Aliases for CD70 Gene
Aliases for CD70 Gene
External Ids for CD70 Gene
- HGNC: 11937
- Entrez Gene: 970
- Ensembl: ENSG00000125726
- OMIM: 602840
- UniProtKB: P32970
Previous HGNC Symbols for CD70 Gene
- CD27LG
- TNFSF7
Previous GeneCards Identifiers for CD70 Gene
- GC19M006537
- GC19M006538
- GC19M006346
Summaries for CD70 Gene
-
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD70 Gene
CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Chronic Lymphocytic Leukemia and Subacute Cutaneous Lupus Erythematosus. Among its related pathways are TNF Signaling (sino) and Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include receptor binding and protease binding.
UniProtKB/Swiss-Prot for CD70 Gene
-
Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD70 Gene
Genomics for CD70 Gene
Regulatory Elements for CD70 Gene
Enhancers for CD70 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CD70 on UCSC Golden Path with GeneCards custom track
Promoters for CD70 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around CD70 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CD70 gene promoter:
Regulatory Element Products
Genomic Location for CD70 Gene
- Chromosome:
- 19
- Start:
- 6,583,183 bp from pter
- End:
- 6,604,103 bp from pter
- Size:
- 20,921 bases
- Orientation:
- Minus strand
Genomic View for CD70 Gene
Genes around CD70 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13 by Entrez Gene
- 19p13 by HGNC
CD70 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD70 Gene
Proteins for CD70 Gene
-
Protein details for CD70 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P32970-CD70_HUMAN
- Recommended name:
- CD70 antigen
- Protein Accession:
- P32970
- B4DPR8
- Q53XX4
- Q96J57
Protein attributes for CD70 Gene
- Size:
- 193 amino acids
- Molecular mass:
- 21118 Da
- Quaternary structure:
-
- Homotrimer.
Protein Expression for CD70 Gene
Post-translational modifications for CD70 Gene
Other Protein References for CD70 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD70 (CD27 Ligand/TNFSF7)
- Novus Biologicals Antibodies for CD70
-
Cloud-Clone Corp. Antibodies for CD70
- Invitrogen Antibodies for CD70
- antibodies-online Antibodies for CD70: See all 221
- GeneTex CD70 antibody for CD70
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD70
Protein Products
- Enzo Life Sciences proteins for CD70
- Search Origene for MassSpec and Protein Over-expression Lysates for CD70
- Origene Custom Protein Services for CD70
- Sino Biological Cell Lysates for CD70
- Sino Biological Recombinant Proteins for CD70
-
Cloud-Clone Corp. Proteins for CD70
- antibodies-online Proteins for CD70: See all 35
- Search antibodies-online for peptides
- GeneTex sCD27 Ligand recombinant protein (GTX53820) for CD70
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CD70
-
Cloud-Clone Corp Assay Kits for CD70
- antibodies-online Kits for CD70: See all 8
No data available for DME Specific Peptides for CD70 Gene
Domains & Families for CD70 Gene
Gene Families for CD70 Gene
Protein Domains for CD70 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD70 Gene
Graphical View of Domain Structure for InterPro Entry
P32970- Family:
-
- Belongs to the tumor necrosis factor family.
Function for CD70 Gene
Molecular function for CD70 Gene
- UniProtKB/Swiss-Prot Function:
- Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 12324477 |
Phenotypes for CD70 Gene
- MGI mutant phenotypes for CD70:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CD70:
Animal Models for CD70 Gene
- MGI Knock Outs for CD70:
-
- Cd70 tm1.1Jda
Animal Model Products
-
Taconic Biosciences Mouse Models for CD70
-
ViGene Biosciences lentiviral particle packaged cDNA for CD70 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD70 gene
- Search ViGene Biosciences for CD70
CRISPR Products
-
OriGene CRISPR knockouts for CD70
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD70
- GenScript: Design CRISPR guide RNA sequences for CD70
miRNA for CD70 Gene
- miRTarBase miRNAs that target CD70
miRNA Products
- Search ViGene Biosciences for CD70
Clone Products
- OriGene clones in human for CD70
- OriGene ORF clones in human,mouse,rat for CD70
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD70
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for CD70 (CD27 Ligand/TNFSF7)
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CD70 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD70 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD70 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD70 Gene
Localization for CD70 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD70 Gene
- Membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 5 |
| cytosol | 2 |
| lysosome | 1 |
| vacuole | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for CD70 Gene
More details on SuperPathways for CD70| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
.47
|
|
| 2 | TNF Signaling (sino) |
.50
|
|
| 3 | ERK Signaling |
.61
|
|
| 4 | Akt Signaling |
.60
|
.60
|
| 5 | PAK Pathway |
.56
|
Pathways by source for CD70 Gene
3 Sino Biological pathways for CD70 Gene
4 Reactome pathways for CD70 Gene
1 KEGG pathway for CD70 Gene
1 GeneGo (Thomson Reuters) pathway for CD70 Gene
3 R&D Systems pathways for CD70 Gene
17 Qiagen pathways for CD70 Gene
Interacting Proteins for CD70 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007267 | cell-cell signaling | TAS | 8387892 |
Transcripts for CD70 Gene
mRNA/cDNA for CD70 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (44) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CD70 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CD70
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD70
- GenScript: Design CRISPR guide RNA sequences for CD70
miRNA Products
- Search ViGene Biosciences for CD70
Clone Products
- OriGene clones in human for CD70
- OriGene ORF clones in human,mouse,rat for CD70
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD70
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for CD70 (CD27 Ligand/TNFSF7)
Flow Cytometry Products
Expression for CD70 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Neural Crest (Gastrulation Derivatives)
- Blood (Hematopoietic System)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Kidney (Urinary System)
This gene is overexpressed in Liver (68.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD70 Gene
SOURCE GeneReport for Unigene cluster for CD70 Gene Hs.501497
Primer Products
-
OriGene qPCR primer pairs for CD70
-
OriGene qPCR primer pairs and template standards for CD70
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CD70 Gene
Orthologs for CD70 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CD70 35 |
|
||
| CD70 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CD70 35 |
|
||
| CD70 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Cd70 35 |
|
||
| Cd70 16 |
|
||||
| Cd70 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Cd70 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CD70 36 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | CD70 36 |
|
OneToOne |
- Species with no ortholog for CD70:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CD70 Gene
No data available for Paralogs for CD70 Gene
Variants for CD70 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs12979741 | -- | 6,586,901(+) | gagag(A/C)Caaaa | intron-variant | |
| rs62654154 | -- | 6,587,253(+) | GGGAG(A/T)GTGCA | intron-variant | |
| rs66653449 | -- | 6,589,937(+) | CTTCT(-/CTCT)GTCTC | intron-variant | |
| rs16994592 | -- | 6,586,487(+) | AGATA(C/T)AGAGA | intron-variant | |
| rs67650164 | -- | 6,589,851(+) | TGTCC(-/T)CGTCT | intron-variant |
Residual Variation Intolerance Score:
33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.78;
33.64% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CD70 Gene
Disorders for CD70 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chronic lymphocytic leukemia |
|
|
| subacute cutaneous lupus erythematosus |
|
|
| common variable immunodeficiency |
|
|
| corneal dystrophy, congenital stromal |
|
|
| renal cell carcinoma |
|
|
Search CD70 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CD70
No data available for UniProtKB/Swiss-Prot and Genatlas for CD70 Gene
Publications for CD70 Gene
- The cloning of CD70 and its identification as the ligand for CD27. (PMID: 8120384) Bowman M.R. … Herrmann S. (J. Immunol. 1994) 2 3 4 67
- Fyn and CD70 expression in CD4+ T cells from patients with systemic lupus erythematosus. (PMID: 19955046) Kozlowska A. … Jagodzinski P.P. (J. Rheumatol. 2010) 3 23
- Epigenetic silencing of TNFSF7 (CD70) by DNA methylation during progression to breast cancer. (PMID: 20119871) Yu S.E. … Jang Y.K. (Mol. Cells 2010) 3 23
- Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70. (PMID: 20139096) Shaw J. … Liu Y.J. (Blood 2010) 3 23
- Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation. (PMID: 20201989) Arimoto-Miyamoto K. … Uchiyama T. (Immunology 2010) 3 23
Products for CD70 Gene
- R&D Systems Antibodies for CD70 (CD27 Ligand/TNFSF7)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for CD70 (CD27 Ligand/TNFSF7)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CD70
- Custom Assay ServicesOriGene ELISA Kits for CD70
- Search Origene for MassSpec and Protein Over-expression Lysates for CD70
- Origene Custom Protein Services for CD70
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for CD70
- Browse OriGene Inhibitory RNA Products For CD70
- OriGene qPCR primer pairs for CD70
- OriGene qPCR primer pairs and template standards for CD70
- OriGene CRISPR knockouts for CD70
- OriGene clones in human for CD70
- OriGene ORF clones in human,mouse,rat for CD70
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for CD70
- GenScript Custom Assay Services for CD70
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- GenScript: Design CRISPR guide RNA sequences for CD70
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Plasmid Preparation
- GenScript Custom Peptide Services for CD70
- Sino Biological Human cDNA Clone for CD70
- Sino Biological Cell Lysates for CD70
- Sino Biological Recombinant Proteins for CD70
- 4000+ Proteins
- Search Sino Biological for antibodies, proteins & pathways
- Protein Production Services
- Transfection Reagents
- Protein A/G/L resins
- Isotyping reagents
- Novus Biologicals Antibodies for CD70
- Novus Biologicals proteins and lysates for CD70
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for CD70
- Cloud-Clone Corp. Proteins for CD70
- Cloud-Clone Corp Assay Kits for CD70
- Taconic Biosciences Mouse Models for CD70
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for CD70: See all 221
- antibodies-online Kits for CD70: See all 8
- antibodies-online Proteins for CD70: See all 35
- Search antibodies-online for peptides
- GeneTex CD70 antibody for CD70
- GeneTex sCD27 Ligand recombinant protein (GTX53820) for CD70
- ViGene Biosciences adenoviral particle packaged cDNA for CD70 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD70 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD70 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD70 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD70 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD70 gene
- Search ViGene Biosciences for CD70
- Search ViGene Biosciences for CD70
- Santa Cruz Biotechnology (SCBT) Antibodies for CD70
- Search Santa Cruz Biotechnology (SCBT) for CD70 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD70
Sources for CD70 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (25) DrugBank
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- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
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- (59) IMGT
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- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
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- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
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- (95) miRTarBase
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- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
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- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
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- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
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- (119) GeneReviews
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