Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD44 Gene

Aliases for CD44 Gene

  • CD44 Molecule (Indian Blood Group) 2 3 5
  • Hematopoietic Cell E- And L-Selectin Ligand 2 3
  • GP90 Lymphocyte Homing/Adhesion Receptor 3 4
  • Chondroitin Sulfate Proteoglycan 8 2 3
  • Extracellular Matrix Receptor III 3 4
  • Heparan Sulfate Proteoglycan 3 4
  • Phagocytic Glycoprotein 1 3 4
  • Hyaluronate Receptor 3 4
  • Hermes Antigen 3 4
  • ECMR-III 3 4
  • HUTCH-I 3 4
  • Epican 3 4
  • CDW44 3 4
  • MDU2 3 4
  • MDU3 3 4
  • MIC4 3 4
  • LHR 3 4
  • CD44 Antigen (Homing Function And Indian Blood Group System) 2
  • Homing Function And Indian Blood Group System 3
  • Cell Surface Glycoprotein CD44 3
  • Phagocytic Glycoprotein I 4
  • Soluble CD44 3
  • CD44 Antigen 4
  • CSPG8 3
  • HCELL 3
  • PGP-1 4
  • PGP-I 4
  • MC56 3
  • Pgp1 3
  • IN 3

External Ids for CD44 Gene

Previous HGNC Symbols for CD44 Gene

  • MIC4
  • MDU2
  • MDU3

Previous GeneCards Identifiers for CD44 Gene

  • GC11P036713
  • GC11P035838
  • GC11P035199
  • GC11P035124
  • GC11P035125
  • GC11P035116
  • GC11P034858

Summaries for CD44 Gene

Entrez Gene Summary for CD44 Gene

  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD44 Gene

CD44 (CD44 Molecule (Indian Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include superficial keratitis and lichen sclerosus. Among its related pathways are Platelet activation, signaling and aggregation and Degradation of the extracellular matrix. GO annotations related to this gene include transmembrane signaling receptor activity and cytokine receptor activity. An important paralog of this gene is LYVE1.

UniProtKB/Swiss-Prot for CD44 Gene

  • Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

Gene Wiki entry for CD44 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD44 Gene

Genomics for CD44 Gene

Regulatory Elements for CD44 Gene

Genomic Location for CD44 Gene

Chromosome:
11
Start:
35,138,870 bp from pter
End:
35,232,402 bp from pter
Size:
93,533 bases
Orientation:
Plus strand

Genomic View for CD44 Gene

Genes around CD44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD44 Gene

Proteins for CD44 Gene

  • Protein details for CD44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16070-CD44_HUMAN
    Recommended name:
    CD44 antigen
    Protein Accession:
    P16070
    Secondary Accessions:
    • A5YRN9
    • B6EAT9
    • D3DR12
    • D3DR13
    • O95370
    • P22511
    • Q04858
    • Q13419
    • Q13957
    • Q13958
    • Q13959
    • Q13960
    • Q13961
    • Q13967
    • Q13968
    • Q13980
    • Q15861
    • Q16064
    • Q16065
    • Q16066
    • Q16208
    • Q16522
    • Q86T72
    • Q86Z27
    • Q8N694
    • Q92493
    • Q96J24
    • Q9H5A5
    • Q9UC28
    • Q9UC29
    • Q9UC30
    • Q9UCB0
    • Q9UJ36

    Protein attributes for CD44 Gene

    Size:
    742 amino acids
    Molecular mass:
    81538 Da
    Quaternary structure:
    • Interacts with PKN2 (By similarity). Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (PubMed:14992719, PubMed:17085435). Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with UNC119 (PubMed:19381274).

    Three dimensional structures from OCA and Proteopedia for CD44 Gene

neXtProt entry for CD44 Gene

Proteomics data for CD44 Gene at MOPED

Post-translational modifications for CD44 Gene

  • N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
  • Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
  • Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
  • Glycosylation at Asn 25, Asn 57, Asn 100, Asn 110, Asn 120, Thr 174, Thr 200, Thr 318, Thr 325, Ser 330, Asn 350, Ser 422, Thr 423, Thr 424, Thr 426, Ser 430, Thr 433, Ser 434, Ser 458, Thr 480, Thr 484, Ser 514, Thr 541, Asn 548, Tyr 560, Thr 561, Ser 562, Thr 567, Ser 570, Thr 572, Ser 578, Asn 599, Asn 636, Thr 637, and Thr 638
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD44 Gene

Domains & Families for CD44 Gene

Suggested Antigen Peptide Sequences for CD44 Gene

Graphical View of Domain Structure for InterPro Entry

P16070

UniProtKB/Swiss-Prot:

CD44_HUMAN :
  • The lectin-like LINK domain is responsible for hyaluronan binding.
Domain:
  • The lectin-like LINK domain is responsible for hyaluronan binding.
  • Contains 1 Link domain.
genes like me logo Genes that share domains with CD44: view

Function for CD44 Gene

Molecular function for CD44 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD44 (Pgp-1),80-95kDa,identified by antibodies GRHL1,F10-44-2 (including MDU2,MDU3,MIC4 identified by monoclonal antibodies A1G3,13D8,F10.44),lymphocyte homing receptor,involved in extracellular matrix adhesion and in myeloid differentiation,expressed in small lymphocytic and mantle cell lymphoma,on leukemic blasts from most AML patients,and in invasive basal cell carcinomas
UniProtKB/Swiss-Prot Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).
genes like me logo Genes that share phenotypes with CD44: view

Animal Models for CD44 Gene

MGI Knock Outs for CD44:

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD44 Gene

Localization for CD44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD44 Gene

Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. {ECO:0000250 UniProtKB:P15379}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD44 Gene COMPARTMENTS Subcellular localization image for CD44 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
cytoskeleton 3
cytosol 3
endosome 2
lysosome 2
mitochondrion 2
nucleus 2
vacuole 2
chloroplast 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 16809613
genes like me logo Genes that share ontologies with CD44: view

Pathways & Interactions for CD44 Gene

genes like me logo Genes that share pathways with CD44: view

SIGNOR curated interactions for CD44 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion NAS 1922057
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030212 hyaluronan metabolic process TAS --
genes like me logo Genes that share ontologies with CD44: view

Drugs & Compounds for CD44 Gene

(47) Drugs for CD44 Gene - From: Novoseek, DGIdb, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma Target 362

(51) Additional Compounds for CD44 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD44: view

Transcripts for CD44 Gene

Unigene Clusters for CD44 Gene

CD44 molecule (Indian blood group):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD44 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - -
SP10: - - - -
SP11: - - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - -
SP16: - - - -
SP17: - - - -
SP18: - - - -
SP19:
SP20:
SP21:
SP22: -
SP23: - - - - - - - - - -
SP24:
SP25: - - - -
SP26: - - - -
SP27:
SP28:
SP29: - - - - - - - - - - - - - - -
SP30:
SP31: -
SP32:
SP33:

ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - - -
SP16: - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - - - - - - -
SP19: - - - - -
SP20: - - - - - - - - - - - - -
SP21: - -
SP22:
SP23: - - - - - - - - - - - - - - - - - -
SP24:
SP25: - - - - - - - - - - - - - - - - - - - -
SP26: - - - - -
SP27: - - - - - - - - - - - - - - -
SP28:
SP29: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP30: - - -
SP31:
SP32:
SP33:

ExUns: 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b · 26c
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28: -
SP29: - -
SP30:
SP31:
SP32:
SP33: - - - - -

Relevant External Links for CD44 Gene

GeneLoc Exon Structure for
CD44
ECgene alternative splicing isoforms for
CD44

Expression for CD44 Gene

mRNA expression in normal human tissues for CD44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD44 Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for CD44 Gene

This gene is overexpressed in Nasal epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD44 Gene



SOURCE GeneReport for Unigene cluster for CD44 Gene Hs.502328

mRNA Expression by UniProt/SwissProt for CD44 Gene

P16070-CD44_HUMAN
Tissue specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
genes like me logo Genes that share expression patterns with CD44: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CD44 Gene

Orthologs for CD44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD44 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD44 35
  • 87.69 (n)
  • 88.08 (a)
CD44 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD44 35
  • 85.49 (n)
  • 84.57 (a)
CD44 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd44 35
  • 78.71 (n)
  • 70.24 (a)
Cd44 16
Cd44 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD44 35
  • 99.1 (n)
  • 98.52 (a)
CD44 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd44 35
  • 79.94 (n)
  • 71.33 (a)
oppossum
(Monodelphis domestica)
Mammalia CD44 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD44 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD44 35
  • 66.41 (n)
  • 61.24 (a)
CD44 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD44 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd44 35
  • 52.68 (n)
  • 43.75 (a)
MGC75816 35
zebrafish
(Danio rerio)
Actinopterygii cd44a 36
  • 19 (a)
OneToMany
cd44b 36
  • 22 (a)
OneToMany
Species with no ortholog for CD44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD44 Gene

ENSEMBL:
Gene Tree for CD44 (if available)
TreeFam:
Gene Tree for CD44 (if available)

Paralogs for CD44 Gene

Paralogs for CD44 Gene

genes like me logo Genes that share paralogs with CD44: view

Variants for CD44 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD44 Gene

P16070-CD44_HUMAN
CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46.

Sequence variations from dbSNP and Humsavar for CD44 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_006490 -
rs9666607 - 35,204,608(+) ACCCA(A/G)AGAAG intron-variant, reference, missense
rs11607491 - 35,204,536(+) TACAA(C/T)GGAAG intron-variant, reference, missense
rs1467558 - 35,208,126(-) GCGTT(A/G)TACTA intron-variant, reference, missense
rs12273397 - 35,208,170(+) TGGAA(C/G/T)ATTTG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD44 Gene

Variant ID Type Subtype PubMed ID
dgv361e1 CNV Complex 17122850
nsv508623 CNV Loss 20534489
esv2744344 CNV Deletion 23290073
nsv39411 CNV Insertion 16902084
dgv1071n71 CNV Gain 21882294
dgv1072n71 CNV Gain 21882294

Variation tolerance for CD44 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD44 Gene

HapMap Linkage Disequilibrium report
CD44
Human Gene Mutation Database (HGMD)
CD44
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

Disorders for CD44 Gene

MalaCards: The human disease database

(51) MalaCards diseases for CD44 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
superficial keratitis
lichen sclerosus
  • lichen sclerosis
intraductal papilloma
  • ductal papilloma
tongue squamous cell carcinoma
  • squamous-cell carcinoma
hodgkin's lymphoma, lymphocytic-histiocytic predominance
  • hodgkin lymphoma, lymphocyte-rich
- elite association - COSMIC cancer census association via MalaCards
Search CD44 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD44

Genetic Association Database (GAD)
CD44
Human Genome Epidemiology (HuGE) Navigator
CD44
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD44
genes like me logo Genes that share disorders with CD44: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD44 Gene

Publications for CD44 Gene

  1. Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase. (PMID: 8352881) Tanabe K.K. … Saya H. (Mol. Carcinog. 1993) 3 4 23 67
  2. CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification. (PMID: 19350388) Klingbeil P. … Isacke C.M. (Breast Cancer Res. Treat. 2010) 3 23
  3. Coexpression of CD44 variant isoforms and receptor for hyaluronic acid-mediated motility (RHAMM, CD168) is an International Prognostic Index and C-MYC gene status-independent predictor of poor outcome in diffuse large B-cell lymphomas. (PMID: 19857547) Nagel S. … Tzankov A. (Exp. Hematol. 2010) 3 23
  4. Induction of CD44 cleavage in articular chondrocytes. (PMID: 20178130) Takahashi N. … Knudson W. (Arthritis Rheum. 2010) 3 23
  5. Immuno-localization of CD44 and osteopontin in developing human kidney. (PMID: 18787423) Crisi G.M. … Campfield T.J. (Pediatr. Res. 2009) 3 23

Products for CD44 Gene

Sources for CD44 Gene

Back to Top

Content