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CD44 Gene

protein-coding   GIFtS: 71
GCID: GC11P035168

CD44 Molecule (Indian Blood Group)

(Previous name: CD44 antigen (homing function and Indian blood group system))
(Previous symbols: MIC4, MDU2, MDU3)
  See CD44-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD44 Molecule (Indian Blood Group)1 2     IN2 5
MDU21 2 3 5     CD44 Antigen (Homing Function And Indian Blood Group System)1
MDU31 2 3 5     CDW442
MIC41 2 3 5     CSPG82
Chondroitin Sulfate Proteoglycan 81 2     HCELL2
Hematopoietic Cell E- And L-Selectin Ligand1 2     MC562
Extracellular Matrix Receptor III2 3     Pgp12
Heparan Sulfate Proteoglycan2 3     Cell Surface Glycoprotein CD442
Hyaluronate Receptor2 3     epican2
Phagocytic Glycoprotein 12 3     Homing Function And Indian Blood Group System2
ECMR-III2 3     CDw443
HUTCH-I2 3     Epican3
LHR2 3     PGP-13
CD44 Antigen2 3     PGP-I3
GP90 Lymphocyte Homing/Adhesion Receptor2 3     Phagocytic Glycoprotein I3
Hermes Antigen2 3     

External Ids:    HGNC: 16811   Entrez Gene: 9602   Ensembl: ENSG000000265087   OMIM: 1072695   UniProtKB: P160703   

Export aliases for CD44 gene to outside databases

Previous GC identifers: GC11P036713 GC11P035838 GC11P035199 GC11P035124 GC11P035125 GC11P035116 GC11P034858


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD44 Gene:
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion
and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as
osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of
cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor
metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally
distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative
splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor
metastasis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD44 Gene:
CD44 (CD44 molecule (Indian blood group)) is a protein-coding gene. Diseases associated with CD44 include superficial keratitis, and gastrointestinal lymphoma. GO annotations related to this gene include transmembrane signaling receptor activity and hyaluronic acid binding. An important paralog of this gene is LYVE1.

UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity
for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix
metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and
progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte
activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous
pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational
modification events

Gene Wiki entry for CD44 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD44 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD44 promoter sequence
   Search Chromatin IP Primers for CD44

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

CD44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD44 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P035168:  view genomic region     (about GC identifiers)

Start:
35,160,417 bp from pter      End:
35,253,949 bp from pter
Size:
93,533 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CD44_HUMAN, P16070 (See protein sequence)
Recommended Name: CD44 antigen precursor  
Size: 742 amino acids; 81538 Da
Subunit: Interacts with PKN2. Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other
glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM
proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment
3 PDB 3D structures from and Proteopedia for CD44:
1POZ (3D)        1UUH (3D)        2I83 (3D)    
Secondary accessions: A5YRN9 B6EAT9 D3DR12 D3DR13 O95370 P22511 Q04858 Q13419 Q13957 Q13958
Q13959 Q13960 Q13961 Q13967 Q13968 Q13980 Q15861 Q16064 Q16065 Q16066 Q16208 Q16522 Q86T72
Q86Z27 Q8N694 Q92493 Q96J24 Q9H5A5 Q9UC28 Q9UC29 Q9UC30 Q9UCB0 Q9UJ36
Alternative splicing: 19 isoforms:  P16070-1   P16070-2   P16070-3   P16070-4   P16070-5   P16070-6   P16070-7   P16070-8   
P16070-9   P16070-10   P16070-11   P16070-12   P16070-13   P16070-14   P16070-15   P16070-16   
P16070-17   P16070-18   P16070-19   (Soluble isoform, has enhanced hyaluronan binding)

Explore the universe of human proteins at neXtProt for CD44: NX_P16070

Explore proteomics data for CD44 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines
    and tumors1
  • N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number
    may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if
    O-glycosylation occurs on Thr-637 or Thr-6381
  • Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site),
    and the phosphorylation of Ser-6721
  • Glycosylation2 at Asn25, Asn57, Asn100, Asn110, Asn120, Thr174, Thr197, Ser199, Thr200, Thr318,
                                 Thr325, Ser330, Ser332, Asn350, Tyr412, Ser422, Thr423, Thr424, Thr426, Ser430 (see all 51)
  • Modification sites at PhosphoSitePlus

  • See CD44 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_000601.3  NP_001001389.1  NP_001001390.1  NP_001001391.1  NP_001001392.1  NP_001189484.1  NP_001189485.1  NP_001189486.1  

    ENSEMBL proteins: 
     ENSP00000263398   ENSP00000435377   ENSP00000389830   ENSP00000398632   ENSP00000432704  
     ENSP00000395953   ENSP00000392331   ENSP00000278386   ENSP00000404447   ENSP00000309732  
     ENSP00000398099   ENSP00000432405   ENSP00000434465   ENSP00000279452   ENSP00000434530  
     ENSP00000432718   ENSP00000433189   ENSP00000436549   ENSP00000436623   ENSP00000436980  
     ENSP00000278385   ENSP00000435321   ENSP00000436451   ENSP00000434418   ENSP00000431860  
     ENSP00000434920   ENSP00000414567   ENSP00000391008   ENSP00000403990   ENSP00000353280  
    Reactome Protein details: P16070

    CD44 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD44
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CD44
    OriGene Protein Over-expression Lysate for CD44
    OriGene MassSpec for CD44
    OriGene Custom Protein Services for CD44
    GenScript Custom Purified and Recombinant Proteins Services for CD44
    Novus Biologicals CD44 Proteins
    Novus Biologicals CD44 Lysates
    Sino Biological Recombinant Protein for CD44
    Sino Biological Cell Lysate for CD44
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    eBioscience Proteins for CD44:  
                        Recombinant Human CD44 Std 100 ug

     
    antibodies-online proteins for CD44 (21 products) 

     
    antibodies-online peptides for CD44

    CD44 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD44
    R&D Systems Antibodies for CD44
    Cell Signaling Technology (CST) Antibodies for CD44 
    OriGene Antibodies for CD44
    OriGene Custom Antibody Services for CD44
    Novus Biologicals CD44 Antibodies
    Abcam antibodies for CD44 (P16070, O95370, P07766)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CD44
    LSBio Antibodies in human, mouse, rat for CD44
    antibodies-online antibodies for CD44 (870 products) 

    CD44 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD44
    R&D Systems ELISAs for CD44         (see all)
    GenScript Custom Assay Services for CD44
    Enzo Life Sciences assays for CD44
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    eBioscience ELISAs for CD44: (see all 8
                        Human sCD44std Platinum ELISA 96 tests
    antibodies-online kits for CD44 (22 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CSPG: Proteoglycans / Cell surface : Other
    CD: CD molecules
    bloodgroup: Blood group antigens

    4 InterPro protein domains:
     IPR000538 Link
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001231 CD44_antigen

    Graphical View of Domain Structure for InterPro Entry P16070

    ProtoNet protein and cluster: P16070

    2 Blocks protein domains:
    IPB000538 Link domain
    IPB001231 CD44 antigen precursor signature


    UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
    Domain: The lectin-like LINK domain is responsible for hyaluronan binding (By similarity)
    Similarity: Contains 1 Link domain


    Find genes that share domains with CD44           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD44_HUMAN, P16070
    Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity
    for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix
    metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and
    progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte
    activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous
    pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational
    modification events

         Genatlas biochemistry entry for CD44:
    cell differentiation antigen CD44 (Pgp-1),80-95kDa,identified by antibodies GRHL1,F10-44-2 (including
    MDU2,MDU3,MIC4 identified by monoclonal antibodies A1G3,13D8,F10.44),lymphocyte homing receptor,involved in
    extracellular matrix adhesion and in myeloid differentiation,expressed in small lymphocytic and mantle cell
    lymphoma,on leukemic blasts from most AML patients,and in invasive basal cell carcinomas

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004415hyalurononglucosaminidase activity IDA17170110
    GO:0004888contributes to transmembrane signaling receptor activity IDA17045821
    GO:0005515protein binding IPI11207560
    GO:0005518collagen binding NAS2471973
    GO:0005540hyaluronic acid binding NAS1991450
         
    Find genes that share ontologies with CD44           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CD44:
     Decreased focal adhesion (FA)  

         Selected MGI mutant phenotypes (inferred from 9 alleles(MGI details for Cd44) (see all 22):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with CD44           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD44: Cd44tm2.1Ugu Cd44tm1.1Ugu Cd44tm2Kmz Cd44tm1Mak Cd44tm1Ugu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD44
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD44

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD44
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD44

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD44:
    hsa-mir-320a (MIRT044488), hsa-mir-608 (MIRT005967), hsa-mir-199a-3p (MIRT003790), hsa-mir-520c-3p (MIRT004082), hsa-mir-744-5p (MIRT037402), hsa-mir-216a-5p (MIRT005969), hsa-mir-708-5p (MIRT006474), hsa-mir-30a-5p (MIRT028389), hsa-mir-1 (MIRT023486), hsa-mir-373-3p (MIRT002428), hsa-mir-34a-5p (MIRT005480), hsa-mir-15b-5p (MIRT046387), hsa-mir-16-5p (MIRT031409), hsa-mir-328-3p (MIRT000989), hsa-mir-330-3p (MIRT005968)

    Block miRNA regulation of human, mouse, rat CD44 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD44 (see all 62):
    hsa-miR-579 hsa-miR-3164 hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-3146
    SwitchGear 3'UTR luciferase reporter plasmidCD44 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD44
    Predesigned siRNA for gene silencing in human, mouse, rat CD44

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD44

    Clone
    Products:
         
    OriGene clones in human, mouse for CD44 (see all 32)
    OriGene ORF clones in mouse, rat for CD44
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): CD44 (NM_001202555)
    Sino Biological Human cDNA Clone for CD44
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD44
    Addgene plasmids for CD44 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD44
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD44 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD44

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10360) for CD44 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD44_HUMAN, P16070: Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane
    protrusions at wounding edges (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus4
    cytoskeleton3
    extracellular3
    nucleus2
    endoplasmic reticulum1
    endosome1
    mitochondrion1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS1991450
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with CD44           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD44 About   (see all 28)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    3Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    Glioma Invasiveness0.64
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    5Paxillin-dependent events mediated by a4b1
    Paxillin-independent events mediated by a4b1 and a4b70.58


    Find genes that share SuperPaths with CD44           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CD44
        Articular Cartilage Extracellular Matrix
    VEGF - VEGF R2 Signaling Pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD44
        Rac1 Pathway
    Glioma Invasiveness

    2 Cell Signaling Technology (CST) Pathways for CD44
        Lymphocyte Signaling
    Adhesion

    4 GeneGo (Thomson Reuters) Pathways for CD44
        Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion ECM remodeling
    Development Beta-adrenergic receptors regulation of ERK
    Signal transduction Calcium signaling

    5 BioSystems Pathways for CD44
        Senescence and Autophagy
    Wnt Signaling Pathway and Pluripotency
    TGF-beta Receptor Signaling Pathway
    Osteopontin-mediated events
    Paxillin-independent events mediated by a4b1 and a4b7


    5 Reactome Pathways for CD44
        Integrin cell surface interactions
    Interferon gamma signaling
    Hyaluronan uptake and degradation
    Degradation of the extracellular matrix
    Cell surface interactions at the vascular wall


    Selected Kegg Pathways  (Kegg details for CD44) (see all 6):
        ECM-receptor interaction
    Hematopoietic cell lineage
    Shigellosis
    Epstein-Barr virus infection
    Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD44 (see all 17): 
              Parkinson's Disease in human mouse rat
              HIV Host Response in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Multiple Sclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD44

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD44 (P160701, 3 ENSP000002783854) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC7A11Q9UPY51, 3, ENSP000002806124EBI-490245,EBI-3843348 I2D: score=1 STRING: ENSP00000280612
    HBEGFQ990753, ENSP000002309904I2D: score=3 STRING: ENSP00000230990
    LCKP062393, ENSP000003378254I2D: score=3 STRING: ENSP00000337825
    MMP7P092373, ENSP000002602274I2D: score=3 STRING: ENSP00000260227
    NF2P352403, ENSP000003446664I2D: score=3 STRING: ENSP00000344666
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0002246wound healing involved in inflammatory response IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007155cell adhesion ----
    GO:0007160cell-matrix adhesion NAS1922057

    Find genes that share ontologies with CD44           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD44

    1 HMDB Compound for CD44    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronic acidhyaluronic acid 9004-61-9--

    1 DrugBank Compound for CD44    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HyaluronanHyaluronate (see all 4)9067-32-7target----

    Selected Novoseek inferred chemical compound relationships for CD44 gene (see all 98)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 84 381 15828943 (7), 17076095 (7), 11721159 (6), 9634638 (5) (see all 99)
    glycosaminoglycan 70.9 35 9298694 (3), 7504022 (1), 7515731 (1), 9058710 (1) (see all 28)
    chondroitin sulfate 59.1 66 10950950 (6), 9891023 (4), 8546427 (2), 8752662 (2) (see all 25)
    matrigel 52.9 11 1906507 (2), 19724912 (2), 7518347 (2), 9815853 (1) (see all 7)
    heparan sulfate 47.5 46 7532176 (7), 9891023 (4), 10950950 (2), 10583162 (2) (see all 16)
    paraffin 46.1 19 15867228 (1), 9666819 (1), 9833394 (1), 10550296 (1) (see all 18)
    slex 35.4 7 9430509 (2), 8547121 (1), 19651422 (1), 8838015 (1)
    vegf 29.5 45 19638429 (5), 20073217 (3), 9893599 (3), 19017033 (2) (see all 25)
    chondroitin 29.3 10 10950950 (3), 9334256 (1), 11821431 (1), 10222064 (1) (see all 6)
    tunicamycin 28.7 3 8601595 (1), 10714394 (1), 9111868 (1)



    Find genes that share compounds with CD44           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for CD44 gene (8 alternative transcripts): 
    NM_000610.3  NM_001001389.1  NM_001001390.1  NM_001001391.1  NM_001001392.1  NM_001202555.1  NM_001202556.1  NM_001202557.1  

    Unigene Cluster for CD44:

    CD44 molecule (Indian blood group)
    Hs.502328  [show with all ESTs]
    Unigene Representative Sequence: NM_000610
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 42):
    ENST00000263398(uc001mvu.3 uc001mvv.3 uc001mvw.3 uc001mwc.4 uc001mvx.3 uc010rer.2 uc001mvy.3 uc009ykh.3)
    ENST00000526025 ENST00000415148 ENST00000528086 ENST00000428726 ENST00000526669
    ENST00000425428 ENST00000433892(uc010ret.2) ENST00000278386 ENST00000434472
    ENST00000352818 ENST00000442151(uc021qfw.1) ENST00000525211 ENST00000526000
    ENST00000279452 ENST00000527889 ENST00000531118 ENST00000528455
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CD44 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD44 (see all 62):
    hsa-miR-579 hsa-miR-3164 hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-3146
    SwitchGear 3'UTR luciferase reporter plasmidCD44 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CD44
    Predesigned siRNA for gene silencing in human, mouse, rat CD44
    Clone
    Products:
         
    OriGene clones in human, mouse for CD44 (see all 32)
    OriGene ORF clones in mouse, rat for CD44
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): CD44 (NM_001202555)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD44
    Addgene plasmids for CD44 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD44
    OriGene qSTAR qPCR primer pairs in human, mouse for CD44
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD44
      QuantiTect SYBR Green Assays in human, mouse, rat CD44
      QuantiFast Probe-based Assays in human, mouse, rat CD44
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10360) for CD44 

    Additional mRNA sequence: 

    AB073901.1 AF098641.1 AJ251595.1 AK127622.1 AK129808.1 AK290424.1 AK297776.1 AK304467.1 
    AK307707.1 AL832642.2 AY101192.1 AY101193.1 BC004372.1 BC052287.1 BC067348.1 D28447.1 
    EF581837.1 FJ216964.1 M24915.1 M25078.1 M59040.1 M83324.1 M83325.1 M83326.1 
    M83327.1 M83328.1 S66400.1 S82326.1 U40373.1 U94902.1 U94903.1 X55150.1 
    X55938.1 X56794.1 X62739.1 X66733.1 

    Selected DOTS entries (see all 48):

    DT.100684183  DT.97864832  DT.91789386  DT.95300618  DT.95300704  DT.100684179  DT.92461255  DT.100684175 
    DT.100684181  DT.87016134  DT.450200  DT.95300655  DT.100735366  DT.120740562  DT.120740539  DT.100664096 
    DT.100684170  DT.75143398  DT.40113924  DT.40129290  DT.86843055  DT.95300681  DT.120740557  DT.75100374 

    Selected AceView cDNA sequences (see all 1216):

    AI632506 BQ030406 C01945 BP354214 CK430568 BM760443 AI089856 AJ712599 
    BP346279 AA665779 AI082314 BQ019035 AI368364 BQ212256 AA335788 BQ332271 
    CB306280 BU628803 BQ962000 CR623874 CB138883 AW517914 AI369195 BU527984 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD44 (see all 33)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
    SP1:                                                                                                                                      -           -     -   
    SP2:                                                                                                                                      -     -     -     -   
    SP3:                                                                                                                                      -     -     -     -   
    SP4:                                                                                                                                      -     -     -     -   
    SP5:                                                                                                                                      -     -     -     -   

    ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
    SP1:  -           -     -           -                                         -     -     -                                                     -               
    SP2:  -           -     -           -                                         -     -     -                                                     -               
    SP3:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                         -               
    SP4:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -               
    SP5:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -               

    ExUns: 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b · 26c
    SP1:                                -                     
    SP2:                                -                     
    SP3:                                -                     
    SP4:                                -                     
    SP5:                                                      


    ECgene alternative splicing isoforms for CD44

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD44 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATTGGGG
    CD44 Expression
    About this image


    CD44 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 44) fully expand
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Bone Marrow
             Decidua-derived mesenchymal stem cells
             Mesenchymal stem cells
     
     Bone (Muscoskeletal System)    fully expand to see all 27 entries
             Bone Marrow Stromal Cells Bone Marrow
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells (HYNR-CS inj)
             Chondrocyte-like cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 12 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Adipose-derived stromal cells
     
     Tooth (Integumentary System)    fully expand to see all 12 entries
             Dental Pulp Stem Cells Dental Pulp
             Dental pulp stem cells (family)
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 8 entries
             Mesenchymal Stem Cells Wharton's Jelly
             Umbilical tissue-derived cells (CNTO2476)
    CD44 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD44 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502328

    UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
    Tissue specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by
    carcinomas. Expression is repressed in neuroblastoma cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD44 (see all 17): 
              Parkinson's Disease in human mouse rat
              HIV Host Response in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Multiple Sclerosis in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CD44
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD44

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CD44 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd441 , 5 CD44 antigen1, 5 78.71(n)1
    70.24(a)1
      2 (54.13 cM)5
    125051  NM_009851.21  NP_033981.21 
     1028111415 
    chicken
    (Gallus gallus)
    Aves CD441 CD44 molecule (Indian blood group) 66.41(n)
    61.24(a)
      395666  NM_204860.2  NP_990191.2 
    lizard
    (Anolis carolinensis)
    Reptilia CD446
    CD44 molecule (Indian blood group)
    40(a)
    1 ↔ 1
    1(54803137-54854221)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD361163.12   -- 70.78(n)    CD361163.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cd44b6
    cd44a6
    CD44 molecule (Indian blood group) a
    22(a)
    19(a)
    many → 1
    many → 1
    25(38415471-38430243) ENSDARG00000089892
    7(51339738-51349979) ENSDARG00000087863


    ENSEMBL Gene Tree for CD44 (if available)
    TreeFam Gene Tree for CD44 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD44 gene
    LYVE12  

    Find genes that share paralogs with CD44           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CD44_HUMAN, P16070: CD44 is responsible for the Indian blood group system. The molecular basis of the
    In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele,
    has Arg-46


    Selected SNPs for CD44 (see all 3411)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219095451,2
    Cnon-pathogenic135126765(+) TCTCTC/GGGACG 16 R G mis10--------
    rs792508951,2
    C--34897203(+) AAAAAA/TTTTTT 8 -- int10--------
    rs2003413311,2
    --34901810(+) AAATT-/TATATAT 8 -- int10--------
    rs1905323541,2
    --34901927(+) ATATAA/TTATAT 8 -- int10--------
    rs106757821,2
    C--34901947(+) tatat-/A/AT  
            
    tatat
    8 -- int10--------
    rs30474781,2
    C--34905592(-) GGAGGGAGG/-  
            
    AAGAC
    8 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs349104821,2
    C--34905605(+) CCCTC-/CCC   
      T
    /CCTC
    TCTCC
    8 -- int10--------
    rs30474761,2
    C--34906539(-) TAAGA-/TAGACAC 8 -- int10--------
    rs114484301,2
    C--34918993(+) AAAAA-/AAAAAA 8 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs1395206791,2
    --35090236(+) TCAACA/TGTAAG 8 -- int10--------

    HapMap Linkage Disequilibrium report for CD44 (35160417 - 35253949 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CD44:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744344CNV Deletion23290073
    nsv39411CNV Insertion16902084
    nsv508623CNV Loss20534489
    dgv1072n71CNV Gain21882294
    dgv1071n71CNV Gain21882294
    dgv361e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CD44
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing CD44:
    Oncogenes & Tumor Suppressor Genes 384HC
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing CD44
    DNA2.0 Custom Variant and Variant Library Synthesis for CD44

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107269   
    OMIM disorders: 609027  
    16 diseases for CD44:    
    About MalaCards
    superficial keratitis    gastrointestinal lymphoma    follicular mucinosis    lichen sclerosus
    spinal cord astrocytoma    primary cutaneous anaplastic large cell lymphoma    intraductal papilloma    nonpapillary renal cell carcinoma
    thymic epithelial neoplasm    pleomorphic adenoma    gastrointestinal neuroendocrine tumor    female breast carcinoma
    vulvar intraepithelial neoplasia    gliomatosis cerebri    cardia cancer    myeloma

    14 diseases from the University of Copenhagen DISEASES database for CD44:
    Carcinoma     Breast cancer     Colorectal cancer     Leukemia
    Lymphoma     Prostate cancer     Arthritis     Pancreatic cancer
    Melanoma     Ovarian cancer     Lung cancer     Hypersensitivity reaction type II disease
    Malignant glioma     Kidney disease

    Find genes that share disorders with CD44           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD44 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 78.3 546 11005492 (8), 9772282 (5), 11582589 (5), 17912438 (4) (see all 99)
    tumors 73.6 1071 17912438 (8), 10200702 (8), 8579108 (7), 11839564 (7) (see all 99)
    carcinoma 64.7 229 8567994 (5), 12534600 (4), 9826464 (4), 10547541 (3) (see all 99)
    cancer 61.5 294 11832714 (6), 11313172 (4), 9090502 (3), 7518345 (3) (see all 99)
    primary tumor 57.2 38 14666731 (3), 8682582 (2), 17006832 (2), 12854146 (2) (see all 26)
    colon carcinoma 54.2 55 18234849 (4), 8678563 (4), 11431370 (3), 8858111 (3) (see all 29)
    colorectal carcinoma 53.2 64 12782013 (4), 7504563 (3), 9754757 (3), 11911305 (3) (see all 33)
    adenocarcinoma 52.7 98 7537174 (5), 8599448 (4), 15717748 (4), 8608952 (3) (see all 61)
    aggressiveness 52.1 31 7576964 (3), 10846530 (3), 10355528 (2), 11213839 (1) (see all 20)
    carcinoma squamous cell 50.2 72 17679465 (4), 19900133 (3), 9725567 (3), 8599448 (2) (see all 45)

    Genetic Association Database (GAD): CD44
    Human Genome Epidemiology (HuGE) Navigator: CD44 (24 documents)

    Export disorders for CD44 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD44 gene, integrated from 10 sources (see all 2216):
    (articles sorted by number of sources associating them with CD44)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase. (PubMed id 8352881)1, 2, 9 Tanabe K.K.... Saya H. (Mol. Carcinog. 1993)
    2. Expression of CD44 is repressed in neuroblastoma cells. (PubMed id 1922057)1, 2, 9 Shtivelman E. and Bishop J.M. (Mol. Cell. Biol. 1991)
    3. Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44. (PubMed id 10933060)1, 2, 9 Chiu R.K.... Dougherty G.J. (Neoplasia 1999)
    4. Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325. (PubMed id 9580567)1, 2, 9 Peck D. and Isacke C.M. (J. Cell Sci. 1998)
    5. CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. (PubMed id 1717145)1, 2, 9 Hofmann M....Guenthert U. (Cancer Res. 1991)
    6. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. (PubMed id 20098615)1, 4 Wooten E.C....Huggins G.S. (PLoS ONE 2010)
    7. Unique SNP in CD44 intron 1 and its role in breast cancer development. (PubMed id 20530438)1, 4 Zhou J....Nagarkatti M. (Anticancer Res. 2010)
    8. Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis. (PubMed id 20806065)1, 4 Ryckman K.K....Hennig B.J. (PLoS ONE 2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 960 HGNC: 1681 AceView: CD44 Ensembl:ENSG00000026508 euGenes: HUgn960
    ECgene: CD44 Kegg: 960 H-InvDB: CD44

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD44 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD44 Genetics and Cytogenetics in Oncology and Haematology
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=indian
    Wikipedia http://en.wikipedia.org/wiki/CD44

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD44 gene:
    Search GeneIP for patents involving CD44

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
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     Recombinant/Natural Proteins for CD44 (CD44)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for CD44 (CD44)  
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     Block miRNA regulation of human, mouse, rat CD44 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CD44
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD44 Predesigned siRNA for gene silencing in human, mouse, rat CD44
     QuantiFast Probe-based Assays in human, mouse, rat CD44 QuantiTect SYBR Green Assays in human, mouse, rat CD44
     PCR Arrays including human, mouse, rat CD44 Search Chromatin IP Primers for CD44
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD44  GeneGlobe Interaction Network for CD44
     Regulatory tfbs in CD44 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CD44 GenScript cDNA clones with any tag delivered in your preferred vector for CD44
     GenScript Custom Assay Services for CD44 GenScript Custom overexpressing Cell Line Services for CD44
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for CD44 

     Search Tocris compounds for CD44
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     Search Sino Biological for antibodies, proteins & pathways
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for CD44
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
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     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CD44
     Gene Synthesis
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     SwitchGear 3'UTR luciferase reporter plasmids for CD44
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD44
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD44
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD44
     LSBio Antibodies in human, mouse, rat for CD44
     Browse compounds at ApexBio
     Addgene plasmids for CD44
     eBioscience proteins for CD44 (Recombinant Human CD44 Std 100 ug)
     eBioscience elisas for CD44 (Human sCD44std Platinum ELISA 96 tests)
      eBioscience FlowRNA Probe Sets
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     Humanization
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     antibodies-online peptides for CD44
     antibodies-online proteins for CD44 (21 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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