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CD7 Gene(Protein Coding)

CD7 Molecule

GCID:
GC17M082314
GIFtS:
58
Genes Participants
UDN Logo

Aliases for CD7 Gene

Aliases for CD7 Gene

  • CD7 Molecule 2 3 5
  • T-Cell Leukemia Antigen 2 3 4
  • T-Cell Surface Antigen Leu-9 3 4
  • T-Cell Antigen CD7 2 3
  • CD7 Antigen (P41) 2 3
  • P41 Protein 2 3
  • GP40 3 4
  • TP41 3 4
  • CD7 Antigen 4
  • LEU-9 3
  • Tp40 3

External Ids for CD7 Gene

Previous GeneCards Identifiers for CD7 Gene

  • GC17P079074
  • GC17M083187
  • GC17M080802
  • GC17M080951
  • GC17M077866
  • GC17M080272
  • GC17M075671

Summaries for CD7 Gene

Entrez Gene Summary for CD7 Gene

  • This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD7 Gene

CD7 (CD7 Molecule) is a Protein Coding gene. Diseases associated with CD7 include Pityriasis Lichenoides Et Varioliformis Acuta and T-Cell Leukemia. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Hematopoietic cell lineage. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for CD7 Gene

  • Not yet known.

Gene Wiki entry for CD7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD7 Gene

Genomics for CD7 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CD7 Gene

Enhancers for CD7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G082337 1.5 Ensembl ENCODE dbSUPER 13.1 -21.2 -21166 2.3 ATF1 ARID4B SIN3A YY1 ZNF121 ZNF766 GLIS2 ELK1 ZNF143 FOS TEX19 CD7 LOC105376790 SECTM1
GH17G082200 1.5 FANTOM5 ENCODE dbSUPER 9.5 +116.7 116690 1.8 HDAC1 HDGF TBP PKNOX1 TBL1XR1 ARNT NFRKB ZBTB40 TCF12 ELK1 CCDC57 HGS NARF-IT1 ACTG1 TEPSIN ENSG00000262049 ARHGDIA ALYREF CD7 HEXDC
GH17G082291 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4 +19.0 18971 14.7 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 TEX19 CSNK1D SLC16A3 SECTM1 CCDC57 HGS ACTG1 ENSG00000262877 ENSG00000262049 ARHGDIA
GH17G082256 1.3 FANTOM5 ENCODE dbSUPER 1.4 +60.3 60252 1.4 SCRT1 CTCF PKNOX1 ZNF146 RFX1 NFYC SP2 RAD21 POLR2A PBX2 SLC16A3 DCXR CSNK1D C17orf62 CCDC57 NARF CD7 WDR45B SIRT7 PIR35303
GH17G082313 1.5 Ensembl ENCODE dbSUPER 0.7 +1.6 1552 4.7 AGO1 ZNF493 ZFP64 ARID4B DMAP1 ZNF48 SP5 ZHX2 REST PPARG ENSG00000262877 TEX19 ALYREF GPS1 MCRIP1 CSNK1D UTS2R CD7 ENSG00000260563
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD7 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CD7 gene promoter:

Genomic Location for CD7 Gene

Chromosome:
17
Start:
82,314,865 bp from pter
End:
82,317,604 bp from pter
Size:
2,740 bases
Orientation:
Minus strand

Genomic View for CD7 Gene

Genes around CD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD7 Gene

Proteins for CD7 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09564-CD7_HUMAN
    Recommended name:
    T-cell antigen CD7
    Protein Accession:
    P09564

    Protein attributes for CD7 Gene

    Size:
    240 amino acids
    Molecular mass:
    25409 Da
    Quaternary structure:
    • Interacts with SECTM1.

neXtProt entry for CD7 Gene

Protein Expression for CD7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD7 Gene

  • Glycosylation at posLast=4545 and Asn96
  • Modification sites at PhosphoSitePlus

Other Protein References for CD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD7 Gene

Domains & Families for CD7 Gene

Gene Families for CD7 Gene

HGNC:

Protein Domains for CD7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD7: view

No data available for UniProtKB/Swiss-Prot for CD7 Gene

Function for CD7 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CD7 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD7 (p41),40kDa,identified by monoclonal antibodies 3A1,4A,CL1.3,G3-7
UniProtKB/Swiss-Prot Function:
Not yet known.

Gene Ontology (GO) - Molecular Function for CD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 11485208
genes like me logo Genes that share ontologies with CD7: view
genes like me logo Genes that share phenotypes with CD7: view

Animal Models for CD7 Gene

MGI Knock Outs for CD7:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD7 Gene

Localization for CD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD7 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
cytosol 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 1695199
GO:0016020 membrane IEA,TAS 3501369
GO:0016021 integral component of membrane TAS,IEA 11485208
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CD7: view

Pathways & Interactions for CD7 Gene

genes like me logo Genes that share pathways with CD7: view

Pathways by source for CD7 Gene

1 KEGG pathway for CD7 Gene
1 R&D Systems pathway for CD7 Gene

Gene Ontology (GO) - Biological Process for CD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006955 immune response TAS 11485208
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS 11485208
GO:0042110 T cell activation TAS 11485208
genes like me logo Genes that share ontologies with CD7: view

No data available for SIGNOR curated interactions for CD7 Gene

Drugs & Compounds for CD7 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CD7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CD7 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD7 Gene

CD7 molecule:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5:
SP6: - -

Relevant External Links for CD7 Gene

GeneLoc Exon Structure for
CD7
ECgene alternative splicing isoforms for
CD7

Expression for CD7 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD7 Gene

mRNA expression in normal human tissues for CD7 Gene
mRNA expression by BioGPS for CD7 GenemRNA expression by GTEx for CD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD7 Gene

This gene is overexpressed in Whole Blood (x31.4) and Spleen (x6.1).

Protein differential expression in normal tissues from HIPED for CD7 Gene

This gene is overexpressed in NK cells (22.6), Urine (18.1), CD8 Tcells (11.5), and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD7 Gene



Protein tissue co-expression partners for CD7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD7 Gene:

CD7

SOURCE GeneReport for Unigene cluster for CD7 Gene:

Hs.36972

Evidence on tissue expression from TISSUES for CD7 Gene

  • Liver(4.3)
  • Muscle(4)
  • Blood(3.6)
  • Bone marrow(3.3)
  • Lymph node(2.8)
  • Spleen(2.4)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CD7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD7 Gene

Orthologs for CD7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CD7 34 35
  • 98.02 (n)
dog
(Canis familiaris)
 Mammalia CD7 34 35
  • 70.99 (n)
cow
(Bos Taurus)
 Mammalia CD7 34 35
  • 70.92 (n)
mouse
(Mus musculus)
 Mammalia Cd7 34 16 35
  • 68.59 (n)
rat
(Rattus norvegicus)
 Mammalia Cd7 34
  • 67.89 (n)
oppossum
(Monodelphis domestica)
 Mammalia CD7 35
  • 35 (a)
 OneToOne
Species where no ortholog for CD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD7 Gene

ENSEMBL:
Gene Tree for CD7 (if available)
TreeFam:
Gene Tree for CD7 (if available)

Paralogs for CD7 Gene

(1) SIMAP similar genes for CD7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CD7: view

No data available for Paralogs for CD7 Gene

Variants for CD7 Gene

Sequence variations from dbSNP and Humsavar for CD7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000433348 -- 82,315,242(+) GAGGG(A/G)TGTGG nc-transcript-variant, utr-variant-3-prime
rs1000813476 -- 82,315,703(+) CCAGA(C/G)AAACA intron-variant
rs1001155664 -- 82,315,610(+) GGGTC(A/G)GACCC intron-variant
rs1001910729 -- 82,319,979(+) CTCCT(G/T)CCCCA nc-transcript-variant
rs1002051385 -- 82,317,201(+) TTCCT(-/CCCAAAGCAGCGG)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD7 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2760445 CNV gain 21179565
esv2762577 CNV gain+loss 21179565
nsv1059334 CNV gain 25217958
nsv1067194 CNV gain 25217958
nsv428351 CNV gain 18775914
nsv469561 CNV loss 16826518
nsv833572 CNV loss 17160897
nsv833573 CNV loss 17160897
nsv952394 CNV deletion 24416366

Variation tolerance for CD7 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD7 Gene

Disorders for CD7 Gene

MalaCards: The human disease database

(22) MalaCards diseases for CD7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pityriasis lichenoides et varioliformis acuta
  • mucha-habermann disease
t-cell leukemia
  • leukemia t-cell
lymphoblastic lymphoma
  • lymphoma, lymphoblastic
pityriasis lichenoides
mycosis fungoides
  • mf
- elite association - COSMIC cancer census association via MalaCards
Search CD7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD7

Human Genome Epidemiology (HuGE) Navigator
CD7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD7
genes like me logo Genes that share disorders with CD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD7 Gene

Publications for CD7 Gene

  1. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. (PMID: 10652336) Lyman S.D. … Fanslow W.C. (J. Biol. Chem. 2000) 3 4 22 64
  2. Molecular cloning of the gene coding for the human T cell differentiation antigen CD7. (PMID: 1711009) Yoshikawa K. … Takahashi T. (Immunogenetics 1991) 3 4 22 64
  3. Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. (PMID: 3501369) Aruffo A. … Seed B. (EMBO J. 1987) 2 3 4 64
  4. Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker. (PMID: 20046078) Yoo E.H. … Kim S.H. (Korean J Lab Med 2009) 3 22 64
  5. CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia. (PMID: 16332967) Bremer E. … Helfrich W. (Blood 2006) 3 22 64

Products for CD7 Gene

Sources for CD7 Gene

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