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Aliases for CD69 Gene

Aliases for CD69 Gene

  • CD69 Molecule 2 3
  • CD69 Antigen (P60, Early T-Cell Activation Antigen) 2 3
  • Early T-Cell Activation Antigen P60 3 4
  • Leukocyte Surface Antigen Leu-23 3 4
  • BL-AC/P26 3 4
  • GP32/28 3 4
  • CLEC2C 3 4
  • MLR-3 3 4
  • AIM 3 4
  • EA1 3 4
  • C-Type Lectin Domain Family 2, Member C 3
  • Activation Inducer Molecule (AIM/CD69) 3
  • C-Type Lectin Domain Family 2 Member C 4
  • Early Lymphocyte Activation Antigen 3
  • Early Activation Antigen CD69 3
  • Activation Inducer Molecule 4
  • CD69 Antigen 4

External Ids for CD69 Gene

Summaries for CD69 Gene

Entrez Gene Summary for CD69 Gene

  • This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD69 Gene

CD69 (CD69 Molecule) is a Protein Coding gene. Diseases associated with CD69 include mast cell disease and coccidioidomycosis. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is CLEC2A.

UniProtKB/Swiss-Prot for CD69 Gene

  • Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets

Gene Wiki entry for CD69 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD69 Gene

Genomics for CD69 Gene

Genomic Location for CD69 Gene

Start:
9,752,486 bp from pter
End:
9,760,901 bp from pter
Size:
8,416 bases
Orientation:
Minus strand

Genomic View for CD69 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD69 Gene

Regulatory Elements for CD69 Gene

Proteins for CD69 Gene

  • Protein details for CD69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07108-CD69_HUMAN
    Recommended name:
    Early activation antigen CD69
    Protein Accession:
    Q07108
    Secondary Accessions:

    Protein attributes for CD69 Gene

    Size:
    199 amino acids
    Molecular mass:
    22559 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CD69 Gene

neXtProt entry for CD69 Gene

Proteomics data for CD69 Gene at MOPED

Post-translational modifications for CD69 Gene

  • Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn166

Other Protein References for CD69 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD69 Gene

Domains for CD69 Gene

Gene Families for CD69 Gene

HGNC:
  • CD :CD molecules
  • CLEC :C-type lectin domain containing

Protein Domains for CD69 Gene

UniProtKB/Swiss-Prot:

CD69_HUMAN
Domain:
  • Contains 1 C-type lectin domain.:
    • Q07108
genes like me logo Genes that share domains with CD69: view

Function for CD69 Gene

Molecular function for CD69 Gene

GENATLAS Biochemistry: cell differentiation antigen CD69,60kDa homodimer,membrane glycoprotein,in the NK (natural killer) complex,identified by monoclonal antibody C1.18,expressed in NK and many other hemopoietic cells
UniProtKB/Swiss-Prot Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets
UniProtKB/Swiss-Prot Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells

Gene Ontology (GO) - Molecular Function for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 8340758
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CD69: view
genes like me logo Genes that share phenotypes with CD69: view

Animal Models for CD69 Gene

MGI Knock Outs for CD69:

miRNA for CD69 Gene

miRTarBase miRNAs that target CD69

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD69 Gene

Localization for CD69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD69 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD69 Gene COMPARTMENTS Subcellular localization image for CD69 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8340758
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CD69: view

Pathways for CD69 Gene

SuperPathways for CD69 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8340758
GO:0035690 cellular response to drug IEA --
genes like me logo Genes that share ontologies with CD69: view

No data available for Pathways by source for CD69 Gene

Compounds for CD69 Gene

(44) Novoseek inferred chemical compound relationships for CD69 Gene

Compound -log(P) Hits PubMed IDs
ionomycin 67.8 17
tyrosine 37.8 16
thymidine 36.7 16
phorbol 32 4
con a 29.1 2
genes like me logo Genes that share compounds with CD69: view

Transcripts for CD69 Gene

Unigene Clusters for CD69 Gene

CD69 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD69 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CD69 Gene

GeneLoc Exon Structure for
CD69
ECgene alternative splicing isoforms for
CD69

Expression for CD69 Gene

mRNA expression in normal human tissues for CD69 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD69 Gene

This gene is overexpressed in Whole Blood (6.4) and Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CD69 Gene

SOURCE GeneReport for Unigene cluster for CD69 Gene Hs.208854

mRNA Expression by UniProt/SwissProt for CD69 Gene

Q07108-CD69_HUMAN
Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets
genes like me logo Genes that share expressions with CD69: view

Orthologs for CD69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD69 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD69 36
  • 99.66 (n)
  • 99.5 (a)
CD69 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD69 36
  • 78.06 (n)
  • 62.31 (a)
CD69 37
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD69 36
  • 80.23 (n)
  • 65.83 (a)
CD69 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd69 36
  • 70.52 (n)
  • 57.79 (a)
Cd69 16
Cd69 37
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD69 37
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD69 37
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd69 36
  • 70.73 (n)
  • 59.9 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 28 (a)
OneToMany
-- 37
  • 18 (a)
OneToMany
-- 37
  • 31 (a)
OneToMany
-- 37
  • 26 (a)
OneToMany
-- 37
  • 18 (a)
OneToMany
-- 37
  • 29 (a)
OneToMany
-- 37
  • 33 (a)
OneToMany
-- 37
  • 30 (a)
OneToMany
-- 37
  • 31 (a)
OneToMany
-- 37
  • 20 (a)
OneToMany
-- 37
  • 21 (a)
OneToMany
17.5 37
  • 27 (a)
OneToMany
BLEC1 37
  • 32 (a)
OneToMany
LOC769354 36
  • 54.69 (n)
  • 43.75 (a)
Y-LEC1 37
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 33 (a)
OneToMany
-- 37
  • 24 (a)
OneToMany
-- 37
  • 45 (a)
OneToMany
-- 37
  • 29 (a)
OneToMany
-- 37
  • 26 (a)
OneToMany
-- 37
  • 28 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 32 (a)
OneToMany
-- 37
  • 46 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
-- 37
  • 27 (a)
OneToMany
Species with no ortholog for CD69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD69 Gene

ENSEMBL:
Gene Tree for CD69 (if available)
TreeFam:
Gene Tree for CD69 (if available)

Paralogs for CD69 Gene

Paralogs for CD69 Gene

Selected SIMAP similar genes for CD69 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD69: view

Variants for CD69 Gene

Sequence variations from dbSNP and Humsavar for CD69 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs704223 -- 9,752,962(-) TGAAA(C/T)TAAGA utr-variant-3-prime
rs725943 -- 9,760,854(+) TCAGG(A/T)CAAGT utr-variant-5-prime
rs766501 -- 9,755,789(+) TGGTA(C/T)AGCTG intron-variant
rs766502 -- 9,755,833(+) TGGGA(A/G)CTTTT intron-variant
rs887901 -- 9,752,400(-) CTTAG(A/G)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CD69 Gene

Variant ID Type Subtype PubMed ID
dgv466e1 CNV Complex 17122850
dgv468e1 CNV Complex 17122850

Relevant External Links for CD69 Gene

HapMap Linkage Disequilibrium report
CD69

Disorders for CD69 Gene

(59) Novoseek inferred disease relationships for CD69 Gene

Disease -log(P) Hits PubMed IDs
necrosis 40.1 17
rheumatoid arthritis 34.5 10
autoimmune diseases 33.3 1
leukemia b-cell 31.9 1
asthma allergic 30.5 1

Relevant External Links for CD69

Genetic Association Database (GAD)
CD69
Human Genome Epidemiology (HuGE) Navigator
CD69
genes like me logo Genes that share disorders with CD69: view

No data available for UniProtKB/Swiss-Prot for CD69 Gene

Publications for CD69 Gene

  1. Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. (PMID: 1612643) Cambiaggi C. … Accolla R.S. (Immunogenetics 1992) 2 3 23
  2. Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. (PMID: 11101293) Natarajan K. … Mariuzza R.A. (Biochemistry 2000) 3 4 23
  3. Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. (PMID: 8100776) Ziegler S.F. … Alderson M.R. (Eur. J. Immunol. 1993) 3 4 23
  4. Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. (PMID: 8340758) Lopez-Cabrera M. … Sanchez-Madrid F. (J. Exp. Med. 1993) 3 4 23
  5. Bcl-2-mediated regulation of CD69-induced apoptosis of human eosinophils: identification and characterization of a novel receptor-induced mechanism and relationship to CD95-transduced signalling. (PMID: 12234263) Foerster M. … Kroegel C. (Scand. J. Immunol. 2002) 3 23

Products for CD69 Gene

Sources for CD69 Gene

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