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Aliases for CD55 Gene

Aliases for CD55 Gene

  • CD55 Molecule, Decay Accelerating Factor For Complement (Cromer Blood Group) 2 3
  • DAF 3 4 6
  • CD55 Antigen 3 4
  • CROM 3 6
  • CR 3 4
  • Decay Accelerating Factor For Complement (CD55, Cromer Blood Group System) 2
  • Complement Decay-Accelerating Factor 3
  • TC 3

External Ids for CD55 Gene

Previous Symbols for CD55 Gene

  • DAF

Summaries for CD55 Gene

Entrez Gene Summary for CD55 Gene

  • This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]

GeneCards Summary for CD55 Gene

CD55 (CD55 Molecule, Decay Accelerating Factor For Complement (Cromer Blood Group)) is a Protein Coding gene. Diseases associated with CD55 include acute hemorrhagic conjunctivitis and malaria. Among its related pathways are Signaling by GPCR and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include virus receptor activity and enzyme inhibitor activity. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for CD55 Gene

  • This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.

Gene Wiki entry for CD55 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD55 Gene

Genomics for CD55 Gene

Genomic Location for CD55 Gene

Start:
207,321,472 bp from pter
End:
207,360,966 bp from pter
Size:
39,495 bases
Orientation:
Plus strand

Genomic View for CD55 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD55 Gene

Regulatory Elements for CD55 Gene

Proteins for CD55 Gene

  • Protein details for CD55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08174-DAF_HUMAN
    Recommended name:
    Complement decay-accelerating factor
    Protein Accession:
    P08174
    Secondary Accessions:
    • B1AP14
    • D3DT83
    • D3DT84
    • E7ER69
    • P09679
    • P78361
    • Q14UF2
    • Q14UF3
    • Q14UF4
    • Q14UF5
    • Q14UF6

    Protein attributes for CD55 Gene

    Size:
    381 amino acids
    Molecular mass:
    41400 Da
    Quaternary structure:
    • Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Binds to coxsackievirus A21, coxsackieviruses B1, B3 and B5, human enterovirus 70, human echoviruses 6, 7, 11, 12, 20 and 21 capsid proteins and acts as a receptor for these viruses.

    Three dimensional structures from OCA and Proteopedia for CD55 Gene

    Alternative splice isoforms for CD55 Gene

neXtProt entry for CD55 Gene

Proteomics data for CD55 Gene at MOPED

Post-translational modifications for CD55 Gene

  • The Ser/Thr-rich domain is heavily O-glycosylated.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn95, Thr343, and Thr344

Other Protein References for CD55 Gene

No data available for DME Specific Peptides for CD55 Gene

Domains for CD55 Gene

Gene Families for CD55 Gene

HGNC:

Protein Domains for CD55 Gene

UniProtKB/Swiss-Prot:

DAF_HUMAN
Domain:
  • The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).:
    • P08174
  • Contains 4 Sushi (CCP/SCR) domains.:
    • P08174
Family:
  • Belongs to the receptors of complement activation (RCA) family.:
    • P08174
genes like me logo Genes that share domains with CD55: view

Function for CD55 Gene

Molecular function for CD55 Gene

UniProtKB/Swiss-Prot Function: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.

Gene Ontology (GO) - Molecular Function for CD55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 7525274
GO:0004857 enzyme inhibitor activity --
GO:0005515 protein binding IPI 9064337
GO:0008289 lipid binding IDA 12731067
genes like me logo Genes that share ontologies with CD55: view
genes like me logo Genes that share phenotypes with CD55: view

Animal Models for CD55 Gene

MGI Knock Outs for CD55:

miRNA for CD55 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD55 Gene

Localization for CD55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD55 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Secreted.
Isoform 6: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 7: Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD55 Gene COMPARTMENTS Subcellular localization image for CD55 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 2
cytoskeleton 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2433596
GO:0009986 cell surface IDA 15907827
GO:0016324 apical plasma membrane --
genes like me logo Genes that share ontologies with CD55: view

Pathways for CD55 Gene

genes like me logo Genes that share pathways with CD55: view

Pathways by source for CD55 Gene

Gene Ontology (GO) - Biological Process for CD55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006958 complement activation, classical pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 8223854
GO:0007283 spermatogenesis --
GO:0009615 response to virus --
GO:0030449 regulation of complement activation TAS --
genes like me logo Genes that share ontologies with CD55: view

Compounds for CD55 Gene

(1) Drugbank Compounds for CD55 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Chloramphenicol
  • CAF
56-75-7 target other

(55) Novoseek inferred chemical compound relationships for CD55 Gene

Compound -log(P) Hits PubMed IDs
dafs 81.2 3
anaphylatoxin 52.8 1
rituximab 44.9 20
phosphatidylinositol 41.8 14
glycolipid 41.1 8
genes like me logo Genes that share compounds with CD55: view

Transcripts for CD55 Gene

Unigene Clusters for CD55 Gene

CD55 molecule, decay accelerating factor for complement (Cromer blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD55 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - - - -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for CD55 Gene

GeneLoc Exon Structure for
CD55
ECgene alternative splicing isoforms for
CD55

Expression for CD55 Gene

mRNA expression in normal human tissues for CD55 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD55 Gene

This gene is overexpressed in Whole Blood (14.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CD55 Gene

SOURCE GeneReport for Unigene cluster for CD55 Gene Hs.126517

mRNA Expression by UniProt/SwissProt for CD55 Gene

P08174-DAF_HUMAN
Tissue specificity: Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix
genes like me logo Genes that share expressions with CD55: view

Orthologs for CD55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD55 36
  • 98.86 (n)
  • 97.95 (a)
CD55 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD55 36
  • 72.34 (n)
  • 57.1 (a)
CD55 37
  • 35 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD55 36
  • 72.31 (n)
  • 61.85 (a)
CD55 37
  • 36 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd55 36
  • 62.35 (n)
  • 50 (a)
Cd55 16
Cd55 37
  • 44 (a)
OneToMany
Daf2 37
  • 41 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CD55 37
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD55 37
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd55 36
  • 64.9 (n)
  • 50.78 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 18 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii rca2.1 37
  • 22 (a)
ManyToMany
rca2.2 37
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 6 (a)
OneToMany
Species with no ortholog for CD55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD55 Gene

ENSEMBL:
Gene Tree for CD55 (if available)
TreeFam:
Gene Tree for CD55 (if available)

Paralogs for CD55 Gene

Paralogs for CD55 Gene

Selected SIMAP similar genes for CD55 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CD55: view

Variants for CD55 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD55 Gene

P08174-DAF_HUMAN
Responsible for the Cromer blood group system (CROM) [MIM:613793]. It consists of at least 8 high-incidence (Cr(a), Tc(a), Dr(a), Es(a), WES(b), UMC, IFC and GUTI) and three low-incidence (Tc(b), Tc(c) and WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab there is reduced or absent expression of DAF, respectively. In the case of the Dr(a-) phenotype, a single nucleotide substitution within exon 5 accounts for two changes: a simple amino acid substitution, Leu-199 that is the basis of the antigenic variation, and an alternative splicing event that underlies the decreased expression of DAF in this phenotype. The Inab phenotype is a very rare one in which the red blood cells lack all Cromer system antigens. The red blood cells of individuals with Inab phenotype have a deficiency of DAF, but these individuals are not known to have any associated hematologic or other abnormalities

Sequence variations from dbSNP and Humsavar for CD55 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs925130 -- 207,330,087(+) TTTGC(A/G)CTTCC intron-variant
rs925131 -- 207,330,376(+) ATGTG(A/G)AACCA intron-variant
rs1042390 -- 207,359,639(+) TACAC(A/C)CAAGT utr-variant-3-prime, reference, synonymous-codon, nc-transcript-variant
rs1042662 -- 207,360,326(+) TATTT(C/T)TGAAT utr-variant-3-prime, nc-transcript-variant
rs1134623 -- 207,353,093(+) ctgtc(A/C)cccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD55 Gene

Variant ID Type Subtype PubMed ID
dgv523n71 CNV Loss 21882294
nsv873131 CNV Gain 21882294
nsv873132 CNV Loss 21882294
esv2722084 CNV Deletion 23290073
nsv4221 CNV Loss 18451855
nsv508688 CNV Loss 20534489

Relevant External Links for CD55 Gene

HapMap Linkage Disequilibrium report
CD55
Human Gene Mutation Database (HGMD)
CD55
Locus Specific Mutation Databases (LSDB)
CD55
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group

Disorders for CD55 Gene

(1) OMIM Diseases for CD55 Gene (125240)

(5) University of Copenhagen DISEASES for CD55 Gene

(95) Novoseek inferred disease relationships for CD55 Gene

Disease -log(P) Hits PubMed IDs
paroxysmal hemoglobinuria nocturnal 91.9 31
hemolysis 66.3 21
anemia aplastic 59.5 4
hemoglobinuria 55.9 2
swine vesicular disease 48 1

Relevant External Links for CD55

Genetic Association Database (GAD)
CD55
Human Genome Epidemiology (HuGE) Navigator
CD55
genes like me logo Genes that share disorders with CD55: view

No data available for UniProtKB/Swiss-Prot for CD55 Gene

Publications for CD55 Gene

  1. Complete determination of disulfide bonds localized within the short consensus repeat units of decay accelerating factor (CD55 antigen). (PMID: 1377029) Nakano Y. … Tomita M. (Biochim. Biophys. Acta 1992) 3 4 23
  2. Isolation of two forms of decay-accelerating factor (DAF) from human urine. (PMID: 1712233) Nakano Y. … Tomita M. (Biochim. Biophys. Acta 1991) 3 4 23
  3. Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes. (PMID: 7519480) Lublin D.M. … Tanner M.J.A. (Blood 1994) 3 4 23
  4. Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1. (PMID: 1385527) Shenoy-Scaria A.M. … Lublin D.M. (J. Immunol. 1992) 3 23
  5. Expression of decay-accelerating factor (CD55) of the complement system on human spermatozoa. (PMID: 7687624) Cervoni F. … Hsi B.L. (J. Immunol. 1993) 3 23

Products for CD55 Gene

Sources for CD55 Gene

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