Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CD72 Gene

protein-coding   GIFtS: 60
GCID: GC09M035610

CD72 Molecule

(Previous name: CD72 antigen)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CD72 Molecule1 2     B-Cell Differentiation Antigen CD722
CD72 Antigen1 2 3     lyb-22
LYB22 5     Lyb-23
CD72b2     

External Ids:    HGNC: 16961   Entrez Gene: 9712   Ensembl: ENSG000001371017   OMIM: 1072725   UniProtKB: P218543   

Export aliases for CD72 gene to outside databases

Previous GC identifers: GC09M035922 GC09M035779 GC09M035599


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CD72 Gene:
CD72 (CD72 molecule) is a protein-coding gene. GO annotations related to this gene include transmembrane signaling receptor activity and receptor binding.

UniProtKB/Swiss-Prot: CD72_HUMAN, P21854
Function: Plays a role in B-cell proliferation and differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD72 gene promoter:
         CREB   RP58   AML1a   deltaCREB   ZIC2/Zic2   Zic3   ITF-2   Tal-1beta   MRF-2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD72 promoter sequence
   Search Chromatin IP Primers for CD72

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD72


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p

CD72 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD72 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035610:  view genomic region     (about GC identifiers)

Start:
35,609,530 bp from pter      End:
35,646,807 bp from pter
Size:
37,278 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CD72_HUMAN, P21854 (See protein sequence)
Recommended Name: B-cell differentiation antigen CD72  
Size: 359 amino acids; 40220 Da
Subunit: Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1
(By similarity)

Explore the universe of human proteins at neXtProt for CD72: NX_P21854

Explore proteomics data for CD72 at MOPED

Post-translational modifications: 

  • Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is
    important for interaction with PTPN6/SHP-1 (By similarity)1
  • Glycosylation2 at Asn136
  • Modification sites at PhosphoSitePlus

  • See CD72 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001773.1  
    ENSEMBL proteins: 
     ENSP00000379980   ENSP00000367688   ENSP00000367687   ENSP00000259633  
    Reactome Protein details: P21854

    CD72 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD72
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD72
    OriGene Protein Over-expression Lysate for CD72
    OriGene MassSpec for CD72
    OriGene Custom Protein Services for CD72
    GenScript Custom Purified and Recombinant Proteins Services for CD72
    Novus Biologicals CD72 Protein
    Novus Biologicals CD72 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CD72
    Cloud-Clone Corp. Proteins for CD72

     
    Search eBioscience for Proteins for CD72 

     
    antibodies-online proteins for CD72 (23 products) 

     
    antibodies-online peptides for CD72

    CD72 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD72
    OriGene Antibodies for CD72
    OriGene Custom Antibody Services for CD72
    Novus Biologicals CD72 Antibodies
    Abcam antibodies for CD72
    Cloud-Clone Corp. Antibodies for CD72
    ThermoFisher Antibodies for CD72
    antibodies-online antibodies for CD72 (105 products) 

    CD72 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD72
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD72
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD72
    Cloud-Clone Corp. CLIAs for CD72
    Search eBioscience for ELISAs for CD72 
    antibodies-online kits for CD72 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P21854

    ProtoNet protein and cluster: P21854

    UniProtKB/Swiss-Prot: CD72_HUMAN, P21854
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with CD72           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD72_HUMAN, P21854
    Function: Plays a role in B-cell proliferation and differentiation

         Genatlas biochemistry entry for CD72:
    cell differentiation antigen CD72,B cell surface protein,CD5 ligand,identified by monoclonal antibodies
    S-HCL2,Bu-40,Bu-41,J3-109;homologous to mouse Lyb-2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity NAS1711157
    GO:0005102receptor binding TAS1711157
    GO:0005515protein binding IPI1711157
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with CD72           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd72):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CD72           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cd72tm1Jrp for CD72

       genOway: Develop your customized and physiologically relevant rodent model for CD72

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CD72 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CD72:
    hsa-miR-548e hsa-miR-944 hsa-miR-4290 hsa-miR-548a-3p hsa-miR-661 hsa-miR-149 hsa-miR-3116 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidCD72 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD72
    Predesigned siRNA for gene silencing in human, mouse, rat CD72

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD72

    Clone
    Products:
         
    OriGene clones in human, mouse for CD72 (see all 10)
    OriGene ORF clones in mouse, rat for CD72
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD72 (NM_001782)
    Sino Biological Human cDNA Clone for CD72
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD72

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD72
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD72 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD72

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-13483) for CD72 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CD72_HUMAN, P21854: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA1711157

    Find genes that share ontologies with CD72           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CD72 About    
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3Semaphorin interactions
    Semaphorin interactions0.43
    Other semaphorin interactions0.00
    4B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway


    Find genes that share SuperPaths with CD72           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CD72
        B Cell Receptor Signaling Pathway
    BCR signaling pathway


    1 Reactome Pathway for CD72
        Other semaphorin interactions


    1 Kegg Pathway  (Kegg details for CD72):
        B cell receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including CD72: 
              Cell Surface Markers in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD72

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for CD72 (P218543 ENSP000002596334) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD5P061273, ENSP000003426814I2D: score=3 STRING: ENSP00000342681
    SEMA4DQ928543, ENSP000003434184I2D: score=3 STRING: ENSP00000343418
    SYKP434053, ENSP000003648984I2D: score=1 STRING: ENSP00000364898
    PTPN6P293503, ENSP000003915924I2D: score=3 STRING: ENSP00000391592
    BLNKQ8WV283, ENSP000002243374I2D: score=3 STRING: ENSP00000224337
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS1711157
    GO:0007165signal transduction NAS1711157
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with CD72           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD72

    2 Novoseek inferred chemical compound relationships for CD72 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 26.1 4 9237109 (1), 16581823 (1)
    thymidine 11.1 1 9576009 (1)



    Find genes that share compounds with CD72           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CD72 gene: 
    NM_001782.2  

    Unigene Cluster for CD72:

    CD72 molecule
    Hs.116481  [show with all ESTs]
    Unigene Representative Sequence: AB209587
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396757 ENST00000490239(uc010mkt.1 uc010mkv.2) ENST00000463720
    ENST00000477364 ENST00000378431 ENST00000470387 ENST00000465754(uc010mkw.1)
    ENST00000482121 ENST00000378430 ENST00000259633(uc003zxb.2 uc010mku.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD72 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CD72:
    hsa-miR-548e hsa-miR-944 hsa-miR-4290 hsa-miR-548a-3p hsa-miR-661 hsa-miR-149 hsa-miR-3116 hsa-miR-3652
    SwitchGear 3'UTR luciferase reporter plasmidCD72 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD72
    Predesigned siRNA for gene silencing in human, mouse, rat CD72
    Clone
    Products:
         
    OriGene clones in human, mouse for CD72 (see all 10)
    OriGene ORF clones in mouse, rat for CD72
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD72 (NM_001782)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD72
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD72
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD72
    OriGene qSTAR qPCR primer pairs in human, mouse for CD72
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD72
      QuantiTect SYBR Green Assays in human, mouse, rat CD72
      QuantiFast Probe-based Assays in human, mouse, rat CD72
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA6-13483) for CD72 

    Additional mRNA sequence: 

    AB209587.1 AF283777.2 AK307305.1 AK309268.1 AK310093.1 AK310685.1 AK311283.1 BC011734.2 
    BC030227.1 DQ174771.1 M54992.1 

    15 DOTS entries:

    DT.100778017  DT.121160750  DT.121160771  DT.95097124  DT.95238474  DT.95238475  DT.92427353  DT.87078316 
    DT.97767867  DT.315694  DT.100741171  DT.100759593  DT.100778018  DT.100755357  DT.95201550 

    Selected AceView cDNA sequences (see all 93):

    CK819469 CK819468 BP368735 BQ681609 BI039379 BE503923 M54992 BM129121 
    CA309224 BM456677 CR589985 AW136790 NM_001782 BC030227 BE243454 BG392029 
    BQ006239 BI835399 AU126432 BQ231982 BI766331 BQ642302 BC011734 BQ677442 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD72 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h · 2i ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:                                                  -     -                 -     -           -     -                                 
    SP2:                                                                          -     -           -     -                                 
    SP3:                                                                          -     -           -     -                                 
    SP4:                                                  -     -                 -     -           -     -                                 
    SP5:                                                        -                 -     -           -     -                                 


    ECgene alternative splicing isoforms for CD72

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CD72 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD72 Expression
    About this image


    CD72 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Immature B-Cells Peripheral Blood
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Tonsil (Hematopoietic System)
    CD72 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD72 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.116481

    UniProtKB/Swiss-Prot: CD72_HUMAN, P21854
    Tissue specificity: Pre-B-cells and B-cells but not terminally differentiated plasma cells

        Pathway & Disease-focused RT2 Profiler PCR Array including CD72: 
              Cell Surface Markers in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD72
    OriGene qSTAR qPCR primer pairs in human, mouse for CD72
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD72
    QuantiTect SYBR Green Assays in human, mouse, rat CD72
    QuantiFast Probe-based Assays in human, mouse, rat CD72
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD72

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CD72 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd721 , 5 CD72 antigen1, 5 70.35(n)1
    56.1(a)1
      4 (23.04 cM)5
    125171  NM_007654.21  NP_031680.21 
     434464625 
    chicken
    (Gallus gallus)
    Aves CHB16
    CD726
    (see all 3)
    Gallus gallus CD72 molecule (CD72), mRNA.
    (see all 3)
    23(a)
    11(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    Z(8915576-8919172)
    Z(8924962-8928092)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    31(a)
    29(a)
    many → 1
    many → 1
    GL343585.1(338281-342900)
    GL343585.1(357172-406495)


    ENSEMBL Gene Tree for CD72 (if available)
    TreeFam Gene Tree for CD72 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CD72 (see all 193)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424524701,2
    C,F--35610691(+) ACTCCA/GGTGTC 2 P L mis11Minor allele frequency- G:0.00NA 4552
    rs1173440111,2
    C,F--35610766(+) GTAAGG/ATAGAG 1 -- int12Minor allele frequency- A:0.02NA EU 1443
    rs2001010431,2
    --35610789(+) CTGGAC/TATATC 1 -- int10--------
    rs1837378371,2
    --35610793(+) ACATAC/TCCCAC 1 -- int10--------
    rs48799131,2
    C,F,A,H--35610912(+) AACAGG/ACTTTA 1 -- int127Minor allele frequency- A:0.43NS EA NA CSA WA 2772
    rs1884206731,2
    --35610935(+) GGAAAA/GATAAC 1 -- int10--------
    rs1812723741,2
    --35611001(+) CCCAGC/TACTTT 1 -- int10--------
    rs1513385061,2
    --35611015(+) AGGCCA/GAGGCG 1 -- int10--------
    rs1856926791,2
    --35611037(+) AGGTCA/GGGACA 1 -- int10--------
    rs109725271,2
    --35611200(+) ctgagA/Gttgca 1 -- int10--------

    HapMap Linkage Disequilibrium report for CD72 (35609530 - 35646807 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD72:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528256CNV Loss19592680
    dgv8168n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): CD72
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD72
    DNA2.0 Custom Variant and Variant Library Synthesis for CD72

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 107272    OMIM disorders: --


    Find genes that share disorders with CD72           About GenesLikeMe

    4 Novoseek inferred disease relationships for CD72 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 52.2 2 9576009 (1), 1384316 (1)
    lupus erythematosus systemic 34.2 3 15459183 (1), 17121583 (1), 14989715 (1)
    rheumatoid arthritis 1.86 1 14989715 (1)
    lymphoma 0 2 9576009 (1), 1384316 (1)

    Genetic Association Database (GAD): CD72
    Human Genome Epidemiology (HuGE) Navigator: CD72 (6 documents)

    Export disorders for CD72 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CD72 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with CD72)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B. (PubMed id 15459183)1, 4, 9 Hitomi Y.... Tokunaga K. (Hum. Mol. Genet. 2004)
    2. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PubMed id 1711157)1, 3, 9 van de Velde H.... Thielemans K. (Nature 1991)
    3. Identity of human Lyb-2 and CD72 and localization of the gene to chromosome 9. (PubMed id 2044654)1, 3, 9 Von Hoegen I....Parnes J.R. (Eur. J. Immunol. 1991)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. CD72 polymorphism associated with child-onset of idiopathic thrombocytopenic purpura in Chinese patients. (PubMed id 18071878)1, 4 Xu J....Yang R. (J. Clin. Immunol. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification of a human protein homologous to the mouse Lyb-2 B cell differentiation antigen and sequence of the corresponding cDNA. (PubMed id 2141045)1, 2 von Hoegen I.... Parnes J.R. (J. Immunol. 1990)
    8. Increased mutations of CD72 transcript in B-lymphocytes from adolescent patients with systemic lupus erythematosus. (PubMed id 17121583)1, 9 Kaneko U....Uchiyama M. (Pediatr Allergy Immunol 2006)
    9. CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72. (PubMed id 17786190)1, 9 Mizrahi S....Mandelboim O. (PLoS ONE 2007)
    10. Native soluble CD5 delivers a costimulatory signal to resting human B lymphocytes. (PubMed id 8806810)1, 9 Van de Velde H. and Thielemans K. (Cell. Immunol. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 971 HGNC: 1696 AceView: CD72 Ensembl:ENSG00000137101 euGenes: HUgn971
    ECgene: CD72 Kegg: 971 H-InvDB: CD72

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CD72 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD72 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_237

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CD72 gene:
    Search GeneIP for patents involving CD72

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CD72 (CD72)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for CD72 (CD72)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CD72   OriGene RNAi products in human, mouse, rat for CD72  
     OriGene qPCR primer pairs and template standards for CD72   OriGene Protein Over-expression Lysate for CD72  
     OriGene MassSpec for CD72   OriGene clones in human, mouse for CD72  
     OriGene qSTAR qPCR primer pairs in human, mouse for CD72   OriGene Purified Protein for CD72  
     OriGene ORF clones in mouse, rat for CD72   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD72   OriGene Custom Protein Services for CD72  

     
     
     Block miRNA regulation of human, mouse, rat CD72 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CD72
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD72 Predesigned siRNA for gene silencing in human, mouse, rat CD72
     QuantiFast Probe-based Assays in human, mouse, rat CD72 QuantiTect SYBR Green Assays in human, mouse, rat CD72
     PCR Arrays including human, mouse, rat CD72 Search Chromatin IP Primers for CD72
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD72  GeneGlobe Interaction Network for CD72
     Regulatory tfbs in CD72 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CD72 GenScript cDNA clones with any tag delivered in your preferred vector for CD72
     GenScript Custom Assay Services for CD72 GenScript Custom overexpressing Cell Line Services for CD72
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CD72
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CD72
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CD72 antibodies
     CD72 proteins
     CD72 lysates
     Antibodies for CD72
     See all of Abcam's Antibodies, Kits and Proteins for CD72
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CD72
     Proteins for CD72
     Antibodies for CD72
     ELISAs for CD72
     CLIAs for CD72



     Browse ESI BIO Cell Lines and PureStem Progenitors for CD72
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD72
     SwitchGear 3'UTR luciferase reporter plasmids for CD72
     SwitchGear Promoter luciferase reporter plasmids for CD72
     ThermoFisher Antibodies for CD72
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD72
     Browse compounds at ApexBio
     Search Addgene for plasmids for CD72
      Search eBioscience for proteins for CD72
      Search eBioscience for elisas for CD72
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CD72
     antibodies-online antibodies for CD72 (105 products)
     antibodies-online kits for CD72 (6 products)
     antibodies-online peptides for CD72
     antibodies-online proteins for CD72 (23 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CD72 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4