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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD47 Gene

protein-coding   GIFtS: 61
GCID: GC03M107761

CD47 Molecule

(Previous names: CD47 antigen (Rh-related antigen, integrin-associated signal...)
(Previous symbol: MER6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD47 Molecule1 2     Leukocyte Surface Antigen CD471 2
MER61 2 3 5     Rh-Related Antigen1 2
Antigenic Surface Determinant Protein OA31 2 3     Integrin-Associated Protein2 3
IAP2 3 5     OA32
CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer)1 2     Integrin-Associated Signal Transducer2
Antigen Identified By Monoclonal Antibody 1D81 2     CD47 Antigen3
CD47 Glycoprotein1 2     Protein MER63
Integrin Associated Protein1 2     

External Ids:    HGNC: 16821   Entrez Gene: 9612   Ensembl: ENSG000001967767   OMIM: 6010285   UniProtKB: Q087223   

Export aliases for CD47 gene to outside databases

Previous GC identifers: GC03M104559 GC03M107293 GC03M109043 GC03M109086 GC03M109083 GC03M109244 GC03M105135


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD47 Gene:
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration
that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal
cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This
gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for CD47 Gene: 
CD47 (CD47 molecule) is a protein-coding gene. Diseases associated with CD47 include neonatal meningitis, and stem cell leukemia, and among its related super-pathways are FAK1 Signaling and Cell junction organization. GO annotations related to this gene include protein binding and thrombospondin receptor activity.

UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the
modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus
(By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and
inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion,
enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role
in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red
blood cells. May be involved in membrane permeability changes induced following virus infection

Gene Wiki entry for CD47 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD47 gene promoter:
         ER-alpha   AML1a   FOXL1   HEN1   c-Myb   NF-kappaB1   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD47 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD47

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD47


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.1-q13.2   Ensembl cytogenetic band:  3q13.12   HGNC cytogenetic band: 3q13.1-q13.2

CD47 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD47 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M107761:  view genomic region     (about GC identifiers)

Start:
107,761,941 bp from pter      End:
107,809,935 bp from pter
Size:
47,995 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722 (See protein sequence)
Recommended Name: Leukocyte surface antigen CD47 precursor  
Size: 323 amino acids; 35214 Da
Subunit: Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and
UBQLN2
Subcellular location: Cell membrane; Multi-pass membrane protein
4 PDB 3D structures from and Proteopedia for CD47:
2JJS (3D)        2JJT (3D)        2VSC (3D)        4KJY (3D)    
Secondary accessions: A8K198 D3DN59 Q53Y71 Q96A60
Alternative splicing: 4 isoforms:  Q08722-1   Q08722-2   Q08722-3   Q08722-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CD47: NX_Q08722

Explore proteomics data for CD47 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q08722

  • CD47 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD47 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001768.1  NP_942088.1  

    ENSEMBL proteins: 
     ENSP00000347512   ENSP00000381309   ENSP00000430843   ENSP00000355361  
    Reactome Protein details: Q08722
    Human Recombinant Protein Products for CD47: 
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    Novus Biologicals CD47 Proteins
    Novus Biologicals CD47 Lysates
    Sino Biological Recombinant Protein for CD47
    Sino Biological Cell Lysate for CD47 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IEA--

    CD47 for ontologies           About GeneDecksing



    CD47 Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013270 CD47_Vset
     IPR007110 Ig-like_dom
     IPR006704 CD47
     IPR013147 CD47_TM

    Graphical View of Domain Structure for InterPro Entry Q08722

    ProtoNet protein and cluster: Q08722

    1 Blocks protein domain: IPB006704 CD47 integrin associated protein

    UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD47 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD47_HUMAN, Q08722
    Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the
    modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus
    (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and
    inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion,
    enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role
    in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red
    blood cells. May be involved in membrane permeability changes induced following virus infection

         Genatlas biochemistry entry for CD47:
    cell differentiation antigen 47,identified by monoclonal antibodies BRIC126,CIKM1,BRIC125,same as ovarian tumor
    marker OH3

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15383453
    GO:0070053thrombospondin receptor activity IPI15700281
         
    CD47 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CD47:
     Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory  Synthetic lethal with gemcitab  Upregulation of Wnt/beta-caten 

         15 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd47):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  muscle 
     nervous system  respiratory system  skeleton  tumorigenesis  vision/eye 

    CD47 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd47tm1Fpl for CD47

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD47 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD47

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD47 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD47 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCD47 3' UTR sequence
    Inhib. RNA
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    Clone
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    Sino Biological Human cDNA Clone for CD47
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                         Customized lentivirus expression plasmids for stable overexpression of CD47 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD47


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD47 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    2Cell-cell junction organization
    Cell-Cell communication0.64
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    4Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    5Spinal Cord Injury
    Spinal Cord Injury

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CD47
        A-beta Uptake & Degradation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD47
        Inhibition of Angiogenesis by TSP1
    Integrin Pathway

    2 BioSystems Pathways for CD47
        Spinal Cord Injury
    Integrins in angiogenesis


    4        Reactome Pathways for CD47
        Hemostasis
    Signal regulatory protein (SIRP) family interactions
    Cell-Cell communication
    Cell surface interactions at the vascular wall


    1         Kegg Pathway  (Kegg details for CD47):
        ECM-receptor interaction


    CD47 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD47

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for CD47 (Q087221, 3 ENSP000003553614) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRPGQ9P1W81, 3, ENSP000003055294EBI-1268321,EBI-1268284 I2D: score=1 STRING: ENSP00000305529
    SIRPAP783243, ENSP000003483074I2D: score=4 STRING: ENSP00000348307
    FASP254453, ENSP000003479794I2D: score=2 STRING: ENSP00000347979
    ITGAVP067563, ENSP000002610234I2D: score=2 STRING: ENSP00000261023
    EPB42P164523, ENSP000003002154I2D: score=1 STRING: ENSP00000300215
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway TAS8294396
    GO:0007596blood coagulation TAS--
    GO:0008228opsonization IEA--
    GO:0008284positive regulation of cell proliferation IDA15383453

    CD47 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD47 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD47

    10/18 Novoseek inferred chemical compound relationships for CD47 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 52.3 32 11907074 (2), 19036072 (2), 11479293 (2), 14739297 (2) (see all 19)
    phosphatidylserine 51.3 28 18482179 (5), 16131383 (4), 16115138 (3), 19794081 (3) (see all 10)
    fmlp 43.3 3 11479293 (1), 7732016 (1), 16790999 (1)
    phosphatidylinositol 26 4 11479293 (1), 11792697 (1), 11707450 (1)
    curcumin 22 1 16219905 (1)
    fibrinogen 17.6 5 7662966 (2), 10429193 (1), 12393714 (1)
    ly294002 16.9 1 19643963 (1)
    calcium 4.61 7 8376355 (4)
    cholesterol 0 8 14966135 (2), 10444074 (1), 11306274 (1), 11114301 (1)
    gtp 0 2 10085089 (1)

    Search CenterWatch for drugs/clinical trials and news about CD47

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD47 gene (4 alternative transcripts): 
    NM_001777.3  NM_198793.2  NM_001025079.1  NM_001025080.1  

    Unigene Cluster for CD47:

    CD47 molecule
    Hs.446414  [show with all ESTs]
    Unigene Representative Sequence: NM_001777
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471694 ENST00000355354(uc003dwt.1 uc003dwv.1) ENST00000398258
    ENST00000517766 ENST00000361309

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    hsa-miR-3678-3p hsa-miR-4307 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-548k hsa-miR-200a hsa-miR-374a hsa-miR-578
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    Additional mRNA sequence: 

    AK096670.1 AK289813.1 BC010016.2 BC012884.1 BC037306.1 BC045593.1 BC053959.1 BT006907.1 
    BX640889.1 X69398.1 Z25521.1 

    24/27 DOTS entries (see all 27):

    DT.101984965  DT.87016030  DT.456233  DT.100845125  DT.91764987  DT.95319826  DT.87015104  DT.215784 
    DT.120862895  DT.87016031  DT.100845121  DT.120862946  DT.40294662  DT.97847088  DT.95319824  DT.100845136 
    DT.120862927  DT.100037041  DT.40132745  DT.40189407  DT.102830031  DT.120862885  DT.120862910  DT.120862943 

    24/456 AceView cDNA sequences (see all 456):

    C05259 NM_198793 CR621937 BM831951 CR591788 AA478755 AA625761 BF036383 
    BM676392 AI923277 AI932456 BF439618 AA383529 AA234955 AA765954 BX105659 
    AA251087 CR615658 CR592842 D81879 BM968847 CF128857 T39172 CK430027 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CD47 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
    SP1:                          -           -                                         -     -                     
    SP2:        -     -           -           -                                                                     
    SP3:                          -           -                                                                     
    SP4:                                                                                -     -     -               
    SP5:              -           -                                                                                 


    ECgene alternative splicing isoforms for CD47

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD47 expression in normal human tissues (normalized intensities)      CD47 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTGATGA
    CD47 Expression
    About this image


    CD47 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Floor Plate Cells Spinal Floor Plate
             Spinal Floor Plate
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Limbal epithelial stem cells
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Blood (Hematopoietic System)
             hematopoietic stem cells   

    See CD47 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD47

    SOURCE GeneReport for Unigene cluster: Hs.446414

    UniProtKB/Swiss-Prot: CD47_HUMAN, Q08722
    Tissue specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially
    abundant in some epithelia and the brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD47: 
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD47 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd471 , 5 CD47 antigen (Rh-related antigen, integrin-associated more1, 5 76.19(n)1
    70.76(a)1
      16 (31.23 cM)5
    164231  NM_010581.31  NP_034711.11 
     498556185 
    chicken
    (Gallus gallus)
    Aves CD471 CD47 molecule 51.79(n)
    37.71(a)
      418408  NM_001004388.2  NP_001004388.2 
    lizard
    (Anolis carolinensis)
    Reptilia CD476
    CD47 molecule
    37(a)
    1 ↔ 1
    3(169556022-169641506)


    ENSEMBL Gene Tree for CD47 (if available)
    TreeFam Gene Tree for CD47 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD47 gene

    CD47 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CD47
    PGOHUM00000242474


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/863 SNPs in CD47 are shown (see all 863)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441960621,2
    --107761462(+) CATGCA/GCTCTT 2 -- ds50010--------
    rs1141683531,2
    C,F--107761471(+) TTTTTT/CACCCC 2 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1894756141,2
    --107761564(+) CCACAC/TGAAGG 2 -- ds50010--------
    rs783345071,2
    --107761700(+) GTTTTC/TTTTCA 2 -- ds50010--------
    rs1821770871,2
    --107761794(+) AGAGAC/TGGACA 2 -- ds50010--------
    rs1858268851,2
    C--107761795(+) GAGACA/C/GGACAC 2 -- ds50010--------
    rs1909265491,2
    --107761812(+) CCAGGA/GAAGTA 2 -- ds50010--------
    rs1412187291,2
    --107761856(+) GCCAGA/GACTAG 2 -- ds50010--------
    rs1817305601,2
    --107761867(+) CACCCA/GGGTCT 2 -- ds50010--------
    rs1433789941,2
    --107762110(+) TTGTGA/GTCTGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CD47 (107761941 - 107809935 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD47:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2633277CNV Deletion19546169
    nsv7355OTHER Inversion18451855
    nsv241OTHER Inversion15895083

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601028    OMIM disorders: --

    20/34 diseases for CD47 (see all 34):    About MalaCards
    neonatal meningitis    stem cell leukemia    thrombasthenia    glanzmann's thrombasthenia
    autoimmune hemolytic anemia    malignant pleural mesothelioma    inclusion body myositis    hemolytic anemia
    myositis    meningitis    vaccinia    synovitis
    myeloma    thrombocytopenia    pertussis    anemia
    hyperglycemia    t-cell leukemia    multiple myeloma    acute myeloid leukemia

    2 diseases from the University of Copenhagen DISEASES database for CD47:
    Autoimmune hemolytic anemia     Hemolytic anemia

    CD47 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/18 Novoseek inferred disease relationships for CD47 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glanzmann thrombasthenia 45.5 1 7662966 (1)
    spherocytosis hereditary 43.3 2 12176912 (1), 12393467 (1)
    anemia hemolytic 41.7 3 17163870 (2), 12393467 (1)
    erythroleukemia 25.2 3 11331301 (1), 7691831 (1), 7662966 (1)
    inflammation 24.4 4 17678954 (1), 7732016 (1), 19360900 (1), 19815354 (1)
    necrosis 22.6 7 9653098 (2), 15833768 (1), 7732016 (1), 17253597 (1) (see all 6)
    autoimmune diseases 19.4 2 15359629 (1), 11509584 (1)
    myeloma 13.4 1 15725479 (1)
    hemolysis 11.5 2 12393467 (1), 17163870 (1)
    melanoma 3.92 3 8896608 (1), 12924949 (1), 20161613 (1)

    Genetic Association Database (GAD): CD47

    Export disorders for CD47 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD47 gene, integrated from 9 sources (see all 279):
    (articles sorted by number of sources associating them with CD47)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rh-related antigen CD47 is the signal-transducer integrin-associated protein. (PubMed id 8294396)1, 3, 9 Lindberg F.P....Brown E.J. (1994)
    2. Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. (PubMed id 11454874)1, 2, 9 Rebres R.A.... Brown E.J. (2001)
    3. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47. (PubMed id 18657508)1, 2, 9 Hatherley D....Barclay A.N. (2008)
    4. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane. (PubMed id 10549293)1, 2, 9 Wu A.-L.... Brown E.J. (1999)
    5. Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. (PubMed id 7998989)1, 2, 9 Mawby W.J.... Tanner M.J.A. (1994)
    6. Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in alpha-v beta-3-dependent ligand binding. (PubMed id 7691831)1, 2, 9 Lindberg F.P.... Brown E.J. (1993)
    7. Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down- regulation of IL-12 responsiveness and inhibition of dendritic cell activation. (PubMed id 11509594)1, 2, 9 Latour S.... Sarfati M. (2001)
    8. Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. (PubMed id 15383453)1, 2 Piccio L.... Colonna M. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 961 HGNC: 1682 AceView: CD47 Ensembl:ENSG00000196776 euGenes: HUgn961
    ECgene: CD47 Kegg: 961 H-InvDB: CD47

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD47 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD47 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD47 gene:
    Search GeneIP for patents involving CD47

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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