Aliases for CD58 Gene
External Ids for CD58 Gene
Previous HGNC Symbols for CD58 Gene
Previous GeneCards Identifiers for CD58 Gene
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
GeneCards Summary for CD58 Gene
CD58 (CD58 Molecule) is a Protein Coding gene. Diseases associated with CD58 include Whipple Disease and Cortical Thymoma. Among its related pathways are Platelet activation, signaling and aggregation and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. GO annotations related to this gene include receptor binding.
UniProtKB/Swiss-Prot for CD58 Gene
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.