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Aliases for CD68 Gene

Aliases for CD68 Gene

  • CD68 Molecule 2 3 5
  • CD68 Antigen 2 2 3 4
  • Scavenger Receptor Class D, Member 1 2 3
  • Macrophage Antigen CD68 2 3
  • GP110 3 4
  • Macrosialin 3
  • SCARD1 3
  • LAMP4 3

External Ids for CD68 Gene

Previous GeneCards Identifiers for CD68 Gene

  • GC17P007896
  • GC17P008222
  • GC17P007426
  • GC17P007683
  • GC17P007423
  • GC17P007482
  • GC17P007376

Summaries for CD68 Gene

Entrez Gene Summary for CD68 Gene

  • This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD68 Gene

CD68 (CD68 Molecule) is a Protein Coding gene. Diseases associated with CD68 include Granular Cell Tumor and Bacterial Esophagitis. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. An important paralog of this gene is LAMP3.

UniProtKB/Swiss-Prot for CD68 Gene

  • Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Additional gene information for CD68 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD68 Gene

Genomics for CD68 Gene

Regulatory Elements for CD68 Gene

Enhancers for CD68 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H007474 1.8 FANTOM5 ENCODE dbSUPER 26.7 -98.9 -98878 12 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 SSRP1 DVL2 PFAS SNORD10 POLR2A SNORA48 CTC1 KCTD11 NEURL4 CHRNB1 CNTROB
GH17H007833 1.9 FANTOM5 ENCODE dbSUPER 14.1 +260.3 260263 12 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC DVL2 PFAS CTC1 WRAP53 POLR2A CNTROB SNORD10 ENSG00000265749 NLGN2 KDM6B
GH17H007347 1.4 ENCODE dbSUPER 6.4 -227.6 -227649 9 HDGF ARID4B SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF207 ZNF143 FOS DVL2 ELP5 GPS2 WRAP53 LOC100996842 PFAS PER1 CNTROB CD68 TNFSF13
GH17H007130 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.5 -447.3 -447256 3 HDGF PKNOX1 ARID4B ZNF143 ZNF207 ATF7 RUNX3 JUNB REST ZNF592 CLEC10A SLC16A11 ASGR1 BCL6B EIF5A RPL7AP64 TRAPPC1 CD68 GABARAP SAT2
GH17H007356 1 ENCODE 6.3 -223.1 -223051 0 HDGF SIN3A ZNF2 ZBTB7B ETS1 SLC30A9 ZNF207 ZNF143 KLF7 DEK CD68 TMEM95 GC17P007361
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD68 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CD68 gene promoter:

Genomic Location for CD68 Gene

Chromosome:
17
Start:
7,579,467 bp from pter
End:
7,582,113 bp from pter
Size:
2,647 bases
Orientation:
Plus strand

Genomic View for CD68 Gene

Genes around CD68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD68 Gene

Proteins for CD68 Gene

  • Protein details for CD68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34810-CD68_HUMAN
    Recommended name:
    Macrosialin
    Protein Accession:
    P34810
    Secondary Accessions:
    • B4DVT4
    • Q53HR6
    • Q53XI3
    • Q96BI7

    Protein attributes for CD68 Gene

    Size:
    354 amino acids
    Molecular mass:
    37408 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD68 Gene

Post-translational modifications for CD68 Gene

  • N- and O-glycosylated.
  • Glycosylation at posLast=8888, Asn96, Asn118, Asn126, posLast=164164, posLast=199199, posLast=246246, posLast=261261, and Asn279
  • Modification sites at PhosphoSitePlus

Other Protein References for CD68 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD68 (CD68)
  • Abcam antibodies for CD68

Protein Products

  • Abcam proteins for CD68

No data available for DME Specific Peptides for CD68 Gene

Domains & Families for CD68 Gene

Gene Families for CD68 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD68 Gene

Suggested Antigen Peptide Sequences for CD68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34810

UniProtKB/Swiss-Prot:

CD68_HUMAN :
  • Belongs to the LAMP family.
Family:
  • Belongs to the LAMP family.
genes like me logo Genes that share domains with CD68: view

Function for CD68 Gene

Molecular function for CD68 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD68,110 kDa,recognized by monoclonal antibodies,highly expressed by monocytes and macrophages,member of the LAMP macrosialin family of hemapoietic mucin-like molecules
UniProtKB/Swiss-Prot Function:
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Phenotypes From GWAS Catalog for CD68 Gene

genes like me logo Genes that share phenotypes with CD68: view

Animal Models for CD68 Gene

MGI Knock Outs for CD68:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD68

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD68
  • Applied Biological Materials Clones for CD68
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD68 Gene

Localization for CD68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD68 Gene

Isoform Short: Cell membrane; Single-pass type I membrane protein.
Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD68 gene
Compartment Confidence
plasma membrane 5
lysosome 5
endosome 5
extracellular 3
cytoskeleton 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane TAS,IEA 7680921
genes like me logo Genes that share ontologies with CD68: view

Pathways & Interactions for CD68 Gene

genes like me logo Genes that share pathways with CD68: view

Pathways by source for CD68 Gene

3 Reactome pathways for CD68 Gene
1 KEGG pathway for CD68 Gene

Gene Ontology (GO) - Biological Process for CD68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
GO:0071310 cellular response to organic substance IEA --
genes like me logo Genes that share ontologies with CD68: view

No data available for SIGNOR curated interactions for CD68 Gene

Drugs & Compounds for CD68 Gene

(4) Additional Compounds for CD68 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD68: view

Transcripts for CD68 Gene

mRNA/cDNA for CD68 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD68 Gene

CD68 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD68
  • Applied Biological Materials Clones for CD68
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CD68 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3:
SP4: - -
SP5: -

Relevant External Links for CD68 Gene

GeneLoc Exon Structure for
CD68
ECgene alternative splicing isoforms for
CD68

Expression for CD68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD68 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD68 Gene

This gene is overexpressed in Whole Blood (x10.9) and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for CD68 Gene

This gene is overexpressed in Spleen (15.0) and Monocytes (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD68 Gene



Protein tissue co-expression partners for CD68 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD68 Gene:

CD68

SOURCE GeneReport for Unigene cluster for CD68 Gene:

Hs.647419

mRNA Expression by UniProt/SwissProt for CD68 Gene:

P34810-CD68_HUMAN
Tissue specificity: Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

Evidence on tissue expression from TISSUES for CD68 Gene

  • Skin(4.8)
  • Spleen(4.8)
  • Blood(4.7)
  • Liver(4.7)
  • Nervous system(3.9)
  • Lung(3.7)
  • Lymph node(3.7)
  • Heart(3.5)
  • Bone marrow(3.4)
  • Muscle(3.4)
  • Intestine(3.3)
  • Kidney(3.3)
  • Stomach(2.6)
  • Gall bladder(2.5)
  • Bone(2.3)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with CD68: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD68 Gene

Orthologs for CD68 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD68 33 34
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia CD68 33 34
  • 82.88 (n)
mouse
(Mus musculus)
Mammalia Cd68 33 16 34
  • 78.27 (n)
rat
(Rattus norvegicus)
Mammalia Cd68 33
  • 78.02 (n)
dog
(Canis familiaris)
Mammalia CD68 34
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD68 34
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CD68 34
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Lamp1 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
ManyToMany
-- 34
  • 17 (a)
ManyToMany
Species where no ortholog for CD68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD68 Gene

ENSEMBL:
Gene Tree for CD68 (if available)
TreeFam:
Gene Tree for CD68 (if available)

Paralogs for CD68 Gene

Paralogs for CD68 Gene

genes like me logo Genes that share paralogs with CD68: view

Variants for CD68 Gene

Sequence variations from dbSNP and Humsavar for CD68 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000205759 -- 7,578,715(+) AAAAA(A/C)ACACT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001624068 -- 7,581,246(+) CCTTT(C/T)ATCAC intron-variant
rs1002739188 -- 7,579,174(+) TGACA(A/G)TGCTG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003335256 -- 7,580,323(+) TGGAG(A/G)AGAGG reference, missense
rs1003391749 -- 7,581,638(+) AAAAG(A/C)AAGCC intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CD68 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781

Variation tolerance for CD68 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.44; 77.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD68 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD68 Gene

Disorders for CD68 Gene

MalaCards: The human disease database

(98) MalaCards diseases for CD68 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CD68 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD68

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD68
genes like me logo Genes that share disorders with CD68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD68 Gene

Publications for CD68 Gene

  1. The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13. (PMID: 9790779) Jones E … Greaves DR (Genomics 1998) 2 3 4 60
  2. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PMID: 16263699) Lewandrowski U … Sickmann A (Molecular & cellular proteomics : MCP 2006) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Macrophage/histiocytic antigen CD68 expression in neoplastic and reactive lymph nodes. (PMID: 15638380) Mazur G … Kuliczkowski K (Roczniki Akademii Medycznej w Bialymstoku (1995) 2004) 3 22 60
  5. Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. (PMID: 15214825) Le BH … Kapadia SB (Archives of pathology & laboratory medicine 2004) 3 22 60

Products for CD68 Gene

  • Addgene plasmids for CD68

Sources for CD68 Gene

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