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CD53 Gene

protein-coding   GIFtS: 57
GCID: GC01P111413

CD53 Molecule

(Previous name: CD53 antigen)
(Previous symbol: MOX44)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD53 Molecule1 2     Cell Surface Antigen2
MOX441 2 3 5     Leukocyte Surface Antigen CD532
CD53 Antigen1 2 3     tetraspanin-252
Cell Surface Glycoprotein CD532 3     Transmembrane Glycoprotein2
TSPAN252 3     tspan-252
Antigen MOX44 Identified By Monoclonal Antibody MRC-OX442     Tetraspanin-253
CD53 Glycoprotein2     Tspan-253
CD53 Tetraspan Antigen2     

External Ids:    HGNC: 16861   Entrez Gene: 9632   Ensembl: ENSG000001431197   OMIM: 1515255   UniProtKB: P193973   

Export aliases for CD53 gene to outside databases

Previous GC identifers: GC01P111831 GC01P110282 GC01P110516 GC01P110714 GC01P111127 GC01P109285


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD53 Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known
to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural
killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has
been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and
viruses. Alternative splicing results in multiple transcript variants encoding the same protein. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CD53 Gene:
CD53 (CD53 molecule) is a protein-coding gene. Diseases associated with CD53 include phagocyte bactericidal dysfunction, and intestinal tuberculosis. An important paralog of this gene is TSPAN2.

UniProtKB/Swiss-Prot: CD53_HUMAN, P19397
Function: Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be
involved in growth regulation in hematopoietic cells (By similarity)

Gene Wiki entry for CD53 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD53 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD53 promoter sequence
   Search Chromatin IP Primers for CD53

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13

CD53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD53 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P111413:  view genomic region     (about GC identifiers)

Start:
111,413,821 bp from pter      End:
111,442,558 bp from pter
Size:
28,738 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD53_HUMAN, P19397 (See protein sequence)
Recommended Name: Leukocyte surface antigen CD53  
Size: 219 amino acids; 24341 Da
Subunit: Interacts with SCIMP
Secondary accessions: B2R905 Q5U0D6

Explore the universe of human proteins at neXtProt for CD53: NX_P19397

Explore proteomics data for CD53 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn129, Asn148

  • See CD53 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000551.1  NP_001035122.1  

    ENSEMBL proteins: 
     ENSP00000271324   ENSP00000412250  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P19397

    ProtoNet protein and cluster: P19397

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: CD53_HUMAN, P19397
    Similarity: Belongs to the tetraspanin (TM4SF) family


    CD53 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD53_HUMAN, P19397
    Function: Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be
    involved in growth regulation in hematopoietic cells (By similarity)

         Genatlas biochemistry entry for CD53:
    cell differentiation antigen 53,32-40kDa,single chain glycoprotein,identified by monoclonal antibodies
    H129,H136,MEM-53,HD77,see MOX44

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CD53 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-875-3p hsa-miR-34b hsa-miR-431 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidCD53 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD53


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD53_HUMAN, P19397: Cell membrane (By similarity). Cell junction (By similarity). Membrane; Multi-pass membrane
    protein. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells
    of fused myotubes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA--
    GO:0005886plasma membrane ISS--
    GO:0005911cell-cell junction ISS--
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane IEA--

    CD53 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD53
    Interactions:

        GeneGlobe Interaction Network for CD53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for CD53 (P193973 ENSP000002713244) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD2P067293, ENSP000003584904I2D: score=3 STRING: ENSP00000358490
    IL2P605683, ENSP000002267304I2D: score=1 STRING: ENSP00000226730
    IL4P051123, ENSP000002314494I2D: score=1 STRING: ENSP00000231449
    CD9P219263, ENSP000000091804I2D: score=3 STRING: ENSP00000009180
    GGT1P194403, ENSP000002489234I2D: score=1 STRING: ENSP00000248923
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS8404042
    GO:1901741positive regulation of myoblast fusion ISS--

    CD53 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD53



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD53 gene (2 alternative transcripts): 
    NM_000560.3  NM_001040033.1  

    Unigene Cluster for CD53:

    CD53 molecule
    Hs.443057  [show with all ESTs]
    Unigene Representative Sequence: NM_001040033
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000271324(uc001dzw.3 uc001dzx.3 uc010owa.2) ENST00000471220
    ENST00000476408 ENST00000497404 ENST00000464329 ENST00000429072
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CD53:
    hsa-miR-875-3p hsa-miR-34b hsa-miR-431 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidCD53 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD53
      QuantiTect SYBR Green Assays in human, mouse, rat CD53
      QuantiFast Probe-based Assays in human, mouse, rat CD53

    Additional mRNA sequence: 

    AK298723.1 AK313582.1 BC035456.1 BC040693.1 BT019643.1 M37033.1 M60871.1 

    19 DOTS entries:

    DT.92433604  DT.100819256  DT.99943676  DT.121382896  DT.209137  DT.100019308  DT.121382848  DT.92433596 
    DT.95109186  DT.100026950  DT.100819258  DT.121382833  DT.121382890  DT.91819522  DT.100819257  DT.100819261 
    DT.75111548  DT.92433595  DT.95109190 

    Selected AceView cDNA sequences (see all 326):

    CR620545 BC040693 CR614019 AA897735 BC035456 AK124172 BP338495 CR592401 
    H98696 AL602018 CD365726 BU073271 AA383886 AA742256 H70124 AI040645 
    BX378202 CR605120 AI022073 BX381661 AI032692 AW575263 AI076089 CR609698 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD53 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:        -                             -     -                             -           -                                       
    SP2:                                      -     -                             -           -                                       
    SP3:                                      -     -                             -           -     -                                 
    SP4:        -                             -     -                 -     -     -     -     -     -     -     -                     
    SP5:                                      -     -                             -                                                   


    ECgene alternative splicing isoforms for CD53

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD53 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCCTACA
    CD53 Expression
    About this image


    CD53 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Lung (Respiratory System)
    CD53 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD53 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443057

    UniProtKB/Swiss-Prot: CD53_HUMAN, P19397
    Tissue specificity: B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and
    peripheral T-cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD53

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CD53 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd531 , 5 CD53 antigen1, 5 82.95(n)1
    83.11(a)1
      3 (46.53 cM)5
    125081  NM_007651.31  NP_031677.11 
     1067588615 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    many ↔ many
    AAWZ02036910(2483-9215)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004960851 leukocyte surface antigen CD53-like 59.72(n)
    55.56(a)
      100496085  XM_002942788.2  XP_002942834.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053225.12   -- 74.25(n)   393342  BC053225.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp5D6
    Tetraspanin 5D
    19(a)
    1 → many
    X(5963164-5968890)
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-86
    Protein TSP-8 (tsp-8) mRNA, complete cds
    24(a)
    1 → many
    X(14726626-14729482) WBGene00006634


    ENSEMBL Gene Tree for CD53 (if available)
    TreeFam Gene Tree for CD53 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD53 gene
    TSPAN22  CD92  TSPAN12  CD372  TSPAN92  CD822  TSPAN182  CD812  
    TSPAN42  TSPAN82  
    15 SIMAP similar genes for CD53 using alignment to 2 protein entries:     CD53_HUMAN (see all proteins):
    TSPAN4    TSPAN9    TSPAN18    CD82    CD151    CD37
    CD9    TSPAN5    TSPAN17    TSPAN1    TSPAN8    CD81
    TSPAN11    TSPAN2    TSPAN3

    CD53 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD53
    PGOHUM00000245999


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD53 (see all 602)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857618421,2
    --111411881(+) CACACA/GCATGT 1 -- us2k10--------
    rs1902384141,2
    --111411925(+) AGACAC/TGGAAT 1 -- us2k10--------
    rs1809349871,2
    --111411970(+) AGAAAA/GTGTGG 1 -- us2k10--------
    rs1411878961,2
    --111412016(+) AAAGA-/ATG   
       AGATG
    ATGTT
    1 -- us2k10--------
    rs1400657921,2
    --111412059(+) GAGGGA/CCTTAT 1 -- us2k10--------
    rs561040201,2
    C,F--111412151(+) TGGACG/ACAAAG 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1440207411,2
    --111412152(+) GGACGC/TAAAGA 1 -- us2k10--------
    rs1473247961,2
    --111412196(+) TGGAGC/TGGGGA 1 -- us2k10--------
    rs1855032941,2
    --111412197(+) GGAGCA/GGGGAA 1 -- us2k10--------
    rs1410619891,2
    C--111412257(+) GGGTGA/GTGAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD53 (111413821 - 111442558 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD53:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv330n71CNV Loss21882294
    nsv522939CNV Loss19592680
    nsv831037CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151525    OMIM disorders: --

    13 diseases for CD53:    
    About MalaCards
    phagocyte bactericidal dysfunction    intestinal tuberculosis    leukocyte adhesion deficiency    tuberculosis
    hepatitis b    type 1 diabetes    rheumatoid arthritis    arthritis
    asthma    hepatitis    obesity    melanoma
    hiv-1

    2 diseases from the University of Copenhagen DISEASES database for CD53:
    Intestinal tuberculosis     leukocyte-adhesion deficiency syndrome

    CD53 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CD53 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 12606948 (2), 15931266 (1)

    Genetic Association Database (GAD): CD53
    Human Genome Epidemiology (HuGE) Navigator: CD53 (4 documents)

    Export disorders for CD53 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD53 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with CD53)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens. (PubMed id 1700763)1, 2, 9 Angelisova P.... Horejsi V. (Immunogenetics 1990)
    2. Genomic structure of the human CD53 gene. (PubMed id 8319976)1, 3, 9 KorA-nek V. and HorejsA- V. (Immunogenetics 1993)
    3. Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response. (PubMed id 21993531)1, 4 Kuparinen T....Hurme M. (Genes Immun. 2012)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification and analysis of cDNA clones encoding CD53. A pan- leukocyte antigen related to membrane transport proteins. (PubMed id 2258620)1, 2 Amiot M. (J. Immunol. 1990)
    8. Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. (PubMed id 8816400)1, 9 SzAPllA^si J....Damjanovich S. (J. Immunol. 1996)
    9. Apoptosis protection and survival signal by the CD53 tetraspanin antigen. (PubMed id 12606948)1, 9 Yunta M. and Lazo P.A. (Oncogene 2003)
    10. Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation. (PubMed id 11959120)1, 9 Charrin S....Rubinstein E. (FEBS Lett. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 963 HGNC: 1686 AceView: CD53 Ensembl:ENSG00000143119 euGenes: HUgn963
    ECgene: CD53 H-InvDB: CD53

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD53 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD53 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD53 gene:
    Search GeneIP for patents involving CD53

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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