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CD70 Gene

protein-coding   GIFtS: 58
GCID: GC19M006583

CD70 Molecule

(Previous names: tumor necrosis factor (ligand) superfamily, member 7)
(Previous symbols: CD27LG, TNFSF7)
  See CD70-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD70 Molecule1 2     CD27-L2 3
TNFSF71 2 3 5     CD27 Ligand2 3
CD27LG1 2 3     CD70 Antigen2 3
CD27L2 3 5     Ki-24 Antigen2
Tumor Necrosis Factor (Ligand) Superfamily, Member 71 2     Surface Antigen CD702
Tumor Necrosis Factor Ligand Superfamily Member 72 3     

External Ids:    HGNC: 119371   Entrez Gene: 9702   Ensembl: ENSG000001257267   OMIM: 6028405   UniProtKB: P329703   

Export aliases for CD70 gene to outside databases

Previous GC identifers: GC19M006537 GC19M006538 GC19M006346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD70 Gene:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B
lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and
contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation,
cytotoxic function of natural killer cells, and immunoglobulin sythesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD70 Gene:
CD70 (CD70 molecule) is a protein-coding gene. Diseases associated with CD70 include acute myocarditis, and myocarditis. GO annotations related to this gene include protease binding and receptor binding.

UniProtKB/Swiss-Prot: CD70_HUMAN, P32970
Function: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of
costimulated T-cells and enhances the generation of cytolytic T-cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD70 gene promoter:
         AP-1   ATF-2   c-Jun   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD70 promoter sequence
   Search Chromatin IP Primers for CD70

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13

CD70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD70 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006583:  view genomic region     (about GC identifiers)

Start:
6,583,194 bp from pter      End:
6,604,114 bp from pter
Size:
20,921 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CD70_HUMAN, P32970 (See protein sequence)
Recommended Name: CD70 antigen  
Size: 193 amino acids; 21118 Da
Subunit: Homotrimer (Probable)
Secondary accessions: Q53XX4 Q96J57

Explore the universe of human proteins at neXtProt for CD70: NX_P32970

Explore proteomics data for CD70 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn63, Tyr74, Asn170
  • Modification sites at PhosphoSitePlus

  • See CD70 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001243.1  
    ENSEMBL proteins: 
     ENSP00000395294   ENSP00000245903   ENSP00000470805  

    CD70 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CD70
    Sino Biological Cell Lysate for CD70
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD70 

     
    antibodies-online proteins for CD70 (17 products) 

     
    antibodies-online peptides for CD70

    CD70 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for CD70 (127 products) 

    CD70 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CD70 
    antibodies-online kits for CD70 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TNFSF: Tumor necrosis factor (ligand) superfamily

    3 InterPro protein domains:
     IPR021184 TNF_CS
     IPR006052 TNF_dom
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry P32970

    ProtoNet protein and cluster: P32970

    UniProtKB/Swiss-Prot: CD70_HUMAN, P32970
    Similarity: Belongs to the tumor necrosis factor family


    Find genes that share domains with CD70           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD70_HUMAN, P32970
    Function: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of
    costimulated T-cells and enhances the generation of cytolytic T-cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI12777399
    GO:0005102receptor binding TAS8120384
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding IPI12324477
         
    Find genes that share ontologies with CD70           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CD70:
     Decreased viability 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd70):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CD70           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cd70tm1.1Jda for CD70

       genOway: Develop your customized and physiologically relevant rodent model for CD70

    miRNA
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    Block miRNA regulation of human, mouse, rat CD70 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat CD70

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    GenScript: all cDNA clones in your preferred vector: CD70 (NM_001252)
    Sino Biological Human cDNA Clone for CD70
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD70
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD70

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CD70 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD70


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD70_HUMAN, P32970: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IDA11920585
    GO:0005887integral component of plasma membrane TAS8120384
    GO:0016020membrane ----
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with CD70           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD70 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    TNF Signaling0.50
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    Death Receptor Signaling0.50
    NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    3Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35


    Find genes that share SuperPaths with CD70           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CD70
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD70 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases
    MIF Mediated Glucocorticoid Regulation

    1 GeneGo (Thomson Reuters) Pathway for CD70
        Apoptosis and survival Apoptotic TNF-family pathways

    3 Sino Biological Pathways for CD70
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1 Kegg Pathway  (Kegg details for CD70):
        Cytokine-cytokine receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD70 (see all 9): 
              Cell Surface Markers in human mouse rat
              Apoptosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Type I Interferon Response in human mouse rat
              Common Cytokines in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD70

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CD70 (P329703 ENSP000002459034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD27P268423, ENSP000002665574I2D: score=2 STRING: ENSP00000266557
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS8387892
    GO:0007267cell-cell signaling TAS8387892
    GO:0008283cell proliferation TAS8120384
    GO:0097191extrinsic apoptotic signaling pathway IDA9177220

    Find genes that share ontologies with CD70           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD70

    4 Novoseek inferred chemical compound relationships for CD70 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydralazine 42.4 9 15879118 (2), 15188362 (1), 17911642 (1)
    procainamide 39.8 4 15879118 (2), 15188362 (1)
    rantes 27.8 2 14742640 (1), 12212969 (1)
    ionomycin 15.1 1 9143940 (1)



    Find genes that share compounds with CD70           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD70 gene: 
    NM_001252.4  

    Unigene Cluster for CD70:

    CD70 molecule
    Hs.501497  [show with all ESTs]
    Unigene Representative Sequence: BM464627
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423145(uc010xjf.1) ENST00000245903(uc002mfi.3) ENST00000597430

    miRNA
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    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CD70
      QuantiFast Probe-based Assays in human, mouse, rat CD70

    Additional mRNA sequence: 

    BC000725.2 BT007211.1 L08096.1 S69339.1 

    4 DOTS entries:

    DT.203123  DT.99973779  DT.100738158  DT.121468668 

    Selected AceView cDNA sequences (see all 44):

    BE273639 CR626341 BM464627 BQ933186 BU540451 BQ049765 BM477559 BM852184 
    NM_001252 BG751344 BT007211 L08096 AL560676 BG775537 BM046816 BC000725 
    BQ677350 BG421005 BG170786 BG752420 BM850868 BQ944266 BU540977 BE908993 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD70 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACACATCC
    CD70 Expression
    About this image


    CD70 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 4D20.8, NCr-fac Progenitor
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced SM30 cells
     
     Blood (Hematopoietic System)
             Tumor infiltrating lymphocytes (C?ntego)
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced SM30 cells
    CD70 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD70 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501497
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD70 (see all 9): 
              Cell Surface Markers in human mouse rat
              Apoptosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Type I Interferon Response in human mouse rat
              Common Cytokines in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD70

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD70 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd701 , 5 CD70 antigen1, 5 64.25(n)1
    56.99(a)1
      17 (29.69 cM)5
    219481  NM_011617.21  NP_035747.11 
     571459975 


    ENSEMBL Gene Tree for CD70 (if available)
    TreeFam Gene Tree for CD70 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD70 (see all 206)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2015935971,2
    C--6585359(+) AGAAC-/TTTTTTT 1 -- ds50010--------
    rs30555331,2
    C--6585374(+) TTTTT-/TT/TTT
            
    GACAA
    2 -- ds5001 cds11NA 2
    rs4325601,2
    C,F,A--6585378(+) tttgaT/Caagga 1 -- ds50017Minor allele frequency- C:0.43NA CSA WA EA 366
    rs81105811,2
    C,F,H--6585650(+) gcccaG/AccCAC 1 -- ds50019Minor allele frequency- A:0.02NS EA NA 752
    rs1452685921,2
    --6585746(+) AGTGGC/TGCAAT 1 -- ds50010--------
    rs81116151,2
    C--6585788(+) tcaagA/Cgattc 1 -- ds50010--------
    rs1857100081,2
    --6585840(+) GCCACA/GAAGCC 1 -- ds50010--------
    rs4270031,2
    C,F,A--6585842(+) CACGAA/CGCCCA 1 -- ds50018Minor allele frequency- C:0.50NA CSA WA EA 368
    rs4534621,2
    C--6585921(+) ACTACC/GCCCCA 1 -- ut31 ese38Minor allele frequency- G:0.00MN NA WA CSA 197
    rs729825181,2
    --6586005(+) AAATTA/TAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD70 (6583194 - 6604114 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CD70:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833728CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD70
    DNA2.0 Custom Variant and Variant Library Synthesis for CD70

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602840    OMIM disorders: --

    4 diseases for CD70:    
    About MalaCards
    acute myocarditis    myocarditis    subacute cutaneous lupus erythematosus    mantle cell lymphoma

    1 disease from the University of Copenhagen DISEASES database for CD70:
    Lupus erythematosus

    Find genes that share disorders with CD70           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD70 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 50.4 23 11980654 (2), 16547002 (1), 19760069 (1), 12709024 (1) (see all 21)
    leukemia b-cell 45.8 1 7540066 (1)
    lymphocytic leukemia chronic b-cell 41.7 1 7540066 (1)
    lupus erythematosus systemic 40.2 2 19955046 (1), 20223637 (1)
    tumors 36.9 56 11228533 (5), 9622100 (5), 16217761 (3), 15879877 (3) (see all 29)
    leukemia lymphocytic chronic 33 3 15356138 (1), 7540066 (1), 10221513 (1)
    autoimmunity 30.8 2 20035856 (1)
    carcinoma renal cell 29.2 4 17132225 (1), 15879877 (1), 16892042 (1)
    lymphoma 24.7 4 15356138 (1), 16272354 (1), 19806404 (1), 10419648 (1)
    glioblastoma 18.7 2 11980654 (1), 15958592 (1)

    Genetic Association Database (GAD): CD70
    Human Genome Epidemiology (HuGE) Navigator: CD70 (7 documents)

    Export disorders for CD70 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD70 gene, integrated from 10 sources (see all 168):
    (articles sorted by number of sources associating them with CD70)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning of CD70 and its identification as the ligand for CD27. (PubMed id 8120384)1, 2, 3 Bowman M.R....Herrmann S. (J. Immunol. 1994)
    2. Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. (PubMed id 8387892)1, 2, 3 Goodwin R.G.... Beckmann M.P. (Cell 1993)
    3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    6. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    7. Investigation of the NOTCH3 and TNFSF7 genes on C19p13 as candidates for migraine. (PubMed id 19018300)1, 4 Smith R.A....Griffiths L. (Open Neurol J 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation. (PubMed id 20201989)1, 9 Arimoto-Miyamoto K....Uchiyama T. (Immunology 2010)
    10. CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. (PubMed id 16892042)1, 9 Adam P.J....Harris A.L. (Br. J. Cancer 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 970 HGNC: 11937 AceView: TNFSF7 Ensembl:ENSG00000125726 euGenes: HUgn970
    ECgene: CD70 Kegg: 970 H-InvDB: CD70

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD70 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD70 gene:
    Search GeneIP for patents involving CD70

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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