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CD5 Gene

protein-coding   GIFtS: 65
GCID: GC11P060869

CD5 Molecule

(Previous name: CD5 antigen (p56-62))
(Previous symbol: LEU1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD5 Molecule1 2     T12
LEU11 2 3 5     T-Cell Surface Glycoprotein CD52
CD5 Antigen (P56-62)1 2     CD5 Antigen3
Lymphocyte Antigen T1/Leu-12 3     

External Ids:    HGNC: 16851   Entrez Gene: 9212   Ensembl: ENSG000001104487   OMIM: 1533405   UniProtKB: P061273   

Export aliases for CD5 gene to outside databases

Previous GC identifers: GC11P063262 GC11P062382 GC11P061120 GC11P060646 GC11P060647 GC11P060626 GC11P057229


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CD5 Gene:
CD5 (CD5 molecule) is a protein-coding gene. Diseases associated with CD5 include thymic epithelial tumor, and type ii mixed cryoglobulinemia. GO annotations related to this gene include scavenger receptor activity and receptor activity.

UniProtKB/Swiss-Prot: CD5_HUMAN, P06127
Function: May act as a receptor in regulating T-cell proliferation

Gene Wiki entry for CD5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD5 gene promoter:
         Max1   USF1   SREBP-1c   FOXD1   POU3F2   SREBP-1b   USF-1   c-Myb   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD5 promoter sequence
   Search Chromatin IP Primers for CD5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q13

CD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060869:  view genomic region     (about GC identifiers)

Start:
60,869,867 bp from pter      End:
60,895,324 bp from pter
Size:
25,458 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD5_HUMAN, P06127 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD5 precursor  
Size: 495 amino acids; 54578 Da
Subunit: Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1 (By similarity)
4 PDB 3D structures from and Proteopedia for CD5:
2JA4 (3D)        2JOP (3D)        2JP0 (3D)        2OTT (3D)    
Secondary accessions: A0N0P4 A8K9I3

Explore the universe of human proteins at neXtProt for CD5: NX_P06127

Explore proteomics data for CD5 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1 (By similarity)1
  • Ubiquitination2 at Lys43, Lys273, Lys346
  • Glycosylation2 at Asn116, Asn241
  • Modification sites at PhosphoSitePlus

  • See CD5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055022.2  
    ENSEMBL proteins: 
     ENSP00000342681   ENSP00000440899  

    CD5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD5
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD5
    OriGene Protein Over-expression Lysate for CD5
    OriGene MassSpec for CD5
    OriGene Custom Protein Services for CD5
    GenScript Custom Purified and Recombinant Proteins Services for CD5
    Novus Biologicals CD5 Proteins
    Novus Biologicals CD5 Lysate
    Sino Biological Recombinant Protein for CD5
    Sino Biological Cell Lysate for CD5
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD5

    CD5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD5
    R&D Systems Antibodies for CD5
    OriGene Antibodies for CD5
    OriGene Custom Antibody Services for CD5
    Novus Biologicals CD5 Antibodies
    Abcam antibodies for CD5
    Cloud-Clone Corp. Antibodies for CD5
    ThermoFisher Antibody for CD5
    LSBio Antibodies in human, mouse, rat for CD5

    CD5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD5
    R&D Systems Proteome Profiler Antibody Arrays for CD5
    GenScript Custom Assay Services for CD5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD5
    Cloud-Clone Corp. CLIAs for CD5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    3 InterPro protein domains:
     IPR001190 SRCR
     IPR003566 Tcell_CD5
     IPR017448 Srcr_rcpt-rel

    Graphical View of Domain Structure for InterPro Entry P06127

    ProtoNet protein and cluster: P06127

    2 Blocks protein domains:
    IPB001190 Speract/scavenger receptor
    IPB003566 T-cell surface glycoprotein CD5 signature


    UniProtKB/Swiss-Prot: CD5_HUMAN, P06127
    Similarity: Contains 3 SRCR domains


    CD5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD5_HUMAN, P06127
    Function: May act as a receptor in regulating T-cell proliferation

         Genatlas biochemistry entry for CD5:
    cell differentiation antigen CD5 (p56-62),expressed on thymocytes,T and B cells,single chain,identified by
    monoclonal antibodies T1,UCHT2,T101,HH9,AMG4

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS1711157
    GO:0004888transmembrane signaling receptor activity NAS3093892
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding IPI1711157
         
    CD5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD5:
     Decreased Wnt reporter activit 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd5):
     hematopoietic system  immune system  no phenotypic analysis  normal 

    CD5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd5tm1Cgn for CD5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CD5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD5 (see all 13):
    hsa-miR-345 hsa-miR-631 hsa-miR-520d-5p hsa-miR-516b* hsa-miR-3661 hsa-miR-211 hsa-miR-3922-3p hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidCD5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD5
    Predesigned siRNA for gene silencing in human, mouse, rat CD5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD5

    Clone
    Products:
         
    OriGene clones in human, mouse for CD5 (see all 6)
    OriGene ORF clones in mouse, rat for CD5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD5 (NM_014207)
    Sino Biological Human cDNA Clone for CD5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD5
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD5_HUMAN, P06127: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA11390434
    GO:0005887integral component of plasma membrane NAS1711157
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----

    CD5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD5 About    
    See pathways by source

    SuperPathContained pathways About
    1Hematopoietic cell lineage
    Hematopoietic cell lineage
    2B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CD5
        B Cell Receptor Signaling Pathway



    1 Kegg Pathway  (Kegg details for CD5):
        Hematopoietic cell lineage


    CD5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD5: 
              Cell Surface Markers in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis 384HT in human mouse rat
              Antifungal Response in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for CD5 (P061272, 3 ENSP000003426814) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8034694 MINT-8034710 I2D: score=3 STRING: ENSP00000274335
    RASA1P209362, 3, ENSP000002743764MINT-8037472 I2D: score=4 STRING: ENSP00000274376
    CD2P067293, ENSP000003584904I2D: score=3 STRING: ENSP00000358490
    CD6P302033, ENSP000003232804I2D: score=3 STRING: ENSP00000323280
    ZAP70P434033, ENSP000002649724I2D: score=3 STRING: ENSP00000264972
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008037cell recognition NAS1711157
    GO:0008283cell proliferation NAS3093892
    GO:0031295T cell costimulation IEA--
    GO:0097190apoptotic signaling pathway IEA--

    CD5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD5

    5 Novoseek inferred chemical compound relationships for CD5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gelonin 69.6 2 7541032 (1), 8659923 (1)
    ricin 51.7 1 1722193 (1)
    paraffin 18.9 4 9615189 (3), 12890804 (1)
    calcium 0 1 10540344 (1)
    tyrosine 0 8 11298344 (4), 8898942 (1), 17325858 (1), 10540344 (1)



    CD5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CD5 gene: 
    NM_014207.3  

    Unigene Cluster for CD5:

    CD5 molecule
    Hs.58685  [show with all ESTs]
    Unigene Representative Sequence: NM_014207
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347785(uc009ynk.3) ENST00000544014
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD5 (see all 13):
    hsa-miR-345 hsa-miR-631 hsa-miR-520d-5p hsa-miR-516b* hsa-miR-3661 hsa-miR-211 hsa-miR-3922-3p hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidCD5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD5
    Predesigned siRNA for gene silencing in human, mouse, rat CD5
    Clone
    Products:
         
    OriGene clones in human, mouse for CD5 (see all 6)
    OriGene ORF clones in mouse, rat for CD5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD5 (NM_014207)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD5
    OriGene qSTAR qPCR primer pairs in human, mouse for CD5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD5
      QuantiTect SYBR Green Assays in human, mouse, rat CD5
      QuantiFast Probe-based Assays in human, mouse, rat CD5

    Additional mRNA sequence: 

    AK292698.1 AY541703.1 BC027901.1 X04391.1 

    3 DOTS entries:

    DT.412598  DT.120716096  DT.120716185 

    Selected AceView cDNA sequences (see all 56):

    AA309891 AY541703 BX107940 AI670004 F26511 BM704160 AL557643 AI650591 
    CD625268 BC027901 AI797836 BI909143 CD625275 AA311437 CD625269 CD625261 
    BQ711839 AA309449 CD625273 CD625272 BM550047 BQ881887 CD625264 AW594651 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACACATC
    CD5 Expression
    About this image


    CD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             T-Cytotoxic Cells Peripheral Blood
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Heart (Cardiovascular System)
    CD5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.58685
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD5: 
              Cell Surface Markers in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis 384HT in human mouse rat
              Antifungal Response in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD5
    OriGene qSTAR qPCR primer pairs in human, mouse for CD5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD5
    QuantiTect SYBR Green Assays in human, mouse, rat CD5
    QuantiFast Probe-based Assays in human, mouse, rat CD5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD5 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd51 , 5 CD5 antigen1, 5 73.53(n)1
    64.61(a)1
      19 (7.16 cM)5
    125071  NM_007650.31  NP_031676.31 
     107181435 
    chicken
    (Gallus gallus)
    Aves CD51 CD5 molecule 52.35(n)
    42.26(a)
      395757  NM_204921.1  NP_990252.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD56
    CD5 molecule
    31(a)
    1 ↔ 1
    GL343235.1(641054-666069)


    ENSEMBL Gene Tree for CD5 (if available)
    TreeFam Gene Tree for CD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD5 (see all 690)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888651121,2
    --60868011(+) CACACA/CCATAA 1 -- us2k10--------
    rs1926005081,2
    --60868015(+) CACATA/CAACAT 1 -- us2k10--------
    rs1845838701,2
    --60868052(+) GAGATC/TACACA 1 -- us2k10--------
    rs2005760571,2
    C--60868149(+) ACATTC/TACACA 1 -- us2k10--------
    rs2001509221,2
    C--60868606(+) CATCA-/CATGGA 1 -- us2k10--------
    rs1881988331,2
    --60868650(+) TCATCA/CACATG 1 -- us2k10--------
    rs1820310831,2
    C--60868843(+) CACACA/GCACAT 1 -- us2k10--------
    rs1806827241,2
    --60868861(+) GAGATC/TACACA 1 -- us2k10--------
    rs2017884171,2
    C--60868871(+) ACACA-/CGTCAAC 1 -- us2k10--------
    rs3690287441,2
    C--60868923(+) TTCAC-/CACACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD5 (60869867 - 60895324 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509412CNV Insertion20534489
    nsv526162CNV Loss19592680
    nsv897602CNV Loss21882294
    nsv428259CNV Gain+Loss18775914
    nsv832176CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): CD5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD5
    DNA2.0 Custom Variant and Variant Library Synthesis for CD5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153340    OMIM disorders: --

    Selected diseases for CD5 (see all 58):    
    About MalaCards
    thymic epithelial tumor    type ii mixed cryoglobulinemia    thymic carcinoma    secondary progressive multiple sclerosis
    richter's syndrome    lymphoplasmacytoid lymphoma    lymphatic system disease    cryoglobulinemia
    b cell prolymphocytic leukemia    prolymphocytic leukemia    t-cell prolymphocytic leukemia    intravascular large b-cell lymphoma
    lymphoid leukemia    mantle cell lymphoma    systemic mastocytosis    splenic marginal zone lymphoma
    malt lymphoma    diffuse large b-cell lymphoma    marginal zone b-cell lymphoma    thymoma

    9 diseases from the University of Copenhagen DISEASES database for CD5:
    Lymphoma     Leukemia     Thymic carcinoma     Hypersensitivity reaction type II disease
    Macroglobulinemia     Thymoma     Anemia     Rheumatoid arthritis
    Cryoglobulinemia

    CD5 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CD5 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma small lymphocytic 76.3 6 9043774 (1), 9796727 (1), 1370753 (1), 17430665 (1)
    lymphocytic leukemia chronic b-cell 75.3 8 7513207 (2), 1694698 (1), 8042591 (1), 1694132 (1) (see all 7)
    leukemia lymphocytic chronic 74.3 13 1694698 (1), 9043774 (1), 9796727 (1), 9720730 (1) (see all 10)
    leukemia prolymphocytic 70.3 1 20134145 (1)
    leukaemia lymphocytic 69.2 7 1379132 (1), 7543349 (1), 17325858 (1), 16505276 (1) (see all 7)
    lymphoma lymphocytic 61 1 1370753 (1)
    lymphoproliferative disorders 60.7 4 8457472 (1), 17325858 (1), 18497318 (1)
    lymphoma 58.8 11 17430665 (2), 9615189 (2), 9176388 (1), 15629830 (1) (see all 6)
    lymphoma b-cell 58.5 8 9796727 (2), 8561085 (1), 19279536 (1), 8724541 (1)
    lymphoma follicular 57.5 1 12375647 (1)

    Genetic Association Database (GAD): CD5
    Human Genome Epidemiology (HuGE) Navigator: CD5 (9 documents)

    Export disorders for CD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD5 gene, integrated from 10 sources (see all 204):
    (articles sorted by number of sources associating them with CD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PubMed id 1711157)1, 2, 3 van de Velde H.... Thielemans K. (Nature 1991)
    2. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    4. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    5. Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5. (PubMed id 18339402)1, 2 Garza-Garcia A.... Driscoll P.C. (J. Mol. Biol. 2008)
    6. Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis. (PubMed id 18006695)1, 4 Sellick G.S....Houlston R.S. (Blood 2008)
    7. Polymorphism in the CD5 gene promoter in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. (PubMed id 15981803)1, 4 PAcrez-ChacA^n G....PAcrez-Aciego P. (Am. J. Clin. Pathol. 2005)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)1, 2 Salomon A.R.... Peters E.C. (Proc. Natl. Acad. Sci. U.S.A. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 921 HGNC: 1685 AceView: CD5 Ensembl:ENSG00000110448 euGenes: HUgn921
    ECgene: CD5 Kegg: 921 H-InvDB: CD5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD5 gene:
    Search GeneIP for patents involving CD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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