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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD6 Gene

protein-coding   GIFtS: 62
GCID: GC11P060743

CD6 Molecule

(Previous name: CD6 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD6 Molecule1 2
CD6 Antigen1 2 3
TP1202 3 5
T122 3
T-Cell Differentiation Antigen CD62

External Ids:    HGNC: 16911   Entrez Gene: 9232   Ensembl: ENSG000000137257   OMIM: 1867205   UniProtKB: P302033   

Export aliases for CD6 gene to outside databases

Previous GC identifers: GC11P063132 GC11P062252 GC11P060990 GC11P060514 GC11P060495 GC11P057086


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD6 Gene:
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The
encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an
activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.
This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for CD6 Gene: 
CD6 (CD6 molecule) is a protein-coding gene. Diseases associated with CD6 include anus cancer, and horner's syndrome. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is LOXL2.

UniProtKB/Swiss-Prot: CD6_HUMAN, P30203
Function: Involved in cell adhesion. Binds to CD166

Gene Wiki entry for CD6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD6 gene promoter:
         AML1a   AP-1   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

CD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060743:  view genomic region     (about GC identifiers)

Start:
60,739,115 bp from pter      End:
60,787,849 bp from pter
Size:
48,735 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD6_HUMAN, P30203 (See protein sequence)
Recommended Name: T-cell differentiation antigen CD6 precursor  
Size: 668 amino acids; 71801 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9UMF2 Q9Y4K7 Q9Y4K8 Q9Y4K9 Q9Y4L0
Alternative splicing: 5 isoforms:  P30203-1   P30203-2   P30203-3   P30203-4   P30203-5   

Explore the universe of human proteins at neXtProt for CD6: NX_P30203

Explore proteomics data for CD6 at MOPED 

Post-translational modifications:

  • UniProtKB: After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues
  • UniProtKB: Contains intrachain disulfide bond(s)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30203

  • CD6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001241679.1  NP_001241680.1  NP_006716.3  

    ENSEMBL proteins: 
     ENSP00000323280   ENSP00000443748   ENSP00000340334   ENSP00000440055   ENSP00000410638  
     ENSP00000390676   ENSP00000340628   ENSP00000443747   ENSP00000344108   ENSP00000345566  

    Human Recombinant Protein Products for CD6: 
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    Novus Biologicals CD6 Proteins
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    Sino Biological Recombinant Protein for CD6
    Sino Biological Cell Lysate for CD6 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS1919444
    GO:0009986cell surface IDA12493773
    GO:0016020membrane ----

    CD6 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CD6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    2 InterPro protein domains:
     IPR001190 Srcr_rcpt
     IPR017448 Srcr_rcpt-rel

    Graphical View of Domain Structure for InterPro Entry P30203

    ProtoNet protein and cluster: P30203

    1 Blocks protein domain: IPB001190 Speract/scavenger receptor

    UniProtKB/Swiss-Prot: CD6_HUMAN, P30203
    Similarity: Contains 3 SRCR domains


    CD6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD6_HUMAN, P30203
    Function: Involved in cell adhesion. Binds to CD166

         Genatlas biochemistry entry for CD6:
    cell differentiation antigen CD6,100kDa,identified by monoclonal antibodies M-T502,M-T606-M-T603,SPVL14,expressed
    on mature T-cell,B-cell subset,thymocyte

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding ----
         
    CD6 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for CD6):
        Cell adhesion molecules (CAMs)


    CD6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for CD6 (P302032, 3 ENSP000003232804) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SDCBPO005602, 3, ENSP000002601304MINT-62377 MINT-62376 I2D: score=3 STRING: ENSP00000260130
    CD5P061273, ENSP000003426814I2D: score=3 STRING: ENSP00000342681
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    ALCAMQ137403, ENSP000003059884I2D: score=3 STRING: ENSP00000305988
    GYG1ENSP000003407364STRING: ENSP00000340736
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    CD6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD6

    1 Novoseek inferred chemical compound relationship for CD6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 4.75 2 16914752 (1), 16818773 (1)

    Search CenterWatch for drugs/clinical trials and news about CD6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD6 gene (3 alternative transcripts): 
    NM_001254750.1  NM_001254751.1  NM_006725.4  

    Unigene Cluster for CD6:

    CD6 molecule
    Hs.744366  [show with all ESTs]
    Unigene Representative Sequence: AL832261
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313421(uc001nqp.3 uc001nqq.3 uc001nqs.3 uc001nqt.3)
    ENST00000542254 ENST00000545105 ENST00000344931 ENST00000545320 ENST00000542157
    ENST00000433107 ENST00000452451 ENST00000352009 ENST00000538288 ENST00000541964
    ENST00000538611 ENST00000419282 ENST00000505761 ENST00000344028(uc001nqr.3)
    ENST00000346437(uc009yni.3 uc009ynj.3)
    miRNA
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    hsa-miR-216a
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    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD6
    Clone
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    OriGene qSTAR qPCR primer pairs in human, mouse for CD6
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD6

    Additional mRNA sequence: 

    AK126159.1 AK128419.1 AK292704.1 AK312749.1 AL832261.1 AL832716.1 BC033755.1 BC078669.1 
    DQ786329.1 DQ786330.1 NR_045638.1 U66142.1 U66145.1 U66146.1 

    14 DOTS entries:

    DT.91682659  DT.91682653  DT.410855  DT.95239380  DT.101982902  DT.75102737  DT.97787060  DT.120716093 
    DT.120716183  DT.40200555  DT.86840915  DT.91889631  DT.100754820  DT.99965586 

    24/59 AceView cDNA sequences (see all 59):

    AI796386 AW134823 U66142 AW170766 U66145 AI797603 AW276242 BQ932452 
    AK128419 AL602263 AI653403 AW769890 AK126159 AL832261 U66146 BC033755 
    X60992 BP368108 AI336940 BG231800 BV204240 BX424272 BG058588 AI610613 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for CD6 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^
    SP1:                    -     -     -     -                             -                                                           -     -                     
    SP2:                    -     -     -     -                             -                                                           -     -                     
    SP3:                    -     -     -     -                             -                                                           -     -                     
    SP4:                    -     -     -     -                             -                                               -           -     -                     
    SP5:                    -     -     -     -                             -                                               -     -     -     -                     

    ExUns: 18a · 18b ^ 19a · 19b · 19c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:  -     -                     
    SP5:  -     -                     


    ECgene alternative splicing isoforms for CD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD6 expression in normal human tissues (normalized intensities)      CD6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCAGACC
    CD6 Expression
    About this image


    CD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 10 entries
             Double Positive Thymocytes Thymus
             Peripheral blood Pan-T Cells   
             neutrophils   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Cord Blood CD133- Cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   

    See CD6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD6

    SOURCE GeneReport for Unigene cluster: Hs.744366

    UniProtKB/Swiss-Prot: CD6_HUMAN, P30203
    Tissue specificity: Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some
    cells in the brain

        SABiosciences Expression via Pathway-Focused PCR Array including CD6: 
              Cell Surface Markers in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CD6 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd61 , 5 CD6 antigen1, 5 76.92(n)1
    70.74(a)1
      19 (7.16 cM)5
    125111  NM_009852.31  NP_033982.31 
     107893415 
    chicken
    (Gallus gallus)
    Aves --
    --
    8(a)
    possible ortholog
    AADN03013081.1(2463-5190)
    lizard
    (Anolis carolinensis)
    Reptilia CD66
    Uncharacterized protein
    31(a)
    1 ↔ 1
    GL343235.1(474437-531447)
    zebrafish
    (Danio rerio)
    Actinopterygii CD66
    si:ch211-150o23.36
    si:ch211-150o23.3
    13(a)
    11(a)
    1 ↔ 1
    possible ortholog
    16(43020334-43052120)
    8(18294647-18304123)
    fruit fly
    (Drosophila melanogaster)
    Insecta lox6
    lysyl oxidase-like
    9(a)
    possible ortholog
    3R(27284102-27285591)


    ENSEMBL Gene Tree for CD6 (if available)
    TreeFam Gene Tree for CD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD6 gene
    LOXL22  CD163L12  LOXL42  CD1632  LOXL32  SSC5D2  PRSS122  CD5L2  
    LOX2  SRCRB4D2  LOXL12  DMBT12  
    8 SIMAP similar genes for CD6 using alignment to 16 protein entries:     CD6_HUMAN (see all proteins):
    LGALS3BP    LOXL2    LOXL3    DMBT1    CD5L    CD163
    SSC5D    CD163L1

    CD6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1196 SNPs in CD6 are shown (see all 1196)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915028511,2
    --60737240(+) TTTTGC/TTTCTC 4 -- us2k10--------
    rs1140388691,2
    C,F--60737265(+) TCCATG/ATTCAT 4 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1494704821,2
    --60737365(+) TATACA/CAGGTC 4 -- us2k10--------
    rs1441342741,2
    C--60737625(+) AAGATA/GGTTTA 4 -- us2k10--------
    rs1825699991,2
    C--60737650(+) TGTTTC/TGTATT 4 -- us2k10--------
    rs772986611,2
    F--60737720(+) TTCCCG/AGCCCA 4 -- us2k11Minor allele frequency- A:0.05NA 120
    rs1486801731,2
    --60737742(+) TTCCTC/TTTAGG 4 -- us2k10--------
    rs1422318141,2
    --60737759(+) AGACCC/TCACAT 4 -- us2k10--------
    rs29056931,2
    C,F,H--60737857(-) GGAAGC/TGAAAG 4 -- us2k129Minor allele frequency- T:0.03NS EA NA WA CSA 2204
    rs1507625661,2
    --60737923(+) ATCTGA/GGAGCT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD6 (60739115 - 60787849 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1472305CNV Insertion17803354
    nsv39214CNV Insertion16902084
    nsv468580CNV Loss19166990


    Human Gene Mutation Database (HGMD): CD6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD6
    DNA2.0 Custom Variant and Variant Library Synthesis for CD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 186720    OMIM disorders: --

    16 diseases for CD6:    About MalaCards
    anus cancer    horner's syndrome    multiple sclerosis    nasopharynx carcinoma
    proctitis    tongue cancer    b-cell chronic lymphocytic leukemia    graft versus host disease
    oral cancer    inflammatory bowel disease    chronic lymphocytic leukemia    hepatitis b
    rheumatoid arthritis    hepatitis    arthritis    leukemia

    6 diseases from the University of Copenhagen DISEASES database for CD6:
    Carcinoma     Prostate cancer     Oropharynx cancer     Breast cancer
    Tongue cancer     Horner's syndrome

    CD6 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CD6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    graft-versus-host disease 42.6 1 1750063 (1)
    tumors 0 6 16818742 (2)

    Genetic Association Database (GAD): CD6
    Human Genome Epidemiology (HuGE) Navigator: CD6 (8 documents)

    Export disorders for CD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD6 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with CD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms. (PubMed id 9013954)1, 2, 3 Bowen M.A.... Aruffo A. (1997)
    2. Validation of the CD6 and TNFRSF1A loci as risk facto rs for multiple sclerosis in Spain. (PubMed id 20430450)1, 4 Swaminathan B....Vandenbroeck K. (2010)
    3. Meta-analysis of genome scans and replication identif y CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (PubMed id 19525953)1, 4 De Jager P.L.... J.R. (2009)
    4. Multiple sclerosis susceptibility alleles in African Americans. (PubMed id 19865102)1, 4 Johnson B.A....Oksenberg J.R. (2009)
    5. Integration of genetic risk factors into a clinical a lgorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PubMed id 19879194)1, 4 De Jager P.L.... E.W. (2009)
    6. Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors. (PubMed id 7678115)1, 2 Wee S....Aruffo A. (1993)
    7. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. (PubMed id 1919444)1, 2 Aruffo A.... Seed B. (1991)
    8. Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule. (PubMed id 2016320)1, 2 Swack J.A.... Rudd C.E. (1991)
    9. Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. (PubMed id 17371992)1, 9 Castro M.A....Carmo A.M. (2007)
    10. CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. (PubMed id 16914752)1, 9 Hassan N.J....Brown M.H. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 923 HGNC: 1691 AceView: CD6 Ensembl:ENSG00000013725 euGenes: HUgn923
    ECgene: CD6 Kegg: 923 H-InvDB: CD6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD6 gene:
    Search GeneIP for patents involving CD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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