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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD44 Gene

protein-coding GIFtS: 70
GCID: GC11P035116

CD44 molecule (Indian blood group)

(Previous name: CD44 antigen (homing function and Indian blood group system)...)
(Previous symbols: MIC4, MDU2, MDU3)

Explore 223 diseases affiliated with
CD44 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD44 Molecule (Indian Blood Group)¹ ²		CD44 Antigen² ³
MDU2¹ ² ³ ⁵		GP90 Lymphocyte Homing/Adhesion Receptor² ³
MDU3¹ ² ³ ⁵		Hermes Antigen² ³
MIC4¹ ² ³ ⁵		CD44R¹
CSPG8¹ ²		CD44 Antigen (Homing Function And Indian Blood Group System)¹
HCELL¹ ²		CDW44²
IN¹ ²		Cell Surface Glycoprotein CD44²
MC56¹ ²		Chondroitin Sulfate Proteoglycan 8²
Pgp1¹ ²		Epican³
Extracellular Matrix Receptor III² ³		Hematopoietic Cell E- And L-Selectin Ligand²
Heparan Sulfate Proteoglycan² ³		Homing Function And Indian Blood Group System²
Hyaluronate Receptor² ³		CDw44³
Phagocytic Glycoprotein 1² ³		Epican³
ECMR-III² ³		PGP-1³
HUTCH-I² ³		PGP-I³
LHR² ³		Phagocytic Glycoprotein I³

External Ids:	HGNC: 1681¹	Entrez Gene: 960²	Ensembl: ENSG00000026508⁷	OMIM: 107269⁵	UniProtKB: P16070³

Export aliases for CD44 gene to outside databases

Previous GC identifers: GC11P036713 GC11P035838 GC11P035199 GC11P035124 GC11P035125 GC11P034858

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD44:

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and

migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin,

collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions

including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this

gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full

length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural

and functional diversity of this protein, and may be related to tumor metastasis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD44_HUMAN, P16070

Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for

HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix

metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression.

Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or

dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing

and post-translational modification events

Gene Wiki entry for CD44

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD44 gene promoter:
PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD44 promoter sequence

Search SABiosciences Chromatin IP Primers for CD44

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD44

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13

CD44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD44 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P035116: view genomic region (about GC identifiers)

Start:	35,160,417 bp from pter	End:	35,253,949 bp from pter
Size:	93,533 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD44_HUMAN, P16070 (See protein sequence)

Recommended Name: CD44 antigen precursor

Size: 742 amino acids; 81538 Da

Subunit: Interacts with PKN2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen,

laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2

via its C-terminal segment

Subcellular location: Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane

protrusions at wounding edges (By similarity)

3 PDB 3D structures from and Proteopedia for CD44:

1POZ (3D)

1UUH (3D)

2I83 (3D)

Secondary accessions: A5YRN9 B6EAT9 D3DR12 D3DR13 O95370 P22511 Q04858 Q13419 Q13957 Q13958 Q13959

Q13960 Q13961 Q13967 Q13968 Q13980 Q15861 Q16064 Q16065 Q16066 Q16208 Q16522 Q86T72 Q86Z27 Q8N694

Q92493 Q96J24 Q9H5A5 Q9UC28 Q9UC29 Q9UC30 Q9UCB0 Q9UJ36

Alternative splicing: 19 isoforms: P16070-1 P16070-2 P16070-3 P16070-4 P16070-5 P16070-6 P16070-7 P16070-8

P16070-9 P16070-10 P16070-11 P16070-12 P16070-13 P16070-14 P16070-15 P16070-16

P16070-17 P16070-18 P16070-19 (Soluble isoform, has enhanced hyaluronan binding)

Explore the universe of human proteins at neXtProt for CD44: NX_P16070

Post-translational modifications:

Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and

tumors¹

N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may

affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs

on Thr-637 or Thr-638¹

Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and

the phosphorylation of Ser-672¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P16070

CD44 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (8 alternative transcripts):

NP_000601.3 NP_001001389.1 NP_001001390.1 NP_001001391.1 NP_001001392.1 NP_001189484.1 NP_001189485.1 NP_001189486.1

ENSEMBL proteins:

ENSP00000263398 ENSP00000435377 ENSP00000389830 ENSP00000398632 ENSP00000395953

ENSP00000392331 ENSP00000278386 ENSP00000404447 ENSP00000309732 ENSP00000398099

ENSP00000432405 ENSP00000432704 ENSP00000434465 ENSP00000279452 ENSP00000434530

ENSP00000432718 ENSP00000433189 ENSP00000436549 ENSP00000436623 ENSP00000436980

ENSP00000278385 ENSP00000435321 ENSP00000436451 ENSP00000434418 ENSP00000431860

ENSP00000434920 ENSP00000414567 ENSP00000391008 ENSP00000403990 ENSP00000353280

Reactome Protein details: P16070
Human Recombinant Protein Products for CD44:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD44
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): CD44 OriGene Protein Over-expression Lysate (see all 4): CD44 OriGene Custom Protein Services for CD44
	GenScript Custom Purified and Recombinant Proteins Services for CD44
	Novus Biologicals CD44 Proteins Novus Biologicals CD44 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005794	Golgi apparatus	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	1991450
GO:0009897	external side of plasma membrane	IEA	--

CD44 for ontologies About GeneDecksing

CD44 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD44
	R&D Systems Antibodies for CD44
	Cell Signaling Technology (CST) Antibodies for CD44
	OriGene Antibodies (see all 3): CD44 OriGene Custom Antibody Services for CD44
	GenScript Custom Superior Antibodies Services for CD44
	Novus Biologicals CD44 Antibodies
	Abcam antibodies for CD44
	Browse Antibodies at Uscn
	ThermoFisher Antibody for CD44

Assay Products for CD44:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CD44
	GenScript Custom Assay Services for CD44
	Enzo Life Sciences assays for CD44
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD44 for domains About GeneDecksing

4 InterPro domains/families:

IPR000538 Link

IPR016187 C-type_lectin_fold

IPR016186 C-type_lectin-like

IPR001231 CD44_antigen

Graphical View of Domain Structure for InterPro Entry P16070

ProtoNet protein and cluster: P16070

2 Blocks protein families:

IPB000538 Link domain

IPB001231 CD44 antigen precursor signature

UniProtKB/Swiss-Prot: CD44_HUMAN, P16070

Domain: The lectin-like LINK domain is responsible for hyaluronan binding (By similarity)

Similarity: Contains 1 Link domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CD44_HUMAN, P16070

Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for

HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix

metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression.

Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or

dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing

and post-translational modification events

Genatlas biochemistry entry for CD44:

cell differentiation antigen CD44 (Pgp-1),80-95kDa,identified by antibodies GRHL1,F10-44-2 (including MDU2,MDU3,MIC4

identified by monoclonal antibodies A1G3,13D8,F10.44),lymphocyte homing receptor,involved in extracellular matrix

adhesion and in myeloid differentiation,expressed in small lymphocytic and mantle cell lymphoma,on leukemic blasts

from most AML patients,and in invasive basal cell carcinomas

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004415	hyalurononglucosaminidase activity	IDA	17170110
GO:0004888	contributes to transmembrane signaling receptor activity	IDA	17045821
GO:0005515	protein binding	IPI	--
GO:0005518	collagen binding	NAS	2471973
GO:0005540	hyaluronic acid binding	NAS	1991450

CD44 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CD44:

Decreased focal adhesion (FA)

15/23 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Cd44) (see all 23):

behavior/neurological	cardiovascular system	cellular	digestive/alimentary	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	integument
limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system

CD44 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CD44: Cd44^tm2.1Ugu Cd44^tm1.1Ugu Cd44^tm2Kmz Cd44^tm1Mak Cd44^tm1Ugu

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD44

miRNA Products:		miRTarBase miRNAs that target CD44: hsa-mir-608 (MIRT005967), hsa-mir-34a (MIRT005480), hsa-mir-199a-3p (MIRT003790), hsa-mir-373 (MIRT002428), hsa-mir-520c-3p (MIRT004082), hsa-mir-216a (MIRT005969), hsa-mir-330-3p (MIRT005968), hsa-mir-328 (MIRT000989)

		OriGene 3'-UTR Clone (see all 5): CD44 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD44
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate CD44 (see all 62):
		hsa-miR-579 hsa-miR-3164 hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-3146

		SwitchGear 3'UTR luciferase reporter plasmid: CD44 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD44 (see all 7) OriGene shRNA RFP: CD44 OriGene siRNA: CD44
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD44
		Sirion Biotech Custom design and validation of potent shRNA sequences against CD44

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CD44
			Sirion Biotech Customized adenovirus for overexpression of CD44 Sirion Biotech Customized adenovirus for potent knockdown of CD44

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD44 (see all 12) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD44 (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 8): CD44 (NM_001202555)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD44
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD44

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD44
		Search LifeMap BioReagents cell lines for CD44
		Sirion Biotech Customized stable knockdown cell line services for CD44 Sirion Biotech Customized inducible knockdown cell line services for CD44 Sirion Biotech Customized stable overexpressing cell line services for CD44 Sirion Biotech Customized inducible overexpressing cell line services for CD44

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD44

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/14 pathways (see all 14)
MPS VI - Maroteaux-Lamy syndrome	1.00	MPS VII - Sly syndrome	1.00
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS I - Hurler syndrome	1.00	MPS IIID - Sanfilippo syndrome D	1.00
Mucopolysaccharidoses	1.00	MPS IX - Natowicz syndrome	1.00

Hyaluronan uptake and degradation

	Hyaluronan uptake and degradation	1.00			Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments	0.60
	Hyaluronan metabolism	0.71

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Interferon gamma signaling

Interferon gamma signaling

1.00

Expression of IFNG-stimulated genes

0.72

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for CD44

	Development Beta-adrenergic receptors regulation of ERK
	Cell adhesion Cell-matrix glycoconjugates
	Signal transduction Calcium signaling
	Cell adhesion ECM remodeling

1 R&D Systems Pathway for CD44

Articular Cartilage Extracellular Matrix

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD44

	Rac1 Pathway
	Glioma Invasiveness

2 Cell Signaling Technology (CST) Pathways for CD44

	Lymphocyte Signaling
	Adhesion

4 GeneGo (Thomson Reuters) Pathways for CD44

	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion ECM remodeling
	Development Beta-adrenergic receptors regulation of ERK
	Signal transduction Calcium signaling

5 BioSystems Pathways for CD44

	Wnt Signaling Pathway and Pluripotency
	Senescence and Autophagy
	TGF-beta Receptor Signaling Pathway
	Paxillin-independent events mediated by a4b1 and a4b7
	Osteopontin-mediated events

5/24 Reactome Pathways for CD44 (see all 24)

	Hyaluronan metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	MPS IIIA - Sanfilippo syndrome A

3 Kegg Pathways (Kegg details for CD44):

	ECM-receptor interaction
	Hematopoietic cell lineage
	Shigellosis

CD44 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD44

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/143 Interacting proteins for CD44 (P16070^{1, 3} ENSP00000278385⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 143)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC7A11	Q9UPY5¹^,³, ENSP00000280612⁴	EBI-490245,EBI-3843348 I2D: score=1 STRING: ENSP00000280612
HBEGF	Q99075³, ENSP00000230990⁴	I2D: score=3 STRING: ENSP00000230990
LCK	P06239³, ENSP00000337825⁴	I2D: score=3 STRING: ENSP00000337825
MMP7	P09237³, ENSP00000260227⁴	I2D: score=3 STRING: ENSP00000260227
NF2	P35240³, ENSP00000344666⁴	I2D: score=3 STRING: ENSP00000344666

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001658	branching involved in ureteric bud morphogenesis	IEA	--
GO:0002246	wound healing involved in inflammatory response	IEA	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0007155	cell adhesion	--	--
GO:0007160	cell-matrix adhesion	NAS	1922057

CD44 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD44 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD44

1 HMDB Compound for CD44 About this table

Compound	Synonyms	CAS #	PubMed Ids
Hyaluronic acid	hyaluronic acid	9004-61-9	--

1 DrugBank Compound for CD44 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Hyaluronan	Hyaluronate (see all 4)	9067-32-7	target	--	--

10/98 Novoseek chemical compound relationships for CD44 gene (see all 98) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hyaluronic acid	84	381	15828943 (7), 17076095 (7), 11721159 (6), 9634638 (5) (see all 99)
glycosaminoglycan	70.9	35	9298694 (3), 7504022 (1), 7515731 (1), 9058710 (1) (see all 28)
chondroitin sulfate	59.1	66	10950950 (6), 9891023 (4), 8546427 (2), 8752662 (2) (see all 25)
matrigel	52.9	11	1906507 (2), 19724912 (2), 7518347 (2), 9815853 (1) (see all 7)
heparan sulfate	47.5	46	7532176 (7), 9891023 (4), 10950950 (2), 10583162 (2) (see all 16)
paraffin	46.1	19	15867228 (1), 9666819 (1), 9833394 (1), 10550296 (1) (see all 18)
slex	35.4	7	9430509 (2), 8547121 (1), 19651422 (1), 8838015 (1)
vegf	29.5	45	19638429 (5), 20073217 (3), 9893599 (3), 19017033 (2) (see all 25)
chondroitin	29.3	10	10950950 (3), 9334256 (1), 11821431 (1), 10222064 (1) (see all 6)
tunicamycin	28.7	3	8601595 (1), 10714394 (1), 9111868 (1)

Search CenterWatch for drugs/clinical trials and news about CD44

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD44 gene (8 alternative transcripts):

NM_000610.3 NM_001001389.1 NM_001001390.1 NM_001001391.1 NM_001001392.1 NM_001202555.1 NM_001202556.1 NM_001202557.1

Unigene Cluster for CD44:

CD44 molecule (Indian blood group)

Hs.502328 [show with all ESTs]

Unigene Representative Sequence: NM_000610

18/42 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 42):

ENST00000263398(uc001mvu.3 uc001mvv.3 uc001mvw.3 uc001mwc.4 uc001mvx.3 uc010rer.2 uc001mvy.3 uc009ykh.3)

ENST00000526025 ENST00000415148 ENST00000528086 ENST00000428726 ENST00000425428

ENST00000433892(uc010ret.2) ENST00000278386 ENST00000434472 ENST00000352818

ENST00000442151(uc021qfw.1) ENST00000525211 ENST00000526669 ENST00000526000

ENST00000279452 ENST00000527889 ENST00000531118 ENST00000528455

miRNA Products:		OriGene 3'-UTR Clone (see all 5): CD44 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD44
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate CD44 (see all 62):
		hsa-miR-579 hsa-miR-3164 hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-3146

		SwitchGear 3'UTR luciferase reporter plasmid: CD44 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD44 (see all 7) OriGene shRNA RFP: CD44 OriGene siRNA: CD44
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD44
		Sirion Biotech Custom design and validation of potent shRNA sequences against CD44

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD44 (see all 12) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD44 (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 8): CD44 (NM_001202555)
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Additional cDNA sequence:

AB073901.1 AF098641.1 AJ251595.1 AK127622.1 AK129808.1 AK290424.1 AK297776.1 AK304467.1

AK307707.1 AL832642.2 AY101192.1 AY101193.1 BC004372.1 BC052287.1 BC067348.1 D28447.1

EF581837.1 FJ216964.1 M24915.1 M25078.1 M59040.1 M83324.1 M83325.1 M83326.1

M83327.1 M83328.1 S66400.1 S82326.1 U40373.1 U94902.1 U94903.1 X55150.1

X55938.1 X56794.1 X62739.1 X66733.1

24/48 DOTS entries (see all 48):

DT.100684183 DT.97864832 DT.91789386 DT.95300618 DT.95300704 DT.100684179 DT.92461255 DT.100684175

DT.100684181 DT.87016134 DT.450200 DT.95300655 DT.100735366 DT.120740562 DT.120740539 DT.100664096

DT.100684170 DT.75143398 DT.40113924 DT.40129290 DT.86843055 DT.95300681 DT.120740557 DT.120740587

24/1216 AceView cDNA sequences (see all 1216):

BQ004566 BM742678 BU184888 CB124471 BP363182 AA305039 M83324 BM788191

BQ720761 CB120042 AA361671 BM766330 BM781491 AI292234 AA382096 BG680436

AA523003 BM799113 AA613095 CB138883 CA946461 NM_001001389 BM850850 AI369195

GeneLoc Exon Structure

5/33 Alternative Splicing Database (ASD) splice patterns (SP) for CD44 (see all 33) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11a	·
SP1:																																													-				-		-
SP2:																																													-		-		-		-
SP3:																																													-		-		-		-
SP4:																																													-		-		-		-
SP5:																																													-		-		-		-

ExUns:	11b	·	11c	·	11d	^	12	^	13	^	14a	·	14b	·	14c	·	14d	·	14e	^	15a	·	15b	·	15c	^	16a	·	16b	^	17a	·	17b	^	18	^	19a	·	19b	^	20a	·	20b	^	21	^	22a	·	22b	^	23a	·
SP1:	-				-		-				-														-		-		-																		-
SP2:	-				-		-				-														-		-		-																		-
SP3:	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-														-
SP4:	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	23b	^	24a	·	24b	·	24c	·	24d	^	25	^	26a	·	26b	·	26c
SP1:											-
SP2:											-
SP3:											-
SP4:											-
SP5:

ECgene alternative splicing isoforms for CD44

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD44 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGATTGGGG

About this image

CD44 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/23 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 23)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lateral Plate Mesoderm

Aorta-Gonad-Mesonephros

Hematopoietic Stem Cells

Selective marker (cell-identifying gene)

Blood

Liver

Liver Bud

Hematopoietic Stem Cells

Blood

Bone

Autopod Perichondrium

Endochondral Preosteoblasts

Bone

Cervical Vertebrae

Endochondral Preosteoblasts

Bone

Lumbar Vertebrae

Endochondral Preosteoblasts

Bone

Sacral Vertebrae

Endochondral Preosteoblasts

Bone

Stylopod Perichondrium

Endochondral Preosteoblasts

Bone

Thoracic Rib

Endochondral Preosteoblasts

Bone

Thoracic Vertebrae

Endochondral Preosteoblasts

Bone

Zeugopod Perichondrium

Endochondral Preosteoblasts

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/23 LifeMap Cells (see all 23)

Name

Category

Human multipotent adipose-derived (hMAD) stem cells (Adult Stem / Progenitor Cell)

Adipose

Adipose-derived mesenchymal stem cells (Adult Stem / Progenitor Cell)

Adipose

Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)

Bone

Bone marrow-derived mesenchymal stem cells (Lonza) (Adult Stem / Progenitor Cell)

Bone

Human bone marrow-derived mesenchymal stem cells (Adult Stem / Progenitor Cell)

Bone

Parietal epithelial cells (PEC) (Adult Stem / Progenitor Cell)

Epithelium, Kidney

Adult human kidney epithelial cells (Primary Cell)

Kidney

Endometrial regenerative cell (Adult Stem / Progenitor Cell)

Reproductive System

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

See CD44 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD44

SOURCE GeneReport for Unigene cluster: Hs.502328

UniProtKB/Swiss-Prot: CD44_HUMAN, P16070

Tissue specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by

carcinomas. Expression is repressed in neuroblastoma cells

SABiosciences Expression via Pathway-Focused PCR Arrays including CD44 (see all 17):

Parkinson's Disease in human mouse rat

HIV Host Response in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Cell Surface Markers in human mouse rat

Multiple Sclerosis in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD44 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd44^{1 , 5}	CD44 antigen^{1, 5}	79.44(n)¹ 71.47(a)¹		2 (54.13 cM)⁵ 12505¹ NM_009851.2¹ NP_033981.2¹ 102811141⁵
chicken (Gallus gallus)	Aves	CD44¹	CD44 molecule (Indian blood group)	60.48(n) 54.72(a)		395666 NM_204860.2 NP_990191.2
lizard (Anolis carolinensis)	Reptilia	CD44⁶	--	42(a)	1 ↔ 1	1(54805519-54854221)
African clawed frog (Xenopus laevis)	Amphibia	CD361163.1²	--	70.78(n)		CD361163.1
zebrafish (Danio rerio)	Actinopterygii	LOC100330801¹	uncharacterized LOC100330801	50.4(n) 36.14(a)		100330801 XM_002666970.1 XP_002667016.1

ENSEMBL Gene Tree for CD44 (if available)
TreeFam Gene Tree for CD44 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD44 gene

LYVE1²

CD44 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: CD44_HUMAN, P16070

Polymorphism: CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2

blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75218872^1,2	C,F	--	34856991(+)	`TCACAT/CTGCTC`	9	--	us2k¹ int¹		1		WA	118
rs113354372^1,2		--	34857329(+)	`TGTTCG/ATCACT`	9	--	us2k¹ int¹		1		CSA	2
rs73453623^1,2	C	--	34857357(+)	`GATGAC/GTTACT`	9	--	int¹ us2k¹		2		WA	120
rs78408380^1,2		--	34857410(+)	`TTGAGG/TCCTGC`	9	--	int¹ us2k¹		1		WA	118
rs61327674^1,2		--	34857613(+)	`TACCTC/TGATAC`	9	--	int¹ us2k¹		0	--	--	--	--
rs112838149^1,2		--	34857742(+)	`CTGGCA/GTGGTT`	9	--	us2k¹ nc-transcript-variant		2		CSA WA	120
rs57187260^1,2	C	--	34857800(+)	`AACTC-/ACCAGG`	9	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs7944409^1,2	C,F,H	--	34857830(+)	`TACTTT/GTAGTA`	9	--	us2k¹ nc-transcript-variant		11		NS EA NA WA CSA	1214
rs61056680^1,2	C	--	34857904(+)	`AGATAT/CAGAGT`	9	--	nc-transcript-variantus2k¹		2		WA	120
rs76749023^1,2	F	--	34858668(+)	`CCCACC/ACCTCA`	9	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for CD44 (35160417 - 35253949 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CD44
3 CNVs: 85721 3844 2918
Human Gene Mutation Database (HGMD): CD44
Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

SABiosciences Cancer Mutation PCR Assays

2 SABiosciences qBiomarker Copy Number PCR Arrays containing CD44:

Oncogenes & Tumor Suppressor Genes 384HC

Gastric Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD44

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD44 for disorders           About GeneDecksing

OMIM gene information: 107269    OMIM disorders: --

20/223 diseases for CD44 (see all 223):    About MalaCards

malignant peripheral nerve sheath tumor spinal cord astrocytoma diffuse large b-cell lymphoma human t-cell leukemia virus type 1

hypersensitivity reaction type ii disease hematopoiesis lichen sclerosus gliomatosis cerebri

wiskott-aldrich syndrome squamous cell carcinoma non-small cell lung carcinoma lichen planus

b-cell lymphomas nonpapillary renal cell carcinoma laryngeal squamous cell carcinoma follicular mucinosis

dry eye syndrome dyserythropoietic anemia smooth muscle tumor oral lichen planus

14 diseases from the University of Copenhagen DISEASES database for CD44:

Carcinoma Breast cancer Colorectal cancer Prostate cancer

Leukemia Lymphoma Arthritis Pancreatic cancer

Melanoma Ovarian cancer Malignant glioma Hypersensitivity reaction type II disease

Lung cancer Kidney disease

10/94 Novoseek disease relationships for CD44 gene (see all 94) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	78.3	546	11005492 (8), 9772282 (5), 11582589 (5), 17912438 (4) (see all 99)
tumors	73.6	1071	17912438 (8), 10200702 (8), 8579108 (7), 11839564 (7) (see all 99)
carcinoma	64.7	229	8567994 (5), 12534600 (4), 9826464 (4), 10547541 (3) (see all 99)
cancer	61.5	294	11832714 (6), 11313172 (4), 9090502 (3), 7518345 (3) (see all 99)
primary tumor	57.2	38	14666731 (3), 8682582 (2), 17006832 (2), 12854146 (2) (see all 26)
colon carcinoma	54.2	55	18234849 (4), 8678563 (4), 11431370 (3), 8858111 (3) (see all 29)
colorectal carcinoma	53.2	64	12782013 (4), 7504563 (3), 9754757 (3), 11911305 (3) (see all 33)
adenocarcinoma	52.7	98	7537174 (5), 8599448 (4), 15717748 (4), 8608952 (3) (see all 61)
aggressiveness	52.1	31	7576964 (3), 10846530 (3), 10355528 (2), 11213839 (1) (see all 20)
carcinoma squamous cell	50.2	72	17679465 (4), 19900133 (3), 9725567 (3), 8599448 (2) (see all 45)

Genetic Association Database (GAD): CD44
Human Genome Epidemiology (HuGE) Navigator: CD44 (24 documents)

Export disorders for CD44 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD44 gene, integrated from 9 sources (see all 2115):
(articles sorted by number of sources associating them with CD44)

Utopia: connect your pdf to the dynamic
world of online information

Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase. (PubMed id 8352881)^{1, 2, 9} Tanabe K.K.... Saya H. (1993)
Expression of CD44 is repressed in neuroblastoma cells. (PubMed id 1922057)^{1, 2, 9} Shtivelman E. and Bishop J.M. (1991)
Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44. (PubMed id 10933060)^{1, 2, 9} Chiu R.K....Dougherty G.J. (1999)
Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325. (PubMed id 9580567)^{1, 2, 9} Peck D. and Isacke C.M. (1998)
CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. (PubMed id 1717145)^{1, 2, 9} Hofmann M....Guenthert U. (1991)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Ligand-induced structural changes of the CD44 hyaluronan-binding domain revealed by NMR. (PubMed id 17085435)^{1, 2} Takeda M.... Shimada I. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. (PubMed id 14992719)^{1, 2} Teriete P.... Jackson D.G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 960	HGNC: 1681	AceView: CD44	Ensembl:ENSG00000026508	euGenes: HUgn960
ECgene: CD44	Kegg: 960	H-InvDB: CD44

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD44	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD44	Genetics and Cytogenetics in Oncology and Haematology
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=indian
Wikipedia	http://en.wikipedia.org/wiki/CD44

Intellectual Property for CD44 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CD44 gene:
Search GeneIP for patents involving CD44

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

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CD44 molecule (Indian blood group)

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CD44 (Gene Symbol)
CD44 Molecule (Indian Blood Group)
MDU2
MDU3
MIC4
CSPG8
HCELL
IN
MC56
Pgp1
Extracellular Matrix Receptor III
Heparan Sulfate Proteoglycan
Hyaluronate Receptor
Phagocytic Glycoprotein 1
ECMR-III
HUTCH-I
LHR
CD44 Antigen
GP90 Lymphocyte Homing/Adhesion Receptor
Hermes Antigen
CD44R
CD44 Antigen (Homing Function And Indian Blood Group System)
CDW44
Cell Surface Glycoprotein CD44
Chondroitin Sulfate Proteoglycan 8
Epican
Hematopoietic Cell E- And L-Selectin Ligand
Homing Function And Indian Blood Group System
CDw44
Epican
PGP-1
PGP-I
Phagocytic Glycoprotein I

Brain Tumor Primary
Renal Cancer
nonmetastatic
Carcinoma Basal Cell
Lymphoma T-Cell
dysplasia
Lichen Sclerosus
aggressiveness
COLON CARCINOMA
Multiple tumors
LUNG CARCINOMA
Lymphatic Metastasis
Metaplasia
Breast Cancer
primary tumor
brain metastases
NSCLC
Adenocarcinoma
Anemia Dyserythropoietic Congenital
Ganglioneuroblastoma
Carcinoma Transitional Cell
Cancer
premalignant
Colorectal Carcinoma
ADENOCARCINOMA GASTRIC
Lymphoma
Carcinoma Non-Small Cell Lung
GASTRIC CARCINOMA
Ovarian Cancer
Colorectal Neoplasms
Precancerous lesions
Colorectal Cancer
Inflammation
HNSCC
Burkitt Lymphoma
invasive cancer
Cervical Cancer
MYELOMA
ENDOMETRIAL CARCINOMA
Rheumatoid Arthritis
Neurofibromatosis Type 2
prostate cancer
Tumors
Metastasis
prostatic adenocarcinoma
Necrosis
Glioblastoma
Colonic Crohns disease
neoplastic transformation
Malignant Glioma
COLON TUMOR
Gastric Cancer
Glioblastoma Multiforme
Brain Tumors
BREAST CARCINOMA
Melanoma
Colon Cancer
bladder cancer
Malignant Peripheral Nerve Sheath Tumors
Adenoma Follicular
Glioma
Adenomatous Polyps
Squamous Cell Cancer
Astrocytoma
Carcinoma
epithelial tumor
PROSTATE CARCINOMA
Leukemia
ductal breast carcinoma
metastatic cancer
Carcinoma Papillary
CERVICAL CARCINOMA
THYROID PAPILLARY CARCINOMA
laryngeal squamous cell carcinoma
Carcinoma Renal Cell
Cancer Lung
small cell lung cancer
aggressive behavior
Lymphoma B-Cell
Adenoma
Ganglioneuroma
OVARIAN CARCINOMA
Prostatic Intraepithelial Neoplasia
Lymphocytic Leukemia Chronic B-Cell
Carcinoma Squamous Cell
Colorectal Tumors
BLADDER CARCINOMA
neuroblastoma metastatic
Lymphoma Large Cell Diffuse
PANCREATIC CARCINOMA
plasma cell myeloma
Lymphoma Non-Hodgkins
LEUKAEMIA LYMPHOCYTIC
Endometrial Cancer

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CD44 Gene

CD44 molecule (Indian blood group)

Aliasesfor CD44 gene

Summariesfor CD44 gene

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Proteinsfor CD44 gene

Protein Domains /Familiesfor CD44 gene

Functionfor CD44 gene

Pathways & Interactionsfor CD44 gene

Drugs & Compoundsfor CD44 gene

Transcriptsfor CD44 gene

Expression for CD44 gene

Orthologsfor CD44 gene

Paralogsfor CD44 gene

Genomic Variantsfor CD44 gene

Disorders / Diseasesfor CD44 gene

Publicationsfor CD44 gene

External Searches for CD44 gene

Genome Databases showing CD44 gene

Other Databases showing CD44 gene

Specialized Databases showing CD44 gene

Intellectual Propertyfor CD44 gene

Productsfor CD44 gene

View Random Gene

Aliases
for CD44 gene

Summaries
for CD44 gene

Genomic Views
for CD44 gene

Proteins
for CD44 gene

Protein Domains /
Families
for CD44 gene

Function
for CD44 gene

Pathways & Interactions
for CD44 gene

Drugs & Compounds
for CD44 gene

Transcripts
for CD44 gene

Expression
for CD44 gene

Orthologs
for CD44 gene

Paralogs
for CD44 gene

Genomic Variants
for CD44 gene

Disorders / Diseases
for CD44 gene

Publications
for CD44 gene

Intellectual Property
for CD44 gene

Products
for CD44 gene