CD5L Gene
protein-coding GIFtS: 56
GCID: GC01M157800
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CD5 molecule-like(Previous names: apoptosis inhibitor 6, CD5 antigen-like (scavenger receptor...)
(Previous symbol: API6)
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Aliases
for CD5L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CD5 Molecule-Like1 2 | | CT-22 3 | | API61 2 3 | | AIM2 | | Spalpha1 2 | | PRO2292 | | Apoptosis Inhibitor 61 2 | | SP-ALPHA2 | | CD5 Antigen-Like (Scavenger Receptor Cysteine Rich Family)1 2 | | CD5 Antigen-Like2 | | IgM-Associated Peptide2 3 | | SP-Alpha1 |
Export aliases for CD5L gene to outside databasesPrevious GC identifers: GC01M155669 GC01M153577 GC01M154578 GC01M155017 GC01M155011 GC01M154613 GC01M156067 GC01M129158 |
Summaries
for CD5L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CD5L_HUMAN, O43866Function: May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis
Gene Wiki entry for CD5L
|
Genomic Views
for CD5L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CD5L gene promoter:
Evi-1 RORalpha1 Max PPAR-gamma1 FAC1 POU2F1 POU2F1a PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CD5L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD5L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21-q23 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q21-q23CD5L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M157800: view genomic region
(about GC identifiers)
Start:
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157,800,704 bp from pter |
End:
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157,868,046 bp from pter |
Size:
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67,343 bases |
Orientation:
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minus strand |
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Proteins
for CD5L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CD5L_HUMAN, O43866 (See
protein sequence)Recommended Name: CD5 antigen-like precursor Size: 347 amino acids; 38088 Da
Subunit: Associated with IgM
Subcellular location: Secreted
Secondary accessions: A8K7M5 Q6UX63Explore the universe of human proteins at neXtProt for CD5L: NX_O43866
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43866
CD5L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005885.1
ENSEMBL proteins: ENSP00000357156
Human Recombinant Protein Products for CD5L:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CD5L for ontologies About GeneDecksing
CD5L Antibody Products:
Assay Products for CD5L: |
Protein
Domains /
Families
for CD5L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CD5L for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43866ProtoNet protein and cluster: O43866 1 Blocks protein family: IPB001190 Speract/scavenger receptor
UniProtKB/Swiss-Prot: CD5L_HUMAN, O43866Similarity: Contains 3 SRCR domains |
Function
for CD5L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CD5L_HUMAN, O43866Function: May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis Genatlas biochemistry entry for CD5L:CD5 antigen-like secreted protein alpha,expressed in lymphoid tissues,potential regulator of monocyteactivation,function and/or survival
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005044 | scavenger receptor activity |
IEA | -- |
CD5L for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for CD5L:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cd5l):
CD5L for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Cd5ltm1Nto for CD5L
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD5L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD5L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD5L |
|
Pathways & Interactions
for CD5L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD5L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for CD5L (O438662, 3 ENSP000003571564) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
CD5L for ontologies About GeneDecksing
|
Drugs & Compounds
for CD5L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CD5L
Search CenterWatch for drugs/clinical trials and news about CD5L
|
Transcripts
for CD5L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CD5L gene: NM_005894.2 Unigene Cluster for CD5L: CD5 molecule-like Hs.134035 [show with all ESTs]Unigene Representative Sequence: NM_0058942 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368174(uc001frk.4) ENST00000484609
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD5L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD5L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CD5L (NM_005894) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CD5L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD5L |
Additional cDNA sequence: AF011429.1 AF147312.1 AK292040.1 AY358494.1 BC033586.1 U82812.1 4 DOTS entries: DT.413443 DT.101979190 DT.121383479 DT.40207025 24/52 AceView cDNA sequences (see all 52): BE384446 BX094535 AF147312 BE274956 AI022195 AA341838 AF011429 BX279835 N77007 BQ024474 BC033586 H91150 CA309054 NM_005894 AA694304 AA677254 BM091287 U82812 AY358494 BM091582 BX371695 BQ711483 BG745579 BQ711118
GeneLoc Exon Structure
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Expression
for CD5L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CD5L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGAAGACAC
About this image
See CD5L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD5L
SOURCE GeneReport for Unigene cluster: Hs.134035
UniProtKB/Swiss-Prot: CD5L_HUMAN, O43866Tissue specificity: Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoidtissues
SABiosciences Custom PCR Arrays for CD5L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD5L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD5L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD5L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD5L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD5L |
Orthologs
for CD5L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CD5L gene from 3/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
LOXL46 |
-- |
1(a) |
possible ortholog |
GL343679.1(5220-13334) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-242e21.36 |
si:dkey-242e21.3 |
6(a) |
possible ortholog |
16(43020334-43052120) |
fruit fly
(Drosophila melanogaster) |
Insecta |
lox6 |
lysyl oxidase-like |
10(a) |
possible ortholog |
3R(27284102-27285591) |
ENSEMBL Gene Tree for CD5L (if available)
TreeFam Gene Tree for CD5L (if available) |
Paralogs
for CD5L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CD5L gene
- LOXL22 CD62 CD163L12 LOXL42 LOXL32 CD1632 SSC5D2 PRSS122
- LOX2 SRCRB4D2 LOC6192072 LOXL12
6 SIMAP similar genes for CD5L using alignment to 1 protein entry: CD5L_HUMAN:CD163 CD163L1 DMBT1 PRSS12 CD6 SSC5D
CD5L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CD5L
PGOHUM00000245024
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Genomic Variants
for CD5L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CD5L (157800704 - 157868046 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD5L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD5L |
|
Disorders
/ Diseases
for CD5L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CD5L for disorders About GeneDecksing
OMIM gene information: 602592
OMIM disorders: --
17  diseases for CD5L: About MalaCardshereditary elliptocytosis elliptocytosis hereditary spherocytosis spherocytosis
wolman disease inflammatory bowel disease atopic dermatitis kawasaki disease
dermatitis hepatitis c hepatitis b choroiditis
hepatitis fibrosis cholesterol adenocarcinoma
liver fibrosis
1 disease from the University of Copenhagen DISEASES database for CD5L:Wolman disease Human Genome Epidemiology (HuGE) Navigator: CD5L (4 documents)
Export disorders for CD5L gene to outside databases
|
Publications
for CD5L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CD5L gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with CD5L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins. (PubMed id 9045627)1, 2, 3, 9 Gebe J.A.... Aruffo A. (1997)
- IgM are associated to Spalpha (CD5 antigen-like). (PubMed id 11981870)1, 2, 9 Tissot J.D.... Duchosal M.A. (2002)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide. (PubMed id 8034987)1, 2 Tissot J.-D....Schneider P. (1994)
- Modification of N-glycosylation modulates the secretio n and lipolytic function of apoptosis inhibitor of macrophage (AIM). (PubMed id 23236605)1 Mori M....Miyazaki T. (2012)
- AIMing at metabolic syndrome. -Towards the developmen t of novel therapies for metabolic diseases via apoptosis inhibitor of macropha ge (AIM).-. (PubMed id 21970839)1 Miyazaki T....Arai S. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
|
External Searches for CD5L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CD5L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CD5L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD5L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CD5L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CD5L gene:
Search GeneIP for patents involving CD5L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CD5L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD5L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD5L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD5L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD5L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD5L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD5L |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD5L |
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