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CD48 Gene

protein-coding   GIFtS: 61
GCID: GC01M160648

CD48 Molecule

(Previous names: CD48 antigen (B-cell membrane protein), CD48 molecule )
(Previous symbol: BCM1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD48 Molecule1 2     B-Lymphocyte Activation Marker BLAST-12 3
BCM11 2 3 5     BCM1 Surface Antigen2 3
BLAST12 3 5     CD48 Antigen2 3
CD48 Antigen (B-Cell Membrane Protein)1 2     SLAM Family Member 22 3
Leukocyte Antigen MEM-1022 3     BLAST2
Signaling Lymphocytic Activation Molecule 22 3     MEM-1022
SLAMF22 3     hCD482
TCT.12 3     mCD482

External Ids:    HGNC: 16831   Entrez Gene: 9622   Ensembl: ENSG000001170917   OMIM: 1095305   UniProtKB: P093263   

Export aliases for CD48 gene to outside databases

Previous GC identifers: GC01M158440 GC01M156380 GC01M157426 GC01M157865 GC01M157461 GC01M158915 GC01M132004


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD48 Gene:
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling
lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other
immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways
in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell
surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec
2011)

GeneCards Summary for CD48 Gene:
CD48 (CD48 molecule) is a protein-coding gene. GO annotations related to this gene include antigen binding and receptor activity.

UniProtKB/Swiss-Prot: CD48_HUMAN, P09326
Function: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in
regulating T-cell activation

Gene Wiki entry for CD48 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD48 gene promoter:
         c-Fos   AP-1   JunB   p300   Fra-1   FosB   C/EBPalpha   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD48 promoter sequence
   Search Chromatin IP Primers for CD48

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD48


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3-q22   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q21.3-q22

CD48 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD48 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160648:  view genomic region     (about GC identifiers)

Start:
160,648,536 bp from pter      End:
160,681,641 bp from pter
Size:
33,106 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CD48_HUMAN, P09326 (See protein sequence)
Recommended Name: CD48 antigen precursor  
Size: 243 amino acids; 27683 Da
Subunit: Interacts with CD244 in an heterophilic manner (By similarity)
1 PDB 3D structure from and Proteopedia for CD48:
2EDO (3D)    
Secondary accessions: Q5U055

Explore the universe of human proteins at neXtProt for CD48: NX_P09326

Explore proteomics data for CD48 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn40, Asn44, Asn104, Asn162, Asn178, Asn189, Asn206
  • Modification sites at PhosphoSitePlus

  • See CD48 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001242959.1  NP_001769.2  

    ENSEMBL proteins: 
     ENSP00000357025   ENSP00000357024  
    Reactome Protein details: P09326

    CD48 Human Recombinant Protein Products:

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    Novus Biologicals CD48 Proteins
    Novus Biologicals CD48 Lysates
    Sino Biological Recombinant Protein for CD48
    Sino Biological Cell Lysate for CD48
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD48 

     
    antibodies-online proteins for CD48 (16 products) 

     
    antibodies-online peptides for CD48

    CD48 Antibody Products:

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    Abcam antibodies for CD48
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    antibodies-online antibodies for CD48 (195 products) 

    CD48 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for CD48 
    antibodies-online kits for CD48 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR015631 SLAM_fam_rcpts
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P09326

    ProtoNet protein and cluster: P09326

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: CD48_HUMAN, P09326
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CD48           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD48_HUMAN, P09326
    Function: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in
    regulating T-cell activation

         Genatlas biochemistry entry for CD48:
    cell differentiation antigen CD48,?41kDa,identified by monoclonal antibodies WM68,LO-MN25,J4-57,Tu145,WM63,K31,Ig
    superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding IEA--
    GO:0004872receptor activity IEA--
    GO:0005515protein binding IPI12356317
         
    Find genes that share ontologies with CD48           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CD48:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd48):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CD48           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cd48tm1Rsr for CD48

       genOway: Develop your customized and physiologically relevant rodent model for CD48

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCD48 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD48


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD48_HUMAN, P09326: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    chloroplast1
    lysosome1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1693656
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane ----
    GO:0043234protein complex IEA--

    Find genes that share ontologies with CD48           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD48 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Immune response Role of DAP12 receptors in NK cells
    Natural killer cell mediated cytotoxicity0.31
    3Gastric cancer network 2
    Gastric cancer network 2
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall


    Find genes that share SuperPaths with CD48           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CD48
        Gastric cancer network 2


    1 Reactome Pathway for CD48
        Cell surface interactions at the vascular wall


    1 Kegg Pathway  (Kegg details for CD48):
        Natural killer cell mediated cytotoxicity

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD48
    Interactions:

        GeneGlobe Interaction Network for CD48

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for CD48 (P093261, 2, 3 ENSP000003570254) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD244Q9BZW81, 3, ENSP000003570134EBI-714770,EBI-1580565 I2D: score=2 STRING: ENSP00000357013
    ENSG00000206379O759553I2D: score=1 
    ENSG00000206480O759553I2D: score=1 
    ENSG00000230143O759553I2D: score=1 
    ENSG00000232280O759553I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS2828034
    GO:0007165signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0042110T cell activation IEA--
    GO:0045576mast cell activation IEA--

    Find genes that share ontologies with CD48           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD48

    2 Novoseek inferred chemical compound relationships for CD48 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 31.4 3 8898942 (1), 8650218 (1), 9500981 (1)
    lipid 0 2 17446208 (1), 1827826 (1)



    Find genes that share compounds with CD48           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD48 gene (2 alternative transcripts): 
    NM_001256030.1  NM_001778.3  

    Unigene Cluster for CD48:

    CD48 molecule
    Hs.243564  [show with all ESTs]
    Unigene Representative Sequence: BC030224
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368046(uc001fwn.3 uc001fwo.1) ENST00000368045(uc001fwp.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD48 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CD48:
    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCD48 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD48
      QuantiTect SYBR Green Assays in human, mouse, rat CD48
      QuantiFast Probe-based Assays in human, mouse, rat CD48

    Additional mRNA sequence: 

    AK225636.1 AK310624.1 AK310744.1 BC016182.1 BC030224.1 BT019813.1 CR457012.1 M37766.1 
    M59904.1 X06341.1 

    6 DOTS entries:

    DT.113022  DT.91730973  DT.102570  DT.100746857  DT.121408933  DT.91760771 

    Selected AceView cDNA sequences (see all 120):

    BM904243 BF797632 BM458629 AA994239 BM806842 AI809979 BQ049980 AA825750 
    BM698549 AI378026 BM922685 BI906378 N76729 BC030224 AA361395 AA353776 
    BG393102 AI810737 BP338339 BG505217 CD640375 AI719221 BG754824 BE562253 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD48 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD48 Expression
    About this image


    CD48 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Tonsil (Hematopoietic System)
    CD48 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD48 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.243564
        Custom PCR Arrays for CD48
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD48

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD48 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd481 , 5 CD48 antigen1, 5 65.6(n)1
    52.75(a)1
      1 (79.54 cM)5
    125061  NM_007649.41  NP_031675.11 
     1716820095 


    ENSEMBL Gene Tree for CD48 (if available)
    TreeFam Gene Tree for CD48 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD48 (see all 999)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828766781,2
    --160648041(+) CCTGGA/GGGCGC 1 -- ds50010--------
    rs1390067431,2
    --160648080(+) GAGAAC/TACTGT 1 -- ds50010--------
    rs1879157741,2
    --160648083(+) AACACG/TGTGTC 1 -- ds50010--------
    rs1422108871,2
    --160648119(+) TGAAAC/TGACTA 1 -- ds50010--------
    rs1448516471,2
    --160648157(+) ATGGAA/GAAGAG 1 -- ds50010--------
    rs1908274991,2
    --160648162(+) AAAGAA/GGAGAG 1 -- ds50010--------
    rs1485476811,2
    C--160648192(+) GAGGCC/TTGTGG 1 -- ds50010--------
    rs1822861261,2
    --160648215(+) TCTTAC/TGAGAT 1 -- ds50010--------
    rs1129516101,2
    C--160648230(+) CTGCAT/ACCTTC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs15534561,2
    C,F,O,H--160648396(+) TCAGAA/GGTAGC 1 -- ds500136Minor allele frequency- N:0.00NS EA NA WA CSA 3074

    HapMap Linkage Disequilibrium report for CD48 (160648536 - 160681641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD48:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv506962CNV Insertion20534489
    nsv437213CNV Loss16327808
    nsv508042CNV Loss20534489
    nsv831714CNV Gain17160897
    nsv511001CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD48
    DNA2.0 Custom Variant and Variant Library Synthesis for CD48

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109530    OMIM disorders: --


    Find genes that share disorders with CD48           About GenesLikeMe

    1 Novoseek inferred disease relationship for CD48 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 15998796 (1)

    Genetic Association Database (GAD): CD48
    Human Genome Epidemiology (HuGE) Navigator: CD48 (7 documents)

    Export disorders for CD48 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD48 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with CD48)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the lymphocyte activation marker Blast-1. (PubMed id 2828034)1, 2, 3 Staunton D.E. and Thorley-Lawson D.A. (EMBO J. 1987)
    2. The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1. (PubMed id 1999350)1, 2, 9 Korinek V.... Horejsi V. (Immunogenetics 1991)
    3. Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48). (PubMed id 1847502)1, 2, 9 Fisher R.C. and Thorley-Lawson D.A. (Mol. Cell. Biol. 1991)
    4. TCT.1, a target molecule for gamma/delta T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1. (PubMed id 1827826)1, 2, 9 del Porto P.... Hercend T. (J. Exp. Med. 1991)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Polymorphisms in human endogenous retrovirus K-18 and risk of type 2 diabetes in individuals with schizophrenia. (PubMed id 18617371)1, 4 Dickerson F....Yolken R. (Schizophr. Res. 2008)
    8. Neither an intronic CA repeat within the CD48 gene nor the HERV-K18 polymorphisms are associated with type 1 diabetes. (PubMed id 16866884)1, 4 Ramos-Lopez E....Badenhoop K. (Tissue Antigens 2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 962 HGNC: 1683 AceView: CD48 Ensembl:ENSG00000117091 euGenes: HUgn962
    ECgene: CD48 Kegg: 962 H-InvDB: CD48

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD48 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD48 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for CD48 gene:
    Search GeneIP for patents involving CD48

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