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Aliases for CD44 Gene

Aliases for CD44 Gene

  • CD44 Molecule (Indian Blood Group) 2 3 5
  • Hematopoietic Cell E- And L-Selectin Ligand 2 3
  • GP90 Lymphocyte Homing/Adhesion Receptor 3 4
  • Chondroitin Sulfate Proteoglycan 8 2 3
  • Extracellular Matrix Receptor III 3 4
  • Heparan Sulfate Proteoglycan 3 4
  • Phagocytic Glycoprotein 1 3 4
  • Hyaluronate Receptor 3 4
  • Hermes Antigen 3 4
  • CD44 Antigen 3 4
  • ECMR-III 3 4
  • HUTCH-I 3 4
  • Epican 3 4
  • CDW44 3 4
  • MDU2 3 4
  • MDU3 3 4
  • MIC4 3 4
  • LHR 3 4
  • CD44 Antigen (Homing Function And Indian Blood Group System) 2
  • Homing Function And Indian Blood Group System 3
  • Cell Surface Glycoprotein CD44 3
  • Phagocytic Glycoprotein I 4
  • Soluble CD44 3
  • CSPG8 3
  • HCELL 3
  • PGP-1 4
  • PGP-I 4
  • MC56 3
  • Pgp1 3
  • IN 3

External Ids for CD44 Gene

Previous HGNC Symbols for CD44 Gene

  • MIC4
  • MDU2
  • MDU3

Previous GeneCards Identifiers for CD44 Gene

  • GC11P036713
  • GC11P035838
  • GC11P035199
  • GC11P035124
  • GC11P035125
  • GC11P035116
  • GC11P034858

Summaries for CD44 Gene

Entrez Gene Summary for CD44 Gene

  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD44 Gene

CD44 (CD44 Molecule (Indian Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include Superficial Keratitis and Lichen Sclerosus. Among its related pathways are Interferon gamma signaling and Cell adhesion_Cell-matrix glycoconjugates. GO annotations related to this gene include transmembrane signaling receptor activity and cytokine receptor activity. An important paralog of this gene is LYVE1.

UniProtKB/Swiss-Prot for CD44 Gene

  • Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

Gene Wiki entry for CD44 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD44 Gene

Genomics for CD44 Gene

Regulatory Elements for CD44 Gene

Enhancers for CD44 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F035081 1.5 FANTOM5 Ensembl ENCODE 35 -53.1 -53068 8.4 PKNOX1 WRNIP1 SIN3A CBX5 FOS ZNF263 JUNB TBX21 ZNF585B PBX2 CD44 LOC100507144 APIP LOC105376627 GC11P035081
GH11F035035 1.5 FANTOM5 Ensembl ENCODE 33.6 -95.4 -95432 16.5 HDGF PKNOX1 WRNIP1 YY1 GATA2 CBX5 FOS JUNB REST TBX21 CD44 NAT10 LOC100507144 APIP GC11M035023 LOC105376626
GH11F035076 1.4 FANTOM5 Ensembl ENCODE 32 -60.3 -60300 4.9 PKNOX1 CBX5 ETV6 FOS CREM SMARCC1 CBFB JUNB NR2F2 IKZF1 CD44 LOC100507144 APIP GC11P035081 LOC105376626
GH11F035157 1.1 FANTOM5 Ensembl ENCODE 28.1 +30.7 30681 24.1 PKNOX1 WRNIP1 YY1 ELK1 CBX5 FOS JUNB PPARG TBX21 KAT8 CD44 LOC100507144 MIR1343 APIP PDHX ENSG00000255004 GC11P035210
GH11F035006 1 FANTOM5 Ensembl ENCODE 24.5 -128.1 -128064 9.8 ATF1 PKNOX1 CREB3L1 FEZF1 CBX5 FOS DEK JUNB NCOA1 TBX21 APIP CD44 PDHX LOC100507144 MIR1343 PAMR1 GC11M035009 GC11P034975
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CD44 on UCSC Golden Path with GeneCards custom track

Promoters for CD44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108566 1630 3801 TBP WRNIP1 KLF17 SIN3A RAD21 GLIS2 ZNF391 SMARCC1 SP3 SMAD5

Genomic Location for CD44 Gene

Chromosome:
11
Start:
35,138,870 bp from pter
End:
35,232,402 bp from pter
Size:
93,533 bases
Orientation:
Plus strand

Genomic View for CD44 Gene

Genes around CD44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD44 Gene

Proteins for CD44 Gene

  • Protein details for CD44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16070-CD44_HUMAN
    Recommended name:
    CD44 antigen
    Protein Accession:
    P16070
    Secondary Accessions:
    • A5YRN9
    • B6EAT9
    • D3DR12
    • D3DR13
    • O95370
    • P22511
    • Q04858
    • Q13419
    • Q13957
    • Q13958
    • Q13959
    • Q13960
    • Q13961
    • Q13967
    • Q13968
    • Q13980
    • Q15861
    • Q16064
    • Q16065
    • Q16066
    • Q16208
    • Q16522
    • Q86T72
    • Q86Z27
    • Q8N694
    • Q92493
    • Q96J24
    • Q9H5A5
    • Q9UC28
    • Q9UC29
    • Q9UC30
    • Q9UCB0
    • Q9UJ36

    Protein attributes for CD44 Gene

    Size:
    742 amino acids
    Molecular mass:
    81538 Da
    Quaternary structure:
    • Interacts with PKN2 (By similarity). Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (PubMed:14992719, PubMed:17085435). Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with UNC119 (PubMed:19381274).

    Three dimensional structures from OCA and Proteopedia for CD44 Gene

neXtProt entry for CD44 Gene

Post-translational modifications for CD44 Gene

  • N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
  • Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
  • Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
  • Glycosylation at Asn 25, Asn 57, Asn 100, Asn 110, Asn 120, Thr 174, Thr 200, Thr 318, Thr 325, Ser 330, Asn 350, Ser 422, Thr 423, Thr 424, Thr 426, Ser 430, Thr 433, Ser 434, Ser 458, Thr 480, Thr 484, Ser 514, Thr 541, Asn 548, Tyr 560, Thr 561, Ser 562, Thr 567, Ser 570, Thr 572, Ser 578, Asn 599, Asn 636, Thr 637, and Thr 638
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD44 (CD44)
  • Abcam antibodies for CD44

No data available for DME Specific Peptides for CD44 Gene

Domains & Families for CD44 Gene

Suggested Antigen Peptide Sequences for CD44 Gene

Graphical View of Domain Structure for InterPro Entry

P16070

UniProtKB/Swiss-Prot:

CD44_HUMAN :
  • The lectin-like LINK domain is responsible for hyaluronan binding.
Domain:
  • The lectin-like LINK domain is responsible for hyaluronan binding.
  • Contains 1 Link domain.
genes like me logo Genes that share domains with CD44: view

Function for CD44 Gene

Molecular function for CD44 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD44 (Pgp-1),80-95kDa,identified by antibodies GRHL1,F10-44-2 (including MDU2,MDU3,MIC4 identified by monoclonal antibodies A1G3,13D8,F10.44),lymphocyte homing receptor,involved in extracellular matrix adhesion and in myeloid differentiation,expressed in small lymphocytic and mantle cell lymphoma,on leukemic blasts from most AML patients,and in invasive basal cell carcinomas
UniProtKB/Swiss-Prot Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

Gene Ontology (GO) - Molecular Function for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 contributes_to cytokine receptor activity IDA 17045821
GO:0005515 protein binding IPI 11207560
GO:0005518 collagen binding NAS 2471973
GO:0005540 hyaluronic acid binding IEA,NAS 1991450
genes like me logo Genes that share ontologies with CD44: view
genes like me logo Genes that share phenotypes with CD44: view

Animal Models for CD44 Gene

MGI Knock Outs for CD44:

Animal Model Products

Clone Products

  • Addgene plasmids for CD44

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD44 Gene

Localization for CD44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD44 Gene

Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. {ECO:0000250 UniProtKB:P15379}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD44 Gene COMPARTMENTS Subcellular localization image for CD44 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
cytoskeleton 3
cytosol 3
endosome 2
lysosome 2
mitochondrion 2
nucleus 2
vacuole 2
chloroplast 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane NAS 1991450
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CD44: view

Pathways & Interactions for CD44 Gene

genes like me logo Genes that share pathways with CD44: view

SIGNOR curated interactions for CD44 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion NAS 1922057
GO:0016337 single organismal cell-cell adhesion NAS 1922057
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with CD44: view

Drugs & Compounds for CD44 Gene

(54) Drugs for CD44 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target 439

(44) Additional Compounds for CD44 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD44: view

Transcripts for CD44 Gene

Unigene Clusters for CD44 Gene

CD44 molecule (Indian blood group):
Representative Sequences:

Clone Products

  • Addgene plasmids for CD44

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD44 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - -
SP10: - - - -
SP11: - - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - -
SP16: - - - -
SP17: - - - -
SP18: - - - -
SP19:
SP20:
SP21:
SP22: -
SP23: - - - - - - - - - -
SP24:
SP25: - - - -
SP26: - - - -
SP27:
SP28:
SP29: - - - - - - - - - - - - - - -
SP30:
SP31: -
SP32:
SP33:

ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - - -
SP16: - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - - - - - - -
SP19: - - - - -
SP20: - - - - - - - - - - - - -
SP21: - -
SP22:
SP23: - - - - - - - - - - - - - - - - - -
SP24:
SP25: - - - - - - - - - - - - - - - - - - - -
SP26: - - - - -
SP27: - - - - - - - - - - - - - - -
SP28:
SP29: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP30: - - -
SP31:
SP32:
SP33:

ExUns: 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b · 26c
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28: -
SP29: - -
SP30:
SP31:
SP32:
SP33: - - - - -

Relevant External Links for CD44 Gene

GeneLoc Exon Structure for
CD44
ECgene alternative splicing isoforms for
CD44

Expression for CD44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD44 Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for CD44 Gene

This gene is overexpressed in Nasal epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD44 Gene



NURSA nuclear receptor signaling pathways regulating expression of CD44 Gene:

CD44

SOURCE GeneReport for Unigene cluster for CD44 Gene:

Hs.502328

mRNA Expression by UniProt/SwissProt for CD44 Gene:

P16070-CD44_HUMAN
Tissue specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
genes like me logo Genes that share expression patterns with CD44: view

Primer Products

No data available for Protein tissue co-expression partners for CD44 Gene

Orthologs for CD44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD44 34 35
  • 99.1 (n)
cow
(Bos Taurus)
Mammalia CD44 34 35
  • 87.69 (n)
dog
(Canis familiaris)
Mammalia CD44 34 35
  • 85.49 (n)
rat
(Rattus norvegicus)
Mammalia Cd44 34
  • 79.94 (n)
mouse
(Mus musculus)
Mammalia Cd44 34 16 35
  • 78.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CD44 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD44 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD44 34 35
  • 66.41 (n)
lizard
(Anolis carolinensis)
Reptilia CD44 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd44 34
  • 52.68 (n)
MGC75816 34
zebrafish
(Danio rerio)
Actinopterygii cd44b 35
  • 22 (a)
OneToMany
cd44a 35
  • 19 (a)
OneToMany
Species where no ortholog for CD44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD44 Gene

ENSEMBL:
Gene Tree for CD44 (if available)
TreeFam:
Gene Tree for CD44 (if available)

Paralogs for CD44 Gene

Paralogs for CD44 Gene

genes like me logo Genes that share paralogs with CD44: view

Variants for CD44 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD44 Gene

CD44_HUMAN-P16070
CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46.

Sequence variations from dbSNP and Humsavar for CD44 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs121909545 Benign 35,176,643(+) TCTCT(C/G)GGACG reference, missense
rs112762 other 35,171,082(+) ATACA(C/T)AATGA intron-variant
rs353612 other 35,158,104(-) AACAA(C/T)GCAAA intron-variant
rs353618 other 35,153,498(-) TCACA(A/G)AATTG intron-variant
rs353623 other 35,150,575(-) TCTGA(C/T)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD44 Gene

Variant ID Type Subtype PubMed ID
esv2744344 CNV deletion 23290073
esv2759818 CNV loss 17122850
esv3424330 CNV insertion 20981092
esv3547587 CNV deletion 23714750
esv3625922 CNV loss 21293372
esv3625923 CNV loss 21293372
esv3625924 CNV loss 21293372
esv3625925 CNV gain 21293372
nsv1042014 CNV loss 25217958
nsv39411 CNV insertion 16902084
nsv508623 CNV deletion 20534489
nsv951602 CNV duplication 24416366

Variation tolerance for CD44 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD44 Gene

Human Gene Mutation Database (HGMD)
CD44
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD44