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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD69 Gene

protein-coding GIFtS: 57
GCID: GC12M010062

CD69 molecule

(Previous names: CD69 antigen (p60, early T-cell activation antigen) )

Explore 84 diseases affiliated with
CD69 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CD69 Molecule¹ ²		MLR-3² ³
CLEC2C¹ ² ³		Activation Inducer Molecule (AIM/CD69)²
CD69 Antigen (P60, Early T-Cell Activation Antigen)¹ ²		C-Type Lectin Domain Family 2, Member C²
Early T-Cell Activation Antigen P60² ³		Early Activation Antigen CD69²
Leukocyte Surface Antigen Leu-23² ³		Early Lymphocyte Activation Antigen²
AIM² ³		Activation Inducer Molecule³
BL-AC/P26² ³		C-Type Lectin Domain Family 2 Member C³
EA1² ³		CD69 Antigen³
GP32/28² ³

External Ids:	HGNC: 1694¹	Entrez Gene: 969²	Ensembl: ENSG00000110848⁷	OMIM: 107273⁵	UniProtKB: Q07108³

ORGUL members:
	NONCODE:n407205 n407206

Export aliases for CD69 gene to outside databases

Previous GC identifers: GC12M009587 GC12M010027 GC12M009805 GC12M009796 GC12M009907 GC12M009648 GC12M009908

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD69:

This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression

of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore,

the protein may act to transmit signals in natural killer cells and platelets. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108

Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural

killer (NK) cells, and platelets

Gene Wiki entry for CD69

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD69 gene promoter:
GR CREB AP-1 deltaCREB c-Jun STAT5A GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD69 promoter sequence

Search SABiosciences Chromatin IP Primers for CD69

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD69

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13

CD69 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD69 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M010062: view genomic region (about GC identifiers)

Start:	9,905,082 bp from pter	End:	9,913,497 bp from pter
Size:	8,416 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108 (See protein sequence)

Recommended Name: Early activation antigen CD69

Size: 199 amino acids; 22559 Da

Subunit: Homodimer; disulfide-linked

Subcellular location: Membrane; Single-pass type II membrane protein

Developmental stage: Earliest inducible cell surface glycoprotein acquired during lymphoid activation

5 PDB 3D structures from and Proteopedia for CD69:

1E87 (3D)

1E8I (3D)

1FM5 (3D)

3CCK (3D)

3HUP (3D)

Explore the universe of human proteins at neXtProt for CD69: NX_Q07108

Post-translational modifications:

Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07108

CD69 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001772.1

ENSEMBL proteins:

ENSP00000228434 ENSP00000442597

Human Recombinant Protein Products for CD69:

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	Novus Biologicals CD69 Proteins Novus Biologicals CD69 Lysates
	Sino Biological Recombinant Protein for CD69
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD69

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	8340758
GO:0009897	external side of plasma membrane	IEA	--

CD69 for ontologies About GeneDecksing

CD69 Antibody Products:

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Assay Products for CD69:

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	GenScript Custom Assay Services for CD69
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD69

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD69 for domains About GeneDecksing

3 InterPro domains/families:

IPR016187 C-type_lectin_fold

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry Q07108

ProtoNet protein and cluster: Q07108

UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108

Similarity: Contains 1 C-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CD69_HUMAN, Q07108

Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural

killer (NK) cells, and platelets

Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2

with the p75 IL-2R on the surface of NK cells

Genatlas biochemistry entry for CD69:

cell differentiation antigen CD69,60kDa homodimer,membrane glycoprotein,in the NK (natural killer) complex,identified

by monoclonal antibody C1.18,expressed in NK and many other hemopoietic cells

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	TAS	8340758
GO:0030246	carbohydrate binding	IEA	--

CD69 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cd69):

cellular

hematopoietic system

immune system

no phenotypic analysis

skeleton

CD69 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CD69: Cd69^tm1Fsm Cd69^tm1Naka

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD69

miRNA Products:		OriGene 3'-UTR Clone: CD69 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD69
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CD69 (see all 43):
		hsa-miR-142-5p hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: CD69 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD69 (see all 7) OriGene shRNA RFP: CD69 OriGene siRNA: CD69
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CD69
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD69 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD69 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD69 (NM_001781)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD69
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD69

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD69

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CD69 (Q07108³ ENSP00000228434⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RELA	Q04206³, ENSP00000384273⁴	I2D: score=1 STRING: ENSP00000384273

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0035690	cellular response to drug	IEA	--

CD69 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD69 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD69
10/44 Novoseek chemical compound relationships for CD69 gene (see all 44) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ionomycin	67.8	18	16274628 (2), 12914753 (1), 8566003 (1), 9682002 (1) (see all 16)
tyrosine	37.8	19	7682535 (2), 8477800 (2), 8103709 (2), 7489748 (1) (see all 13)
thymidine	36.7	17	9188933 (2), 17575216 (1), 18844109 (1), 19255156 (1) (see all 15)
phorbol	32	5	8977272 (1), 8301128 (1), 8977253 (1), 7664776 (1)
con a	29.1	2	1373002 (1), 8979031 (1)
cyclosporin a	27.3	19	11036825 (4), 12385031 (2), 18424069 (1), 8566003 (1) (see all 9)
pd 98,059	23.2	4	15629076 (2), 11238629 (1), 9510155 (1)
calcium	23	37	8566003 (3), 12899616 (3), 7682535 (2), 12841627 (2) (see all 19)
isopentenyl diphosphate	19.3	2	9130649 (2)
poly(i-c)	18.9	2	15634892 (1), 16728430 (1)

Search CenterWatch for drugs/clinical trials and news about CD69

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD69 gene:

NM_001781.2

Unigene Cluster for CD69:

CD69 molecule

Hs.208854 [show with all ESTs]

Unigene Representative Sequence: Z22576

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000228434(uc001qwk.3) ENST00000536709(uc010sgu.2) ENST00000416624(uc010sgv.1)

ENST00000543147

miRNA Products:		OriGene 3'-UTR Clone: CD69 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD69
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CD69 (see all 43):
		hsa-miR-142-5p hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: CD69 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CD69

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD69 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD69 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD69 (NM_001781)
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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CD69
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD69
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD69

Additional cDNA sequence:

AK291869.1 AK303174.1 AK303383.1 AY238518.1 BC007037.1 L07555.1 Z22576.1

6 DOTS entries:

DT.114980 DT.40117198 DT.102825236 DT.99930976 DT.86852294 DT.99931337

24/197 AceView cDNA sequences (see all 197):

CD678130 CD678131 BM955742 CK822697 BM955743 AY238518 CD641540 CD521291

AU185660 CD523414 CD641936 CD559308 BI765177 CD521944 CD102364 BE969926

CD520726 NM_001781 CD639692 CD520808 AA380916 CD521355 CB984792 CD521076

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CD69 About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5
SP1:					-				-
SP2:					-				-		-
SP3:					-
SP4:

ECgene alternative splicing isoforms for CD69

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD69 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CD69 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Peripheral Blood

T-Cytotoxic Cells

Selective marker (cell-identifying gene)

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

See CD69 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD69

SOURCE GeneReport for Unigene cluster: Hs.208854

UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108

Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils,

eosinophils, epidermal Langerhans cells and platelets

SABiosciences Expression via Pathway-Focused PCR Arrays including CD69:

HIV Host Response in human mouse rat

Cell Surface Markers in human mouse rat

NFKB Signaling Targets in human mouse rat

Th1/Th2 Response in human mouse rat

Type I Interferon Response in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD69

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD69 gene from 1/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	--	28(a) 27(a)	many ↔ many many ↔ many	GL343438.1(366685-369578) GL343623.1(161656-164814)

ENSEMBL Gene Tree for CD69 (if available)
TreeFam Gene Tree for CD69 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD69 gene

CLEC2L² CLEC2A² CLEC2B² KLRF2² KLRG2² CLEC2D² CLEC5A² KLRF1²

KLRG1² KLRB1²

6 SIMAP similar genes for CD69 using alignment to 4 protein entries: CD69_HUMAN (see all proteins):

CLEC2A CLEC2D FCER2 CLEC2L KLRD1 CLEC2B

CD69 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3176804^1,2	C,F	--	9904617(-)	`GGAGCG/AAATCT`	1	--	ds500¹		4		NA	164
rs116862827^1,2		--	9904618(+)	`GATTCG/ACTCCC`	1	--	ds500¹		1		EA	120
rs185884792^1,2		--	9904641(+)	`CCTCCA/CACCAG`	1	--	ds500¹		0	--	--	--	--
rs2401398^1,2	C,F,A,H	--	9904679(+)	`ATGCGC/ACATGA`	1	--	ds500¹		12		NS EA NA WA	816
rs3176802^1,2	C,F,O,A,H	--	9904807(-)	`TGCTAC/TATACA`	1	--	ds500¹		27		NA NS EA WA CSA	2818
rs191137192^1,2		--	9904867(+)	`TATTAC/TAGAGC`	1	--	ds500¹		0	--	--	--	--
rs150374990^1,2		--	9904880(+)	`CTGCTA/CTATAC`	1	--	ds500¹		0	--	--	--	--
rs887901^1,2	C,F,H	--	9904996(-)	`CTTAGA/GAAAAA`	1	--	ds500¹		13		NS EA NA WA	792
rs200168164^1,2	C	--	9905008(+)	`TATAGA/TAACTG`	1	--	ds500¹		0	--	--	--	--
rs10638424^1,2	C	--	9905010(+)	`AGTAACT/-CTGTT`	1	--	ds500¹		1		CSA	2

HapMap Linkage Disequilibrium report for CD69 (9905082 - 9913497 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD69
1 CNV: 3874

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD69

DNA2.0 Custom Variant and Variant Library Synthesis for CD69

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD69 for disorders           About GeneDecksing

OMIM gene information: 107273    OMIM disorders: --

20/84 diseases for CD69 (see all 84):    About MalaCards

spinal cord injury b-cell non-hodgkin lymphoma hypersensitivity reaction type ii disease non-hodgkin lymphoma

human immunodeficiency virus infectious disease common variable immunodeficiency toxic shock syndrome intermediate uveitis

aphthous stomatitis coccidioidomycosis lichen sclerosus hypereosinophilic syndrome

spontaneous abortion lupus erythematosus hodgkin's lymphoma chronic fatigue syndrome

eosinophilic pneumonia uveitis mastocytosis systemic lupus erythematosus

4 diseases from the University of Copenhagen DISEASES database for CD69:

Hypersensitivity reaction type II disease Cancer Rheumatoid arthritis Asthma

10/59 Novoseek disease relationships for CD69 gene (see all 59) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	40.1	20	10361243 (1), 11270597 (1), 16751018 (1), 15010848 (1) (see all 17)
rheumatoid arthritis	34.5	10	8702434 (2), 8323399 (2), 10466080 (1), 11036825 (1) (see all 8)
autoimmune diseases	33.3	1	14604548 (1)
leukemia b-cell	31.9	1	12684639 (1)
asthma allergic	30.5	1	10445598 (1)
lymphocytic leukemia chronic b-cell	30.4	1	12684639 (1)
pneumonia eosinophilic	28.7	5	1500624 (2), 8031251 (1)
inflammation	26.4	4	15693863 (1), 10726729 (1), 7664776 (1)
immunodeficiency	26.1	3	9067659 (2), 10516611 (1)
tumors	23	23	20116265 (2), 16332516 (1), 11270597 (1), 1612643 (1) (see all 21)

Human Genome Epidemiology (HuGE) Navigator: CD69 (7 documents)

Export disorders for CD69 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CD69 gene, integrated from 9 sources (see all 560):
(articles sorted by number of sources associating them with CD69)

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Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. (PubMed id 8340758)^{1, 2, 9} Lopez-Cabrera M.... Sanchez-Madrid F. (1993)
Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. (PubMed id 11101293)^{1, 2, 9} Natarajan K.... Mariuzza R.A. (2000)
Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. (PubMed id 8100776)^{1, 2, 9} Ziegler S.F....Alderson M.R. (1993)
Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. (PubMed id 1612643)^{1, 3, 9} Cambiaggi C....Accolla R.S. (1992)
Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice. (PubMed id 18959746)^{1, 2} Vanek O....Bezouska K. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69. (PubMed id 11036086)^{1, 2} Llera A.S.... Tormo J. (2001)
Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors. (PubMed id 8026529)^{1, 2} Santis A.... Sanchez-Madrid F. (1994)
Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain. (PubMed id 8496594)^{1, 2} Hamann J.... Strauss M. (1993)
[Examination expression of CD3 and CD69 in nasal polyps] (PubMed id 15952571)^{1, 9} Shi J.B....Huang G.Q. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 969	HGNC: 1694	AceView: CD69	Ensembl:ENSG00000110848	euGenes: HUgn969
ECgene: CD69	H-InvDB: CD69

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CD69	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD69	Genetics and Cytogenetics in Oncology and Haematology
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_235

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