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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD63 Gene

protein-coding GIFtS: 64
GCID: GC12M056119

CD63 molecule

(Previous name: CD63 antigen (melanoma 1 antigen) )
(Previous symbol: MLA1)

Explore 54 diseases affiliated with
CD63 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD63 Molecule¹ ²		CD63 Antigen² ³
MLA1¹ ² ³ ⁵		Granulophysin³
TSPAN30¹ ² ³		Lysosome-Associated Membrane Glycoprotein 3²
ME491¹ ²		Melanoma-Associated Antigen MLA1²
CD63 Antigen (Melanoma 1 Antigen)¹ ²		Tetraspanin-30³
Lysosomal-Associated Membrane Protein 3² ³		Tspan-30³
Melanoma-Associated Antigen ME491² ³		Granulophysin³
Ocular Melanoma-Associated Antigen² ³		Tetraspanin-30³
LAMP-3² ³		Tspan-30³
OMA81H² ³

External Ids:	HGNC: 1692¹	Entrez Gene: 967²	Ensembl: ENSG00000135404⁷	OMIM: 155740⁵	UniProtKB: P08962³

Export aliases for CD63 gene to outside databases

Previous GC identifers: GC12M056043 GC12M056192 GC12M055834 GC12M054405 GC12M053159

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD63:

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.

Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,

growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It

may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak

syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple

transcript variants encoding different protein isoforms. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: CD63_HUMAN, P08962

Function: This antigen is associated with early stages of melanoma tumor progression. May play a role in growth

regulation

Gene Wiki entry for CD63

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD63 gene promoter:
GR C/EBPbeta Sp1 GR-beta Nkx2-5 c-Ets-1 HEN1 GR-alpha LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD63 promoter sequence

Search SABiosciences Chromatin IP Primers for CD63

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD63

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12-q13 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q12-q13

CD63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD63 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M056119: view genomic region (about GC identifiers)

Start:	56,119,107 bp from pter	End:	56,123,491 bp from pter
Size:	4,385 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD63_HUMAN, P08962 (See protein sequence)

Recommended Name: CD63 antigen

Size: 238 amino acids; 25637 Da

Subcellular location: Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late

endosome membrane; Multi-pass membrane protein. Note=Also found in Weibel-Palade bodies of endothelial cells. Located

in platelet dense granules

Miscellaneous: Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome

(HPS). Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder

characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage

defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense

granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature

death in individuals with HPS

Secondary accessions: Q5TZP3 Q8N6Z9 Q9UCG6

Alternative splicing: 2 isoforms: P08962-1 P08962-2

Explore the universe of human proteins at neXtProt for CD63: NX_P08962

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08962

CD63 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (8 alternative transcripts):

NP_001244318.1 NP_001244319.1 NP_001244320.1 NP_001244321.1 NP_001244329.1 NP_001244330.1 NP_001254627.1 NP_001771.1

ENSEMBL proteins:

ENSP00000447938 ENSP00000449684 ENSP00000393502 ENSP00000449654 ENSP00000447356

ENSP00000449337 ENSP00000447730 ENSP00000257857 ENSP00000449435 ENSP00000446807

ENSP00000448091 ENSP00000449281 ENSP00000446752 ENSP00000450191

Reactome Protein details: P08962
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD63

Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005764	lysosome	--	--
GO:0005765	lysosomal membrane	IEA	--
GO:0005770	late endosome	--	--
GO:0005886	plasma membrane	TAS	--

CD63 for ontologies About GeneDecksing

CD63 Antibody Products:

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	Novus Biologicals CD63 Antibodies
	Abcam antibodies for CD63
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	ThermoFisher Antibody for CD63

Assay Products for CD63:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD63
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD63

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD63 for domains About GeneDecksing

4 InterPro domains/families:

IPR018499 Tetraspanin/Peripherin

IPR000301 Tetraspanin

IPR008952 Tetraspanin_EC2

IPR018503 Tetraspanin_CS

Graphical View of Domain Structure for InterPro Entry P08962

ProtoNet protein and cluster: P08962

1 Blocks protein family: IPB000301 Transmembrane four family signature

UniProtKB/Swiss-Prot: CD63_HUMAN, P08962

Similarity: Belongs to the tetraspanin (TM4SF) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD63_HUMAN, P08962

Function: This antigen is associated with early stages of melanoma tumor progression. May play a role in growth

regulation

Genatlas biochemistry entry for CD63:

cell differentiation antigen CD63 (melanoma 1 antigen)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD63 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD63
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		hsa-miR-548d-3p hsa-miR-490-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD63

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD63
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CD63

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032403	protein complex binding	--	--

CD63 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CD63:

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Cd63^tm1Psa for CD63
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cd63):

behavior/neurological

digestive/alimentary

homeostasis/metabolism

renal/urinary system

CD63 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Selected targets of ESR1

Selected targets of ESR1

1.00

Lysosome

Lysosome

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CD63

Selected targets of ESR1

4 Reactome Pathways for CD63

	Hemostasis
	Platelet degranulation
	Platelet activation, signaling and aggregation
	Response to elevated platelet cytosolic Ca2+

1 Kegg Pathway (Kegg details for CD63):

Lysosome

CD63 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD63

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/49 Interacting proteins for CD63 (P08962^{2, 3} ENSP00000257857⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTGFRN	Q9P2B2²^,³, ENSP00000376899⁴	MINT-8407185 I2D: score=2 STRING: ENSP00000376899
TIMP1	P01033²^,³, ENSP00000218388⁴	MINT-2981831 MINT-2981920 MINT-2981902 MINT-2981857 MINT-2981881 I2D: score=2 STRING: ENSP00000218388
ITGB1	P05556²^,³, ENSP00000364094⁴	MINT-2981958 MINT-2981939 MINT-8407185 I2D: score=2 STRING: ENSP00000364094
CD81	P60033²^,³, ENSP00000263645⁴	MINT-8407185 I2D: score=1 STRING: ENSP00000263645
ITGA6	P23229²^,³, ENSP00000386896⁴	MINT-8407185 I2D: score=2 STRING: ENSP00000386896

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0010633	negative regulation of epithelial cell migration	--	--
GO:0030168	platelet activation	TAS	--
GO:0030855	epithelial cell differentiation	--	--

CD63 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD63 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD63
10/23 Novoseek chemical compound relationships for CD63 gene (see all 23) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mdmp	75.2	1	15668187 (1)
pdmp	69.7	3	15203718 (1), 14679788 (1), 15668187 (1)
adp	60.3	18	7519037 (3), 7684475 (1), 8062509 (1), 18217151 (1) (see all 11)
fibrinogen	52.1	22	8062509 (2), 8115992 (2), 8560414 (2), 7519037 (2) (see all 14)
mannose 6-phosphate	47.8	3	19888988 (1), 11764278 (1), 17959629 (1)
thromboxane a2	40.2	1	8928869 (1)
rantes	38.7	10	12010805 (4), 15668187 (2), 15829999 (1), 12361207 (1)
clopidogrel	19.2	2	18217151 (1), 12637702 (1)
epinephrine	18.1	2	12637702 (1), 17549300 (1)
aspirin	17.1	3	12695747 (2), 12637702 (1)

Search CenterWatch for drugs/clinical trials and news about CD63

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD63 gene (9 alternative transcripts):

NM_001257389.1 NM_001257390.1 NM_001257391.1 NM_001257392.1 NM_001257400.1 NM_001257401.1 NM_001267698.1 NM_001780.5

NM_001040034.1

Unigene Cluster for CD63:

CD63 molecule

Hs.445570 [show with all ESTs]

Unigene Representative Sequence: BM809097

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000548898 ENST00000548117 ENST00000552067 ENST00000420846 ENST00000548160

ENST00000546939 ENST00000552692(uc009znz.3) ENST00000549117 ENST00000257857(uc001shn.3 uc001sho.3)

ENST00000550050 ENST00000552754 ENST00000550776 ENST00000555199 ENST00000552164

ENST00000551173 ENST00000546457

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD63
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD63:
		hsa-miR-548d-3p hsa-miR-490-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD63 (see all 7) OriGene shRNA RFP: CD63 OriGene siRNA: CD63
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD63

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD63 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD63 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD63
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD63

Additional cDNA sequence:

AF508304.1 AK311893.1 BC002349.2 BC013017.2 BT007073.1 BT020137.1 BT020138.1 CR542096.1

M58485.1 M59907.1 S93788.1 X07982.1

24/45 DOTS entries (see all 45):

DT.100045710 DT.92464516 DT.92464504 DT.97806488 DT.97838247 DT.100703308 DT.92464535 DT.100892203

DT.95133114 DT.100892222 DT.100892200 DT.100892213 DT.92464537 DT.100045720 DT.100892216 DT.95133186

DT.121147407 DT.95069045 DT.97864758 DT.100034582 DT.101965775 DT.114899 DT.91941712 DT.97864484

24/1311 AceView cDNA sequences (see all 1311):

BF338855 AA552365 AA182041 CR600108 CR601904 BU155574 BE896060 BF526426

BE872920 BU168899 AA365698 CR598829 BQ887578 AA121623 BQ680237 CN482693

BU154060 AF508304 BQ678609 AA605231 BM849751 M59907 CK905018 BQ678600

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CD63 (see all 11) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	·	13c	·	13d
SP1:											-		-		-				-		-						-										-
SP2:							-		-		-		-		-				-		-						-										-
SP3:																			-		-		-				-										-
SP4:			-				-		-		-		-		-				-		-						-
SP5:													-		-				-		-						-

ECgene alternative splicing isoforms for CD63

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD63 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCGAAGAACC

About this image

CD63 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Perichondrium

Endochondral Preosteoblasts

Bone

Cervical Vertebrae

Endochondral Preosteoblasts

Bone

Lumbar Vertebrae

Endochondral Preosteoblasts

Bone

Sacral Vertebrae

Endochondral Preosteoblasts

Bone

Stylopod Perichondrium

Endochondral Preosteoblasts

Bone

Thoracic Rib

Endochondral Preosteoblasts

Bone

Thoracic Vertebrae

Endochondral Preosteoblasts

Bone

Zeugopod Perichondrium

Endochondral Preosteoblasts

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Expanded PAX7 cells (Generation of skelet...)

See CD63 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD63

SOURCE GeneReport for Unigene cluster: Hs.445570

UniProtKB/Swiss-Prot: CD63_HUMAN, P08962

Tissue specificity: Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages

SABiosciences Expression via Pathway-Focused PCR Array including CD63:

Cell Surface Markers in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CD63

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CD63 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TSPAN10⁶	Uncharacterized protein	16(a)	1 ↔ 1	18(9171654-9173233)
lizard (Anolis carolinensis)	Reptilia	CD63⁶ --	--	50(a) 23(a)	1 ↔ 1 possible ortholog	GL343198.1(1868704-1887884) 1(78949526-78956918)
African clawed frog (Xenopus laevis)	Amphibia	BC054957.1²	--	78.17(n)		BC054957.1
zebrafish (Danio rerio)	Actinopterygii	BC064300.1²	--	68.96(n)		321461 BC064300.1
fruit fly (Drosophila melanogaster)	Insecta	Tsp29Fa¹	Tetraspanin 29Fa	50.37(n) 33.78(a)		34211 NM_001169444.1 NP_001162915.1
worm (Caenorhabditis elegans)	Secernentea	tsp-7¹	Protein TSP-7	45.55(n) 35.29(a)		192062 NM_060235.1 NP_492636.1

ENSEMBL Gene Tree for CD63 (if available)
TreeFam Gene Tree for CD63 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD63 gene

CD151² TSPAN1² CD37² TSPAN6² TSPAN9² TSPAN3² CD53² CD82²

TSPAN18² TSPAN7² TSPAN4² TSPAN11² ENSG00000250349² TSPAN8²

18/21 SIMAP similar genes for CD63 using alignment to 8 protein entries: CD63_HUMAN (see all proteins) (see all similar genes):

CD151 BTCC-1 TSPAN7 TM4SF2 TSPAN11 CD9

TSPAN4 TSPAN6 TSPAN9 TSPAN3 TSPAN33 TSPAN2

TSPAN18 TM4SF9 TSPAN5 TSPAN8 TSPAN14 TSPAN17

CD63 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3138134^1,2	C,F,H,	--	53157648(-)	`TGACAC/TCTGTG`	2	--	ds500¹		16		NA NS EA CSA WA	1679
rs112938433^1,2	C	--	53159747(+)	`CAACTA/C/GACCGT`	8	--	int¹		1		CSA	1
rs111462959^1,2	C	--	53159749(+)	`ACTCAA/C/GCGTGA`	8	--	spd¹		1		CSA	1
rs11542879^1,2	C	--	53159777(-)	`GCCTGC/TAAGGA`	14	C	syn¹ ut5¹		2		NA	4
rs772257^1,2	C,F,H,	--	53160009(-)	`GTGTAC/TCCCCT`	8	--	int¹		6		NS NA WA	722
rs772256^1,2		--	53161960(-)	`TCTCAC/TCCACC`	8	--	ut5¹ us2k¹ ese³		3		MN NA	188
rs2231462^1,2	C,F,H,	--	53162181(-)	`ACACCC/TAGGAT`	8	--	ut5¹ us2k¹ ese³		11		NS NA CSA WA	1530
rs113644152^1,2		--	53162304(+)	`CGAAGC/TCACGC`	8	--	us2k¹		2		CSA WA	120
rs772255^1,2	C,F,A,H,	--	53162864(+)	`AGAGCA/TGAAGA`	6	--	us2k¹ trp³		23		EA NA NS CSA WA	1913
rs2694015^1,2		--	53163464(-)	`AAGAGA/GAAAAA`	3	--	us2k¹ trp³		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD63 (56119107 - 56123491 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD63: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD63

DNA2.0 Custom Variant and Variant Library Synthesis for CD63

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD63 for disorders           About GeneDecksing

OMIM gene information: 155740    OMIM disorders: --

20/54 diseases for CD63 (see all 54):    About MalaCards

hermansky-pudlak syndrome platelet storage pool deficiency ocular melanoma melanoma

von willebrand's disease pre-eclampsia type 2 diabetes mellitus arteriosclerosis obliterans

myocardial infarction atrial fibrillation acute myocardial infarction merkel cell carcinoma

diphtheria diabetes mellitus arteriosclerosis head injury

megakaryoblastic leukemia intrahepatic cholangiocarcinoma antiphospholipid syndrome mastocytosis

4 diseases from the University of Copenhagen DISEASES database for CD63:

Hypersensitivity reaction type I disease Hermansky-Pudlak syndrome Urticaria Melanoma

10/23 Novoseek disease relationships for CD63 gene (see all 23) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hermansky-pudlak syndrome	78.4	5	7682577 (2), 1515640 (1)
platelet storage pool deficiency	68.3	1	1515640 (1)
melanoma	49.1	48	8630057 (6), 9120293 (5), 12740908 (2), 12150730 (2) (see all 20)
metastatic melanoma	18.7	1	8219756 (1)
von willebrand disease	17.5	1	10203098 (1)
metastasis	15.5	6	15375577 (2), 12480921 (1), 12740908 (1), 7665237 (1)
preeclampsia	11.5	5	8062509 (2), 15118653 (2)
niddm	7.73	1	16093733 (1)
tumors	6.05	10	9120293 (2), 10515601 (1), 16475205 (1), 12150730 (1) (see all 7)
diphtheria	5.72	1	11235900 (1)

Human Genome Epidemiology (HuGE) Navigator: CD63 (3 documents)

Export disorders for CD63 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CD63 gene, integrated from 9 sources (see all 337):
(articles sorted by number of sources associating them with CD63)

Utopia: connect your pdf to the dynamic
world of online information

The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin. (PubMed id 7682577)^{1, 2, 9} Nishibori M.... Gerrard J.M. (1993)
An ocular melanoma-associated antigen. Molecular characterization. (PubMed id 1339263)^{1, 2, 9} Wang M.X.... Donoso L.A. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{1, 2} Zhang H.... Aebersold R. (2003)
Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences. (PubMed id 1599482)^{1, 2} Hotta H.... Homma M. (1992)
CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells. (PubMed id 1993697)^{1, 2} Metzelaar M.J.... Clevers H.C. (1991)
Characterization of three abundant mRNAs from human ovarian granulosa cells. (PubMed id 2171551)^{1, 2} Rapp G....Scheit K.H. (1990)
Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression. (PubMed id 3365686)^{1, 2} Hotta H.... Koprowski H. (1988)
Isolation and amino terminal sequencing of a novel melanoma- associated antigen. (PubMed id 4062294)^{1, 2} Ross A.H.... Koprowski H. (1985)
CD82, and CD63 in thyroid cancer. (PubMed id 15375577)^{1, 9} Chen Z....Hoang-Vu C. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 967	HGNC: 1692	AceView: CD63	Ensembl:ENSG00000135404	euGenes: HUgn967
ECgene: CD63	Kegg: 967	H-InvDB: CD63

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CD63	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD63	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CD63 gene
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Patent Information for CD63 gene:
Search GeneIP for patents involving CD63

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CD63 (Gene Symbol)
CD63 Molecule
MLA1
TSPAN30
ME491
CD63 Antigen (Melanoma 1 Antigen)
Lysosomal-Associated Membrane Protein 3
Melanoma-Associated Antigen ME491
Ocular Melanoma-Associated Antigen
LAMP-3
OMA81H
CD63 Antigen
Granulophysin
Lysosome-Associated Membrane Glycoprotein 3
Melanoma-Associated Antigen MLA1
Tetraspanin-30
Tspan-30
Granulophysin
Tetraspanin-30
Tspan-30

Melanoma
von Willebrand Disease
Platelet Storage Pool Deficiency
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immunodeficiency
STROKE
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HERMANSKY-PUDLAK SYNDROME
prostate cancer
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metastatic melanoma
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