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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD7 Gene

protein-coding   GIFtS: 65
GCID: GC17M080272

CD7 molecule

(Previous name: CD7 antigen (p41) )
 Explore 43 diseases affiliated with
CD7 via our new
 Human Malady Compendium 
Biological research products
for CD7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
CD7 Molecule1 2     T-Cell Leukemia Antigen2 3
GP401 2 3     T-Cell Surface Antigen Leu-92 3
TP411 2 3     P41 Protein2
LEU-91 2     T-Cell Antigen CD72
Tp401 2     CD7 Antigen3
CD7 Antigen (P41)1 2     

External Ids:    HGNC: 16951   Entrez Gene: 9242   Ensembl: ENSG000001737627   OMIM: 1868205   UniProtKB: P095643   

Export aliases for CD7 gene to outside databases

Previous GC identifers: GC17P079074 GC17M083187 GC17M080802 GC17M080951 GC17M077866 GC17M075671


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD7:
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on
thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction
during early lymphoid development. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD7_HUMAN, P09564
Function: Not yet known

Gene Wiki entry for CD7


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010663.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD7 gene promoter:
         GR   NF-1   p53   HTF   AREB6   POU2F1   POU2F1a   IRF-7A   ZIC2/Zic2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.2-q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.2-q25.3

CD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M080272:  view genomic region     (about GC identifiers)

Start:
80,272,744 bp from pter      End:
80,275,480 bp from pter
Size:
2,737 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD7_HUMAN, P09564 (See protein sequence)
Recommended Name: T-cell antigen CD7 precursor  
Size: 240 amino acids; 25409 Da
Subunit: Interacts with SECTM1
Subcellular location: Membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for CD7: NX_P09564

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09564

  • CD7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006128.1  
    ENSEMBL proteins: 
     ENSP00000463612   ENSP00000312027   ENSP00000463489   ENSP00000464565   ENSP00000464546  
     ENSP00000464182  

    Human Recombinant Protein Products: 
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    Novus Biologicals CD7 Lysates
    Sino Biological Recombinant Protein for CD7
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS3258561
    GO:0016020membrane TAS3501369
    GO:0016021integral to membrane TAS11485208


    CD7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CD7


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CD7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P09564

    ProtoNet protein and cluster: P09564

    1 Blocks protein family: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: CD7_HUMAN, P09564
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CD7_HUMAN, P09564
    Function: Not yet known

         Genatlas biochemistry entry for CD7:
    cell differentiation antigen CD7 (p41),40kDa,identified by monoclonal antibodies 3A1,4A,CL1.3,G3-7

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD7

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS11485208


    CD7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CD7:
     Decreased telomerase activity 

    Animal Models:
         Mouse knock-outs for CD7: Cd7tm1Fabo Cd7tm1Bfh
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd7):
     cellular  hematopoietic system  immune system 

    CD7 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Hematopoietic cell lineage
    Hematopoietic cell lineage1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for CD7):
        Hematopoietic cell lineage


    CD7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for CD7 (P095642, 3 ENSP000003120274) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8037058 I2D: score=4 STRING: ENSP00000274335
    LGALS1P093823, ENSP000002159094I2D: score=4 STRING: ENSP00000215909
    SECTM1Q8WVN63, ENSP000002693894I2D: score=3 STRING: ENSP00000269389
    PI4K2AQ9BTU63, ENSP000003596654I2D: score=1 STRING: ENSP00000359665
    SNAP29O957213, ENSP000002157304I2D: score=1 STRING: ENSP00000215730
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS11485208
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway NAS11485208
    GO:0042110T cell activation TAS11485208
    GO:0048873homeostasis of number of cells within a tissue IEA--


    CD7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD7
    Search CenterWatch for drugs/clinical trials and news about CD7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD7 gene: 
    NM_006137.6  

    Unigene Cluster for CD7:

    CD7 molecule
    Hs.36972  [show with all ESTs]
    Unigene Representative Sequence: AK310558
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000584284(uc010din.3) ENST00000312648(uc002kel.1) ENST00000583376
    ENST00000578509 ENST00000581744(uc010wvk.1) ENST00000581434 ENST00000582480


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    Inhib. RNA
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    Additional cDNA sequence: 

    AK223465.1 AK298096.1 AK310061.1 AK310558.1 BC009293.2 BC013297.2 BT006696.1 

    7 DOTS entries:

    DT.410148  DT.121002346  DT.92064360  DT.95286476  DT.95286475  DT.121002343  DT.95286474 

    24/68 AceView cDNA sequences (see all 68):

    CA438515 BQ882998 NM_006137 AW408338 BC009293 BI910424 BQ053679 AA355738 
    BP338651 BM917522 BC013297 CR608715 BI906419 BM919162 AA309959 BQ645811 
    BI838777 AW408337 BI907912 BT006696 AI697288 BM922347 BX448464 BI762916 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CD7 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b
    SP1:              -     -                 -                 -               
    SP2:                                      -                 -               
    SP3:              -     -     -           -                                 
    SP4:              -                       -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for CD7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCAAGGAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CD7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BloodPeripheral BloodNatural Killer CellsBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CD7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD7

    SOURCE GeneReport for Unigene cluster: Hs.36972
        SABiosciences Expression via Pathway-Focused PCR Arrays including CD7: 
              Cell Surface Markers in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD7 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd71 , 5 CD7 antigen1, 5 68.63(n)1
    54.9(a)1
      11 (84.85 cM)5
    125161  NM_009854.21  NP_033984.11 
     1210367475 
    chicken
    (Gallus gallus)
    Aves CD76
    Uncharacterized protein
    31(a)
    1 ↔ 1
    18(3684191-3688404)


    ENSEMBL Gene Tree for CD7 (if available)
    TreeFam Gene Tree for CD7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/137 NCBI SNPs in CD7 are shown (see all 137    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444588701,2
    --80272257(+) GGTGGC/TTCCTG 1 -- ds50010--------
    rs31768341,2
    C,--80272345(-) CTCCTC/AGTTCT 1 -- ds50015Minor allele frequency- A:0.17NA WA 282
    rs31768331,2
    F,--80272367(-) GCCCCG/ATCTTA 1 -- ds50012Minor allele frequency- A:0.03NA WA 158
    rs31768321,2
    F,--80272464(-) CCTCCC/TGAGGC 1 -- ds50013Minor allele frequency- T:0.03NA WA 198
    rs1452073231,2
    --80272490(+) GGGGGC/TCGGGG 1 -- ds50010--------
    rs31768311,2
    F,--80272491(-) CCCCCG/AACCCC 1 -- ds50013Minor allele frequency- A:0.08NA 200
    rs1819130791,2
    --80272526(+) TGAAGA/GGCCCC 1 -- ds50010--------
    rs1487079821,2
    --80272561(+) GTGGAC/TGTGCT 1 -- ds50010--------
    rs115750521,2
    F--80272607(-) CCCCAG/ACCCTG 1 -- ds50011Minor allele frequency- A:0.47NA 40
    rs115750511,2
    F--80272620(-) GAGCAC/ATTCCT 1 -- ds50011Minor allele frequency- A:0.10NA 40

    HapMap Linkage Disequilibrium report for CD7 (80272744 - 80275480 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CD7
         2 CNVs: 5043 73078

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CD7 for disorders           About GeneDecksing

    OMIM gene information: 186820    OMIM disorders: --

    20/43 diseases for CD7 (see all 43):    About MalaCards
    pityriasis lichenoides et varioliformis acuta    pityriasis lichenoides    t-cell leukemia    leukemia
    human t-cell leukemia virus type 1    lymphomatoid papulosis    mycosis fungoides    malignant pleural mesothelioma
    systemic lupus erythematosus    prolymphocytic leukemia    severe combined immunodeficiency    systemic lupus erythematosus, association with
    malignant mesothelioma    t-cell prolymphocytic leukemia    primary effusion lymphoma    lupus erythematosus
    combined immunodeficiency    lymphoblastic leukemia    strongyloidiasis    acute promyelocytic leukemia

    2 diseases from the University of Copenhagen DISEASES database for CD7:
    Leukemia     Lymphoma

    10/21 Novoseek disease relationships for CD7 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia nonlymphocytic acute 58.8 2 1711009 (1), 1701841 (1)
    lymphoma t-cell 58.7 3 12397782 (2), 9258765 (1)
    t-all 58.6 4 11195181 (1), 11300488 (1), 7511331 (1)
    mycosis fungoides 55.8 4 1690762 (4)
    leukemia t-cell 55.2 4 12397782 (3), 1527057 (1)
    lymphoma lymphoblastic 53.7 2 1701841 (1), 7741140 (1)
    leukemia 52.2 8 20046078 (1), 9402326 (1), 16121214 (1), 1695699 (1) (see all 7)
    lymphoblastic leukemia acute 47.3 3 9402326 (1), 7678882 (1), 7741140 (1)
    sezary syndrome 47.3 4 1690762 (3), 11209115 (1)
    acute leukemia 46.2 1 1701841 (1)

    Human Genome Epidemiology (HuGE) Navigator: CD7 (5 documents)

    Export disorders for CD7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD7 gene, integrated from 9 sources (see all 128):
    (articles sorted by number of sources associating them with CD7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. (PubMed id 3501369)1, 2, 3 Aruffo A. and Seed B. (1987)
    2. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. (PubMed id 10652336)1, 2, 9 Lyman S.D.... Fanslow W.C. (2000)
    3. Molecular cloning of the gene coding for the human T cell differentiation antigen CD7. (PubMed id 1711009)1, 2, 9 Yoshikawa K....Takahashi T. (1991)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. (PubMed id 1703303)1, 2 Schanberg L.E.... Kaufman R.E. (1991)
    6. Localization of the cell surface antigen CD7 by chromosomal in situ hybridization. (PubMed id 1695199)1, 3 Baker E....Webber L.M. (1990)
    7. Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. (PubMed id 2479685)1, 2 Ware R.E....Haynes B.F. (1989)
    8. Frequent CD7 antigen loss in aggressive natural kille r-cell leukemia: a useful diagnostic marker. (PubMed id 20046078)1, 9 Yoo E.H....Kim S.H. (2009)
    9. Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover. (PubMed id 12594831)1, 9 Subrahmanyam G....Schneider H. (2003)
    10. Role of CD7 expressed in lung microvascular endothelial cells as Fc receptor for immunoglobulin M. (PubMed id 16990185)1, 9 Nishimura M....Nakajima K. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 924 HGNC: 1695 AceView: CD7 Ensembl:ENSG00000173762 euGenes: HUgn924
    ECgene: CD7 Kegg: 924 H-InvDB: CD7

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for CD7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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