Aliases for CD70 Gene
Aliases for CD70 Gene
External Ids for CD70 Gene
- HGNC: 11937
- Entrez Gene: 970
- Ensembl: ENSG00000125726
- OMIM: 602840
- UniProtKB: P32970
Previous HGNC Symbols for CD70 Gene
- CD27LG
- TNFSF7
Previous GeneCards Identifiers for CD70 Gene
- GC19M006537
- GC19M006538
- GC19M006346
Summaries for CD70 Gene
-
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD70 Gene
CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Acute Myocarditis and Lymphoproliferative Syndrome 2. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and protease binding.
UniProtKB/Swiss-Prot for CD70 Gene
-
Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD70 Gene
Genomics for CD70 Gene
GeneHancer (GH) Regulatory Elements for CD70 Gene
Promoters and enhancers for CD70 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CD70 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CD70 gene promoter:
Regulatory Element Products
Genomic Locations for CD70 Gene
Genomic Locations for CD70 Gene
- chr19:6,583,183-6,604,103
- (GRCh38/hg38)
- Size:
- 20,921 bases
- Orientation:
- Minus strand
- chr19:6,583,194-6,604,114
- (GRCh37/hg19)
Genomic View for CD70 Gene
Genes around CD70 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC
CD70 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD70 Gene
Proteins for CD70 Gene
-
Protein details for CD70 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P32970-CD70_HUMAN
- Recommended name:
- CD70 antigen
- Protein Accession:
- P32970
- B4DPR8
- Q53XX4
- Q96J57
Protein attributes for CD70 Gene
- Size:
- 193 amino acids
- Molecular mass:
- 21118 Da
- Quaternary structure:
-
- Homotrimer.
Protein Expression for CD70 Gene
Post-translational modifications for CD70 Gene
- Glycosylation at posLast=6363, Tyr74, and posLast=170170
Other Protein References for CD70 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD70 (CD27 Ligand/TNFSF7)
-
Custom Antibody ServicesOriGene Antibodies for CD70
- Novus Biologicals Antibodies for CD70
-
Abcam antibodies for CD70
-
Cloud-Clone Corp. Antibodies for CD70
- Invitrogen Antibodies for CD70
- GeneTex CD70 antibody for CD70
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD70
- Sino Biological Antibodies for CD70
Protein Products
- R&D Systems Proteins and Enzymes for CD70 (CD27 Ligand/TNFSF7)
-
OriGene Purified Proteins for CD70
- Search Origene for MassSpec and Protein Over-expression Lysates for CD70
- Origene Custom Protein Services for CD70
- Sino Biological Cell Lysates for CD70
- Sino Biological Recombinant Proteins for CD70
- ProSpec Recombinant Proteins for CD70
-
Cloud-Clone Corp. Proteins for CD70
- GeneTex Proteins for CD70
-
ProSci Proteins for CD70
-
Abcam proteins for CD70
Assay Products
-
Cloud-Clone Corp. Assay Kits for CD70
-
Abcam assays for CD70
No data available for DME Specific Peptides for CD70 Gene
Domains & Families for CD70 Gene
Gene Families for CD70 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CD70 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD70 Gene
Graphical View of Domain Structure for InterPro Entry
P32970- Family:
-
- Belongs to the tumor necrosis factor family.
Function for CD70 Gene
Molecular function for CD70 Gene
- UniProtKB/Swiss-Prot Function:
- Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 12777399 |
| GO:0005102 | receptor binding | TAS | 8120384 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005164 | tumor necrosis factor receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 12324477 |
Phenotypes for CD70 Gene
- MGI mutant phenotypes for CD70:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CD70:
Animal Models for CD70 Gene
- MGI Knock Outs for CD70:
-
- Cd70 tm1.1Jda
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD70
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CD70 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD70 gene
- Search ViGene Biosciences for CD70
CRISPR Products
-
OriGene CRISPR knockouts for CD70
- genomics-online: gRNA clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- Applied Biological Materials CRISPR for CD70
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD70
- GenScript: Design CRISPR guide RNA sequences for CD70
miRNA for CD70 Gene
- miRTarBase miRNAs that target CD70
miRNA Products
- Search ViGene Biosciences for CD70
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CD70
- Browse OriGene Inhibitory RNA Products For CD70
- genomics-online: shRNA clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
-
ViGene Biosciences ready-to-package AAV shRNAs for CD70 gene
Clone Products
- Sino Biological Human cDNA Clone for CD70
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD70
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD70
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD70
- genomics-online: cdna clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- orf clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- Applied Biological Materials Clones for CD70
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD70 (CD27 Ligand/TNFSF7)
Cell Line Products
-
Horizon Cell Lines for CD70
-
ViGene Biosciences adenoviral particle packaged cDNA for CD70 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD70 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD70 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD70 Gene
Localization for CD70 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD70 Gene
- Membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 2 |
| lysosome | 1 |
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8120384 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for CD70 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
.47
|
|
| 2 | ERK Signaling |
.61
|
|
| 3 | Akt Signaling |
.60
|
.60
|
| 4 | PAK Pathway |
.56
|
|
| 5 | T Cell Co-Signaling Pathway: Ligand-Receptor Interactions | ||
Pathways by source for CD70 Gene
4 Reactome pathways for CD70 Gene
1 KEGG pathway for CD70 Gene
1 GeneGo (Thomson Reuters) pathway for CD70 Gene
1 R&D Systems pathway for CD70 Gene
17 Qiagen pathways for CD70 Gene
Interacting Proteins for CD70 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8387892 |
| GO:0007267 | cell-cell signaling | TAS | 8387892 |
| GO:0008283 | cell proliferation | TAS | 8120384 |
| GO:0010469 | regulation of receptor activity | IEA | -- |
Transcripts for CD70 Gene
mRNA/cDNA for CD70 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (44) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CD70 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CD70
- genomics-online: gRNA clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- Applied Biological Materials CRISPR for CD70
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD70
- GenScript: Design CRISPR guide RNA sequences for CD70
miRNA Products
- Search ViGene Biosciences for CD70
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CD70
- Browse OriGene Inhibitory RNA Products For CD70
- genomics-online: shRNA clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
-
ViGene Biosciences ready-to-package AAV shRNAs for CD70 gene
Clone Products
- Sino Biological Human cDNA Clone for CD70
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD70
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD70
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD70
- genomics-online: cdna clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- orf clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- Applied Biological Materials Clones for CD70
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD70 (CD27 Ligand/TNFSF7)
Expression for CD70 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Neural Crest (Gastrulation Derivatives)
- Blood (Hematopoietic System)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Kidney (Urinary System)
This gene is overexpressed in Liver (68.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD70 Gene
NURSA nuclear receptor signaling pathways regulating expression of CD70 Gene:
CD70SOURCE GeneReport for Unigene cluster for CD70 Gene:
Hs.501497Evidence on tissue expression from TISSUES for CD70 Gene
- Kidney(4.2)
- Blood(3.2)
- Lymph node(2.2)
- Spleen(2)
Primer Products
-
OriGene qPCR primer pairs for CD70
-
OriGene qPCR primer pairs and template standards for CD70
- genomics-online: primer clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD70 Gene
Orthologs for CD70 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | CD70 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CD70 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cd70 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd70 33 16 34 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | CD70 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CD70 34 |
|
OneToOne |
- Species where no ortholog for CD70 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CD70 Gene
No data available for Paralogs for CD70 Gene
Variants for CD70 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000117334 | -- | 6,585,301(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000189840 | -- | 6,581,438(-) | C/T | downstream_transcript_variant | |
| rs1000340785 | -- | 6,587,814(-) | A/G | intron_variant | |
| rs1000350920 | -- | 6,587,561(-) | T/C | intron_variant | |
| rs1000446032 | -- | 6,592,423(-) | G/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.78;
33.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CD70 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD70 Gene
Disorders for CD70 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute myocarditis |
|
|
| lymphoproliferative syndrome 2 |
|
|
| macroglobulinemia |
|
|
| corneal dystrophy, congenital stromal |
|
|
| leukemia, chronic lymphocytic |
|
Search CD70 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CD70
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CD70 Gene
Publications for CD70 Gene
- The cloning of CD70 and its identification as the ligand for CD27. (PMID: 8120384) Bowman MR … Herrmann S (Journal of immunology (Baltimore, Md. : 1950) 1994) 2 3 4 58
- Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. (PMID: 8387892) Goodwin RG … Hennen K (Cell 1993) 2 3 4 58
- Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70. (PMID: 20139096) Shaw J … Liu YJ (Blood 2010) 3 22 58
- Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee KM … Lan Q (American journal of hematology 2010) 3 44 58
- Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
Products for CD70 Gene
- R&D Systems Antibodies for CD70 (CD27 Ligand/TNFSF7)
- R&D Systems Proteins and Enzymes for CD70 (CD27 Ligand/TNFSF7)
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for CD70 (CD27 Ligand/TNFSF7)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CD70
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CD70
- Search Origene for MassSpec and Protein Over-expression Lysates for CD70
- Origene Custom Protein Services for CD70
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD70
- Browse OriGene Inhibitory RNA Products For CD70
- OriGene qPCR primer pairs and template standards for CD70
- OriGene qPCR primer pairs for CD70
- OriGene CRISPR knockouts for CD70
- OriGene ORF clones in human for CD70
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD70
- GenScript: Next-day shipping of latest version cDNA ORF clones for CD70 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CD70
- GenScript Custom Assay Services for CD70
- GenScript Custom overexpressing Cell Line Services for CD70
- GenScript: Design CRISPR guide RNA sequences for CD70
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD70
- Sino Biological Human cDNA Clone for CD70
- Sino Biological Cell Lysates for CD70
- Sino Biological Recombinant Proteins for CD70
- Sino Biological Antibodies for CD70
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CD70
- Novus Biologicals lysates and proteins for CD70
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CD70
- Abcam proteins for CD70
- Abcam assays for CD70
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CD70
- Cloud-Clone Corp. Antibodies for CD70
- Cloud-Clone Corp. Proteins for CD70
- Cloud-Clone Corp. Assay Kits for CD70
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CD70
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD70
- VectorBuilder custom plasmid, inducible vectors for CD70
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD70
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD70
- antibodies-online: Search results for 187 available CD70 Antibodies ranked by validation data
- Compare Top CD70 Antibodies
- antibodies-online: Search results for 15 available CD70 Elisa Kits ranked by validation data
- Compare Top CD70 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 33 available CD70 Proteins ranked by validation data
- Compare Top CD70 Proteins
- GeneTex CD70 antibody for CD70
- GeneTex Proteins for CD70
- ViGene Biosciences adenoviral particle packaged cDNA for CD70 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD70 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD70 gene
- Search ViGene Biosciences for CD70
- Santa Cruz Biotechnology (SCBT) Antibodies for CD70
- Search Santa Cruz Biotechnology (SCBT) for CD70 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD70
- Horizon Cell Lines for CD70
- genomics-online: cdna clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- orf clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- genomics-online: gRNA clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- genomics-online: primer clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- genomics-online: shRNA clones - Search results for 132 available CD70 gene related products
- Overview of 132 available CD70 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pCMV6-XL5
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
Sources for CD70 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew