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Aliases for CD52 Gene

Aliases for CD52 Gene

  • CD52 Molecule 2 3
  • CDW52 3 4 6
  • Human Epididymis-Specific Protein 5 3 4
  • CD52 Antigen (CAMPATH-1 Antigen) 2 3
  • Epididymal Secretory Protein E5 3 4
  • Cambridge Pathology 1 Antigen 3 4
  • He5 3 4
  • Epididymis Secretory Sperm Binding Protein Li 171mP 3
  • CDW52 Antigen (CAMPATH-1 Antigen) 3
  • CAMPATH-1 Antigen 3
  • CD52 Antigen 4
  • HEL-S-171mP 3

External Ids for CD52 Gene

Previous Symbols for CD52 Gene

  • CDW52

Summaries for CD52 Gene

GeneCards Summary for CD52 Gene

CD52 (CD52 Molecule) is a Protein Coding gene. Diseases associated with CD52 include chronic lymphocytic leukemia and aplastic anemia.

UniProtKB/Swiss-Prot for CD52 Gene

  • May play a role in carrying and orienting carbohydrate, as well as having a more specific role

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD52 Gene

Genomics for CD52 Gene

Genomic Location for CD52 Gene

Start:
26,317,920 bp from pter
End:
26,320,523 bp from pter
Size:
2,604 bases
Orientation:
Plus strand

Genomic View for CD52 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD52 Gene

Regulatory Elements for CD52 Gene

Proteins for CD52 Gene

  • Protein details for CD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31358-CD52_HUMAN
    Recommended name:
    CAMPATH-1 antigen
    Protein Accession:
    P31358
    Secondary Accessions:
    • Q5T138
    • Q9BW46

    Protein attributes for CD52 Gene

    Size:
    61 amino acids
    Molecular mass:
    6614 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CD52 Gene

Proteomics data for CD52 Gene at MOPED

Post-translational modifications for CD52 Gene

Other Protein References for CD52 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD52 Gene

Domains for CD52 Gene

Gene Families for CD52 Gene

HGNC:
  • CD :CD molecules

Protein Domains for CD52 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CD52: view

No data available for UniProtKB/Swiss-Prot for CD52 Gene

Function for CD52 Gene

Molecular function for CD52 Gene

UniProtKB/Swiss-Prot Function: May play a role in carrying and orienting carbohydrate, as well as having a more specific role

Phenotypes for CD52 Gene

genes like me logo Genes that share phenotypes with CD52: view

Animal Models for CD52 Gene

MGI Knock Outs for CD52:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for CD52 Gene

Localization for CD52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD52 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD52 Gene COMPARTMENTS Subcellular localization image for CD52 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 1711975
GO:0016020 membrane TAS 1711975
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CD52: view

Pathways for CD52 Gene

SuperPathways for CD52 Gene

No Data Available

Interacting Proteins for CD52 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000363330%0d%0a9606.ENSP00000254436%0d%0a
Selected Interacting proteins: ENSP00000363330 for CD52 Gene via STRING

Symbol External ID(s) Details
TRIM21

Gene Ontology (GO) - Biological Process for CD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 8223854
GO:0045730 respiratory burst NAS 8223854
genes like me logo Genes that share ontologies with CD52: view

No data available for Pathways by source for CD52 Gene

Compounds for CD52 Gene

(1) Drugbank Compounds for CD52 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alemtuzumab
216503-57-0 target antibody

(5) Novoseek inferred chemical compound relationships for CD52 Gene

Compound -log(P) Hits PubMed IDs
alemtuzumab 95.3 42
fludarabine 68.4 1
rituximab 63 4
sialic acid 15.5 1
polysaccharide 0 1
genes like me logo Genes that share compounds with CD52: view

Transcripts for CD52 Gene

mRNA/cDNA for CD52 Gene

Unigene Clusters for CD52 Gene

CD52 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD52 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -
SP3:

Relevant External Links for CD52 Gene

GeneLoc Exon Structure for
CD52
ECgene alternative splicing isoforms for
CD52

Expression for CD52 Gene

mRNA expression in normal human tissues for CD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD52 Gene

This gene is overexpressed in Whole Blood (16.1) and Spleen (9.8).

SOURCE GeneReport for Unigene cluster for CD52 Gene Hs.276770

genes like me logo Genes that share expressions with CD52: view

Orthologs for CD52 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for CD52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD52 36
  • 99.45 (n)
  • 98.36 (a)
CD52 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd52 16
Species with no ortholog for CD52:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD52 Gene

ENSEMBL:
Gene Tree for CD52 (if available)
TreeFam:
Gene Tree for CD52 (if available)

Paralogs for CD52 Gene

Selected SIMAP similar genes for CD52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD52: view

No data available for Paralogs for CD52 Gene

Variants for CD52 Gene

Sequence variations from dbSNP and Humsavar for CD52 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs41285429 -- 26,320,292(+) CTTCT(A/G)CTTCA missense, reference
rs113945811 -- 26,320,524(+) TTGCA(A/G)TGGGG splice-donor-variant
rs115642626 -- 26,320,531(+) GGGGT(C/G)CTGCT downstream-variant-500B
rs116480682 -- 26,320,420(+) AGAAG(C/T)TGACA utr-variant-3-prime
rs141375493 -- 26,320,830(+) CCCTA(C/T)CCCAC downstream-variant-500B

Relevant External Links for CD52 Gene

HapMap Linkage Disequilibrium report
CD52

No data available for Structural Variations from Database of Genomic Variants (DGV) for CD52 Gene

Disorders for CD52 Gene

(3) University of Copenhagen DISEASES for CD52 Gene

(11) Novoseek inferred disease relationships for CD52 Gene

Disease -log(P) Hits PubMed IDs
cll refractory 73.4 1
leukemia lymphocytic chronic 68.2 4
lymphoproliferative disorders 57.3 4
leukaemia lymphocytic 50.7 2
lymphoma t-cell 39.7 1

Relevant External Links for CD52

Human Genome Epidemiology (HuGE) Navigator
CD52
genes like me logo Genes that share disorders with CD52: view

No data available for UniProtKB/Swiss-Prot for CD52 Gene

Publications for CD52 Gene

  1. A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone. (PMID: 8418821) Kirchhoff C. … Ivell R. (Mol. Reprod. Dev. 1993) 3 4 23
  2. Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone. (PMID: 1711975) Xia M.-Q. … Waldmann H. (Eur. J. Immunol. 1991) 2 3 4
  3. Region-specific variation of gene expression in the human epididymis as revealed by in situ hybridization with tissue-specific cDNAs. (PMID: 8418812) Krull N. … Kirchhoff C. (Mol. Reprod. Dev. 1993) 3 23
  4. Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol- anchored glycoprotein which is an exceptionally good target for complement lysis. (PMID: 7688956) Xia M.Q. … Waldmann H. (Biochem. J. 1993) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CD52 Gene

Sources for CD52 Gene

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