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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD5 Gene

protein-coding   GIFtS: 65
GCID: GC11P060869

CD5 Molecule

(Previous name: CD5 antigen (p56-62))
(Previous symbol: LEU1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD5 Molecule1 2     T12
LEU11 2 3 5     T-Cell Surface Glycoprotein CD52
CD5 Antigen (P56-62)1 2     CD5 Antigen3
Lymphocyte Antigen T1/Leu-12 3     

External Ids:    HGNC: 16851   Entrez Gene: 9212   Ensembl: ENSG000001104487   OMIM: 1533405   UniProtKB: P061273   

Export aliases for CD5 gene to outside databases

Previous GC identifers: GC11P063262 GC11P062382 GC11P061120 GC11P060646 GC11P060647 GC11P060626 GC11P057229


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CD5 Gene: 
CD5 (CD5 molecule) is a protein-coding gene. Diseases associated with CD5 include richter's syndrome, and thymic epithelial tumor. GO annotations related to this gene include scavenger receptor activity and receptor activity.

UniProtKB/Swiss-Prot: CD5_HUMAN, P06127
Function: May act as a receptor in regulating T-cell proliferation

Gene Wiki entry for CD5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD5 gene promoter:
         Max1   USF1   SREBP-1c   FOXD1   POU3F2   SREBP-1b   USF-1   c-Myb   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q13

CD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060869:  view genomic region     (about GC identifiers)

Start:
60,869,867 bp from pter      End:
60,895,324 bp from pter
Size:
25,458 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD5_HUMAN, P06127 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD5 precursor  
Size: 495 amino acids; 54578 Da
Subunit: Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
4 PDB 3D structures from and Proteopedia for CD5:
2JA4 (3D)        2JOP (3D)        2JP0 (3D)        2OTT (3D)    
Secondary accessions: A0N0P4 A8K9I3

Explore the universe of human proteins at neXtProt for CD5: NX_P06127

Explore proteomics data for CD5 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06127

  • CD5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD5 Protein Expression
    REFSEQ proteins: NP_055022.2  
    ENSEMBL proteins: 
     ENSP00000342681   ENSP00000440899  

    Human Recombinant Protein Products for CD5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD5
    OriGene Protein Over-expression Lysate for CD5
    OriGene MassSpec for CD5 
    OriGene Custom Protein Services for CD5
    GenScript Custom Purified and Recombinant Proteins Services for CD5
    Novus Biologicals CD5 Proteins
    Novus Biologicals CD5 Lysate
    Sino Biological Recombinant Protein for CD5
    Sino Biological Cell Lysate for CD5 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CD5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA11390434
    GO:0005887integral to plasma membrane NAS1711157
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----

    CD5 for ontologies           About GeneDecksing



    CD5 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD5
    R&D Systems Antibodies for CD5
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    Abcam antibodies for CD5
    Cloud-Clone Corp. Antibodies for CD5 
    ThermoFisher Antibody for CD5
    LSBio Antibodies in human, mouse, rat for CD5 

    Assay Products for CD5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD5
    R&D Systems Proteome Profiler Antibody Arrays for CD5
    GenScript Custom Assay Services for CD5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD5 
    Cloud-Clone Corp. CLIAs for CD5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    3 InterPro protein domains:
     IPR001190 Srcr_rcpt
     IPR003566 Tcell_CD5
     IPR017448 Srcr_rcpt-rel

    Graphical View of Domain Structure for InterPro Entry P06127

    ProtoNet protein and cluster: P06127

    2 Blocks protein domains:
    IPB001190 Speract/scavenger receptor
    IPB003566 T-cell surface glycoprotein CD5 signature


    UniProtKB/Swiss-Prot: CD5_HUMAN, P06127
    Similarity: Contains 3 SRCR domains


    CD5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD5_HUMAN, P06127
    Function: May act as a receptor in regulating T-cell proliferation

         Genatlas biochemistry entry for CD5:
    cell differentiation antigen CD5 (p56-62),expressed on thymocytes,T and B cells,single chain,identified by
    monoclonal antibodies T1,UCHT2,T101,HH9,AMG4

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity NAS1711157
    GO:0004888transmembrane signaling receptor activity NAS3093892
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding IPI1711157
         
    CD5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD5:
     Decreased Wnt reporter activit 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cd5):
     cellular  hematopoietic system  immune system  no phenotypic analysis  normal 

    CD5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd5tm1Cgn for CD5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD5
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CD5 (see all 13):
    hsa-miR-345 hsa-miR-631 hsa-miR-520d-5p hsa-miR-516b* hsa-miR-3661 hsa-miR-211 hsa-miR-3922-3p hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidCD5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD5
    Sirion Biotech Customized adenovirus for overexpression of CD5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD5 (see all 7)
    OriGene ORF clones in mouse, rat for CD5
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    GenScript: all cDNA clones in your preferred vector: CD5 (NM_014207)
    Sino Biological Human cDNA Clone for CD5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD5
    Sirion Biotech Customized lentivirus for stable overexpression of CD5 
                         Customized lentivirus expression plasmids for stable overexpression of CD5 

    Cell Line
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    Search LifeMap BioReagents cell lines for CD5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway
    2Hematopoietic cell lineage
    Hematopoietic cell lineage

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CD5
        B Cell Receptor Signaling Pathway



    1         Kegg Pathway  (Kegg details for CD5):
        Hematopoietic cell lineage


    CD5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/25 Interacting proteins for CD5 (P061272, 3 ENSP000003426814) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8034694 MINT-8034710 I2D: score=3 STRING: ENSP00000274335
    RASA1P209362, 3, ENSP000002743764MINT-8037472 I2D: score=4 STRING: ENSP00000274376
    CD2P067293, ENSP000003584904I2D: score=3 STRING: ENSP00000358490
    CD6P302033, ENSP000003232804I2D: score=3 STRING: ENSP00000323280
    ZAP70P434033, ENSP000002649724I2D: score=3 STRING: ENSP00000264972
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008037cell recognition NAS1711157
    GO:0008283cell proliferation NAS3093892
    GO:0031295T cell costimulation IEA--
    GO:0097190apoptotic signaling pathway IEA--

    CD5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD5

    5 Novoseek inferred chemical compound relationships for CD5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gelonin 69.6 2 7541032 (1), 8659923 (1)
    ricin 51.7 1 1722193 (1)
    paraffin 18.9 4 9615189 (3), 12890804 (1)
    calcium 0 1 10540344 (1)
    tyrosine 0 8 11298344 (4), 8898942 (1), 17325858 (1), 10540344 (1)

    Search CenterWatch for drugs/clinical trials and news about CD5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD5 gene: 
    NM_014207.3  

    Unigene Cluster for CD5:

    CD5 molecule
    Hs.58685  [show with all ESTs]
    Unigene Representative Sequence: NM_014207
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347785(uc009ynk.3) ENST00000544014
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD5
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CD5 (see all 13):
    hsa-miR-345 hsa-miR-631 hsa-miR-520d-5p hsa-miR-516b* hsa-miR-3661 hsa-miR-211 hsa-miR-3922-3p hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidCD5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD5
    Clone
    Products:
         
    OriGene clones in human, mouse for CD5 (see all 7)
    OriGene ORF clones in mouse, rat for CD5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CD5 (NM_014207)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD5
    Sirion Biotech Customized lentivirus for stable overexpression of CD5 
                         Customized lentivirus expression plasmids for stable overexpression of CD5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD5
    OriGene qSTAR qPCR primer pairs in human, mouse for CD5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD5

    Additional mRNA sequence: 

    AK292698.1 AY541703.1 BC027901.1 X04391.1 

    3 DOTS entries:

    DT.412598  DT.120716096  DT.120716185 

    24/56 AceView cDNA sequences (see all 56):

    F26511 AA309891 AY541703 AI670004 BX107940 BM704160 CD625269 BC027901 
    AI650591 X04391 CD625276 AA025269 NM_014207 BI909143 AW594651 AA235742 
    AA406028 CD625265 CD625268 CD625272 AA406027 CD625273 BQ881887 CD625267 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD5 expression in normal human tissues (normalized intensities)      CD5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACACATC
    CD5 Expression
    About this image


    CD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 8 entries
             T-Cytotoxic Cells Peripheral Blood
             Peripheral blood Pan-T Cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Cord Blood CD133- Cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   

    See CD5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD5

    SOURCE GeneReport for Unigene cluster: Hs.58685
        SABiosciences Expression via Pathway-Focused PCR Arrays including CD5: 
              Cell Surface Markers in human mouse rat
              Lymphoma in human mouse rat
              Apoptosis 384HT in human mouse rat
              Antifungal Response in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD5 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd51 , 5 CD5 antigen1, 5 73.53(n)1
    64.61(a)1
      19 (7.16 cM)5
    125071  NM_007650.31  NP_031676.31 
     107181435 
    chicken
    (Gallus gallus)
    Aves CD51 CD5 molecule 52.06(n)
    41.51(a)
      395757  NM_204921.1  NP_990252.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD56
    CD5 molecule
    32(a)
    1 ↔ 1
    GL343235.1(641054-666069)


    ENSEMBL Gene Tree for CD5 (if available)
    TreeFam Gene Tree for CD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/690 SNPs in CD5 are shown (see all 690)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888651121,2
    --60868011(+) CACACA/CCATAA 1 -- us2k10--------
    rs1926005081,2
    --60868015(+) CACATA/CAACAT 1 -- us2k10--------
    rs1845838701,2
    --60868052(+) GAGATC/TACACA 1 -- us2k10--------
    rs2005760571,2
    C--60868149(+) ACATTC/TACACA 1 -- us2k10--------
    rs2001509221,2
    C--60868606(+) CATCA-/CATGGA 1 -- us2k10--------
    rs1881988331,2
    --60868650(+) TCATCA/CACATG 1 -- us2k10--------
    rs1820310831,2
    C--60868843(+) CACACA/GCACAT 1 -- us2k10--------
    rs1806827241,2
    --60868861(+) GAGATC/TACACA 1 -- us2k10--------
    rs2017884171,2
    C--60868871(+) ACACA-/CGTCAAC 1 -- us2k10--------
    rs3690287441,2
    C--60868923(+) TTCAC-/CACACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD5 (60869867 - 60895324 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509412CNV Insertion20534489
    nsv526162CNV Loss19592680
    nsv897602CNV Loss21882294
    nsv428259CNV Gain+Loss18775914
    nsv832176CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): CD5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD5
    DNA2.0 Custom Variant and Variant Library Synthesis for CD5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153340    OMIM disorders: --

    20/52 diseases for CD5 (see all 52):    About MalaCards
    richter's syndrome    thymic epithelial tumor    type ii mixed cryoglobulinemia    thymic carcinoma
    diffuse large b-cell lymphoma    mixed cryoglobulinemia    intravascular large b-cell lymphoma    malt lymphoma
    prolymphocytic leukemia    t-cell prolymphocytic leukemia    b cell prolymphocytic leukemia    mantle cell lymphoma
    systemic mastocytosis    splenic marginal zone lymphoma    lymphatic system disease    cryoglobulinemia
    b-cell chronic lymphocytic leukemia    thymoma    mastocytosis    marginal zone b-cell lymphoma

    9 diseases from the University of Copenhagen DISEASES database for CD5:
    Lymphoma     Leukemia     Thymic carcinoma     Hypersensitivity reaction type II disease
    Macroglobulinemia     Thymoma     Anemia     Rheumatoid arthritis
    Cryoglobulinemia

    CD5 for disorders           About GeneDecksing

    10/28 Novoseek inferred disease relationships for CD5 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma small lymphocytic 76.3 6 9043774 (1), 9796727 (1), 1370753 (1), 17430665 (1)
    lymphocytic leukemia chronic b-cell 75.3 8 7513207 (2), 1694698 (1), 8042591 (1), 1694132 (1) (see all 7)
    leukemia lymphocytic chronic 74.3 13 1694698 (1), 9043774 (1), 9796727 (1), 9720730 (1) (see all 10)
    leukemia prolymphocytic 70.3 1 20134145 (1)
    leukaemia lymphocytic 69.2 7 1379132 (1), 7543349 (1), 17325858 (1), 16505276 (1) (see all 7)
    lymphoma lymphocytic 61 1 1370753 (1)
    lymphoproliferative disorders 60.7 4 8457472 (1), 17325858 (1), 18497318 (1)
    lymphoma 58.8 11 17430665 (2), 9615189 (2), 9176388 (1), 15629830 (1) (see all 6)
    lymphoma b-cell 58.5 8 9796727 (2), 8561085 (1), 19279536 (1), 8724541 (1)
    lymphoma follicular 57.5 1 12375647 (1)

    Genetic Association Database (GAD): CD5
    Human Genome Epidemiology (HuGE) Navigator: CD5 (9 documents)

    Export disorders for CD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD5 gene, integrated from 9 sources (see all 203):
    (articles sorted by number of sources associating them with CD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PubMed id 1711157)1, 2, 3 van de Velde H.... Thielemans K. (1991)
    2. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    3. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    4. Common genetic variants in candidate genes and risk o f familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (2009)
    5. Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5. (PubMed id 18339402)1, 2 Garza-Garcia A....Driscoll P.C. (2008)
    6. Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis. (PubMed id 18006695)1, 4 Sellick G.S....Houlston R.S. (2008)
    7. Polymorphism in the CD5 gene promoter in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. (PubMed id 15981803)1, 4 Perez-Chacon G....Perez-Aciego P. (2005)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)1, 2 Salomon A.R.... Peters E.C. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 921 HGNC: 1685 AceView: CD5 Ensembl:ENSG00000110448 euGenes: HUgn921
    ECgene: CD5 Kegg: 921 H-InvDB: CD5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD5 gene:
    Search GeneIP for patents involving CD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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