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CD69 Gene

protein-coding   GIFtS: 59
GCID: GC12M010498

CD69 Molecule

(Previous names: CD69 antigen (p60, early T-cell activation antigen))
  See CD69-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CD69 Molecule1 2     MLR-32 3
CD69 Antigen (P60, Early T-Cell Activation Antigen)1 2     Activation Inducer Molecule (AIM/CD69)2
Early T-Cell Activation Antigen P602 3     C-Type Lectin Domain Family 2, Member C2
Leukocyte Surface Antigen Leu-232 3     Early Activation Antigen CD692
AIM2 3     Early Lymphocyte Activation Antigen2
BL-AC/P262 3     Activation Inducer Molecule3
CLEC2C2 3     C-Type Lectin Domain Family 2 Member C3
EA12 3     CD69 Antigen3
GP32/282 3     

External Ids:    HGNC: 16941   Entrez Gene: 9692   Ensembl: ENSG000001108487   OMIM: 1072735   UniProtKB: Q071083   
ORGUL members:         

Export aliases for CD69 gene to outside databases

Previous GC identifers: GC12M009587 GC12M010027 GC12M009805 GC12M009796 GC12M009907 GC12M009648 GC12M009908 GC12M010062 GC12M010256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD69 Gene:
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors.
Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in
proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets.
(provided by RefSeq, Aug 2011)

GeneCards Summary for CD69 Gene:
CD69 (CD69 molecule) is a protein-coding gene. Diseases associated with CD69 include coccidioidomycosis, and intermediate uveitis. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC2D.

UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108
Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes,
natural killer (NK) cells, and platelets

Gene Wiki entry for CD69 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD69 gene promoter:
         GR   CREB   AP-1   deltaCREB   c-Jun   STAT5A   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD69 promoter sequence
   Search Chromatin IP Primers for CD69

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD69


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

CD69 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD69 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010498:  view genomic region     (about GC identifiers)

Start:
9,905,082 bp from pter      End:
9,913,497 bp from pter
Size:
8,416 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CD69

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108 (See protein sequence)
Recommended Name: Early activation antigen CD69  
Size: 199 amino acids; 22559 Da
Subunit: Homodimer; disulfide-linked
Developmental stage: Earliest inducible cell surface glycoprotein acquired during lymphoid activation
5 PDB 3D structures from and Proteopedia for CD69:
1E87 (3D)        1E8I (3D)        1FM5 (3D)        3CCK (3D)        3HUP (3D)    

Explore the universe of human proteins at neXtProt for CD69: NX_Q07108

Explore proteomics data for CD69 at MOPED

Post-translational modifications: 

  • Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes1
  • Glycosylation2 at Asn166
  • Modification sites at PhosphoSitePlus

  • See CD69 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001772.1  
    ENSEMBL proteins: 
     ENSP00000228434   ENSP00000442597  

    CD69 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CD69
    Sino Biological Cell Lysate for CD69
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD69 

    CD69 Antibody Products:

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    CD69 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for CD69 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q07108

    ProtoNet protein and cluster: Q07108

    UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with CD69           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD69_HUMAN, Q07108
    Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes,
    natural killer (NK) cells, and platelets
    Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of
    IL-2 with the p75 IL-2R on the surface of NK cells

         Genatlas biochemistry entry for CD69:
    cell differentiation antigen CD69,60kDa homodimer,membrane glycoprotein,in the NK (natural killer)
    complex,identified by monoclonal antibody C1.18,expressed in NK and many other hemopoietic cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS8340758
    GO:0005509calcium ion binding IEA--
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with CD69           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd69):
     cellular  hematopoietic system  immune system  no phenotypic analysis  skeleton 

    Find genes that share phenotypes with CD69           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD69: Cd69tm1Fsm Cd69tm1Naka

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD69
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD69

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD69
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD69

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD69:
    hsa-mir-335-5p (MIRT016695)

    Block miRNA regulation of human, mouse, rat CD69 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD69 (see all 43):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCD69 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD69

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CD69 (NM_001781)
    Sino Biological Human cDNA Clone for CD69
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    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD69


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD69_HUMAN, Q07108: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    nucleus2
    cytoskeleton1
    cytosol1
    lysosome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS8340758
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with CD69           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD69: 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Th1/Th2 Response in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD69

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CD69 (Q071083 ENSP000002284344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8340758
    GO:0035690cellular response to drug IEA--

    Find genes that share ontologies with CD69           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD69

    Selected Novoseek inferred chemical compound relationships for CD69 gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionomycin 67.8 18 16274628 (2), 12914753 (1), 8566003 (1), 9682002 (1) (see all 16)
    tyrosine 37.8 19 7682535 (2), 8477800 (2), 8103709 (2), 7489748 (1) (see all 13)
    thymidine 36.7 17 9188933 (2), 17575216 (1), 18844109 (1), 19255156 (1) (see all 15)
    phorbol 32 5 8977272 (1), 8301128 (1), 8977253 (1), 7664776 (1)
    con a 29.1 2 1373002 (1), 8979031 (1)
    cyclosporin a 27.3 19 11036825 (4), 12385031 (2), 18424069 (1), 8566003 (1) (see all 9)
    pd 98,059 23.2 4 15629076 (2), 11238629 (1), 9510155 (1)
    calcium 23 37 8566003 (3), 12899616 (3), 7682535 (2), 12841627 (2) (see all 19)
    isopentenyl diphosphate 19.3 2 9130649 (2)
    poly(i-c) 18.9 2 15634892 (1), 16728430 (1)



    Find genes that share compounds with CD69           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD69 gene: 
    NM_001781.2  

    Unigene Cluster for CD69:

    CD69 molecule
    Hs.208854  [show with all ESTs]
    Unigene Representative Sequence: Z22576
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228434(uc001qwk.3) ENST00000536709(uc010sgu.2) ENST00000416624(uc010sgv.1)
    ENST00000543147
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD69 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD69 (see all 43):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCD69 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CD69 (NM_001781)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CD69
      QuantiFast Probe-based Assays in human, mouse, rat CD69

    Additional mRNA sequence: 

    AK291869.1 AK303174.1 AK303383.1 AY238518.1 BC007037.1 L07555.1 Z22576.1 

    6 DOTS entries:

    DT.114980  DT.40117198  DT.102825236  DT.99930976  DT.86852294  DT.99931337 

    Selected AceView cDNA sequences (see all 197):

    CK822697 BM955742 CD678131 AY238518 BM955743 CD678130 BG536370 BM543832 
    AI719766 CD639692 CD520770 CD520808 CD520551 CD642031 CD520776 CD521944 
    CD559214 CD521329 CB984792 CD521291 CA772173 CD102364 BG287733 BG498733 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD69    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5
    SP1:              -           -                     
    SP2:              -           -     -               
    SP3:              -                                 
    SP4:                                                


    ECgene alternative splicing isoforms for CD69

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD69 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD69 Expression
    About this image


    CD69 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T-Cytotoxic Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CD69 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD69 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.208854

    UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108
    Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils,
    eosinophils, epidermal Langerhans cells and platelets

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD69: 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Th1/Th2 Response in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD69
    OriGene qSTAR qPCR primer pairs in human, mouse for CD69
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    QuantiFast Probe-based Assays in human, mouse, rat CD69
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD69

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD69 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd691 , 5 CD69 antigen1, 5 70.52(n)1
    57.79(a)1
      6 (63.21 cM)5
    125151  NM_001033122.31  NP_001028294.11 
     1292673255 
    chicken
    (Gallus gallus)
    Aves LOC7693541 C-type lectin domain family 2 member B-like 54.69(n)
    43.75(a)
      769354  XM_001231742.3  XP_001231743.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 11)
    Uncharacterized protein
    (see all 11)
    46(a)
    45(a)
    (see all 11)
    1 ↔ many
    1 ↔ many
    (see all 11)
    GL344089.1(7089-12704)
    GL343316.1(18858-20940)


    ENSEMBL Gene Tree for CD69 (if available)
    TreeFam Gene Tree for CD69 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD69 gene
    CLEC2D2  CLEC2L2  CLEC2A2  CLEC2B2  
    6 SIMAP similar genes for CD69 using alignment to 4 protein entries:     CD69_HUMAN (see all proteins):
    CLEC2A    CLEC2D    FCER2    CLEC2L    KLRD1    CLEC2B

    Find genes that share paralogs with CD69           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD69 (see all 268)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31768041,2
    C,F--9904617(-) GGAGCG/AAATCT 1 -- ds50014Minor allele frequency- A:0.12NA 164
    rs1168628271,2
    C,F--9904618(+) GATTCG/ACTCCC 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1858847921,2
    --9904641(+) CCTCCA/CACCAG 1 -- ds50010--------
    rs24013981,2
    C,F,A,H--9904679(+) ATGCGC/ACATGA 1 -- ds500112Minor allele frequency- A:0.31NS EA NA WA 816
    rs31768021,2
    C,F,O,A,H--9904807(-) TGCTAC/TATACA 1 -- ds500127Minor allele frequency- T:0.17NA NS EA WA CSA 2818
    rs1911371921,2
    --9904867(+) TATTAC/TAGAGC 1 -- ds50010--------
    rs1503749901,2
    --9904880(+) CTGCTA/CTATAC 1 -- ds50010--------
    rs8879011,2
    C,F,H--9904996(-) CTTAGA/GAAAAA 1 -- ds500113Minor allele frequency- G:0.09NS EA NA WA 792
    rs2001681641,2
    C--9905008(+) TATAGA/TAACTG 1 -- ds50010--------
    rs3744551721,2
    C--9905011(+) GTAAC-/CTTGTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CD69 (9905082 - 9913497 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD69:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv466e1CNV Complex17122850
    dgv468e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD69
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107273    OMIM disorders: --

    3 diseases for CD69:    
    About MalaCards
    coccidioidomycosis    intermediate uveitis    stromal keratitis

    6 diseases from the University of Copenhagen DISEASES database for CD69:
    Hypersensitivity reaction type II disease     Cancer     Rheumatoid arthritis     Human immunodeficiency virus infectious disease
    Asthma     Connective tissue disease

    Find genes that share disorders with CD69           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD69 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 40.1 20 10361243 (1), 11270597 (1), 16751018 (1), 15010848 (1) (see all 17)
    rheumatoid arthritis 34.5 10 8702434 (2), 8323399 (2), 10466080 (1), 11036825 (1) (see all 8)
    autoimmune diseases 33.3 1 14604548 (1)
    leukemia b-cell 31.9 1 12684639 (1)
    asthma allergic 30.5 1 10445598 (1)
    lymphocytic leukemia chronic b-cell 30.4 1 12684639 (1)
    pneumonia eosinophilic 28.7 5 1500624 (2), 8031251 (1)
    inflammation 26.4 4 15693863 (1), 10726729 (1), 7664776 (1)
    immunodeficiency 26.1 3 9067659 (2), 10516611 (1)
    tumors 23 23 20116265 (2), 16332516 (1), 11270597 (1), 1612643 (1) (see all 21)

    Genetic Association Database (GAD): CD69
    Human Genome Epidemiology (HuGE) Navigator: CD69 (7 documents)

    Export disorders for CD69 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD69 gene, integrated from 10 sources (see all 565):
    (articles sorted by number of sources associating them with CD69)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. (PubMed id 8340758)1, 2, 9 Lopez-Cabrera M.... Sanchez-Madrid F. (J. Exp. Med. 1993)
    2. Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. (PubMed id 11101293)1, 2, 9 Natarajan K.... Mariuzza R.A. (Biochemistry 2000)
    3. Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. (PubMed id 8100776)1, 2, 9 Ziegler S.F....Alderson M.R. (Eur. J. Immunol. 1993)
    4. Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. (PubMed id 1612643)1, 3, 9 Cambiaggi C....Accolla R.S. (Immunogenetics 1992)
    5. In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium. (PubMed id 20378605)1, 4 Qu H.Q....Polychronakos C. (Hum. Mol. Genet. 2010)
    6. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (Nat. Genet. 2009)
    7. Investigation of CD69 as a new candidate gene for rheumatoid arthritis. (PubMed id 18627570)1, 4 Rueda B....Martin J. (Tissue Antigens 2008)
    8. Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice. (PubMed id 18959746)1, 2 Vanek O.... Bezouska K. (FEBS J. 2008)
    9. Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency. (PubMed id 18593762)1, 4 Skinningsrud B....Undlien D.E. (J. Clin. Endocrinol. Metab. 2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 969 HGNC: 1694 AceView: CD69 Ensembl:ENSG00000110848 euGenes: HUgn969
    ECgene: CD69 H-InvDB: CD69

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CD69 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD69 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_235

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD69 gene:
    Search GeneIP for patents involving CD69

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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