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CD6 Gene

protein-coding   GIFtS: 60
GCID: GC11P060743

CD6 Molecule

(Previous name: CD6 antigen)
  See CD6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD6 Molecule1 2
CD6 Antigen1 2 3
TP1202 3 5
T122 3
T-Cell Differentiation Antigen CD62

External Ids:    HGNC: 16911   Entrez Gene: 9232   Ensembl: ENSG000000137257   OMIM: 1867205   UniProtKB: P302033   

Export aliases for CD6 gene to outside databases

Previous GC identifers: GC11P063132 GC11P062252 GC11P060990 GC11P060514 GC11P060495 GC11P057086


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD6 Gene:
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The
encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an
activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.
This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for CD6 Gene:
CD6 (CD6 molecule) is a protein-coding gene. Diseases associated with CD6 include oropharynx cancer, and multiple sclerosis. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is LOXL2.

UniProtKB/Swiss-Prot: CD6_HUMAN, P30203
Function: Involved in cell adhesion. Binds to CD166

Gene Wiki entry for CD6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CD6 gene promoter:
         AML1a   AP-1   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD6 promoter sequence
   Search Chromatin IP Primers for CD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

CD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060743:  view genomic region     (about GC identifiers)

Start:
60,739,115 bp from pter      End:
60,787,849 bp from pter
Size:
48,735 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CD6_HUMAN, P30203 (See protein sequence)
Recommended Name: T-cell differentiation antigen CD6 precursor  
Size: 668 amino acids; 71801 Da
Secondary accessions: Q9UMF2 Q9Y4K7 Q9Y4K8 Q9Y4K9 Q9Y4L0
Alternative splicing: 5 isoforms:  P30203-1   P30203-2   P30203-3   P30203-4   P30203-5   

Explore the universe of human proteins at neXtProt for CD6: NX_P30203

Explore proteomics data for CD6 at MOPED

Post-translational modifications: 

  • After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues1
  • Contains intrachain disulfide bond(s)1
  • Glycosylation2 at Asn28, Asn49, Asn112, Asn118, Asn229, Asn339, Asn345, Asn368
  • Modification sites at PhosphoSitePlus

  • See CD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001241679.1  NP_001241680.1  NP_006716.3  

    ENSEMBL proteins: 
     ENSP00000323280   ENSP00000443748   ENSP00000340334   ENSP00000440055   ENSP00000410638  
     ENSP00000390676   ENSP00000340628   ENSP00000443747   ENSP00000344108   ENSP00000345566  

    CD6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CD6

     
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    antibodies-online proteins for CD6 (5 products) 

     
    antibodies-online peptides for CD6

    CD6 Antibody Products:

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    antibodies-online antibodies for CD6 (136 products) 

    CD6 Assay Products:

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    antibodies-online kits for CD6 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    2 InterPro protein domains:
     IPR001190 SRCR
     IPR017448 Srcr_rcpt-rel

    Graphical View of Domain Structure for InterPro Entry P30203

    ProtoNet protein and cluster: P30203

    1 Blocks protein domain: IPB001190 Speract/scavenger receptor

    UniProtKB/Swiss-Prot: CD6_HUMAN, P30203
    Similarity: Contains 3 SRCR domains


    Find genes that share domains with CD6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD6_HUMAN, P30203
    Function: Involved in cell adhesion. Binds to CD166

         Genatlas biochemistry entry for CD6:
    cell differentiation antigen CD6,100kDa,identified by monoclonal antibodies M-T502,M-T606-M-T603,SPVL14,expressed
    on mature T-cell,B-cell subset,thymocyte

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CD6           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CD6

    miRNA
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    hsa-miR-216a
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD6

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13484) for CD6 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD6_HUMAN, P30203: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    nucleus2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS1919444
    GO:0016020membrane ----

    Find genes that share ontologies with CD6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD6 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with CD6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for CD6):
        Cell adhesion molecules (CAMs)

        Pathway & Disease-focused RT2 Profiler PCR Array including CD6: 
              Cell Surface Markers in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CD6 (P302032, 3 ENSP000003232804) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SDCBPO005602, 3, ENSP000002601304MINT-62377 MINT-62376 I2D: score=3 STRING: ENSP00000260130
    CD5P061273, ENSP000003426814I2D: score=3 STRING: ENSP00000342681
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    ALCAMQ137403, ENSP000003059884I2D: score=3 STRING: ENSP00000305988
    GYG1ENSP000003407364STRING: ENSP00000340736
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with CD6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD6

    1 Novoseek inferred chemical compound relationship for CD6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 4.75 2 16914752 (1), 16818773 (1)



    Find genes that share compounds with CD6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD6 gene (3 alternative transcripts): 
    NM_001254750.1  NM_001254751.1  NM_006725.4  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313421(uc001nqp.3 uc001nqq.3 uc001nqs.3 uc001nqt.3)
    ENST00000542254 ENST00000545105 ENST00000344931 ENST00000545320 ENST00000542157
    ENST00000433107 ENST00000452451 ENST00000352009 ENST00000538288 ENST00000541964
    ENST00000538611 ENST00000419282 ENST00000505761 ENST00000344028(uc001nqr.3)
    ENST00000346437(uc009yni.3 uc009ynj.3)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CD6:
    hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidCD6 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CD6
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-13484) for CD6 

    Selected AceView cDNA sequences (see all 59):

    AI797603 BQ932452 AI796386 U66145 AK126159 BC033755 AW134823 AW170766 
    AW276242 U66146 AL832261 AI653403 AW769890 U66142 X60992 AK128419 
    AL602263 AI610613 BG058588 BG231800 BX424272 BM922699 AI568230 BP368108 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD6 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^
    SP1:                    -     -     -     -                             -                                                           -     -                     
    SP2:                    -     -     -     -                             -                                                           -     -                     
    SP3:                    -     -     -     -                             -                                                           -     -                     
    SP4:                    -     -     -     -                             -                                               -           -     -                     
    SP5:                    -     -     -     -                             -                                               -     -     -     -                     

    ExUns: 18a · 18b ^ 19a · 19b · 19c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:  -     -                     
    SP5:  -     -                     


    ECgene alternative splicing isoforms for CD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCAGACC
    CD6 Expression
    About this image


    CD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
    CD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD6 Protein Expression

    UniProtKB/Swiss-Prot: CD6_HUMAN, P30203
    Tissue specificity: Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some
    cells in the brain

        Pathway & Disease-focused RT2 Profiler PCR Array including CD6: 
              Cell Surface Markers in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD6 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd61 , 5 CD6 antigen1, 5 76.9(n)1
    70.68(a)1
      19 (7.16 cM)5
    125111  NM_009852.31  NP_033982.31 
     107893415 
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    23(a)
    12(a)
    1 ↔ many
    1 ↔ many
    5(16196911-16205393) ENSGALG00000028071
    5(16165089-16180665) ENSGALG00000010831
    lizard
    (Anolis carolinensis)
    Reptilia CD66
    CD6 molecule
    33(a)
    1 ↔ 1
    GL343235.1(474437-531447)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004973051 T-cell differentiation antigen CD6-like 49.33(n)
    40.27(a)
      100497305  XM_002944247.2  XP_002944293.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CD6 (2 of 2)6
    CD6 (1 of 2)6
    CD6 molecule
    24(a)
    13(a)
    1 ↔ many
    1 ↔ many
    4(10143582-10146485) ENSDARG00000096047
    8(18294647-18304123) ENSDARG00000078502


    ENSEMBL Gene Tree for CD6 (if available)
    TreeFam Gene Tree for CD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD6 gene
    LOXL22  CD163L12  LOXL42  CD1632  LOXL32  SSC5D2  PRSS122  CD5L2  
    LOX2  SRCRB4D2  LOXL12  DMBT12  
    8 SIMAP similar genes for CD6 using alignment to 16 protein entries:     CD6_HUMAN (see all proteins):
    LGALS3BP    LOXL2    LOXL3    DMBT1    CD5L    CD163
    SSC5D    CD163L1

    Find genes that share paralogs with CD6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD6 (see all 1196)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915028511,2
    --60737240(+) TTTTGC/TTTCTC 4 -- us2k10--------
    rs1140388691,2
    C,F--60737265(+) TCCATG/ATTCAT 4 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1494704821,2
    --60737365(+) TATACA/CAGGTC 4 -- us2k10--------
    rs1441342741,2
    C--60737625(+) AAGATA/GGTTTA 4 -- us2k10--------
    rs1825699991,2
    C--60737650(+) TGTTTC/TGTATT 4 -- us2k10--------
    rs772986611,2
    F--60737720(+) TTCCCG/AGCCCA 4 -- us2k11Minor allele frequency- A:0.05NA 120
    rs1486801731,2
    --60737742(+) TTCCTC/TTTAGG 4 -- us2k10--------
    rs1422318141,2
    --60737759(+) AGACCC/TCACAT 4 -- us2k10--------
    rs29056931,2
    C,F,H--60737857(-) GGAAGC/TGAAAG 4 -- us2k129Minor allele frequency- T:0.03NS EA NA WA CSA 2204
    rs1507625661,2
    --60737923(+) ATCTGA/GGAGCT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD6 (60739115 - 60787849 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1472305CNV Insertion17803354
    nsv39214CNV Insertion16902084
    nsv468580CNV Loss19166990

    Human Gene Mutation Database (HGMD): CD6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD6
    DNA2.0 Custom Variant and Variant Library Synthesis for CD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186720    OMIM disorders: --

    2 diseases for CD6:    
    About MalaCards
    oropharynx cancer    multiple sclerosis

    6 diseases from the University of Copenhagen DISEASES database for CD6:
    Carcinoma     Prostate cancer     Oropharynx cancer     Breast cancer
    Tongue cancer     Horner's syndrome

    Find genes that share disorders with CD6           About GenesLikeMe

    2 Novoseek inferred disease relationships for CD6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    graft-versus-host disease 42.6 1 1750063 (1)
    tumors 0 6 16818742 (2)

    Genetic Association Database (GAD): CD6
    Human Genome Epidemiology (HuGE) Navigator: CD6 (8 documents)

    Export disorders for CD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD6 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with CD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms. (PubMed id 9013954)1, 2, 3 Bowen M.A.... Aruffo A. (J. Immunol. 1997)
    2. Multiple sclerosis susceptibility alleles in African Americans. (PubMed id 19865102)1, 4 Johnson B.A....Oksenberg J.R. (Genes Immun. 2010)
    3. Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain. (PubMed id 20430450)1, 4 Swaminathan B....Vandenbroeck K. (J. Neuroimmunol. 2010)
    4. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (PubMed id 19525953)1, 4 De Jager P.L....Oksenberg J.R. (Nat. Genet. 2009)
    5. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PubMed id 19879194)1, 4 De Jager P.L....Karlson E.W. (Lancet Neurol 2009)
    6. Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors. (PubMed id 7678115)1, 2 Wee S....Aruffo A. (J. Exp. Med. 1993)
    7. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. (PubMed id 1919444)1, 2 Aruffo A.... Seed B. (J. Exp. Med. 1991)
    8. Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule. (PubMed id 2016320)1, 2 Swack J.A.... Rudd C.E. (J. Biol. Chem. 1991)
    9. Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. (PubMed id 17371992)1, 9 Castro M.A....Carmo A.M. (J. Immunol. 2007)
    10. CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. (PubMed id 16914752)1, 9 Hassan N.J....Brown M.H. (Mol. Cell. Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 923 HGNC: 1691 AceView: CD6 Ensembl:ENSG00000013725 euGenes: HUgn923
    ECgene: CD6 Kegg: 923 H-InvDB: CD6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CD6 gene:
    Search GeneIP for patents involving CD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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