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Aliases for CD69 Gene

Aliases for CD69 Gene

  • CD69 Molecule 2 3
  • CD69 Antigen (P60, Early T-Cell Activation Antigen) 2 3
  • Early T-Cell Activation Antigen P60 3 4
  • Leukocyte Surface Antigen Leu-23 3 4
  • BL-AC/P26 3 4
  • GP32/28 3 4
  • CLEC2C 3 4
  • MLR-3 3 4
  • AIM 3 4
  • EA1 3 4
  • C-Type Lectin Domain Family 2, Member C 3
  • Activation Inducer Molecule (AIM/CD69) 3
  • C-Type Lectin Domain Family 2 Member C 4
  • Early Lymphocyte Activation Antigen 3
  • Early Activation Antigen CD69 3
  • Activation Inducer Molecule 4
  • CD69 Antigen 4

External Ids for CD69 Gene

Previous GeneCards Identifiers for CD69 Gene

  • GC12M009587
  • GC12M010027
  • GC12M009805
  • GC12M009796
  • GC12M009907
  • GC12M009648
  • GC12M009908
  • GC12M010062
  • GC12M010256
  • GC12M010498

Summaries for CD69 Gene

Entrez Gene Summary for CD69 Gene

  • This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD69 Gene

CD69 (CD69 Molecule) is a Protein Coding gene. Diseases associated with CD69 include mast cell disease and coccidioidomycosis. GO annotations related to this gene include carbohydrate binding and transmembrane signaling receptor activity. An important paralog of this gene is CLEC2A.

UniProtKB/Swiss-Prot for CD69 Gene

  • Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets

Gene Wiki entry for CD69 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD69 Gene

Genomics for CD69 Gene

Regulatory Elements for CD69 Gene

Genomic Location for CD69 Gene

9,752,486 bp from pter
9,760,901 bp from pter
8,416 bases
Minus strand

Genomic View for CD69 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD69 Gene

Proteins for CD69 Gene

  • Protein details for CD69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Early activation antigen CD69
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CD69 Gene

    199 amino acids
    Molecular mass:
    22559 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CD69 Gene

neXtProt entry for CD69 Gene

Proteomics data for CD69 Gene at MOPED

Post-translational modifications for CD69 Gene

  • Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes
  • Glycosylation at Asn166
  • Modification sites at PhosphoSitePlus

Other Protein References for CD69 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD69 Gene

Domains for CD69 Gene

Gene Families for CD69 Gene

  • CD :CD molecules
  • CLEC :C-type lectin domain containing

Protein Domains for CD69 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q07108
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CD69: view

Function for CD69 Gene

Molecular function for CD69 Gene

GENATLAS Biochemistry: cell differentiation antigen CD69,60kDa homodimer,membrane glycoprotein,in the NK (natural killer) complex,identified by monoclonal antibody C1.18,expressed in NK and many other hemopoietic cells
UniProtKB/Swiss-Prot Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets
UniProtKB/Swiss-Prot Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells

Gene Ontology (GO) - Molecular Function for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 8340758
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CD69: view
genes like me logo Genes that share phenotypes with CD69: view

Animal Models for CD69 Gene

MGI Knock Outs for CD69:

miRNA for CD69 Gene

miRTarBase miRNAs that target CD69

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD69 Gene

Localization for CD69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD69 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for CD69 Gene COMPARTMENTS Subcellular localization image for CD69 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8340758
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CD69: view

Pathways for CD69 Gene

SuperPathways for CD69 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8340758
GO:0035690 cellular response to drug IEA --
genes like me logo Genes that share ontologies with CD69: view

No data available for Pathways by source for CD69 Gene

Compounds for CD69 Gene

(44) Novoseek inferred chemical compound relationships for CD69 Gene

Compound -log(P) Hits PubMed IDs
ionomycin 67.8 17
tyrosine 37.8 16
thymidine 36.7 16
phorbol 32 4
con a 29.1 2
genes like me logo Genes that share compounds with CD69: view

Transcripts for CD69 Gene

Unigene Clusters for CD69 Gene

CD69 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD69 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for CD69 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD69 Gene

mRNA expression in normal human tissues for CD69 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD69 Gene

This gene is overexpressed in Whole Blood (6.4) and Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CD69 Gene

SOURCE GeneReport for Unigene cluster for CD69 Gene Hs.208854

mRNA Expression by UniProt/SwissProt for CD69 Gene

Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets
genes like me logo Genes that share expressions with CD69: view

Orthologs for CD69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD69 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD69 35
  • 99.66 (n)
  • 99.5 (a)
CD69 36
  • 99 (a)
(Bos Taurus)
Mammalia CD69 35
  • 78.06 (n)
  • 62.31 (a)
CD69 36
  • 62 (a)
(Canis familiaris)
Mammalia CD69 35
  • 80.23 (n)
  • 65.83 (a)
CD69 36
  • 66 (a)
(Mus musculus)
Mammalia Cd69 35
  • 70.52 (n)
  • 57.79 (a)
Cd69 16
Cd69 36
  • 58 (a)
(Monodelphis domestica)
Mammalia CD69 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia CD69 36
  • 33 (a)
(Rattus norvegicus)
Mammalia Cd69 35
  • 70.73 (n)
  • 59.9 (a)
(Gallus gallus)
Aves -- 36
  • 28 (a)
-- 36
  • 18 (a)
-- 36
  • 31 (a)
-- 36
  • 26 (a)
-- 36
  • 18 (a)
-- 36
  • 29 (a)
-- 36
  • 33 (a)
-- 36
  • 30 (a)
-- 36
  • 31 (a)
-- 36
  • 20 (a)
-- 36
  • 21 (a)
17.5 36
  • 27 (a)
BLEC1 36
  • 32 (a)
LOC769354 35
  • 54.69 (n)
  • 43.75 (a)
Y-LEC1 36
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
-- 36
  • 24 (a)
-- 36
  • 45 (a)
-- 36
  • 29 (a)
-- 36
  • 26 (a)
-- 36
  • 28 (a)
-- 36
  • 35 (a)
-- 36
  • 32 (a)
-- 36
  • 46 (a)
-- 36
  • 37 (a)
-- 36
  • 27 (a)
Species with no ortholog for CD69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD69 Gene

Gene Tree for CD69 (if available)
Gene Tree for CD69 (if available)

Paralogs for CD69 Gene

Paralogs for CD69 Gene

Selected SIMAP similar genes for CD69 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD69: view

Variants for CD69 Gene

Sequence variations from dbSNP and Humsavar for CD69 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs704223 -- 9,752,962(-) TGAAA(C/T)TAAGA utr-variant-3-prime
rs725943 -- 9,760,854(+) TCAGG(A/T)CAAGT utr-variant-5-prime
rs766501 -- 9,755,789(+) TGGTA(C/T)AGCTG intron-variant
rs766502 -- 9,755,833(+) TGGGA(A/G)CTTTT intron-variant
rs887901 -- 9,752,400(-) CTTAG(A/G)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CD69 Gene

Variant ID Type Subtype PubMed ID
dgv466e1 CNV Complex 17122850
dgv468e1 CNV Complex 17122850

Relevant External Links for CD69 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD69 Gene

Disorders for CD69 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for CD69 Gene including...

Search for CD69 Gene in MalaCards »

(59) Novoseek inferred disease relationships for CD69 Gene

Disease -log(P) Hits PubMed IDs
necrosis 40.1 17
rheumatoid arthritis 34.5 10
autoimmune diseases 33.3 1
leukemia b-cell 31.9 1
asthma allergic 30.5 1

Relevant External Links for CD69

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD69: view

No data available for UniProtKB/Swiss-Prot for CD69 Gene

Publications for CD69 Gene

  1. Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. (PMID: 1612643) Cambiaggi C. … Accolla R.S. (Immunogenetics 1992) 2 3 23
  2. Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. (PMID: 11101293) Natarajan K. … Mariuzza R.A. (Biochemistry 2000) 3 4 23
  3. Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. (PMID: 8100776) Ziegler S.F. … Alderson M.R. (Eur. J. Immunol. 1993) 3 4 23
  4. Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. (PMID: 8340758) Lopez-Cabrera M. … Sanchez-Madrid F. (J. Exp. Med. 1993) 3 4 23
  5. Bcl-2-mediated regulation of CD69-induced apoptosis of human eosinophils: identification and characterization of a novel receptor-induced mechanism and relationship to CD95-transduced signalling. (PMID: 12234263) Foerster M. … Kroegel C. (Scand. J. Immunol. 2002) 3 23

Products for CD69 Gene

Sources for CD69 Gene

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