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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD44 Gene

protein-coding   GIFtS: 71
GCID: GC11P035116

CD44 Molecule (Indian Blood Group)

(Previous name: CD44 antigen (homing function and Indian blood group system))
(Previous symbols: MIC4, MDU2, MDU3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD44 Molecule (Indian Blood Group)1 2     CD44 Antigen (Homing Function And Indian Blood Group System)1
MDU21 2 3 5     CDW442
MDU31 2 3 5     CSPG82
MIC41 2 3 5     HCELL2
Chondroitin Sulfate Proteoglycan 81 2     IN2
Hematopoietic Cell E- And L-Selectin Ligand1 2     MC562
Extracellular Matrix Receptor III2 3     Pgp12
Heparan Sulfate Proteoglycan2 3     Cell Surface Glycoprotein CD442
Hyaluronate Receptor2 3     epican2
Phagocytic Glycoprotein 12 3     Homing Function And Indian Blood Group System2
ECMR-III2 3     CDw443
HUTCH-I2 3     Epican3
LHR2 3     PGP-13
CD44 Antigen2 3     PGP-I3
GP90 Lymphocyte Homing/Adhesion Receptor2 3     Phagocytic Glycoprotein I3
Hermes Antigen2 3     

External Ids:    HGNC: 16811   Entrez Gene: 9602   Ensembl: ENSG000000265087   OMIM: 1072695   UniProtKB: P160703   

Export aliases for CD44 gene to outside databases

Previous GC identifers: GC11P036713 GC11P035838 GC11P035199 GC11P035124 GC11P035125 GC11P034858


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD44 Gene:
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion
and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as
osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of
cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor
metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally
distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative
splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor
metastasis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD44 Gene: 
CD44 (CD44 molecule (Indian blood group)) is a protein-coding gene. Diseases associated with CD44 include superficial keratitis, and spinal cord astrocytoma, and among its related super-pathways are Syndecan interactions and Metabolism of carbohydrates. GO annotations related to this gene include transmembrane signaling receptor activity and hyaluronic acid binding. An important paralog of this gene is LYVE1.

UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity
for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix
metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and
progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered
expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous
alternative splicing and post-translational modification events

Gene Wiki entry for CD44 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD44 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD44 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD44

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

CD44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD44 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P035116:  view genomic region     (about GC identifiers)

Start:
35,160,417 bp from pter      End:
35,253,949 bp from pter
Size:
93,533 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD44_HUMAN, P16070 (See protein sequence)
Recommended Name: CD44 antigen precursor  
Size: 742 amino acids; 81538 Da
Subunit: Interacts with PKN2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen,
laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN),
and NF2 via its C-terminal segment
Subcellular location: Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane
protrusions at wounding edges (By similarity)
3 PDB 3D structures from and Proteopedia for CD44:
1POZ (3D)        1UUH (3D)        2I83 (3D)    
Secondary accessions: A5YRN9 B6EAT9 D3DR12 D3DR13 O95370 P22511 Q04858 Q13419 Q13957 Q13958
Q13959 Q13960 Q13961 Q13967 Q13968 Q13980 Q15861 Q16064 Q16065 Q16066 Q16208 Q16522 Q86T72
Q86Z27 Q8N694 Q92493 Q96J24 Q9H5A5 Q9UC28 Q9UC29 Q9UC30 Q9UCB0 Q9UJ36
Alternative splicing: 19 isoforms:  P16070-1   P16070-2   P16070-3   P16070-4   P16070-5   P16070-6   P16070-7   P16070-8   
P16070-9   P16070-10   P16070-11   P16070-12   P16070-13   P16070-14   P16070-15   P16070-16   
P16070-17   P16070-18   P16070-19   (Soluble isoform, has enhanced hyaluronan binding)

Explore the universe of human proteins at neXtProt for CD44: NX_P16070

Explore proteomics data for CD44 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines
    and tumors
  • UniProtKB: N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number
    may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if
    O-glycosylation occurs on Thr-637 or Thr-638
  • UniProtKB: Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site),
    and the phosphorylation of Ser-672
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16070

  • CD44 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD44 Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_000601.3  NP_001001389.1  NP_001001390.1  NP_001001391.1  NP_001001392.1  NP_001189484.1  NP_001189485.1  NP_001189486.1  

    ENSEMBL proteins: 
     ENSP00000263398   ENSP00000435377   ENSP00000389830   ENSP00000398632   ENSP00000432704  
     ENSP00000395953   ENSP00000392331   ENSP00000278386   ENSP00000404447   ENSP00000309732  
     ENSP00000398099   ENSP00000432405   ENSP00000434465   ENSP00000279452   ENSP00000434530  
     ENSP00000432718   ENSP00000433189   ENSP00000436549   ENSP00000436623   ENSP00000436980  
     ENSP00000278385   ENSP00000435321   ENSP00000436451   ENSP00000434418   ENSP00000431860  
     ENSP00000434920   ENSP00000414567   ENSP00000391008   ENSP00000403990   ENSP00000353280  
    Reactome Protein details: P16070
    Human Recombinant Protein Products for CD44: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD44
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CD44
    OriGene Protein Over-expression Lysate for CD44
    OriGene MassSpec for CD44 
    OriGene Custom Protein Services for CD44
    GenScript Custom Purified and Recombinant Proteins Services for CD44
    Novus Biologicals CD44 Proteins
    Novus Biologicals CD44 Lysates
    Sino Biological Recombinant Protein for CD44
    Sino Biological Cell Lysate for CD44 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS1991450
    GO:0009897external side of plasma membrane IEA--

    CD44 for ontologies           About GeneDecksing



    CD44 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD44
    R&D Systems Antibodies for CD44
    Cell Signaling Technology (CST) Antibodies for CD44 
    OriGene Antibodies for CD44
    OriGene Custom Antibody Services for CD44
    GenScript Custom Superior Antibodies Services for CD44
    Novus Biologicals CD44 Antibodies
    Abcam antibodies for CD44
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CD44
    LSBio Antibodies in human, mouse, rat for CD44 

    Assay Products for CD44: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD44
    R&D Systems Proteome Profiler Antibody Arrays for CD44
    GenScript Custom Assay Services for CD44
    Enzo Life Sciences assays for CD44
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CSPG: Proteoglycans / Cell surface : Other
    CD: CD molecules
    bloodgroup: Blood group antigens

    4 InterPro protein domains:
     IPR000538 Link
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001231 CD44_antigen

    Graphical View of Domain Structure for InterPro Entry P16070

    ProtoNet protein and cluster: P16070

    2 Blocks protein domains:
    IPB000538 Link domain
    IPB001231 CD44 antigen precursor signature


    UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
    Domain: The lectin-like LINK domain is responsible for hyaluronan binding (By similarity)
    Similarity: Contains 1 Link domain


    CD44 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD44_HUMAN, P16070
    Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity
    for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix
    metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and
    progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered
    expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous
    alternative splicing and post-translational modification events

         Genatlas biochemistry entry for CD44:
    cell differentiation antigen CD44 (Pgp-1),80-95kDa,identified by antibodies GRHL1,F10-44-2 (including
    MDU2,MDU3,MIC4 identified by monoclonal antibodies A1G3,13D8,F10.44),lymphocyte homing receptor,involved in
    extracellular matrix adhesion and in myeloid differentiation,expressed in small lymphocytic and mantle cell
    lymphoma,on leukemic blasts from most AML patients,and in invasive basal cell carcinomas

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004415hyalurononglucosaminidase activity IDA17170110
    GO:0004888contributes to transmembrane signaling receptor activity IDA17045821
    GO:0005515protein binding IPI11207560
    GO:0005518collagen binding NAS2471973
    GO:0005540hyaluronic acid binding NAS1991450
         
    CD44 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD44:
     Decreased focal adhesion (FA)  

         15/23 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Cd44) (see all 23):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  liver/biliary system  mortality/aging  muscle  nervous system 

    CD44 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD44: Cd44tm2.1Ugu Cd44tm1.1Ugu Cd44tm2Kmz Cd44tm1Mak Cd44tm1Ugu

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD44 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD44

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD44 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD44 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD44:
    hsa-mir-608 (MIRT005967), hsa-mir-34a (MIRT005480), hsa-mir-199a-3p (MIRT003790), hsa-mir-373 (MIRT002428), hsa-mir-520c-3p (MIRT004082), hsa-mir-216a (MIRT005969), hsa-mir-330-3p (MIRT005968), hsa-mir-328 (MIRT000989)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD44
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate CD44 (see all 62):
    hsa-miR-579 hsa-miR-3164 hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-3146
    SwitchGear 3'UTR luciferase reporter plasmidCD44 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD44
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD44

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD44
    Sirion Biotech Customized adenovirus for overexpression of CD44

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD44 (see all 35)
    OriGene ORF clones in mouse, rat for CD44
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): CD44 (NM_001202555)
    Sino Biological Human cDNA Clone for CD44
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD44
    Sirion Biotech Customized lentivirus for stable overexpression of CD44 
                         Customized lentivirus expression plasmids for stable overexpression of CD44 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD44
    Search LifeMap BioReagents cell lines for CD44
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD44


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD44 About   (see all 27)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.44
    ECM-receptor interaction0.42
    2MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Mucopolysaccharidoses0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS IV - Morquio syndrome B0.48
    MPS I - Hurler syndrome0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS IX - Natowicz syndrome0.48
    3Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61
    4Hyaluronan uptake and degradation
    Hyaluronan uptake and degradation0.71
    Hyaluronan metabolism0.71
    5Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for CD44
        Development Beta-adrenergic receptors regulation of ERK
    Cell adhesion Cell-matrix glycoconjugates
    Signal transduction Calcium signaling
    Cell adhesion ECM remodeling

    2 R&D Systems Pathways for CD44
        Articular Cartilage Extracellular Matrix
    VEGF - VEGF R2 Signaling Pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD44
        Rac1 Pathway
    Glioma Invasiveness

    2 Cell Signaling Technology (CST) Pathways for CD44
        Lymphocyte Signaling
    Adhesion

    4 GeneGo (Thomson Reuters) Pathways for CD44
        Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion ECM remodeling
    Development Beta-adrenergic receptors regulation of ERK
    Signal transduction Calcium signaling

    5 BioSystems Pathways for CD44
        Senescence and Autophagy
    Wnt Signaling Pathway and Pluripotency
    TGF-beta Receptor Signaling Pathway
    Osteopontin-mediated events
    Paxillin-independent events mediated by a4b1 and a4b7


    5/24        Reactome Pathways for CD44 (see all 24)
        Hyaluronan metabolism
    MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    MPS IIIA - Sanfilippo syndrome A


    5/6         Kegg Pathways  (Kegg details for CD44) (see all 6):
        ECM-receptor interaction
    Hematopoietic cell lineage
    Shigellosis
    Epstein-Barr virus infection
    Proteoglycans in cancer


    CD44 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD44

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/143 Interacting proteins for CD44 (P160701, 3 ENSP000002783854) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC7A11Q9UPY51, 3, ENSP000002806124EBI-490245,EBI-3843348 I2D: score=1 STRING: ENSP00000280612
    HBEGFQ990753, ENSP000002309904I2D: score=3 STRING: ENSP00000230990
    LCKP062393, ENSP000003378254I2D: score=3 STRING: ENSP00000337825
    MMP7P092373, ENSP000002602274I2D: score=3 STRING: ENSP00000260227
    NF2P352403, ENSP000003446664I2D: score=3 STRING: ENSP00000344666
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0002246wound healing involved in inflammatory response IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007155cell adhesion ----
    GO:0007160cell-matrix adhesion NAS1922057

    CD44 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD44 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD44

    1 HMDB Compound for CD44    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hyaluronic acidhyaluronic acid 9004-61-9--

    1 DrugBank Compound for CD44    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HyaluronanHyaluronate (see all 4)9067-32-7target----

    10/98 Novoseek inferred chemical compound relationships for CD44 gene (see all 98)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 84 381 15828943 (7), 17076095 (7), 11721159 (6), 9634638 (5) (see all 99)
    glycosaminoglycan 70.9 35 9298694 (3), 7504022 (1), 7515731 (1), 9058710 (1) (see all 28)
    chondroitin sulfate 59.1 66 10950950 (6), 9891023 (4), 8546427 (2), 8752662 (2) (see all 25)
    matrigel 52.9 11 1906507 (2), 19724912 (2), 7518347 (2), 9815853 (1) (see all 7)
    heparan sulfate 47.5 46 7532176 (7), 9891023 (4), 10950950 (2), 10583162 (2) (see all 16)
    paraffin 46.1 19 15867228 (1), 9666819 (1), 9833394 (1), 10550296 (1) (see all 18)
    slex 35.4 7 9430509 (2), 8547121 (1), 19651422 (1), 8838015 (1)
    vegf 29.5 45 19638429 (5), 20073217 (3), 9893599 (3), 19017033 (2) (see all 25)
    chondroitin 29.3 10 10950950 (3), 9334256 (1), 11821431 (1), 10222064 (1) (see all 6)
    tunicamycin 28.7 3 8601595 (1), 10714394 (1), 9111868 (1)

    Search CenterWatch for drugs/clinical trials and news about CD44

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD44 gene (8 alternative transcripts): 
    NM_000610.3  NM_001001389.1  NM_001001390.1  NM_001001391.1  NM_001001392.1  NM_001202555.1  NM_001202556.1  NM_001202557.1  

    Unigene Cluster for CD44:

    CD44 molecule (Indian blood group)
    Hs.502328  [show with all ESTs]
    Unigene Representative Sequence: NM_000610
    18/42 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 42):
    ENST00000263398(uc001mvu.3 uc001mvv.3 uc001mvw.3 uc001mwc.4 uc001mvx.3 uc010rer.2 uc001mvy.3 uc009ykh.3)
    ENST00000526025 ENST00000415148 ENST00000528086 ENST00000428726 ENST00000526669
    ENST00000425428 ENST00000433892(uc010ret.2) ENST00000278386 ENST00000434472
    ENST00000352818 ENST00000442151(uc021qfw.1) ENST00000525211 ENST00000526000
    ENST00000279452 ENST00000527889 ENST00000531118 ENST00000528455
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD44
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate CD44 (see all 62):
    hsa-miR-579 hsa-miR-3164 hsa-miR-548j hsa-miR-302d hsa-miR-520e hsa-miR-607 hsa-miR-300 hsa-miR-3146
    SwitchGear 3'UTR luciferase reporter plasmidCD44 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD44
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD44
    Clone
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    OriGene clones in human, mouse for CD44 (see all 35)
    OriGene ORF clones in mouse, rat for CD44
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    Sirion Biotech Customized lentivirus for stable overexpression of CD44 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD44

    Additional mRNA sequence: 

    AB073901.1 AF098641.1 AJ251595.1 AK127622.1 AK129808.1 AK290424.1 AK297776.1 AK304467.1 
    AK307707.1 AL832642.2 AY101192.1 AY101193.1 BC004372.1 BC052287.1 BC067348.1 D28447.1 
    EF581837.1 FJ216964.1 M24915.1 M25078.1 M59040.1 M83324.1 M83325.1 M83326.1 
    M83327.1 M83328.1 S66400.1 S82326.1 U40373.1 U94902.1 U94903.1 X55150.1 
    X55938.1 X56794.1 X62739.1 X66733.1 

    24/48 DOTS entries (see all 48):

    DT.100684183  DT.97864832  DT.91789386  DT.95300618  DT.95300704  DT.100684179  DT.92461255  DT.100684175 
    DT.100684181  DT.87016134  DT.450200  DT.95300655  DT.100735366  DT.120740562  DT.120740539  DT.100664096 
    DT.100684170  DT.75143398  DT.40113924  DT.40129290  DT.86843055  DT.95300681  DT.120740557  DT.75100374 

    24/1216 AceView cDNA sequences (see all 1216):

    BC067348 AA576970 AW780248 BP363851 NM_001001391 AF098641 AA665779 T25094 
    BU657041 CD365638 AW517914 AI950633 AA305039 AI796964 BU150725 AI246771 
    BM764468 AW572619 AI085455 BM742678 AA523003 BM552398 BU168480 BM853235 

    GeneLoc Exon Structure

    5/33 Alternative Splicing Database (ASD) splice patterns (SP) for CD44 (see all 33)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
    SP1:                                                                                                                                      -           -     -   
    SP2:                                                                                                                                      -     -     -     -   
    SP3:                                                                                                                                      -     -     -     -   
    SP4:                                                                                                                                      -     -     -     -   
    SP5:                                                                                                                                      -     -     -     -   

    ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
    SP1:  -           -     -           -                                         -     -     -                                                     -               
    SP2:  -           -     -           -                                         -     -     -                                                     -               
    SP3:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                         -               
    SP4:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -               
    SP5:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -               

    ExUns: 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b · 26c
    SP1:                                -                     
    SP2:                                -                     
    SP3:                                -                     
    SP4:                                -                     
    SP5:                                                      


    ECgene alternative splicing isoforms for CD44

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD44 expression in normal human tissues (normalized intensities)      CD44 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATTGGGG
    CD44 Expression
    About this image


    CD44 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 28 entries
             Bone Marrow Stromal Cells Bone Marrow
             Bone marrow-derived lineage-negative cells
             Chondrocyte-like cells ( Direct differentiation of human embryonic stem cells into...
     
     Mesenchymal Stem Cells
             Decidua-derived mesenchymal stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 13 entries
             Mesenchymal Stem Cells Cord Blood
             Umbilical cord blood-derived mesenchymal stem cells
             Enriched erythrocyte-like cells ( Generation and expansion of erythroid cells )
     
     Cartilage (Muscoskeletal System)    fully expand to see all 12 entries
             Bone Marrow Stromal Cells Bone Marrow
             Chondrocyte-like cells ( Direct differentiation of human embryonic stem cells into...
     
     Adipose (Muscoskeletal System)    fully expand to see all 11 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Adipose-derived stromal cells

    See CD44 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD44

    SOURCE GeneReport for Unigene cluster: Hs.502328

    UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
    Tissue specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by
    carcinomas. Expression is repressed in neuroblastoma cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD44 (see all 17): 
              Parkinson's Disease in human mouse rat
              HIV Host Response in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Multiple Sclerosis in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD44

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD44 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd441 , 5 CD44 antigen1, 5 79.44(n)1
    71.47(a)1
      2 (54.13 cM)5
    125051  NM_009851.21  NP_033981.21 
     1028111415 
    chicken
    (Gallus gallus)
    Aves CD441 CD44 molecule (Indian blood group) 60.48(n)
    54.72(a)
      395666  NM_204860.2  NP_990191.2 
    lizard
    (Anolis carolinensis)
    Reptilia CD446
    Uncharacterized protein
    41(a)
    1 ↔ 1
    1(54803137-54854221)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD361163.12   -- 70.78(n)    CD361163.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003308011 uncharacterized LOC100330801 50.4(n)
    36.14(a)
      100330801  XM_002666970.1  XP_002667016.1 


    ENSEMBL Gene Tree for CD44 (if available)
    TreeFam Gene Tree for CD44 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD44 gene
    LYVE12  

    CD44 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CD44_HUMAN, P16070
    Polymorphism: CD44 is responsible for the Indian blood group system. The molecular basis of the
    In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele,
    has Arg-46


    10/3411 SNPs in CD44 are shown (see all 3411)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219095451,2
    Cnon-pathogenic135126765(+) TCTCTC/GGGACG 16 R G mis10--------
    VAR_0064904
    ----see VAR_0064902 R P mis40--------
    rs792508951,2
    C--34897203(+) AAAAAA/TTTTTT 8 -- int10--------
    rs2003413311,2
    --34901810(+) AAATT-/TATATAT 8 -- int10--------
    rs1905323541,2
    --34901927(+) ATATAA/TTATAT 8 -- int10--------
    rs106757821,2
    C--34901947(+) tatat-/A/AT  
            
    tatat
    8 -- int10--------
    rs30474781,2
    C--34905592(-) GGAGGGAGG/-  
            
    AAGAC
    8 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs349104821,2
    C--34905605(+) CCCTC-/CCC   
      T
    /CCTC
    TCTCC
    8 -- int10--------
    rs30474761,2
    C--34906539(-) TAAGA-/TAGACAC 8 -- int10--------
    rs114484301,2
    C--34918993(+) AAAAA-/AAAAAA 8 -- int1 trp31Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for CD44 (35160417 - 35253949 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CD44:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744344CNV Deletion23290073
    nsv39411CNV Insertion16902084
    nsv508623CNV Loss20534489
    dgv1072n71CNV Gain21882294
    dgv1071n71CNV Gain21882294
    dgv361e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): CD44
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing CD44:
    Oncogenes & Tumor Suppressor Genes 384HC
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing CD44
    DNA2.0 Custom Variant and Variant Library Synthesis for CD44

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107269    OMIM disorders: --

    20/201 diseases for CD44 (see all 201):    About MalaCards
    superficial keratitis    spinal cord astrocytoma    lichen sclerosus    intraductal papilloma
    follicular mucinosis    thymic epithelial neoplasm    primary cutaneous anaplastic large cell lymphoma    gastrointestinal neuroendocrine tumor
    gastrointestinal lymphoma    nonpapillary renal cell carcinoma    gastric lymphoma    prostate small cell carcinoma
    female breast carcinoma    ganglioneuroblastoma    arteriosclerosis obliterans    gliomatosis cerebri
    colonic neoplasm    verrucous carcinoma    cardia cancer    malignant peripheral nerve sheath tumor

    14 diseases from the University of Copenhagen DISEASES database for CD44:
    Carcinoma     Breast cancer     Colorectal cancer     Leukemia
    Lymphoma     Prostate cancer     Arthritis     Pancreatic cancer
    Melanoma     Ovarian cancer     Lung cancer     Hypersensitivity reaction type II disease
    Malignant glioma     Kidney disease

    CD44 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for CD44 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 78.3 546 11005492 (8), 9772282 (5), 11582589 (5), 17912438 (4) (see all 99)
    tumors 73.6 1071 17912438 (8), 10200702 (8), 8579108 (7), 11839564 (7) (see all 99)
    carcinoma 64.7 229 8567994 (5), 12534600 (4), 9826464 (4), 10547541 (3) (see all 99)
    cancer 61.5 294 11832714 (6), 11313172 (4), 9090502 (3), 7518345 (3) (see all 99)
    primary tumor 57.2 38 14666731 (3), 8682582 (2), 17006832 (2), 12854146 (2) (see all 26)
    colon carcinoma 54.2 55 18234849 (4), 8678563 (4), 11431370 (3), 8858111 (3) (see all 29)
    colorectal carcinoma 53.2 64 12782013 (4), 7504563 (3), 9754757 (3), 11911305 (3) (see all 33)
    adenocarcinoma 52.7 98 7537174 (5), 8599448 (4), 15717748 (4), 8608952 (3) (see all 61)
    aggressiveness 52.1 31 7576964 (3), 10846530 (3), 10355528 (2), 11213839 (1) (see all 20)
    carcinoma squamous cell 50.2 72 17679465 (4), 19900133 (3), 9725567 (3), 8599448 (2) (see all 45)

    Genetic Association Database (GAD): CD44
    Human Genome Epidemiology (HuGE) Navigator: CD44 (24 documents)

    Export disorders for CD44 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD44 gene, integrated from 9 sources (see all 2179):
    (articles sorted by number of sources associating them with CD44)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase. (PubMed id 8352881)1, 2, 9 Tanabe K.K.... Saya H. (1993)
    2. Expression of CD44 is repressed in neuroblastoma cells. (PubMed id 1922057)1, 2, 9 Shtivelman E. and Bishop J.M. (1991)
    3. Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44. (PubMed id 10933060)1, 2, 9 Chiu R.K....Dougherty G.J. (1999)
    4. Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325. (PubMed id 9580567)1, 2, 9 Peck D. and Isacke C.M. (1998)
    5. CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. (PubMed id 1717145)1, 2, 9 Hofmann M....Guenthert U. (1991)
    6. Application of gene network analysis techniques ident ifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve . (PubMed id 20098615)1, 4 Wooten E.C....Huggins G.S. (2010)
    7. Unique SNP in CD44 intron 1 and its role in breast ca ncer development. (PubMed id 20530438)1, 4 Zhou J....Nagarkatti M. (2010)
    8. Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis. (PubMed id 20806065)1, 4 Ryckman K.K....Hennig B.J. (2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 960 HGNC: 1681 AceView: CD44 Ensembl:ENSG00000026508 euGenes: HUgn960
    ECgene: CD44 Kegg: 960 H-InvDB: CD44

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD44 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD44 Genetics and Cytogenetics in Oncology and Haematology
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=indian
    Wikipedia http://en.wikipedia.org/wiki/CD44

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD44 gene:
    Search GeneIP for patents involving CD44

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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