CD70 Gene

Aliases
for CD70 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC19M006537 GC19M006538 GC19M006346

Summaries
for CD70 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CD70 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9  NC_018930.2  NT_011295.12  

SwitchGear Promoter luciferase reporter plasmid: CD70 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD70

CD70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006583:  view genomic region     (about GC identifiers)

Proteins
for CD70 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CD70: NX_P32970

Explore proteomics data for CD70 at MOPED

Post-translational modifications: 

CD70 Human Recombinant Protein Products:

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	Novus Biologicals CD70 Proteins Novus Biologicals CD70 Lysates
	Sino Biological Recombinant Protein for CD70 Sino Biological Cell Lysate for CD70
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CD70
	Search GeneTex for Proteins for CD70
	antibodies-online proteins for CD70 (17 products)
	antibodies-online peptides for CD70

CD70 Antibody Products:

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	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CD70
	antibodies-online antibodies for CD70 (127 products)

CD70 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CD70
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	GenScript Custom Assay Services for CD70
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CD70
	antibodies-online kits for CD70 (10 products)

Domains /
Families
for CD70 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P32970

Find genes that share domains with CD70           About GenesLikeMe

Function
for CD70 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 5 molecular function terms:    About this table

(inferred from 2 alleles) (MGI details for Cd70)

genOway: Develop your customized and physiologically relevant rodent model for CD70

miRNA Products:		Block miRNA regulation of human, mouse, rat CD70 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate CD70
		SwitchGear 3'UTR luciferase reporter plasmid: CD70 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CD70
		Predesigned siRNA for gene silencing in human, mouse, rat CD70

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD70

Clone Products:		OriGene clones in human, mouse for CD70 (see all 6) OriGene ORF clones in mouse, rat for CD70 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD70 (NM_001252)
		Sino Biological Human cDNA Clone for CD70
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD70
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD70

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD70
		Browse ESI BIO Cell Lines and PureStem Progenitors for CD70

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD70

Localization
for CD70 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	4
extracellular	3

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Gene Ontology (GO): 5 cellular component terms:    About this table

Pathways & Interactions
for CD70 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CD70 About     See pathways by source

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	SuperPath	Contained pathways About
1	TNF Signaling	TNF Signaling 0.50 TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions 0.49 Death Receptor Signaling 0.50 NF-kB (NFkB) Pathway 0.46
2	PEDF Induced Signaling	Cytokine-cytokine receptor interaction 0.43
3	Apoptosis Signaling Pathways	Apoptosis and survival Apoptotic TNF-family pathways 0.35

1 R&D Systems Pathway for CD70

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD70

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Rho Family GTPases
	MIF Mediated Glucocorticoid Regulation

1 GeneGo (Thomson Reuters) Pathway for CD70

Apoptosis and survival Apoptotic TNF-family pathways

3 Sino Biological Pathways for CD70

	TNF Signaling
	Death Receptor Signaling
	NF-kB (NFkB) Pathway

1 Kegg Pathway  (Kegg details for CD70)

Cytokine-cytokine receptor interaction

Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for CD70 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CD70 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CD70 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CD70 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTACACATCC

About this image

Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
Muscle Progenitor Cells Mandibular Arch Muscles
Neural Crest (Gastrulation Derivatives)
PureStem 4D20.8, NCr-fac Progenitor
Bone (Muscoskeletal System)
HyStem+TGFbeta3+GDF5-induced SM30 cells
Blood (Hematopoietic System)
Tumor infiltrating lymphocytes (C?ntego)
Cartilage (Muscoskeletal System)
HyStem+TGFbeta3+GDF5-induced SM30 cells

Primer Products:		OriGene qPCR primer pairs and template standards for CD70 OriGene qSTAR qPCR primer pairs in human, mouse for CD70
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD70
		QuantiTect SYBR Green Assays in human, mouse, rat CD70
		QuantiFast Probe-based Assays in human, mouse, rat CD70

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD70

Orthologs
for CD70 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CD70 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for CD70 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CD70 (see all 206)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs2015935971,2	C	--	6585359(+)	AGAAC-/TTTTTTT	1	--	ds5001		0	--	--	--	--
rs30555331,2	C	--	6585374(+)	TTTTT-/TT/TTT         GACAA	2	--	ds5001 cds1		1		NA	2
rs4325601,2	C,F,A	--	6585378(+)	tttgaT/Caagga	1	--	ds5001		7		NA CSA WA EA	366
rs81105811,2	C,F,H	--	6585650(+)	gcccaG/AccCAC	1	--	ds5001		9		NS EA NA	752
rs1452685921,2		--	6585746(+)	AGTGGC/TGCAAT	1	--	ds5001		0	--	--	--	--
rs81116151,2	C	--	6585788(+)	tcaagA/Cgattc	1	--	ds5001		0	--	--	--	--
rs1857100081,2		--	6585840(+)	GCCACA/GAAGCC	1	--	ds5001		0	--	--	--	--
rs4270031,2	C,F,A	--	6585842(+)	CACGAA/CGCCCA	1	--	ds5001		8		NA CSA WA EA	368
rs4534621,2	C	--	6585921(+)	ACTACC/GCCCCA	1	--	ut31 ese3		8		MN NA WA CSA	197
rs729825181,2		--	6586005(+)	AAATTA/TAAAAA	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD70 (6583194 - 6604114 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CD70:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv833728	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CD70

DNA2.0 Custom Variant and Variant Library Synthesis for CD70

Disorders / Diseases
for CD70 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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6 diseases for CD70

Selected Novoseek inferred disease relationships for CD70 gene (see all 21)    About this table

Publications
for CD70 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CD70 gene, integrated from 10 sources (see all 168): (articles sorted by number of sources associating them with CD70)

Utopia: connect your pdf to the dynamic world of online information

1. The cloning of CD70 and its identification as the ligand for CD27. (PubMed id 8120384)^{1, 2, 3} Bowman M.R....Herrmann S. (J. Immunol. 1994)
2. Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. (PubMed id 8387892)^{1, 2, 3} Goodwin R.G.... Beckmann M.P. (Cell 1993)
3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (PLoS Genet. 2010)
4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (Am. J. Hematol. 2010)
5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)^{1, 4} Hosgood H.D....Lan Q. (Occup Environ Med 2009)
6. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)^{1, 4} Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
7. Investigation of the NOTCH3 and TNFSF7 genes on C19p13 as candidates for migraine. (PubMed id 19018300)^{1, 4} Smith R.A....Griffiths L. (Open Neurol J 2008)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
9. Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation. (PubMed id 20201989)^{1, 9} Arimoto-Miyamoto K....Uchiyama T. (Immunology 2010)
10. CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. (PubMed id 16892042)^{1, 9} Adam P.J....Harris A.L. (Br. J. Cancer 2006)

External Searches for CD70 gene

Genome Databases showing CD70 gene

Other Databases showing CD70 gene

Specialized Databases showing CD70 gene

Products
for CD70 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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