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Aliases for CD47 Gene

Aliases for CD47 Gene

  • CD47 Molecule 2 3 5
  • Antigenic Surface Determinant Protein OA3 2 3 4
  • CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer) 2 3
  • Antigen Identified By Monoclonal Antibody 1D8 2 3
  • Leukocyte Surface Antigen CD47 2 3
  • Integrin Associated Protein 2 3
  • Rh-Related Antigen 2 3
  • CD47 Glycoprotein 2 3
  • MER6 3 4
  • IAP 3 4
  • Integrin-Associated Signal Transducer 3
  • Integrin-Associated Protein 4
  • CD47 Antigen 4
  • Protein MER6 4
  • OA3 3

External Ids for CD47 Gene

Previous HGNC Symbols for CD47 Gene

  • MER6

Previous GeneCards Identifiers for CD47 Gene

  • GC03M104559
  • GC03M107293
  • GC03M109043
  • GC03M109086
  • GC03M109083
  • GC03M109244
  • GC03M107761
  • GC03M105135

Summaries for CD47 Gene

Entrez Gene Summary for CD47 Gene

  • This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for CD47 Gene

CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Neonatal Meningitis and Hereditary Spherocytosis. Among its related pathways are Immune System and Cell surface interactions at the vascular wall. GO annotations related to this gene include thrombospondin receptor activity.

UniProtKB/Swiss-Prot for CD47 Gene

  • Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Gene Wiki entry for CD47 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD47 Gene

Genomics for CD47 Gene

Regulatory Elements for CD47 Gene

Enhancers for CD47 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F108123 1.2 FANTOM5 ENCODE 13 -35.0 -35017 6.2 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A YBX1 ZNF2 YY1 GATA2 ZNF207 CD47 IFT57 MYH15 DZIP3 GC03M108125 LINC01215
GH03F108083 0.3 FANTOM5 10 +7.4 7380 0.3 CD47 HHLA2 MYH15 GC03M108067
GH03F108087 1.2 FANTOM5 ENCODE 9.5 +0.9 871 6.2 SIN3A YY1 CBX5 ZNF143 ZNF207 ZNF202 JUNB TBX21 SMARCB1 SMARCA4 CD47 MYH15 GC03M108067
GH03F108096 0.9 Ensembl ENCODE 9 -8.9 -8904 7.2 PKNOX1 ATF1 WRNIP1 YY1 GATA2 CBX5 JUNB REST TBX21 MEF2D IFT57 CD47 LOC105374031 LINC01215
GH03F108153 0.5 Ensembl 8.7 -62.4 -62414 0.6 ZNF664 CTCF ZNF654 CEBPB SMC3 REST ZNF2 RAD21 SPI1 CD47 GC03M108125 IFT57
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CD47 on UCSC Golden Path with GeneCards custom track

Promoters for CD47 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001370323 1288 4001 YY1 CBX5 ZNF143 ZNF207 ZNF202 JUNB TBX21 SMARCB1 SMARCA4 GLIS1

Genomic Location for CD47 Gene

Chromosome:
3
Start:
108,043,094 bp from pter
End:
108,091,088 bp from pter
Size:
47,995 bases
Orientation:
Minus strand

Genomic View for CD47 Gene

Genes around CD47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD47 Gene

Proteins for CD47 Gene

  • Protein details for CD47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08722-CD47_HUMAN
    Recommended name:
    Leukocyte surface antigen CD47
    Protein Accession:
    Q08722
    Secondary Accessions:
    • A8K198
    • D3DN59
    • Q53Y71
    • Q96A60

    Protein attributes for CD47 Gene

    Size:
    323 amino acids
    Molecular mass:
    35214 Da
    Quaternary structure:
    • Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2.

    Three dimensional structures from OCA and Proteopedia for CD47 Gene

    Alternative splice isoforms for CD47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD47 Gene

Post-translational modifications for CD47 Gene

  • Ubiquitination at Lys 74, Lys 93, Lys 314, and Lys 317
  • Glycosylation at Asn 23, Asn 34, Asn 50, Asn 73, Asn 111, and Asn 206
  • Modification sites at PhosphoSitePlus

Other Protein References for CD47 Gene

No data available for DME Specific Peptides for CD47 Gene

Domains & Families for CD47 Gene

Protein Domains for CD47 Gene

Suggested Antigen Peptide Sequences for CD47 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08722

UniProtKB/Swiss-Prot:

CD47_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD47: view

Function for CD47 Gene

Molecular function for CD47 Gene

GENATLAS Biochemistry:
cell differentiation antigen 47,identified by monoclonal antibodies BRIC126,CIKM1,BRIC125,same as ovarian tumor marker OH3
UniProtKB/Swiss-Prot Function:
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Gene Ontology (GO) - Molecular Function for CD47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15383453
GO:0070053 thrombospondin receptor activity IPI 15700281
genes like me logo Genes that share ontologies with CD47: view
genes like me logo Genes that share phenotypes with CD47: view

Animal Models for CD47 Gene

MGI Knock Outs for CD47:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD47

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD47 Gene

Localization for CD47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD47 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD47 Gene COMPARTMENTS Subcellular localization image for CD47 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
golgi apparatus 2
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CD47: view

Pathways & Interactions for CD47 Gene

genes like me logo Genes that share pathways with CD47: view

Pathways by source for CD47 Gene

SIGNOR curated interactions for CD47 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007229 integrin-mediated signaling pathway TAS 8294396
GO:0008228 opsonization IEA --
GO:0008284 positive regulation of cell proliferation IDA 15383453
GO:0009617 response to bacterium IEA --
genes like me logo Genes that share ontologies with CD47: view

Drugs & Compounds for CD47 Gene

(19) Drugs for CD47 Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
rituximab Approved Pharma Therapeutic Antibodies 1654
Trastuzumab Approved, Investigational Pharma HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 766
ABT-510 Investigational Pharma 0
Antibodies Pharma 6045
Antibodies, Monoclonal Pharma 3795

(6) Additional Compounds for CD47 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD47: view

Transcripts for CD47 Gene

Unigene Clusters for CD47 Gene

CD47 molecule:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD47

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD47 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for CD47 Gene

GeneLoc Exon Structure for
CD47
ECgene alternative splicing isoforms for
CD47

Expression for CD47 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD47 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD47 Gene

This gene is overexpressed in Nasal epithelium (20.2) and Platelet (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD47 Gene



Protein tissue co-expression partners for CD47 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD47 Gene:

CD47

SOURCE GeneReport for Unigene cluster for CD47 Gene:

Hs.446414

mRNA Expression by UniProt/SwissProt for CD47 Gene:

Q08722-CD47_HUMAN
Tissue specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
genes like me logo Genes that share expression patterns with CD47: view

Primer Products

No data available for mRNA differential expression in normal tissues for CD47 Gene

Orthologs for CD47 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD47 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia CD47 34 35
  • 80.62 (n)
cow
(Bos Taurus)
Mammalia CD47 34 35
  • 79.62 (n)
mouse
(Mus musculus)
Mammalia Cd47 34 16 35
  • 76.16 (n)
rat
(Rattus norvegicus)
Mammalia Cd47 34
  • 75.06 (n)
oppossum
(Monodelphis domestica)
Mammalia CD47 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD47 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD47 34 35
  • 51.79 (n)
lizard
(Anolis carolinensis)
Reptilia CD47 35
  • 37 (a)
OneToOne
Species where no ortholog for CD47 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD47 Gene

ENSEMBL:
Gene Tree for CD47 (if available)
TreeFam:
Gene Tree for CD47 (if available)

Paralogs for CD47 Gene

Pseudogenes.org Pseudogenes for CD47 Gene

genes like me logo Genes that share paralogs with CD47: view

No data available for Paralogs for CD47 Gene

Variants for CD47 Gene

Sequence variations from dbSNP and Humsavar for CD47 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1051050 -- 108,047,741(-) TACAG(A/T)ATGTC intron-variant
rs1063570 -- 108,052,478(-) TGAGT(A/G)TTTTC intron-variant
rs10933931 -- 108,068,678(+) CAAAA(C/T)GGGAA intron-variant
rs11083 -- 108,058,362(-) GCTGT(A/G)GTTGG nc-transcript-variant, reference, synonymous-codon
rs111345106 -- 108,056,422(+) AAGAA(C/T)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD47 Gene

Variant ID Type Subtype PubMed ID
esv2633277 CNV deletion 19546169
nsv1011158 CNV gain 25217958
nsv241 OTHER inversion 15895083
nsv7355 OTHER inversion 18451855
nsv953243 CNV duplication 24416366

Variation tolerance for CD47 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 9.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD47 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD47 Gene

Disorders for CD47 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CD47 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neonatal meningitis
  • meningitis, neonatal
hereditary spherocytosis
  • congenital spherocytic hemolytic anemia
retinohepatoendocrinologic syndrome
  • rh deficiency syndrome
chronic laryngitis
- elite association - COSMIC cancer census association via MalaCards
Search CD47 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD47

Genetic Association Database (GAD)
CD47
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD47
genes like me logo Genes that share disorders with CD47: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD47 Gene

Publications for CD47 Gene

  1. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. (PMID: 18657508) Hatherley D. … Barclay A.N. (Mol. Cell 2008) 3 4 22 64
  2. Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. (PMID: 11454874) Rebres R.A. … Brown E.J. (J. Biol. Chem. 2001) 3 4 22 64
  3. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. (PMID: 10549293) Wu A.-L. … Brown E.J. (Mol. Cell 1999) 3 4 22 64
  4. Rh-related antigen CD47 is the signal-transducer integrin-associated protein. (PMID: 8294396) Lindberg F.P. … Brown E.J. (J. Biol. Chem. 1994) 2 3 22 64
  5. Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. (PMID: 7998989) Mawby W.J. … Tanner M.J.A. (Biochem. J. 1994) 3 4 22 64

Products for CD47 Gene

Sources for CD47 Gene

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