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Aliases for CD55 Gene

Aliases for CD55 Gene

  • CD55 Molecule (Cromer Blood Group) 2 3
  • CD55 Molecule, Decay Accelerating Factor For Complement (Cromer Blood Group) 2 3 5
  • CD55 Antigen 3 4
  • DAF 3 4
  • CR 3 4
  • Decay Accelerating Factor For Complement (CD55, Cromer Blood Group System) 2
  • CROM 3
  • TC 3

External Ids for CD55 Gene

Previous HGNC Symbols for CD55 Gene

  • DAF

Previous GeneCards Identifiers for CD55 Gene

  • GC01P205561
  • GC01P207494
  • GC01P178191

Summaries for CD55 Gene

Entrez Gene Summary for CD55 Gene

  • This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]

GeneCards Summary for CD55 Gene

CD55 (CD55 Molecule (Cromer Blood Group)) is a Protein Coding gene. Diseases associated with CD55 include autoimmune hemolytic anemia and paroxysmal nocturnal hemoglobinuria. Among its related pathways are Signaling by GPCR and Complement and coagulation cascades. GO annotations related to this gene include lipid binding and virus receptor activity. An important paralog of this gene is ENSG00000276911.

UniProtKB/Swiss-Prot for CD55 Gene

  • This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.

  • (Microbial infection) Acts as a receptor for coxsackievirus A21, coxsackieviruses B1, B3 and B5 (PubMed:9151867). Acts as a receptor for human enterovirus 70 and D68 (Probable) (PubMed:8764022). Acts as a receptor for human echoviruses 6, 7, 11, 12, 20 and 21 (PubMed:7525274).

Gene Wiki entry for CD55 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD55 Gene

Genomics for CD55 Gene

Regulatory Elements for CD55 Gene

Promoters for CD55 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD55 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD55 Gene

Chromosome:
1
Start:
207,321,472 bp from pter
End:
207,386,804 bp from pter
Size:
65,333 bases
Orientation:
Plus strand

Genomic View for CD55 Gene

Genes around CD55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD55 Gene

Proteins for CD55 Gene

  • Protein details for CD55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08174-DAF_HUMAN
    Recommended name:
    Complement decay-accelerating factor
    Protein Accession:
    P08174
    Secondary Accessions:
    • B1AP14
    • D3DT83
    • D3DT84
    • E7ER69
    • P09679
    • P78361
    • Q14UF2
    • Q14UF3
    • Q14UF4
    • Q14UF5
    • Q14UF6

    Protein attributes for CD55 Gene

    Size:
    381 amino acids
    Molecular mass:
    41400 Da
    Quaternary structure:
    • Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form).
    • (Microbial infection) Interacts with coxsackievirus A21, coxsackieviruses B1, B3 and B5 capsid proteins.
    • (Microbial infection) Interacts with human enterovirus 70 and D68 capsid proteins (Probable).
    • (Microbial infection) Interacts with human echoviruses 6, 7, 11, 12, 20 and 21 capsid proteins.

    Three dimensional structures from OCA and Proteopedia for CD55 Gene

    Alternative splice isoforms for CD55 Gene

neXtProt entry for CD55 Gene

Proteomics data for CD55 Gene at MOPED

Post-translational modifications for CD55 Gene

  • The Ser/Thr-rich domain is heavily O-glycosylated.
  • Glycosylation at Asn 95, Thr 343, and Thr 344
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CD55 Gene

Domains & Families for CD55 Gene

Protein Domains for CD55 Gene

Graphical View of Domain Structure for InterPro Entry

P08174

UniProtKB/Swiss-Prot:

DAF_HUMAN :
  • The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).
  • Belongs to the receptors of complement activation (RCA) family.
Domain:
  • The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).
  • Contains 4 Sushi (CCP/SCR) domains.
Family:
  • Belongs to the receptors of complement activation (RCA) family.
genes like me logo Genes that share domains with CD55: view

Function for CD55 Gene

Molecular function for CD55 Gene

UniProtKB/Swiss-Prot Function:
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for coxsackievirus A21, coxsackieviruses B1, B3 and B5 (PubMed:9151867). Acts as a receptor for human enterovirus 70 and D68 (Probable) (PubMed:8764022). Acts as a receptor for human echoviruses 6, 7, 11, 12, 20 and 21 (PubMed:7525274).

Gene Ontology (GO) - Molecular Function for CD55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9064337
genes like me logo Genes that share ontologies with CD55: view
genes like me logo Genes that share phenotypes with CD55: view

Animal Models for CD55 Gene

MGI Knock Outs for CD55:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD55

miRNA for CD55 Gene

miRTarBase miRNAs that target CD55

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD55 Gene

Localization for CD55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD55 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.
Isoform 6: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 7: Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD55 Gene COMPARTMENTS Subcellular localization image for CD55 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
golgi apparatus 4
nucleus 3
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 2433596
GO:0031225 anchored component of membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS --
genes like me logo Genes that share ontologies with CD55: view

Pathways & Interactions for CD55 Gene

genes like me logo Genes that share pathways with CD55: view

SIGNOR curated interactions for CD55 Gene

Activates:

Gene Ontology (GO) - Biological Process for CD55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006958 complement activation, classical pathway IEA --
GO:0045087 innate immune response IEA,TAS --
GO:0045730 respiratory burst NAS 8223854
GO:0046718 viral entry into host cell IEA --
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation IDA 16818763
genes like me logo Genes that share ontologies with CD55: view

Drugs & Compounds for CD55 Gene

(30) Drugs for CD55 Gene - From: Novoseek, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloramphenicol Approved Pharma Target, other 6
COXSACKIEVIRUS TYPE A21 Pharma 0
ONYVAX-105 (105AD7) Pharma 0

(27) Additional Compounds for CD55 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD55: view

Transcripts for CD55 Gene

Unigene Clusters for CD55 Gene

CD55 molecule, decay accelerating factor for complement (Cromer blood group):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD55 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - - - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for CD55 Gene

GeneLoc Exon Structure for
CD55
ECgene alternative splicing isoforms for
CD55

Expression for CD55 Gene

mRNA expression in normal human tissues for CD55 Gene

mRNA differential expression in normal tissues according to GTEx for CD55 Gene

This gene is overexpressed in Whole Blood (x14.6).

Protein differential expression in normal tissues from HIPED for CD55 Gene

This gene is overexpressed in Cerebrospinal fluid (23.6), Cervix (9.7), and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD55 Gene



SOURCE GeneReport for Unigene cluster for CD55 Gene Hs.126517

mRNA Expression by UniProt/SwissProt for CD55 Gene

P08174-DAF_HUMAN
Tissue specificity: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.
genes like me logo Genes that share expression patterns with CD55: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CD55 Gene

Orthologs for CD55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD55 36
  • 95 (a)
OneToOne
CD55 35
  • 98.86 (n)
  • 97.95 (a)
cow
(Bos Taurus)
Mammalia CD55 35
  • 72.34 (n)
  • 57.1 (a)
CD55 36
  • 35 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD55 36
  • 36 (a)
OneToOne
CD55 35
  • 72.31 (n)
  • 61.85 (a)
mouse
(Mus musculus)
Mammalia Cd55 35
  • 62.35 (n)
  • 50 (a)
Cd55 36
  • 44 (a)
OneToMany
Daf2 36
  • 41 (a)
OneToMany
Cd55b 16
oppossum
(Monodelphis domestica)
Mammalia CD55 36
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD55 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd55 35
  • 64.9 (n)
  • 50.78 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 18 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii rca2.1 36
  • 22 (a)
ManyToMany
rca2.2 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 6 (a)
OneToMany
Species with no ortholog for CD55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD55 Gene

ENSEMBL:
Gene Tree for CD55 (if available)
TreeFam:
Gene Tree for CD55 (if available)

Paralogs for CD55 Gene

genes like me logo Genes that share paralogs with CD55: view

Variants for CD55 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD55 Gene

P08174-DAF_HUMAN
Responsible for the Cromer blood group system (CROM) [MIM:613793]. It consists of at least 8 high-incidence (Cr(a), Tc(a), Dr(a), Es(a), WES(b), UMC, IFC and GUTI) and three low-incidence (Tc(b), Tc(c) and WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab there is reduced or absent expression of DAF, respectively. In the case of the Dr(a-) phenotype, a single nucleotide substitution within exon 5 accounts for two changes: a simple amino acid substitution, Leu-199 that is the basis of the antigenic variation, and an alternative splicing event that underlies the decreased expression of DAF in this phenotype. The Inab phenotype is a very rare one in which the red blood cells lack all Cromer system antigens. The red blood cells of individuals with Inab phenotype have a deficiency of DAF, but these individuals are not known to have any associated hematologic or other abnormalities (PubMed:12675719).

Sequence variations from dbSNP and Humsavar for CD55 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs28371588 -, - 207,322,436(+) AGGCC(A/C/G/T)TACAA nc-transcript-variant, reference, missense
rs147474393 - 207,322,526(+) CTGCC(G/T)TAAGG nc-transcript-variant, reference, missense
VAR_002000 -
rs60822373 - 207,331,122(+) GTCCA(C/G/T)CACCA nc-transcript-variant, reference, missense
VAR_015884 -

Structural Variations from Database of Genomic Variants (DGV) for CD55 Gene

Variant ID Type Subtype PubMed ID
dgv523n71 CNV Loss 21882294
nsv873131 CNV Gain 21882294
nsv873132 CNV Loss 21882294
esv2722084 CNV Deletion 23290073
nsv4221 CNV Loss 18451855
nsv508688 CNV Loss 20534489

Variation tolerance for CD55 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 27.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD55 Gene

HapMap Linkage Disequilibrium report
CD55
Human Gene Mutation Database (HGMD)
CD55
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

Disorders for CD55 Gene

MalaCards: The human disease database

(13) MalaCards diseases for CD55 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autoimmune hemolytic anemia
  • autoimmune haemolytic anaemia
paroxysmal nocturnal hemoglobinuria
  • marchiafava-micheli disease
hemoglobinuria
variola minor
  • alastrim
acute hemorrhagic conjunctivitis
  • apollo disease
- elite association - COSMIC cancer census association via MalaCards
Search CD55 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD55

Genetic Association Database (GAD)
CD55
Human Genome Epidemiology (HuGE) Navigator
CD55
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD55
genes like me logo Genes that share disorders with CD55: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD55 Gene

Publications for CD55 Gene

  1. Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. (PMID: 7519480) Lublin D.M. … Tanner M.J.A. (Blood 1994) 3 4 23 67
  2. A functional SNP in the regulatory region of the decay-accelerating factor gene associates with extraocular muscle pareses in myasthenia gravis. (PMID: 19675582) Heckmann J.M. … Prince S. (Genes Immun. 2010) 3 23
  3. The impact of expressions of CD97 and its ligand CD55 at the invasion front on prognosis of rectal adenocarcinoma. (PMID: 20339853) Han S.L. … Zeng Q.Q. (Int J Colorectal Dis 2010) 3 23
  4. Neutralization of complement regulatory proteins CD55 and CD59 augments therapeutic effect of herceptin against lung carcinoma cells. (PMID: 19424617) Zhao W.P. … Chen Z.T. (Oncol. Rep. 2009) 3 23
  5. Preterm labor: CD55 in maternal blood leukocytes. (PMID: 19341386) Nowicki S. … Nowicki B. (Am. J. Reprod. Immunol. 2009) 3 23

Products for CD55 Gene

Sources for CD55 Gene

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