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CD7 Gene

protein-coding   GIFtS: 66
GCID: GC17M080272

CD7 Molecule

(Previous name: CD7 antigen (p41))
  See CD7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD7 Molecule1 2     TP412 3
T-Cell Leukemia Antigen1 2 3     T-Cell Surface Antigen Leu-92 3
CD7 Antigen (P41)1 2     LEU-92
P41 Protein1 2     Tp402
T-Cell Antigen CD71 2     CD7 Antigen3
GP402 3     

External Ids:    HGNC: 16951   Entrez Gene: 9242   Ensembl: ENSG000001737627   OMIM: 1868205   UniProtKB: P095643   

Export aliases for CD7 gene to outside databases

Previous GC identifers: GC17P079074 GC17M083187 GC17M080802 GC17M080951 GC17M077866 GC17M075671


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD7 Gene:
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is
found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in
T-cell/B-cell interaction during early lymphoid development. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD7 Gene:
CD7 (CD7 molecule) is a protein-coding gene. Diseases associated with CD7 include pityriasis lichenoides et varioliformis acuta, and hepatosplenic t-cell lymphoma. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot: CD7_HUMAN, P09564
Function: Not yet known

Gene Wiki entry for CD7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010663.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD7 gene promoter:
         GR   NF-1   p53   HTF   AREB6   POU2F1   POU2F1a   IRF-7A   ZIC2/Zic2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD7 promoter sequence
   Search Chromatin IP Primers for CD7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.2-q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.2-q25.3

CD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M080272:  view genomic region     (about GC identifiers)

Start:
80,272,744 bp from pter      End:
80,275,480 bp from pter
Size:
2,737 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD7_HUMAN, P09564 (See protein sequence)
Recommended Name: T-cell antigen CD7 precursor  
Size: 240 amino acids; 25409 Da
Subunit: Interacts with SECTM1

Explore the universe of human proteins at neXtProt for CD7: NX_P09564

Explore proteomics data for CD7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn45, Asn96
  • Modification sites at PhosphoSitePlus

  • See CD7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006128.1  
    ENSEMBL proteins: 
     ENSP00000463612   ENSP00000312027   ENSP00000463489   ENSP00000464565   ENSP00000464546  
     ENSP00000464182  

    CD7 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CD7
    Sino Biological Cell Lysate for CD7
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    Cloud-Clone Corp. Proteins for CD7

     
    Search eBioscience for Proteins for CD7 

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    CD7 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P09564

    ProtoNet protein and cluster: P09564

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: CD7_HUMAN, P09564
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    Find genes that share domains with CD7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD7_HUMAN, P09564
    Function: Not yet known

         Genatlas biochemistry entry for CD7:
    cell differentiation antigen CD7 (p41),40kDa,identified by monoclonal antibodies 3A1,4A,CL1.3,G3-7

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS11485208
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CD7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CD7:
     Decreased telomerase activity 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd7):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CD7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD7: Cd7tm1Fabo Cd7tm1Bfh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD7

    miRNA
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    Block miRNA regulation of human, mouse, rat CD7 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat CD7

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CD7 (NM_006137)
    Sino Biological Human cDNA Clone for CD7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD7

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD7_HUMAN, P09564: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS1695199
    GO:0016020membrane TAS3501369
    GO:0016021integral component of membrane TAS11485208

    Find genes that share ontologies with CD7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD7 About    
    See pathways by source

    SuperPathContained pathways About
    1Hematopoietic cell lineage
    Hematopoietic cell lineage


    Find genes that share SuperPaths with CD7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for CD7):
        Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD7: 
              Cell Surface Markers in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for CD7 (P095642, 3 ENSP000003120274) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8037058 I2D: score=4 STRING: ENSP00000274335
    LGALS1P093823, ENSP000002159094I2D: score=4 STRING: ENSP00000215909
    SECTM1Q8WVN63, ENSP000002693894I2D: score=3 STRING: ENSP00000269389
    PI4K2AQ9BTU63, ENSP000003596654I2D: score=1 STRING: ENSP00000359665
    SNAP29O957213, ENSP000002157304I2D: score=1 STRING: ENSP00000215730
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS11485208
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway NAS11485208
    GO:0042110T cell activation TAS11485208
    GO:0048873homeostasis of number of cells within a tissue IEA--

    Find genes that share ontologies with CD7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD7 gene: 
    NM_006137.6  

    Unigene Cluster for CD7:

    CD7 molecule
    Hs.36972  [show with all ESTs]
    Unigene Representative Sequence: AK310558
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000584284(uc010din.3) ENST00000312648(uc002kel.1) ENST00000583376
    ENST00000578509 ENST00000581744(uc010wvk.1) ENST00000581434 ENST00000582480

    miRNA
    Products:
         
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    SwitchGear 3'UTR luciferase reporter plasmidCD7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD7
    OriGene qSTAR qPCR primer pairs in human, mouse for CD7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD7
      QuantiTect SYBR Green Assays in human, mouse, rat CD7
      QuantiFast Probe-based Assays in human, mouse, rat CD7

    Additional mRNA sequence: 

    AK223465.1 AK298096.1 AK310061.1 AK310558.1 BC009293.2 BC013297.2 BT006696.1 

    7 DOTS entries:

    DT.410148  DT.121002346  DT.92064360  DT.95286476  DT.95286475  DT.121002343  DT.95286474 

    Selected AceView cDNA sequences (see all 68):

    BC009293 BI910424 CR608715 AA355738 BP338651 AW408338 BQ053679 NM_006137 
    BM917522 BQ882998 CA438515 BC013297 BM922430 BI906419 BI762916 AI829961 
    BI838777 AL532305 BF128668 AI880790 AI697288 BQ645811 X06180 AW027486 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD7 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b
    SP1:              -     -                 -                 -               
    SP2:                                      -                 -               
    SP3:              -     -     -           -                                 
    SP4:              -                       -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for CD7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGGAGG
    CD7 Expression
    About this image


    CD7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Natural Killer Cells Peripheral Blood
             Peripheral blood Pan-T Cells   
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Umbilical Cord (Extraembryonic Tissues)
             Cord Blood Natural Killer Cells (CD56+)   
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Dental pulp stem cells
     
     Liver (Hepatobiliary System)
    CD7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.36972
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD7: 
              Cell Surface Markers in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD7 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd71 , 5 CD7 antigen1, 5 68.59(n)1
    52.88(a)1
      11 (84.85 cM)5
    125161  NM_009854.21  NP_033984.11 
     1210367475 


    ENSEMBL Gene Tree for CD7 (if available)
    TreeFam Gene Tree for CD7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD7 gene
    1 SIMAP similar gene for CD7 using alignment to 7 protein entries:     CD7_HUMAN (see all proteins):
    IGSF11

    Find genes that share paralogs with CD7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD7 (see all 195)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444588701,2
    --80272257(+) GGTGGC/TTCCTG 1 -- ds50010--------
    rs31768341,2
    C--80272345(-) CTCCTC/AGTTCT 1 -- ds50015Minor allele frequency- A:0.17NA WA 282
    rs31768331,2
    F--80272367(-) GCCCCG/ATCTTA 1 -- ds50012Minor allele frequency- A:0.03NA WA 158
    rs31768321,2
    F--80272464(-) CCTCCC/TGAGGC 1 -- ds50013Minor allele frequency- T:0.03NA WA 198
    rs1452073231,2
    C--80272490(+) GGGGGC/TCGGGG 1 -- ds50010--------
    rs31768311,2
    F--80272491(-) CCCCCG/AACCCC 1 -- ds50013Minor allele frequency- A:0.08NA 200
    rs1819130791,2
    --80272526(+) TGAAGA/GGCCCC 1 -- ds50010--------
    rs1487079821,2
    C--80272561(+) GTGGAC/TGTGCT 1 -- ds50010--------
    rs115750521,2
    F--80272607(-) CCCCAG/ACCCTG 1 -- ds50011Minor allele frequency- A:0.47NA 40
    rs115750511,2
    F--80272620(-) GAGCAC/ATTCCT 1 -- ds50011Minor allele frequency- A:0.10NA 40

    HapMap Linkage Disequilibrium report for CD7 (80272744 - 80275480 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CD7 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3354n71CNV Loss21882294
    dgv3357n71CNV Loss21882294
    dgv3353n71CNV Loss21882294
    nsv909134CNV Loss21882294
    dgv3356n71CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3355n71CNV Loss21882294
    nsv909208CNV Loss21882294
    nsv833573CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD7
    DNA2.0 Custom Variant and Variant Library Synthesis for CD7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186820    OMIM disorders: --

    12 diseases for CD7:    
    About MalaCards
    pityriasis lichenoides et varioliformis acuta    hepatosplenic t-cell lymphoma    pityriasis lichenoides    t-cell leukemia
    strongyloidiasis    adult t-cell leukemia    malignant pleural mesothelioma    acute leukemia
    acute promyelocytic leukemia    leukemia    chronic myeloid leukemia    acute myeloid leukemia

    2 diseases from the University of Copenhagen DISEASES database for CD7:
    Leukemia     Lymphoma

    Find genes that share disorders with CD7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD7 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia nonlymphocytic acute 58.8 2 1711009 (1), 1701841 (1)
    lymphoma t-cell 58.7 3 12397782 (2), 9258765 (1)
    t-all 58.6 4 11195181 (1), 11300488 (1), 7511331 (1)
    mycosis fungoides 55.8 4 1690762 (4)
    leukemia t-cell 55.2 4 12397782 (3), 1527057 (1)
    lymphoma lymphoblastic 53.7 2 1701841 (1), 7741140 (1)
    leukemia 52.2 8 20046078 (1), 9402326 (1), 16121214 (1), 1695699 (1) (see all 7)
    lymphoblastic leukemia acute 47.3 3 9402326 (1), 7678882 (1), 7741140 (1)
    sezary syndrome 47.3 4 1690762 (3), 11209115 (1)
    acute leukemia 46.2 1 1701841 (1)

    Human Genome Epidemiology (HuGE) Navigator: CD7 (5 documents)

    Export disorders for CD7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD7 gene, integrated from 10 sources (see all 130):
    (articles sorted by number of sources associating them with CD7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. (PubMed id 3501369)1, 2, 3 Aruffo A. and Seed B. (EMBO J. 1987)
    2. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. (PubMed id 10652336)1, 2, 9 Lyman S.D.... Fanslow W.C. (J. Biol. Chem. 2000)
    3. Molecular cloning of the gene coding for the human T cell differentiation antigen CD7. (PubMed id 1711009)1, 2, 9 Yoshikawa K....Takahashi T. (Immunogenetics 1991)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. (PubMed id 1703303)1, 2 Schanberg L.E.... Kaufman R.E. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    6. Localization of the cell surface antigen CD7 by chromosomal in situ hybridization. (PubMed id 1695199)1, 3 Baker E....Webber L.M. (Immunogenetics 1990)
    7. Characterization of the surface topography and putative tertiary structure of the human CD7 molecule. (PubMed id 2479685)1, 2 Ware R.E....Haynes B.F. (J. Immunol. 1989)
    8. Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker. (PubMed id 20046078)1, 9 Yoo E.H....Kim S.H. (Korean J Lab Med 2009)
    9. Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover. (PubMed id 12594831)1, 9 Subrahmanyam G....Schneider H. (Eur. J. Immunol. 2003)
    10. Role of CD7 expressed in lung microvascular endothelial cells as Fc receptor for immunoglobulin M. (PubMed id 16990185)1, 9 Nishimura M....Nakajima K. (Endothelium 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 924 HGNC: 1695 AceView: CD7 Ensembl:ENSG00000173762 euGenes: HUgn924
    ECgene: CD7 Kegg: 924 H-InvDB: CD7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD7 gene:
    Search GeneIP for patents involving CD7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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