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CD5 Gene

protein-coding   GIFtS: 63

GC11P060626
CD5 molecule
(Previous name: CD5 antigen (p56-62) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LEU1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
LEU1 2, 3, 5
T1 1, 2
Descriptions
CD5 antigen 3
CD5 antigen (p56-62) 1, 2
CD5 molecule 2
Lymphocyte antigen T1/Leu-1 3
External Ids
HGNC: 16851
Entrez Gene: 9212
UniProtKB: P061273
Ensembl: ENSG000001104487
Search outside databases for aliases for CD5 gene

Previous GC identifers: GC11P063262 GC11P062382 GC11P061120 GC11P060646 GC11P060647

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CD5_HUMAN, P06127
Function: May act as a receptor in regulating T-cell proliferation. CD5 interacts with CD72/LYB-2

Gene Wiki entry for CD5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CD5 gene  

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q13

CD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060626:     (about GC identifiers)

Start:
60,626,543 bp from pter
End:
60,651,900 bp from pter
Size:
25,358 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000011.8  NT_033903.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CD5_HUMAN, P06127 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD5 precursor  
Size: 495 amino acids; 54625 Da
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :
2JA4 (3D)    2JOP (3D)    2JP0 (3D)    2OTT (3D)    
Secondary accessions: A0N0P4

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055022.2  

    ENSEMBL proteins: 
    ENSP00000342681 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (CD23 + CD5, CD5 + CD20, CD5 + CD19, CD79a + CD5, CD5)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IDA11390434
    GO:0005887 integral to plasma membrane NAS1711157
    GO:0009897 external side of plasma membrane IEA--
    About this table

    Antibodies for CD5: 
    Invitrogen Antibodies for CD5
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    R&D Systems Antibodies for CD5
    Antibodies from Abcam (CD23 + CD5, CD5 + CD20, CD5 + CD19, CD79a + CD5, CD5), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (CD5)
    Novus Biologicals Antibodies for CD5

    Assays for CD5: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR001190 Srcr_rcpt
     IPR003566 Tcell_CD5
     IPR017448 Srcr_rcpt-rel


       GeneDecks  CD5 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P06127

    ProtoNet protein and cluster: P06127

    2 Blocks protein families:
    IPB001190 Speract/scavenger receptor
    IPB003566 T-cell surface glycoprotein CD5 signature


    UniProtKB/Swiss-Prot: CD5_HUMAN, P06127
    Similarity: Contains 3 SRCR domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (CD5)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CD5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014207

                  Applied Biosystems Silencer® siRNAs for CD5

                  Sigma-Aldrich siRNA and siRNA Panels for CD5  
                         Sigma-Aldrich shRNA Panels and shRNA for CD5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014207
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014207
                                     untagged cDNA clone in CMV expression vector: NM_014207 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_014207

    UniProtKB/Swiss-Prot: CD5_HUMAN, P06127
    Function: May act as a receptor in regulating T-cell proliferation. CD5 interacts with CD72/LYB-2

    Genatlas biochemistry entry for CD5:
    cell differentiation antigen CD5 (p56-62),expressed on thymocytes,T and B cells,single
    chain,identified by monoclonal antibodies T1,UCHT2,T101,HH9,AMG4

    3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd5):

    hematopoietic systemimmune systemnormal

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044 scavenger receptor activity IEA--
    GO:0005515 protein binding IPI1711157
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Kegg Pathway  (Kegg details for CD5):
     hsa04640 Hematopoietic cell lineage

       GeneDecks  CD5 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  CD5 


    5/82 Interacting proteins for CD5 (ENSP000003426813) via UniProtKB, MINT, and/or STRING (see all 82 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCKENSP000003282133STRING (score=.994)
    CD72ENSP000002596333STRING (score=.993)
    CD69ENSP000002284343STRING (score=.967)
    CD40ENSP000002790613STRING (score=.966)
    IL4ENSP000002314493STRING (score=.946)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008037 cell recognition NAS1711157
    GO:0008283 cell proliferation NAS3093892
    GO:0008624 induction of apoptosis by extracellular signals IEA--
    GO:0031295 T cell costimulation IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for CD5
    3 Novoseek chemical compound relationships for CD5 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    ricin 52.84 1 1722193 (1)
    calcium 0.00 1 10540344 (1)
    tyrosine 0.00 8 11298344 (4), 8898942 (1), 17325858 (1), 10540344 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (CD5)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CD5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014207

                  Sigma-Aldrich siRNA and siRNA Panels for CD5  
                         Sigma-Aldrich shRNA Panels and shRNA for CD5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_014207  

    REFSEQ mRNAs for CD5 gene: 

    NM_014207.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_014207  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014207
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014207
                                     untagged cDNA clone in CMV expression vector: NM_014207 

    Additional cDNA sequence: 

    AK292698.1 AY541703.1 BC027901.1 X04391.1 

    3 DOTS entries:

    DT.412598  DT.120716096  DT.120716185 

    24/56 AceView cDNA sequences (see all 56 ):

    F26511 AY541703 AA309891 BM704160 BX107940 AI670004 CD625271 AW594651 
    AA235742 AA311437 CD625265 CD625275 CD625267 AL557643 X04391 AA406028 
    CD625261 BM550047 AA406027 BQ881887 AA309449 BC027901 CD625264 AI650591 

    highest scoring ESTs for CD5:

    AI797836 X04391 AA024392 AA025269 AA235742 AA309891 AA310062 AA311437 AA354313 AA406027 

    Unigene Cluster for CD5:

    CD5 molecule
    Hs.58685  [show with all ESTs]
    Unigene Representative Sequence: NM_014207


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000347785  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CD5 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for CD5

    1 / 2 / 3

    6 probe-sets matching CD5 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    32953_at2, 3 U95-A 1 1.00 1.00 0.96 0.81 X04391 1.00 1.00 1.00 1
    89666_at2, 3 U95-E 1 1.00 1.00 0.98 1.19 AI797836 1.00 1.00 1.00 1

    230489_at2, 3 U133-B 1 1.00 1.00 -- -- AI797836 1.00 1.00 1.00 1

    206485_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014207 0.60 1.00 0.82 1

    230489_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    206485_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  CD5 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGAACACATC

    SOURCE GeneReport for Unigene cluster: Hs.58685

    Expression variation in blood from EXPOLDB for CD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for CD5 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    CD51   -- CD5 molecule 78.35(n)
    69.48(a)
    612338  XM_850074.1  XP_855167.1 
    chimpanzee
    (Pan troglodytes)
    CD51   -- CD5 molecule 99.64(n)
    99.35(a)
    737721  XM_001138219.1  XP_001138219.1 
    cow
    (Bos taurus)
    CD51   -- CD5 molecule 74.9(n)
    64.49(a)
    280745  NM_173899.2  NP_776324.1 
    rat
    (Rattus norvegicus)
    Cd51   -- Cd5 molecule 73.55(n)
    63.64(a)
    54236  NM_019295.1  NP_062168.1 
    mouse
    (Mus musculus)
    Cd51, 5 19 (5.00 cM)5
    CD5 antigen1, 5 73.39(n)1
    64.2(a)1
    125071  NM_007650.31  NP_031676.31 
     AI5286195  AK0421055  (see all 11)
    About this table        Species with no ortholog for CD5

    ENSEMBL Gene Tree for CD5
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/148 NCBI SNPs in CD5 are shown (see all 148 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 85)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs6371861,2
    A,C,F,H,O60649182(+) CTCCCG/ACCTGT 1 R/H mis113Minor allele frequency- A:0.05MN NA EU EA WA 1238
    rs71043331,2
    A,C,F,H60652109(+) CTGCCA/GTGACC 1 -- ng314Minor allele frequency- G:0.24EU EA WA 390
    rs71052361,2
    A,C,F,H60652102(+) GGACGT/CGCTGC 1 -- ng314Minor allele frequency- C:0.26EU EA WA 380
    rs5462411,2
    A,C,F,H60626188(+) TCCCCG/ACCCAG 1 -- ng515Minor allele frequency- A:0.02EA EU WA 1916
    rs122946071,2
    C,F,H60652207(+) CATTCC/TGTAAA 1 -- ng314Minor allele frequency- T:0.07EU EA WA 416
    rs22410021,2
    C,F,H60643489(+) AGACCC/TAGGGG 1 P/L mis1 ese36Minor allele frequency- T:0.07EA EU WA NA 1964
    rs21864091,2
    A,C,F60651068(-) TGTGCA/CGGGCC 1 -- ut31 ese33Minor allele frequency- C:0.16NA 118
    rs22291771,2
    C,F,H60649811(+) AGGGGT/CTCTGC 1 V/A mis116Minor allele frequency- C:0.29MN NA EU EA WA 1302
    rs5452301,2
    C,F,H60626057(+) AAACAA/CCACCT 1 -- ng51 tfbs38Minor allele frequency- C:0.30EU EA WA 836
    --
    rs342093021,2
    C,F60649181(+) ACTCCC/TGCCTG 1 H/Y mis15Minor allele frequency- T:0.01NA EU EA WA 498
    About this table

    HapMap Linkage Disequilibrium images for CD5 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 153340

    10/27 Novoseek disease relationships for CD5 gene (see all 27 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma small lymphocytic 77.30 5 9043774 (1), 9796727 (1), 1370753 (1), 17430665 (1)
    lymphocytic leukemia chronic b-cell 76.06 8 7513207 (2), 1694698 (1), 8042591 (1), 1694132 (1) (see all 7)
    leukemia lymphocytic chronic 74.76 12 1694698 (1), 9043774 (1), 9796727 (1), 9720730 (1) (see all 10)
    leukaemia lymphocytic 70.22 7 1379132 (1), 7543349 (1), 17325858 (1), 16505276 (1) (see all 7)
    lymphoma lymphocytic 62.10 1 1370753 (1)
    lymphoma b-cell 60.21 9 9796727 (2), 17430665 (1), 8561085 (1), 19279536 (1) (see all 5)
    lymphoma 59.32 11 17430665 (2), 9615189 (2), 9176388 (1), 15629830 (1) (see all 6)
    lymphoma follicular 59.08 1 12375647 (1)
    lymphoma low-grade 57.09 2 12375647 (1), 8561085 (1)
    lymphoproliferative disorders 56.12 4 8457472 (1), 17325858 (1), 18497318 (1)
    About this table

    Genetic Association Database: CD5
    Human Genome Epidemiology Navigator: CD5 (2 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/166 PubMed articles for CD5 gene (see all 166 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 921 HGNC: 1685 AceView: CD5 Ensembl:ENSG00000110448 euGenes: HUgn921
    ECgene: CD5 H-InvDB: CD5
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CD5:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for CD5 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CD5 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for CD5

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