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Aliases for CD53 Gene

Aliases for CD53 Gene

  • CD53 Molecule 2 3
  • CD53 Antigen 2 3 4
  • MOX44 3 4 6
  • Cell Surface Glycoprotein CD53 3 4
  • Tetraspanin-25 3 4
  • Tspan-25 3 4
  • TSPAN25 3 4
  • Antigen MOX44 Identified By Monoclonal Antibody MRC-OX44 3
  • Leukocyte Surface Antigen CD53 3
  • Transmembrane Glycoprotein 3
  • CD53 Tetraspan Antigen 3
  • Cell Surface Antigen 3
  • CD53 Glycoprotein 3

External Ids for CD53 Gene

Previous HGNC Symbols for CD53 Gene

  • MOX44

Previous GeneCards Identifiers for CD53 Gene

  • GC01P111831
  • GC01P110282
  • GC01P110516
  • GC01P110714
  • GC01P111127
  • GC01P111413
  • GC01P109285

Summaries for CD53 Gene

Entrez Gene Summary for CD53 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD53 Gene

CD53 (CD53 Molecule) is a Protein Coding gene. Diseases associated with CD53 include intestinal tuberculosis. An important paralog of this gene is TSPAN9.

UniProtKB/Swiss-Prot for CD53 Gene

  • Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).

Gene Wiki entry for CD53 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD53 Gene

Genomics for CD53 Gene

Regulatory Elements for CD53 Gene

Transcription factor binding sites by QIAGEN in the CD53 gene promoter:

Genomic Location for CD53 Gene

Start:
110,871,199 bp from pter
End:
110,899,936 bp from pter
Size:
28,738 bases
Orientation:
Plus strand

Genomic View for CD53 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD53 Gene

Proteins for CD53 Gene

  • Protein details for CD53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19397-CD53_HUMAN
    Recommended name:
    Leukocyte surface antigen CD53
    Protein Accession:
    P19397
    Secondary Accessions:
    • B2R905
    • Q5U0D6

    Protein attributes for CD53 Gene

    Size:
    219 amino acids
    Molecular mass:
    24341 Da
    Quaternary structure:
    • Interacts with SCIMP.

neXtProt entry for CD53 Gene

Proteomics data for CD53 Gene at MOPED

Post-translational modifications for CD53 Gene

  • Glycosylation at Asn129 and Asn148

Other Protein References for CD53 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD53 Gene

Domains for CD53 Gene

Gene Families for CD53 Gene

HGNC:
  • CD :CD molecules
  • TSPAN :Tetraspanins

Suggested Antigen Peptide Sequences for CD53 Gene

Graphical View of Domain Structure for InterPro Entry

P19397

UniProtKB/Swiss-Prot:

CD53_HUMAN :
  • P19397
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD53: view

Function for CD53 Gene

Molecular function for CD53 Gene

GENATLAS Biochemistry: cell differentiation antigen 53,32-40kDa,single chain glycoprotein,identified by monoclonal antibodies H129,H136,MEM-53,HD77,see MOX44
UniProtKB/Swiss-Prot Function: Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).

Gene Ontology (GO) - Molecular Function for CD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21930792
genes like me logo Genes that share ontologies with CD53: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CD53 Gene

Localization for CD53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD53 Gene

Cell membrane. Cell junction. Membrane; Multi-pass membrane protein. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD53 Gene COMPARTMENTS Subcellular localization image for CD53 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 21930792
GO:0005886 plasma membrane ISS --
GO:0005911 cell-cell junction ISS --
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD53: view

Pathways for CD53 Gene

SuperPathways for CD53 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CD53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8404042
GO:1901741 positive regulation of myoblast fusion ISS --
genes like me logo Genes that share ontologies with CD53: view

No data available for Pathways by source for CD53 Gene

Transcripts for CD53 Gene

Unigene Clusters for CD53 Gene

CD53 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD53 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - - - - - - -
SP5: - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9:
SP10:

Relevant External Links for CD53 Gene

GeneLoc Exon Structure for
CD53
ECgene alternative splicing isoforms for
CD53

Expression for CD53 Gene

mRNA expression in normal human tissues for CD53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD53 Gene

This gene is overexpressed in Whole Blood (28.6) and Spleen (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD53 Gene

SOURCE GeneReport for Unigene cluster for CD53 Gene Hs.443057

mRNA Expression by UniProt/SwissProt for CD53 Gene

P19397-CD53_HUMAN
Tissue specificity: B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells
genes like me logo Genes that share expressions with CD53: view

Orthologs for CD53 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD53 35
  • 99.85 (n)
  • 100 (a)
CD53 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD53 35
  • 87.52 (n)
  • 87.21 (a)
CD53 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD53 35
  • 87.6 (n)
  • 86.05 (a)
CD53 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd53 35
  • 82.95 (n)
  • 83.11 (a)
Cd53 16
Cd53 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD53 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD53 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd53 35
  • 82.5 (n)
  • 81.28 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496085 35
  • 59.72 (n)
  • 55.56 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
CD53 36
  • 40 (a)
OneToOne
zgc:64051 35
  • 51.9 (n)
  • 41.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp5D 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-8 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for CD53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD53 Gene

ENSEMBL:
Gene Tree for CD53 (if available)
TreeFam:
Gene Tree for CD53 (if available)

Paralogs for CD53 Gene

Paralogs for CD53 Gene

Selected SIMAP similar genes for CD53 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CD53 Gene

genes like me logo Genes that share paralogs with CD53: view

Variants for CD53 Gene

Sequence variations from dbSNP and Humsavar for CD53 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs497759 -- 110,871,128(-) TCAGC(C/T)GGCTA upstream-variant-2KB
rs931547 -- 110,874,824(-) AAAAA(A/C)CCAAG intron-variant
rs976439 -- 110,876,752(-) AATAA(A/G)TGATC intron-variant
rs976440 -- 110,876,684(-) ATTCT(A/T)CAATA intron-variant
rs976441 -- 110,876,651(-) ATGGA(A/G)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD53 Gene

Variant ID Type Subtype PubMed ID
nsv831037 CNV Gain 17160897
dgv330n71 CNV Loss 21882294
nsv522939 CNV Loss 19592680

Relevant External Links for CD53 Gene

HapMap Linkage Disequilibrium report
CD53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD53 Gene

Disorders for CD53 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CD53 Gene including...

Search for CD53 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CD53 Gene

(1) Novoseek inferred disease relationships for CD53 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for CD53

Genetic Association Database (GAD)
CD53
Human Genome Epidemiology (HuGE) Navigator
CD53
genes like me logo Genes that share disorders with CD53: view

No data available for UniProtKB/Swiss-Prot for CD53 Gene

Publications for CD53 Gene

  1. The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens. (PMID: 1700763) Angelisova P. … Horejsi V. (Immunogenetics 1990) 3 4 23
  2. Genomic structure of the human CD53 gene. (PMID: 8319976) KorA-nek V. … HorejsA- V. (Immunogenetics 1993) 2 3 23
  3. Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes. (PMID: 9862348) Nichols T.C. … Holers V.M. (Eur. J. Immunol. 1998) 3 23
  4. Functional expression of transmembrane 4 superfamily molecules on human eosinophils. (PMID: 10529602) Matsumoto K. … Kurashige T. (Int. Arch. Allergy Immunol. 1999) 3 23
  5. Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells. (PMID: 11157846) Engering A. … Pieters J. (Int. Immunol. 2001) 3 23

Products for CD53 Gene

Sources for CD53 Gene

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