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Aliases for CD53 Gene

Aliases for CD53 Gene

  • CD53 Molecule 2 3 5
  • CD53 Antigen 2 3 4
  • Cell Surface Glycoprotein CD53 3 4
  • Tetraspanin-25 3 4
  • Tspan-25 3 4
  • TSPAN25 3 4
  • MOX44 3 4
  • Antigen MOX44 Identified By Monoclonal Antibody MRC-OX44 3
  • Leukocyte Surface Antigen CD53 3
  • Transmembrane Glycoprotein 3
  • CD53 Tetraspan Antigen 3
  • Cell Surface Antigen 3
  • CD53 Glycoprotein 3

External Ids for CD53 Gene

Previous HGNC Symbols for CD53 Gene

  • MOX44

Previous GeneCards Identifiers for CD53 Gene

  • GC01P111831
  • GC01P110282
  • GC01P110516
  • GC01P110714
  • GC01P111127
  • GC01P111413
  • GC01P109285

Summaries for CD53 Gene

Entrez Gene Summary for CD53 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for CD53 Gene

CD53 (CD53 Molecule) is a Protein Coding gene. Diseases associated with CD53 include Intestinal Tuberculosis and Gastrointestinal Tuberculosis. Among its related pathways are Immune System. An important paralog of this gene is TSPAN9.

UniProtKB/Swiss-Prot for CD53 Gene

  • Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).

Gene Wiki entry for CD53 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD53 Gene

Genomics for CD53 Gene

Regulatory Elements for CD53 Gene

Enhancers for CD53 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F110870 1.3 FANTOM5 ENCODE 21.1 +5.8 5776 12.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B YY1 ZNF143 FOS SP5 CD53 LINC01160 DRAM2 KCNA3 LRIF1 ENSG00000261654
GH01F110630 1.5 FANTOM5 Ensembl ENCODE 15.4 -235.5 -235499 10.6 HDGF TBL1XR1 WRNIP1 ZBTB40 RAD21 EGR1 SCRT2 ZNF143 ETV6 KLF7 CD53 KCNA3 KCNA2 KCNA10 KCNC4-AS1 LRIF1 RBM15 ENSG00000259834
GH01F110645 1 FANTOM5 Ensembl ENCODE 11.7 -223.8 -223796 4.4 FEZF1 ZNF2 FOS SP3 JUNB REST TSHZ1 ZNF488 ZNF518A ZNF264 NRBF2P3 ENSG00000235005 HIGD1AP12 KCNA3 CD53 ENSG00000258634 CEPT1 ENSG00000243960 DRAM2 LRIF1
GH01F110784 1.4 FANTOM5 Ensembl ENCODE 10.9 -84.5 -84531 4.4 BCOR ASH2L RBBP5 FEZF1 ZEB1 RELA ZNF664 ZNF316 CBX5 POLR2A KCNA2 CD53 KCNA10 DENND2D DRAM2 ENSG00000199710 GC01M110765 GC01P110827
GH01F111185 1.6 FANTOM5 Ensembl ENCODE 10.9 +324.5 324538 21.3 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DRAM2 KCND3-AS1 CEPT1 HIGD1AP12 NRBF2P3 CHI3L2 ENSG00000243960 DDX20 ENSG00000273373 DENND2D
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CD53 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD53 Gene

110,871,199 bp from pter
110,899,936 bp from pter
28,738 bases
Plus strand

Genomic View for CD53 Gene

Genes around CD53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD53 Gene

Proteins for CD53 Gene

  • Protein details for CD53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte surface antigen CD53
    Protein Accession:
    Secondary Accessions:
    • B2R905
    • Q5U0D6

    Protein attributes for CD53 Gene

    219 amino acids
    Molecular mass:
    24341 Da
    Quaternary structure:
    • Interacts with SCIMP.

neXtProt entry for CD53 Gene

Post-translational modifications for CD53 Gene

  • Glycosylation at Asn 129 and Asn 148

Other Protein References for CD53 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD53 Gene

Domains & Families for CD53 Gene

Gene Families for CD53 Gene

Suggested Antigen Peptide Sequences for CD53 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD53: view

Function for CD53 Gene

Molecular function for CD53 Gene

GENATLAS Biochemistry:
cell differentiation antigen 53,32-40kDa,single chain glycoprotein,identified by monoclonal antibodies H129,H136,MEM-53,HD77,see MOX44
UniProtKB/Swiss-Prot Function:
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).

Gene Ontology (GO) - Molecular Function for CD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21930792
genes like me logo Genes that share ontologies with CD53: view
genes like me logo Genes that share phenotypes with CD53: view

Animal Model Products

miRNA for CD53 Gene

miRTarBase miRNAs that target CD53

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD53 Gene

Localization for CD53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD53 Gene

Cell membrane. Cell junction. Membrane; Multi-pass membrane protein. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CD53 Gene COMPARTMENTS Subcellular localization image for CD53 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endosome 1

Gene Ontology (GO) - Cellular Components for CD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 21930792
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005911 cell-cell junction ISS --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with CD53: view

Pathways & Interactions for CD53 Gene

SuperPathways for CD53 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with CD53: view

Pathways by source for CD53 Gene

2 Reactome pathways for CD53 Gene

Gene Ontology (GO) - Biological Process for CD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8404042
GO:0007166 cell surface receptor signaling pathway IBA --
GO:1901741 positive regulation of myoblast fusion ISS --
genes like me logo Genes that share ontologies with CD53: view

No data available for SIGNOR curated interactions for CD53 Gene

Transcripts for CD53 Gene

Unigene Clusters for CD53 Gene

CD53 molecule:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD53 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - - -
SP5: - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -

Relevant External Links for CD53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD53 Gene

This gene is overexpressed in Whole Blood (x28.6) and Spleen (x4.0).

Protein differential expression in normal tissues from HIPED for CD53 Gene

This gene is overexpressed in Lymph node (20.6), Neutrophil (9.3), Monocytes (8.9), and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD53 Gene

Protein tissue co-expression partners for CD53 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD53 Gene:


SOURCE GeneReport for Unigene cluster for CD53 Gene:


mRNA Expression by UniProt/SwissProt for CD53 Gene:

Tissue specificity: B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.
genes like me logo Genes that share expression patterns with CD53: view

Primer Products

Orthologs for CD53 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD53 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD53 34 35
  • 99.85 (n)
(Canis familiaris)
Mammalia CD53 34 35
  • 87.6 (n)
(Bos Taurus)
Mammalia CD53 34 35
  • 87.52 (n)
(Mus musculus)
Mammalia Cd53 34 16 35
  • 82.95 (n)
(Rattus norvegicus)
Mammalia Cd53 34
  • 82.5 (n)
(Monodelphis domestica)
Mammalia CD53 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia CD53 35
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496085 34
  • 59.72 (n)
(Danio rerio)
Actinopterygii zgc:64051 34
  • 51.9 (n)
CD53 35
  • 40 (a)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Tsp5D 35
  • 19 (a)
(Caenorhabditis elegans)
Secernentea tsp-8 35
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
Species where no ortholog for CD53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD53 Gene

Gene Tree for CD53 (if available)
Gene Tree for CD53 (if available)

Paralogs for CD53 Gene

(15) SIMAP similar genes for CD53 Gene using alignment to 2 proteins: Pseudogenes for CD53 Gene

genes like me logo Genes that share paralogs with CD53: view

Variants for CD53 Gene

Sequence variations from dbSNP and Humsavar for CD53 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10494122 -- 110,874,477(+) ATATC(A/C)TACTA intron-variant
rs10494123 -- 110,890,902(+) ATATG(C/T)TCCCC intron-variant
rs10494124 -- 110,896,922(+) TTAGA(C/T)TAGAG intron-variant
rs10629482 -- 110,899,908(+) TAAAA(-/AC/CA)GTTTA intron-variant, utr-variant-3-prime
rs10776716 -- 110,885,288(+) gctca(C/T)gcctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD53 Gene

Variant ID Type Subtype PubMed ID
esv3894023 CNV loss 25118596
nsv522939 CNV loss 19592680
nsv831037 CNV gain 17160897

Variation tolerance for CD53 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD53 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD53 Gene

Disorders for CD53 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CD53 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intestinal tuberculosis
  • tuberculosis of intestine
gastrointestinal tuberculosis
  • tuberculosis of gastrointestinal tract
- elite association - COSMIC cancer census association via MalaCards
Search CD53 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD53

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CD53: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD53 Gene

Publications for CD53 Gene

  1. Genomic structure of the human CD53 gene. (PMID: 8319976) KorA-nek V. … HorejsA- V. (Immunogenetics 1993) 2 3 22 64
  2. The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens. (PMID: 1700763) Angelisova P. … Horejsi V. (Immunogenetics 1990) 3 4 22 64
  3. Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response. (PMID: 21993531) Kuparinen T. … Hurme M. (Genes Immun. 2012) 3 46 64
  4. SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling. (PMID: 21930792) Draber P. … Brdicka T. (Mol. Cell. Biol. 2011) 3 4 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for CD53 Gene

Sources for CD53 Gene

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