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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD70 Gene

protein-coding   GIFtS: 59
GCID: GC19M006583

CD70 Molecule

(Previous names: tumor necrosis factor (ligand) superfamily, member 7)
(Previous symbols: CD27LG, TNFSF7)
  See related diseases
at
MalaCards
 

Aliases
for CD70 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
CD70 Molecule1 2     CD27-L2 3
TNFSF71 2 3 5     CD27 Ligand2 3
CD27LG1 2 3     CD70 Antigen2 3
CD27L2 3 5     Ki-24 Antigen2
Tumor Necrosis Factor (Ligand) Superfamily, Member 71 2     Surface Antigen CD702
Tumor Necrosis Factor Ligand Superfamily Member 72 3     

External Ids:    HGNC: 119371   Entrez Gene: 9702   Ensembl: ENSG000001257267   OMIM: 6028405   UniProtKB: P329703   

Export aliases for CD70 gene to outside databases

Previous GC identifers: GC19M006537 GC19M006538 GC19M006346


Summaries
for CD70 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD70 Gene:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This
cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B
lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and
contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation,
cytotoxic function of natural killer cells, and immunoglobulin sythesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD70 Gene: 
CD70 (CD70 molecule) is a protein-coding gene. Diseases associated with CD70 include acute myocarditis, and thymic carcinoma, and among its related super-pathways are TNF Signaling and STAT3 Pathway. GO annotations related to this gene include protease binding and receptor binding.

UniProtKB/Swiss-Prot: CD70_HUMAN, P32970
Function: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of
costimulated T-cells and enhances the generation of cytolytic T-cells




Genomic Views
for CD70 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD70 gene promoter:
         AP-1   ATF-2   c-Jun   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD70 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD70

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13

CD70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD70 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M006583:  view genomic region     (about GC identifiers)

Start:
 6,583,194 bp from pter      End:
 6,604,114 bp from pter
Size:
 20,921 bases      Orientation:
 minus strand

Proteins
for CD70 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: CD70_HUMAN, P32970 (See protein sequence)
Recommended Name: CD70 antigen  
Size: 193 amino acids; 21118 Da
Subunit: Homotrimer (Probable)
Subcellular location: Membrane; Single-pass type II membrane protein
Secondary accessions: Q96J57

Explore the universe of human proteins at neXtProt for CD70: NX_P32970

Explore proteomics data for CD70 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32970

    • CD70 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD70 Protein Expression
    REFSEQ proteins: NP_001243.1  
    ENSEMBL proteins: 
     ENSP00000395294   ENSP00000245903   ENSP00000470805  

    Human Recombinant Protein Products for CD70: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CD70
    OriGene Purified Protein for CD70
    OriGene Protein Over-expression Lysate for CD70
    OriGene MassSpec for CD70 
    OriGene Custom Protein Services for CD70
    GenScript Custom Purified and Recombinant Proteins Services for CD70
    Novus Biologicals CD70 Proteins
    Novus Biologicals CD70 Lysates
    Sino Biological Recombinant Protein for CD70
    Sino Biological Cell Lysate for CD70 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane IDA11920585
    GO:0005887integral to plasma membrane TAS8120384
    GO:0016020membrane ----

    CD70 for ontologies           About GeneDecksing



    CD70 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD70 (CD27 Ligand/TNFSF7)
    OriGene Antibodies for CD70
    OriGene Custom Antibody Services for CD70
    GenScript Custom Superior Antibodies Services for CD70
    Novus Biologicals CD70 Antibodies
    Abcam antibodies for CD70
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CD70
    LSBio Antibodies in human, mouse, rat for CD70 

    Assay Products for CD70: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD70
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD70
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.

    Protein Domains /
    Families
    for CD70 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    CD: CD molecules
    TNFSF: Tumor necrosis factor (ligand) superfamily

    3 InterPro protein domains:
     IPR021184 TNF_CS
     IPR006052 TNF
     IPR008983 Tumour_necrosis_fac-like_dom

    Graphical View of Domain Structure for InterPro Entry P32970

    ProtoNet protein and cluster: P32970

    UniProtKB/Swiss-Prot: CD70_HUMAN, P32970
    Similarity: Belongs to the tumor necrosis factor family


    CD70 for domains           About GeneDecksing


    Function
    for CD70 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD70_HUMAN, P32970
    Function: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of
    costimulated T-cells and enhances the generation of cytolytic T-cells

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI12777399
    GO:0005102receptor binding TAS8120384
    GO:0005125cytokine activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding IPI12324477
         
    CD70 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD70:
     Decreased viability 

         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cd70):
     hematopoietic system  immune system 

    CD70 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd70tm1.1Jda for CD70

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD70 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD70

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD70 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD70 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD70
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD70
    SwitchGear 3'UTR luciferase reporter plasmid: CD70 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD70
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD70

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD70
    Sirion Biotech Customized adenovirus for overexpression of CD70

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD70 (see all 6)
    OriGene ORF clones in mouse, rat for CD70
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD70 (NM_001252)
    Sino Biological Human cDNA Clone for CD70
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD70
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD70
    Sirion Biotech Customized lentivirus for stable overexpression of CD70 
                         Customized lentivirus expression plasmids for stable overexpression of CD70 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CD70
    Search LifeMap BioReagents cell lines for CD70
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD70


    Pathways & Interactions
    for CD70 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD70 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF Signaling
    		TNF Signaling0.50
    		TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions0.49
    		Death Receptor Signaling0.50
    		NF-kB (NFkB) Pathway0.46
    2PEDF Induced Signaling
    		Cytokine-cytokine receptor interaction0.43
    3Apoptosis and survival Apoptotic TNF-family pathways
    		Apoptosis and survival Apoptotic TNF-family pathways0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CD70
        Apoptosis and survival Apoptotic TNF-family pathways

    1 R&D Systems Pathway for CD70
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions


    1 GeneGo (Thomson Reuters) Pathway for CD70
        Apoptosis and survival Apoptotic TNF-family pathways

    3 Sino Biological Pathways for CD70 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway


    1         Kegg Pathway  (Kegg details for CD70):
        Cytokine-cytokine receptor interaction


    CD70 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD70

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CD70 (P329703 ENSP000002459034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD27P268423, ENSP000002665574I2D: score=2 STRING: ENSP00000266557
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS8387892
    GO:0007267cell-cell signaling TAS8387892
    GO:0008283cell proliferation TAS8120384
    GO:0097191extrinsic apoptotic signaling pathway IDA9177220

    CD70 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD70 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD70 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD70

    4 Novoseek inferred chemical compound relationships for CD70 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydralazine 42.4 9 15879118 (2), 15188362 (1), 17911642 (1)
    procainamide 39.8 4 15879118 (2), 15188362 (1)
    rantes 27.8 2 14742640 (1), 12212969 (1)
    ionomycin 15.1 1 9143940 (1)

    Search CenterWatch for drugs/clinical trials and news about CD70

    Transcripts
    for CD70 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD70 gene: 
    NM_001252.3  

    Unigene Clusters for CD70:

    CD70 molecule
    Hs.501497  [show with all ESTs], Hs.715224  [show with all ESTs]
    Unigene Representative Sequences: BM464627, AK298467
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423145(uc010xjf.1) ENST00000245903(uc002mfi.3) ENST00000597430

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD70
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD70
    SwitchGear 3'UTR luciferase reporter plasmid: CD70 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD70
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD70
    Clone
    Products:             		 OriGene clones in human, mouse for CD70 (see all 6)
    OriGene ORF clones in mouse, rat for CD70
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD70 (NM_001252)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD70
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD70
    Sirion Biotech Customized lentivirus for stable overexpression of CD70 
                         Customized lentivirus expression plasmids for stable overexpression of CD70 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for CD70
    OriGene qSTAR qPCR primer pairs in human, mouse for CD70
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD70
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD70
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD70

    Additional mRNA sequence: AK298467.1 

    4 DOTS entries:

    DT.203123  DT.99973779  DT.100738158  DT.121468668 

    24/44 AceView cDNA sequences (see all 44):

    CR626341 BQ049765 BQ933186 BM464627 BM477559 BU540451 BE273639 BG170786 
    BG751344 AL560676 BG752420 BQ018045 S69339 L08096 BT007211 BC000725 
    BM850868 BQ944266 BM920015 NM_001252 BG775537 BQ677350 BM046816 BM852184 

    GeneLoc Exon Structure


    Expression
    for CD70 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD70 expression in normal human tissues (normalized intensities)      CD70 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACACATCC
    CD70 Expression
    About this image


    CD70 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor E68
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Kidney (Urinary System)
             Human Renal Mesangial Cells (HRMC)   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 4D20.8, NCr-fac Progenitor
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See CD70 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD70

    SOURCE GeneReport for Unigene clusters: Hs.501497 Hs.715224
        SABiosciences Expression via Pathway-Focused PCR Arrays including CD70 (see all 9): 
              Cell Surface Markers in human mouse rat
              Apoptosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Type I Interferon Response in human mouse rat
              Common Cytokines in human mouse rat

    Primer
    Products:    		OriGene qPCR primer pairs and template standards for CD70
    OriGene qSTAR qPCR primer pairs in human, mouse for CD70
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD70
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD70
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD70
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD70

    Orthologs
    for CD70 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD70 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cd701 , 5 CD70 antigen1, 5 64.25(n)1
    56.99(a)1    		   17 (29.69 cM)5
    219481  NM_011617.21  NP_035747.11 
     571459975 


    ENSEMBL Gene Tree for CD70 (if available)
    TreeFam Gene Tree for CD70 (if available)

    Paralogs
    for CD70 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD70 gene
    1 SIMAP similar gene for CD70 using alignment to 3 protein entries:     CD70_HUMAN (see all proteins):
    TNFSF7

    CD70 for paralogs           About GeneDecksing



    Genomic Variants
    for CD70 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/206 SNPs in CD70 are shown (see all 206)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2015935971,2
    		C--6585359(+) AGAAC-/TTTTTTT 1 -- ds50010--------
    rs30555331,2
    		C--6585374(+) TTTTT-/TT/TTT
                GACAA     		2 -- ds5001 cds11NA 2
    rs4325601,2
    		C,F,A--6585378(+) tttgaT/Caagga 1 -- ds50017Minor allele frequency- C:0.43NA CSA WA EA 366
    rs81105811,2
    		C,F,H--6585650(+) gcccaG/AccCAC 1 -- ds50019Minor allele frequency- A:0.02NS EA NA 752
    rs1452685921,2
    		--6585746(+) AGTGGC/TGCAAT 1 -- ds50010--------
    rs81116151,2
    		C--6585788(+) tcaagA/Cgattc 1 -- ds50010--------
    rs1857100081,2
    		--6585840(+) GCCACA/GAAGCC 1 -- ds50010--------
    rs4270031,2
    		C,F,A--6585842(+) CACGAA/CGCCCA 1 -- ds50018Minor allele frequency- C:0.50NA CSA WA EA 368
    rs4534621,2
    		C--6585921(+) ACTACC/GCCCCA 1 -- ut31 ese38Minor allele frequency- G:0.00MN NA WA CSA 197
    rs729825181,2
    		--6586005(+) AAATTA/TAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CD70 (6583194 - 6604114 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CD70:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833728CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD70
    DNA2.0 Custom Variant and Variant Library Synthesis for CD70

    Disorders / Diseases
    for CD70 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 602840    OMIM disorders: --

    20/41 diseases for CD70 (see all 41):    About MalaCards
    acute myocarditis    thymic carcinoma    follicular lymphoma    macroglobulinemia
    myocarditis    waldenstrom macroglobulinemia    stomach cancer    interstitial lung disease
    clear cell renal cell carcinoma    common variable immunodeficiency    adult t-cell leukemia    mantle cell lymphoma
    hiv type 1    anaplastic large cell lymphoma    tonsillitis    renal cell carcinoma
    contact dermatitis    thrombocytopenia    migraine    lupus erythematosus

    1 disease from the University of Copenhagen DISEASES database for CD70:
    Lupus erythematosus

    CD70 for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for CD70 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 50.4 23 11980654 (2), 16547002 (1), 19760069 (1), 12709024 (1) (see all 21)
    leukemia b-cell 45.8 1 7540066 (1)
    lymphocytic leukemia chronic b-cell 41.7 1 7540066 (1)
    lupus erythematosus systemic 40.2 2 19955046 (1), 20223637 (1)
    tumors 36.9 56 11228533 (5), 9622100 (5), 16217761 (3), 15879877 (3) (see all 29)
    leukemia lymphocytic chronic 33 3 15356138 (1), 7540066 (1), 10221513 (1)
    autoimmunity 30.8 2 20035856 (1)
    carcinoma renal cell 29.2 4 17132225 (1), 15879877 (1), 16892042 (1)
    lymphoma 24.7 4 15356138 (1), 16272354 (1), 19806404 (1), 10419648 (1)
    glioblastoma 18.7 2 11980654 (1), 15958592 (1)

    Genetic Association Database (GAD): CD70
    Human Genome Epidemiology (HuGE) Navigator: CD70 (7 documents)

    Export disorders for CD70 gene to outside databases

    Publications
    for CD70 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD70 gene, integrated from 9 sources (see all 167):
    (articles sorted by number of sources associating them with CD70)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning of CD70 and its identification as the ligand for CD27. (PubMed id 8120384)1, 2, 3 Bowman M.R....Herrmann S. (1994)
    2. Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. (PubMed id 8387892)1, 2, 3 Goodwin R.G.... Beckmann M.P. (1993)
    3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    4. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    5. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    6. Common genetic variants in candidate genes and risk o f familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (2009)
    7. Investigation of the NOTCH3 and TNFSF7 Genes on C19p13 as Candidates for Migraine. (PubMed id 19018300)1, 4 Smith R.A....Griffiths L. (2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Optimal stimulation for CD70 induction on human monoc yte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell d ifferentiation. (PubMed id 20201989)1, 9 Arimoto-Miyamoto K....Uchiyama T. (2010)
    10. CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding. (PubMed id 16892042)1, 9 Adam P.J....Harris A.L. (2006)

    External Searches for CD70 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CD70 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 970 HGNC: 11937 AceView: TNFSF7 Ensembl:ENSG00000125726 euGenes: HUgn970
    ECgene: CD70 Kegg: 970 H-InvDB: CD70

    Other Databases showing CD70 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD70 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD70 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CD70 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD70 gene:
    Search GeneIP for patents involving CD70

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