody Subcutaneous White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CD72 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD72

    SOURCE GeneReport for Unigene cluster: Hs.116481

    UniProtKB/Swiss-Prot: CD72_HUMAN, P21854
    Tissue specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells

        SABiosciences Expression via Pathway-Focused PCR Array including CD72: 
              Cell Surface Markers in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD72

    Orthologs
    for CD72 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CD72 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cd721 , 5 CD72 antigen1, 5 70.45(n)1
    56.1(a)1    		   4 (23.04 cM)5
    125171  NM_007654.21  NP_031680.21 
     434464625 
    chicken
    (Gallus gallus)    		 Aves CD726
    --
    (see all 3)    		 Uncharacterized protein
    (see all 3)    		 29(a)
    26(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 Z(8423047-8426804)
    Z(8426772-8430612)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 32(a)
    30(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 GL343585.1(399324-406415)
    GL343585.1(338281-342900)


    ENSEMBL Gene Tree for CD72 (if available)
    TreeFam Gene Tree for CD72 (if available) 

    Paralogs
    for CD72 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CD72 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/135 NCBI SNPs in CD72 are shown (see all 135)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1391652511,2
    		--35609843(+) ACCGGA/CTCTTC 2 -- ut31 ds50010--------
    rs2000027171,2
    		--35609942(+) ACCAG-/ACACAGC 2 -- ds5001 ut310--------
    rs37504291,2
    		C--35610055(-) TGGGGG/AAGGAG 2 -- ut31 ds5001 ese3 trp31Minor allele frequency- A:0.00NA 2
    rs1875240131,2
    		--35610059(+) TCCCCA/CACCCC 2 -- ds5001 ut310--------
    rs1438627251,2
    		--35610202(+) CAGCCA/GGTGGC 2 -- ut31 ds50010--------
    rs1930195761,2
    		--35610299(+) GTGTCG/TGGAAA 2 -- spa1 ds50010--------
    rs720557501,2
    		C,--35610316(+) GTATC-/AGTG  
                AGCTC     		2 -- ds5001 int10--------
    rs348575761,2
    		C--35610318(+) ATCAGTGAG/-  
                CTCCA     		2 -- int1 ds50011Minor allele frequency- -:0.50NA 2
    rs1856405891,2
    		--35610345(+) TGAACC/TCTCAT 2 -- int1 ds50010--------
    rs1486209271,2
    		--35610484(+) AGGAAC/GTTTCA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for CD72 (35609530 - 35646807 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CD72: --
    Human Gene Mutation Database (HGMD): CD72

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    Disorders / Diseases
    for CD72 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD72 for disorders           About GeneDecksing

    OMIM gene information: 107272    OMIM disorders: --

    14 diseases for CD72:    About MalaCards
    lupus erythematosus    systemic lupus erythematosus    rheumatoid arthritis    chronic lymphocytic leukemia
    lymphocytic leukemia    sjogren's syndrome    lymphoblastic leukemia    leukemia
    hepatitis b    purpura    arthritis    t-cell leukemia
    hepatitis    immunodeficiency

    4 Novoseek disease relationships for CD72 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 52.2 2 9576009 (1), 1384316 (1)
    lupus erythematosus systemic 34.2 3 15459183 (1), 17121583 (1), 14989715 (1)
    rheumatoid arthritis 1.86 1 14989715 (1)
    lymphoma 0 2 9576009 (1), 1384316 (1)

    Genetic Association Database (GAD): CD72
    Human Genome Epidemiology (HuGE) Navigator: CD72 (6 documents)

    Export disorders for CD72 gene to outside databases

    Publications
    for CD72 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD72 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with CD72)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B. (PubMed id 15459183)1, 4, 9 Hitomi Y.... Tokunaga K. (2004)
    2. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PubMed id 1711157)1, 3, 9 van de Velde H.... Thielemans K. (1991)
    3. Identity of human Lyb-2 and CD72 and localization of the gene to chromosome 9. (PubMed id 2044654)1, 3, 9 Von Hoegen I....Parnes J.R. (1991)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA. (PubMed id 2141045)1, 2 von Hoegen I.... Parnes J.R. (1990)
    6. Increased mutations of CD72 transcript in B-lymphocytes from adolescent patients with systemic lupus erythematosus. (PubMed id 17121583)1, 9 Kaneko U....Uchiyama M. (2006)
    7. CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72. (PubMed id 17786190)1, 9 Mizrahi S....Mandelboim O. (2007)
    8. Native soluble CD5 delivers a costimulatory signal to resting human B lymphocytes. (PubMed id 8806810)1, 9 Van de Velde H. and Thielemans K. (1996)
    9. Placental expression of CD100, CD72 and CD45 is dysreg ulated in human miscarriage. (PubMed id 22606231)1 Lorenzi T....Marzioni D. (2012)
    10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)

    External Searches for CD72 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CD72 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 971 HGNC: 1696 AceView: CD72 Ensembl:ENSG00000137101 euGenes: HUgn971
    ECgene: CD72 Kegg: 971 H-InvDB: CD72

    Other Databases showing CD72 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD72 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD72 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD72 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_237

    Intellectual Property
    for CD72 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD72 gene:
    Search GeneIP for patents involving CD72

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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