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Aliases for CD70 Gene

Aliases for CD70 Gene

  • CD70 Molecule 2 3
  • TNFSF7 3 4 6
  • CD27L 3 4 6
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 7 2 3
  • Tumor Necrosis Factor Ligand Superfamily Member 7 3 4
  • CD70 Antigen 3 4
  • CD27 Ligand 3 4
  • CD27LG 3 4
  • CD27-L 3 4
  • Surface Antigen CD70 3
  • Ki-24 Antigen 3

External Ids for CD70 Gene

Previous HGNC Symbols for CD70 Gene

  • CD27LG
  • TNFSF7

Previous GeneCards Identifiers for CD70 Gene

  • GC19M006537
  • GC19M006538
  • GC19M006346

Summaries for CD70 Gene

Entrez Gene Summary for CD70 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD70 Gene

CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include acute myocarditis and myocarditis. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor binding and protease binding.

UniProtKB/Swiss-Prot for CD70 Gene

  • Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD70 Gene

Genomics for CD70 Gene

Regulatory Elements for CD70 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD70 Gene

Start:
6,583,183 bp from pter
End:
6,604,103 bp from pter
Size:
20,921 bases
Orientation:
Minus strand

Genomic View for CD70 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD70 Gene

Proteins for CD70 Gene

  • Protein details for CD70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32970-CD70_HUMAN
    Recommended name:
    CD70 antigen
    Protein Accession:
    P32970
    Secondary Accessions:
    • B4DPR8
    • Q53XX4
    • Q96J57

    Protein attributes for CD70 Gene

    Size:
    193 amino acids
    Molecular mass:
    21118 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for CD70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD70 Gene

Proteomics data for CD70 Gene at MOPED

Post-translational modifications for CD70 Gene

  • Glycosylation at Asn63, Tyr74, and Asn170
  • Modification sites at PhosphoSitePlus

Other Protein References for CD70 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CD70 (CD27 Ligand/TNFSF7)

No data available for DME Specific Peptides for CD70 Gene

Domains for CD70 Gene

Gene Families for CD70 Gene

HGNC:
  • CD :CD molecules
  • TNFSF :Tumor necrosis factor (ligand) superfamily

Protein Domains for CD70 Gene

Graphical View of Domain Structure for InterPro Entry

P32970

UniProtKB/Swiss-Prot:

CD70_HUMAN :
  • P32970
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with CD70: view

Function for CD70 Gene

Molecular function for CD70 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells

Gene Ontology (GO) - Molecular Function for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 12777399
GO:0005102 receptor binding TAS 8120384
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 12324477
genes like me logo Genes that share ontologies with CD70: view

Phenotypes for CD70 Gene

MGI mutant phenotypes for CD70:
inferred from 2 alleles
GenomeRNAi human phenotypes for CD70:
genes like me logo Genes that share phenotypes with CD70: view

Animal Models for CD70 Gene

MGI Knock Outs for CD70:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD70

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD70 Gene

Localization for CD70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD70 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD70 Gene COMPARTMENTS Subcellular localization image for CD70 gene
Compartment Confidence
plasma membrane 4
extracellular 3

Gene Ontology (GO) - Cellular Components for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IDA 11920585
GO:0005887 integral component of plasma membrane TAS 8120384
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CD70: view

Pathways for CD70 Gene

genes like me logo Genes that share pathways with CD70: view

Pathways by source for CD70 Gene

PCR Array Products

Interacting Proteins for CD70 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000245903%0d%0a9606.ENSP00000266557%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000245903 P32970-CD70_HUMAN for CD70 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8387892
GO:0007267 cell-cell signaling TAS 8387892
GO:0008283 cell proliferation TAS 8120384
GO:0097191 extrinsic apoptotic signaling pathway IDA 9177220
genes like me logo Genes that share ontologies with CD70: view

Compounds for CD70 Gene

(4) Novoseek inferred chemical compound relationships for CD70 Gene

Compound -log(P) Hits PubMed IDs
hydralazine 42.4 4
procainamide 39.8 3
rantes 27.8 2
ionomycin 15.1 1
genes like me logo Genes that share compounds with CD70: view

Transcripts for CD70 Gene

mRNA/cDNA for CD70 Gene

Unigene Clusters for CD70 Gene

CD70 molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD70

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD70 Gene

No ASD Table

Relevant External Links for CD70 Gene

GeneLoc Exon Structure for
CD70
ECgene alternative splicing isoforms for
CD70

Expression for CD70 Gene

mRNA expression in normal human tissues for CD70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CD70 Gene

This gene is overexpressed in Liver (68.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CD70 Gene

SOURCE GeneReport for Unigene cluster for CD70 Gene Hs.501497

genes like me logo Genes that share expressions with CD70: view

Expression partners for CD70 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CD70 Gene

Orthologs for CD70 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD70 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD70 35
  • 72.87 (n)
  • 65.96 (a)
CD70 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD70 35
  • 77.37 (n)
  • 70.53 (a)
CD70 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd70 35
  • 64.25 (n)
  • 56.99 (a)
Cd70 16
Cd70 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd70 35
  • 64.59 (n)
  • 55.44 (a)
oppossum
(Monodelphis domestica)
Mammalia CD70 36
  • 35 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD70 36
  • 64 (a)
OneToOne
Species with no ortholog for CD70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD70 Gene

ENSEMBL:
Gene Tree for CD70 (if available)
TreeFam:
Gene Tree for CD70 (if available)

Paralogs for CD70 Gene

No data available for Paralogs for CD70 Gene

Variants for CD70 Gene

Sequence variations from dbSNP and Humsavar for CD70 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs171093 -- 6,589,415(+) gacag(A/G)atctc intron-variant
rs191499 -- 6,587,075(+) gagag(A/C)gagag intron-variant
rs344586 -- 6,588,220(+) tgtca(C/G)acact intron-variant
rs344587 -- 6,588,256(+) aaaga(A/G)ctgtc intron-variant
rs344588 -- 6,588,393(+) GAGGG(C/G)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD70 Gene

Variant ID Type Subtype PubMed ID
nsv833728 CNV Loss 17160897

Relevant External Links for CD70 Gene

HapMap Linkage Disequilibrium report
CD70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD70 Gene

Disorders for CD70 Gene

(1) University of Copenhagen DISEASES for CD70 Gene

(21) Novoseek inferred disease relationships for CD70 Gene

Disease -log(P) Hits PubMed IDs
necrosis 50.4 22
leukemia b-cell 45.8 1
lymphocytic leukemia chronic b-cell 41.7 1
lupus erythematosus systemic 40.2 2
tumors 36.9 50

Relevant External Links for CD70

Genetic Association Database (GAD)
CD70
Human Genome Epidemiology (HuGE) Navigator
CD70
genes like me logo Genes that share disorders with CD70: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CD70 Gene

Publications for CD70 Gene

  1. The cloning of CD70 and its identification as the ligand for CD27. (PMID: 8120384) Bowman M.R. … Herrmann S. (J. Immunol. 1994) 2 3 4
  2. Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. (PMID: 8387892) Goodwin R.G. … Beckmann M.P. (Cell 1993) 2 3 4
  3. Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells. (PMID: 19029446) Krause P. … Legler D.F. (Blood 2009) 3 23
  4. The CD70/CD27 pathway is critical for stimulation of an effective cytotoxic T cell response against B cell precursor acute lymphoblastic leukemia. (PMID: 19109206) Glouchkova L. … Dilloo D. (J. Immunol. 2009) 3 23
  5. Fyn and CD70 expression in CD4+ T cells from patients with systemic lupus erythematosus. (PMID: 19955046) Kozlowska A. … Jagodzinski P.P. (J. Rheumatol. 2010) 3 23

Products for CD70 Gene

Sources for CD70 Gene

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