 |
 | Services
| |
 |
Aliases & Descriptions for CD5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| LEU1 2, 3, 5 | | T1 1, 2 |
| | | Descriptions |
|---|
| CD5 antigen 3 | | CD5 antigen (p56-62) 1, 2 | | CD5 molecule 2 | | Lymphocyte antigen T1/Leu-1 3 |
|
| | Search outside databases for aliases for CD5 genePrevious GC identifers: GC11P063262 GC11P062382 GC11P061120 GC11P060646 GC11P060647 |
Summaries for CD5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: CD5_HUMAN, P06127Function: May act as a receptor in regulating T-cell proliferation. CD5 interacts with CD72/LYB-2Gene Wiki entry for CD5 |
Genomic Location for CD5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CD5 gene 
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q13CD5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P060626:
(about GC identifiers)
Start:
|
60,626,543 bp from pter |
End:
|
60,651,900 bp from pter |
Size:
|
25,358 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033903.7
| Proteins for CD5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CD5_HUMAN, P06127 (See
protein sequence)Recommended Name: T-cell surface glycoprotein CD5 precursor Size: 495 amino acids; 54625 Da
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :2JA4 (3D)
 2JOP (3D)
 2JP0 (3D)
 2OTT (3D)
 
Secondary accessions: A0N0P4Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055022.2
ENSEMBL proteins: ENSP00000342681
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for CD5: Assays for CD5: | Protein
Domains/ Families for CD5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P06127
ProtoNet protein and cluster: P06127 2 Blocks protein families: IPB001190 Speract/scavenger receptor IPB003566 T-cell surface glycoprotein CD5 signature
UniProtKB/Swiss-Prot: CD5_HUMAN, P06127Similarity: Contains 3 SRCR domains | Gene Function for CD5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014207
Applied Biosystems Silencer® siRNAs for CD5
Sigma-Aldrich siRNA and siRNA Panels for CD5  Sigma-Aldrich shRNA Panels and shRNA for CD5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014207                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014207                                  untagged cDNA clone in CMV expression vector: NM_014207 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014207
UniProtKB/Swiss-Prot: CD5_HUMAN, P06127Function: May act as a receptor in regulating T-cell proliferation. CD5 interacts with CD72/LYB-2Genatlas biochemistry entry for CD5:cell differentiation antigen CD5 (p56-62),expressed on thymocytes,T and B cells,single chain,identified by monoclonal antibodies T1,UCHT2,T101,HH9,AMG43 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cd5):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for CD5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for CD5 
5/82 Interacting proteins for CD5 (ENSP000003426813) via UniProtKB, MINT, and/or STRING (see all 82
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for CD5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CD5 3 Novoseek chemical compound relationships for CD5 gene
About this table
|
Transcripts for CD5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014207
Sigma-Aldrich siRNA and siRNA Panels for CD5  Sigma-Aldrich shRNA Panels and shRNA for CD5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014207 REFSEQ mRNAs for CD5 gene: NM_014207.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014207               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014207                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014207                                  untagged cDNA clone in CMV expression vector: NM_014207  Additional cDNA sequence: AK292698.1 AY541703.1 BC027901.1 X04391.1 3 DOTS entries: DT.412598 DT.120716096 DT.120716185 24/56 AceView cDNA sequences (see all 56
):F26511 AY541703 AA309891 BM704160 BX107940 AI670004 CD625271 AW594651 AA235742 AA311437 CD625265 CD625275 CD625267 AL557643 X04391 AA406028 CD625261 BM550047 AA406027 BQ881887 AA309449 BC027901 CD625264 AI650591
highest scoring ESTs for CD5:AI797836 X04391 AA024392 AA025269 AA235742 AA309891 AA310062 AA311437 AA354313 AA406027 Unigene Cluster for CD5: CD5 molecule Hs.58685 [show with all ESTs]Unigene Representative Sequence: NM_014207
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000347785
|
Expression for CD5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CD5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CD5
1 / 2 / 3 6 probe-sets matching CD5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGAACACATC
SOURCE GeneReport for Unigene cluster: Hs.58685
Expression variation in blood from EXPOLDB for CD5 |
Orthologs for CD5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CD5 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for CD5
ENSEMBL Gene Tree for CD5 | Paralogs for CD5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for CD5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CD5 (up to first 250kb)
|
Disorders & Mutations for CD5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 153340
10/27 Novoseek disease relationships for CD5 gene (see all 27
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lymphoma small lymphocytic |
77.30 |
5 |
9043774 (1), 9796727 (1), 1370753 (1), 17430665 (1) |
| lymphocytic leukemia chronic b-cell |
76.06 |
8 |
7513207 (2), 1694698 (1), 8042591 (1), 1694132 (1) (see all 7) |
| leukemia lymphocytic chronic |
74.76 |
12 |
1694698 (1), 9043774 (1), 9796727 (1), 9720730 (1) (see all 10) |
| leukaemia lymphocytic |
70.22 |
7 |
1379132 (1), 7543349 (1), 17325858 (1), 16505276 (1) (see all 7) |
| lymphoma lymphocytic |
62.10 |
1 |
1370753 (1) |
| lymphoma b-cell |
60.21 |
9 |
9796727 (2), 17430665 (1), 8561085 (1), 19279536 (1) (see all 5) |
| lymphoma |
59.32 |
11 |
17430665 (2), 9615189 (2), 9176388 (1), 15629830 (1) (see all 6) |
| lymphoma follicular |
59.08 |
1 |
12375647 (1) |
| lymphoma low-grade |
57.09 |
2 |
12375647 (1), 8561085 (1) |
| lymphoproliferative disorders |
56.12 |
4 |
8457472 (1), 17325858 (1), 18497318 (1) |
About this table
Genetic Association Database: CD5 Human Genome Epidemiology Navigator: CD5 (2 documents)
|
Medical News for CD5(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for CD5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/166 PubMed articles for CD5 gene (see all 166
):- The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PubMed id 1711157)2, 3, 4 Van de Velde H....Thielemans K. (1991)
- Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5. (PubMed id 18339402)3, 4 Garza-Garcia A....Driscoll P.C. (2008)
- Polymorphism in the CD5 gene promoter in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. (PubMed id 15981803)3, 6 Perez-Chacon G....Perez-Aciego P. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)3, 4 Salomon A.R.... Peters E.C. (2003)
- Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1. (PubMed id 3093892)3, 4 Jones N.H....Strominger J.L. (1986)
- An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes. (PubMed id 15998834)1, 3 Renaudineau Y.... Youinou P. (2005)
- CD5 does not regulate the signaling triggered through BCR in B cells from a subset of B-CLL patients. (PubMed id 17325858)1, 3 Perez-Chacon G....Perez-Aciego P. (2007)
- Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases. (PubMed id 11298344)1, 3 Vila J.M....Lozano F. (2001)
- Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes. (PubMed id 1385158)1, 3 Osman N....Crumpton M.J. (1992)
|
Search for CD5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CD5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CD5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for CD5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CD5:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for CD5 |
|
 |
 | | | Antibodies for CD5 |
| |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|