Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD7 Gene

Aliases for CD7 Gene

  • CD7 Molecule 2 3 5
  • T-Cell Leukemia Antigen 2 3 4
  • T-Cell Surface Antigen Leu-9 3 4
  • CD7 Antigen (P41) 2 3
  • P41 Protein 2 3
  • GP40 3 4
  • TP41 3 4
  • T-Cell Antigen CD7 2
  • CD7 Antigen 4
  • LEU-9 3
  • Tp40 3

External Ids for CD7 Gene

Previous GeneCards Identifiers for CD7 Gene

  • GC17P079074
  • GC17M083187
  • GC17M080802
  • GC17M080951
  • GC17M077866
  • GC17M080272
  • GC17M075671

Summaries for CD7 Gene

Entrez Gene Summary for CD7 Gene

  • This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD7 Gene

CD7 (CD7 Molecule) is a Protein Coding gene. Diseases associated with CD7 include T-Cell Leukemia and Pityriasis Lichenoides Et Varioliformis Acuta. Among its related pathways are Hematopoietic cell lineage and Innate Lymphoid Cell Differentiation Pathways. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for CD7 Gene

  • Not yet known.

Gene Wiki entry for CD7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD7 Gene

Genomics for CD7 Gene

Regulatory Elements for CD7 Gene

Enhancers for CD7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD7 on UCSC Golden Path with GeneCards custom track

Promoters for CD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD7 Gene

Chromosome:
17
Start:
82,314,865 bp from pter
End:
82,317,604 bp from pter
Size:
2,740 bases
Orientation:
Minus strand

Genomic View for CD7 Gene

Genes around CD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD7 Gene

Proteins for CD7 Gene

  • Protein details for CD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09564-CD7_HUMAN
    Recommended name:
    T-cell antigen CD7
    Protein Accession:
    P09564

    Protein attributes for CD7 Gene

    Size:
    240 amino acids
    Molecular mass:
    25409 Da
    Quaternary structure:
    • Interacts with SECTM1.

neXtProt entry for CD7 Gene

Proteomics data for CD7 Gene at MOPED

Post-translational modifications for CD7 Gene

  • Glycosylation at Asn 45 and Asn 96
  • Modification sites at PhosphoSitePlus

Other Protein References for CD7 Gene

No data available for DME Specific Peptides for CD7 Gene

Domains & Families for CD7 Gene

Gene Families for CD7 Gene

Protein Domains for CD7 Gene

Suggested Antigen Peptide Sequences for CD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09564

UniProtKB/Swiss-Prot:

CD7_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD7: view

Function for CD7 Gene

Molecular function for CD7 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD7 (p41),40kDa,identified by monoclonal antibodies 3A1,4A,CL1.3,G3-7
UniProtKB/Swiss-Prot Function:
Not yet known.
genes like me logo Genes that share phenotypes with CD7: view

Animal Models for CD7 Gene

MGI Knock Outs for CD7:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD7 Gene

Localization for CD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD7 Gene COMPARTMENTS Subcellular localization image for CD7 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CD7 Gene

Pathways & Interactions for CD7 Gene

genes like me logo Genes that share pathways with CD7: view

Pathways by source for CD7 Gene

1 KEGG pathway for CD7 Gene
1 R&D Systems pathway for CD7 Gene

Gene Ontology (GO) - Biological Process for CD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0042110 T cell activation TAS 11485208
genes like me logo Genes that share ontologies with CD7: view

No data available for SIGNOR curated interactions for CD7 Gene

Drugs & Compounds for CD7 Gene

No Compound Related Data Available

Transcripts for CD7 Gene

Unigene Clusters for CD7 Gene

CD7 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5:
SP6: - -

Relevant External Links for CD7 Gene

GeneLoc Exon Structure for
CD7
ECgene alternative splicing isoforms for
CD7

Expression for CD7 Gene

mRNA expression in normal human tissues for CD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD7 Gene

This gene is overexpressed in Whole Blood (x31.4) and Spleen (x6.1).

Protein differential expression in normal tissues from HIPED for CD7 Gene

This gene is overexpressed in NK cells (22.6), Urine (18.1), CD8 Tcells (11.5), and Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CD7 Gene



SOURCE GeneReport for Unigene cluster for CD7 Gene Hs.36972

genes like me logo Genes that share expression patterns with CD7: view

Protein tissue co-expression partners for CD7 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CD7 Gene

Orthologs for CD7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD7 35
  • 70.92 (n)
  • 59.04 (a)
CD7 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD7 35
  • 70.99 (n)
  • 55.14 (a)
CD7 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd7 35
  • 68.59 (n)
  • 52.88 (a)
Cd7 16
Cd7 36
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD7 35
  • 98.02 (n)
  • 96.8 (a)
CD7 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd7 35
  • 67.89 (n)
  • 51.83 (a)
oppossum
(Monodelphis domestica)
Mammalia CD7 36
  • 35 (a)
OneToOne
Species with no ortholog for CD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD7 Gene

ENSEMBL:
Gene Tree for CD7 (if available)
TreeFam:
Gene Tree for CD7 (if available)

Paralogs for CD7 Gene

(1) SIMAP similar genes for CD7 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CD7: view

No data available for Paralogs for CD7 Gene

Variants for CD7 Gene

Sequence variations from dbSNP and Humsavar for CD7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34579511 - 82,316,727(+) GCAGG(C/G/T)GTAGG reference, missense
rs1129410 -- 82,315,204(-) AGAGT(A/T)TGAAG utr-variant-3-prime
rs3176829 -- 82,317,377(-) GCTCC(A/G)GAGCT intron-variant
rs3176830 -- 82,316,567(-) ATGTG(C/T)CTGAA intron-variant
rs3176831 -- 82,314,615(-) CCCCC(A/G)ACCCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CD7 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3332n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3341n71 CNV Loss 21882294
dgv3353n71 CNV Loss 21882294
dgv3354n71 CNV Loss 21882294
nsv833572 CNV Loss 17160897
dgv3355n71 CNV Loss 21882294
nsv909208 CNV Loss 21882294
nsv469561 CNV Complex 16826518
dgv3356n71 CNV Loss 21882294
nsv909217 CNV Loss 21882294
nsv833573 CNV Loss 17160897
dgv3357n71 CNV Loss 21882294

Variation tolerance for CD7 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CD7 Gene

Disorders for CD7 Gene

MalaCards: The human disease database

(21) MalaCards diseases for CD7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
pityriasis lichenoides et varioliformis acuta
  • mucha-habermann disease
mycosis fungoides
  • mf
pityriasis lichenoides
acute t cell leukemia
  • precursor t lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search CD7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD7

Human Genome Epidemiology (HuGE) Navigator
CD7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD7
genes like me logo Genes that share disorders with CD7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD7 Gene

Publications for CD7 Gene

  1. Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. (PMID: 3501369) Aruffo A. … Seed B. (EMBO J. 1987) 2 3 4 67
  2. Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker. (PMID: 20046078) Yoo E.H. … Kim S.H. (Korean J Lab Med 2009) 3 23
  3. CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia. (PMID: 16332967) Bremer E. … Helfrich W. (Blood 2006) 3 23
  4. Role of CD7 expressed in lung microvascular endothelial cells as Fc receptor for immunoglobulin M. (PMID: 16990185) Nishimura M. … Nakajima K. (Endothelium 2006) 3 23
  5. Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover. (PMID: 12594831) Subrahmanyam G. … Schneider H. (Eur. J. Immunol. 2003) 3 23

Products for CD7 Gene

Sources for CD7 Gene

Content