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CD58 Gene

protein-coding   GIFtS: 64
GCID: GC01M117059

CD58 Molecule

(Previous names: CD58 antigen, (lymphocyte function-associated antigen 3))
(Previous symbol: LFA3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD58 Molecule1 2     ag32
LFA31 2 3 5     Lymphocyte Function-Associated Antigen 32
CD58 Antigen, (Lymphocyte Function-Associated Antigen 3)1 2     Ag33
Surface Glycoprotein LFA-32 3     CD58 Antigen3
LFA-32     

External Ids:    HGNC: 16881   Entrez Gene: 9652   Ensembl: ENSG000001168157   OMIM: 1534205   UniProtKB: P192563   

Export aliases for CD58 gene to outside databases

Previous GC identifers: GC01M117560 GC01M115939 GC01M116204 GC01M116403 GC01M116758 GC01M116858 GC01M114916


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD58 Gene:
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte
CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma
membrane. Alternatively spliced transcript variants have been described. (provided by RefSeq, Jan 2009)

GeneCards Summary for CD58 Gene:
CD58 (CD58 molecule) is a protein-coding gene. Diseases associated with CD58 include hemoglobinuria, and lichen planus.

UniProtKB/Swiss-Prot: LFA3_HUMAN, P19256
Function: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte
interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with
target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the
LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD58 gene promoter:
         ER-alpha   CREB   PPAR-gamma1   IRF-2   Ik-2   deltaCREB   Lmo2   PPAR-gamma2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD58 promoter sequence
   Search Chromatin IP Primers for CD58

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD58


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13

CD58 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD58 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M117059:  view genomic region     (about GC identifiers)

Start:
117,057,156 bp from pter      End:
117,113,715 bp from pter
Size:
56,560 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CD58

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LFA3_HUMAN, P19256 (See protein sequence)
Recommended Name: Lymphocyte function-associated antigen 3 precursor  
Size: 250 amino acids; 28147 Da
Subunit: Interacts with CD2
3 PDB 3D structures from and Proteopedia for CD58:
1CCZ (3D)        1CI5 (3D)        1QA9 (3D)    
Secondary accessions: A8K7G5 Q5U053 Q6IB65 Q96KI9
Alternative splicing: 3 isoforms:  P19256-1   P19256-2   P19256-3   (GPI-anchor amidated asparagine on Asn-235. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CD58: NX_P19256

Explore proteomics data for CD58 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn40, Asn94, Asn109, Asn135, Asn169, Asn195

  • See CD58 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138294.1  NP_001770.1  

    ENSEMBL proteins: 
     ENSP00000358501   ENSP00000432773   ENSP00000409080   ENSP00000433648   ENSP00000358499  
    Reactome Protein details: P19256

    CD58 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals CD58 Lysate
    Sino Biological Recombinant Protein for CD58
    Sino Biological Cell Lysate for CD58
    ProSpec Recombinant Protein for CD58
    Browse Proteins at Cloud-Clone Corp.

    CD58 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CD58
    Browse Antibodies at Cloud-Clone Corp.
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    LSBio Antibodies in human, mouse, rat for CD58

    CD58 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    3 InterPro protein domains:
     IPR015714 Lymphocyte_func-assoc_Ag_3
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P19256

    ProtoNet protein and cluster: P19256

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: LFA3_HUMAN, P19256
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    CD58 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LFA3_HUMAN, P19256
    Function: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte
    interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with
    target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the
    LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells

         Genatlas biochemistry entry for CD58:
    cell differentiation antigen CD58 (LFA-3),40-65kDa,identified by monoclonal antibodies G26,BRIC5,TS2/9,Ig
    superfamily,T cell restricted CD2 ligand

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI17344209
    GO:0005515protein binding IPI7544493
         
    CD58 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CD58:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD58
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD58

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD58
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD58

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CD58 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CD58:
    hsa-miR-452* hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidCD58 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD58
    Predesigned siRNA for gene silencing in human, mouse, rat CD58

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CD58

    Clone
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    OriGene clones in human, mouse for CD58 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD58 (NM_001144822)
    Sino Biological Human cDNA Clone for CD58
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD58
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD58

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD58
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD58 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD58


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LFA3_HUMAN, P19256: Isoform 1: Cell membrane; Single-pass type I membrane protein
    LFA3_HUMAN, P19256: Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    lysosome1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS7544493
    GO:0009986cell surface IDA15345303
    GO:0031225anchored component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA--

    CD58 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD58 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Epstein-Barr virus infection
    Epstein-Barr virus infection
    3Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall
    4Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CD58
        Cell surface interactions at the vascular wall


    2 Kegg Pathways  (Kegg details for CD58):
        Cell adhesion molecules (CAMs)
    Epstein-Barr virus infection


    CD58 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD58
    Interactions:

        GeneGlobe Interaction Network for CD58

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for CD58 (P192562, 3 ENSP000003585014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202211 I2D: score=1 STRING: ENSP00000250416
    CD2P067293, ENSP000003584904I2D: score=4 STRING: ENSP00000358490
    DNAJA1P316893, ENSP000003691274I2D: score=4 STRING: ENSP00000369127
    HERPUD1Q150113I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS10380930
    GO:0007596blood coagulation TAS--
    GO:0016337cell-cell adhesion NAS7544493
    GO:0034113heterotypic cell-cell adhesion IDA15345303
    GO:0050900leukocyte migration TAS--

    CD58 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD58 (LFA3)

    Selected Novoseek inferred chemical compound relationships for CD58 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alefacept 70.4 8 17403057 (2), 17970892 (1), 11881524 (1), 12384938 (1) (see all 6)
    metronidazole 40.4 12 19009294 (2), 12384537 (1), 16081691 (1), 18197807 (1) (see all 9)
    slex 30.4 2 8838015 (1), 7576475 (1)
    rantes 9.41 1 15730495 (1)
    lipid 1.98 1 11884440 (1)
    lysine 0 2 15347975 (1)
    heparan sulfate 0 3 9891023 (1)
    phosphatidylinositol 0 4 1698448 (1), 1715960 (1)
    ganciclovir 0 2 8900310 (1)
    cisplatin 0 3 8816858 (2)



    CD58 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD58 gene (2 alternative transcripts): 
    NM_001144822.1  NM_001779.2  

    Unigene Cluster for CD58:

    CD58 molecule
    Hs.34341  [show with all ESTs]
    Unigene Representative Sequence: NM_001144822
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369489(uc001egm.3 uc001egn.3) ENST00000464088(uc001ego.1)
    ENST00000457047(uc010owy.2) ENST00000526981 ENST00000369487(uc001egp.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD58 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CD58:
    hsa-miR-452* hsa-miR-504
    SwitchGear 3'UTR luciferase reporter plasmidCD58 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD58
    Predesigned siRNA for gene silencing in human, mouse, rat CD58
    Clone
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    OriGene clones in human, mouse for CD58 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD58 (NM_001144822)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD58
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD58
    Primer
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    OriGene qPCR primer pairs and template standards for CD58
    OriGene qSTAR qPCR primer pairs in human, mouse for CD58
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CD58
      QuantiTect SYBR Green Assays in human, mouse, rat CD58
      QuantiFast Probe-based Assays in human, mouse, rat CD58

    Additional mRNA sequence: 

    AK291980.1 BC005930.1 BT019816.1 BT019817.1 CR456939.1 D28586.1 EF491785.1 NR_026665.1 
    S79616.1 X06296.1 Y00636.1 

    6 DOTS entries:

    DT.446694  DT.95269817  DT.92060021  DT.214662  DT.99999279  DT.205322 

    Selected AceView cDNA sequences (see all 109):

    BM979711 CA306215 BQ229508 AK125710 BM822426 D28586 CA312196 CA426675 
    NM_001779 BU626612 AW008902 BM833588 CA865722 CA312671 CR456939 AI289137 
    CA865476 BQ084474 CB145710 AA441868 Y00636 BQ083515 X06296 BI712917 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD58    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:                                            -                     
    SP2:                                            -     -               
    SP3:                                                                  
    SP4:                                -           -     -               


    ECgene alternative splicing isoforms for CD58

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD58 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGTGCTG
    CD58 Expression
    About this image


    CD58 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Adipose-derived stromal cells
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Adipose-derived stromal cells
     
     Testis (Reproductive System)
    CD58 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD58 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.34341
        Custom PCR Arrays for CD58
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD58
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    QuantiTect SYBR Green Assays in human, mouse, rat CD58
    QuantiFast Probe-based Assays in human, mouse, rat CD58
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD58

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for CD58 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CD586
    CD58 molecule
    49(a)
    1 ↔ 1
    17(53973029-53995788)


    ENSEMBL Gene Tree for CD58 (if available)
    TreeFam Gene Tree for CD58 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD58 (see all 919)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108021891,2
    C,F,A,H--117056730(+) GCTGCT/CAGAGG 2 -- ds500123Minor allele frequency- C:0.34NS EA NA WA CSA 2352
    rs1920563221,2
    --117056746(+) GGCACC/TGTCCA 2 -- ds50010--------
    rs1135552241,2
    C,F--117056747(+) GCACCG/ATCCAC 2 -- ds50012Minor allele frequency- A:0.06CSA WA 120
    rs1137825951,2
    F--117056985(+) GCCTCG/ATACTG 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1834250741,2
    --117057046(+) ATGACA/CCTACA 2 -- ds50010--------
    rs1871141111,2
    --117057074(+) TAAAGA/CAAGGG 2 -- ds50010--------
    rs790508361,2
    C--117057356(+) TGTAAC/TACTCA 2 -- ut31 nc-transcript-variant0--------
    rs1997175201,2
    --117057410(+) TATGCC/TGTTGT 2 -- ut31 nc-transcript-variant0--------
    rs1172848651,2
    F--117057615(+) GCTCTT/CGGGAT 2 -- int11Minor allele frequency- C:0.02EA 120
    rs1900453881,2
    --117057667(+) GCACTC/TAATAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for CD58 (117057156 - 117113715 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CD58:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663968CNV Deletion23128226
    esv2512482CNV Deletion19546169
    esv2716607CNV Deletion23290073
    esv2209199CNV Deletion18987734
    esv1003883CNV Deletion20482838
    esv3433CNV Deletion18987735
    esv267986CNV Insertion20981092
    esv7455CNV Loss19470904

    Human Gene Mutation Database (HGMD): CD58
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD58
    DNA2.0 Custom Variant and Variant Library Synthesis for CD58

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153420    OMIM disorders: --

    Selected diseases for CD58 (see all 55):    
    About MalaCards
    hemoglobinuria    lichen planus    primary effusion lymphoma    glanders
    paroxysmal nocturnal hemoglobinuria    oral lichen planus    cholera    hemorrhagic fever with renal syndrome
    hepatitis b    vaccinia    psoriatic arthritis    hepatitis b virus infection
    viral hepatitis    multiple sclerosis    liver disease    protein s deficiency
    human t-cell leukemia virus type 1    squamous cell carcinoma of the head and neck    tetanus    acute leukemia

    5 diseases from the University of Copenhagen DISEASES database for CD58:
    Vaccinia     Leukemia     Psoriasis     Tetanus
    Lymphoma

    CD58 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CD58 gene (see all 42)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fowlpox 78.5 9 12384537 (1), 15010371 (1), 16451103 (1), 18483372 (1) (see all 8)
    necrosis 48 14 1906507 (1), 7523228 (1), 1718801 (1), 7686816 (1) (see all 12)
    tumors 42.6 53 8592403 (3), 8816858 (2), 10094205 (2), 7690630 (2) (see all 30)
    paroxysmal hemoglobinuria nocturnal 42 5 1688724 (2), 9516159 (1)
    lichen planus oral 33.9 6 8705826 (2), 10564548 (1), 9708688 (1)
    leukemia lymphocytic chronic 32.4 1 19009294 (1)
    myeloma 29.4 10 1382543 (2), 8797890 (2), 7861616 (1)
    melanoma 27.6 22 7685328 (4), 7686816 (4), 9651826 (2), 1689276 (2) (see all 10)
    psoriasis 27.6 3 1654990 (1), 17403057 (1)
    arthritis psoriatic 26.6 1 12384938 (1)

    Genetic Association Database (GAD): CD58
    Human Genome Epidemiology (HuGE) Navigator: CD58 (20 documents)

    Export disorders for CD58 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD58 gene, integrated from 10 sources (see all 381):
    (articles sorted by number of sources associating them with CD58)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene. (PubMed id 9510189)1, 2, 3, 9 Wallich R.... Meuer S. (J. Immunol. 1998)
    2. The role of the CD58 locus in multiple sclerosis. (PubMed id 19237575)1, 4, 9 De Jager P.L....Hafler D.A. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    3. Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution. (PubMed id 10200255)1, 2, 9 Ikemizu S.... Davis S.J. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    4. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PubMed id 22190364)1, 4 Patsopoulos N.A....de Bakker P.I. (Ann. Neurol. 2011)
    5. Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis. (PubMed id 20806065)1, 4 Ryckman K.K....Hennig B.J. (PLoS ONE 2010)
    6. Multiple sclerosis susceptibility alleles in African Americans. (PubMed id 19865102)1, 4 Johnson B.A....Oksenberg J.R. (Genes Immun. 2010)
    7. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. (PubMed id 19525955)1, 4 (Nat. Genet. 2009)
    8. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PubMed id 19879194)1, 4 De Jager P.L....Karlson E.W. (Lancet Neurol 2009)
    9. Risk alleles for multiple sclerosis in multiplex families. (PubMed id 19506219)1, 4 D'Netto M.J....Ebers G.C. (Neurology 2009)
    10. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 965 HGNC: 1688 AceView: CD58 Ensembl:ENSG00000116815 euGenes: HUgn965
    ECgene: CD58 Kegg: 965 H-InvDB: CD58

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD58 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD58 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD58 gene:
    Search GeneIP for patents involving CD58

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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