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Aliases for CD5L Gene

Aliases for CD5L Gene

  • CD5 Molecule-Like 2 3
  • CD5 Antigen-Like (Scavenger Receptor Cysteine Rich Family) 2 3
  • IgM-Associated Peptide 3 4
  • Apoptosis Inhibitor 6 2 3
  • SP-ALPHA 3 4
  • CT-2 3 4
  • API6 3 4
  • CD5 Antigen-Like 3
  • Spalpha 3
  • PRO229 3
  • AIM 3

External Ids for CD5L Gene

Previous HGNC Symbols for CD5L Gene

  • API6

Previous GeneCards Identifiers for CD5L Gene

  • GC01M155669
  • GC01M153577
  • GC01M154578
  • GC01M155017
  • GC01M155011
  • GC01M154613
  • GC01M156067
  • GC01M129158

Summaries for CD5L Gene

GeneCards Summary for CD5L Gene

CD5L (CD5 Molecule-Like) is a Protein Coding gene. Diseases associated with CD5L include wolman disease. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is LOXL1.

UniProtKB/Swiss-Prot for CD5L Gene

  • May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis

Gene Wiki entry for CD5L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD5L Gene

Genomics for CD5L Gene

Regulatory Elements for CD5L Gene

Genomic Location for CD5L Gene

Start:
157,827,071 bp from pter
End:
157,898,256 bp from pter
Size:
71,186 bases
Orientation:
Minus strand

Genomic View for CD5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD5L Gene

Proteins for CD5L Gene

  • Protein details for CD5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43866-CD5L_HUMAN
    Recommended name:
    CD5 antigen-like
    Protein Accession:
    O43866
    Secondary Accessions:
    • A8K7M5
    • Q6UX63

    Protein attributes for CD5L Gene

    Size:
    347 amino acids
    Molecular mass:
    38088 Da
    Quaternary structure:
    • Associated with IgM

neXtProt entry for CD5L Gene

Proteomics data for CD5L Gene at MOPED

Post-translational modifications for CD5L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CD5L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD5L Gene

Domains for CD5L Gene

Protein Domains for CD5L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43866

UniProtKB/Swiss-Prot:

CD5L_HUMAN :
  • O43866
Domain:
  • Contains 3 SRCR domains.
genes like me logo Genes that share domains with CD5L: view

No data available for Gene Families for CD5L Gene

Function for CD5L Gene

Molecular function for CD5L Gene

GENATLAS Biochemistry: CD5 antigen-like secreted protein alpha,expressed in lymphoid tissues,potential regulator of monocyte activation,function and/or survival
UniProtKB/Swiss-Prot Function: May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis

Gene Ontology (GO) - Molecular Function for CD5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with CD5L: view

Phenotypes for CD5L Gene

MGI mutant phenotypes for CD5L:
inferred from 1 alleles
GenomeRNAi human phenotypes for CD5L:
genes like me logo Genes that share phenotypes with CD5L: view

Animal Models for CD5L Gene

MGI Knock Outs for CD5L:

Animal Model Products

CRISPR Products

miRNA for CD5L Gene

miRTarBase miRNAs that target CD5L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD5L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD5L Gene

Localization for CD5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD5L Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD5L Gene COMPARTMENTS Subcellular localization image for CD5L gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CD5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space TAS 9045627
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with CD5L: view

Pathways for CD5L Gene

SuperPathways for CD5L Gene

No Data Available

Interacting Proteins for CD5L Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357156%0d%0a9606.ENSP00000359663%0d%0a9606.ENSP00000304592%0d%0a
Selected Interacting proteins: O43866-CD5L_HUMAN ENSP00000357156 for CD5L Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for CD5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006915 apoptotic process IEA --
GO:0006968 cellular defense response TAS 9045627
genes like me logo Genes that share ontologies with CD5L: view

No data available for Pathways by source for CD5L Gene

Transcripts for CD5L Gene

mRNA/cDNA for CD5L Gene

Unigene Clusters for CD5L Gene

CD5 molecule-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD5L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD5L Gene

No ASD Table

Relevant External Links for CD5L Gene

GeneLoc Exon Structure for
CD5L
ECgene alternative splicing isoforms for
CD5L

Expression for CD5L Gene

mRNA expression in normal human tissues for CD5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD5L Gene

This gene is overexpressed in Spleen (50.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD5L Gene

SOURCE GeneReport for Unigene cluster for CD5L Gene Hs.134035

mRNA Expression by UniProt/SwissProt for CD5L Gene

O43866-CD5L_HUMAN
Tissue specificity: Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues.
genes like me logo Genes that share expressions with CD5L: view

In Situ Assay Products

Orthologs for CD5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD5L 35
  • 99.04 (n)
  • 98.56 (a)
CD5L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD5L 36
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD5L 35
  • 76.33 (n)
  • 68.05 (a)
CD5L 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd5l 35
  • 76.07 (n)
  • 70.06 (a)
Cd5l 16
Cd5l 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD5L 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD5L 36
  • 36 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd5l 35
  • 76.67 (n)
  • 69.71 (a)
lizard
(Anolis carolinensis)
Reptilia CD5L 36
  • 10 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-161n3.3 36
  • 8 (a)
ManyToMany
Species with no ortholog for CD5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD5L Gene

ENSEMBL:
Gene Tree for CD5L (if available)
TreeFam:
Gene Tree for CD5L (if available)

Paralogs for CD5L Gene

Paralogs for CD5L Gene

Selected SIMAP similar genes for CD5L Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CD5L Gene

genes like me logo Genes that share paralogs with CD5L: view

Variants for CD5L Gene

Sequence variations from dbSNP and Humsavar for CD5L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1048086 -- 157,831,788(-) CCCCC(A/T)TTGCT utr-variant-3-prime, intron-variant
rs1804957 -- 157,836,097(-) GTGGA(G/T)GTGGA reference, missense
rs1804958 -- 157,831,808(-) TTACT(C/T)TCAGG utr-variant-3-prime, intron-variant
rs2260040 -- 157,841,602(+) TTGGC(A/G)GGGAG intron-variant
rs2261295 -- 157,833,189(-) CAGGT(A/G)AGTCC intron-variant

Relevant External Links for CD5L Gene

HapMap Linkage Disequilibrium report
CD5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD5L Gene

Disorders for CD5L Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CD5L Gene including...

Search for CD5L Gene in MalaCards »

(1) University of Copenhagen DISEASES for CD5L Gene

Relevant External Links for CD5L

Genetic Association Database (GAD)
CD5L
Human Genome Epidemiology (HuGE) Navigator
CD5L
genes like me logo Genes that share disorders with CD5L: view

No data available for UniProtKB/Swiss-Prot for CD5L Gene

Publications for CD5L Gene

  1. Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins. (PMID: 9045627) Gebe J.A. … Aruffo A. (J. Biol. Chem. 1997) 2 3 4 23
  2. IgM are associated to Spalpha (CD5 antigen-like). (PMID: 11981870) Tissot J.D. … Duchosal M.A. (Electrophoresis 2002) 3 4 23
  3. Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide. (PMID: 8034987) Tissot J.-D. … Schneider P. (J. Immunol. Methods 1994) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for CD5L Gene

Sources for CD5L Gene

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