Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD55 Gene

protein-coding   GIFtS: 65
GCID: GC01P207494

CD55 Molecule, Decay Accelerating Factor For Complement...

(Previous names: decay accelerating factor for complement (CD55, Cromer blood...)
(Previous symbol: DAF)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD55 Molecule, Decay Accelerating Factor For Complement (Cromer Blood
Group)1 2
     CROM2 5
DAF1 2 3 5     Decay Accelerating Factor For Complement (CD55, Cromer Blood Group System)1
CR2 3     TC2
CD55 Antigen2 3     Complement Decay-Accelerating Factor2

External Ids:    HGNC: 26651   Entrez Gene: 16042   Ensembl: ENSG000001963527   OMIM: 1252405   UniProtKB: P081743   

Export aliases for CD55 gene to outside databases

Previous GC identifers: GC01P205561 GC01P178191


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD55 Gene:
This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also
known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay,
disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute
the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been
identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma
component proteins but an alternatively spliced transcript produces a soluble protein present at much lower
levels. Additional, alternatively spliced transcript variants have been described, but their biological validity
has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD55 Gene: 
CD55 (CD55 molecule, decay accelerating factor for complement (Cromer blood group)) is a protein-coding gene. Diseases associated with CD55 include paroxysmal nocturnal hemoglobinuria, and cd59 deficiency, and among its related super-pathways are Immune response Lectin induced complement pathway and Classical Complement Pathway. GO annotations related to this gene include enzyme inhibitor activity. An important paralog of this gene is CSMD1.

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174
Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups
when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with
cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and
factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the
amplification convertases of the complement cascade

Gene Wiki entry for CD55 (Decay-accelerating factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD55 gene promoter:
         SRF   TBP   SRY   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD55 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD55

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD55


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32

CD55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD55 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207494:  view genomic region     (about GC identifiers)

Start:
207,494,817 bp from pter      End:
207,534,311 bp from pter
Size:
39,495 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174 (See protein sequence)
Recommended Name: Complement decay-accelerating factor precursor  
Size: 381 amino acids; 41400 Da
Subunit: Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Binds to coxsackievirus
A21, coxsackieviruses B1, B3 and B5, human enterovirus 70, human echoviruses 6, 7, 11, 12, 20 and 21 capsid
proteins and acts as a receptor for these viruses
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor
Subcellular location: Isoform 3: Secreted
Subcellular location: Isoform 4: Secreted
Subcellular location: Isoform 5: Secreted
Subcellular location: Isoform 6: Cell membrane; Lipid-anchor, GPI-anchor (Probable)
Subcellular location: Isoform 7: Cell membrane; Lipid-anchor, GPI-anchor (Probable)
6/21 PDB 3D structures from and Proteopedia for CD55 (see all 21):
1H03 (3D)        1H04 (3D)        1H2P (3D)        1H2Q (3D)        1M11 (3D)        1NWV (3D)    
Secondary accessions: B1AP14 D3DT83 D3DT84 E7ER69 P09679 P78361 Q14UF2 Q14UF3 Q14UF4 Q14UF5
Q14UF6
Alternative splicing: 7 isoforms:  P08174-1   P08174-2   P08174-3   P08174-4   P08174-5   P08174-6   P08174-7   (Includes full sequence of the intron 7)

Explore the universe of human proteins at neXtProt for CD55: NX_P08174

Explore proteomics data for CD55 at MOPED 

Post-translational modifications:

  • UniProtKB: The Ser/Thr-rich domain is heavily O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08174

  • CD55 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD55 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000565.1  NP_001108224.1  

    ENSEMBL proteins: 
     ENSP00000356031   ENSP00000356030   ENSP00000375788   ENSP00000316333   ENSP00000433984  
     ENSP00000340631   ENSP00000356032   ENSP00000375787   ENSP00000356029   ENSP00000356034  
    Reactome Protein details: P08174
    Human Recombinant Protein Products for CD55: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD55 (CD55/DAF)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CD55
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CD55
    GenScript Custom Purified and Recombinant Proteins Services for CD55
    Novus Biologicals CD55 Proteins
    Novus Biologicals CD55 Lysates
    Sino Biological Recombinant Protein for CD55
    Sino Biological Cell Lysate for CD55 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS2433596
    GO:0009986cell surface IDA15907827
    GO:0016324apical plasma membrane IEA--

    CD55 for ontologies           About GeneDecksing



    CD55 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD55
    R&D Systems Antibodies for CD55 (CD55/DAF)
    OriGene Antibodies for CD55
    OriGene Custom Antibody Services for CD55
    GenScript Custom Superior Antibodies Services for CD55
    Novus Biologicals CD55 Antibodies
    Abcam antibodies for CD55
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CD55
    LSBio Antibodies in human, mouse, rat for CD55 

    Assay Products for CD55: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD55
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD55
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    bloodgroup: Blood group antigens

    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry P08174

    ProtoNet protein and cluster: P08174

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: DAF_HUMAN, P08174
    Domain: The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation
    for the active site on SCR3 (By similarity)
    Similarity: Belongs to the receptors of complement activation (RCA) family
    Similarity: Contains 4 Sushi (CCP/SCR) domains


    CD55 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAF_HUMAN, P08174
    Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups
    when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with
    cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and
    factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the
    amplification convertases of the complement cascade

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0004857enzyme inhibitor activity IEA--
         
    CD55 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd55):
     behavior/neurological  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  renal/urinary system 

    CD55 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD55: Cd55tm1Mme Cd55tm1Song

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD55 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD55

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD55 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD55 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD55
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CD55:
    hsa-miR-3658 hsa-miR-513a-3p hsa-miR-578 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCD55 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD55
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD55

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD55
    Sirion Biotech Customized adenovirus for overexpression of CD55

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD55 (see all 14)
    OriGene ORF clones in mouse, rat for CD55
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD55 (NM_000574)
    Sino Biological Human cDNA Clone for CD55
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD55
    Sirion Biotech Customized lentivirus for stable overexpression of CD55 
                         Customized lentivirus expression plasmids for stable overexpression of CD55 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD55
    Search LifeMap BioReagents cell lines for CD55
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD55


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD55 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Lectin induced complement pathway0.56
    Immune response Classic complement pathway0.53
    Immune response Alternative complement pathway0.56
    Immune response Classical complement pathway0.52
    Immune response Lectin Induced complement pathway0.56
    Regulation of Complement cascade0.50
    2Classical Complement Pathway
    Complement Activation, Classical Pathway0.68
    Complement Activation Pathways0.31
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    5Classical antibody-mediated complement activation
    Complement cascade0.76

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CD55
        Immune response Alternative complement pathway
    Immune response Classic complement pathway
    Immune response Lectin Induced complement pathway


    3 GeneGo (Thomson Reuters) Pathways for CD55
        Immune response Alternative complement pathway
    Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    1 BioSystems Pathway for CD55
        Complement Activation, Classical Pathway

    1 Sino Biological Pathway for CD55 
        Complement Activation Pathways

    5/8        Reactome Pathways for CD55 (see all 8)
        Signaling by GPCR
    GPCR ligand binding
    Signal Transduction
    Regulation of Complement cascade
    Innate Immune System


    3         Kegg Pathways  (Kegg details for CD55):
        Complement and coagulation cascades
    Hematopoietic cell lineage
    Viral myocarditis


    CD55 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD55

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for CD55 (P081743 ENSP000003163334) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD97P489603, ENSP000002427864I2D: score=2 STRING: ENSP00000242786
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    LCKP062393, ENSP000003378254I2D: score=2 STRING: ENSP00000337825
    CD14P085713, ENSP000003042364I2D: score=2 STRING: ENSP00000304236
    CR1P179273, ENSP000003560164I2D: score=2 STRING: ENSP00000356016
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006958complement activation, classical pathway IEA--
    GO:0007204elevation of cytosolic calcium ion concentration IDA8223854
    GO:0007283spermatogenesis IEA--
    GO:0030449regulation of complement activation TAS--
    GO:0043086negative regulation of catalytic activity ----

    CD55 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD55 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD55 (DAF)

    1 DrugBank Compound for CD55    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ChloramphenicolCAF (see all 7)56-75-7targetother17376081 15331605

    10/55 Novoseek inferred chemical compound relationships for CD55 gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dafs 81.2 4 1700997 (1), 1712233 (1), 10906393 (1)
    anaphylatoxin 52.8 1 9121154 (1)
    rituximab 44.9 24 16367924 (4), 11520782 (4), 11719378 (2), 12697868 (2) (see all 10)
    phosphatidylinositol 41.8 29 1702821 (2), 2182938 (1), 7691484 (1), 7527236 (1) (see all 13)
    glycolipid 41.1 10 7687624 (2), 1691902 (1), 7615819 (1), 7527603 (1) (see all 7)
    sucrose 12.9 8 19152664 (2), 12186694 (1), 1378912 (1), 10611479 (1) (see all 5)
    atp 5.46 2 7510241 (1), 19154662 (1)
    estrogen 5.31 6 8892654 (5)
    dexamethasone 5.12 8 15009429 (4)
    oligonucleotide 5 2 9648070 (1)

    Search CenterWatch for drugs/clinical trials and news about CD55 / DAF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD55 gene (4 alternative transcripts): 
    NM_000574.3  NM_001114752.1  NM_001114543.1  NM_001114544.1  

    Unigene Cluster for CD55:

    CD55 molecule, decay accelerating factor for complement (Cromer blood group)
    Hs.126517  [show with all ESTs]
    Unigene Representative Sequence: NM_001114752
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367064(uc001hfr.4 uc001hfq.4 uc010psf.2 uc009xcf.3 uc009xce.3)
    ENST00000367063 ENST00000391921 ENST00000488171 ENST00000314754 ENST00000482390
    ENST00000343420 ENST00000465534 ENST00000476590 ENST00000367065 ENST00000391920
    ENST00000367062 ENST00000367067
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD55
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CD55:
    hsa-miR-3658 hsa-miR-513a-3p hsa-miR-578 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCD55 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD55
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD55
    Clone
    Products:
         
    OriGene clones in human, mouse for CD55 (see all 14)
    OriGene ORF clones in mouse, rat for CD55
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD55 (NM_000574)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD55
    Sirion Biotech Customized lentivirus for stable overexpression of CD55 
                         Customized lentivirus expression plasmids for stable overexpression of CD55 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD55
    OriGene qSTAR qPCR primer pairs in human, mouse for CD55
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD55
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD55
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD55

    Additional mRNA sequence: 

    AB240566.1 AB240567.1 AB240568.1 AB240569.1 AB240570.1 AF052110.1 AK298549.1 AK300621.1 
    AK312448.1 AY055757.1 AY055758.1 AY055759.1 AY055760.1 BC001288.1 BT007159.1 M15799.1 
    M30142.1 M31516.1 U88576.1 

    24/32 DOTS entries (see all 32):

    DT.454114  DT.98083655  DT.100827194  DT.80100435  DT.100827205  DT.100827202  DT.121461699  DT.75189288 
    DT.92456135  DT.99931303  DT.100827208  DT.121461669  DT.121461696  DT.100827193  DT.92456145  DT.121461683 
    DT.97854983  DT.100827204  DT.121461679  DT.95363169  DT.100809320  DT.100827192  DT.100827203  DT.121461660 

    24/520 AceView cDNA sequences (see all 520):

    AL542661 BQ015060 CB853106 BQ086234 BT007159 BP337991 CR613044 BQ230137 
    BQ574176 AL047490 CR596647 BU754081 AW674554 CB135371 BM818848 H71561 
    F02937 BQ051318 BM806293 CR623902 BM819845 CR603699 BU689602 BU164595 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CD55 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                    -     -                                         -                             -           -                     
    SP2:                                                                    -                                                               
    SP3:                                                                    -                             -                                 
    SP4:                    -     -                 -                       -                                                               
    SP5:                                                                    -                                                               


    ECgene alternative splicing isoforms for CD55

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD55 expression in normal human tissues (normalized intensities)      CD55 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAACAAGA
    CD55 Expression
    About this image


    CD55 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             ovary ; follicle cells   
     
     Adrenal Gland (Endocrine System)    fully expand to see all 2 entries
             adrenal gland ; glandular cells   
             Adrenal Cortex   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Stromal Cells Subcutaneous White Adipose
             Body Subcutaneous White Adipose
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Umbilical cord blood-derived endothelial progenitor cells
             Human Choroid Plexus Endothelial Cells (HCPEC)   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus

    See CD55 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD55

    SOURCE GeneReport for Unigene cluster: Hs.126517

    UniProtKB/Swiss-Prot: DAF_HUMAN, P08174
    Tissue specificity: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma
    complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and
    variants of the molecule are present in body fluids and in extracellular matrix

        SABiosciences Expression via Pathway-Focused PCR Array including CD55: 
              Angiogenic Growth Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD55
    OriGene qSTAR qPCR primer pairs in human, mouse for CD55
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CD55
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD55
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD55
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD55

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CD55 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd555 CD55 antigen   --   1 (56.89 cM) 130439027 
    zebrafish
    (Danio rerio)
    Actinopterygii CD556
    CD55 molecule, decay accelerating factor for compl...
    17(a)
    1 ↔ 1
    6(47424408-47446839)
    fruit fly
    (Drosophila melanogaster)
    Insecta hig6
    CG101866
    --
    6(a)
    4(a)
    possible ortholog
    1 ↔ 1
    2R(5115286-5134752)
    2L(19508953-19517201)
    worm
    (Caenorhabditis elegans)
    Secernentea lev-96
    T07H6.46
    Protein T07H6.4
    9(a)
    6(a)
    1 ↔ 1
    possible ortholog
    X(6286453-6291732)
    X(6281917-6286172)


    ENSEMBL Gene Tree for CD55 (if available)
    TreeFam Gene Tree for CD55 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD55 gene
    CSMD12  CFHR52  CFHR42  F13B2  CFHR22  CD462  SELP2  C4BPA2  
    CR22  CFH2  CSMD32  CR1L2  APOH2  SELE2  CSMD22  CFHR32  
    CR12  CFHR12  
    8 SIMAP similar genes for CD55 using alignment to 8 protein entries:     DAF_HUMAN (see all proteins):
    DAF    GLT8D2    LINC00596    C4BPA    CR1L    CR1
    CR2    FAM175A

    CD55 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: DAF_HUMAN, P08174
    Polymorphism: Responsible for the Cromer blood group system (CROM) [MIM:613793]. It consists of at least 8
    high-incidence (Cr(a), Tc(a), Dr(a), Es(a), WES(b), UMC, IFC and GUTI) and three low-incidence (Tc(b), Tc(c) and
    WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab there is reduced or absent
    expression of DAF, respectively. In the case of the Dr(a-) phenotype, a single nucleotide substitution within
    exon 5 accounts for two changes: a simple amino acid substitution, Leu-199 that is the basis of the antigenic
    variation, and an alternative splicing event that underlies the decreased expression of DAF in this phenotype.
    The Inab phenotype is a very rare one in which the red blood cells lack all Cromer system antigens. The red blood
    cells of individuals with Inab phenotype have a deficiency of DAF, but these individuals are not known to have
    any associated hematologic or other abnormalities


    10/19768 SNPs in CD55 are shown (see all 19768)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0158844
    ----see VAR_0158842 R H mis40--------
    rs352095551,2
    C--178209045(+) AAGTT-/A/A   
       A
    /TAA
    AATGT
    4 -- int1 cds10--------
    rs596068831,2
    C--207498680(+) ATCTC-/AAAAAA 2 -- int10--------
    rs2010178351,2
    C--207503675(+) AAAAA-/AGGACA 2 -- int10--------
    rs57803841,2
    C--207504820(+) TGTAT-/ACACACA 2 -- int10--------
    rs556905591,2
    C--207511004(+) AAAAA-/ATTCTG 2 -- int10--------
    rs599769291,2
    C--207512581(+) TTAATAAT/-GTGTA 2 -- cds11Minor allele frequency- -:0.00NA 2
    rs758838471,2
    C--207516325(+) TGTCAA/GTGTAT 2 -- int11Minor allele frequency- G:0.01WA 118
    rs1119817321,2
    C--207522129(+) TCTGCG/ATATGG 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1139036451,2
    C,F--207523539(+) CTTGCT/ATCCCA 2 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for CD55 (207494817 - 207534311 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CD55:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722084CNV Deletion23290073
    nsv873132CNV Loss21882294
    nsv508688CNV Loss20534489
    nsv4221CNV Loss18451855
    dgv523n71CNV Loss21882294
    nsv873131CNV Gain21882294


    Human Gene Mutation Database (HGMD): CD55

    Locus Specific Mutation Databases (LSDB): CD55
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD55
    DNA2.0 Custom Variant and Variant Library Synthesis for CD55

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 125240    OMIM disorders: --

    20/108 diseases for CD55 (see all 108):    About MalaCards
    paroxysmal nocturnal hemoglobinuria    cd59 deficiency    hemoglobinuria    acute hemorrhagic conjunctivitis
    autoimmune hemolytic anemia    pancytopenia    hemolytic anemia    pyoderma gangrenosum
    proliferative glomerulonephritis    pyoderma    measles    membranous glomerulonephritis
    hemorrhagic fever with renal syndrome    lymphopenia    vesiculitis    glomerulonephritis
    meningitis    pyelonephritis    bacterial meningitis    thymoma

    5 diseases from the University of Copenhagen DISEASES database for CD55:
    Anemia     Proteinuria     Bone marrow disease     Cancer
    Acute hemorrhagic conjunctivitis

    CD55 for disorders           About GeneDecksing

    10/95 Novoseek inferred disease relationships for CD55 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paroxysmal hemoglobinuria nocturnal 91.9 37 19154662 (2), 1688570 (1), 9516159 (1), 1281489 (1) (see all 30)
    hemolysis 66.3 27 9203959 (2), 1378912 (2), 11881969 (2), 7691484 (1) (see all 18)
    anemia aplastic 59.5 4 7544152 (2), 7686037 (1), 11930678 (1)
    hemoglobinuria 55.9 2 9844822 (1), 10539884 (1)
    swine vesicular disease 48 1 15831949 (1)
    anemia hemolytic 48 5 11930678 (1), 9892684 (1), 12213736 (1)
    somatic mutations 41.4 2 18376800 (1), 7522635 (1)
    anemia dyserythropoietic congenital 37.3 1 7506081 (1)
    pancytopenia 36.6 1 15103939 (1)
    enterovirus infections 33.9 1 15507656 (1)

    Genetic Association Database (GAD): CD55
    Human Genome Epidemiology (HuGE) Navigator: CD55 (12 documents)

    Export disorders for CD55 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD55 gene, integrated from 9 sources (see all 635):
    (articles sorted by number of sources associating them with CD55)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. (PubMed id 7519480)1, 2, 9 Lublin D.M.... Tanner M.J.A. (1994)
    2. Complete determination of disulfide bonds localized within the short consensus repeat units of decay accelerating factor (CD55 antigen). (PubMed id 1377029)1, 2, 9 Nakano Y.... Tomita M. (1992)
    3. Isolation of two forms of decay-accelerating factor (DAF) from human urine. (PubMed id 1712233)1, 2, 9 Nakano Y.... Tomita M. (1991)
    4. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    5. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    6. Identification of fetal and maternal single nucleotid e polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (2010)
    7. A genetic association study of maternal and fetal can didate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (2010)
    8. Associations between decay-accelerating factor polymo rphisms and allergic respiratory diseases. (PubMed id 19681921)1, 4 Kawai T....Noguchi E. (2009)
    9. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (2009)
    10. Investigation of CBS, MTR, RFC-1 and TC polymorphisms as maternal risk factors for Down syndrome. (PubMed id 19729796)1, 4 Fintelman-Rodrigues N....Santos-RebouAsas C.B. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1604 HGNC: 2665 AceView: DAF Ensembl:ENSG00000196352 euGenes: HUgn1604
    ECgene: CD55 Kegg: 1604 H-InvDB: CD55

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD55 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=cromer
    CD55basehttp://bioinf.uta.fi/CD55base/
    Wikipedia http://en.wikipedia.org/wiki/Decay_accelerating_factor
    SeattleSNPshttp://pga.gs.washington.edu/data/daf/
    Virus Particle ExploreR dbhttp://viperdb.scripps.edu/info_page.php?VDB=1upn

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD55 gene:
    Search GeneIP for patents involving CD55

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CD55
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CD55 (CD55/DAF)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CD55 (CD55/DAF)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CD55   OriGene RNAi products in human, mouse, rat for CD55  
     OriGene qPCR primer pairs and template standards for CD55   OriGene Protein Over-expression Lysate for CD55  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CD55  
     OriGene qSTAR qPCR primer pairs in human, mouse for CD55   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CD55   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD55   OriGene Custom Protein Services for CD55  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD55
     QIAGEN SeqTarget long-range PCR primers for resequencing CD55
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD55
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD55
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD55
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD55
     GenScript Custom Purified and Recombinant Proteins Services for CD55 GenScript cDNA clones with any tag delivered in your preferred vector for CD55
     GenScript Custom Assay Services for CD55 GenScript Custom Superior Antibodies Services for CD55
     GenScript Custom overexpressing Cell Line Services for CD55 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CD55 promoter
     Search Chromatin IP Primers for CD55
     RT2 qPCR Primer Assay in human, mouse / rat CD55
     GNC Network for CD55
     SABiosciences PCR Arrays including human, mouse, rat CD55
     Search Tocris compounds for CD55 (DAF)
     Proteins and Antibodies for CD55
     Cell Lysates for CD55
     cDNA Clones for CD55
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CD55 antibodies
     CD55 proteins
     CD55 lysates
     Antibodies for CD55
     See all of Abcam's Antibodies, Kits and Proteins for CD55
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CD55
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD55
     SwitchGear 3'UTR luciferase reporter plasmids for CD55
     SwitchGear Promoter luciferase reporter plasmids for CD55
     ThermoFisher Antibodies for CD55
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD55
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CD55
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD55
    Customized:
     lentivirus for stable overexpression of CD55
     lentivirus expression plasmids for stable overexpression of CD55
     adenovirus for overexpression of CD55
     LSBio Antibodies in human, mouse, rat for CD55
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CD55 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4