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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD59 Gene

protein-coding GIFtS: 66
GCID: GC11M033721

CD59 molecule, complement regulatory protein

(Previous names: CD59 antigen p18-20 (antigen identified by monoclonal antibodies...)
(Previous symbols: MIC11, MIN1, MSK21, MIN2, MIN3)

Explore 102 diseases affiliated with
CD59 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD59 Molecule, Complement Regulatory Protein¹ ²		MAC-IP² ³
MIC11¹ ² ³ ⁵		MACIF² ³
MIN1¹ ² ³		MIRL² ³
MIN2¹ ² ³		MEM43 Antigen² ³
MIN3¹ ² ³		CD59 Antigen, Complement Regulatory Protein¹
MSK21¹ ² ³		1F5²
16.3A5¹ ²		MEM43²
EJ16¹ ²		CD59 Glycoprotein²
EJ30¹ ²		Human Leukocyte Antigen MIC11²
EL32¹ ²		Ly-6-Like Protein²
G344¹ ²		Lymphocytic Antigen CD59/MEM43²
CD59 Antigen P18-20 (Antigen Identified By Monoclonal Antibodies 16.3A5, EJ16, EJ30, EL32 And G344)¹ ²		Membrane Attack Complex (MAC) Inhibition Factor²
P18-20¹		Protectin³
Membrane Attack Complex Inhibition Factor² ³		Surface Anitgen Recognized By Monoclonal Antibody 16.3A5²
Membrane Inhibitor Of Reactive Lysis² ³		T Cell-Activating Protein²
1F5 Antigen² ³		Protectin³
20 KDa Homologous Restriction Factor² ³		CD59 Antigen³
HRF-20² ³		MAC-Inhibitory Protein³
HRF20² ³

External Ids:	HGNC: 1689¹	Entrez Gene: 966²	Ensembl: ENSG00000085063⁷	OMIM: 107271⁵	UniProtKB: P13987³

Export aliases for CD59 gene to outside databases

Previous GC identifers: GC11M035262 GC11M034408 GC11M033758 GC11M033694 GC11M033688 GC11M033681 GC11M033421

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD59:

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in

lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby

it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple

copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in

signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease

resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced

transcript variants, which encode the same protein, have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD59_HUMAN, P13987

Function: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9

complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete

formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for

T-cell activation complexed to a protein tyrosine kinase

Function: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced

ability to inhibit MAC assembly on cell membranes

Gene Wiki entry for CD59

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD59 gene promoter:
GR
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD59 promoter sequence

Search SABiosciences Chromatin IP Primers for CD59

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD59

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13

CD59 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD59 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M033721: view genomic region (about GC identifiers)

Start:	33,719,807 bp from pter	End:	33,758,025 bp from pter
Size:	38,219 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD59_HUMAN, P13987 (See protein sequence)

Recommended Name: CD59 glycoprotein precursor

Size: 128 amino acids; 14177 Da

Subunit: Interacts with T-cell surface antigen CD2

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Soluble form found in a number of tissues

6/9 PDB 3D structures from and Proteopedia for CD59 (see all 9):

1CDQ (3D)

1CDR (3D)

1CDS (3D)

1ERG (3D)

1ERH (3D)

2J8B (3D)

Explore the universe of human proteins at neXtProt for CD59: NX_P13987

Post-translational modifications:

N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and

without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes

(22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated

forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The

GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different

GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine

Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants¹

Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59

lacks MAC-inhibitory function and confers to vascular complications of diabetes¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P13987

CD59 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (8 alternative transcripts):

NP_000602.1 NP_001120695.1 NP_001120697.1 NP_001120698.1 NP_001120699.1 NP_976074.1 NP_976075.1 NP_976076.1

ENSEMBL proteins:

ENSP00000432362 ENSP00000437122 ENSP00000435179 ENSP00000436497 ENSP00000379191

ENSP00000436737 ENSP00000340210 ENSP00000404822 ENSP00000403511 ENSP00000402425

ENSP00000410182 ENSP00000432942 ENSP00000434617

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD59
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CD59 OriGene Protein Over-expression Lysate (see all 11): CD59 OriGene Custom Protein Services for CD59
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	Novus Biologicals CD59 Protein Novus Biologicals CD59 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD59

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	IEA	--
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	NAS	1381503
GO:0009986	cell surface	IDA	15907827

CD59 for ontologies About GeneDecksing

CD59 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD59
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	OriGene Antibodies (see all 2): CD59 OriGene Custom Antibody Services for CD59
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	Novus Biologicals CD59 Antibodies
	Abcam antibodies for CD59
	Uscn Antibodies for CD59
	ThermoFisher Antibody for CD59

Assay Products for CD59:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD59

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD59 for domains About GeneDecksing

4 InterPro domains/families:

IPR027101 CD59_glyco

IPR018363 CD59_antigen_CS

IPR016054 LY6_UPA_recep-like

IPR001526 LY6_UPAR

Graphical View of Domain Structure for InterPro Entry P13987

ProtoNet protein and cluster: P13987

1 Blocks protein family: IPB001526 CD59 antigen

UniProtKB/Swiss-Prot: CD59_HUMAN, P13987

Similarity: Contains 1 UPAR/Ly6 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD59_HUMAN, P13987

Function: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9

complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete

formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for

T-cell activation complexed to a protein tyrosine kinase

Function: The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced

ability to inhibit MAC assembly on cell membranes

Genatlas biochemistry entry for CD59:

cell differentiation antigen CD59 (gp18),18-20kDa,glycosyl-phosphatidylinositol (GPI) linked membrane

glycoprotein,identified by monoclonal antibodies YTH53.1,MEM-43 (protectin)

miRNA Products:		miRTarBase miRNAs that target CD59: hsa-mir-124 (MIRT002624)

		OriGene 3'-UTR Clone (see all 8): CD59 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD59
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CD59 (see all 22):
		hsa-miR-3678-3p hsa-miR-320a hsa-miR-26a-2* hsa-miR-888* hsa-miR-4314 hsa-miR-149 hsa-miR-3116 hsa-miR-3662

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD59

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		GenScript: all cDNA clones in your preferred vector (see all 8): CD59 (NM_001127223)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD59
		Search LifeMap BioReagents cell lines for CD59

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD59

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001848	complement binding	IEA	--
GO:0005515	protein binding	IPI	--

CD59 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CD59:

Decreased POU5F1-GFP protein e

Decreased viability of wild-ty

Animal Models:
Mouse knock-outs for CD59: Cd59a/Cd59b^Cd59a/tm1Jha Cd59b^tm1Jha
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd59b):

cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	mortality/aging
renal/urinary system	reproductive system

CD59 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_Alternative complement pathway

	Immune response Alternative complement pathway	1.00			Immune response_Lectin induced complement pathway	0.56
	Immune response_Alternative complement pathway	1.00			Immune response Lectin Induced complement pathway	0.56

Immune response_Classical complement pathway

Immune response_Classical complement pathway

1.00

Immune response Classic complement pathway

0.98

Arf6 trafficking events

Arf6 trafficking events

1.00

Hematopoietic cell lineage

Hematopoietic cell lineage

1.00

Complement and coagulation cascades

Complement and coagulation cascades

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CD59

	Immune response Alternative complement pathway
	Immune response Classic complement pathway
	Immune response Lectin Induced complement pathway

3 GeneGo (Thomson Reuters) Pathways for CD59

	Immune response Alternative complement pathway
	Immune response Classical complement pathway
	Immune response Lectin induced complement pathway

1 BioSystems Pathway for CD59

Arf6 trafficking events

2 Kegg Pathways (Kegg details for CD59):

	Complement and coagulation cascades
	Hematopoietic cell lineage

CD59 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD59

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/20 Interacting proteins for CD59 (P13987^{1, 2, 3} ENSP00000340210⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-61560 I2D: score=2 STRING: ENSP00000339007
SMAD4	Q13485²^,³, ENSP00000341551⁴	MINT-61968 I2D: score=3 STRING: ENSP00000341551
NCR3	O14931³, ENSP00000342156⁴	I2D: score=3 STRING: ENSP00000342156
CD2	P06729³, ENSP00000358490⁴	I2D: score=2 STRING: ENSP00000358490
CFTR	P13569³, ENSP00000003084⁴	I2D: score=1 STRING: ENSP00000003084

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001971	negative regulation of activation of membrane attack complex	IEA	--
GO:0007166	cell surface receptor signaling pathway	TAS	7691713
GO:0007596	blood coagulation	TAS	1381503
GO:0042102	positive regulation of T cell proliferation	IEA	--
GO:0043066	negative regulation of apoptotic process	IEA	--

CD59 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD59 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD59
10/34 Novoseek chemical compound relationships for CD59 gene (see all 34) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hmcp	69	2	16324389 (1), 15693845 (1)
docosahexaenoic acid	64	23	18489792 (2), 18922179 (1), 19221636 (1), 19736623 (1) (see all 14)
eicosapentaenoic acid	58.7	17	18489792 (2), 18922179 (1), 19221636 (1), 19736623 (1) (see all 9)
anaphylatoxin	53.2	1	9121154 (1)
galalpha(1,3)gal	50.1	3	10910270 (2)
rituximab	43.9	21	11520782 (4), 11394505 (3), 11719378 (2), 16289746 (2) (see all 9)
glycolipid	31.2	4	7527603 (1), 1372260 (1), 8804039 (1), 1280224 (1)
phosphatidylinositol	29.7	34	1379443 (4), 12950982 (2), 2242615 (2), 7527236 (1) (see all 12)
lipid	29.2	45	7519171 (3), 1698710 (2), 16927933 (2), 16303609 (2) (see all 28)
ganglioside	20.1	6	9003426 (1), 8569195 (1), 10064071 (1), 7688394 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about CD59

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD59 gene (8 alternative transcripts):

NM_000611.5 NM_001127223.1 NM_001127225.1 NM_001127226.1 NM_001127227.1 NM_203329.2 NM_203330.2 NM_203331.2

Unigene Clusters for CD59:

CD59 molecule, complement regulatory protein

Hs.278573 [show with all ESTs], Hs.709466 [show with all ESTs]

Unigene Representative Sequences: NM_001127223, BU856135

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534312 ENST00000527926 ENST00000525763 ENST00000533181 ENST00000395850(uc009yjx.3 uc009yjy.3 uc009yjz.3 uc001mut.4 uc009yka.3 uc001muu.4 uc001muv.4)

ENST00000533403 ENST00000351554 ENST00000528987 ENST00000415002(uc001mus.4)

ENST00000445143 ENST00000426650 ENST00000437761 ENST00000527577 ENST00000528700

miRNA Products:		OriGene 3'-UTR Clone (see all 8): CD59 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD59
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CD59 (see all 22):
		hsa-miR-3678-3p hsa-miR-320a hsa-miR-26a-2* hsa-miR-888* hsa-miR-4314 hsa-miR-149 hsa-miR-3116 hsa-miR-3662

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB231759.1 AB231760.1 BT007104.1 CR407661.1 CR541722.1 M27909.1

24/56 DOTS entries (see all 56):

DT.100883726 DT.95110568 DT.95179543 DT.100883738 DT.100783392 DT.95226254 DT.40272730 DT.95179586

DT.100883723 DT.100883703 DT.100883737 DT.455383 DT.120725036 DT.120725237 DT.91887599 DT.95179583

DT.95179510 DT.92470437 DT.100883742 DT.100783395 DT.95179588 DT.95179506 DT.100883739 DT.100888833

24/1489 AceView cDNA sequences (see all 1489):

N41637 CR620800 H96384 BM704103 CR612934 BU621210 CB122979 CA310446

BF725725 BQ776013 AL540912 AA564405 BM992665 BU150707 CD609149 CD675013

CF529941 BM789981 AL544203 AL546429 CA432503 BI118113 CR608941 W03077

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CD59 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	·	8f	·	8g	·	8h
SP1:							-				-		-								-
SP2:							-				-		-								-
SP3:													-								-
SP4:																					-
SP5:							-		-		-		-								-

ECgene alternative splicing isoforms for CD59

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD59 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACTGGCAG

About this image

CD59 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Endometrial regenerative cell (Adult Stem / Progenitor Cell)

Reproductive System

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CD59 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD59

SOURCE GeneReport for Unigene clusters: Hs.278573 Hs.709466

SABiosciences Expression via Pathway-Focused PCR Array including CD59:

Angiogenic Growth Factors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD59 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD59

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD59 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd59b^{1 , 5}	CD59b antigen^{1, 5}	60.12(n)¹ 48.21(a)¹		2 (54.51 cM)⁵ 333883¹ NM_181858.1¹ NP_862906.1¹ 104069849⁵
chicken (Gallus gallus)	Aves	CD59⁶	Uncharacterized protein	33(a)	1 ↔ 1	5(19767161-19769738)
zebrafish (Danio rerio)	Actinopterygii	BX957297.2⁶ BX088562.1⁶	--	29(a) 25(a)	many → 1 many → 1	7(40087926-40089040) 25(7943071-7946677)

ENSEMBL Gene Tree for CD59 (if available)
TreeFam Gene Tree for CD59 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188677921^1,2		--	33724135(+)	`CAATCA/GCCCAT`	9	--	ds500¹ us2k¹		0	--	--	--	--
rs61589887^1,2	F,	--	33724198(+)	`TTCTGT/CAAGAA`	9	--	ds500¹ us2k¹		1		WA	118
rs77762316^1,2	C,F,	--	33724613(+)	`ATTTTT/GTATGT`	8	--	ut3¹		1		EA	120
rs191183213^1,2		--	33724744(+)	`TTAAAC/TAAGAA`	8	--	ut3¹		0	--	--	--	--
rs704697^1,2	C,F,A,H,	--	33724780(+)	`ACAAGC/TATGCA`	8	--	ut3¹ ese³		27		NS EA WA NA CSA	2771
rs183772812^1,2		--	33724789(+)	`CAAGAA/GAACTC`	8	--	ut3¹		0	--	--	--	--
rs78000603^1,2		--	33724881(+)	`AAAACC/ACTACG`	8	--	ut3¹		1		NA	120
rs79094033^1,2	C,F,	--	33724885(+)	`CCCTAC/TGGTTG`	8	--	ut3¹		1		WA	118
rs190341475^1,2		--	33724888(+)	`TACGGC/TTGTTT`	8	--	ut3¹		0	--	--	--	--
rs1047581^1,2	C,F,O,A,H,	--	33724992(-)	`GTGACA/GTAGTG`	8	--	ut3¹		28		EA NA NS WA	2980

HapMap Linkage Disequilibrium report for CD59 (33719807 - 33758025 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD59: --
Human Gene Mutation Database (HGMD): CD59

Locus Specific Mutation Databases (LSDB): CD59

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD59

DNA2.0 Custom Variant and Variant Library Synthesis for CD59

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD59 for disorders           About GeneDecksing

OMIM gene information: 107271
OMIM disorders: 612300
UniProtKB/Swiss-Prot: CD59_HUMAN, P13987

Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:612300]

20/102 diseases for CD59 (see all 102): About MalaCards

hemolytic anemia cerebral infarction anemia thrombosis

paroxysmal nocturnal hemoglobinuria cerebritis autoimmune hemolytic anemia age related macular degeneration

plasmodium falciparum malaria hemoglobinuria abdominal aortic aneurysm duchenne muscular dystrophy

non-hodgkin lymphoma aortic aneurysm infectious mononucleosis macular degeneration

squamous cell carcinoma membranous glomerulonephritis lupus erythematosus muscular dystrophy

3 diseases from the University of Copenhagen DISEASES database for CD59:

Anemia Proteinuria Bone marrow disease

10/90 Novoseek disease relationships for CD59 gene (see all 90) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
paroxysmal hemoglobinuria nocturnal	91.5	35	15053802 (2), 1382994 (2), 19154662 (2), 7536494 (2) (see all 25)
hemolysis	61.9	24	11881969 (2), 7519172 (1), 9145329 (1), 9595015 (1) (see all 15)
hemoglobinuria	60	2	9844822 (1), 10539884 (1)
anemia aplastic	57	2	7544152 (1), 11930678 (1)
somatic mutations	42	2	19399743 (1), 7522635 (1)
anemia hemolytic	39.8	2	11986227 (1), 11930678 (1)
tumor escape	39.6	2	16507249 (2)
inflammation	39	33	16927933 (3), 17337246 (2), 16489052 (2), 19594757 (2) (see all 24)
autoimmune hemolytic anemia	38.4	3	11930678 (1), 18954403 (1), 17289551 (1)
cytopenia	29.4	1	17289551 (1)

Genatlas disease: CD59

hemoglobinuria,paroxysmal,nocturnal,rare inherited form associated or not with aplastic anemia

Human Genome Epidemiology (HuGE) Navigator: CD59 (4 documents)

Export disorders for CD59 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD59 gene, integrated from 9 sources (see all 526):
(articles sorted by number of sources associating them with CD59)

Utopia: connect your pdf to the dynamic
world of online information

Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene. (PubMed id 1382994)^{1, 2, 9} Motoyama N.... Okada H. (1992)
Structural composition and functional characterization of soluble CD59: heterogeneity of the oligosaccharide and glycophosphoinositol (GPI) anchor revealed by laser-desorption mass spectrometric analysis. (PubMed id 8670172)^{1, 2, 9} Meri S....Baumann M. (1996)
Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. (PubMed id 1381503)^{1, 2, 9} Petranka J.G.... Rosse W.F. (1992)
The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the ''b'' domain of C9. (PubMed id 1377690)^{1, 2, 9} Ninomiya H. and Sims P.J. (1992)
Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol- anchored proteins released upon phospholipase D treatment. (PubMed id 16602701)^{1, 2} Elortza F.... Jensen O.N. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins. (PubMed id 14517339)^{1, 2} Elortza F....Jensen O.N. (2003)
Molecular basis for a link between complement and the vascular complications of diabetes. (PubMed id 10805801)^{1, 2} Acosta J.... Halperin J. (2000)
Mutational analysis of the active site and antibody epitopes of the complement-inhibitory glycoprotein, CD59. (PubMed id 9053451)^{1, 2} Bodian D.L.... Rushmere N.K. (1997)
Mapping the regions of the complement inhibitor CD59 responsible for its species selective activity. (PubMed id 9235986)^{1, 2} Yu J.... Tomlinson S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 966	HGNC: 1689	AceView: CD59	Ensembl:ENSG00000085063	euGenes: HUgn966
ECgene: CD59	Kegg: 966	H-InvDB: CD59

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD59	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD59	Genetics and Cytogenetics in Oncology and Haematology
CD59base	http://bioinf.uta.fi/CD59base/

Intellectual Property for CD59 gene
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Patent Information for CD59 gene:
Search GeneIP for patents involving CD59

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CD59 Gene

CD59 molecule, complement regulatory protein

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CD59 (Gene Symbol)
CD59 Molecule, Complement Regulatory Protein
MIC11
MIN1
MIN2
MIN3
MSK21
16.3A5
EJ16
EJ30
EL32
G344
CD59 Antigen P18-20 (Antigen Identified By Monoclonal Antibodies 16.3A5, EJ16, EJ30, EL32 And G344)
P18-20
Membrane Attack Complex Inhibition Factor
Membrane Inhibitor Of Reactive Lysis
1F5 Antigen
20 KDa Homologous Restriction Factor
HRF-20
HRF20
MAC-IP
MACIF
MIRL
MEM43 Antigen
CD59 Antigen, Complement Regulatory Protein
1F5
MEM43
CD59 Glycoprotein
Human Leukocyte Antigen MIC11
Ly-6-Like Protein
Lymphocytic Antigen CD59/MEM43
Membrane Attack Complex (MAC) Inhibition Factor
Protectin
Surface Anitgen Recognized By Monoclonal Antibody 16.3A5
T Cell-Activating Protein
Protectin
CD59 Antigen
MAC-Inhibitory Protein

Autoimmune hemolytic anemia
Anemia Hemolytic
Waldenstrom Macroglobulinemia
Nephropathy Membranous
Colitis Ulcerative
LUNG CARCINOMA
Lymphoma Follicular
Ischemia
Atherosclerosis
Nasal Epithelium
Breast Cancer
Metaplasia
Adenocarcinoma
cell damage
Cancer
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Colorectal Carcinoma
somatic mutations
Lymphoma
Ovarian Cancer
Colorectal Cancer
Multiple Sclerosis
Inflammation
Burkitt Lymphoma
immunodeficiency
Psoriasis
Hyperglycemia
Cervical Cancer
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prostate cancer
Tumors
Metastasis
Lymphoblastic Leukemia Acute
Necrosis
Hemoglobinuria
Malignant Glioma
Senile Plaques
Paroxysmal Hemoglobinuria Nocturnal
Gastric Cancer
Melanoma
BREAST CARCINOMA
Autoimmune Diseases
Colon Cancer
promyelocytic leukemia
Leukemia Lymphocytic Chronic
Glioma
atherosclerotic plaque
Demyelination
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INFARCT
Osteoarthritis
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uveal melanoma
OVARIAN CARCINOMA
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autoimmune thyroid disease
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CD59 Gene

CD59 molecule, complement regulatory protein

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