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CD47 Gene

protein-coding   GIFtS: 63

GC03M109244
CD47 molecule
(Previous names: CD47 antigen (Rh-related antigen, integrin-associated signal transducer) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MER6)
Services    

Aliases &
Descriptions
for CD47

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
IAP 1, 2, 3, 5
MER6 2, 3, 5
OA3 1, 2
Descriptions
Antigenic surface determinant protein OA3 2, 3
CD47 antigen 2, 3
CD47 antigen (Rh-related antigen, integrin-associated
signal transducer) 1, 2
CD47 glycoprotein 2
CD47 molecule 2
Integrin-associated protein 3
Protein MER6 3
Rh-related antigen 2
antigen identified by monoclonal antibody 1D8 2
integrin associated protein 2
integrin-associated signal transducer 2
leukocyte surface antigen CD47 2
External Ids
HGNC: 16821
Entrez Gene: 9612
UniProtKB: Q087223
Ensembl: ENSG000001967767
Search outside databases for aliases for CD47 gene

Previous GC identifers: GC03M104559 GC03M107293 GC03M109043 GC03M109086 GC03M109083

Summaries
for CD47

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for CD47:
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium
concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also
a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in
membrane transport and signal transduction. This gene has broad tissue distribution, and is
reduced in expression on Rh erythrocytes. Four alternatively spliced transcript variants encoding
distinct isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on
platelets, and in the modulation of integrins. Plays an important role in memory formation and
synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which
prevents maturation of immature dendritic cells and inhibits cytokine production by mature
dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances
superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play
a role in membrane transport and/or integrin dependent signal transduction. May prevent premature
elimination of red blood cells. May be involved in membrane permeability changes induced following
virus infection

Gene Wiki entry for CD47

Genomic Location
for CD47

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CD47 gene  

Entrez Gene cytogenetic band: 3q13.1-q13.2   Ensembl cytogenetic band:  3q13.12   HGNC cytogenetic band: 3q13.1-q13.2

CD47 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M109244:     (about GC identifiers)

Start:
 109,244,631 bp from pter
End:
 109,292,629 bp from pter
Size:
 47,999 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  

Proteins
for CD47

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722 (See protein sequence)
Recommended Name: Leukocyte surface antigen CD47 precursor  
Size: 323 amino acids; 35214 Da
Subunit: Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG,
UBQLN1 and UBQLN2
Subcellular location: Cell membrane; Multi-pass membrane protein
PDB structures from and Proteopedia :
2JJS (3D)    2JJT (3D)    2VSC (3D)    
Secondary accessions: Q53Y71 Q96A60
Alternative splicing: 4 isoforms:  Q08722-1   Q08722-2   Q08722-3   Q08722-4   

REFSEQ proteins (3 alternative transcripts): 
NP_001020250.1  NP_001768.1  NP_942088.1  


ENSEMBL proteins: 
ENSP00000381309 ENSP00000381308 ENSP00000347512 ENSP00000355361 ENSP00000381310 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (CD47)
Human Recombinant Proteins from Abnova (CD47)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS10429193
GO:0005887 integral to plasma membrane TAS7998989
About this table

Antibodies for CD47: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of CD47
Browse Antibodies at Sigma-Aldrich
R&D Systems Antibodies for CD47
Antibodies from Abcam (CD47), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (CD47)
Novus Biologicals Antibodies for CD47

Assays for CD47: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for CD47

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro domains/families:
 IPR013270 CD47_Vset
 IPR007110 Ig-like
 IPR006704 CD47
 IPR013147 CD47_TM


   GeneDecks  CD47 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q08722

ProtoNet protein and cluster: Q08722

1 Blocks protein family: IPB006704 CD47 integrin associated protein

UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

Gene Function
for CD47

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (CD47)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001025079

              Applied Biosystems Silencer® siRNAs for CD47

              Sigma-Aldrich siRNA and siRNA Panels for CD47  
                     Sigma-Aldrich shRNA Panels and shRNA for CD47  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for CD47
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001025079
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001025079
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001025079 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001777

UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on
platelets, and in the modulation of integrins. Plays an important role in memory formation and
synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which
prevents maturation of immature dendritic cells and inhibits cytokine production by mature
dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances
superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play
a role in membrane transport and/or integrin dependent signal transduction. May prevent premature
elimination of red blood cells. May be involved in membrane permeability changes induced following
virus infection

Genatlas biochemistry entry for CD47:
cell differentiation antigen 47,identified by monoclonal antibodies BRIC126,CIKM1,BRIC125,same as
ovarian tumor marker OH3

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cd47):

hematopoietic systemimmune systemnormal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IPI15383453
GO:0070053 thrombospondin receptor activity IPI15700281
About this table

Pathways & Interactions
for CD47

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Invitrogen iPath™ Online BioAtlas - Pathway for CD47 (Maps provided by GeneGo):
 Receptors. Part D. IL4R-pleckstrin homology proteins interactions

   GeneDecks  CD47 for the pathways selected above  
About GeneDecksing

1 Kegg Pathway  (Kegg details for CD47):
 hsa04512 ECM-receptor interaction

   GeneDecks  CD47 for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  CD47 


5/37 Interacting proteins for CD47 (ENSP000003553613) via UniProtKB, MINT, and/or STRING (see all 37 )
InteractantInteraction Details
GeneCardExternal ID(s)
SIRPAENSP000003483073STRING (score=.999)
THBS1ENSP000002603563STRING (score=.999)
SIRPGENSP000003055293STRING (score=.995)
ITGAVENSP000003640423STRING (score=.989)
SIRPB1ENSP000003710123STRING (score=.985)
About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007155 cell adhesion IEA--
GO:0007229 integrin-mediated signaling pathway TAS8294396
GO:0008284 positive regulation of cell proliferation IDA15383453
GO:0022409 positive regulation of cell-cell adhesion IDA15383453
GO:0050870 positive regulation of T cell activation IDA15383453
About this table

Drugs & Compounds
for CD47

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CD47
9 Novoseek chemical compound relationships for CD47 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine 54.10 32 11907074 (2), 19036072 (2), 11479293 (2), 14739297 (2) (see all 19)
fmlp 35.16 3 11479293 (1), 7732016 (1), 16790999 (1)
phosphatidylinositol 28.02 4 11479293 (1), 11792697 (1), 11707450 (1)
fibrinogen 19.69 5 7662966 (2), 10429193 (1), 12393714 (1)
calcium 5.02 7 8376355 (4)
oxygen 0.00 1 14585540 (1)
nitric oxide 0.00 7 18193160 (2), 16055727 (1), 18156939 (1), 18187671 (1)
cholesterol 0.00 8 14966135 (2), 10444074 (1), 11306274 (1), 11114301 (1)
gtp 0.00 2 10085089 (1)
About this table


Transcripts
for CD47

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (CD47)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001025079

              Sigma-Aldrich siRNA and siRNA Panels for CD47  
                     Sigma-Aldrich shRNA Panels and shRNA for CD47  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001025079  NM_001777  NM_198793  

REFSEQ mRNAs for CD47 gene (3 alternative transcripts): 

NM_001025079.1   NM_001777.3   NM_198793.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001025079  NM_001777  NM_198793  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001025079
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001025079
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001025079 

Additional cDNA sequence: 

AK096670.1 AK289813.1 BC010016.2 BC012884.1 BC037306.1 BC045593.1 BC053959.1 BT006907.1 
BX640889.1 CR591693.1 CR591788.1 CR592842.1 CR601569.1 CR615658.1 CR621937.1 CR623329.1 
CR624381.1 X69398.1 Z25521.1 

24/27 DOTS entries (see all 27 ):

DT.101984965  DT.87016030  DT.456233  DT.100845125  DT.95319826  DT.91764987  DT.87015104  DT.215784 
DT.120862895  DT.87016031  DT.100845121  DT.95319824  DT.120862946  DT.40294662  DT.97847088  DT.100845136 
DT.120862927  DT.40189407  DT.100037041  DT.40132745  DT.102830031  DT.120862885  DT.120862910  DT.120862943 

24/456 AceView cDNA sequences (see all 456 ):

BX953191 AI884496 BX471206 BQ049048 AW952455 AA443828 BU686268 T39172 
AI700535 AW276245 CR621937 AI476785 AL700103 AA953028 CR591693 D31589 
AA969906 CF128363 CR601569 CB068304 AI742309 BT006907 AA383529 NM_001777 

highest scoring ESTs for CD47:

X69398 AL118798 AL529893 AL552279 AU142804 AW817309 BC010016 BC012884 BC037306 BE271711 

Unigene Cluster for CD47:

CD47 molecule
Hs.446414  [show with all ESTs]
Unigene Representative Sequence: NM_001777


GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CD47 (see all 8 )

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1:                          -           -                                         -     -                     
SP2:        -     -           -           -                                                                     
SP3:                          -           -                                                                     
SP4:                                                                                -     -     -               
SP5:              -           -                                                                                 

About this scheme

ECgene alternative splicing isoforms for CD47

5 Ensembl transcripts including schematic representations:
ENST00000398258  ENST00000398257  ENST00000355354  ENST00000361309  ENST00000398260  

Expression
for CD47

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CD47 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for CD47

1 / 2 / 3

14 probe-sets matching CD47 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
61356_at2, 3 U95-C 1 1.00 1.00 0.87 0.83 AA443174 0.40 1.00 0.76 1

54922_at2, 3 U95-B 1 1.00 1.00 0.86 1.40 AL118798 0.80 1.00 0.91 1
37890_at2, 3 U95-A 1 1.00 1.00 0.73 0.96 X69398 1.00 1.00 1.00 1
87790_at2, 3 U95-E 1 1.00 1.00 0.89 0.85 AW015585 0.60 1.00 0.82 1

213055_at2, 3 U133-A 1 1.00 1.00 -- -- BF693956 0.40 1.00 0.76 1

213857_s_at2, 3 U133-A 1 1.00 1.00 -- -- BG230614 0.20 1.00 0.72 1

226016_at2, 3 U133-B 1 1.00 1.00 -- -- AL118798 0.80 1.00 0.91 1

211075_s_at2, 3 U133-A 1 1.00 1.00 -- -- Z25521 0.80 1.00 0.91 1

227259_at2, 3 U133-B 1 1.00 1.00 -- -- BF439618 0.40 1.00 0.76 1

213055_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

213857_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

226016_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

211075_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

227259_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  CD47 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GCCTTGATGA

SOURCE GeneReport for Unigene cluster: Hs.446414

Expression variation in blood from EXPOLDB for CD47

UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
Tissue specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors,
being especially abundant in some epithelia and the brain

Orthologs
for CD47

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for CD47 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 CD471   -- CD47 molecule 81.26(n)
71.9(a)		 478552  XM_535729.2  XP_535729.2 
chimpanzee
(Pan troglodytes)		 CD471   -- CD47 molecule 99.46(n)
99.02(a)		 460569  XM_516636.2  XP_516636.2 
cow
(Bos taurus)		 CD471   -- CD47 molecule 79.62(n)
71.43(a)		 282661  NM_174708.2  NP_777133.2 
rat
(Rattus norvegicus)		 Cd471   -- Cd47 molecule 75.08(n)
71.1(a)		 29364  NM_019195.2  NP_062068.1 
mouse
(Mus musculus)		 Cd471, 5 165
 CD47 antigen (Rh-related antigen, integrin-associated more1, 5 76.19(n)1
70.76(a)1		 164231  NM_010581.31  NP_034711.11 
 AA4078625  AB0126935  (see all 17)
About this table        Species with no ortholog for CD47

ENSEMBL Gene Tree for CD47

Paralogs
for CD47

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for CD47

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/200 NCBI SNPs in CD47 are shown (see all 200 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 93)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 3 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs3263411,2
A,C,F,H109293832(+) CCAGCG/ATATGA 3 -- ng315Minor allele frequency- A:0.37EU EA WA 1912
rs98799471,2
A,C,F,H109248082(+) AGCAAG/ATAACA 3 -- ut31 ese34Minor allele frequency- A:0.37EU EA WA 418
rs22710541,2
C,F,H109245730(+) AGATGG/AAGGAG 3 -- ut31 ese38Minor allele frequency- A:0.03EA NA EU WA 2040
rs37626811,2
C,F,H109294477(+) ACCTGG/AGTGAC 3 -- ng319Minor allele frequency- A:0.13EA EU WA 2302
rs67811001,2
A,C109245997(+) AAAAAA/CCAGAA 3 -- ut31 trp30--------
rs32066521,2
C,F109247939(-) GTTGTA/GACATA 3 -- ut311Minor allele frequency- G:0.20MN 184
rs98226211,2
H109246346(+) TTGCAG/AAAAAG 3 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 414
--
rs76123561,2
A109293727(+) TACCTC/GCTGGG 3 -- ng31 tfbs30--------
--
rs4455411,2
C109292488(+) GTGTCC/TGGAGC 3 -- ut51 ese30--------
--
rs115466461,2
H109281642(-) GAGATG/CCCTCT 3 P/A mis1 ese34Minor allele frequency- C:0.00EU EA WA 370
About this table

HapMap Linkage Disequilibrium images for CD47 (up to first 250kb)

Disorders & Mutations
for CD47

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 601028

10/18 Novoseek disease relationships for CD47 gene (see all 18 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
glanzmann thrombasthenia 47.22 1 7662966 (1)
spherocytosis hereditary 45.00 2 12176912 (1), 12393467 (1)
anemia hemolytic 39.15 3 17163870 (2), 12393467 (1)
erythroleukemia 26.72 3 11331301 (1), 7691831 (1), 7662966 (1)
necrosis 25.14 7 9653098 (2), 15833768 (1), 7732016 (1), 17253597 (1) (see all 6)
inflammation 19.83 2 17678954 (1), 7732016 (1)
autoimmune diseases 18.24 2 15359629 (1), 11509584 (1)
hemolysis 13.71 2 12393467 (1), 17163870 (1)
myeloma 6.06 1 15725479 (1)
breast cancer 4.38 1 14871834 (1)
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1 PharmGKB disease relationship for CD47 gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1FA  GN  12730115
About this table

Medical News
for CD47

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for CD47

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/221 PubMed articles for CD47 gene (see all 221 ):

Search for CD47

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing CD47

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 961 HGNC: 1682 AceView: CD47 Ensembl:ENSG00000196776 euGenes: HUgn961
ECgene: CD47 H-InvDB: CD47

Other Databases showing CD47

(According to HUGE)
About This Section

   --

Specialized Databases showing CD47

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for CD47 Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies
for CD47

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for CD47

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for CD47:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for CD47-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for CD47 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for CD47 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (CD47)
 Antibodies (CD47)
 Search for Chimera RNAi
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(CD47)
 Antibodies (CD47)
 Search OriGene for CD47
 Search Tocris compounds for CD47




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for CD47

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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CD47 Gene at Home site.
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