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CD55 Gene

protein-coding GIFtS: 63

GC01P205561

CD55 molecule, decay accelerating factor for complement (Cromer blood group)
(Previous names: decay accelerating factor for complement (CD55, Cromer blood group system) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: DAF)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CR ^¹, ², ³
CROM ^², ⁵
DAF ^², ³, ⁵
TC ^¹, ²

Descriptions
CD55 antigen ^², ³
CD55 molecule, decay accelerating factor for complement (Cromer blood group) ^²
decay accelerating factor for complement ^²
decay accelerating factor for complement (CD55, Cromer blood group system) ^¹

External Ids
HGNC: 2665¹
Entrez Gene: 1604²
UniProtKB: P08174³
Ensembl: ENSG00000196352⁷

Search outside databases for aliases for CD55 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CD55:

This gene encodes a protein involved in the regulation of the complement cascade. The encoded

glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement

proteins accelerates their decay, disrupting the cascade and preventing damage to host cells.

Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two

alternatively spliced transcripts encoding different proteins have been identified. The

predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma

component proteins but an alternatively spliced transcript produces a soluble protein present at

much lower levels. Additional, alternatively spliced transcript variants have been described, but

their biological validity has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174

Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or

amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation.

Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to

catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents

the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade

Gene Wiki entry for CD55 (Decay_accelerating_factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CD55 gene

Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32

CD55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P205561: (about GC identifiers)

Start:	205,561,488 bp from pter
End:	205,600,934 bp from pter
Size:	39,447 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_021877.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174 (See protein sequence)

Recommended Name: Complement decay-accelerating factor precursor

Size: 381 amino acids; 41400 Da

Subunit: Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Binds to

coxsackievirus A21, coxsackieviruses B1, B3 and B5, human enterovirus 70, human echoviruses 6, 7,

11, 12, 20 and 21 capsid proteins and acts as a receptor for these viruses

Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor

PDB structures from and Proteopedia :

1H03 (3D)

1H04 (3D)

1H2P (3D)

1H2Q (3D)

1M11 (3D)

1NWV (3D)

1OJV (3D)

1OJW (3D)

1OJY (3D)

1OK1 (3D)

1OK2 (3D)

1OK3 (3D)

1OK9 (3D)

1UOT (3D)

1UPN (3D)

2C8I (3D)

2QZD (3D)

2QZF (3D)

2QZH (3D)

Secondary accessions: P09679 P78361

Alternative splicing: 2 isoforms: P08174-1 P08174-2

Post-translational modifications:

The Ser/Thr-rich domain is heavily O-glycosylated¹

REFSEQ proteins (2 alternative transcripts):

NP_000565.1 NP_001108224.1

ENSEMBL proteins:

ENSP00000316333 ENSP00000356032 ENSP00000356034 ENSP00000340631 ENSP00000375788 ENSP00000356031

ENSP00000375787 ENSP00000356030 ENSP00000356029

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for CD55 (CD55/DAF)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD55)
	Human Recombinant Proteins from Abnova (DAF)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	TAS	2433596
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	2433596
GO:0031225	anchored to membrane	IEA	--
GO:0045121	membrane raft	IDA	11313396

About this table

Antibodies for CD55:

	Invitrogen Antibodies for CD55
	Millipore Mono- and Polyclonal Antibodies for the study of CD55
	Sigma-Aldrich Antibodies for CD55
	R&D Systems Antibodies for CD55 (CD55/DAF)
	Antibodies from Abcam (CD55), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DAF)
	Novus Biologicals Antibodies for CD55

Assays for CD55:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08174

ProtoNet protein and cluster: P08174

1 Blocks protein family: IPB000436 Sushi domain/SCR domain/CCP module

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174

Domain: The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the

proper conformation for the active site on SCR3 (By similarity)

Similarity: Belongs to the receptors of complement activation (RCA) family

Similarity: Contains 4 Sushi (CCP/SCR) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD55)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DAF)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000574

Applied Biosystems Silencer® siRNAs for CD55

Sigma-Aldrich siRNA for CD55

Sigma-Aldrich shRNA for CD55

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CD55
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000574
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000574
untagged cDNA clones in CMV expression vector (see all 3): NM_000574

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001114752

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174

Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or

amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation.

Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to

catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents

the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd55):

hematopoietic system

homeostasis/metabolism

immune system

renal/urinary system

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for CD55 (Your Favorite Gene powered by Ingenuity)

Caveolar-mediated Endocytosis
Virus Entry via Endocytic Pathways
Complement System

GeneDecks CD55 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CD55

5/38 Interacting proteins for CD55 (ENSP00000356030³) via UniProtKB, MINT, and/or STRING (see all 38 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD97	ENSP00000242786³	STRING (score=.997)
EMR2	ENSP00000319883³	STRING (score=.986)
C3	ENSP00000245907³	STRING (score=.973)
CD59	ENSP00000340210³	STRING (score=.962)
EMR1	ENSP00000370814³	STRING (score=.94)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006958	complement activation, classical pathway	IEA	--
GO:0007204	elevation of cytosolic calcium ion concentration	IDA	8223854
GO:0045087	innate immune response	IEA	--
GO:0045730	respiratory burst	NAS	8223854

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CD55
10/29 Novoseek chemical compound relationships for CD55 gene (see all 29 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dafs	79.66	4	1700997 (1), 1712233 (1), 10906393 (1)
phosphatidylinositol	42.83	29	1702821 (2), 2182938 (1), 7691484 (1), 7527236 (1) (see all 13)
glycolipid	42.17	10	7687624 (2), 1691902 (1), 7615819 (1), 7527603 (1) (see all 7)
sucrose	14.12	7	19152664 (2), 12186694 (1), 1378912 (1), 10611479 (1) (see all 5)
sialic acid	5.34	5	1716283 (2), 1702821 (1)
atp	5.31	2	7510241 (1), 19154662 (1)
fatty acid	5.06	1	1370460 (1)
iron	4.83	3	19036700 (1), 11930678 (1)
oligonucleotide	4.82	2	9648070 (1)
nitric oxide	1.42	6	15102803 (5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD55)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DAF)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_000574

Sigma-Aldrich siRNA for CD55

Sigma-Aldrich shRNA for CD55

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000574 NM_001114752

REFSEQ mRNAs for CD55 gene (2 alternative transcripts):

NM_000574.3 NM_001114752.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000574 NM_001114752

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000574
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000574
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000574

Additional cDNA sequence:

AB240566.1 AB240567.1 AB240568.1 AB240569.1 AB240570.1 AF052110.1 AK298549.1 AK300621.1

AK312448.1 AY055757.1 AY055758.1 AY055759.1 AY055760.1 BC001288.1 BT007159.1 CR596368.1

CR596647.1 CR600235.1 CR603699.1 CR611789.1 CR613044.1 CR623902.1 CR624858.1 M15799.1

M30142.1 M31516.1 U88576.1

24/30 DOTS entries (see all 30 ):

DT.454114 DT.98083655 DT.100827194 DT.80100435 DT.100827202 DT.100827205 DT.75189288 DT.121461699

DT.92456135 DT.99931303 DT.121461669 DT.100827208 DT.121461696 DT.100827193 DT.92456145 DT.121461683

DT.97854983 DT.100827204 DT.121461679 DT.91677250 DT.100714519 DT.100809320 DT.100827192 DT.121461660

24/520 AceView cDNA sequences (see all 520 ):

H16044 BE049467 BQ221579 AL550277 AV703570 BQ231176 BC001288 CA843365

CR624858 BQ233015 BQ221490 BP353106 BP353891 CR596368 H56567 CB217037

BF665958 AF052110 CK822926 BP365936 CA748776 AI888485 CR600235 CR611789

highest scoring ESTs for CD55:

M31516 AA086067 AA112358 AA156547 AA186360 AA188660 AA190635 AA192424 AA216711 AA262302

Unigene Cluster for CD55:

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

Hs.126517 [show with all ESTs]

Unigene Representative Sequence: NM_001114752

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CD55 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12
SP1:							-		-														-										-				-
SP2:																							-
SP3:																							-										-
SP4:							-		-						-								-
SP5:																							-

About this scheme

ECgene alternative splicing isoforms for CD55

9 Ensembl transcripts including schematic representations:

ENST00000314754 ENST00000367065 ENST00000367067 ENST00000343420 ENST00000391921 ENST00000367064

ENST00000391920 ENST00000367063 ENST00000367062

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CD55 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CD55

¹ / ² / ³

7 probe-sets matching CD55 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39695_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.55	M31516	1.00	1.00	1.00	1
66294_at²^{, 3}	U95-C	1	0.94	1.00	0.83	0.48	AI888485	0.60	1.00	0.82	1
201925_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000574	0.60	1.00	0.82	1
201926_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC001288	0.80	1.00	0.91	1
1555950_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201925_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201926_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CD55 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAAACAAGA

SOURCE GeneReport for Unigene cluster: Hs.126517
UniProtKB/Swiss-Prot: DAF_HUMAN, P08174
Tissue specificity: Expressed on the plasma membranes of all cell types that are in intimate
contact with plasma complement proteins. It is also found on the surfaces of epithelial cells
lining extracellular compartments, and variants of the molecule are present in body fluids and in
extracellular matrix

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CD55 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CD55¹	--	CD55 molecule, decay accelerating factor for complement more	72.26(n) 62.5(a)	609307 XM_846545.1 XP_851638.1
cow (Bos taurus)	CD55¹	--	CD55 molecule, decay accelerating factor for complement more	73.46(n) 58.25(a)	518609 NM_001030303.1 NP_001025474.1
rat (Rattus norvegicus)	Cd55¹	--	Cd55 molecule	64.3(n) 49.72(a)	64036 NM_022269.2 NP_071605.2
mouse (Mus musculus)	Cd55⁵	1 (67.60 cM)	CD55 antigen	--	L41501

About this table Species with no ortholog for CD55

ENSEMBL Gene Tree for CD55

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CD55 gene

CR1L² CR2² C4BPA² CD46² CR1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174

Polymorphism: Responsible for the Cromer blood group system. It consists of at least 8

high-incidence (Cr(a), Tc(a), Dr(a), Es(a), WES(b), UMC, IFC and GUTI) and three low-incidence

(Tc(b), Tc(c) and WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab

there is reduced or absent expression of DAF, respectively. In the case of the Dr(a-) phenotype, a

single nucleotide substitution within exon 5 accounts for two changes: a simple amino acid

substitution, Leu-199 that is the basis of the antigenic variation, and an alternative splicing

event that underlies the decreased expression of DAF in this phenotype. The Inab phenotype is a

very rare one in which the red blood cells lack all Cromer system antigens. The red blood cells of

individuals with Inab phenotype have a deficiency of DAF, but these individuals are not known to

have any associated hematologic or other abnormalities

10/21332 NCBI SNPs in CD55 are shown (see all 21332 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 170)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs28371655^1,2	C,F	205600081(+)	`CCTTCG/AGGTTG`	2	--	ut3¹		8	NS	744
	rs28371672^1,2	F	205599778(+)	`CCTACA/CCCTCT`	2	--	ut3¹ ese³		2	NS	86
	rs28371656^1,2	F	205600546(+)	`TCCTAC/AAAGCA`	2	--	ut3¹ ese³		2	NS	86
--	rs12024498^1,2	H	205599605(+)	`AATACA/CCACAA`	2	T/P	mis¹ ut3¹ ese³		4	EU EA WA	404
	rs12135160^1,2	H	205577318(+)	`TGTTTC/TCAGGA`	2	S/F	mis¹ ese³		4	EU EA WA	420
	rs925130^1,2	A,C,F,H,O	205570055(+)	`TTTGCA/GCTTCC`	1	--	int¹		5	MN EU WA NS	506
	rs1507760^1,2	A,C,F,H,O	205575988(+)	`GGGGAT/CTTTGT`	1	--	int¹		14	MN NA NS EU EA WA	1252
	rs925131^1,2	A,C,F,H,O	205570344(+)	`ATGTGG/AAACCA`	1	--	int¹		17	NA EA MN NS EU WA	1432
	rs1507759^1,2	A,C,F,H	205574251(+)	`acccaA/Gttaat`	1	--	int¹		6	EU EA WA NS	504
	rs4844592^1,2	A,C,F,H	205567834(+)	`CTACCA/TTTTTT`	1	--	int¹ trp³		10	NS EU EA WA	924

About this table

HapMap Linkage Disequilibrium images for CD55 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 125240

10/96 Novoseek disease relationships for CD55 gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
paroxysmal hemoglobinuria nocturnal	92.04	37	19154662 (2), 1688570 (1), 9516159 (1), 1281489 (1) (see all 30)
hemolysis	66.24	27	9203959 (2), 1378912 (2), 11881969 (2), 7691484 (1) (see all 18)
anemia aplastic	58.28	4	7544152 (2), 7686037 (1), 11930678 (1)
hemoglobinuria	56.73	2	9844822 (1), 10539884 (1)
swine vesicular disease	49.15	1	15831949 (1)
anemia hemolytic	47.19	5	11930678 (1), 9892684 (1), 12213736 (1)
somatic mutations	42.55	2	18376800 (1), 7522635 (1)
anemia dyserythropoietic congenital	38.96	1	7506081 (1)
enterovirus infections	35.09	1	15507656 (1)
autoimmune hemolytic anemia	34.38	3	11930678 (1), 18954403 (1), 17289551 (1)

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Blood Group Antigen Gene Mutation Database (BGMUT) Cromer blood group system

Human Gene Mutation Database: CD55
Human Genome Epidemiology Navigator: CD55 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/565 PubMed articles for CD55 gene (see all 565 ):

Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. (PubMed id 7519480)^{1, 3, 4} Lublin D.M.... Tanner M.J.A. (1994)
Isolation of two forms of decay-accelerating factor (DAF) from human urine. (PubMed id 1712233)^{1, 3, 4} Nakano Y.... Tomita M. (1991)
Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol- anchored proteins released upon phospholipase D treatment. (PubMed id 16602701)^{3, 4} Elortza F.... Jensen O.N. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complement regulation at the molecular level: the structure of decay- accelerating factor. (PubMed id 14734808)^{3, 4} Lukacik P....Lea S.M. (2004)
GUTI: a new antigen in the Cromer blood group system. (PubMed id 12675719)^{3, 4} Storry J.R.... Reid M.E. (2003)
Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A. (PubMed id 12499389)^{3, 4} Williams P.... Lea S. (2003)
Solution structure of a functionally active fragment of decay- accelerating factor. (PubMed id 12672958)^{3, 4} Uhrinova S....Barlow P.N. (2003)
Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins. (PubMed id 14517339)^{3, 4} Elortza F....Jensen O.N. (2003)
Decay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immuno-focal cloning method. (PubMed id 7525274)^{3, 4} Ward T....Almond J.W. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1604	HGNC: 2665	AceView: DAF	Ensembl:ENSG00000196352	euGenes: HUgn1604
ECgene: CD55	H-InvDB: CD55

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=cromer
CD55base	http://bioinf.uta.fi/CD55base/
Wikipedia	http://en.wikipedia.org/wiki/Decay_accelerating_factor
SeattleSNPs	http://pga.gs.washington.edu/data/daf/
Virus Particle ExploreR db	http://viperdb.scripps.edu/info_page.php?VDB=1upn

Licensable Technologies for CD55
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CD55:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CD55-related products

	Millipore Custom Antibody & Bulk Services
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CD55 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for CD55

Summaries
for CD55

Genomic Location
for CD55

Proteins
for CD55

Protein Domains/
Families
for CD55

Gene Function
for CD55

Pathways & Interactions
for CD55

Drugs & Compounds
for CD55

Transcripts
for CD55

Expression
for CD55

Orthologs
for CD55

Paralogs
for CD55

SNPs/Variants
for CD55

Disorders & Mutations
for CD55

Medical News
for CD55

Publications
for CD55

Search for CD55

Genome Databases showing CD55

Other Databases showing CD55

Specialized Databases showing CD55

Licensable Technologies
for CD55

Services
for CD55

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CD55 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor CD55

Summariesfor CD55

Genomic Locationfor CD55

Proteinsfor CD55

Protein Domains/Familiesfor CD55

Gene Functionfor CD55

Pathways & Interactionsfor CD55

Drugs & Compoundsfor CD55

Transcriptsfor CD55

Expression for CD55

Orthologsfor CD55

Paralogsfor CD55

SNPs/Variantsfor CD55

Disorders & Mutationsfor CD55

Medical Newsfor CD55

Publicationsfor CD55

Search for CD55

Genome Databases showing CD55

Other Databases showing CD55

Specialized Databases showing CD55

Licensable Technologiesfor CD55

Servicesfor CD55

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CD55

Summaries
for CD55

Genomic Location
for CD55

Proteins
for CD55

Protein Domains/
Families
for CD55

Gene Function
for CD55

Pathways & Interactions
for CD55

Drugs & Compounds
for CD55

Transcripts
for CD55

Expression
for CD55

Orthologs
for CD55

Paralogs
for CD55

SNPs/Variants
for CD55

Disorders & Mutations
for CD55

Medical News
for CD55

Publications
for CD55

Licensable Technologies
for CD55

Services
for CD55