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Aliases for CD69 Gene

Aliases for CD69 Gene

  • CD69 Molecule 2 3 5
  • CD69 Antigen (P60, Early T-Cell Activation Antigen) 2 3
  • Early T-Cell Activation Antigen P60 3 4
  • Leukocyte Surface Antigen Leu-23 3 4
  • BL-AC/P26 3 4
  • GP32/28 3 4
  • CLEC2C 3 4
  • MLR-3 3 4
  • AIM 3 4
  • EA1 3 4
  • C-Type Lectin Domain Family 2, Member C 3
  • Activation Inducer Molecule (AIM/CD69) 3
  • C-Type Lectin Domain Family 2 Member C 4
  • Early Lymphocyte Activation Antigen 3
  • Early Activation Antigen CD69 3
  • Activation Inducer Molecule 4
  • CD69 Antigen 4

External Ids for CD69 Gene

Previous GeneCards Identifiers for CD69 Gene

  • GC12M009587
  • GC12M010027
  • GC12M009805
  • GC12M009796
  • GC12M009907
  • GC12M009648
  • GC12M009908
  • GC12M010062
  • GC12M010256
  • GC12M010498
  • GC12M009811
  • GC12M010321
  • GC12M010760
  • GC12M010993

Summaries for CD69 Gene

Entrez Gene Summary for CD69 Gene

  • This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD69 Gene

CD69 (CD69 Molecule) is a Protein Coding gene. Diseases associated with CD69 include Coccidioidomycosis and Asthma. Among its related pathways are Kit Receptor Signaling Pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include calcium ion binding and carbohydrate binding. An important paralog of this gene is CLEC2A.

UniProtKB/Swiss-Prot for CD69 Gene

  • Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

Gene Wiki entry for CD69 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD69 Gene

Genomics for CD69 Gene

Regulatory Elements for CD69 Gene

Enhancers for CD69 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F009792 1.6 FANTOM5 Ensembl ENCODE 16.5 -34.7 -34741 6.3 PKNOX1 TBL1XR1 ARNT WRNIP1 RAD21 RFX5 CBX5 SCRT2 ZNF143 RCOR1 CD69 CLEC7A LOC728715 CLEC2B OLR1 LOC100419929 LOC105369653
GH12F009736 1.4 FANTOM5 Ensembl ENCODE 11.3 +20.9 20879 7.6 PKNOX1 GATA2 CBX5 ZNF143 JUNB TBX21 MEF2D SMARCA4 HMBOX1 STAT3 CLECL1 CLEC2D KLRB1 ENSG00000213443 ENSG00000214776 CD69 CLEC7A ENSG00000257027 CLEC2B KLRF1
GH12F009614 0.8 FANTOM5 Ensembl ENCODE 10.5 +144.4 144393 3.3 PKNOX1 MTA2 SCRT2 NBN TBX21 MAFK SPI1 CLEC2D KLRB1 KLRF1 ENSG00000214776 ENSG00000257027 CD69 CLECL1 LOC374443 CLEC2B
GH12F009646 1.4 FANTOM5 ENCODE 9.1 +109.2 109168 10.0 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 SLC30A9 CBX5 SP3 SP5 CLEC2D LOC374443 KLRB1 CLECL1 CLEC12A ENSG00000214776 PHC1 CD69 CLEC7A DDX12P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CD69 on UCSC Golden Path with GeneCards custom track

Promoters for CD69 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001774846 1501 4401 TBP PKNOX1 CBX3 TBL1XR1 WRNIP1 ZBTB40 EGR1 CBX5 SCRT2 ZNF143

Genomic Location for CD69 Gene

9,752,486 bp from pter
9,760,901 bp from pter
8,416 bases
Minus strand

Genomic View for CD69 Gene

Genes around CD69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD69 Gene

Proteins for CD69 Gene

  • Protein details for CD69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Early activation antigen CD69
    Protein Accession:

    Protein attributes for CD69 Gene

    199 amino acids
    Molecular mass:
    22559 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CD69 Gene

neXtProt entry for CD69 Gene

Post-translational modifications for CD69 Gene

  • Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.
  • Glycosylation at Asn 166
  • Modification sites at PhosphoSitePlus

Other Protein References for CD69 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD69 Gene

Domains & Families for CD69 Gene

Gene Families for CD69 Gene

Protein Domains for CD69 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CD69: view

Function for CD69 Gene

Molecular function for CD69 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD69,60kDa homodimer,membrane glycoprotein,in the NK (natural killer) complex,identified by monoclonal antibody C1.18,expressed in NK and many other hemopoietic cells
UniProtKB/Swiss-Prot Function:
Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
UniProtKB/Swiss-Prot Induction:
By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells.

Gene Ontology (GO) - Molecular Function for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 8340758
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CD69: view
genes like me logo Genes that share phenotypes with CD69: view

Animal Models for CD69 Gene

MGI Knock Outs for CD69:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD69 Gene

Localization for CD69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD69 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for CD69 Gene COMPARTMENTS Subcellular localization image for CD69 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
nucleus 2
cytoskeleton 1
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8340758
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD69: view

Pathways & Interactions for CD69 Gene

genes like me logo Genes that share pathways with CD69: view

Pathways by source for CD69 Gene

SIGNOR curated interactions for CD69 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0035690 cellular response to drug IEA --
genes like me logo Genes that share ontologies with CD69: view

Drugs & Compounds for CD69 Gene

(24) Drugs for CD69 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tocilizumab Approved Pharma Immunotherapies 0

(21) Additional Compounds for CD69 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD69: view

Transcripts for CD69 Gene

Unigene Clusters for CD69 Gene

CD69 molecule:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD69 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for CD69 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD69 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD69 Gene

This gene is overexpressed in Whole Blood (x6.4) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for CD69 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (57.6) and Platelet (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD69 Gene

Protein tissue co-expression partners for CD69 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD69 Gene:


SOURCE GeneReport for Unigene cluster for CD69 Gene:


mRNA Expression by UniProt/SwissProt for CD69 Gene:

Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.
genes like me logo Genes that share expression patterns with CD69: view

Primer Products

Orthologs for CD69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD69 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD69 34 35
  • 99.66 (n)
(Canis familiaris)
Mammalia CD69 34 35
  • 80.23 (n)
(Bos Taurus)
Mammalia CD69 34 35
  • 78.06 (n)
(Rattus norvegicus)
Mammalia Cd69 34
  • 70.73 (n)
(Mus musculus)
Mammalia Cd69 34 16 35
  • 70.52 (n)
(Monodelphis domestica)
Mammalia CD69 35
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia CD69 35
  • 33 (a)
(Gallus gallus)
Aves LOC769354 34
  • 54.69 (n)
-- 35
  • 33 (a)
BLEC1 35
  • 32 (a)
-- 35
  • 31 (a)
-- 35
  • 31 (a)
Y-LEC1 35
  • 31 (a)
-- 35
  • 30 (a)
-- 35
  • 29 (a)
-- 35
  • 28 (a)
17.5 35
  • 27 (a)
-- 35
  • 26 (a)
-- 35
  • 21 (a)
-- 35
  • 20 (a)
-- 35
  • 18 (a)
-- 35
  • 18 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
-- 35
  • 45 (a)
-- 35
  • 37 (a)
-- 35
  • 35 (a)
-- 35
  • 33 (a)
-- 35
  • 32 (a)
-- 35
  • 29 (a)
-- 35
  • 28 (a)
-- 35
  • 27 (a)
-- 35
  • 26 (a)
-- 35
  • 24 (a)
Species where no ortholog for CD69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD69 Gene

Gene Tree for CD69 (if available)
Gene Tree for CD69 (if available)

Paralogs for CD69 Gene

Paralogs for CD69 Gene

(6) SIMAP similar genes for CD69 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD69: view

Variants for CD69 Gene

Sequence variations from dbSNP and Humsavar for CD69 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1051065 -- 9,753,471(-) GAAAC(A/G)TGTTC utr-variant-3-prime
rs10548264 -- 9,760,005(+) TAAGT(-/TACA)TAGTC intron-variant
rs10638424 -- 9,752,414(+) AGTAA(-/CT)CTGTT downstream-variant-500B
rs10772119 -- 9,757,683(+) TTGCA(C/T)TTACA intron-variant
rs10772120 -- 9,757,815(+) GGAAA(C/G)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD69 Gene

Variant ID Type Subtype PubMed ID
esv2759878 CNV gain+loss 17122850
nsv1051530 CNV gain 25217958
nsv952801 CNV duplication 24416366

Variation tolerance for CD69 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD69 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD69 Gene

Disorders for CD69 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CD69 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • primary extrapulmonary coccidioidomycosis
  • asthma, protection against
  • acute generalized peritonitis
common variable immunodeficiency
  • acquired agammaglobulinemia
mast cell disease
  • urticaria pigmentosa
- elite association - COSMIC cancer census association via MalaCards
Search CD69 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD69

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CD69: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD69 Gene

Publications for CD69 Gene

  1. Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. (PMID: 11101293) Natarajan K. … Mariuzza R.A. (Biochemistry 2000) 3 4 22 64
  2. Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. (PMID: 8100776) Ziegler S.F. … Alderson M.R. (Eur. J. Immunol. 1993) 3 4 22 64
  3. Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. (PMID: 8340758) Lopez-Cabrera M. … Sanchez-Madrid F. (J. Exp. Med. 1993) 3 4 22 64
  4. Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. (PMID: 1612643) Cambiaggi C. … Accolla R.S. (Immunogenetics 1992) 2 3 22 64
  5. In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium. (PMID: 20378605) Qu H.Q. … Polychronakos C. (Hum. Mol. Genet. 2010) 3 46 64

Products for CD69 Gene

Sources for CD69 Gene

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