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Aliases for CD68 Gene

Aliases for CD68 Gene

  • CD68 Molecule 2 3
  • CD68 Antigen 2 2 3 4
  • Macrophage Antigen CD68 2 3
  • GP110 3 4
  • Scavenger Receptor Class D, Member 1 3
  • Scavenger Receptor Class D 2
  • Macrosialin 3
  • Member 1 2
  • SCARD1 3
  • LAMP4 3

External Ids for CD68 Gene

Summaries for CD68 Gene

Entrez Gene Summary for CD68 Gene

  • This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD68 Gene

CD68 (CD68 Molecule) is a Protein Coding gene. Diseases associated with CD68 include rhinoscleroma and verruciform xanthoma of skin. Among its related pathways are Lysosome and LDL Oxidation in Atherogenesis. An important paralog of this gene is LAMP3.

UniProtKB/Swiss-Prot for CD68 Gene

  • Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD68 Gene

Genomics for CD68 Gene

Genomic Location for CD68 Gene

Start:
7,579,467 bp from pter
End:
7,582,113 bp from pter
Size:
2,647 bases
Orientation:
Plus strand

Genomic View for CD68 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD68 Gene

Regulatory Elements for CD68 Gene

Transcription factor binding sites by QIAGEN in the CD68 gene promoter:

Proteins for CD68 Gene

  • Protein details for CD68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34810-CD68_HUMAN
    Recommended name:
    Macrosialin
    Protein Accession:
    P34810
    Secondary Accessions:
    • B4DVT4
    • Q53HR6
    • Q53XI3
    • Q96BI7

    Protein attributes for CD68 Gene

    Size:
    354 amino acids
    Molecular mass:
    37408 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD68 Gene

Proteomics data for CD68 Gene at MOPED

Post-translational modifications for CD68 Gene

  • N- and O-glycosylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn88, Asn96, Asn118, Asn126, Asn164, Asn199, Asn246, Asn261, and Asn279

Other Protein References for CD68 Gene

No data available for DME Specific Peptides for CD68 Gene

Domains for CD68 Gene

Gene Families for CD68 Gene

HGNC:
  • CD :CD molecules

Protein Domains for CD68 Gene

Suggested Antigen Peptide Sequences for CD68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34810

UniProtKB/Swiss-Prot:

CD68_HUMAN
Family:
  • Belongs to the LAMP family.:
    • P34810
genes like me logo Genes that share domains with CD68: view

Function for CD68 Gene

Molecular function for CD68 Gene

GENATLAS Biochemistry: cell differentiation antigen CD68,110 kDa,recognized by monoclonal antibodies,highly expressed by monocytes and macrophages,member of the LAMP macrosialin family of hemapoietic mucin-like molecules
UniProtKB/Swiss-Prot Function: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells
genes like me logo Genes that share phenotypes with CD68: view

Animal Models for CD68 Gene

MGI Knock Outs for CD68:

miRNA for CD68 Gene

miRTarBase miRNAs that target CD68

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for CD68 Gene

Localization for CD68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD68 Gene

Isoform Short: Cell membrane; Single-pass type I membrane protein.
Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD68 Gene COMPARTMENTS Subcellular localization image for CD68 gene
Compartment Confidence
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
cytoskeleton 3
extracellular 3
golgi apparatus 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome --
GO:0005886 plasma membrane IEA --
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with CD68: view

Pathways for CD68 Gene

genes like me logo Genes that share pathways with CD68: view

Pathways by source for CD68 Gene

1 Qiagen pathway for CD68 Gene
1 KEGG pathway for CD68 Gene

Interacting Proteins for CD68 Gene

Gene Ontology (GO) - Biological Process for CD68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071310 cellular response to organic substance IEA --
genes like me logo Genes that share ontologies with CD68: view

Compounds for CD68 Gene

(4) Novoseek inferred chemical compound relationships for CD68 Gene

Compound -log(P) Hits PubMed IDs
alpha-naphthyl acetate 51.8 2
paraffin 38 3
lipid 0 3
latex 0 1
genes like me logo Genes that share compounds with CD68: view

Transcripts for CD68 Gene

mRNA/cDNA for CD68 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD68 Gene

CD68 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD68 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3:
SP4: - -
SP5: -

Relevant External Links for CD68 Gene

GeneLoc Exon Structure for
CD68
ECgene alternative splicing isoforms for
CD68

Expression for CD68 Gene

mRNA expression in normal human tissues for CD68 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD68 Gene

This gene is overexpressed in Whole Blood (10.9) and Spleen (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CD68 Gene

SOURCE GeneReport for Unigene cluster for CD68 Gene Hs.647419

mRNA Expression by UniProt/SwissProt for CD68 Gene

P34810-CD68_HUMAN
Tissue specificity: Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
genes like me logo Genes that share expressions with CD68: view

Orthologs for CD68 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD68 35
  • 99.25 (n)
  • 99.15 (a)
CD68 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD68 35
  • 82.88 (n)
  • 77.95 (a)
CD68 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD68 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd68 35
  • 78.27 (n)
  • 75.32 (a)
Cd68 16
Cd68 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD68 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd68 35
  • 78.02 (n)
  • 72.81 (a)
zebrafish
(Danio rerio)
Actinopterygii CD68 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Lamp1 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
Species with no ortholog for CD68:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD68 Gene

ENSEMBL:
Gene Tree for CD68 (if available)
TreeFam:
Gene Tree for CD68 (if available)

Paralogs for CD68 Gene

Paralogs for CD68 Gene

genes like me logo Genes that share paralogs with CD68: view

Variants for CD68 Gene

Sequence variations from dbSNP and Humsavar for CD68 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs17607 - 7,581,464(+) TTATT(A/G)CTTTC missense, reference
rs1065396 -- 7,581,586(+) CACGC(A/C)ACTGG utr-variant-3-prime
rs1065397 -- 7,581,587(+) ACGCA(A/G)CTGGC utr-variant-3-prime
rs9896688 -- 7,580,597(+) CCATG(A/T)CCTCA intron-variant
rs9901673 -- 7,580,783(+) CAGCA(A/C)GTAAG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for CD68 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907651 CNV Loss 21882294

Relevant External Links for CD68 Gene

HapMap Linkage Disequilibrium report
CD68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD68 Gene

Disorders for CD68 Gene

(19) Novoseek inferred disease relationships for CD68 Gene

Disease -log(P) Hits PubMed IDs
granular cell tumor 70.8 3
hemangioma 38 1
lymphoma large cell 37 2
malignant fibrous histiocytoma 33.8 1
osteoarthritis 32.2 2
genes like me logo Genes that share disorders with CD68: view

No data available for UniProtKB/Swiss-Prot for CD68 Gene

Publications for CD68 Gene

  1. The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13. (PMID: 9790779) Jones E. … Greaves D.R. (Genomics 1998) 2 3 4
  2. Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. (PMID: 15214825) Le B.H. … Kapadia S.B. (Arch. Pathol. Lab. Med. 2004) 3 23
  3. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. (PMID: 7680921) Holness C.L. … Simmons D.L. (Blood 1993) 3 4
  4. [The "classical" macrophage marker CD68 is strongly expressed in primary human fibroblasts]. (PMID: 16888915) Kunz-Schughart L.A. … Kreutz M. (Verh Dtsch Ges Pathol 2003) 3 23
  5. Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner. (PMID: 12676954) O'Reilly D. … Greaves D.R. (J. Biol. Chem. 2003) 3 23

Products for CD68 Gene

  • Addgene plasmids for CD68

Sources for CD68 Gene

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