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CD68 Gene

protein-coding   GIFtS: 61
GCID: GC17P007482

CD68 Molecule

(Previous name: CD68 antigen)
  See CD68-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD68 Molecule1 2     LAMP42
CD68 Antigen1 2 3     SCARD12
Macrophage Antigen CD681 2     macrosialin2
Member 11     Scavenger Receptor Class D, Member 12
Scavenger Receptor Class D1     Gp1103
GP1102     

External Ids:    HGNC: 16931   Entrez Gene: 9682   Ensembl: ENSG000001292267   OMIM: 1536345   UniProtKB: P348103   

Export aliases for CD68 gene to outside databases

Previous GC identifers: GC17P007896 GC17P008222 GC17P007426 GC17P007683 GC17P007423 GC17P007376


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD68 Gene:
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue
macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The
protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface.
It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue-
and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger
receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and
activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CD68 Gene:
CD68 (CD68 molecule) is a protein-coding gene. Diseases associated with CD68 include verruciform xanthoma of skin, and rhinoscleroma. An important paralog of this gene is LAMP1.

UniProtKB/Swiss-Prot: CD68_HUMAN, P34810
Function: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal
metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific
lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from
endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or
other cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD68 gene promoter:
         p53   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD68 promoter sequence
   Search Chromatin IP Primers for CD68

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD68


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

CD68 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD68 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007482:  view genomic region     (about GC identifiers)

Start:
7,482,785 bp from pter      End:
7,485,429 bp from pter
Size:
2,645 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD68_HUMAN, P34810 (See protein sequence)
Recommended Name: Macrosialin precursor  
Size: 354 amino acids; 37408 Da
Caution: CD68 is a commonly used marker for macrophages. However, a number of studies (PubMed:15194571,
PubMed:15647451 and PubMed:18405323) have shown that CD68 antibodies react with other hematopoietic and
non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen
Secondary accessions: B4DVT4 Q53HR6 Q53XI3 Q96BI7
Alternative splicing: 3 isoforms:  P34810-1   P34810-2   P34810-3   

Explore the universe of human proteins at neXtProt for CD68: NX_P34810

Explore proteomics data for CD68 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated1
  • Glycosylation2 at Asn88, Asn96, Asn118, Asn126, Asn164, Asn199, Asn246, Asn261, Asn279
  • Modification sites at PhosphoSitePlus

  • See CD68 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035148.1  NP_001242.2  

    ENSEMBL proteins: 
     ENSP00000250092   ENSP00000369867   ENSP00000462768   ENSP00000462198  

    CD68 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CD68
    Sino Biological Cell Lysate for CD68
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD68 

    CD68 Antibody Products:

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    Search eBioscience for ELISAs for CD68 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    2 InterPro protein domains:
     IPR018134 LAMP_CS
     IPR002000 Lysosome-assoc_membr_glycop

    Graphical View of Domain Structure for InterPro Entry P34810

    ProtoNet protein and cluster: P34810

    UniProtKB/Swiss-Prot: CD68_HUMAN, P34810
    Similarity: Belongs to the LAMP family


    Find genes that share domains with CD68           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD68_HUMAN, P34810
    Function: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal
    metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific
    lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from
    endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or
    other cells

         Genatlas biochemistry entry for CD68:
    cell differentiation antigen CD68,110 kDa,recognized by monoclonal antibodies,highly expressed by monocytes and
    macrophages,member of the LAMP macrosialin family of hemapoietic mucin-like molecules

    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd68):
     hematopoietic system  immune system  no phenotypic analysis  skeleton 

    Find genes that share phenotypes with CD68           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD68: Cd68tm1Xfen Cd68tm1.1Shnd Cd68tm1Shnd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD68
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD68

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD68
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD68

    miRNA
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    miRTarBase miRNAs that target CD68:
    hsa-mir-155-5p (MIRT020775)

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    3 qRT-PCR Assays for microRNAs that regulate CD68:
    hsa-miR-221* hsa-miR-3119 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidCD68 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CD68

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    Sino Biological Human cDNA Clone for CD68
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD68
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD68
    Addgene plasmids for CD68 

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    eBioscience FlowRNA Probe Sets ( VA1-11454 VA6-13284 VB6-12900) for CD68 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD68_HUMAN, P34810: Isoform Short: Cell membrane; Single-pass type I membrane protein
    CD68_HUMAN, P34810: Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane;
    Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    cytoskeleton3
    extracellular3
    golgi apparatus3
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0005886plasma membrane IEA--
    GO:0010008endosome membrane IEA--
    GO:0016020membrane TAS7680921
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CD68           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD68 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of CREB1
    Selected targets of CREB1
    2Lysosome
    Lysosome
    3LDL Oxidation in Atherogenesis
    LDL Oxidation in Atherogenesis


    Find genes that share SuperPaths with CD68           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CD68
        LDL Oxidation in Atherogenesis



    1 Kegg Pathway  (Kegg details for CD68):
        Lysosome

        Pathway & Disease-focused RT2 Profiler PCR Array including CD68: 
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD68

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for CD68 (P348102, 3 ENSP000002500924) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPI1P179473I2D: score=1 
    UCHL5ENSP000003564254STRING: ENSP00000356425
    USP14ENSP000002616014STRING: ENSP00000261601
    PSMD1ENSP000003094744STRING: ENSP00000309474
    PSMD2ENSP000003101294STRING: ENSP00000310129
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0071310cellular response to organic substance IEA--

    Find genes that share ontologies with CD68           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD68

    4 Novoseek inferred chemical compound relationships for CD68 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-naphthyl acetate 51.8 2 1648372 (1), 9951149 (1)
    paraffin 38 3 7684194 (1), 12475440 (1), 16888915 (1)
    lipid 0 3 9395269 (2), 7605375 (1)
    latex 0 1 15957187 (1)



    Find genes that share compounds with CD68           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD68 gene (2 alternative transcripts): 
    NM_001040059.1  NM_001251.2  

    Unigene Cluster for CD68:

    CD68 molecule
    Hs.647419  [show with all ESTs]
    Unigene Representative Sequence: NM_001251
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250092(uc002ghu.3 uc002ghv.3) ENST00000380498 ENST00000584502
    ENST00000584180
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CD68:
    hsa-miR-221* hsa-miR-3119 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidCD68 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CD68 (NM_001251)
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    Addgene plasmids for CD68 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD68
      QuantiTect SYBR Green Assays in human, mouse, rat CD68
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    Additional mRNA sequence: 

    AK222492.1 AK222514.1 AK290238.1 AK298055.1 AK301223.1 BC015557.2 BT009923.1 BX647524.1 
    S57235.1 

    Selected DOTS entries (see all 27):

    DT.95358847  DT.100885328  DT.100885329  DT.313808  DT.100885331  DT.100038254  DT.100737729  DT.97766257 
    DT.100853162  DT.120901565  DT.120901551  DT.120901611  DT.100692785  DT.100885337  DT.100885330  DT.100737730 
    DT.100885334  DT.120901660  DT.100707826  DT.100803402  DT.100885335  DT.120901440  DT.120901457  DT.120901584 

    8 AceView cDNA sequences:

    CR598533 CR606850 CR623004 BC015557 BT009923 BX647524 S57235 NM_001251 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CD68    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                    -     -                                                   
    SP5:                    -                                                         


    ECgene alternative splicing isoforms for CD68

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD68 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTCTTGT
    CD68 Expression
    About this image


    CD68 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             Macrophages Peripheral Blood
             Macrophage-like cells
     
     Placenta (Extraembryonic Tissues)
             Hofbauer Cells Chorionic Villus
     
     Chorion (Extraembryonic Tissues)
             Hofbauer Cells Chorionic Villus
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             Bone marrow-derived lineage-negative cells
    CD68 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD68 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647419

    UniProtKB/Swiss-Prot: CD68_HUMAN, P34810
    Tissue specificity: Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes,
    fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to
    selectins on vascular endothelium, facilitating their dissemination to secondary sites

        Pathway & Disease-focused RT2 Profiler PCR Array including CD68: 
              Hepatotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD68

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CD68 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd681 , 5 CD68 antigen1, 5 78.27(n)1
    75.32(a)1
      11 (42.86 cM)5
    125141  NM_009853.11  NP_033983.11 
     696642135 
    zebrafish
    (Danio rerio)
    Actinopterygii CD686
    CD68 molecule
    25(a)
    1 ↔ 1
    7(20639680-20649221) ENSDARG00000055504
    fruit fly
    (Drosophila melanogaster)
    Insecta Lamp16
    Lamp1
    18(a)
    1 → many
    2L(21573389-21577103)


    ENSEMBL Gene Tree for CD68 (if available)
    TreeFam Gene Tree for CD68 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD68 gene
    LAMP12  LAMP32  LAMP22  

    Find genes that share paralogs with CD68           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD68 (see all 109)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1917665101,2
    --7482905(+) ACTTTC/GATTTC 2 -- ut510--------
    rs1114876701,2
    C,F--7482986(+) TGAGGC/TGGTTC 2 -- ut511Minor allele frequency- T:0.50CSA 2
    rs2006778541,2
    --7483052(+) AAGGAA/GGAAGG 2 -- int10--------
    rs344748401,2
    C,F--7483132(-) GTCCCC/TTGGGC 3 Q syn1 int13Minor allele frequency- T:0.01NA WA 4742
    rs1450826721,2
    C--7483157(+) CTCACA/GAAAAA 3 K E mis1 int11Minor allele frequency- G:0.00NA 4548
    rs1471523471,2
    C,F--7483200(+) ACCCAC/TGGTTA 3 T M mis1 int12Minor allele frequency- T:0.01NA EU 5865
    rs743738471,2
    C--7483249(+) AGCCAA/CAAAAC 4 Q H mis10--------
    rs2000442981,2
    --7483305(+) CACGAC/TTGCCA 4 T I mis10--------
    rs2022404041,2
    --7483319(+) ACAACA/CCCACC 4 T P mis10--------
    rs1502605721,2
    C,F--7483336(+) AGCCAT/CGGAAA 4 /H syn12Minor allele frequency- C:0.00NA EU 5871

    HapMap Linkage Disequilibrium report for CD68 (7482785 - 7485429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD68:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    nsv457659CNV Loss19166990
    nsv907651CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153634    OMIM disorders: --

    16 diseases for CD68:    
    About MalaCards
    verruciform xanthoma of skin    rhinoscleroma    chondroid lipoma    liver sarcoma
    giant cell myocarditis    congenital granular cell tumor    multicentric reticulohistiocytosis    cutaneous fibrous histiocytoma
    follicular dendritic cell tumor    fibrous histiocytoma    pigmented villonodular synovitis    histiocytic sarcoma
    villonodular synovitis    pleomorphic xanthoastrocytoma    malignant histiocytosis    dendritic cell sarcoma

    16 diseases from the University of Copenhagen DISEASES database for CD68:
    Histiocytosis     Cancer     Granular cell tumor     Cutaneous fibrous histiocytoma
    Verruciform xanthoma of skin     Rheumatoid arthritis     Atherosclerosis     Multicentric reticulohistiocytosis
    Skin disease     Synovitis     Kidney disease     Encephalitis
    Osteoarthritis     Lung disease     Rhinoscleroma     Hypersensitivity reaction type II disease

    Find genes that share disorders with CD68           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD68 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    granular cell tumor 70.8 3 8878020 (1), 18581283 (1), 15214825 (1)
    hemangioma 38 1 11737304 (1)
    lymphoma large cell 37 2 1647137 (1), 8698322 (1)
    malignant fibrous histiocytoma 33.8 1 1676879 (1)
    osteoarthritis 32.2 2 16888915 (1), 8912515 (1)
    hodgkin disease 29.9 1 1320954 (1)
    lymphoma 29.2 1 19382036 (1)
    atherosclerotic plaque 27.4 1 9395269 (1)
    tumors 26.8 17 8094017 (2), 16888915 (2), 7628841 (1), 18302511 (1) (see all 13)
    synovitis 25.4 1 7628850 (1)


    Export disorders for CD68 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD68 gene, integrated from 10 sources (see all 181):
    (articles sorted by number of sources associating them with CD68)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13. (PubMed id 9790779)1, 2, 3 Jones E.... Greaves D.R. (Genomics 1998)
    2. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (Mol. Cell. Proteomics 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. (PubMed id 7680921)1, 2 Holness C.L. and Simmons D.L. (Blood 1993)
    5. [The &quot;classical&quot; macrophage marker CD68 is strongly expressed in primary human fibroblasts]. (PubMed id 16888915)1, 9 Kunz-Schughart L.A....Kreutz M. (Verh Dtsch Ges Pathol 2003)
    6. Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner. (PubMed id 12676954)1, 9 O'Reilly D....Greaves D.R. (J. Biol. Chem. 2003)
    7. Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. (PubMed id 15214825)1, 9 Le B.H....Kapadia S.B. (amp 2004)
    8. Macrophage/histiocytic antigen CD68 expression in neoplastic and reactive lymph nodes. (PubMed id 15638380)1, 9 Mazur G....Kuliczkowski K. (Rocz. Akad. Med. Bialymst. 2004)
    9. Prespecified candidate biomarkers identify follicular lymphoma patients who achieved longer progression-free survival with bortezomib-rituximab versus rituximab. (PubMed id 23549871)1 Coiffier B....Ricci D. (Clin. Cancer Res. 2013)
    10. Role of proinflammatory CD68(+) mannose receptor(-) macrophages in peroxiredoxin-1 expression and in abdominal aortic aneurysms in humans. (PubMed id 23241402)1 Boytard L....Pinet F. (Arterioscler. Thromb. Vasc. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 968 HGNC: 1693 AceView: CD68 Ensembl:ENSG00000129226 euGenes: HUgn968
    ECgene: CD68 Kegg: 968 H-InvDB: CD68

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CD68 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD68 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CD68 gene:
    Search GeneIP for patents involving CD68

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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