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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD58 Gene

protein-coding   GIFtS: 66
GCID: GC01M117059

CD58 Molecule

(Previous names: CD58 antigen, (lymphocyte function-associated antigen 3))
(Previous symbol: LFA3)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CD58 Molecule1 2     ag32
LFA31 2 3 5     Lymphocyte Function-Associated Antigen 32
CD58 Antigen, (Lymphocyte Function-Associated Antigen 3)1 2     Ag33
Surface Glycoprotein LFA-32 3     CD58 Antigen3
LFA-32     

External Ids:    HGNC: 16881   Entrez Gene: 9652   Ensembl: ENSG000001168157   OMIM: 1534205   UniProtKB: P192563   
ORGUL members:         
NONCODE14:n407201 n334388      

Export aliases for CD58 gene to outside databases

Previous GC identifers: GC01M117560 GC01M115939 GC01M116204 GC01M116403 GC01M116758 GC01M116858 GC01M114916


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD58 Gene:
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte
CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma
membrane. Alternatively spliced transcript variants have been described. (provided by RefSeq, Jan 2009)

GeneCards Summary for CD58 Gene: 
CD58 (CD58 molecule) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CD58 include oral lichen planus, and vaccinia, and among its related super-pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: LFA3_HUMAN, P19256
Function: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte
interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with
target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the
LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD58 gene promoter:
         ER-alpha   CREB   PPAR-gamma1   IRF-2   Ik-2   deltaCREB   Lmo2   PPAR-gamma2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD58 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD58

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD58


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13

CD58 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD58 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M117059:  view genomic region     (about GC identifiers)

Start:
117,057,156 bp from pter      End:
117,113,715 bp from pter
Size:
56,560 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CD58

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LFA3_HUMAN, P19256 (See protein sequence)
Recommended Name: Lymphocyte function-associated antigen 3 precursor  
Size: 250 amino acids; 28147 Da
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor
3 PDB 3D structures from and Proteopedia for CD58:
1CCZ (3D)        1CI5 (3D)        1QA9 (3D)    
Secondary accessions: A8K7G5 Q5U053 Q6IB65 Q96KI9
Alternative splicing: 3 isoforms:  P19256-1   P19256-2   P19256-3   (GPI-anchor amidated asparagine on Asn-235. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CD58: NX_P19256

Explore proteomics data for CD58 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P19256

  • CD58 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD58 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138294.1  NP_001770.1  

    ENSEMBL proteins: 
     ENSP00000358501   ENSP00000432773   ENSP00000409080   ENSP00000433648   ENSP00000358499  
    Reactome Protein details: P19256
    Human Recombinant Protein Products for CD58: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD58 (CD58/LFA-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CD58
    GenScript Custom Purified and Recombinant Proteins Services for CD58
    Novus Biologicals CD58 Proteins
    Novus Biologicals CD58 Lysate
    Sino Biological Recombinant Protein for CD58
    Sino Biological Cell Lysate for CD58 
    ProSpec Recombinant Protein for CD58
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS7544493
    GO:0031225anchored to membrane IEA--

    CD58 for ontologies           About GeneDecksing



    CD58 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD58
    R&D Systems Antibodies for CD58 (CD58/LFA-3)
    OriGene Antibodies for CD58
    OriGene Custom Antibody Services for CD58
    GenScript Custom Superior Antibodies Services for CD58
    Novus Biologicals CD58 Antibodies
    Abcam antibodies for CD58
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CD58
    LSBio Antibodies in human, mouse, rat for CD58 

    Assay Products for CD58: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD58
    R&D Systems Proteome Profiler Antibody Arrays for CD58 (CD58/LFA-3)
    GenScript Custom Assay Services for CD58
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    3 InterPro protein domains:
     IPR015714 Lymphocyte_func-assoc_Ag_3
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P19256

    ProtoNet protein and cluster: P19256

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: LFA3_HUMAN, P19256
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    CD58 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LFA3_HUMAN, P19256
    Function: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte
    interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with
    target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the
    LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells

         Genatlas biochemistry entry for CD58:
    cell differentiation antigen CD58 (LFA-3),40-65kDa,identified by monoclonal antibodies G26,BRIC5,TS2/9,Ig
    superfamily,T cell restricted CD2 ligand

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI7544493
         
    CD58 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CD58:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD58 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD58

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD58 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD58 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD58
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD58:
    hsa-miR-452* hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidCD58 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD58
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD58

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD58
    Sirion Biotech Customized adenovirus for overexpression of CD58

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD58 (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD58 (NM_001144822)
    Sino Biological Human cDNA Clone for CD58
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD58
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD58
    Sirion Biotech Customized lentivirus for stable overexpression of CD58 
                         Customized lentivirus expression plasmids for stable overexpression of CD58 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CD58
    Search LifeMap BioReagents cell lines for CD58
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD58


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD58 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Platelet activation, signaling and aggregation
    Hemostasis0.43
    2Epstein-Barr virus infection
    Epstein-Barr virus infection
    3Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2        Reactome Pathways for CD58
        Hemostasis
    Cell surface interactions at the vascular wall


    2         Kegg Pathways  (Kegg details for CD58):
        Cell adhesion molecules (CAMs)
    Epstein-Barr virus infection


    CD58 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD58

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for CD58 (P192562, 3 ENSP000003585014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202211 I2D: score=1 STRING: ENSP00000250416
    CD2P067293, ENSP000003584904I2D: score=4 STRING: ENSP00000358490
    DNAJA1P316893, ENSP000003691274I2D: score=4 STRING: ENSP00000369127
    HERPUD1Q150113I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS10380930
    GO:0007596blood coagulation TAS--
    GO:0016337cell-cell adhesion NAS7544493
    GO:0050900leukocyte migration TAS--

    CD58 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD58 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD58 (LFA3)

    10/16 Novoseek inferred chemical compound relationships for CD58 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alefacept 70.4 8 17403057 (2), 17970892 (1), 11881524 (1), 12384938 (1) (see all 6)
    metronidazole 40.4 12 19009294 (2), 12384537 (1), 16081691 (1), 18197807 (1) (see all 9)
    slex 30.4 2 8838015 (1), 7576475 (1)
    rantes 9.41 1 15730495 (1)
    lipid 1.98 1 11884440 (1)
    lysine 0 2 15347975 (1)
    heparan sulfate 0 3 9891023 (1)
    phosphatidylinositol 0 4 1698448 (1), 1715960 (1)
    ganciclovir 0 2 8900310 (1)
    cisplatin 0 3 8816858 (2)

    Search CenterWatch for drugs/clinical trials and news about CD58 / LFA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD58 gene (2 alternative transcripts): 
    NM_001144822.1  NM_001779.2  

    Unigene Cluster for CD58:

    CD58 molecule
    Hs.34341  [show with all ESTs]
    Unigene Representative Sequence: NM_001144822
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369489(uc001egm.3 uc001egn.3) ENST00000464088(uc001ego.1)
    ENST00000457047(uc010owy.2) ENST00000526981 ENST00000369487(uc001egp.4)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD58
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD58:
    hsa-miR-452* hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidCD58 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD58
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD58
    Clone
    Products:
         
    OriGene clones in human, mouse for CD58 (see all 10)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD58 (NM_001144822)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD58
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD58
    Sirion Biotech Customized lentivirus for stable overexpression of CD58 
                         Customized lentivirus expression plasmids for stable overexpression of CD58 
    Primer
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    OriGene qPCR primer pairs and template standards for CD58
    OriGene qSTAR qPCR primer pairs in human, mouse for CD58
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD58
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD58
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD58

    Additional mRNA sequence: 

    AK291980.1 BC005930.1 BT019816.1 BT019817.1 CR456939.1 D28586.1 EF491785.1 NR_026665.1 
    S79616.1 X06296.1 Y00636.1 

    6 DOTS entries:

    DT.446694  DT.95269817  DT.92060021  DT.214662  DT.99999279  DT.205322 

    24/109 AceView cDNA sequences (see all 109):

    CB145710 AK125710 BQ084474 BQ083515 D28586 CA312196 CA426675 NM_001779 
    AA761313 BI791505 BQ006845 BM991806 AI289137 AA441868 CA312671 CR456939 
    Y00636 BM822426 BQ229508 CA865722 AW008902 CA865476 CA306215 BM979711 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD58    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:                                            -                     
    SP2:                                            -     -               
    SP3:                                                                  
    SP4:                                -           -     -               


    ECgene alternative splicing isoforms for CD58

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD58 expression in normal human tissues (normalized intensities)      CD58 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGTGCTG
    CD58 Expression
    About this image


    CD58 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Adipose-derived stromal cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             monocytes   
     
     Mesenchymal Stem Cells
             Adipose-derived stromal cells
     
     Testis (Reproductive System)

    See CD58 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD58

    SOURCE GeneReport for Unigene cluster: Hs.34341
        SABiosciences Custom PCR Arrays for CD58
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD58
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD58

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD58 gene from 2/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CD586
    CD58 molecule
    49(a)
    1 ↔ 1
    17(53973029-53995788)
    zebrafish
    (Danio rerio)
    Actinopterygii CD58 (2 of 2)6
    CD58 (1 of 2)6
    CD58 molecule
    23(a)
    12(a)
    many → 1
    many → 1
    9(40692-43947)
    9(14046-25392)


    ENSEMBL Gene Tree for CD58 (if available)
    TreeFam Gene Tree for CD58 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/919 SNPs in CD58 are shown (see all 919)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108021891,2
    C,F,A,H--117056730(+) GCTGCT/CAGAGG 2 -- ds500123Minor allele frequency- C:0.34NS EA NA WA CSA 2352
    rs1920563221,2
    --117056746(+) GGCACC/TGTCCA 2 -- ds50010--------
    rs1135552241,2
    C,F--117056747(+) GCACCG/ATCCAC 2 -- ds50012Minor allele frequency- A:0.06CSA WA 120
    rs1137825951,2
    F--117056985(+) GCCTCG/ATACTG 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1834250741,2
    --117057046(+) ATGACA/CCTACA 2 -- ds50010--------
    rs1871141111,2
    --117057074(+) TAAAGA/CAAGGG 2 -- ds50010--------
    rs790508361,2
    C--117057356(+) TGTAAC/TACTCA 2 -- ut31 nc-transcript-variant0--------
    rs1997175201,2
    --117057410(+) TATGCC/TGTTGT 2 -- ut31 nc-transcript-variant0--------
    rs1172848651,2
    F--117057615(+) GCTCTT/CGGGAT 2 -- int11Minor allele frequency- C:0.02EA 120
    rs1900453881,2
    --117057667(+) GCACTC/TAATAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for CD58 (117057156 - 117113715 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CD58:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663968CNV Deletion23128226
    esv2512482CNV Deletion19546169
    esv2716607CNV Deletion23290073
    esv2209199CNV Deletion18987734
    esv1003883CNV Deletion20482838
    esv3433CNV Deletion18987735
    esv267986CNV Insertion20981092
    esv7455CNV Loss19470904


    Human Gene Mutation Database (HGMD): CD58
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153420    OMIM disorders: --

    20/52 diseases for CD58 (see all 52):    About MalaCards
    oral lichen planus    vaccinia    primary effusion lymphoma    lichen planus
    hemoglobinuria    paroxysmal nocturnal hemoglobinuria    glanders    cholera
    hepatitis b    hepatitis b virus infection    squamous cell carcinoma of the head and neck    psoriatic arthritis
    human t-cell leukemia virus type 1    viral hepatitis    protein s deficiency    acute leukemia
    liver disease    myeloma    multiple sclerosis    tetanus

    5 diseases from the University of Copenhagen DISEASES database for CD58:
    Vaccinia     Leukemia     Psoriasis     Tetanus
    Lymphoma

    CD58 for disorders           About GeneDecksing

    10/42 Novoseek inferred disease relationships for CD58 gene (see all 42)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fowlpox 78.5 9 12384537 (1), 15010371 (1), 16451103 (1), 18483372 (1) (see all 8)
    necrosis 48 14 1906507 (1), 7523228 (1), 1718801 (1), 7686816 (1) (see all 12)
    tumors 42.6 53 8592403 (3), 8816858 (2), 10094205 (2), 7690630 (2) (see all 30)
    paroxysmal hemoglobinuria nocturnal 42 5 1688724 (2), 9516159 (1)
    lichen planus oral 33.9 6 8705826 (2), 10564548 (1), 9708688 (1)
    leukemia lymphocytic chronic 32.4 1 19009294 (1)
    myeloma 29.4 10 1382543 (2), 8797890 (2), 7861616 (1)
    melanoma 27.6 22 7685328 (4), 7686816 (4), 9651826 (2), 1689276 (2) (see all 10)
    psoriasis 27.6 3 1654990 (1), 17403057 (1)
    arthritis psoriatic 26.6 1 12384938 (1)

    Genetic Association Database (GAD): CD58
    Human Genome Epidemiology (HuGE) Navigator: CD58 (20 documents)

    Export disorders for CD58 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD58 gene, integrated from 9 sources (see all 379):
    (articles sorted by number of sources associating them with CD58)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene. (PubMed id 9510189)1, 2, 3, 9 Wallich R.... Meuer S. (1998)
    2. The role of the CD58 locus in multiple sclerosis. (PubMed id 19237575)1, 4, 9 De Jager P.L....Hafler D.A. (2009)
    3. Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution. (PubMed id 10200255)1, 2, 9 Ikemizu S.... Davis S.J. (1999)
    4. Genome-wide meta-analysis identifies novel multiple sc lerosis susceptibility loci. (PubMed id 22190364)1, 4 Patsopoulos N.A....de Bakker P.I. (2011)
    5. Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis. (PubMed id 20806065)1, 4 Ryckman K.K....Hennig B.J. (2010)
    6. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. (PubMed id 19525955)1, 4 (2009)
    7. Integration of genetic risk factors into a clinical a lgorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PubMed id 19879194)1, 4 De Jager P.L.... E.W. (2009)
    8. Risk alleles for multiple sclerosis in multiplex fami lies. (PubMed id 19506219)1, 4 D'Netto M.J....Ebers G.C. (2009)
    9. Genetic variants at CD28, PRDM1 and CD2/CD58 are asso ciated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (2009)
    10. Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. (PubMed id 19110536)1, 4 Fung E.Y....Todd J.A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 965 HGNC: 1688 AceView: CD58 Ensembl:ENSG00000116815 euGenes: HUgn965
    ECgene: CD58 Kegg: 965 H-InvDB: CD58

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD58 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD58 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD58 gene:
    Search GeneIP for patents involving CD58

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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