CD5 Gene

Aliases
for CD5 gene

Previous GC identifers: GC11P063262 GC11P062382 GC11P061120 GC11P060646 GC11P060647 GC11P060626 GC11P057229

Summaries
for CD5 gene

Genomic Views
for CD5 gene

RefSeq DNA sequence:

NC_000011.9  NC_018922.1  NT_167190.1  

SwitchGear Promoter luciferase reporter plasmid: CD5 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD5

CD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060869:  view genomic region     (about GC identifiers)

Proteins
for CD5 gene

4 PDB 3D structures from and Proteopedia for CD5:

2JA4 (3D)        2JOP (3D)        2JP0 (3D)        2OTT (3D)    

Explore the universe of human proteins at neXtProt for CD5: NX_P06127

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD5
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CD5 OriGene Protein Over-expression Lysate: CD5 OriGene Custom Protein Services for CD5
	GenScript Custom Purified and Recombinant Proteins Services for CD5
	Novus Biologicals CD5 Proteins Novus Biologicals CD5 Lysate
	Sino Biological Recombinant Protein for CD5
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD5

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD5
	R&D Systems Antibodies for CD5
	OriGene Antibodies (see all 8): CD5 OriGene Custom Antibody Services for CD5
	GenScript Superior Antibodies for CD5
	Novus Biologicals CD5 Antibodies
	Abcam antibodies for CD5
	Uscn Antibodies for CD5
	ThermoFisher Antibody for CD5

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CD5
	GenScript Custom Assay Services for CD5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD5

Protein Domains /
Families
for CD5 gene

ProtoNet protein and cluster: P06127

Function
for CD5 gene

miRNA Products:		OriGene 3'-UTR Clone: CD5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD5
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CD5 (see all 13):
		hsa-miR-345 hsa-miR-631 hsa-miR-520d-5p hsa-miR-516b* hsa-miR-3661 hsa-miR-211 hsa-miR-3922-3p hsa-miR-1276
		SwitchGear 3'UTR luciferase reporter plasmid: CD5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD5 (see all 7) OriGene shRNA RFP: CD5 OriGene siRNA: CD5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD5

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD5 (NM_014207)
		Sino Biological Human cDNA Clone for CD5
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD5
		Search LifeMap BioReagents cell lines for CD5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD5

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Cd5)

Pathways & Interactions
for CD5 gene

	Super-pathway	contained gene-specific pathways
1	B Cell Receptor Signaling Pathway	B Cell Receptor Signaling Pathway 1.00
2	Hematopoietic cell lineage	Hematopoietic cell lineage 1.00

1 BioSystems Pathway for CD5

B Cell Receptor Signaling Pathway

1         Kegg Pathway  (Kegg details for CD5)

Hematopoietic cell lineage

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CD5 gene

Transcripts
for CD5 gene

Expression
for CD5 gene

CD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAACACATC

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BloodPeripheral BloodT-Cytotoxic Cells			Blood
	BloodPeripheral BloodT-Helper Cells			Blood
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD5

Orthologs
for CD5 gene

Paralogs
for CD5 gene

Genomic Variants
for CD5 gene

10/531 NCBI SNPs in CD5 are shown (see all 531)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1888651121,2		--	60868011(+)	CACACA/CCATAA	1	--	us2k1		0	--	--	--	--
rs1926005081,2		--	60868015(+)	CACATA/CAACAT	1	--	us2k1		0	--	--	--	--
rs1845838701,2		--	60868052(+)	GAGATC/TACACA	1	--	us2k1		0	--	--	--	--
rs1429306471,2	C,	--	60868074(+)	GAGAT-/CACACAC	1	--	us2k1		0	--	--	--	--
rs2001509221,2		--	60868606(+)	ATCAA-/CATGGA	1	--	us2k1		0	--	--	--	--
rs1881988331,2		--	60868650(+)	TCATCA/CACATG	1	--	us2k1		0	--	--	--	--
rs1820310831,2	C	--	60868843(+)	CACACA/GCACAT	1	--	us2k1		0	--	--	--	--
rs1806827241,2		--	60868861(+)	GAGATC/TACACA	1	--	us2k1		0	--	--	--	--
rs1444122381,2		--	60869144(+)	CACATC/TAACAT	1	--	us2k1		0	--	--	--	--
rs626364191,2	C,	--	60869222(+)	GAGATT/CACACA	1	--	us2k1		3		WA NA EA	242

HapMap Linkage Disequilibrium report for CD5 (60869867 - 60895324 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD5
     1 CNV: 4747
Human Gene Mutation Database (HGMD): CD5

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD5

DNA2.0 Custom Variant and Variant Library Synthesis for CD5

Disorders / Diseases
for CD5 gene

20/49 diseases for CD5

10/28 Novoseek disease relationships for CD5 gene (see all 28)    About this table

Publications
for CD5 gene

PubMed articles for CD5 gene, integrated from 9 sources (see all 200): (articles sorted by number of sources associating them with CD5)

Utopia: connect your pdf to the dynamic world of online information

1. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PubMed id 1711157)^{1, 2, 3} van de Velde H.... Thielemans K. (1991)
2. Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5. (PubMed id 18339402)^{1, 2} Garza-Garcia A....Driscoll P.C. (2008)
3. Polymorphism in the CD5 gene promoter in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. (PubMed id 15981803)^{1, 4} Perez-Chacon G....Perez-Aciego P. (2005)
4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)^{1, 2} Salomon A.R.... Peters E.C. (2003)
7. Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1. (PubMed id 3093892)^{1, 2} Jones N.H....Strominger J.L. (1986)
8. An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes. (PubMed id 15998834)^{1, 9} Renaudineau Y.... Youinou P. (2005)
9. CD5 does not regulate the signaling triggered through BCR in B cells from a subset of B-CLL patients. (PubMed id 17325858)^{1, 9} Perez-Chacon G....Perez-Aciego P. (2007)
10. Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases. (PubMed id 11298344)^{1, 9} Vila J.M....Lozano F. (2001)

External Searches for CD5 gene

Genome Databases showing CD5 gene

Other Databases showing CD5 gene

Specialized Databases showing CD5 gene

Products
for CD5 gene