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CD55 Gene

protein-coding   GIFtS: 66
GCID: GC01P207494

CD55 Molecule, Decay Accelerating Factor For Complement...

(Previous names: decay accelerating factor for complement (CD55, Cromer blood...)
(Previous symbol: DAF)
  See CD55-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD55 Molecule, Decay Accelerating Factor For Complement (Cromer Blood
Group)1 2
     CROM2 5
DAF1 2 3 5     Decay Accelerating Factor For Complement (CD55, Cromer Blood Group System)1
CR2 3     TC2
CD55 Antigen2 3     Complement Decay-Accelerating Factor2

External Ids:    HGNC: 26651   Entrez Gene: 16042   Ensembl: ENSG000001963527   OMIM: 1252405   UniProtKB: P081743   

Export aliases for CD55 gene to outside databases

Previous GC identifers: GC01P205561 GC01P178191


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD55 Gene:
This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also
known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay,
disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute
the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been
identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma
component proteins but an alternatively spliced transcript produces a soluble protein present at much lower
levels. Additional, alternatively spliced transcript variants have been described, but their biological validity
has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD55 Gene:
CD55 (CD55 molecule, decay accelerating factor for complement (Cromer blood group)) is a protein-coding gene. Diseases associated with CD55 include acute hemorrhagic conjunctivitis, and hemoglobinuria. GO annotations related to this gene include enzyme inhibitor activity and virus receptor activity. An important paralog of this gene is CSMD1.

UniProtKB/Swiss-Prot: DAF_HUMAN, P08174
Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups
when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with
cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and
factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the
amplification convertases of the complement cascade

Gene Wiki entry for CD55 (Decay-accelerating factor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD55 gene promoter:
         SRF   TBP   SRY   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD55 promoter sequence
   Search Chromatin IP Primers for CD55

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD55


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32

CD55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD55 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207494:  view genomic region     (about GC identifiers)

Start:
207,494,817 bp from pter      End:
207,534,311 bp from pter
Size:
39,495 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DAF_HUMAN, P08174 (See protein sequence)
Recommended Name: Complement decay-accelerating factor precursor  
Size: 381 amino acids; 41400 Da
Subunit: Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Binds to coxsackievirus
A21, coxsackieviruses B1, B3 and B5, human enterovirus 70, human echoviruses 6, 7, 11, 12, 20 and 21 capsid
proteins and acts as a receptor for these viruses
Selected PDB 3D structures from and Proteopedia for CD55 (see all 21):
1H03 (3D)        1H04 (3D)        1H2P (3D)        1H2Q (3D)        1M11 (3D)        1NWV (3D)    
Secondary accessions: B1AP14 D3DT83 D3DT84 E7ER69 P09679 P78361 Q14UF2 Q14UF3 Q14UF4 Q14UF5
Q14UF6
Alternative splicing: 7 isoforms:  P08174-1   P08174-2   P08174-3   P08174-4   P08174-5   P08174-6   P08174-7   (Includes full sequence of the intron 7)

Explore the universe of human proteins at neXtProt for CD55: NX_P08174

Explore proteomics data for CD55 at MOPED

Post-translational modifications: 

  • The Ser/Thr-rich domain is heavily O-glycosylated1
  • Glycosylation2 at Asn95, Thr343, Thr344
  • Modification sites at PhosphoSitePlus

  • See CD55 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000565.1  NP_001108224.1  

    ENSEMBL proteins: 
     ENSP00000356031   ENSP00000356030   ENSP00000375788   ENSP00000316333   ENSP00000433984  
     ENSP00000340631   ENSP00000356032   ENSP00000375787   ENSP00000356029   ENSP00000356034  
    Reactome Protein details: P08174

    CD55 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD55 (CD55/DAF)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD55
    OriGene Protein Over-expression Lysate for CD55
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CD55
    GenScript Custom Purified and Recombinant Proteins Services for CD55
    Novus Biologicals CD55 Proteins
    Novus Biologicals CD55 Lysates
    Sino Biological Recombinant Protein for CD55
    Sino Biological Cell Lysate for CD55
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD55 

    CD55 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD55
    R&D Systems Antibodies for CD55 (CD55/DAF)
    OriGene Antibodies for CD55
    OriGene Custom Antibody Services for CD55
    Novus Biologicals CD55 Antibodies
    Abcam antibodies for CD55
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CD55
    LSBio Antibodies in human, mouse, rat for CD55

    CD55 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD55
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD55
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CD55 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    bloodgroup: Blood group antigens

    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry P08174

    ProtoNet protein and cluster: P08174

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: DAF_HUMAN, P08174
    Domain: The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation
    for the active site on SCR3 (By similarity)
    Similarity: Belongs to the receptors of complement activation (RCA) family
    Similarity: Contains 4 Sushi (CCP/SCR) domains


    Find genes that share domains with CD55           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAF_HUMAN, P08174
    Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups
    when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with
    cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and
    factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the
    amplification convertases of the complement cascade

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IDA7525274
    GO:0004857enzyme inhibitor activity IEA--
    GO:0005515protein binding IPI9064337
    GO:0008289lipid binding IDA12731067
         
    Find genes that share ontologies with CD55           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd55):
     behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  renal/urinary system 

    Find genes that share phenotypes with CD55           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD55: Cd55tm1Mme Cd55tm1Song

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD55
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD55

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD55
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD55

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD55:
    hsa-mir-16-5p (MIRT031474), hsa-mir-132-3p (MIRT021757), hsa-mir-124-3p (MIRT022237), hsa-let-7a-5p (MIRT052481)

    Block miRNA regulation of human, mouse, rat CD55 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CD55:
    hsa-miR-3658 hsa-miR-513a-3p hsa-miR-578 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCD55 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD55
    Predesigned siRNA for gene silencing in human, mouse, rat CD55

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD55

    Clone
    Products:
         
    OriGene clones in human, mouse for CD55 (see all 12)
    OriGene ORF clones in mouse, rat for CD55
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD55 (NM_000574)
    Sino Biological Human cDNA Clone for CD55
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD55

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD55
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD55 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD55


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAF_HUMAN, P08174: Isoform 1: Cell membrane; Single-pass type I membrane protein
    DAF_HUMAN, P08174: Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor
    DAF_HUMAN, P08174: Isoform 3: Secreted
    DAF_HUMAN, P08174: Isoform 4: Secreted
    DAF_HUMAN, P08174: Isoform 5: Secreted
    DAF_HUMAN, P08174: Isoform 6: Cell membrane; Lipid-anchor, GPI-anchor (Probable)
    DAF_HUMAN, P08174: Isoform 7: Cell membrane; Lipid-anchor, GPI-anchor (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    nucleus2
    cytoskeleton1
    endosome1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2433596
    GO:0009986cell surface IDA15907827
    GO:0016324apical plasma membrane IEA--

    Find genes that share ontologies with CD55           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD55 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Complement Pathway
    Immune response Lectin Induced complement pathway0.56
    Regulation of Complement cascade0.48
    Immune response Classic complement pathway0.56
    Complement Activation Pathways0.30
    Immune response Alternative complement pathway0.56
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement Activation, Classical Pathway0.00
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    4Peptide ligand-binding receptors
    GPCR ligand binding0.71
    5Creation of C4 and C2 activators
    Complement cascade0.68


    Find genes that share SuperPaths with CD55           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CD55
        14-3-3 Induced Intracellular Signaling

    3 GeneGo (Thomson Reuters) Pathways for CD55
        Immune response Alternative complement pathway
    Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    1 BioSystems Pathway for CD55
        Complement Activation, Classical Pathway

    1 Sino Biological Pathway for CD55
        Complement Activation Pathways

    2 Reactome Pathways for CD55
        Regulation of Complement cascade
    Class B/2 (Secretin family receptors)


    3 Kegg Pathways  (Kegg details for CD55):
        Complement and coagulation cascades
    Hematopoietic cell lineage
    Viral myocarditis

        Pathway & Disease-focused RT2 Profiler PCR Array including CD55: 
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD55

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for CD55 (P081743 ENSP000003163334) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD97P489603, ENSP000002427864I2D: score=2 STRING: ENSP00000242786
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    LCKP062393, ENSP000003378254I2D: score=2 STRING: ENSP00000337825
    CD14P085713, ENSP000003042364I2D: score=2 STRING: ENSP00000304236
    CR1P179273, ENSP000003560164I2D: score=2 STRING: ENSP00000356016
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006958complement activation, classical pathway IEA--
    GO:0007204positive regulation of cytosolic calcium ion concentration IDA8223854
    GO:0007283spermatogenesis IEA--
    GO:0009615response to virus IDA7525274
    GO:0030449regulation of complement activation TAS--

    Find genes that share ontologies with CD55           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD55 (DAF)

    1 DrugBank Compound for CD55    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ChloramphenicolCAF (see all 7)56-75-7targetother17376081 15331605

    Selected Novoseek inferred chemical compound relationships for CD55 gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dafs 81.2 4 1700997 (1), 1712233 (1), 10906393 (1)
    anaphylatoxin 52.8 1 9121154 (1)
    rituximab 44.9 24 16367924 (4), 11520782 (4), 11719378 (2), 12697868 (2) (see all 10)
    phosphatidylinositol 41.8 29 1702821 (2), 2182938 (1), 7691484 (1), 7527236 (1) (see all 13)
    glycolipid 41.1 10 7687624 (2), 1691902 (1), 7615819 (1), 7527603 (1) (see all 7)
    sucrose 12.9 8 19152664 (2), 12186694 (1), 1378912 (1), 10611479 (1) (see all 5)
    atp 5.46 2 7510241 (1), 19154662 (1)
    estrogen 5.31 6 8892654 (5)
    dexamethasone 5.12 8 15009429 (4)
    oligonucleotide 5 2 9648070 (1)



    Find genes that share compounds with CD55           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD55 gene (4 alternative transcripts): 
    NM_000574.3  NM_001114752.1  NM_001114543.1  NM_001114544.1  

    Unigene Cluster for CD55:

    CD55 molecule, decay accelerating factor for complement (Cromer blood group)
    Hs.126517  [show with all ESTs]
    Unigene Representative Sequence: NM_001114752
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367064(uc001hfr.4 uc001hfq.4 uc010psf.2 uc009xcf.3 uc009xce.3)
    ENST00000367063 ENST00000391921 ENST00000488171 ENST00000314754 ENST00000482390
    ENST00000343420 ENST00000465534 ENST00000476590 ENST00000367065 ENST00000391920
    ENST00000367062 ENST00000367067
    miRNA
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    Block miRNA regulation of human, mouse, rat CD55 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CD55:
    hsa-miR-3658 hsa-miR-513a-3p hsa-miR-578 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCD55 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CD55
    Predesigned siRNA for gene silencing in human, mouse, rat CD55
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD55 (NM_000574)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD55
    Primer
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    OriGene qPCR primer pairs and template standards for CD55
    OriGene qSTAR qPCR primer pairs in human, mouse for CD55
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CD55
      QuantiTect SYBR Green Assays in human, mouse, rat CD55
      QuantiFast Probe-based Assays in human, mouse, rat CD55

    Additional mRNA sequence: 

    AB240566.1 AB240567.1 AB240568.1 AB240569.1 AB240570.1 AF052110.1 AK298549.1 AK300621.1 
    AK312448.1 AY055757.1 AY055758.1 AY055759.1 AY055760.1 BC001288.1 BT007159.1 M15799.1 
    M30142.1 M31516.1 U88576.1 

    Selected DOTS entries (see all 32):

    DT.454114  DT.98083655  DT.100827194  DT.80100435  DT.100827205  DT.100827202  DT.121461699  DT.75189288 
    DT.92456135  DT.99931303  DT.100827208  DT.121461669  DT.121461696  DT.100827193  DT.92456145  DT.121461683 
    DT.97854983  DT.100827204  DT.121461679  DT.95363169  DT.100809320  DT.100827192  DT.100827203  DT.121461660 

    Selected AceView cDNA sequences (see all 520):

    AI888485 CA748776 BP365936 CK822926 AF052110 BF665958 CB217037 H56567 
    CR596368 BP353891 BP353106 BQ221490 BQ233015 CR624858 CA843365 BC001288 
    BQ231176 AV703570 AL550277 BQ221579 BE049467 H16044 NM_000574 BM854824 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD55 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                    -     -                                         -                             -           -                     
    SP2:                                                                    -                                                               
    SP3:                                                                    -                             -                                 
    SP4:                    -     -                 -                       -                                                               
    SP5:                                                                    -                                                               


    ECgene alternative splicing isoforms for CD55

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CD55 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAACAAGA
    CD55 Expression
    About this image


    CD55 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Stromal Cells Subcutaneous White Adipose
             Body Subcutaneous White Adipose
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical Arteries
             Umbilical cord blood-derived endothelial progenitor cells
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
    CD55 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD55 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126517

    UniProtKB/Swiss-Prot: DAF_HUMAN, P08174
    Tissue specificity: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma
    complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and
    variants of the molecule are present in body fluids and in extracellular matrix

        Pathway & Disease-focused RT2 Profiler PCR Array including CD55: 
              Angiogenic Growth Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD55 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd551 , 5 CD55 antigen1, 5 62.35(n)1
    50(a)1
      1 (56.89 cM)5
    131361  NM_010016.21  NP_034146.21 
     1304390275 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    18(a)
    many ↔ many
    26(2614391-2618174)
    zebrafish
    (Danio rerio)
    Actinopterygii rca2.16
    rca2.26
    regulator of complement activation group 2 gene 2
    22(a)
    21(a)
    many ↔ many
    many ↔ many
    23(26381820-26407620) ENSDARG00000056075
    23(26413284-26415932) ENSDARG00000095512


    ENSEMBL Gene Tree for CD55 (if available)
    TreeFam Gene Tree for CD55 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD55 gene
    CSMD12  SELP2  C4BPA2  CR22  SELL2  CSMD32  CR1L2  APOH2  
    SELE2  CSMD22  CD462  CR12  SVEP12  
    8 SIMAP similar genes for CD55 using alignment to 8 protein entries:     DAF_HUMAN (see all proteins):
    DAF    GLT8D2    LINC00596    C4BPA    CR1L    CR1
    CR2    FAM175A

    Find genes that share paralogs with CD55           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    DAF_HUMAN, P08174: Responsible for the Cromer blood group system (CROM) [MIM:613793]. It consists of at least 8
    high-incidence (Cr(a), Tc(a), Dr(a), Es(a), WES(b), UMC, IFC and GUTI) and three low-incidence (Tc(b), Tc(c) and
    WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab there is reduced or absent
    expression of DAF, respectively. In the case of the Dr(a-) phenotype, a single nucleotide substitution within
    exon 5 accounts for two changes: a simple amino acid substitution, Leu-199 that is the basis of the antigenic
    variation, and an alternative splicing event that underlies the decreased expression of DAF in this phenotype.
    The Inab phenotype is a very rare one in which the red blood cells lack all Cromer system antigens. The red blood
    cells of individuals with Inab phenotype have a deficiency of DAF, but these individuals are not known to have
    any associated hematologic or other abnormalities


    Selected SNPs for CD55 (see all 19768)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352095551,2
    C--178209045(+) AAGTT-/A/A   
       A
    /TAA
    AATGT
    4 -- int1 cds10--------
    rs596068831,2
    C--207498680(+) ATCTC-/AAAAAA 2 -- int10--------
    rs2010178351,2
    C--207503675(+) AAAAA-/AGGACA 2 -- int10--------
    rs57803841,2
    C--207504820(+) TGTAT-/ACACACA 2 -- int10--------
    rs556905591,2
    C--207511004(+) AAAAA-/ATTCTG 2 -- int10--------
    rs599769291,2
    C--207512581(+) TTAATAAT/-GTGTA 2 -- cds11Minor allele frequency- -:0.00NA 2
    rs758838471,2
    C--207516325(+) TGTCAA/GTGTAT 2 -- int11Minor allele frequency- G:0.01WA 118
    rs1119817321,2
    C--207522129(+) TCTGCG/ATATGG 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1139036451,2
    C,F--207523539(+) CTTGCT/ATCCCA 2 -- int11Minor allele frequency- A:0.50WA 2
    rs287390121,2
    C,F--207524192(+) TTTTAT/CTCAGT 2 -- int13Minor allele frequency- C:0.02NS CSA 96

    HapMap Linkage Disequilibrium report for CD55 (207494817 - 207534311 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CD55:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722084CNV Deletion23290073
    nsv873132CNV Loss21882294
    nsv508688CNV Loss20534489
    nsv4221CNV Loss18451855
    dgv523n71CNV Loss21882294
    nsv873131CNV Gain21882294

    Human Gene Mutation Database (HGMD): CD55
    Locus Specific Mutation Databases (LSDB): CD55

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD55
    DNA2.0 Custom Variant and Variant Library Synthesis for CD55

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 125240   
    OMIM disorders: 613793  
    5 diseases for CD55:    
    About MalaCards
    acute hemorrhagic conjunctivitis    hemoglobinuria    autoimmune hemolytic anemia    paroxysmal nocturnal hemoglobinuria
    malaria

    5 diseases from the University of Copenhagen DISEASES database for CD55:
    Anemia     Proteinuria     Bone marrow disease     Cancer
    Acute hemorrhagic conjunctivitis

    Find genes that share disorders with CD55           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD55 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paroxysmal hemoglobinuria nocturnal 91.9 37 19154662 (2), 1688570 (1), 9516159 (1), 1281489 (1) (see all 30)
    hemolysis 66.3 27 9203959 (2), 1378912 (2), 11881969 (2), 7691484 (1) (see all 18)
    anemia aplastic 59.5 4 7544152 (2), 7686037 (1), 11930678 (1)
    hemoglobinuria 55.9 2 9844822 (1), 10539884 (1)
    swine vesicular disease 48 1 15831949 (1)
    anemia hemolytic 48 5 11930678 (1), 9892684 (1), 12213736 (1)
    somatic mutations 41.4 2 18376800 (1), 7522635 (1)
    anemia dyserythropoietic congenital 37.3 1 7506081 (1)
    pancytopenia 36.6 1 15103939 (1)
    enterovirus infections 33.9 1 15507656 (1)

    Genetic Association Database (GAD): CD55
    Human Genome Epidemiology (HuGE) Navigator: CD55 (12 documents)

    Export disorders for CD55 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD55 gene, integrated from 10 sources (see all 642):
    (articles sorted by number of sources associating them with CD55)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. (PubMed id 7519480)1, 2, 9 Lublin D.M.... Tanner M.J.A. (Blood 1994)
    2. Complete determination of disulfide bonds localized within the short consensus repeat units of decay accelerating factor (CD55 antigen). (PubMed id 1377029)1, 2, 9 Nakano Y.... Tomita M. (Biochim. Biophys. Acta 1992)
    3. Isolation of two forms of decay-accelerating factor (DAF) from human urine. (PubMed id 1712233)1, 2, 9 Nakano Y.... Tomita M. (Biochim. Biophys. Acta 1991)
    4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    6. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    7. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PubMed id 20673868)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)
    8. Associations between decay-accelerating factor polymorphisms and allergic respiratory diseases. (PubMed id 19681921)1, 4 Kawai T....Noguchi E. (Clin. Exp. Allergy 2009)
    9. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (Br. J. Haematol. 2009)
    10. Investigation of CBS, MTR, RFC-1 and TC polymorphisms as maternal risk factors for Down syndrome. (PubMed id 19729796)1, 4 Fintelman-Rodrigues N....Santos-RebouAsas C.B. (Dis. Markers 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1604 HGNC: 2665 AceView: DAF Ensembl:ENSG00000196352 euGenes: HUgn1604
    ECgene: CD55 Kegg: 1604 H-InvDB: CD55

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD55 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=cromer
    CD55basehttp://bioinf.uta.fi/CD55base/
    Wikipedia http://en.wikipedia.org/wiki/Decay_accelerating_factor
    SeattleSNPshttp://pga.gs.washington.edu/data/daf/
    Virus Particle ExploreR dbhttp://viperdb.scripps.edu/info_page.php?VDB=1upn

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD55 gene:
    Search GeneIP for patents involving CD55

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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