Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD47 Gene

protein-coding   GIFtS: 62
GCID: GC03M107761

CD47 molecule

(Previous names: CD47 antigen (Rh-related antigen, integrin-associated signal...)
(Previous symbol: MER6)
 Explore 37 diseases affiliated with
CD47 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD47    

Aliases
for CD47 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD47 Molecule1 2     CD47 Glycoprotein2
IAP1 2 3 5     Integrin Associated Protein2
MER61 2 3 5     Integrin-Associated Signal Transducer2
OA31 2     Leukocyte Surface Antigen CD472
CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer)1 2     Rh-Related Antigen2
Antigenic Surface Determinant Protein OA32 3     CD47 Antigen3
Integrin-Associated Protein2 3     Protein MER63
Antigen Identified By Monoclonal Antibody 1D82     

External Ids:    HGNC: 16821   Entrez Gene: 9612   Ensembl: ENSG000001967767   OMIM: 6010285   UniProtKB: Q087223   

Export aliases for CD47 gene to outside databases

Previous GC identifers: GC03M104559 GC03M107293 GC03M109043 GC03M109086 GC03M109083 GC03M109244 GC03M105135


Summaries
for CD47 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD47:
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that
occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell
binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has
broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants
have been found for this gene. (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the
modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By
similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits
cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances
superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane
transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be
involved in membrane permeability changes induced following virus infection

Gene Wiki entry for CD47


Genomic Views
for CD47 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD47 gene promoter:
         ER-alpha   AML1a   FOXL1   HEN1   c-Myb   NF-kappaB1   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD47 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD47

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD47


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.1-q13.2   Ensembl cytogenetic band:  3q13.12   HGNC cytogenetic band: 3q13.1-q13.2

CD47 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD47 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M107761:  view genomic region     (about GC identifiers)

Start:
 107,761,941 bp from pter      End:
 107,809,935 bp from pter
Size:
 47,995 bases      Orientation:
 minus strand

Proteins
for CD47 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722 (See protein sequence)
Recommended Name: Leukocyte surface antigen CD47 precursor  
Size: 323 amino acids; 35214 Da
Subunit: Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2
Subcellular location: Cell membrane; Multi-pass membrane protein
3 PDB 3D structures from and Proteopedia for CD47:
2JJS (3D)        2JJT (3D)        2VSC (3D)    
Secondary accessions: A8K198 D3DN59 Q53Y71 Q96A60
Alternative splicing: 4 isoforms:  Q08722-1   Q08722-2   Q08722-3   Q08722-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CD47: NX_Q08722

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q08722

    • CD47 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001768.1  NP_942088.1  

    ENSEMBL proteins: 
     ENSP00000347512   ENSP00000381309   ENSP00000430843   ENSP00000355361  
    Reactome Protein details: Q08722
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD47
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): CD47
    OriGene Custom Protein Services for CD47 
    GenScript Custom Purified and Recombinant Proteins Services for CD47
    Novus Biologicals CD47 Proteins
    Novus Biologicals CD47 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CD47

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IEA--


    CD47 for ontologies           About GeneDecksing



    CD47 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD47
    OriGene Antibodies: CD47
    OriGene Custom Antibody Services for CD47 
    GenScript Custom Superior Antibodies Services for CD47
    Novus Biologicals CD47 Antibodies
    Abcam antibodies for CD47 
    Uscn Antibodies for CD47
    ThermoFisher Antibody for CD47

    Assay Products for CD47: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD47
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CD47

    Protein Domains /
    Families
    for CD47 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD47 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR013270 CD47_Vset
     IPR007110 Ig-like_dom
     IPR006704 CD47
     IPR013147 CD47_TM

    Graphical View of Domain Structure for InterPro Entry Q08722

    ProtoNet protein and cluster: Q08722

    1 Blocks protein family: IPB006704 CD47 integrin associated protein

    UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for CD47 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
    Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the
    modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By
    similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits
    cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances
    superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane
    transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be
    involved in membrane permeability changes induced following virus infection

         Genatlas biochemistry entry for CD47:
    cell differentiation antigen 47,identified by monoclonal antibodies BRIC126,CIKM1,BRIC125,same as ovarian tumor marker
    OH3

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): CD47
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD47
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate CD47 (see all 53):
    hsa-miR-3678-3p hsa-miR-4307 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-548k hsa-miR-200a hsa-miR-374a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: CD47 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD47 (see all 7)
    OriGene shRNA RFP: CD47
    OriGene siRNA: CD47
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD47

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD47

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD47 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD47 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CD47 (NM_001777)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD47
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD47 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CD47
    Search LifeMap BioReagents cell lines for CD47

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD47

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15383453
    GO:0070053thrombospondin receptor activity IPI15700281


    CD47 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for CD47:
     Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory  Synthetic lethal with gemcitab  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Cd47tm1Fpl for CD47
         15 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cd47):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  muscle 
     nervous system  respiratory system  skeleton  tumorigenesis  vision/eye 

    CD47 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CD47 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    		Integrin Pathway1.00
    		Inhibition of Angiogenesis by TSP10.37
    2Cell surface interactions at the vascular wall
    		Cell surface interactions at the vascular wall1.00
    3A-beta Uptake & Degradation
    		A-beta Uptake & Degradation1.00
    4Integrins in angiogenesis
    		Integrins in angiogenesis1.00
    5ECM-receptor interaction
    		ECM-receptor interaction1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for CD47
        A-beta Uptake & Degradation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD47
        Inhibition of Angiogenesis by TSP1
    Integrin Pathway

    1 BioSystems Pathway for CD47 
        Integrins in angiogenesis

    4        Reactome Pathways for CD47
        Hemostasis
    Signal regulatory protein (SIRP) family interactions
    Cell-Cell communication
    Cell surface interactions at the vascular wall


    1         Kegg Pathway  (Kegg details for CD47):
        ECM-receptor interaction


    CD47 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD47

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for CD47 (Q087221, 3 ENSP000003553614) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRPGQ9P1W81, 3, ENSP000003055294EBI-1268321,EBI-1268284 I2D: score=1 STRING: ENSP00000305529
    SIRPAP783243, ENSP000003483074I2D: score=4 STRING: ENSP00000348307
    FASP254453, ENSP000003479794I2D: score=2 STRING: ENSP00000347979
    ITGAVP067563, ENSP000002610234I2D: score=2 STRING: ENSP00000261023
    EPB42P164523, ENSP000003002154I2D: score=1 STRING: ENSP00000300215
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway TAS8294396
    GO:0007596blood coagulation TAS--
    GO:0008228opsonization IEA--
    GO:0008284positive regulation of cell proliferation IDA15383453


    CD47 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD47 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD47 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD47
    10/18 Novoseek chemical compound relationships for CD47 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 52.3 32 11907074 (2), 19036072 (2), 11479293 (2), 14739297 (2) (see all 19)
    phosphatidylserine 51.3 28 18482179 (5), 16131383 (4), 16115138 (3), 19794081 (3) (see all 10)
    fmlp 43.3 3 11479293 (1), 7732016 (1), 16790999 (1)
    phosphatidylinositol 26 4 11479293 (1), 11792697 (1), 11707450 (1)
    curcumin 22 1 16219905 (1)
    fibrinogen 17.6 5 7662966 (2), 10429193 (1), 12393714 (1)
    ly294002 16.9 1 19643963 (1)
    calcium 4.61 7 8376355 (4)
    cholesterol 0 8 14966135 (2), 10444074 (1), 11306274 (1), 11114301 (1)
    gtp 0 2 10085089 (1)

    Search CenterWatch for drugs/clinical trials and news about CD47 

    Transcripts
    for CD47 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD47 gene (4 alternative transcripts): 
    NM_001777.3  NM_198793.2  NM_001025079.1  NM_001025080.1  

    Unigene Cluster for CD47:

    CD47 molecule
    Hs.446414  [show with all ESTs]
    Unigene Representative Sequence: NM_001777
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471694 ENST00000355354(uc003dwt.1 uc003dwv.1) ENST00000398258
    ENST00000517766 ENST00000361309

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): CD47
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD47
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate CD47 (see all 53):
    hsa-miR-3678-3p hsa-miR-4307 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-548k hsa-miR-200a hsa-miR-374a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmid: CD47 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD47 (see all 7)
    OriGene shRNA RFP: CD47
    OriGene siRNA: CD47
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD47
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD47 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD47 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CD47 (NM_001777)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD47
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD47 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD47
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD47
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD47
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD47

    Additional cDNA sequence: 

    AK096670.1 AK289813.1 BC010016.2 BC012884.1 BC037306.1 BC045593.1 BC053959.1 BT006907.1 
    BX640889.1 X69398.1 Z25521.1 

    24/27 DOTS entries (see all 27):

    DT.101984965  DT.87016030  DT.456233  DT.100845125  DT.91764987  DT.95319826  DT.87015104  DT.215784 
    DT.120862895  DT.87016031  DT.100845121  DT.120862946  DT.40294662  DT.97847088  DT.95319824  DT.100845136 
    DT.120862927  DT.100037041  DT.40132745  DT.40189407  DT.102830031  DT.120862885  DT.120862910  DT.120862943 

    24/456 AceView cDNA sequences (see all 456):

    C05259 AA443828 AI887612 BF036383 CR592842 BU686268 AA463483 BE348320 
    AI700535 CR623329 CR621937 D31589 AA376836 CR615658 AW952455 AL708216 
    BM831951 AK096670 AA235129 AA773711 CR601569 BF438962 AA953028 AI283110 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CD47 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
    SP1:                          -           -                                         -     -                     
    SP2:        -     -           -           -                                                                     
    SP3:                          -           -                                                                     
    SP4:                                                                                -     -     -               
    SP5:              -           -                                                                                 


    ECgene alternative splicing isoforms for CD47

    Expression
    for CD47 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD47 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTTGATGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CD47 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Spinal CordSpinal Floor PlateFloor Plate Cells Neural Ectoderm
    BrainThalamusBrain
    LiverLiver LobuleLiver
    Spinal CordSpinal Floor PlateSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Dorsal forebrain-like neurons (Generation of midbra...)Brain

    See CD47 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD47

    SOURCE GeneReport for Unigene cluster: Hs.446414

    UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
    Tissue specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially
    abundant in some epithelia and the brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD47: 
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD47
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD47
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD47
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD47
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD47

    Orthologs
    for CD47 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CD47 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cd471 , 5 CD47 antigen (Rh-related antigen, integrin-associated more1, 5 76.19(n)1
    70.76(a)1    		   16 (31.23 cM)5
    164231  NM_010581.31  NP_034711.11 
     498556185 
    chicken
    (Gallus gallus)    		 Aves CD471 CD47 molecule 51.79(n)
    37.71(a)    		   418408  NM_001004388.2  NP_001004388.2 


    ENSEMBL Gene Tree for CD47 (if available)
    TreeFam Gene Tree for CD47 (if available) 

    Paralogs
    for CD47 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD47 gene

    CD47 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD47
    PGOHUM00000242474


    Genomic Variants
    for CD47 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/715 NCBI SNPs in CD47 are shown (see all 715)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1441960621,2
    		--107761462(+) CATGCA/GCTCTT 2 -- ds50010--------
    rs1141683531,2
    		C,F,--107761471(+) TTTTTT/CACCCC 2 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1894756141,2
    		--107761564(+) CCACAC/TGAAGG 2 -- ds50010--------
    rs783345071,2
    		--107761700(+) GTTTTC/TTTTCA 2 -- ds50010--------
    rs1821770871,2
    		--107761794(+) AGAGAC/TGGACA 2 -- ds50010--------
    rs1858268851,2
    		--107761795(+) GAGACC/GGACAC 2 -- ds50010--------
    rs1909265491,2
    		--107761812(+) CCAGGA/GAAGTA 2 -- ds50010--------
    rs1412187291,2
    		--107761856(+) GCCAGA/GACTAG 2 -- ds50010--------
    rs1817305601,2
    		--107761867(+) CACCCA/GGGTCT 2 -- ds50010--------
    rs1433789941,2
    		--107762110(+) TTGTGA/GTCTGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CD47 (107761941 - 107809935 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CD47
         1 CNV: 98398
         2 Inversions: 0560 37238

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD47
    DNA2.0 Custom Variant and Variant Library Synthesis for CD47

    Disorders / Diseases
    for CD47 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD47 for disorders           About GeneDecksing

    OMIM gene information: 601028    OMIM disorders: --

    20/37 diseases for CD47 (see all 37):    About MalaCards
    glanzmann's thrombasthenia    inclusion body myositis    thrombasthenia    spherocytosis
    malignant pleural mesothelioma    autoimmune hemolytic anemia    hemolytic anemia    hereditary spherocytosis
    stem cell leukemia    neonatal meningitis    chronic lymphocytic leukemia    acute myeloid leukemia
    myositis    lymphocytic leukemia    myeloid leukemia    anemia
    meningitis    squamous cell carcinoma    multiple myeloma    t-cell leukemia

    2 diseases from the University of Copenhagen DISEASES database for CD47:
    Autoimmune hemolytic anemia     Hemolytic anemia

    10/18 Novoseek disease relationships for CD47 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glanzmann thrombasthenia 45.5 1 7662966 (1)
    spherocytosis hereditary 43.3 2 12176912 (1), 12393467 (1)
    anemia hemolytic 41.7 3 17163870 (2), 12393467 (1)
    erythroleukemia 25.2 3 11331301 (1), 7691831 (1), 7662966 (1)
    inflammation 24.4 4 17678954 (1), 7732016 (1), 19360900 (1), 19815354 (1)
    necrosis 22.6 7 9653098 (2), 15833768 (1), 7732016 (1), 17253597 (1) (see all 6)
    autoimmune diseases 19.4 2 15359629 (1), 11509584 (1)
    myeloma 13.4 1 15725479 (1)
    hemolysis 11.5 2 12393467 (1), 17163870 (1)
    melanoma 3.92 3 8896608 (1), 12924949 (1), 20161613 (1)


    Export disorders for CD47 gene to outside databases

    Publications
    for CD47 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD47 gene, integrated from 9 sources (see all 272):
    (articles sorted by number of sources associating them with CD47)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Rh-related antigen CD47 is the signal-transducer integrin-associated protein. (PubMed id 8294396)1, 3, 9 Lindberg F.P....Brown E.J. (1994)
    2. Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. (PubMed id 11454874)1, 2, 9 Rebres R.A.... Brown E.J. (2001)
    3. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. (PubMed id 18657508)1, 2, 9 Hatherley D....Barclay A.N. (2008)
    4. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. (PubMed id 10549293)1, 2, 9 Wu A.-L.... Brown E.J. (1999)
    5. Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. (PubMed id 7998989)1, 2, 9 Mawby W.J.... Tanner M.J.A. (1994)
    6. Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding. (PubMed id 7691831)1, 2, 9 Lindberg F.P.... Brown E.J. (1993)
    7. Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down- regulation of IL-12 responsiveness and inhibition of dendritic cell activation. (PubMed id 11509594)1, 2, 9 Latour S.... Sarfati M. (2001)
    8. Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. (PubMed id 15383453)1, 2 Piccio L.... Colonna M. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)

    External Searches for CD47 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CD47 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 961 HGNC: 1682 AceView: CD47 Ensembl:ENSG00000196776 euGenes: HUgn961
    ECgene: CD47 Kegg: 961 H-InvDB: CD47

    Other Databases showing CD47 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD47 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD47 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD47 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CD47 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD47 gene:
    Search GeneIP for patents involving CD47

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CD47 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CD47 (CD47)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for CD47 (CD47)  
     OriGene Antibodies for CD47   OriGene shRNA RFP for CD47  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD47   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD47  
     OriGene Protein Over-expression Lysate for CD47   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CD47   OriGene 3'-UTR Clone for CD47  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD47   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD47  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD47   OriGene Custom Protein Services for CD47  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD47
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD47
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD47
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD47
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD47
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD47
     GenScript Custom Purified and Recombinant Proteins Services for CD47 GenScript cDNA clones with any tag delivered in your preferred vector for CD47
     GenScript Custom Assay Services for CD47 GenScript Custom Superior Antibodies Services for CD47
     GenScript Custom overexpressing Cell Line Services for CD47 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CD47 promoter
     Search Chromatin IP Primers for CD47
     RT2 qPCR Primer Assay in human, mouse, rat CD47
     GNC Network for CD47
     SABiosciences PCR Arrays including human, mouse, rat CD47
     Search Tocris compounds for CD47
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CD47 antibodies
     CD47 proteins
     CD47 lysates
     Antibodies for CD47
     See all of Abcam's Antibodies, Kits and Proteins for CD47
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CD47 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CD47
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD47
     SwitchGear 3'UTR luciferase reporter plasmids for CD47
     SwitchGear Promoter luciferase reporter plasmids for CD47
     ThermoFisher Antibody for CD47
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD47
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CD47 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4