CD58 Gene

Aliases
for CD58 gene

Previous GC identifers: GC01M117560 GC01M115939 GC01M116204 GC01M116403 GC01M116758 GC01M116858 GC01M114916

Summaries
for CD58 gene

Genomic Views
for CD58 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_032977.9  

SwitchGear Promoter luciferase reporter plasmid: CD58 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD58

CD58 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M117059:  view genomic region     (about GC identifiers)

Proteins
for CD58 gene

3 PDB 3D structures from and Proteopedia for CD58:

1CCZ (3D)        1CI5 (3D)        1QA9 (3D)    

Explore the universe of human proteins at neXtProt for CD58: NX_P19256

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD58 (CD58/LFA-3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CD58
	GenScript Custom Purified and Recombinant Proteins Services for CD58
	Novus Biologicals CD58 Proteins Novus Biologicals CD58 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CD58
	Uscn Proteins for CD58

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD58
	R&D Systems Antibodies for CD58 (CD58/LFA-3)
	OriGene Antibodies: CD58 OriGene Custom Antibody Services for CD58
	GenScript Custom Superior Antibodies Services for CD58
	Novus Biologicals CD58 Antibodies
	Abcam antibodies for CD58
	Uscn Antibodies for CD58
	ThermoFisher Antibody for CD58

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CD58 (CD58/LFA-3)
	GenScript Custom Assay Services for CD58
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD58

Protein Domains /
Families
for CD58 gene

ProtoNet protein and cluster: P19256

Function
for CD58 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD58 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD58
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CD58:
		hsa-miR-452* hsa-miR-504
		SwitchGear 3'UTR luciferase reporter plasmid: CD58 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD58 OriGene shRNA RFP: CD58 OriGene siRNA: CD58
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD58

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD58

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD58 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD58 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD58 (NM_001144822)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD58
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD58

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD58
		Search LifeMap BioReagents cell lines for CD58

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD58

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

Pathways & Interactions
for CD58 gene

	Super-pathway	contained gene-specific pathways
1	Cell adhesion molecules (CAMs)	Cell adhesion molecules (CAMs) 1.00
2	Cell surface interactions at the vascular wall	Cell surface interactions at the vascular wall 1.00
3	Platelet activation, signaling and aggregation	Hemostasis 0.43

2        Reactome Pathways for CD58

	Hemostasis
	Cell surface interactions at the vascular wall

1         Kegg Pathway  (Kegg details for CD58)

Cell adhesion molecules (CAMs)

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CD58 gene

Transcripts
for CD58 gene

Expression
for CD58 gene

CD58 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTGTGCTG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD58 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD58
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD58
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD58

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD58

Orthologs
for CD58 gene

Paralogs
for CD58 gene

Genomic Variants
for CD58 gene

10/860 NCBI SNPs in CD58 are shown (see all 860)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs108021891,2	C,F,A,H,	--	117056730(+)	GCTGCT/CAGAGG	2	--	ds5001		23		NS EA NA WA CSA	2352
rs1920563221,2		--	117056746(+)	GGCACC/TGTCCA	2	--	ds5001		0	--	--	--	--
rs1135552241,2		--	117056747(+)	GCACCG/ATCCAC	2	--	ds5001		2		CSA WA	120
rs1137825951,2		--	117056985(+)	GCCTCG/ATACTG	2	--	ds5001		1		CSA	2
rs1834250741,2		--	117057046(+)	ATGACA/CCTACA	2	--	ds5001		0	--	--	--	--
rs1871141111,2		--	117057074(+)	TAAAGA/CAAGGG	2	--	ds5001		0	--	--	--	--
rs790508361,2		--	117057356(+)	TGTAAC/TACTCA	2	--	ut31 nc-transcript-variant		0	--	--	--	--
rs1997175201,2		--	117057410(+)	TATGCC/TGTTGT	2	--	ut31 nc-transcript-variant		0	--	--	--	--
rs1172848651,2	F,	--	117057615(+)	GCTCTT/CGGGAT	2	--	int1		1		EA	120
rs1900453881,2		--	117057667(+)	GCACTC/TAATAG	2	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD58 (117057156 - 117113715 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CD58
     1 CNV: 97480
     3 Indels: 60874 44438 42638
Human Gene Mutation Database (HGMD): CD58

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD58

DNA2.0 Custom Variant and Variant Library Synthesis for CD58

Disorders / Diseases
for CD58 gene

20/54 diseases for CD58

10/42 Novoseek disease relationships for CD58 gene (see all 42)    About this table

Publications
for CD58 gene

PubMed articles for CD58 gene, integrated from 9 sources (see all 376): (articles sorted by number of sources associating them with CD58)

Utopia: connect your pdf to the dynamic world of online information

1. Gene structure, promoter characterization, and basis for alternative mRNA splicing of the human CD58 gene. (PubMed id 9510189)^{1, 2, 3, 9} Wallich R.... Meuer S. (1998)
2. Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution. (PubMed id 10200255)^{1, 2, 9} Ikemizu S.... Davis S.J. (1999)
3. Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol- anchored proteins released upon phospholipase D treatment. (PubMed id 16602701)^{1, 2} Elortza F.... Jensen O.N. (2006)
4. Primary structure of lymphocyte function-associated antigen 3 (LFA- 3). The ligand of the T lymphocyte CD2 glycoprotein. (PubMed id 3309127)^{1, 2} Wallner B.P.... Springer T.A. (1987)
5. An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2. (PubMed id 3313052)^{1, 2} Seed B. (1987)
6. Soluble and cell-associated forms of the adhesion molecule LFA-3 (CD58) are differentially regulated by inflammatory cytokines. (PubMed id 11051456)^{1, 9} Kirby A.C....Olsen I. (2000)
7. The role of the CD58 locus in multiple sclerosis. (PubMed id 19237575)^{1, 9} De Jager P.L....Hafler D.A. (2009)
8. Expression and function of lymphocyte function associated antigen-3 (LFA-3) at the blood-brain barrier. (PubMed id 10099837)^{1, 9} Omari K.I. and Dorovini-Zis K. (1999)
9. The complement inhibitor CD59 and the lymphocyte function-associated antigen-3 (LFA-3, CD58) genes possess functional binding sites for the p53 tumor suppressor protein. (PubMed id 12553064)^{1, 9} Gazouli M....Gorgoulis V. (2002)
10. CD58 (LFA-3) stimulation provides a signal for human isotype switching and IgE production distinct from CD40. (PubMed id 7515920)^{1, 9} Diaz-Sanchez D....Saxon A. (1994)

External Searches for CD58 gene

Genome Databases showing CD58 gene

Other Databases showing CD58 gene

Specialized Databases showing CD58 gene

Products
for CD58 gene