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Aliases & Descriptions for CD48
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BCM1 2, 3, 5 | | BLAST 1, 2 | | BLAST1 2, 3, 5 | | MEM-102 2 | | OTTHUMP00000025680 2 | | OTTHUMP00000060268 2 | | SLAMF2 1, 2 | | TCT.1 3 | | hCD48 1, 2 | | mCD48 1, 2 |
| | | Descriptions |
|---|
| B-lymphocyte activation marker BLAST-1 3 | | BCM1 surface antigen 3 | | CD48 antigen 3 | | CD48 antigen (B-cell membrane protein) 1, 2 | | CD48 molecule 1, 2 | | Leukocyte antigen MEM-102 3 |
|
| | Search outside databases for aliases for CD48 genePrevious GC identifers: GC01M158440 GC01M156380 GC01M157426 GC01M157865 GC01M157461 |
Summaries for CD48(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CD48: BLAST1 is the designation used for an activation-associated cell surface glycoprotein of 40 to 45 kD expressed primarily in mitogen-stimulated human lymphocytes. The protein sequence predicted by the cDNA encoding BLAST1 indicates that BLAST1 is a member of the immunoglobulin supergene family. Yokoyama (1991) identified the BLAST1 activation/adhesion molecule as CD48.[supplied by OMIM] UniProtKB/Swiss-Prot: CD48_HUMAN, P09326Function: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activationGene Wiki entry for CD48 |
Genomic Location for CD48
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CD48 gene 
Entrez Gene cytogenetic band: 1q21.3-q22 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q21.3-q22CD48 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M158915:
(about GC identifiers)
Start:
|
158,915,160 bp from pter |
End:
|
158,948,217 bp from pter |
Size:
|
33,058 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for CD48
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CD48_HUMAN, P09326 (See
protein sequence)Recommended Name: CD48 antigen precursor Size: 243 amino acids; 27683 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
PDB structures from and Proteopedia :2EDO (3D)
 REFSEQ proteins: NP_001769.2
ENSEMBL proteins: ENSP00000357025 ENSP00000357024
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for CD48: Assays for CD48: | Protein
Domains/ Families for CD48(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P09326
ProtoNet protein and cluster: P09326 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: CD48_HUMAN, P09326Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain | Gene Function for CD48
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001778
Applied Biosystems Silencer® siRNAs for CD48
Sigma-Aldrich siRNA and siRNA Panels for CD48  Sigma-Aldrich shRNA Panels and shRNA for CD48  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001778                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001778                                  untagged cDNA clones in CMV expression vector (see all 2): BC030224 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001778
UniProtKB/Swiss-Prot: CD48_HUMAN, P09326Function: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activationGenatlas biochemistry entry for CD48:cell differentiation antigen CD48,?41kDa,identified by monoclonal antibodies WM68,LO-MN25,J4-57,Tu145,WM63,K31,Ig superfamily2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cd48):
1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for CD48
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for CD48 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for CD48 
5/35 Interacting proteins for CD48 (P093262 ENSP000003570253) via UniProtKB, MINT, and/or STRING (see all 35
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for CD48(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CD48 2 Novoseek chemical compound relationships for CD48 gene
About this table
|
Transcripts for CD48(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001778
Sigma-Aldrich siRNA and siRNA Panels for CD48  Sigma-Aldrich shRNA Panels and shRNA for CD48  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001778 REFSEQ mRNAs for CD48 gene: NM_001778.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001778               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001778                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001778                                  untagged cDNA clones in CMV expression vector (see all 2): BC030224  Additional cDNA sequence: AK225636.1 AK310624.1 AK310744.1 BC016182.1 BC030224.1 BT019813.1 CR457012.1 M37766.1 M59904.1 X06341.1 6 DOTS entries: DT.113022 DT.91730973 DT.102570 DT.100746857 DT.121408933 DT.91760771 24/120 AceView cDNA sequences (see all 120
):AI809979 BM904243 AI810737 AA994239 BI906378 BM458629 AA353776 BF797632 AA825750 BQ049980 BM806842 AA361395 BG393102 N76729 BM922685 BM698549 BC030224 AI378026 BG503524 AI670037 AI372042 AA814438 BG754824 NM_001778
highest scoring ESTs for CD48:M37766 AA353776 AA361395 AA488894 AI809979 AJ705892 AW945143 AW955417 BC016182 BC030224 Unigene Cluster for CD48: CD48 molecule Hs.243564 [show with all ESTs]Unigene Representative Sequence: BC030224
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000368046
ENST00000368045
|
Expression for CD48
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CD48 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CD48
1 / 2 / 3 6 probe-sets matching CD48 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.243564
Expression variation in blood from EXPOLDB for CD48 |
Orthologs for CD48
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CD48 gene from 5 species
About this table Species with no ortholog for CD48
ENSEMBL Gene Tree for CD48 | Paralogs for CD48(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for CD48(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CD48 (up to first 250kb)
|
Disorders & Mutations for CD48
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 109530
1 Novoseek disease relationship for CD48 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0.00 |
1 |
15998796 (1) |
About this table
1 PharmGKB disease relationship for CD48 geneAbout this table
Human Genome Epidemiology Navigator: CD48 (2 documents)
|
Medical News for CD48(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for CD48 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/63 PubMed articles for CD48 gene (see all 63
):- Molecular cloning of the lymphocyte activation marker Blast-1. (PubMed id 2828034)2, 3, 4 Staunton D.E. and Thorley-Lawson D.A. (1987)
- The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1. (PubMed id 1999350)1, 3, 4 Korinek V.... Horejsi V. (1991)
- Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48). (PubMed id 1847502)1, 3, 4 Fisher R.C. and Thorley-Lawson D.A. (1991)
- TCT.1, a target molecule for gamma/delta T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1. (PubMed id 1827826)1, 3, 4 del Porto P.... Hercend T. (1991)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The isolation of cDNA clones for CD48. (PubMed id 1999351)3, 4 Vaughan H.A....Sandrin M.S. (1991)
- CD48 is an allergen and IL-3-induced activation molecule on eosinophils. (PubMed id 16785501)1, 3 Munitz A....Levi-Schaffer F. (2006)
- Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48. (PubMed id 16803907)1, 3 Evans E.J....Davis S.J. (2006)
- Identification of the 2B4 molecule as a counter-receptor for CD48. (PubMed id 9834056)1, 3 Latchman Y....Reiser H. (1998)
|
Search for CD48
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CD48
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CD48
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD48(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for CD48(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CD48:

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