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Aliases for CD52 Gene

Aliases for CD52 Gene

  • CD52 Molecule 2 3 5
  • Human Epididymis-Specific Protein 5 3 4
  • CD52 Antigen (CAMPATH-1 Antigen) 2 3
  • Epididymal Secretory Protein E5 3 4
  • Cambridge Pathology 1 Antigen 3 4
  • CDW52 3 4
  • He5 3 4
  • Epididymis Secretory Sperm Binding Protein Li 171mP 3
  • CDW52 Antigen (CAMPATH-1 Antigen) 3
  • CAMPATH-1 Antigen 3
  • CD52 Antigen 4
  • HEL-S-171mP 3
  • EDDM5 3

External Ids for CD52 Gene

Previous HGNC Symbols for CD52 Gene

  • CDW52

Previous GeneCards Identifiers for CD52 Gene

  • GC01P026329
  • GC01P026516
  • GC01P026644
  • GC01P024898

Summaries for CD52 Gene

GeneCards Summary for CD52 Gene

CD52 (CD52 Molecule) is a Protein Coding gene. Diseases associated with CD52 include Chronic Lymphocytic Leukemia and Relapsing-Remitting Multiple Sclerosis. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

UniProtKB/Swiss-Prot for CD52 Gene

  • May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

Additional gene information for CD52 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD52 Gene

Genomics for CD52 Gene

Regulatory Elements for CD52 Gene

Enhancers for CD52 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H026274 2 FANTOM5 Ensembl ENCODE dbSUPER 38.9 -34.0 -34027 19.1 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 HMGN2 ARID1A LOC101928324 CD52 UBXN11 CEP85 GPN2 LIN28A NPM1P39 TRIM63
GH01H026236 1.2 Ensembl ENCODE 28.6 -80.8 -80799 2.2 HDAC1 HDGF NFRKB SIN3A BATF CHAMP1 ZNF366 FOS JUNB ZEB2 CD52 HMGN2 ARID1A LOC101928324 UBXN11 ENSG00000261349 CEP85 RPL17P9 GPN2 ENSG00000236782
GH01H026233 1.1 ENCODE 28.2 -83.3 -83335 2.3 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ARID1A CD52 ZNF593 UBXN11 HMGN2 NPM1P39 LOC101928324 CEP85 LOC101928728 ENSG00000236782
GH01H026313 1.4 FANTOM5 ENCODE 20.2 +0.3 250 8.4 HDGF PKNOX1 ATF1 SIN3A ARID4B BRCA1 ZNF2 ZNF766 GATA2 ZNF143 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ENSG00000236782 ZNF593 FAM110D
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD52 on UCSC Golden Path with GeneCards custom track

Promoters for CD52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for CD52 Gene

Genomic Locations for CD52 Gene
2,604 bases
Plus strand

Genomic View for CD52 Gene

Genes around CD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD52 Gene

Proteins for CD52 Gene

  • Protein details for CD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CAMPATH-1 antigen
    Protein Accession:
    Secondary Accessions:
    • Q5T138
    • Q9BW46

    Protein attributes for CD52 Gene

    61 amino acids
    Molecular mass:
    6614 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CD52 Gene

Post-translational modifications for CD52 Gene

Other Protein References for CD52 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD52 Gene

Domains & Families for CD52 Gene

Gene Families for CD52 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Predicted membrane proteins

Protein Domains for CD52 Gene


Suggested Antigen Peptide Sequences for CD52 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD52: view

No data available for UniProtKB/Swiss-Prot for CD52 Gene

Function for CD52 Gene

Molecular function for CD52 Gene

UniProtKB/Swiss-Prot Function:
May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

Phenotypes From GWAS Catalog for CD52 Gene

genes like me logo Genes that share phenotypes with CD52: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD52 Gene

Localization for CD52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD52 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD52 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1711975
GO:0016020 membrane TAS 1711975
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD52: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD52 Gene

Pathways & Interactions for CD52 Gene

genes like me logo Genes that share pathways with CD52: view

Interacting Proteins for CD52 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000363330 P31358-CD52_HUMAN for CD52 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 8223854
GO:0045730 respiratory burst NAS 8223854
genes like me logo Genes that share ontologies with CD52: view

No data available for SIGNOR curated interactions for CD52 Gene

Drugs & Compounds for CD52 Gene

(7) Drugs for CD52 Gene - From: DrugBank, ClinicalTrials, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alemtuzumab Approved, Investigational Pharma antibody, Target Therapeutic Antibodies 316
Campath Approved May 2001 Pharma 0
Antibodies Pharma 6725
Antibodies, Monoclonal Pharma 4265
Immunoglobulins Pharma 6713

(2) Additional Compounds for CD52 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD52: view

Transcripts for CD52 Gene

mRNA/cDNA for CD52 Gene

Unigene Clusters for CD52 Gene

CD52 molecule:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD52 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -

Relevant External Links for CD52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD52 Gene

This gene is overexpressed in Whole Blood (x16.1) and Spleen (x9.8).

NURSA nuclear receptor signaling pathways regulating expression of CD52 Gene:


SOURCE GeneReport for Unigene cluster for CD52 Gene:


Evidence on tissue expression from TISSUES for CD52 Gene

  • Spleen(4.6)
  • Blood(3.6)
  • Lymph node(3.2)
  • Bone marrow(3.1)
  • Intestine(2.6)
  • Lung(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with CD52: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD52 Gene

Orthologs for CD52 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CD52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD52 33 34
  • 99.45 (n)
Species where no ortholog for CD52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD52 Gene

Gene Tree for CD52 (if available)
Gene Tree for CD52 (if available)

Paralogs for CD52 Gene

(1) SIMAP similar genes for CD52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD52: view

No data available for Paralogs for CD52 Gene

Variants for CD52 Gene

Sequence variations from dbSNP and Humsavar for CD52 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002242524 -- 26,316,375(+) ACCTA(C/G)CATGT intron-variant, upstream-variant-2KB
rs1002944347 -- 26,317,123(+) GTAGT(C/G)CCAGC intron-variant, upstream-variant-2KB
rs1002994005 -- 26,317,349(+) GGAAA(C/G)CCCAA intron-variant, upstream-variant-2KB
rs1003278228 -- 26,318,487(+) GTTAT(C/G)GAGGT intron-variant, upstream-variant-2KB
rs1004241996 -- 26,319,818(+) AAACA(C/T)GCTAT intron-variant, upstream-variant-2KB

Variation tolerance for CD52 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD52 Gene

Disorders for CD52 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CD52 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • b-cell chronic lymphocytic leukemia
relapsing-remitting multiple sclerosis
  • relapsing-remitting ms
lymphoma, non-hodgkin
  • lymphoma, non-hodgkin, somatic
t-cell prolymphocytic leukemia
  • leukemia, t-cell, chronic
aplastic anemia
  • pulmonary fibrosis, idiopathic
- elite association - COSMIC cancer census association via MalaCards
Search CD52 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD52

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CD52: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD52 Gene

Publications for CD52 Gene

  1. Changes of the major sperm maturation-associated epididymal protein HE5 (CD52) on human ejaculated spermatozoa during incubation. (PMID: 11420384) Yeung CH … Cooper TG (Molecular human reproduction 2001) 2 3 22 60
  2. A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone. (PMID: 8418821) Kirchhoff C … Ivell R (Molecular reproduction and development 1993) 3 4 22 60
  3. Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone. (PMID: 1711975) Xia MQ … Waldmann H (European journal of immunology 1991) 2 3 4 60
  4. The GPI-anchored CD52 antigen of the sperm surface interacts with semenogelin and participates in clot formation and liquefaction of human semen. (PMID: 17624925) Flori F … Giovampaola CD (Molecular reproduction and development 2008) 3 22 60
  5. Different levels of CD52 antigen expression evaluated by quantitative fluorescence cytometry are detected on B-lymphocytes, CD 34+ cells and tumor cells of patients with chronic B-cell lymphoproliferative diseases. (PMID: 17428002) Klabusay M … Mayer J (Cytometry. Part B, Clinical cytometry 2007) 3 22 60

Products for CD52 Gene

Sources for CD52 Gene

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