Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD69 Gene

Aliases for CD69 Gene

  • CD69 Molecule 2 3 5
  • CD69 Antigen (P60, Early T-Cell Activation Antigen) 2 3
  • Early T-Cell Activation Antigen P60 3 4
  • Leukocyte Surface Antigen Leu-23 3 4
  • BL-AC/P26 3 4
  • GP32/28 3 4
  • CLEC2C 3 4
  • MLR-3 3 4
  • AIM 3 4
  • EA1 3 4
  • C-Type Lectin Domain Family 2, Member C 3
  • Activation Inducer Molecule (AIM/CD69) 3
  • C-Type Lectin Domain Family 2 Member C 4
  • Early Lymphocyte Activation Antigen 3
  • Activation Inducer Molecule 4
  • CD69 Antigen 4

External Ids for CD69 Gene

Previous GeneCards Identifiers for CD69 Gene

  • GC12M009587
  • GC12M010027
  • GC12M009805
  • GC12M009796
  • GC12M009907
  • GC12M009648
  • GC12M009908
  • GC12M010062
  • GC12M010256
  • GC12M010498
  • GC12M009811
  • GC12M010321

Summaries for CD69 Gene

Entrez Gene Summary for CD69 Gene

  • This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD69 Gene

CD69 (CD69 Molecule) is a Protein Coding gene. Diseases associated with CD69 include Asthma and Chronic Fatigue Syndrome. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and B Cell Development Pathways. GO annotations related to this gene include calcium ion binding and carbohydrate binding. An important paralog of this gene is CLEC2L.

UniProtKB/Swiss-Prot for CD69 Gene

  • Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

Gene Wiki entry for CD69 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD69 Gene

Genomics for CD69 Gene

Regulatory Elements for CD69 Gene

Enhancers for CD69 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD69 on UCSC Golden Path with GeneCards custom track

Promoters for CD69 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD69 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD69 Gene

9,752,486 bp from pter
9,760,901 bp from pter
8,416 bases
Minus strand

Genomic View for CD69 Gene

Genes around CD69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD69 Gene

Proteins for CD69 Gene

  • Protein details for CD69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Early activation antigen CD69
    Protein Accession:

    Protein attributes for CD69 Gene

    199 amino acids
    Molecular mass:
    22559 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CD69 Gene

neXtProt entry for CD69 Gene

Proteomics data for CD69 Gene at MOPED

Post-translational modifications for CD69 Gene

  • Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.
  • Glycosylation at Asn 166
  • Modification sites at PhosphoSitePlus

Other Protein References for CD69 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD69 Gene

Domains & Families for CD69 Gene

Gene Families for CD69 Gene

Protein Domains for CD69 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CD69: view

Function for CD69 Gene

Molecular function for CD69 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD69,60kDa homodimer,membrane glycoprotein,in the NK (natural killer) complex,identified by monoclonal antibody C1.18,expressed in NK and many other hemopoietic cells
UniProtKB/Swiss-Prot Function:
Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
UniProtKB/Swiss-Prot Induction:
By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells.

Gene Ontology (GO) - Molecular Function for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CD69: view
genes like me logo Genes that share phenotypes with CD69: view

Animal Models for CD69 Gene

MGI Knock Outs for CD69:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD69 Gene

Localization for CD69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD69 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for CD69 Gene COMPARTMENTS Subcellular localization image for CD69 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
nucleus 2
cytoskeleton 1
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CD69 Gene

Pathways & Interactions for CD69 Gene

genes like me logo Genes that share pathways with CD69: view

Pathways by source for CD69 Gene

SIGNOR curated interactions for CD69 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8340758
genes like me logo Genes that share ontologies with CD69: view

Drugs & Compounds for CD69 Gene

(19) Drugs for CD69 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(25) Additional Compounds for CD69 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD69: view

Transcripts for CD69 Gene

Unigene Clusters for CD69 Gene

CD69 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD69 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for CD69 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD69 Gene

mRNA expression in normal human tissues for CD69 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD69 Gene

This gene is overexpressed in Whole Blood (x6.4) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for CD69 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (57.6) and Platelet (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD69 Gene

SOURCE GeneReport for Unigene cluster for CD69 Gene Hs.208854

mRNA Expression by UniProt/SwissProt for CD69 Gene

Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.
genes like me logo Genes that share expression patterns with CD69: view

Protein tissue co-expression partners for CD69 Gene

- Elite partner

Primer Products

Orthologs for CD69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD69 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD69 35
  • 78.06 (n)
  • 62.31 (a)
CD69 36
  • 62 (a)
(Canis familiaris)
Mammalia CD69 35
  • 80.23 (n)
  • 65.83 (a)
CD69 36
  • 66 (a)
(Mus musculus)
Mammalia Cd69 35
  • 70.52 (n)
  • 57.79 (a)
Cd69 16
Cd69 36
  • 58 (a)
(Pan troglodytes)
Mammalia CD69 35
  • 99.66 (n)
  • 99.5 (a)
CD69 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cd69 35
  • 70.73 (n)
  • 59.9 (a)
(Monodelphis domestica)
Mammalia CD69 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia CD69 36
  • 33 (a)
(Gallus gallus)
Aves LOC769354 35
  • 54.69 (n)
  • 43.75 (a)
-- 36
  • 28 (a)
-- 36
  • 18 (a)
-- 36
  • 31 (a)
-- 36
  • 26 (a)
-- 36
  • 18 (a)
-- 36
  • 29 (a)
-- 36
  • 33 (a)
-- 36
  • 30 (a)
-- 36
  • 31 (a)
-- 36
  • 20 (a)
-- 36
  • 21 (a)
17.5 36
  • 27 (a)
BLEC1 36
  • 32 (a)
Y-LEC1 36
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
-- 36
  • 24 (a)
-- 36
  • 45 (a)
-- 36
  • 29 (a)
-- 36
  • 26 (a)
-- 36
  • 28 (a)
-- 36
  • 35 (a)
-- 36
  • 32 (a)
-- 36
  • 46 (a)
-- 36
  • 37 (a)
-- 36
  • 27 (a)
Species with no ortholog for CD69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD69 Gene

Gene Tree for CD69 (if available)
Gene Tree for CD69 (if available)

Paralogs for CD69 Gene

Paralogs for CD69 Gene

(6) SIMAP similar genes for CD69 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD69: view

Variants for CD69 Gene

Sequence variations from dbSNP and Humsavar for CD69 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2071647 -- 9,761,409(-) CTTTC(A/T)AGCTG upstream-variant-2KB
rs2071648 -- 9,761,321(-) CATAG(A/C/G)GGGTG upstream-variant-2KB
rs10844706 -- 9,757,536(+) gtgaa(A/C)aaatt intron-variant
rs2110444 -- 9,759,683(-) ATTTT(C/T)TAAGC intron-variant
rs2110445 -- 9,759,632(-) TACTT(C/T)TCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD69 Gene

Variant ID Type Subtype PubMed ID
dgv466e1 CNV Complex 17122850
dgv468e1 CNV Complex 17122850

Variation tolerance for CD69 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CD69 Gene

Disorders for CD69 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CD69 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • asthma, protection against
chronic fatigue syndrome
  • cfs
mast cell disease
  • mastocytosis
stromal keratitis
common variable immunodeficiency
  • acquired agammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards
Search CD69 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD69

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CD69: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD69 Gene

Publications for CD69 Gene

  1. Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. (PMID: 8340758) Lopez-Cabrera M. … Sanchez-Madrid F. (J. Exp. Med. 1993) 3 4 23 67
  2. Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. (PMID: 1612643) Cambiaggi C. … Accolla R.S. (Immunogenetics 1992) 2 3 23
  3. Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. (PMID: 19543397) Radstake T.R. … Lafyatis R. (PLoS ONE 2009) 3 23
  4. Decreased expression of CD69 in chronic fatigue syndrome in relation to inflammatory markers: evidence for a severe disorder in the early activation of T lymphocytes and natural killer cells. (PMID: 17693977) Mihaylova I. … Maes M. (Neuro Endocrinol. Lett. 2007) 3 23
  5. [Examination expression of CD3 and CD69 in nasal polyps]. (PMID: 15952571) Shi J.B. … Huang G.Q. (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2005) 3 23

Products for CD69 Gene

Sources for CD69 Gene