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Aliases for CD70 Gene

Aliases for CD70 Gene

  • CD70 Molecule 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 7 2 3
  • Tumor Necrosis Factor Ligand Superfamily Member 7 3 4
  • CD27 Ligand 3 4
  • CD27LG 3 4
  • TNFSF7 3 4
  • CD27-L 3 4
  • CD27L 3 4
  • Tumor Necrosis Factor Ligand 8A 3
  • Surface Antigen CD70 3
  • Ki-24 Antigen 3
  • CD70 Antigen 4
  • TNLG8A 3

External Ids for CD70 Gene

Previous HGNC Symbols for CD70 Gene

  • CD27LG
  • TNFSF7

Previous GeneCards Identifiers for CD70 Gene

  • GC19M006537
  • GC19M006538
  • GC19M006346

Summaries for CD70 Gene

Entrez Gene Summary for CD70 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD70 Gene

CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include chronic lymphocytic leukemia and subacute cutaneous lupus erythematosus. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor binding and protease binding.

UniProtKB/Swiss-Prot for CD70 Gene

  • Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD70 Gene

Genomics for CD70 Gene

Regulatory Elements for CD70 Gene

Promoters for CD70 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD70 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD70 Gene

Chromosome:
19
Start:
6,583,183 bp from pter
End:
6,604,103 bp from pter
Size:
20,921 bases
Orientation:
Minus strand

Genomic View for CD70 Gene

Genes around CD70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD70 Gene

Proteins for CD70 Gene

  • Protein details for CD70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32970-CD70_HUMAN
    Recommended name:
    CD70 antigen
    Protein Accession:
    P32970
    Secondary Accessions:
    • B4DPR8
    • Q53XX4
    • Q96J57

    Protein attributes for CD70 Gene

    Size:
    193 amino acids
    Molecular mass:
    21118 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for CD70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD70 Gene

Proteomics data for CD70 Gene at MOPED

Post-translational modifications for CD70 Gene

  • Glycosylation at Asn 63, Tyr 74, and Asn 170
  • Modification sites at PhosphoSitePlus

Other Protein References for CD70 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CD70 (CD27 Ligand/TNFSF7)

No data available for DME Specific Peptides for CD70 Gene

Domains & Families for CD70 Gene

Protein Domains for CD70 Gene

Graphical View of Domain Structure for InterPro Entry

P32970

UniProtKB/Swiss-Prot:

CD70_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with CD70: view

Function for CD70 Gene

Molecular function for CD70 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Gene Ontology (GO) - Molecular Function for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IEA,IPI 12324477
genes like me logo Genes that share ontologies with CD70: view
genes like me logo Genes that share phenotypes with CD70: view

Animal Models for CD70 Gene

MGI Knock Outs for CD70:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD70

miRNA for CD70 Gene

miRTarBase miRNAs that target CD70

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD70 Gene

Localization for CD70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD70 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD70 Gene COMPARTMENTS Subcellular localization image for CD70 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD70: view

Pathways & Interactions for CD70 Gene

genes like me logo Genes that share pathways with CD70: view

Interacting Proteins for CD70 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000245903%0d%0a9606.ENSP00000266557%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: P32970-CD70_HUMAN ENSP00000245903 for CD70 Gene via I2D STRING

SIGNOR curated interactions for CD70 Gene

Activates:

Gene Ontology (GO) - Biological Process for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 8387892
genes like me logo Genes that share ontologies with CD70: view

Drugs & Compounds for CD70 Gene

(6) Drugs for CD70 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MDX-1203 Pharma 0
MDX-1411 Pharma 0
SGN-70 Pharma antibody 0
SGN-75 Pharma antibody 0

(2) Additional Compounds for CD70 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD70: view

Transcripts for CD70 Gene

mRNA/cDNA for CD70 Gene

Unigene Clusters for CD70 Gene

CD70 molecule:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD70 Gene

No ASD Table

Relevant External Links for CD70 Gene

GeneLoc Exon Structure for
CD70
ECgene alternative splicing isoforms for
CD70

Expression for CD70 Gene

mRNA expression in normal human tissues for CD70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD70 Gene

This gene is overexpressed in Liver (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD70 Gene



SOURCE GeneReport for Unigene cluster for CD70 Gene Hs.501497

genes like me logo Genes that share expression patterns with CD70: view

Protein tissue co-expression partners for CD70 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CD70 Gene

Orthologs for CD70 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD70 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD70 35
  • 72.87 (n)
  • 65.96 (a)
CD70 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD70 35
  • 77.37 (n)
  • 70.53 (a)
CD70 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd70 35
  • 64.25 (n)
  • 56.99 (a)
Cd70 16
Cd70 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd70 35
  • 64.59 (n)
  • 55.44 (a)
oppossum
(Monodelphis domestica)
Mammalia CD70 36
  • 35 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD70 36
  • 64 (a)
OneToOne
Species with no ortholog for CD70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD70 Gene

ENSEMBL:
Gene Tree for CD70 (if available)
TreeFam:
Gene Tree for CD70 (if available)

Paralogs for CD70 Gene

No data available for Paralogs for CD70 Gene

Variants for CD70 Gene

Sequence variations from dbSNP and Humsavar for CD70 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs452824 -- 6,589,999(+) tctgt(C/G)tgtgt intron-variant
rs453462 -- 6,585,910(+) ACTAC(C/G)CCCCA utr-variant-3-prime
rs171093 -- 6,589,415(+) gacag(A/G)atctc intron-variant
rs191499 -- 6,587,075(+) gagag(A/C)gagag intron-variant
rs344586 -- 6,588,220(+) tgtca(C/G)acact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD70 Gene

Variant ID Type Subtype PubMed ID
nsv833728 CNV Loss 17160897

Variation tolerance for CD70 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD70 Gene

HapMap Linkage Disequilibrium report
CD70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD70 Gene

Disorders for CD70 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CD70 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • cll
subacute cutaneous lupus erythematosus
  • lupus erythematosus, subacute cutaneous
common variable immunodeficiency
  • acquired agammaglobulinemia
corneal dystrophy, congenital stromal
  • congenital stromal corneal dystrophy
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CD70 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD70

Genetic Association Database (GAD)
CD70
Human Genome Epidemiology (HuGE) Navigator
CD70
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD70
genes like me logo Genes that share disorders with CD70: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD70 Gene

Publications for CD70 Gene

  1. The cloning of CD70 and its identification as the ligand for CD27. (PMID: 8120384) Bowman M.R. … Herrmann S. (J. Immunol. 1994) 2 3 4 67
  2. Fyn and CD70 expression in CD4+ T cells from patients with systemic lupus erythematosus. (PMID: 19955046) Kozlowska A. … Jagodzinski P.P. (J. Rheumatol. 2010) 3 23
  3. Epigenetic silencing of TNFSF7 (CD70) by DNA methylation during progression to breast cancer. (PMID: 20119871) Yu S.E. … Jang Y.K. (Mol. Cells 2010) 3 23
  4. Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70. (PMID: 20139096) Shaw J. … Liu Y.J. (Blood 2010) 3 23
  5. Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation. (PMID: 20201989) Arimoto-Miyamoto K. … Uchiyama T. (Immunology 2010) 3 23

Products for CD70 Gene

Sources for CD70 Gene

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