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Aliases for CD44 Gene

Aliases for CD44 Gene

  • CD44 Molecule (Indian Blood Group) 2 3 5
  • Hematopoietic Cell E- And L-Selectin Ligand 2 3
  • GP90 Lymphocyte Homing/Adhesion Receptor 3 4
  • Chondroitin Sulfate Proteoglycan 8 2 3
  • Extracellular Matrix Receptor III 3 4
  • Heparan Sulfate Proteoglycan 3 4
  • Phagocytic Glycoprotein 1 3 4
  • Hyaluronate Receptor 3 4
  • Hermes Antigen 3 4
  • CD44 Antigen 3 4
  • ECMR-III 3 4
  • HUTCH-I 3 4
  • Epican 3 4
  • CDW44 3 4
  • MDU2 3 4
  • MDU3 3 4
  • MIC4 3 4
  • LHR 3 4
  • CD44 Antigen (Homing Function And Indian Blood Group System) 2
  • Homing Function And Indian Blood Group System 3
  • Cell Surface Glycoprotein CD44 3
  • Phagocytic Glycoprotein I 4
  • Soluble CD44 3
  • CSPG8 3
  • HCELL 3
  • PGP-1 4
  • PGP-I 4
  • MC56 3
  • Pgp1 3
  • IN 3

External Ids for CD44 Gene

Previous HGNC Symbols for CD44 Gene

  • MIC4
  • MDU2
  • MDU3

Previous GeneCards Identifiers for CD44 Gene

  • GC11P036713
  • GC11P035838
  • GC11P035199
  • GC11P035124
  • GC11P035125
  • GC11P035116
  • GC11P034858

Summaries for CD44 Gene

Entrez Gene Summary for CD44 Gene

  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

CIViC summary for CD44 Gene

GeneCards Summary for CD44 Gene

CD44 (CD44 Molecule (Indian Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include Superficial Keratitis and Lichen Sclerosus. Among its related pathways are Hematopoietic cell lineage and Cell adhesion_Cell-matrix glycoconjugates. GO annotations related to this gene include transmembrane signaling receptor activity and cytokine receptor activity. An important paralog of this gene is LYVE1.

UniProtKB/Swiss-Prot for CD44 Gene

  • Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

Gene Wiki entry for CD44 Gene

Additional gene information for CD44 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD44 Gene

Genomics for CD44 Gene

Regulatory Elements for CD44 Gene

Enhancers for CD44 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H035081 1.9 FANTOM5 Ensembl ENCODE dbSUPER 35 -53.3 -53305 7 PKNOX1 SIN3A ZNF143 FOS ATF7 RUNX3 MAFF PBX2 STAT3 NBN CD44 LOC100507144 APIP LOC105376627 GC11P035081
GH11H035042 1.8 FANTOM5 Ensembl ENCODE dbSUPER 33 -92.9 -92939 6 SOX13 PKNOX1 FOXA2 HINFP MAX CEBPG ZBTB40 ZNF644 FOSL1 GATA3 CD44 LOC100507144 APIP GC11M035023 LOC105376626
GH11H035076 1.8 FANTOM5 Ensembl ENCODE dbSUPER 32.1 -60.6 -60578 4 PKNOX1 JUN MAX EBF1 BATF RELA FOSL1 POLR2A EED SMC3 CD44 LOC100507144 APIP GC11P035081 LOC105376626
GH11H035157 1.9 FANTOM5 Ensembl ENCODE dbSUPER 28.1 +27.9 27886 18 PKNOX1 FOXA2 YY1 ATF7 FOS RUNX3 REST PPARG ETV4 STAT3 CD44 LOC100507144 MIR1343 PDHX APIP ENSG00000255004 GC11P035210
GH11H035006 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.6 -128.1 -128064 9 TBP PKNOX1 TBL1XR1 BMI1 FEZF1 BATF RAD21 RFX5 SCRT2 ZNF207 APIP CD44 PDHX LOC100507144 MIR1343 PAMR1 GC11M035009 GC11P034975
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD44 on UCSC Golden Path with GeneCards custom track

Promoters for CD44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000038803 1530 3201 TBP KLF17 SIN3A RAD21 GLIS2 ETV6 ZNF391 RUNX3 SP3 SMARCC1

Genomic Location for CD44 Gene

Chromosome:
11
Start:
35,138,870 bp from pter
End:
35,232,402 bp from pter
Size:
93,533 bases
Orientation:
Plus strand

Genomic View for CD44 Gene

Genes around CD44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD44 Gene

Proteins for CD44 Gene

  • Protein details for CD44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16070-CD44_HUMAN
    Recommended name:
    CD44 antigen
    Protein Accession:
    P16070
    Secondary Accessions:
    • A5YRN9
    • B6EAT9
    • D3DR12
    • D3DR13
    • O95370
    • P22511
    • Q04858
    • Q13419
    • Q13957
    • Q13958
    • Q13959
    • Q13960
    • Q13961
    • Q13967
    • Q13968
    • Q13980
    • Q15861
    • Q16064
    • Q16065
    • Q16066
    • Q16208
    • Q16522
    • Q86T72
    • Q86Z27
    • Q8N694
    • Q92493
    • Q96J24
    • Q9H5A5
    • Q9UC28
    • Q9UC29
    • Q9UC30
    • Q9UCB0
    • Q9UJ36

    Protein attributes for CD44 Gene

    Size:
    742 amino acids
    Molecular mass:
    81538 Da
    Quaternary structure:
    • Interacts with PKN2 (By similarity). Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment (PubMed:14992719, PubMed:17085435). Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with UNC119 (PubMed:19381274).

    Three dimensional structures from OCA and Proteopedia for CD44 Gene

neXtProt entry for CD44 Gene

Post-translational modifications for CD44 Gene

  • N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
  • Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
  • Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
  • Glycosylation at Asn25, Asn57, posLast=100100, posLast=110110, posLast=120120, posLast=174174, Thr200, Thr318, posLast=325325, Ser330, posLast=350350, Ser422, posLast=423423, posLast=424424, posLast=426426, Ser430, Thr433, posLast=434434, Ser458, Thr480, Thr484, posLast=514514, Thr541, posLast=548548, posLast=560560, posLast=561561, posLast=562562, Thr567, Ser570, Thr572, Ser578, posLast=599599, posLast=636636, Thr637, and posLast=638638
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD44 (CD44)
  • Abcam antibodies for CD44

Assay Products

  • Cloud-Clone Corp. Assay Kits for CD44

No data available for DME Specific Peptides for CD44 Gene

Domains & Families for CD44 Gene

Gene Families for CD44 Gene

HGNC:
Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CD44 Gene

Graphical View of Domain Structure for InterPro Entry

P16070

UniProtKB/Swiss-Prot:

CD44_HUMAN :
  • The lectin-like LINK domain is responsible for hyaluronan binding.
Domain:
  • The lectin-like LINK domain is responsible for hyaluronan binding.
genes like me logo Genes that share domains with CD44: view

Function for CD44 Gene

Molecular function for CD44 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD44 (Pgp-1),80-95kDa,identified by antibodies GRHL1,F10-44-2 (including MDU2,MDU3,MIC4 identified by monoclonal antibodies A1G3,13D8,F10.44),lymphocyte homing receptor,involved in extracellular matrix adhesion and in myeloid differentiation,expressed in small lymphocytic and mantle cell lymphoma,on leukemic blasts from most AML patients,and in invasive basal cell carcinomas
UniProtKB/Swiss-Prot Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).

Phenotypes From GWAS Catalog for CD44 Gene

Gene Ontology (GO) - Molecular Function for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 contributes_to cytokine receptor activity IDA 17045821
GO:0005515 protein binding IPI 11207560
GO:0005518 collagen binding NAS 2471973
GO:0005540 hyaluronic acid binding NAS,IEA 1991450
genes like me logo Genes that share ontologies with CD44: view
genes like me logo Genes that share phenotypes with CD44: view

Animal Models for CD44 Gene

MGI Knock Outs for CD44:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CD44
  • Applied Biological Materials Clones for CD44
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD44 Gene

Localization for CD44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD44 Gene

Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. {ECO:0000250 UniProtKB:P15379}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD44 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
golgi apparatus 5
cytoskeleton 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
lysosome 2
endosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS,IDA --
GO:0005887 integral component of plasma membrane NAS 1991450
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CD44: view

Pathways & Interactions for CD44 Gene

genes like me logo Genes that share pathways with CD44: view

SIGNOR curated interactions for CD44 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion NAS 1922057
GO:0016337 single organismal cell-cell adhesion NAS --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with CD44: view

Drugs & Compounds for CD44 Gene

(56) Drugs for CD44 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronic acid Approved, Vet_approved Pharma Target 503

(42) Additional Compounds for CD44 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD44: view

Transcripts for CD44 Gene

Unigene Clusters for CD44 Gene

CD44 molecule (Indian blood group):
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for CD44
  • Applied Biological Materials Clones for CD44
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CD44 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - -
SP10: - - - -
SP11: - - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - -
SP16: - - - -
SP17: - - - -
SP18: - - - -
SP19:
SP20:
SP21:
SP22: -
SP23: - - - - - - - - - -
SP24:
SP25: - - - -
SP26: - - - -
SP27:
SP28:
SP29: - - - - - - - - - - - - - - -
SP30:
SP31: -
SP32:
SP33:

ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - - -
SP16: - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - - - - - - -
SP19: - - - - -
SP20: - - - - - - - - - - - - -
SP21: - -
SP22:
SP23: - - - - - - - - - - - - - - - - - -
SP24:
SP25: - - - - - - - - - - - - - - - - - - - -
SP26: - - - - -
SP27: - - - - - - - - - - - - - - -
SP28:
SP29: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP30: - - -
SP31:
SP32:
SP33:

ExUns: 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b · 26c
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28: -
SP29: - -
SP30:
SP31:
SP32:
SP33: - - - - -

Relevant External Links for CD44 Gene

GeneLoc Exon Structure for
CD44
ECgene alternative splicing isoforms for
CD44

Expression for CD44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD44 Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for CD44 Gene

This gene is overexpressed in Nasal epithelium (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD44 Gene



NURSA nuclear receptor signaling pathways regulating expression of CD44 Gene:

CD44

SOURCE GeneReport for Unigene cluster for CD44 Gene:

Hs.502328

mRNA Expression by UniProt/SwissProt for CD44 Gene:

P16070-CD44_HUMAN
Tissue specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Evidence on tissue expression from TISSUES for CD44 Gene

  • Lung(5)
  • Nervous system(5)
  • Skin(4.9)
  • Blood(4.8)
  • Bone marrow(4.8)
  • Liver(4.8)
  • Pancreas(4.8)
  • Eye(4.7)
  • Kidney(4.4)
  • Intestine(4)
  • Stomach(3.9)
  • Lymph node(3.6)
  • Spleen(3.4)
  • Heart(3.2)
  • Muscle(2.8)
  • Bone(2.7)
  • Thyroid gland(2.6)
  • Adrenal gland(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with CD44: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD44 Gene

Orthologs for CD44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD44 33 34
  • 99.1 (n)
cow
(Bos Taurus)
Mammalia CD44 33 34
  • 87.69 (n)
dog
(Canis familiaris)
Mammalia CD44 33 34
  • 85.49 (n)
rat
(Rattus norvegicus)
Mammalia Cd44 33
  • 79.94 (n)
mouse
(Mus musculus)
Mammalia Cd44 33 16 34
  • 78.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CD44 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD44 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD44 33 34
  • 66.41 (n)