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Aliases for CD6 Gene

Aliases for CD6 Gene

  • CD6 Molecule 2 3
  • CD6 Antigen 2 3 4
  • TP120 3 4 6
  • T12 3 4
  • T-Cell Differentiation Antigen CD6 3

External Ids for CD6 Gene

Previous GeneCards Identifiers for CD6 Gene

  • GC11P063132
  • GC11P062252
  • GC11P060514
  • GC11P060495
  • GC11P060743
  • GC11P057086

Summaries for CD6 Gene

Entrez Gene Summary for CD6 Gene

  • This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for CD6 Gene

CD6 (CD6 Molecule) is a Protein Coding gene. Diseases associated with CD6 include oropharynx cancer. Among its related pathways are Cell adhesion molecules (CAMs). GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is LOXL1.

UniProtKB/Swiss-Prot for CD6 Gene

  • Involved in cell adhesion. Binds to CD166

Gene Wiki entry for CD6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD6 Gene

Genomics for CD6 Gene

Regulatory Elements for CD6 Gene

Genomic Location for CD6 Gene

60,971,641 bp from pter
61,020,377 bp from pter
48,737 bases
Plus strand

Genomic View for CD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD6 Gene

Proteins for CD6 Gene

  • Protein details for CD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell differentiation antigen CD6
    Protein Accession:
    Secondary Accessions:
    • A4KAD4
    • A4KAD5
    • Q9UMF2
    • Q9Y4K7
    • Q9Y4K8
    • Q9Y4K9
    • Q9Y4L0

    Protein attributes for CD6 Gene

    668 amino acids
    Molecular mass:
    71801 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD6 Gene

neXtProt entry for CD6 Gene

Proteomics data for CD6 Gene at MOPED

Post-translational modifications for CD6 Gene

  • After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
  • Glycosylation at Asn28, Asn49, Asn112, Asn118, Asn229, Asn339, Asn345, and Asn368
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CD6 Gene

Domains for CD6 Gene

Gene Families for CD6 Gene

  • CD :CD molecules

Protein Domains for CD6 Gene


Suggested Antigen Peptide Sequences for CD6 Gene

Graphical View of Domain Structure for InterPro Entry



  • P30203
  • Contains 3 SRCR domains.
genes like me logo Genes that share domains with CD6: view

Function for CD6 Gene

Molecular function for CD6 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD6,100kDa,identified by monoclonal antibodies M-T502,M-T606-M-T603,SPVL14,expressed on mature T-cell,B-cell subset,thymocyte
UniProtKB/Swiss-Prot Function:
Involved in cell adhesion. Binds to CD166

Gene Ontology (GO) - Molecular Function for CD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IPI 24945728
genes like me logo Genes that share ontologies with CD6: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CD6 Gene

Localization for CD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD6 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD6 Gene COMPARTMENTS Subcellular localization image for CD6 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 1919444
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CD6: view

Pathways for CD6 Gene

genes like me logo Genes that share pathways with CD6: view

Pathways by source for CD6 Gene

1 KEGG pathway for CD6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CD6: view

Compounds for CD6 Gene

(1) Novoseek inferred chemical compound relationships for CD6 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 4.75 2
genes like me logo Genes that share compounds with CD6: view

Transcripts for CD6 Gene

Unigene Clusters for CD6 Gene

CD6 molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - -
SP9: - -
SP10: - - -
SP11: -

ExUns: 18a · 18b ^ 19a · 19b · 19c
SP4: - -
SP5: - -
SP6: - -

Relevant External Links for CD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD6 Gene

mRNA expression in normal human tissues for CD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD6 Gene

This gene is overexpressed in Whole Blood (20.8), Spleen (7.4), and Small Intestine - Terminal Ileum (5.9).

Protein differential expression in normal tissues for CD6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.1), Lymph node (15.3), CD4 Tcells (14.5), and Tlymphocyte (6.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD6 Gene

SOURCE GeneReport for Unigene cluster for CD6 Gene Hs.744366

mRNA Expression by UniProt/SwissProt for CD6 Gene

Tissue specificity: Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain
genes like me logo Genes that share expressions with CD6: view

Expression partners for CD6 Gene

In Situ Assay Products

Orthologs for CD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD6 35
  • 80.69 (n)
  • 71.71 (a)
CD6 36
  • 72 (a)
(Canis familiaris)
Mammalia CD6 35
  • 82.14 (n)
  • 76.35 (a)
CD6 36
  • 75 (a)
(Mus musculus)
Mammalia Cd6 35
  • 76.9 (n)
  • 70.68 (a)
Cd6 16
Cd6 36
  • 70 (a)
(Pan troglodytes)
Mammalia CD6 35
  • 99.05 (n)
  • 98.5 (a)
CD6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cd6 35
  • 77.06 (n)
  • 71.6 (a)
(Monodelphis domestica)
Mammalia CD6 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia CD6 36
  • 51 (a)
(Gallus gallus)
Aves -- 36
  • 12 (a)
-- 36
  • 23 (a)
(Anolis carolinensis)
Reptilia CD6 36
  • 33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497305 35
  • 49.33 (n)
  • 40.27 (a)
(Danio rerio)
Actinopterygii CD6 (1 of 2) 36
  • 13 (a)
CD6 (2 of 2) 36
  • 24 (a)
Species with no ortholog for CD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD6 Gene

Gene Tree for CD6 (if available)
Gene Tree for CD6 (if available)

Paralogs for CD6 Gene

genes like me logo Genes that share paralogs with CD6: view

Variants for CD6 Gene

Sequence variations from dbSNP and Humsavar for CD6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs540513 -- 60,998,848(+) AAGGC(A/C)GAAAA intron-variant
rs540515 -- 60,998,850(+) GGCAG(A/G)AAAAA intron-variant
rs598206 -- 61,011,657(+) gctcc(A/G)aggct intron-variant
rs659101 -- 60,991,555(+) CACAT(A/G)TTCAT intron-variant
rs916811 -- 60,996,360(+) TAGCT(A/G)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD6 Gene

Variant ID Type Subtype PubMed ID
esv1472305 CNV Insertion 17803354
nsv39214 CNV Insertion 16902084
nsv468580 CNV Loss 19166990

Relevant External Links for CD6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD6 Gene

Disorders for CD6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CD6 Gene in MalaCards »

(1) Diseases for CD6 Gene including...

(2) Novoseek inferred disease relationships for CD6 Gene

Disease -log(P) Hits PubMed IDs
graft-versus-host disease 42.6 1
tumors 0 2

Relevant External Links for CD6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD6: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CD6 Gene

Publications for CD6 Gene

  1. Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. (PMID: 17371992) Castro M.A. … Carmo A.M. (J. Immunol. 2007) 3 4 23
  2. Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms. (PMID: 9013954) Bowen M.A. … Aruffo A. (J. Immunol. 1997) 2 3 4
  3. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (PMID: 19525953) De Jager P.L. … Oksenberg J.R. (Nat. Genet. 2009) 3 48
  4. Multiple sclerosis susceptibility alleles in African Americans. (PMID: 19865102) Johnson B.A. … Oksenberg J.R. (Genes Immun. 2010) 3 48
  5. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PMID: 19879194) De Jager P.L. … Karlson E.W. (Lancet Neurol 2009) 3 48

Products for CD6 Gene

Sources for CD6 Gene

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