CD48 Gene

Aliases
for CD48 gene

Previous GC identifers: GC01M158440 GC01M156380 GC01M157426 GC01M157865 GC01M157461 GC01M158915 GC01M132004

Summaries
for CD48 gene

Genomic Views
for CD48 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_004487.19  

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD48 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD48

CD48 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160648:  view genomic region     (about GC identifiers)

Proteins
for CD48 gene

1 PDB 3D structure from and Proteopedia for CD48:

2EDO (3D)    

Explore the universe of human proteins at neXtProt for CD48: NX_P09326

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD48 (CD48/SLAMF2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CD48 OriGene Custom Protein Services for CD48
	GenScript Custom Purified and Recombinant Proteins Services for CD48
	Novus Biologicals CD48 Proteins Novus Biologicals CD48 Lysates
	Sino Biological Recombinant Protein for CD48
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD48

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD48 (CD48/SLAMF2)
	OriGene Antibodies: CD48 OriGene Custom Antibody Services for CD48
	GenScript Custom Superior Antibodies Services for CD48
	Novus Biologicals CD48 Antibodies
	Abcam antibodies for CD48
	Uscn Antibodies for CD48
	ThermoFisher Antibody for CD48

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CD48 (CD48/SLAMF2)
	GenScript Custom Assay Services for CD48
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD48

Protein Domains /
Families
for CD48 gene

ProtoNet protein and cluster: P09326

Function
for CD48 gene

miRNA Products:		OriGene 3'-UTR Clone: CD48 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD48
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CD48:
		hsa-miR-3163
		SwitchGear 3'UTR luciferase reporter plasmid: CD48 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD48 (see all 7) OriGene shRNA RFP: CD48 OriGene siRNA: CD48
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD48

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD48

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD48 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD48 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CD48 (NM_001778)
		Sino Biological Human cDNA Clone for CD48
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD48
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD48

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD48
		Search LifeMap BioReagents cell lines for CD48

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD48

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Cd48)

Pathways & Interactions
for CD48 gene

	Super-pathway	contained gene-specific pathways
1	Natural killer cell mediated cytotoxicity	Natural killer cell mediated cytotoxicity 1.00
2	Cell surface interactions at the vascular wall	Cell surface interactions at the vascular wall 1.00
3	Platelet activation, signaling and aggregation	Hemostasis 0.43

2        Reactome Pathways for CD48

	Hemostasis
	Cell surface interactions at the vascular wall

1         Kegg Pathway  (Kegg details for CD48)

Natural killer cell mediated cytotoxicity

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for CD48 gene

Transcripts
for CD48 gene

Expression
for CD48 gene

CD48 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneBone MarrowHematopoietic Stem Cells			Blood
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	Mesendoderm-like cells (Generation of mesend...)
	Definitive endoderm-like cells (A scalable, suspensi...)
	Definitive Endoderm (Generation of beta c...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD48 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD48
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD48
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD48

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD48

Orthologs
for CD48 gene

Paralogs
for CD48 gene

Genomic Variants
for CD48 gene

10/842 NCBI SNPs in CD48 are shown (see all 842)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1828766781,2		--	160648041(+)	CCTGGA/GGGCGC	1	--	ds5001		0	--	--	--	--
rs1390067431,2		--	160648080(+)	GAGAAC/TACTGT	1	--	ds5001		0	--	--	--	--
rs1879157741,2		--	160648083(+)	AACACG/TGTGTC	1	--	ds5001		0	--	--	--	--
rs1422108871,2		--	160648119(+)	TGAAAC/TGACTA	1	--	ds5001		0	--	--	--	--
rs1448516471,2		--	160648157(+)	ATGGAA/GAAGAG	1	--	ds5001		0	--	--	--	--
rs1908274991,2		--	160648162(+)	AAAGAA/GGAGAG	1	--	ds5001		0	--	--	--	--
rs1485476811,2		--	160648192(+)	GAGGCC/TTGTGG	1	--	ds5001		0	--	--	--	--
rs1822861261,2		--	160648215(+)	TCTTAC/TGAGAT	1	--	ds5001		0	--	--	--	--
rs15534561,2	C,F,O,H,	--	160648396(+)	TCAGAA/GGTAGC	1	--	ds5001		36		NS EA NA WA CSA	3074
rs120965891,2	C,F,H,	--	160648481(+)	CCAGTT/GTCTCC	1	--	ds5001		17		NS EA NA WA	2340

HapMap Linkage Disequilibrium report for CD48 (160648536 - 160681641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD48
     1 CNV: 1338

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD48

DNA2.0 Custom Variant and Variant Library Synthesis for CD48

Disorders / Diseases
for CD48 gene

11 diseases for CD48

1 Novoseek disease relationship for CD48 gene    About this table

Publications
for CD48 gene

PubMed articles for CD48 gene, integrated from 9 sources (see all 75): (articles sorted by number of sources associating them with CD48)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning of the lymphocyte activation marker Blast-1. (PubMed id 2828034)^{1, 2, 3} Staunton D.E. and Thorley-Lawson D.A. (1987)
2. The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1. (PubMed id 1999350)^{1, 2, 9} Korinek V.... Horejsi V. (1991)
3. Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48). (PubMed id 1847502)^{1, 2, 9} Fisher R.C. and Thorley-Lawson D.A. (1991)
4. TCT.1, a target molecule for gamma/delta T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1. (PubMed id 1827826)^{1, 2, 9} del Porto P.... Hercend T. (1991)
5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. The isolation of cDNA clones for CD48. (PubMed id 1999351)^{1, 2} Vaughan H.A....Sandrin M.S. (1991)
8. CD48 is an allergen and IL-3-induced activation molecule on eosinophils. (PubMed id 16785501)^{1, 9} Munitz A....Levi-Schaffer F. (2006)
9. Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48. (PubMed id 16803907)^{1, 9} Evans E.J....Davis S.J. (2006)
10. Identification of the 2B4 molecule as a counter-receptor for CD48. (PubMed id 9834056)^{1, 9} Latchman Y....Reiser H. (1998)

External Searches for CD48 gene

Genome Databases showing CD48 gene

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Specialized Databases showing CD48 gene

Products
for CD48 gene