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Aliases & Descriptions for CD53
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases MOX44 2 , 3 , 5 OTTHUMP00000013686 2 OTTHUMP00000059505 2 TSPAN25 1 , 2 , 3 Tetraspanin-25 3 Tspan-25 3 tetraspanin-25 2
Descriptions CD53 antigen 1 , 2 , 3 CD53 glycoprotein 2 CD53 molecule 2 CD53 tetraspan antigen 2 Cell surface glycoprotein CD53 3 antigen MOX44 identified by monoclonal antibody MRC-OX44 2 cell surface antigen 2 leukocyte surface antigen CD53 2 transmembrane glycoprotein 2
Search outside databases for aliases for CD53 genePrevious GC identifers: GC01P111831 GC01P110282 GC01P110516 GC01P110714
Summaries for CD53 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for CD53 : The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as thetetraspanin family. Most of these members are cell-surface proteins that are characterized by thepresence of four hydrophobic domains. The proteins mediate signal transduction events that play arole in the regulation of cell development, activation, growth and motility. This encoded proteinis a cell surface glycoprotein that is known to complex with integrins. It contributes to thetransduction of CD2-generated signals in T cells and natural killer cells and has been suggestedto play a role in growth regulation. Familial deficiency of this gene has been linked to animmunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi andviruses. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq] UniProtKB/Swiss-Prot: CD53_HUMAN, P19397 Function : May be involved in growth regulation in hematopoietic cells
Gene Wiki entry for CD53
Genomic Location for CD53
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the CD53 gene Entrez Gene cytogenetic band: 1p13 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13 CD53 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P111127:
(about GC identifiers )
Start:
111,215,344 bp from pter
End:
111,244,081 bp from pter
Size:
28,738 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000001.9 NT_019273.18 Proteins for CD53
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: CD53_HUMAN, P19397 (See
protein sequence )Recommended Name: Leukocyte surface antigen CD53 Size : 219 amino acids; 24341 Da
Subcellular location : Membrane; Multi-pass membrane protein
Secondary accessions : Q5U0D6
REFSEQ proteins (2 alternative transcripts):
NP_000551.1 NP_001035122.1 ENSEMBL proteins: ENSP00000271324 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for CD53: Assays for CD53:
Protein
Domains/ Families for CD53(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P19397 ProtoNet protein and cluster: P19397
1 Blocks protein family : IPB000301 Transmembrane four family signature UniProtKB/Swiss-Prot: CD53_HUMAN, P19397 Similarity : Belongs to the tetraspanin (TM4SF) family
Gene Function for CD53
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_000560 Applied Biosystems Silencer ® siRNAs for CD53 Sigma-Aldrich siRNA and siRNA Panels for CD53 Sigma-Aldrich shRNA for CD53 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_000560                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_000560                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_000560  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000560 UniProtKB/Swiss-Prot: CD53_HUMAN, P19397 Function : May be involved in growth regulation in hematopoietic cells
Genatlas biochemistry entry for CD53 :cell differentiation antigen 53,32-40kDa,single chain glycoprotein,identified by monoclonalantibodies H129,H136,MEM-53,HD77,see MOX44 Pathways & Interactions for CD53
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for CD53 5/13 Interacting proteins for CD53 (ENSP00000271324 3 ) via UniProtKB, MINT, and/or STRING (see all 13
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
About this table
Drugs & Compounds for CD53 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for CD53
Transcripts for CD53(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_000560 Sigma-Aldrich siRNA and siRNA Panels for CD53 Sigma-Aldrich shRNA for CD53 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_000560 NM_001040033
REFSEQ mRNAs for CD53 gene (2 alternative transcripts): NM_000560.3 NM_001040033.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000560 NM_001040033
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_000560                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_000560                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_000560  
Additional cDNA sequence: AK298723.1 AK313582.1 BC035456.1 BC040693.1 BT019643.1 CR592401.1 CR598355.1 CR605120.1 CR609698.1 CR614019.1 CR619551.1 CR620545.1 M37033.1 M60871.1
20 DOTS entries : DT.92433604 DT.100819256 DT.100019308 DT.99943676 DT.121382896 DT.209137 DT.121382848 DT.92433596 DT.95109186 DT.100026950 DT.100819258 DT.121382833 DT.121382890 DT.91819522 DT.100772197 DT.100819257 DT.100819261 DT.75111548 DT.92433595 DT.95109190
24/326 AceView cDNA sequences (see all 326
):CR592401 AW575174 BI770932 AL602018 AI022073 BC040693 AI243017 AI040645 BU073271 CR620545 CK429291 BM457687 CR609698 CD365726 AA742256 CR614019 CR619551 AI076089 AA897735 BX378202 BP338495 AA810480 CD364590 BP367968
highest scoring ESTs for CD53 :M37033 AA362173 AA362399 AA362408 AA648126 AA770669 AA773833 AA872291 AA884893 AA894962
Unigene Cluster for CD53: CD53 molecule Hs.443057 [show with all ESTs ] Unigene Representative Sequence: NM_001040033 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CD53 (see all 10
) ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c SP1 :   -           -   -           -     -               SP2 :             -   -           -     -               SP3 :             -   -           -     -   -             SP4 :   -           -   -       -   -   -   -   -   -   -   -         SP5 :             -   -           -                  
About this scheme ECgene alternative splicing isoforms for CD53 1 Ensembl transcript including schematic representation : ENST00000271324
Expression for CD53
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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CD53 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for CD53 1 / 2 / 3
3 probe-sets matching CD53 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AAGCCCTACASOURCE GeneReport for Unigene cluster: Hs.443057 Expression variation in blood from EXPOLDB for CD53
UniProtKB/Swiss-Prot: CD53_HUMAN, P19397 Tissue specificity : B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positivethymocytes and peripheral T-cells
Orthologs for CD53
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for CD53 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for CD53 ENSEMBL Gene Tree for CD53 Paralogs for CD53 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for CD53 gene TSPAN9 2 TSPAN4 2 Pseudogenes 1 related pseudogene
SNPs/Variants for CD53 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for CD53 (up to first 250kb)
Disorders & Mutations for CD53
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 151525 1 Novoseek disease relationship for CD53 gene
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
tumors
0.00
4
12606948 (2), 15931266 (1)
About this table
Medical News for CD53 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for CD53 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/54 PubMed articles for CD53 gene (see all 54
): The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens. (PubMed id 1700763) 1, 3, 4 Angelisova P.... Horejsi V. (1990) Genomic structure of the human CD53 gene. (PubMed id 8319976) 1, 2, 3 Korinek V. and Horejsi V. (1993) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Identification and analysis of cDNA clones encoding CD53. A pan- leukocyte antigen related to membrane transport proteins. (PubMed id 2258620) 3, 4 Amiot M. (1990) Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication. (PubMed id 8452817) 1, 3 Wright M.D....Williams A.F. (1993) Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. (PubMed id 8816400) 1, 3 Szollosi J....Damjanovich S. (1996) Apoptosis protection and survival signal by the CD53 tetraspanin antigen. (PubMed id 12606948) 1, 3 Yunta M. and Lazo P.A. (2003) Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. (PubMed id 11959120) 1, 3 Charrin S....Rubinstein E. (2002) Functional expression of transmembrane 4 superfamily molecules on human eosinophils. (PubMed id 10529602) 1, 3 Matsumoto K....Kurashige T. (1999)
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Genome Databases showing CD53
(According to
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euGenes ,
Ensembl ,
miRBase ,
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and/or
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Other Databases showing CD53
(According to HUGE )
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Specialized Databases showing CD53 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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