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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD55 Gene

protein-coding GIFtS: 65
GCID: GC01P207494

CD55 molecule, decay accelerating factor for complement...

(Previous names: decay accelerating factor for complement (CD55, Cromer...)
(Previous symbol: DAF)

Explore 110 diseases affiliated with
CD55 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD55 Molecule, Decay Accelerating Factor For Complement (Cromer Blood Group)¹ ²		TC¹ ²
DAF¹ ² ³ ⁵		CD55 Antigen² ³
CR¹ ² ³		Decay Accelerating Factor For Complement (CD55, Cromer Blood Group System)¹
CROM¹ ² ⁵		Complement Decay-Accelerating Factor²

External Ids:	HGNC: 2665¹	Entrez Gene: 1604²	Ensembl: ENSG00000196352⁷	OMIM: 125240⁵	UniProtKB: P08174³

Export aliases for CD55 gene to outside databases

Previous GC identifers: GC01P205561 GC01P178191

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD55:

This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also

known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay,

disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the

Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been

identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component

proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional,

alternatively spliced transcript variants have been described, but their biological validity has not been determined.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174

Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when

nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and

C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active

C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement

cascade

Gene Wiki entry for CD55 (Decay-accelerating factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD55 gene promoter:
SRF TBP SRY SRF (504 AA)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD55 promoter sequence

Search SABiosciences Chromatin IP Primers for CD55

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD55

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32

CD55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD55 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P207494: view genomic region (about GC identifiers)

Start:	207,494,817 bp from pter	End:	207,534,311 bp from pter
Size:	39,495 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174 (See protein sequence)

Recommended Name: Complement decay-accelerating factor precursor

Size: 381 amino acids; 41400 Da

Subunit: Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Binds to coxsackievirus A21,

coxsackieviruses B1, B3 and B5, human enterovirus 70, human echoviruses 6, 7, 11, 12, 20 and 21 capsid proteins and

acts as a receptor for these viruses

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor

6/21 PDB 3D structures from and Proteopedia for CD55 (see all 21):

1H03 (3D)

1H04 (3D)

1H2P (3D)

1H2Q (3D)

1M11 (3D)

1NWV (3D)

Secondary accessions: B1AP14 D3DT83 D3DT84 P09679 P78361

Alternative splicing: 2 isoforms: P08174-1 P08174-2

Explore the universe of human proteins at neXtProt for CD55: NX_P08174

Post-translational modifications:

The Ser/Thr-rich domain is heavily O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08174

CD55 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000565.1 NP_001108224.1

ENSEMBL proteins:

ENSP00000356031 ENSP00000356030 ENSP00000375788 ENSP00000316333 ENSP00000433984

ENSP00000340631 ENSP00000356032 ENSP00000375787 ENSP00000356029 ENSP00000356034

Reactome Protein details: P08174
Human Recombinant Protein Products:

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	Novus Biologicals CD55 Proteins Novus Biologicals CD55 Lysates
	Sino Biological Recombinant Protein for CD55
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD55

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005625	soluble fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	2433596
GO:0009986	cell surface	IDA	15907827

CD55 for ontologies About GeneDecksing

CD55 Antibody Products:

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	Novus Biologicals CD55 Antibodies
	Abcam antibodies for CD55
	Uscn Antibodies for CD55
	ThermoFisher Antibody for CD55

Assay Products for CD55:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD55
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD55

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD55 for domains About GeneDecksing

1 InterPro domain/family:

IPR000436 Sushi_SCR_CCP

Graphical View of Domain Structure for InterPro Entry P08174

ProtoNet protein and cluster: P08174

1 Blocks protein family: IPB000436 Sushi domain/SCR domain/CCP module

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174

Domain: The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for

the active site on SCR3 (By similarity)

Similarity: Belongs to the receptors of complement activation (RCA) family

Similarity: Contains 4 Sushi (CCP/SCR) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174

Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when

nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and

C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active

C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement

cascade

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD55 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD55
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		hsa-miR-3658 hsa-miR-513a-3p hsa-miR-578 hsa-miR-138-2*
		SwitchGear 3'UTR luciferase reporter plasmid: CD55 3' UTR sequence

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Gene Editing
Products:

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD55
		Search LifeMap BioReagents cell lines for CD55

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD55

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004857	enzyme inhibitor activity	IEA	--
GO:0004872	receptor activity	--	--

CD55 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CD55: Cd55^tm1Mme Cd55^tm1Song
     8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd55):

behavior/neurological	growth/size	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	muscle	renal/urinary system

CD55 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_Alternative complement pathway

	Immune response Alternative complement pathway	1.00			Immune response_Lectin induced complement pathway	0.56
	Immune response_Alternative complement pathway	1.00			Immune response Lectin Induced complement pathway	0.56

Immune response_Classical complement pathway

Immune response_Classical complement pathway

1.00

Immune response Classic complement pathway

0.98

Immune System

Immune System

1.00

Innate Immune System

0.46

Signaling by GPCR

Signaling by GPCR

1.00

Signal Transduction

0.56

Hematopoietic cell lineage

Hematopoietic cell lineage

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CD55

	Immune response Alternative complement pathway
	Immune response Classic complement pathway
	Immune response Lectin Induced complement pathway

3 GeneGo (Thomson Reuters) Pathways for CD55

	Immune response Alternative complement pathway
	Immune response Classical complement pathway
	Immune response Lectin induced complement pathway

1 BioSystems Pathway for CD55

Complement Activation, Classical Pathway

5/8 Reactome Pathways for CD55 (see all 8)

	Signaling by GPCR
	GPCR ligand binding
	Signal Transduction
	Regulation of Complement cascade
	Innate Immune System

3 Kegg Pathways (Kegg details for CD55):

	Complement and coagulation cascades
	Hematopoietic cell lineage
	Viral myocarditis

CD55 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD55

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for CD55 (P08174³ ENSP00000316333⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD97	P48960³, ENSP00000242786⁴	I2D: score=2 STRING: ENSP00000242786
FYN	P06241³, ENSP00000357656⁴	I2D: score=2 STRING: ENSP00000357656
LCK	P06239³, ENSP00000337825⁴	I2D: score=2 STRING: ENSP00000337825
CD14	P08571³, ENSP00000304236⁴	I2D: score=2 STRING: ENSP00000304236
CR1	P17927³, ENSP00000356016⁴	I2D: score=2 STRING: ENSP00000356016

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006958	complement activation, classical pathway	IEA	--
GO:0007204	elevation of cytosolic calcium ion concentration	IDA	8223854
GO:0007283	spermatogenesis	IEA	--
GO:0030449	regulation of complement activation	TAS	--
GO:0043434	response to peptide hormone stimulus	IEA	--

CD55 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD55 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD55

1 DrugBank Compound for CD55 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Chloramphenicol	CAF (see all 7)	56-75-7	target	other	17376081 15331605

10/55 Novoseek chemical compound relationships for CD55 gene (see all 55) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dafs	81.2	4	1700997 (1), 1712233 (1), 10906393 (1)
anaphylatoxin	52.8	1	9121154 (1)
rituximab	44.9	24	16367924 (4), 11520782 (4), 11719378 (2), 12697868 (2) (see all 10)
phosphatidylinositol	41.8	29	1702821 (2), 2182938 (1), 7691484 (1), 7527236 (1) (see all 13)
glycolipid	41.1	10	7687624 (2), 1691902 (1), 7615819 (1), 7527603 (1) (see all 7)
sucrose	12.9	8	19152664 (2), 12186694 (1), 1378912 (1), 10611479 (1) (see all 5)
atp	5.46	2	7510241 (1), 19154662 (1)
estrogen	5.31	6	8892654 (5)
dexamethasone	5.12	8	15009429 (4)
oligonucleotide	5	2	9648070 (1)

Search CenterWatch for drugs/clinical trials and news about CD55 / DAF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD55 gene (4 alternative transcripts):

NM_000574.3 NM_001114752.1 NM_001114543.1 NM_001114544.1

Unigene Cluster for CD55:

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

Hs.126517 [show with all ESTs]

Unigene Representative Sequence: NM_001114752

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367064(uc001hfr.4 uc001hfq.4 uc010psf.2 uc009xcf.3 uc009xce.3)

ENST00000367063 ENST00000391921 ENST00000488171 ENST00000314754 ENST00000482390

ENST00000343420 ENST00000465534 ENST00000476590 ENST00000367065 ENST00000391920

ENST00000367062 ENST00000367067

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD55 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD55
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CD55:
		hsa-miR-3658 hsa-miR-513a-3p hsa-miR-578 hsa-miR-138-2*
		SwitchGear 3'UTR luciferase reporter plasmid: CD55 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD55 (see all 7) OriGene shRNA RFP: CD55 OriGene siRNA: CD55
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD55

Additional cDNA sequence:

AB240566.1 AB240567.1 AB240568.1 AB240569.1 AB240570.1 AF052110.1 AK298549.1 AK300621.1

AK312448.1 AY055757.1 AY055758.1 AY055759.1 AY055760.1 BC001288.1 BT007159.1 M15799.1

M30142.1 M31516.1 U88576.1

24/32 DOTS entries (see all 32):

DT.454114 DT.98083655 DT.100827194 DT.80100435 DT.100827205 DT.100827202 DT.121461699 DT.75189288

DT.92456135 DT.99931303 DT.100827208 DT.121461669 DT.121461696 DT.100827193 DT.92456145 DT.121461683

DT.95363169 DT.97854983 DT.100827204 DT.121461679 DT.100809320 DT.100827192 DT.100827203 DT.100827207

24/520 AceView cDNA sequences (see all 520):

NM_000574 BM854824 BE349306 BE787245 AW628795 AU280745 BP381903 M30142

BQ008878 AU119089 N72946 AI591357 AI802973 CB216762 AW192059 CB135377

BU162711 BU153123 BQ420986 BQ228452 CA843618 AA678160 AA262303 BU191212

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CD55 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12
SP1:							-		-														-										-				-
SP2:																							-
SP3:																							-										-
SP4:							-		-						-								-
SP5:																							-

ECgene alternative splicing isoforms for CD55

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD55 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAACAAGA

About this image

CD55 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Kidney

Glomerulus

Kidney

Skeletal Muscle

Mandibular Arch Muscles

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

See CD55 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD55

SOURCE GeneReport for Unigene cluster: Hs.126517

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174

Tissue specificity: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma

complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and

variants of the molecule are present in body fluids and in extracellular matrix

SABiosciences Expression via Pathway-Focused PCR Array including CD55:

Angiogenic Growth Factors in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD55

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD55

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CD55 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	C4BPA⁶ CR1L⁶ (see all 5)	hypothetical protein LOC419853 (see all 5)	7(a) 20(a) (see all 5)	possible ortholog 1 ↔ many (see all 5)	26(2446262-2453125) 26(2469355-2475351)
lizard (Anolis carolinensis)	Reptilia	-- --	--	5(a) 17(a)	1 ↔ many 1 ↔ many	GL343228.1(2198166-2388531) GL344121.1(5744-32340)
zebrafish (Danio rerio)	Actinopterygii	CR759867.1⁶ CR352286.1⁶ (see all 5)	--	(see all 5)	possible ortholog possible ortholog (see all 5)	19(45630467-45650934) 19(45874989-46606132)
worm (Caenorhabditis elegans)	Secernentea	T07H6.4⁶	Protein T07H6.4	8(a)	possible ortholog	X(6281881-6286136)

ENSEMBL Gene Tree for CD55 (if available)
TreeFam Gene Tree for CD55 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD55 gene

CSMD1² SEZ6L2² SELP² C4BPA² CR2² SELL² CR1L² CSMD3²

SEZ6² SELE² SEZ6L² CSMD2² CR1² CD46² SVEP1²

9 SIMAP similar genes for CD55 using alignment to 8 protein entries: DAF_HUMAN (see all proteins):

DAF GLT8D2 LINC00596 C4BPA CR1L CR1

CR2 FAM175A SEZ6L

CD55 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174

Polymorphism: Responsible for the Cromer blood group system (CROM) [MIM:613793]. It consists of at least 8

high-incidence (Cr(a), Tc(a), Dr(a), Es(a), WES(b), UMC, IFC and GUTI) and three low-incidence (Tc(b), Tc(c) and

WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab there is reduced or absent expression of

DAF, respectively. In the case of the Dr(a-) phenotype, a single nucleotide substitution within exon 5 accounts for

two changes: a simple amino acid substitution, Leu-199 that is the basis of the antigenic variation, and an

alternative splicing event that underlies the decreased expression of DAF in this phenotype. The Inab phenotype is a

very rare one in which the red blood cells lack all Cromer system antigens. The red blood cells of individuals with

Inab phenotype have a deficiency of DAF, but these individuals are not known to have any associated hematologic or

other abnormalities

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34858744^1,2	C,	--	178189415(+)	`CACTAG/CATGGT`	2	--	us2k¹		2		NA WA	120
rs113859625^1,2		--	178189570(+)	`TAGGTA/GTGGGT`	2	--	us2k¹		2		CSA WA	120
rs1652334^1,2	H,	--	178189695(-)	`GTGGGG/AGTATT`	2	--	us2k¹		4		NS EA	370
rs12069746^1,2	C,H,	--	178189775(+)	`AAAAGG/TAATCT`	2	--	us2k¹ trp³		4		NS EA	372
rs34787256^1,2	C,	--	178189805(+)	`CAGACC/TCAGAT`	2	--	us2k¹		1		NA	2
rs17024952^1,2	C,F,H,	--	178189841(+)	`TGAGGC/TTATTC`	2	--	us2k¹		16		NA NS EA WA CSA	1430
rs2490258^1,2		--	178190229(-)	`gttttC/Ttggtc`	2	--	us2k¹		0	--	--	--	--
rs61822698^1,2	C	--	178190702(+)	`CGCGCG/ACGCAC`	2	--	us2k¹		1		WA	2
rs2564977^1,2	A	--	178190704(+)	`CGCGCA/GCACAC`	2	--	us2k¹		0	--	--	--	--
rs80283730^1,2		--	178190950(+)	`CCTCCC/TTAGTT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD55 (207494817 - 207534311 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD55: --
Human Gene Mutation Database (HGMD): CD55

Locus Specific Mutation Databases (LSDB): CD55
Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD55

DNA2.0 Custom Variant and Variant Library Synthesis for CD55

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD55 for disorders           About GeneDecksing

OMIM gene information: 125240    OMIM disorders: --

20/110 diseases for CD55 (see all 110):    About MalaCards

blood group cromer paroxysmal nocturnal hemoglobinuria autoimmune hemolytic anemia age related macular degeneration

pyoderma gangrenosum hemolytic anemia plasmodium falciparum malaria hemoglobinuria

non-hodgkin lymphoma hemorrhagic fever inflammatory bowel disease acute hemorrhagic conjunctivitis

macular degeneration pyoderma squamous cell carcinoma membranous glomerulonephritis

hemorrhagic fever with renal syndrome lupus erythematosus burkitt's lymphoma pancytopenia

5 diseases from the University of Copenhagen DISEASES database for CD55:

Anemia Proteinuria Bone marrow disease Cancer

Acute hemorrhagic conjunctivitis

10/95 Novoseek disease relationships for CD55 gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
paroxysmal hemoglobinuria nocturnal	91.9	37	19154662 (2), 1688570 (1), 9516159 (1), 1281489 (1) (see all 30)
hemolysis	66.3	27	9203959 (2), 1378912 (2), 11881969 (2), 7691484 (1) (see all 18)
anemia aplastic	59.5	4	7544152 (2), 7686037 (1), 11930678 (1)
hemoglobinuria	55.9	2	9844822 (1), 10539884 (1)
swine vesicular disease	48	1	15831949 (1)
anemia hemolytic	48	5	11930678 (1), 9892684 (1), 12213736 (1)
somatic mutations	41.4	2	18376800 (1), 7522635 (1)
anemia dyserythropoietic congenital	37.3	1	7506081 (1)
pancytopenia	36.6	1	15103939 (1)
enterovirus infections	33.9	1	15507656 (1)

Human Genome Epidemiology (HuGE) Navigator: CD55 (12 documents)

Export disorders for CD55 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD55 gene, integrated from 9 sources (see all 627):
(articles sorted by number of sources associating them with CD55)

Utopia: connect your pdf to the dynamic
world of online information

Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. (PubMed id 7519480)^{1, 2, 9} Lublin D.M.... Tanner M.J.A. (1994)
Complete determination of disulfide bonds localized within the short consensus repeat units of decay accelerating factor (CD55 antigen). (PubMed id 1377029)^{1, 2, 9} Nakano Y.... Tomita M. (1992)
Isolation of two forms of decay-accelerating factor (DAF) from human urine. (PubMed id 1712233)^{1, 2, 9} Nakano Y.... Tomita M. (1991)
Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol- anchored proteins released upon phospholipase D treatment. (PubMed id 16602701)^{1, 2} Elortza F.... Jensen O.N. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complement regulation at the molecular level: the structure of decay- accelerating factor. (PubMed id 14734808)^{1, 2} Lukacik P....Lea S.M. (2004)
GUTI: a new antigen in the Cromer blood group system. (PubMed id 12675719)^{1, 2} Storry J.R.... Reid M.E. (2003)
Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A. (PubMed id 12499389)^{1, 2} Williams P.... Lea S. (2003)
Solution structure of a functionally active fragment of decay- accelerating factor. (PubMed id 12672958)^{1, 2} Uhrinova S....Barlow P.N. (2003)
Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins. (PubMed id 14517339)^{1, 2} Elortza F....Jensen O.N. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1604	HGNC: 2665	AceView: DAF	Ensembl:ENSG00000196352	euGenes: HUgn1604
ECgene: CD55	Kegg: 1604	H-InvDB: CD55

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD55	Pharmacogenomics, SNPs, Pathways
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=cromer
CD55base	http://bioinf.uta.fi/CD55base/
Wikipedia	http://en.wikipedia.org/wiki/Decay_accelerating_factor
SeattleSNPs	http://pga.gs.washington.edu/data/daf/
Virus Particle ExploreR db	http://viperdb.scripps.edu/info_page.php?VDB=1upn

Intellectual Property for CD55 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD55 gene:
Search GeneIP for patents involving CD55

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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