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Aliases for CD58 Gene

Aliases for CD58 Gene

  • CD58 Molecule 2 3
  • LFA3 3 4 6
  • CD58 Antigen, (Lymphocyte Function-Associated Antigen 3) 2 3
  • Surface Glycoprotein LFA-3 3 4
  • AG3 3 4
  • Lymphocyte Function-Associated Antigen 3 3
  • CD58 Antigen 4
  • LFA-3 3

External Ids for CD58 Gene

Previous HGNC Symbols for CD58 Gene

  • LFA3

Previous GeneCards Identifiers for CD58 Gene

  • GC01M117560
  • GC01M115939
  • GC01M116204
  • GC01M116403
  • GC01M116758
  • GC01M116858
  • GC01M117059
  • GC01M114916

Summaries for CD58 Gene

Entrez Gene Summary for CD58 Gene

  • This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

GeneCards Summary for CD58 Gene

CD58 (CD58 Molecule) is a Protein Coding gene. Diseases associated with CD58 include hemorrhagic fever with renal syndrome and oral lichen planus. Among its related pathways are Hemostasis and Epstein-Barr virus infection.

UniProtKB/Swiss-Prot for CD58 Gene

  • Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD58 Gene

Genomics for CD58 Gene

Regulatory Elements for CD58 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD58 Gene

Start:
116,514,534 bp from pter
End:
116,571,093 bp from pter
Size:
56,560 bases
Orientation:
Minus strand

Genomic View for CD58 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD58 Gene

Proteins for CD58 Gene

  • Protein details for CD58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19256-LFA3_HUMAN
    Recommended name:
    Lymphocyte function-associated antigen 3
    Protein Accession:
    P19256
    Secondary Accessions:
    • A8K7G5
    • Q5U053
    • Q6IB65
    • Q96KI9

    Protein attributes for CD58 Gene

    Size:
    250 amino acids
    Molecular mass:
    28147 Da
    Quaternary structure:
    • Interacts with CD2.

    Three dimensional structures from OCA and Proteopedia for CD58 Gene

    Alternative splice isoforms for CD58 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD58 Gene

Proteomics data for CD58 Gene at MOPED

Post-translational modifications for CD58 Gene

  • Glycosylation at Asn40, Asn94, Asn109, Asn135, Asn169, and Asn195
  • Modification sites at PhosphoSitePlus

Other Protein References for CD58 Gene

Antibody Products

No data available for DME Specific Peptides for CD58 Gene

Domains for CD58 Gene

Gene Families for CD58 Gene

HGNC:
  • CD :CD molecules

Protein Domains for CD58 Gene

Suggested Antigen Peptide Sequences for CD58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19256

UniProtKB/Swiss-Prot:

LFA3_HUMAN :
  • P19256
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD58: view

Function for CD58 Gene

Molecular function for CD58 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD58 (LFA-3),40-65kDa,identified by monoclonal antibodies G26,BRIC5,TS2/9,Ig superfamily,T cell restricted CD2 ligand
UniProtKB/Swiss-Prot Function:
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells

Gene Ontology (GO) - Molecular Function for CD58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 17344209
GO:0005515 protein binding IPI 7544493
genes like me logo Genes that share ontologies with CD58: view
genes like me logo Genes that share phenotypes with CD58: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD58

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CD58 Gene

Localization for CD58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD58 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD58 Gene COMPARTMENTS Subcellular localization image for CD58 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CD58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 7544493
GO:0009986 cell surface IDA 15345303
GO:0016020 membrane IDA 19946888
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CD58: view

Pathways for CD58 Gene

genes like me logo Genes that share pathways with CD58: view

Pathways by source for CD58 Gene

Interacting Proteins for CD58 Gene

Gene Ontology (GO) - Biological Process for CD58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion NAS 10380930
GO:0007596 blood coagulation TAS --
GO:0016337 single organismal cell-cell adhesion NAS 7544493
GO:0034113 heterotypic cell-cell adhesion IDA 15345303
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with CD58: view

Compounds for CD58 Gene

(16) Novoseek inferred chemical compound relationships for CD58 Gene

Compound -log(P) Hits PubMed IDs
alefacept 70.4 7
metronidazole 40.4 10
slex 30.4 2
rantes 9.41 1
lipid 1.98 1
genes like me logo Genes that share compounds with CD58: view

Transcripts for CD58 Gene

Unigene Clusters for CD58 Gene

CD58 molecule:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD58

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD58 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: -
SP2: - -
SP3:
SP4: - - -

Relevant External Links for CD58 Gene

GeneLoc Exon Structure for
CD58
ECgene alternative splicing isoforms for
CD58

Expression for CD58 Gene

mRNA expression in normal human tissues for CD58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD58 Gene

This gene is overexpressed in Whole Blood (4.9).

Protein differential expression in normal tissues for CD58 Gene

This gene is overexpressed in Bone marrow stromal cell (32.1) and Serum (12.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD58 Gene

SOURCE GeneReport for Unigene cluster for CD58 Gene Hs.34341

genes like me logo Genes that share expressions with CD58: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for CD58 Gene

Orthologs for CD58 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD58 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD58 35
  • 66.19 (n)
  • 49.05 (a)
CD58 36
  • 42 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD58 35
  • 98.4 (n)
  • 96.8 (a)
CD58 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD58 36
  • 49 (a)
OneToOne
Species with no ortholog for CD58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD58 Gene

ENSEMBL:
Gene Tree for CD58 (if available)
TreeFam:
Gene Tree for CD58 (if available)

Paralogs for CD58 Gene

No data available for Paralogs for CD58 Gene

Variants for CD58 Gene

Sequence variations from dbSNP and Humsavar for CD58 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs472291 -- 116,556,306(+) TTAAG(A/C)AGGTT intron-variant
rs548313 -- 116,545,482(+) actca(G/T)gagat intron-variant
rs601744 -- 116,549,166(+) ccttc(C/T)ttctt intron-variant
rs617742 -- 116,547,919(-) gtaca(C/T)tgctg intron-variant
rs758518 -- 116,539,188(+) AATAG(A/G)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD58 Gene

Variant ID Type Subtype PubMed ID
esv2512482 CNV Deletion 19546169
esv2209199 CNV Deletion 18987734
esv3433 CNV Deletion 18987735
esv2663968 CNV Deletion 23128226
esv2716607 CNV Deletion 23290073
esv7455 CNV Loss 19470904
esv267986 CNV Insertion 20981092
esv1003883 CNV Deletion 20482838

Relevant External Links for CD58 Gene

HapMap Linkage Disequilibrium report
CD58
Human Gene Mutation Database (HGMD)
CD58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD58 Gene

Disorders for CD58 Gene

(5) University of Copenhagen DISEASES for CD58 Gene

(42) Novoseek inferred disease relationships for CD58 Gene

Disease -log(P) Hits PubMed IDs
fowlpox 78.5 8
necrosis 48 12
tumors 42.6 35
paroxysmal hemoglobinuria nocturnal 42 3
lichen planus oral 33.9 4

Relevant External Links for CD58

Genetic Association Database (GAD)
CD58
Human Genome Epidemiology (HuGE) Navigator
CD58
genes like me logo Genes that share disorders with CD58: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CD58 Gene

Publications for CD58 Gene

  1. Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene. (PMID: 9510189) Wallich R. … Meuer S. (J. Immunol. 1998) 2 3 4 23
  2. Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution. (PMID: 10200255) Ikemizu S. … Davis S.J. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  3. The role of the CD58 locus in multiple sclerosis. (PMID: 19237575) De Jager P.L. … Hafler D.A. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23 48
  4. Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians. (PMID: 18650830) Rubio J.P. … Kilpatrick T.J. (Genes Immun. 2008) 3 48
  5. Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol- anchored proteins released upon phospholipase D treatment. (PMID: 16602701) Elortza F. … Jensen O.N. (J. Proteome Res. 2006) 3 4

Products for CD58 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CD58
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CD58
  • Block miRNA regulation of CD58 using miScript Target Protectors
  • Addgene plasmids for CD58

Sources for CD58 Gene

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