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Aliases for CD6 Gene

Aliases for CD6 Gene

  • CD6 Molecule 2 3 5
  • CD6 Antigen 2 3 4
  • TP120 3 4
  • T12 3 4

External Ids for CD6 Gene

Previous GeneCards Identifiers for CD6 Gene

  • GC11P063132
  • GC11P062252
  • GC11P060514
  • GC11P060495
  • GC11P060743
  • GC11P057086

Summaries for CD6 Gene

Entrez Gene Summary for CD6 Gene

  • This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for CD6 Gene

CD6 (CD6 Molecule) is a Protein Coding gene. Diseases associated with CD6 include bronchus cancer and epidural neoplasm. Among its related pathways are Cell adhesion molecules (CAMs). GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is SSC4D.

UniProtKB/Swiss-Prot for CD6 Gene

  • Cell adhesion molecule that mediates cell-cell contacts and regulates T cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).

Gene Wiki entry for CD6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD6 Gene

Genomics for CD6 Gene

Regulatory Elements for CD6 Gene

Promoters for CD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD6 Gene

Chromosome:
11
Start:
60,971,641 bp from pter
End:
61,020,377 bp from pter
Size:
48,737 bases
Orientation:
Plus strand

Genomic View for CD6 Gene

Genes around CD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD6 Gene

Proteins for CD6 Gene

  • Protein details for CD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30203-CD6_HUMAN
    Recommended name:
    T-cell differentiation antigen CD6
    Protein Accession:
    P30203
    Secondary Accessions:
    • A4KAD4
    • A4KAD5
    • Q9UMF2
    • Q9Y4K7
    • Q9Y4K8
    • Q9Y4K9
    • Q9Y4L0

    Protein attributes for CD6 Gene

    Size:
    668 amino acids
    Molecular mass:
    71801 Da
    Quaternary structure:
    • Interacts (via extracellular domain) with ALCAM/CD166 (via extracellular domain) (PubMed:15048703, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:26146185). Interacts with the TCR/CD3 complex subunit CD3E (PubMed:15294938). Interacts (via tyrosine phosphorylated C-terminus) with LCP2 (via SH2 domain) (PubMed:16914752). Interacts with VAV1 (By similarity). Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3 (PubMed:24945728). Interaction with LGALS1 or LGALS3 inhibits interaction with ALCAM (PubMed:24945728).

    Three dimensional structures from OCA and Proteopedia for CD6 Gene

    Alternative splice isoforms for CD6 Gene

neXtProt entry for CD6 Gene

Proteomics data for CD6 Gene at MOPED

Post-translational modifications for CD6 Gene

  • After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
  • Glycosylated.
  • Glycosylation at Asn 28, Asn 49, Asn 112, Asn 118, Asn 229, Asn 339, Asn 345, and Asn 368
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CD6 Gene

Domains & Families for CD6 Gene

Gene Families for CD6 Gene

Protein Domains for CD6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD6 Gene

Graphical View of Domain Structure for InterPro Entry

P30203

UniProtKB/Swiss-Prot:

CD6_HUMAN :
  • Contains 3 SRCR domains.
Domain:
  • Contains 3 SRCR domains.
genes like me logo Genes that share domains with CD6: view

Function for CD6 Gene

Molecular function for CD6 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD6,100kDa,identified by monoclonal antibodies M-T502,M-T606-M-T603,SPVL14,expressed on mature T-cell,B-cell subset,thymocyte
UniProtKB/Swiss-Prot Function:
Cell adhesion molecule that mediates cell-cell contacts and regulates T cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).
genes like me logo Genes that share phenotypes with CD6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD6 Gene

Localization for CD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD6 Gene

Cell membrane; Single-pass type I membrane protein. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938). {ECO:0000269 PubMed:15294938}.
Soluble CD6: Secreted. Note=The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD6 Gene COMPARTMENTS Subcellular localization image for CD6 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031226 intrinsic component of plasma membrane IDA 15294938
genes like me logo Genes that share ontologies with CD6: view

Pathways & Interactions for CD6 Gene

genes like me logo Genes that share pathways with CD6: view

Pathways by source for CD6 Gene

1 KEGG pathway for CD6 Gene

Gene Ontology (GO) - Biological Process for CD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002438 acute inflammatory response to antigenic stimulus IDA 17601777
GO:0006898 receptor-mediated endocytosis IEA --
GO:0031663 lipopolysaccharide-mediated signaling pathway IDA 17601777
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with CD6: view

No data available for SIGNOR curated interactions for CD6 Gene

Drugs & Compounds for CD6 Gene

(1) Drugs for CD6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CD6: view

Transcripts for CD6 Gene

Unigene Clusters for CD6 Gene

CD6 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:
SP15:

ExUns: 18a · 18b ^ 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4: - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CD6 Gene

GeneLoc Exon Structure for
CD6
ECgene alternative splicing isoforms for
CD6

Expression for CD6 Gene

mRNA expression in normal human tissues for CD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD6 Gene

This gene is overexpressed in Whole Blood (x20.8), Spleen (x7.4), and Small Intestine - Terminal Ileum (x5.9).

Protein differential expression in normal tissues from HIPED for CD6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.1), Lymph node (15.3), CD4 Tcells (14.5), and Tlymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD6 Gene



SOURCE GeneReport for Unigene cluster for CD6 Gene Hs.744366

mRNA Expression by UniProt/SwissProt for CD6 Gene

P30203-CD6_HUMAN
Tissue specificity: Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.
genes like me logo Genes that share expression patterns with CD6: view

Protein tissue co-expression partners for CD6 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD6 36
  • 99 (a)
OneToOne
CD6 35
  • 99.05 (n)
  • 98.5 (a)
cow
(Bos Taurus)
Mammalia CD6 35
  • 80.69 (n)
  • 71.71 (a)
CD6 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD6 36
  • 75 (a)
OneToOne
CD6 35
  • 82.14 (n)
  • 76.35 (a)
mouse
(Mus musculus)
Mammalia Cd6 16
Cd6 36
  • 70 (a)
OneToOne
Cd6 35
  • 76.9 (n)
  • 70.68 (a)
oppossum
(Monodelphis domestica)
Mammalia CD6 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD6 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd6 35
  • 77.06 (n)
  • 71.6 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 12 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CD6 36
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497305 35
  • 49.33 (n)
  • 40.27 (a)
zebrafish
(Danio rerio)
Actinopterygii CD6 (1 of 2) 36
  • 13 (a)
OneToMany
CD6 (2 of 2) 36
  • 24 (a)
OneToMany
Species with no ortholog for CD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD6 Gene

ENSEMBL:
Gene Tree for CD6 (if available)
TreeFam:
Gene Tree for CD6 (if available)

Paralogs for CD6 Gene

Paralogs for CD6 Gene

genes like me logo Genes that share paralogs with CD6: view

Variants for CD6 Gene

Sequence variations from dbSNP and Humsavar for CD6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_057202 -
VAR_057203 -
VAR_057204 -
rs2074233 - 61,017,992(+) TGGCC(A/G)GCACC nc-transcript-variant, reference, missense
VAR_059809 -

Structural Variations from Database of Genomic Variants (DGV) for CD6 Gene

Variant ID Type Subtype PubMed ID
esv1472305 CNV Insertion 17803354
nsv39214 CNV Insertion 16902084
nsv468580 CNV Loss 19166990

Variation tolerance for CD6 Gene

Residual Variation Intolerance Score: 21.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.95; 93.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD6 Gene

HapMap Linkage Disequilibrium report
CD6
Human Gene Mutation Database (HGMD)
CD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD6 Gene

Disorders for CD6 Gene

MalaCards: The human disease database

(19) MalaCards diseases for CD6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bronchus cancer
  • malignant neoplasm of bronchus and lung, unspecified
epidural neoplasm
  • extradural tumor
lower lip cancer
breast abscess
  • abscess of breast
oropharynx cancer
  • malignant neoplasm of junctional region of oropharynx
- elite association - COSMIC cancer census association via MalaCards
Search CD6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD6

Genetic Association Database (GAD)
CD6
Human Genome Epidemiology (HuGE) Navigator
CD6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD6
genes like me logo Genes that share disorders with CD6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD6 Gene

Publications for CD6 Gene

  1. Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms. (PMID: 9013954) Bowen M.A. … Aruffo A. (J. Immunol. 1997) 2 3 4 67
  2. Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. (PMID: 17371992) Castro M.A. … Carmo A.M. (J. Immunol. 2007) 3 23
  3. Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens. (PMID: 16818742) Kato Y. … Minato N. (J. Immunol. 2006) 3 23
  4. Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor. (PMID: 16818773) IbA!A+ez A. … Lozano F. (J. Immunol. 2006) 3 23
  5. CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. (PMID: 16914752) Hassan N.J. … Brown M.H. (Mol. Cell. Biol. 2006) 3 23

Products for CD6 Gene

Sources for CD6 Gene

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