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CD70 Gene

protein-coding GIFtS: 58
GCID: GC19M006583

CD70 Molecule

(Previous names: tumor necrosis factor (ligand) superfamily, member 7)
(Previous symbols: CD27LG, TNFSF7)

See CD70-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
CD70 Molecule¹ ²		CD27-L² ³
TNFSF7¹ ² ³ ⁵		CD27 Ligand² ³
CD27LG¹ ² ³		CD70 Antigen² ³
CD27L² ³ ⁵		Ki-24 Antigen²
Tumor Necrosis Factor (Ligand) Superfamily, Member 7¹ ²		Surface Antigen CD70²
Tumor Necrosis Factor Ligand Superfamily Member 7² ³

External Ids:	HGNC: 11937¹	Entrez Gene: 970²	Ensembl: ENSG00000125726⁷	OMIM: 602840⁵	UniProtKB: P32970³

Export aliases for CD70 gene to outside databases

Previous GC identifers: GC19M006537 GC19M006538 GC19M006346

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD70 Gene:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This

cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B

lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and

contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation,

cytotoxic function of natural killer cells, and immunoglobulin sythesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD70 Gene:

CD70 (CD70 molecule) is a protein-coding gene. Diseases associated with CD70 include mantle cell lymphoma, and non-hodgkin lymphoma. GO annotations related to this gene include protease binding and receptor binding.

UniProtKB/Swiss-Prot: CD70_HUMAN, P32970

Function: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of

costimulated T-cells and enhances the generation of cytolytic T-cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9 NC_018930.2 NT_011295.12

Regulatory elements:

Regulatory transcription factor binding sites in the CD70 gene promoter:
AP-1 ATF-2 c-Jun NF-kappaB1 NF-kappaB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD70 promoter sequence

Search Chromatin IP Primers for CD70

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD70

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13

CD70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD70 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M006583: view genomic region (about GC identifiers)

Start:	6,583,194 bp from pter	End:	6,604,114 bp from pter
Size:	20,921 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CD70_HUMAN, P32970 (See protein sequence)

Recommended Name: CD70 antigen

Size: 193 amino acids; 21118 Da

Subunit: Homotrimer (Probable)

Secondary accessions: Q53XX4 Q96J57

Explore the universe of human proteins at neXtProt for CD70: NX_P32970

Explore proteomics data for CD70 at MOPED

Post-translational modifications:

Glycosylation² at Asn63, Tyr74, Asn170

Modification sites at PhosphoSitePlus

See CD70 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001243.1

ENSEMBL proteins:

ENSP00000395294 ENSP00000245903 ENSP00000470805

CD70 Human Recombinant Protein Products:

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	Enzo Life Sciences proteins for CD70
	OriGene Purified Protein for CD70 OriGene Protein Over-expression Lysate for CD70 OriGene MassSpec for CD70 OriGene Custom Protein Services for CD70
	GenScript Custom Purified and Recombinant Proteins Services for CD70
	Novus Biologicals CD70 Proteins Novus Biologicals CD70 Lysates
	Sino Biological Recombinant Protein for CD70 Sino Biological Cell Lysate for CD70
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CD70
	antibodies-online proteins for CD70 (17 products)
	antibodies-online peptides for CD70

CD70 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD70 (CD27 Ligand/TNFSF7)
	OriGene Antibodies for CD70 OriGene Custom Antibody Services for CD70
	Novus Biologicals CD70 Antibodies
	Abcam antibodies for CD70
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CD70
	antibodies-online antibodies for CD70 (127 products)

CD70 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CD70
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD70
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CD70
	antibodies-online kits for CD70 (10 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CD: CD molecules

TNFSF: Tumor necrosis factor (ligand) superfamily

3 InterPro protein domains:

IPR021184 TNF_CS

IPR006052 TNF_dom

IPR008983 Tumour_necrosis_fac-like_dom

Graphical View of Domain Structure for InterPro Entry P32970

ProtoNet protein and cluster: P32970

UniProtKB/Swiss-Prot: CD70_HUMAN, P32970

Similarity: Belongs to the tumor necrosis factor family

Find genes that share domains with CD70 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CD70_HUMAN, P32970

Function: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of

costimulated T-cells and enhances the generation of cytolytic T-cells

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	12777399
GO:0005102	receptor binding	TAS	8120384
GO:0005125	cytokine activity	IEA	--
GO:0005164	tumor necrosis factor receptor binding	IEA	--
GO:0005515	protein binding	IPI	12324477

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Phenotypes:
1 GenomeRNAi human phenotype for CD70:

Decreased viability

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd70):

hematopoietic system

immune system

Find genes that share phenotypes with CD70 About GenesLikeMe

Animal Models:
MGI mouse knock-out Cd70^tm1.1Jda for CD70

genOway: Develop your customized and physiologically relevant rodent model for CD70

miRNA Products:		Block miRNA regulation of human, mouse, rat CD70 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate CD70
		SwitchGear 3'UTR luciferase reporter plasmid: CD70 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CD70
		Predesigned siRNA for gene silencing in human, mouse, rat CD70

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD70

Clone Products:		OriGene clones in human, mouse for CD70 (see all 6) OriGene ORF clones in mouse, rat for CD70 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD70 (NM_001252)
		Sino Biological Human cDNA Clone for CD70
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD70
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD70

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD70
		Browse ESI BIO Cell Lines and PureStem Progenitors for CD70

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD70

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CD70_HUMAN, P32970: Membrane; Single-pass type II membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
extracellular	3

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005886	plasma membrane	IDA	11920585
GO:0005887	integral component of plasma membrane	TAS	8120384
GO:0016020	membrane	--	--
GO:0070062	extracellular vesicular exosome	IDA	--

Find genes that share ontologies with CD70 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CD70 About

See pathways by source

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SuperPath

Contained pathways About

TNF Signaling

	TNF Signaling	0.50			TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions	0.49
	Death Receptor Signaling	0.50			NF-kB (NFkB) Pathway	0.46

PEDF Induced Signaling

Cytokine-cytokine receptor interaction

0.43

Apoptosis Signaling Pathways

Apoptosis and survival Apoptotic TNF-family pathways

0.35

Find genes that share SuperPaths with CD70 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for CD70

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD70 (see all 17)

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	Rho Family GTPases
	MIF Mediated Glucocorticoid Regulation

1 GeneGo (Thomson Reuters) Pathway for CD70

Apoptosis and survival Apoptotic TNF-family pathways

3 Sino Biological Pathways for CD70

	TNF Signaling
	Death Receptor Signaling
	NF-kB (NFkB) Pathway

1 Kegg Pathway (Kegg details for CD70):

Cytokine-cytokine receptor interaction

Pathway & Disease-focused RT² Profiler PCR Arrays including CD70 (see all 9):

Cell Surface Markers in human mouse rat

Apoptosis in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Type I Interferon Response in human mouse rat

Common Cytokines in human mouse rat

Interactions:

GeneGlobe Interaction Network for CD70

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for CD70 (P32970³ ENSP00000245903⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD27	P26842³, ENSP00000266557⁴	I2D: score=2 STRING: ENSP00000266557
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	IEA	--
GO:0007165	signal transduction	TAS	8387892
GO:0007267	cell-cell signaling	TAS	8387892
GO:0008283	cell proliferation	TAS	8120384
GO:0097191	extrinsic apoptotic signaling pathway	IDA	9177220

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CD70

4 Novoseek inferred chemical compound relationships for CD70 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hydralazine	42.4	9	15879118 (2), 15188362 (1), 17911642 (1)
procainamide	39.8	4	15879118 (2), 15188362 (1)
rantes	27.8	2	14742640 (1), 12212969 (1)
ionomycin	15.1	1	9143940 (1)

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CD70 gene:

NM_001252.4

Unigene Cluster for CD70:

CD70 molecule

Hs.501497 [show with all ESTs]

Unigene Representative Sequence: BM464627

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000423145(uc010xjf.1) ENST00000245903(uc002mfi.3) ENST00000597430

miRNA Products:		Block miRNA regulation of human, mouse, rat CD70 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate CD70
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Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CD70
		Predesigned siRNA for gene silencing in human, mouse, rat CD70

Clone Products:		OriGene clones in human, mouse for CD70 (see all 6) OriGene ORF clones in mouse, rat for CD70 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD70 (NM_001252)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD70
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD70

Primer Products:		OriGene qPCR primer pairs and template standards for CD70 OriGene qSTAR qPCR primer pairs in human, mouse for CD70
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CD70
		QuantiTect SYBR Green Assays in human, mouse, rat CD70
		QuantiFast Probe-based Assays in human, mouse, rat CD70

Additional mRNA sequence:

BC000725.2 BT007211.1 L08096.1 S69339.1

4 DOTS entries:

DT.203123 DT.99973779 DT.100738158 DT.121468668

Selected AceView cDNA sequences (see all 44):

BE273639 CR626341 BM464627 BQ933186 BU540451 BQ049765 BM477559 BM852184

NM_001252 BG751344 BT007211 L08096 AL560676 BG775537 BM046816 BC000725

BQ677350 BG421005 BG170786 BG752420 BM850868 BQ944266 BU540977 BE908993

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CD70 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTACACATCC

About this image

CD70 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Muscle Progenitor Cells Mandibular Arch Muscles

Neural Crest (Gastrulation Derivatives)
PureStem 4D20.8, NCr-fac Progenitor

Bone (Muscoskeletal System)
HyStem+TGFbeta3+GDF5-induced SM30 cells

Blood (Hematopoietic System)
Tumor infiltrating lymphocytes (C?ntego)

Cartilage (Muscoskeletal System)
HyStem+TGFbeta3+GDF5-induced SM30 cells

CD70 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CD70 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.501497

Pathway & Disease-focused RT² Profiler PCR Arrays including CD70 (see all 9):

Cell Surface Markers in human mouse rat

Apoptosis in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Type I Interferon Response in human mouse rat

Common Cytokines in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CD70 OriGene qSTAR qPCR primer pairs in human, mouse for CD70
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CD70
		QuantiTect SYBR Green Assays in human, mouse, rat CD70
		QuantiFast Probe-based Assays in human, mouse, rat CD70

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD70

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for CD70 gene from Selected species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd70^{1 , 5}	CD70 antigen^{1, 5}	64.25(n)¹ 56.99(a)¹		17 (29.69 cM)⁵ 21948¹ NM_011617.2¹ NP_035747.1¹ 57145997⁵

ENSEMBL Gene Tree for CD70 (if available)
TreeFam Gene Tree for CD70 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201593597^1,2	C	--	6585359(+)	`AGAAC-/TTTTTTT`	1	--	ds500¹		0	--	--	--	--
rs3055533^1,2	C	--	6585374(+)	`TTTTT-/TT/TTT GACAA`	2	--	ds500¹ cds¹		1		NA	2
rs432560^1,2	C,F,A	--	6585378(+)	`tttgaT/Caagga`	1	--	ds500¹		7		NA CSA WA EA	366
rs8110581^1,2	C,F,H	--	6585650(+)	`gcccaG/AccCAC`	1	--	ds500¹		9		NS EA NA	752
rs145268592^1,2		--	6585746(+)	`AGTGGC/TGCAAT`	1	--	ds500¹		0	--	--	--	--
rs8111615^1,2	C	--	6585788(+)	`tcaagA/Cgattc`	1	--	ds500¹		0	--	--	--	--
rs185710008^1,2		--	6585840(+)	`GCCACA/GAAGCC`	1	--	ds500¹		0	--	--	--	--
rs427003^1,2	C,F,A	--	6585842(+)	`CACGAA/CGCCCA`	1	--	ds500¹		8		NA CSA WA EA	368
rs453462^1,2	C	--	6585921(+)	`ACTACC/GCCCCA`	1	--	ut3¹ ese³		8		MN NA WA CSA	197
rs72982518^1,2		--	6586005(+)	`AAATTA/TAAAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD70 (6583194 - 6604114 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for CD70: About this table

Variant ID	Type	Subtype	PubMed ID
nsv833728	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CD70

DNA2.0 Custom Variant and Variant Library Synthesis for CD70

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602840 OMIM disorders: --

6 diseases for CD70:
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mantle cell lymphoma non-hodgkin lymphoma acute myocarditis subacute cutaneous lupus erythematosus

stomach cancer myocarditis

1 inferred disease relationship from the University of Copenhagen DISEASES database for CD70:

Lupus erythematosus

Find genes that share disorders with CD70 About GenesLikeMe

Selected Novoseek inferred disease relationships for CD70 gene (see all 21) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	50.4	23	11980654 (2), 16547002 (1), 19760069 (1), 12709024 (1) (see all 21)
leukemia b-cell	45.8	1	7540066 (1)
lymphocytic leukemia chronic b-cell	41.7	1	7540066 (1)
lupus erythematosus systemic	40.2	2	19955046 (1), 20223637 (1)
tumors	36.9	56	11228533 (5), 9622100 (5), 16217761 (3), 15879877 (3) (see all 29)
leukemia lymphocytic chronic	33	3	15356138 (1), 7540066 (1), 10221513 (1)
autoimmunity	30.8	2	20035856 (1)
carcinoma renal cell	29.2	4	17132225 (1), 15879877 (1), 16892042 (1)
lymphoma	24.7	4	15356138 (1), 16272354 (1), 19806404 (1), 10419648 (1)
glioblastoma	18.7	2	11980654 (1), 15958592 (1)

Genetic Association Database (GAD): CD70
Human Genome Epidemiology (HuGE) Navigator: CD70 (7 documents)

Export disorders for CD70 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CD70 gene, integrated from 10 sources (see all 168):
(articles sorted by number of sources associating them with CD70)

Utopia: connect your pdf to the dynamic
world of online information

The cloning of CD70 and its identification as the ligand for CD27. (PubMed id 8120384)^{1, 2, 3} Bowman M.R....Herrmann S. (J. Immunol. 1994)
Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. (PubMed id 8387892)^{1, 2, 3} Goodwin R.G.... Beckmann M.P. (Cell 1993)
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (PLoS Genet. 2010)
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (Am. J. Hematol. 2010)
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)^{1, 4} Hosgood H.D....Lan Q. (Occup Environ Med 2009)
Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)^{1, 4} Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
Investigation of the NOTCH3 and TNFSF7 genes on C19p13 as candidates for migraine. (PubMed id 19018300)^{1, 4} Smith R.A....Griffiths L. (Open Neurol J 2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation. (PubMed id 20201989)^{1, 9} Arimoto-Miyamoto K....Uchiyama T. (Immunology 2010)
CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. (PubMed id 16892042)^{1, 9} Adam P.J....Harris A.L. (Br. J. Cancer 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 970	HGNC: 11937	AceView: TNFSF7	Ensembl:ENSG00000125726	euGenes: HUgn970
ECgene: CD70	Kegg: 970	H-InvDB: CD70

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CD70	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CD70 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD70 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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