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Aliases for CD5L Gene

Aliases for CD5L Gene

  • CD5 Molecule Like 2 3 5
  • CD5 Antigen-Like (Scavenger Receptor Cysteine Rich Family) 2 3
  • Apoptosis Inhibitor Expressed By Macrophages 3 4
  • IgM-Associated Peptide 3 4
  • Apoptosis Inhibitor 6 2 3
  • SP-ALPHA 3 4
  • API6 3 4
  • CT-2 3 4
  • HAIM 3 4
  • Apoptosis Inhibitor Of Macrophage 3
  • CD5 Molecule-Like 2
  • CD5 Antigen-Like 3
  • Spalpha 3
  • PRO229 3
  • AIM 3

External Ids for CD5L Gene

Previous HGNC Symbols for CD5L Gene

  • API6

Previous GeneCards Identifiers for CD5L Gene

  • GC01M155669
  • GC01M153577
  • GC01M154578
  • GC01M155017
  • GC01M155011
  • GC01M154613
  • GC01M156067
  • GC01M129158

Summaries for CD5L Gene

GeneCards Summary for CD5L Gene

CD5L (CD5 Molecule Like) is a Protein Coding gene. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is DMBT1.

UniProtKB/Swiss-Prot for CD5L Gene

  • Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).

Gene Wiki entry for CD5L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD5L Gene

Genomics for CD5L Gene

Regulatory Elements for CD5L Gene

Enhancers for CD5L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G157849 0.4 Ensembl 11.1 +48.6 48556 1.0 ZZZ3 SPI1 FCRL1 CD5L FCRL2 FCRL3 MRPS21P2
GH01G157944 0.4 Ensembl 11 -46.7 -46663 0.6 IKZF1 SPI1 CD5L KIRREL FCRL1 LOC105371458 LOC105371459
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD5L on UCSC Golden Path with GeneCards custom track

Genomic Location for CD5L Gene

Chromosome:
1
Start:
157,827,071 bp from pter
End:
157,898,256 bp from pter
Size:
71,186 bases
Orientation:
Minus strand

Genomic View for CD5L Gene

Genes around CD5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD5L Gene

Proteins for CD5L Gene

  • Protein details for CD5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43866-CD5L_HUMAN
    Recommended name:
    CD5 antigen-like
    Protein Accession:
    O43866
    Secondary Accessions:
    • A8K7M5
    • Q6UX63

    Protein attributes for CD5L Gene

    Size:
    347 amino acids
    Molecular mass:
    38088 Da
    Quaternary structure:
    • Interacts with FASN; the interaction is direct (By similarity). Interacts with IgM; protecting CD5L from renal excretion and leading to increased CD5L levels in circulating blood (PubMed:8034987, PubMed:24804991).

neXtProt entry for CD5L Gene

Post-translational modifications for CD5L Gene

  • Not N-glycosylated (PubMed:23236605). Probably not O-glycosylated (PubMed:23236605).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CD5L Gene

Antibody Products

  • Abcam antibodies for CD5L

Protein Products

No data available for DME Specific Peptides for CD5L Gene

Domains & Families for CD5L Gene

Protein Domains for CD5L Gene

Suggested Antigen Peptide Sequences for CD5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD5L: view

No data available for UniProtKB/Swiss-Prot for CD5L Gene

Function for CD5L Gene

Molecular function for CD5L Gene

GENATLAS Biochemistry:
CD5 antigen-like secreted protein alpha,expressed in lymphoid tissues,potential regulator of monocyte activation,function and/or survival
UniProtKB/Swiss-Prot Function:
Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).

Gene Ontology (GO) - Molecular Function for CD5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with CD5L: view
genes like me logo Genes that share phenotypes with CD5L: view

Animal Models for CD5L Gene

MGI Knock Outs for CD5L:

Animal Model Products

CRISPR Products

miRNA for CD5L Gene

miRTarBase miRNAs that target CD5L

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CD5L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD5L Gene

Localization for CD5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD5L Gene

Secreted. Cytoplasm. Note=Secreted by macrophages and circulates in the blood (PubMed:24223991, PubMed:24804991). Transported in the cytoplasm via CD36-mediated endocytosis (By similarity). {ECO:0000250 UniProtKB:Q9QWK4, ECO:0000269 PubMed:24223991, ECO:0000269 PubMed:24804991}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD5L gene
Compartment Confidence
extracellular 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for CD5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space TAS 9045627
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CD5L: view

Pathways & Interactions for CD5L Gene

No Data Available

Interacting Proteins for CD5L Gene

Gene Ontology (GO) - Biological Process for CD5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IEA --
GO:0006968 cellular defense response TAS 9045627
genes like me logo Genes that share ontologies with CD5L: view

No data available for Pathways by source and SIGNOR curated interactions for CD5L Gene

Drugs & Compounds for CD5L Gene

No Compound Related Data Available

Transcripts for CD5L Gene

Unigene Clusters for CD5L Gene

CD5 molecule-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CD5L

Alternative Splicing Database (ASD) splice patterns (SP) for CD5L Gene

No ASD Table

Relevant External Links for CD5L Gene

GeneLoc Exon Structure for
CD5L
ECgene alternative splicing isoforms for
CD5L

Expression for CD5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD5L Gene

This gene is overexpressed in Spleen (x50.5).

Protein differential expression in normal tissues from HIPED for CD5L Gene

This gene is overexpressed in Plasma (38.5) and Serum (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD5L Gene



Protein tissue co-expression partners for CD5L Gene

NURSA nuclear receptor signaling pathways regulating expression of CD5L Gene:

CD5L

SOURCE GeneReport for Unigene cluster for CD5L Gene:

Hs.134035

mRNA Expression by UniProt/SwissProt for CD5L Gene:

O43866-CD5L_HUMAN
Tissue specificity: Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues.

Evidence on tissue expression from TISSUES for CD5L Gene

  • Spleen(4.7)
  • Liver(4.4)
  • Pancreas(4.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with CD5L: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD5L Gene

Orthologs for CD5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD5L 34 35
  • 99.04 (n)
rat
(Rattus norvegicus)
Mammalia Cd5l 34
  • 76.67 (n)
dog
(Canis familiaris)
Mammalia CD5L 34 35
  • 76.33 (n)
mouse
(Mus musculus)
Mammalia Cd5l 34 16 35
  • 76.07 (n)
oppossum
(Monodelphis domestica)
Mammalia CD5L 35
  • 57 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD5L 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD5L 35
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD5L 35
  • 10 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-161n3.3 35
  • 8 (a)
ManyToMany
Species where no ortholog for CD5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD5L Gene

ENSEMBL:
Gene Tree for CD5L (if available)
TreeFam:
Gene Tree for CD5L (if available)

Paralogs for CD5L Gene

(6) SIMAP similar genes for CD5L Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CD5L Gene

genes like me logo Genes that share paralogs with CD5L: view

Variants for CD5L Gene

Sequence variations from dbSNP and Humsavar for CD5L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000005270 -- 157,835,376(+) TATCC(A/G)CCTGT intron-variant
rs1000101741 -- 157,835,123(+) AATAT(C/G)TCAGA intron-variant
rs1000246376 -- 157,841,266(+) TTATA(C/T)GAAAC intron-variant
rs1000330077 -- 157,830,192(+) CTCAC(A/G)TTTCA intron-variant
rs1000394000 -- 157,828,417(+) CCTCA(A/T)GTGCC intron-variant

Variation tolerance for CD5L Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD5L Gene

Disorders for CD5L Gene

Relevant External Links for CD5L

Genetic Association Database (GAD)
CD5L
Human Genome Epidemiology (HuGE) Navigator
CD5L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD5L

No disorders were found for CD5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD5L Gene

Publications for CD5L Gene

  1. Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins. (PMID: 9045627) Gebe J.A. … Aruffo A. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. IgM are associated to Spalpha (CD5 antigen-like). (PMID: 11981870) Tissot J.D. … Duchosal M.A. (Electrophoresis 2002) 3 4 22 64
  3. The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses. (PMID: 25713983) Sanjurjo L. … Sarrias M.R. (Autophagy 2015) 3 4 64
  4. Human scavenger protein AIM increases foam cell formation and CD36-mediated oxLDL uptake. (PMID: 24295828) AmAczaga N. … Sarrias M.R. (J. Leukoc. Biol. 2014) 3 4 64
  5. The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobial response against Mycobacterium tuberculosis by enhancing autophagy. (PMID: 24223991) Sanjurjo L. … Sarrias M.R. (PLoS ONE 2013) 3 4 64

Products for CD5L Gene

Sources for CD5L Gene

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