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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD69 Gene

protein-coding   GIFtS: 58
GCID: GC12M010256

CD69 Molecule

(Previous names: CD69 antigen (p60, early T-cell activation antigen))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CD69 Molecule1 2     MLR-32 3
CD69 Antigen (P60, Early T-Cell Activation Antigen)1 2     Activation Inducer Molecule (AIM/CD69)2
Early T-Cell Activation Antigen P602 3     C-Type Lectin Domain Family 2, Member C2
Leukocyte Surface Antigen Leu-232 3     Early Activation Antigen CD692
AIM2 3     Early Lymphocyte Activation Antigen2
BL-AC/P262 3     Activation Inducer Molecule3
CLEC2C2 3     C-Type Lectin Domain Family 2 Member C3
EA12 3     CD69 Antigen3
GP32/282 3     

External Ids:    HGNC: 16941   Entrez Gene: 9692   Ensembl: ENSG000001108487   OMIM: 1072735   UniProtKB: Q071083   
ORGUL members:         
NONCODE14:n407206 n407205      

Export aliases for CD69 gene to outside databases

Previous GC identifers: GC12M009587 GC12M010027 GC12M009805 GC12M009796 GC12M009907 GC12M009648 GC12M009908 GC12M010062


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD69 Gene:
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors.
Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in
proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets.
(provided by RefSeq, Aug 2011)

GeneCards Summary for CD69 Gene: 
CD69 (CD69 molecule) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CD69 include intermediate uveitis, and coccidioidomycosis. GO annotations related to this gene include transmembrane signaling receptor activity and carbohydrate binding. An important paralog of this gene is CLEC2D.

UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108
Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes,
natural killer (NK) cells, and platelets

Gene Wiki entry for CD69 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD69 gene promoter:
         GR   CREB   AP-1   deltaCREB   c-Jun   STAT5A   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD69 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD69

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD69


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

CD69 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD69 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010256:  view genomic region     (about GC identifiers)

Start:
9,905,082 bp from pter      End:
9,913,497 bp from pter
Size:
8,416 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CD69

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108 (See protein sequence)
Recommended Name: Early activation antigen CD69  
Size: 199 amino acids; 22559 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Membrane; Single-pass type II membrane protein
Developmental stage: Earliest inducible cell surface glycoprotein acquired during lymphoid activation
5 PDB 3D structures from and Proteopedia for CD69:
1E87 (3D)        1E8I (3D)        1FM5 (3D)        3CCK (3D)        3HUP (3D)    

Explore the universe of human proteins at neXtProt for CD69: NX_Q07108

Explore proteomics data for CD69 at MOPED 

Post-translational modifications:

  • UniProtKB: Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07108

  • CD69 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD69 Protein Expression
    REFSEQ proteins: NP_001772.1  
    ENSEMBL proteins: 
     ENSP00000228434   ENSP00000442597  

    Human Recombinant Protein Products for CD69: 
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    OriGene Protein Over-expression Lysate for CD69
    OriGene MassSpec for CD69 
    OriGene Custom Protein Services for CD69
    GenScript Custom Purified and Recombinant Proteins Services for CD69
    Novus Biologicals CD69 Proteins
    Novus Biologicals CD69 Lysates
    Sino Biological Recombinant Protein for CD69
    Sino Biological Cell Lysate for CD69 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS8340758
    GO:0009897external side of plasma membrane IEA--

    CD69 for ontologies           About GeneDecksing



    CD69 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD69
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    Abcam antibodies for CD69
    Browse Antibodies at Cloud-Clone Corp. 
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    LSBio Antibodies in human, mouse, rat for CD69 

    Assay Products for CD69: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    CLEC: C-type lectin domain containing

    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q07108

    ProtoNet protein and cluster: Q07108

    UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108
    Similarity: Contains 1 C-type lectin domain


    CD69 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD69_HUMAN, Q07108
    Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes,
    natural killer (NK) cells, and platelets
    Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of
    IL-2 with the p75 IL-2R on the surface of NK cells

         Genatlas biochemistry entry for CD69:
    cell differentiation antigen CD69,60kDa homodimer,membrane glycoprotein,in the NK (natural killer)
    complex,identified by monoclonal antibody C1.18,expressed in NK and many other hemopoietic cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS8340758
    GO:0030246carbohydrate binding IEA--
         
    CD69 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd69):
     cellular  hematopoietic system  immune system  no phenotypic analysis  skeleton 

    CD69 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD69: Cd69tm1Fsm Cd69tm1Naka

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD69 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD69

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD69 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD69 

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CD69 (see all 43):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCD69 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD69
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CD69

    Clone
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD69


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD69

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CD69 (Q071083 ENSP000002284344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035690cellular response to drug IEA--

    CD69 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD69 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD69

    10/44 Novoseek inferred chemical compound relationships for CD69 gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionomycin 67.8 18 16274628 (2), 12914753 (1), 8566003 (1), 9682002 (1) (see all 16)
    tyrosine 37.8 19 7682535 (2), 8477800 (2), 8103709 (2), 7489748 (1) (see all 13)
    thymidine 36.7 17 9188933 (2), 17575216 (1), 18844109 (1), 19255156 (1) (see all 15)
    phorbol 32 5 8977272 (1), 8301128 (1), 8977253 (1), 7664776 (1)
    con a 29.1 2 1373002 (1), 8979031 (1)
    cyclosporin a 27.3 19 11036825 (4), 12385031 (2), 18424069 (1), 8566003 (1) (see all 9)
    pd 98,059 23.2 4 15629076 (2), 11238629 (1), 9510155 (1)
    calcium 23 37 8566003 (3), 12899616 (3), 7682535 (2), 12841627 (2) (see all 19)
    isopentenyl diphosphate 19.3 2 9130649 (2)
    poly(i-c) 18.9 2 15634892 (1), 16728430 (1)

    Search CenterWatch for drugs/clinical trials and news about CD69

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD69 gene: 
    NM_001781.2  

    Unigene Cluster for CD69:

    CD69 molecule
    Hs.208854  [show with all ESTs]
    Unigene Representative Sequence: Z22576
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228434(uc001qwk.3) ENST00000536709(uc010sgu.2) ENST00000416624(uc010sgv.1)
    ENST00000543147
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD69
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CD69 (see all 43):
    hsa-miR-142-5p hsa-miR-106a hsa-miR-15a hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-424 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCD69 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD69
    Clone
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    OriGene clones in human, mouse for CD69 (see all 7)
    OriGene ORF clones in mouse, rat for CD69
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    GenScript: all cDNA clones in your preferred vector: CD69 (NM_001781)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD69
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD69
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD69
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD69

    Additional mRNA sequence: 

    AK291869.1 AK303174.1 AK303383.1 AY238518.1 BC007037.1 L07555.1 Z22576.1 

    6 DOTS entries:

    DT.114980  DT.40117198  DT.102825236  DT.99930976  DT.86852294  DT.99931337 

    24/197 AceView cDNA sequences (see all 197):

    AY238518 CK822697 CD678130 BM955743 BM955742 CD678131 CD521823 AA381443 
    Z22576 BG536370 BG771087 CD559338 AA482205 CA772173 BE969926 BM973572 
    CD642031 BF680636 CD521329 CD521291 CD639031 BG289842 BM543832 CD521944 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD69    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5
    SP1:              -           -                     
    SP2:              -           -     -               
    SP3:              -                                 
    SP4:                                                


    ECgene alternative splicing isoforms for CD69

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD69 expression in normal human tissues (normalized intensities)      CD69 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD69 Expression
    About this image


    CD69 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 13 entries
             T-Cytotoxic Cells Peripheral Blood
             Peripheral blood Pan-T Cells   
             BONE MARROW   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Cord Blood Pan-T Cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             PureStem ES-335, Meso-latp Progenitor
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Fetal Liver CD36+ Cells   

    See CD69 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD69

    SOURCE GeneReport for Unigene cluster: Hs.208854

    UniProtKB/Swiss-Prot: CD69_HUMAN, Q07108
    Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils,
    eosinophils, epidermal Langerhans cells and platelets

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD69: 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Th1/Th2 Response in human mouse rat
              Type I Interferon Response in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD69
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD69

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD69 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd691 , 5 CD69 antigen1, 5 70.56(n)1
    58.38(a)1
      6 (63.21 cM)5
    125151  NM_001033122.31  NP_001028294.11 
     1292673255 
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 15)
    --
    33(a)
    32(a)
    (see all 15)
    1 ↔ many
    1 ↔ many
    (see all 15)
    AADN03010709.1(196-1147)
    AADN03010643.1(7822-9309)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 15)
    Uncharacterized protein
    (see all 15)
    46(a)
    45(a)
    (see all 15)
    1 ↔ many
    1 ↔ many
    (see all 15)
    GL344089.1(7089-12704)
    GL343316.1(18858-20940)
    zebrafish
    (Danio rerio)
    Actinopterygii --
    --
    14(a)
    possible ortholog
    16(14031039-14044474)


    ENSEMBL Gene Tree for CD69 (if available)
    TreeFam Gene Tree for CD69 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD69 gene
    CLEC2D2  CLEC2L2  CLEC2A2  CLEC2B2  
    6 SIMAP similar genes for CD69 using alignment to 4 protein entries:     CD69_HUMAN (see all proteins):
    CLEC2A    CLEC2D    FCER2    CLEC2L    KLRD1    CLEC2B

    CD69 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/268 SNPs in CD69 are shown (see all 268)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs31768041,2
    C,F--9904617(-) GGAGCG/AAATCT 1 -- ds50014Minor allele frequency- A:0.12NA 164
    rs1168628271,2
    C,F--9904618(+) GATTCG/ACTCCC 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1858847921,2
    --9904641(+) CCTCCA/CACCAG 1 -- ds50010--------
    rs24013981,2
    C,F,A,H--9904679(+) ATGCGC/ACATGA 1 -- ds500112Minor allele frequency- A:0.31NS EA NA WA 816
    rs31768021,2
    C,F,O,A,H--9904807(-) TGCTAC/TATACA 1 -- ds500127Minor allele frequency- T:0.17NA NS EA WA CSA 2818
    rs1911371921,2
    --9904867(+) TATTAC/TAGAGC 1 -- ds50010--------
    rs1503749901,2
    --9904880(+) CTGCTA/CTATAC 1 -- ds50010--------
    rs8879011,2
    C,F,H--9904996(-) CTTAGA/GAAAAA 1 -- ds500113Minor allele frequency- G:0.09NS EA NA WA 792
    rs2001681641,2
    C--9905008(+) TATAGA/TAACTG 1 -- ds50010--------
    rs3744551721,2
    C--9905011(+) GTAAC-/CTTGTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CD69 (9905082 - 9913497 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD69:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv466e1CNV Complex17122850
    dgv468e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107273    OMIM disorders: --

    20/78 diseases for CD69 (see all 78):    About MalaCards
    intermediate uveitis    coccidioidomycosis    stromal keratitis    toxic shock syndrome
    lichen sclerosus    eosinophilic pneumonia    arthropathy    hypereosinophilic syndrome
    aphthous stomatitis    stomatitis    uveitis    thymoma
    tongue cancer    peritonitis    tetanus    pulmonary sarcoidosis
    human immunodeficiency virus infectious disease    graves' disease    mastocytosis    synovitis

    6 diseases from the University of Copenhagen DISEASES database for CD69:
    Hypersensitivity reaction type II disease     Cancer     Rheumatoid arthritis     Human immunodeficiency virus infectious disease
    Asthma     Connective tissue disease

    CD69 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/59 Novoseek inferred disease relationships for CD69 gene (see all 59)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 40.1 20 10361243 (1), 11270597 (1), 16751018 (1), 15010848 (1) (see all 17)
    rheumatoid arthritis 34.5 10 8702434 (2), 8323399 (2), 10466080 (1), 11036825 (1) (see all 8)
    autoimmune diseases 33.3 1 14604548 (1)
    leukemia b-cell 31.9 1 12684639 (1)
    asthma allergic 30.5 1 10445598 (1)
    lymphocytic leukemia chronic b-cell 30.4 1 12684639 (1)
    pneumonia eosinophilic 28.7 5 1500624 (2), 8031251 (1)
    inflammation 26.4 4 15693863 (1), 10726729 (1), 7664776 (1)
    immunodeficiency 26.1 3 9067659 (2), 10516611 (1)
    tumors 23 23 20116265 (2), 16332516 (1), 11270597 (1), 1612643 (1) (see all 21)

    Genetic Association Database (GAD): CD69
    Human Genome Epidemiology (HuGE) Navigator: CD69 (7 documents)

    Export disorders for CD69 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD69 gene, integrated from 9 sources (see all 561):
    (articles sorted by number of sources associating them with CD69)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. (PubMed id 8340758)1, 2, 9 Lopez-Cabrera M.... Sanchez-Madrid F. (1993)
    2. Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. (PubMed id 11101293)1, 2, 9 Natarajan K.... Mariuzza R.A. (2000)
    3. Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. (PubMed id 8100776)1, 2, 9 Ziegler S.F....Alderson M.R. (1993)
    4. Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. (PubMed id 1612643)1, 3, 9 Cambiaggi C....Accolla R.S. (1992)
    5. In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium. (PubMed id 20378605)1, 4 Qu H.Q....Polychronakos C. (2010)
    6. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (2009)
    7. Investigation of CD69 as a new candidate gene for rheumatoid arthritis. (PubMed id 18627570)1, 4 Rueda B....Martin J. (2008)
    8. Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice. (PubMed id 18959746)1, 2 Vanek O....Bezouska K. (2008)
    9. Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency. (PubMed id 18593762)1, 4 Skinningsrud B....Undlien D.E. (2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 969 HGNC: 1694 AceView: CD69 Ensembl:ENSG00000110848 euGenes: HUgn969
    ECgene: CD69 H-InvDB: CD69

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD69 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD69 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_235

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD69 gene:
    Search GeneIP for patents involving CD69

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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