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Aliases for CD44 Gene

Aliases for CD44 Gene

  • CD44 Molecule (Indian Blood Group) 2 3
  • MDU2 3 4 6
  • MDU3 3 4 6
  • MIC4 3 4 6
  • Hematopoietic Cell E- And L-Selectin Ligand 2 3
  • GP90 Lymphocyte Homing/Adhesion Receptor 3 4
  • Chondroitin Sulfate Proteoglycan 8 2 3
  • Extracellular Matrix Receptor III 3 4
  • Heparan Sulfate Proteoglycan 3 4
  • Phagocytic Glycoprotein 1 3 4
  • Hyaluronate Receptor 3 4
  • Hermes Antigen 3 4
  • CD44 Antigen 3 4
  • ECMR-III 3 4
  • HUTCH-I 3 4
  • Epican 3 4
  • CDW44 3 4
  • LHR 3 4
  • IN 3 6
  • CD44 Antigen (Homing Function And Indian Blood Group System) 2
  • Homing Function And Indian Blood Group System 3
  • Cell Surface Glycoprotein CD44 3
  • Phagocytic Glycoprotein I 4
  • CSPG8 3
  • HCELL 3
  • PGP-1 4
  • PGP-I 4
  • MC56 3
  • Pgp1 3

External Ids for CD44 Gene

Previous Symbols for CD44 Gene

  • MIC4
  • MDU2
  • MDU3

Summaries for CD44 Gene

Entrez Gene Summary for CD44 Gene

  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD44 Gene

CD44 (CD44 Molecule (Indian Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include superficial keratitis and gastrointestinal lymphoma. Among its related pathways are Proteoglycans in cancer and Disease. GO annotations related to this gene include transmembrane signaling receptor activity and hyaluronic acid binding. An important paralog of this gene is LYVE1.

UniProtKB/Swiss-Prot for CD44 Gene

  • Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Gene Wiki entry for CD44 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD44 Gene

Genomics for CD44 Gene

Genomic Location for CD44 Gene

Start:
35,138,870 bp from pter
End:
35,232,402 bp from pter
Size:
93,533 bases
Orientation:
Plus strand

Genomic View for CD44 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD44 Gene

Regulatory Elements for CD44 Gene

Proteins for CD44 Gene

  • Protein details for CD44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16070-CD44_HUMAN
    Recommended name:
    CD44 antigen
    Protein Accession:
    P16070
    Secondary Accessions:
    • A5YRN9
    • B6EAT9
    • D3DR12
    • D3DR13
    • O95370
    • P22511
    • Q04858
    • Q13419
    • Q13957
    • Q13958
    • Q13959
    • Q13960
    • Q13961
    • Q13967
    • Q13968
    • Q13980
    • Q15861
    • Q16064
    • Q16065
    • Q16066
    • Q16208
    • Q16522
    • Q86T72
    • Q86Z27
    • Q8N694
    • Q92493
    • Q96J24
    • Q9H5A5
    • Q9UC28
    • Q9UC29
    • Q9UC30
    • Q9UCB0
    • Q9UJ36

    Protein attributes for CD44 Gene

    Size:
    742 amino acids
    Molecular mass:
    81538 Da
    Quaternary structure:
    • Interacts with PKN2. Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with UNC119.

    Three dimensional structures from OCA and Proteopedia for CD44 Gene

neXtProt entry for CD44 Gene

Proteomics data for CD44 Gene at MOPED

Post-translational modifications for CD44 Gene

  • N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
  • Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
  • Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn25, Asn57, Asn100, Asn110, Asn120, Thr174, Thr197, Ser199, Thr200, Thr318, Thr325, Ser330, Ser332, Asn350, Tyr412, Ser422, Thr423, Thr424, Thr426, Ser430, Thr433, Ser434, Ser458, Ser478, Thr480, Thr484, Thr489, Ser514, Thr515, Thr528, Thr529, Thr541, Asn548, Ser550, Ser553, Thr554, Thr555, Tyr560, Thr561, Ser562, Thr567, Ser570, Thr572, Thr577, Ser578, Thr581, Ser583, Asn599, Asn636, Thr637, and Thr638

No data available for DME Specific Peptides for CD44 Gene

Domains for CD44 Gene

Gene Families for CD44 Gene

HGNC:
  • CD :CD molecules
  • bloodgroup :Blood group antigens
  • CSPG :Proteoglycans / Cell surface : Other

UniProtKB/Swiss-Prot:

CD44_HUMAN
Domain:
  • The lectin-like LINK domain is responsible for hyaluronan binding.:
    • P16070
  • Contains 1 Link domain.:
    • P16070
genes like me logo Genes that share domains with CD44: view

Function for CD44 Gene

Molecular function for CD44 Gene

GENATLAS Biochemistry: cell differentiation antigen CD44 (Pgp-1),80-95kDa,identified by antibodies GRHL1,F10-44-2 (including MDU2,MDU3,MIC4 identified by monoclonal antibodies A1G3,13D8,F10.44),lymphocyte homing receptor,involved in extracellular matrix adhesion and in myeloid differentiation,expressed in small lymphocytic and mantle cell lymphoma,on leukemic blasts from most AML patients,and in invasive basal cell carcinomas
UniProtKB/Swiss-Prot Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Gene Ontology (GO) - Molecular Function for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004415 hyalurononglucosaminidase activity IDA 17170110
GO:0004888 transmembrane signaling receptor activity --
GO:0004896 contributes_to cytokine receptor activity IDA 17045821
GO:0005515 protein binding IPI 11207560
GO:0005518 collagen binding NAS 2471973
genes like me logo Genes that share ontologies with CD44: view
genes like me logo Genes that share phenotypes with CD44: view

Animal Models for CD44 Gene

MGI Knock Outs for CD44:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD44 Gene

Localization for CD44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD44 Gene

Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD44 Gene COMPARTMENTS Subcellular localization image for CD44 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
cytoskeleton 3
extracellular 3
nucleus 2
endoplasmic reticulum 1
endosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 1991450
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CD44: view

Pathways for CD44 Gene

genes like me logo Genes that share pathways with CD44: view

Gene Ontology (GO) - Biological Process for CD44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0002246 wound healing involved in inflammatory response IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007155 cell adhesion --
GO:0007160 cell-matrix adhesion NAS 1922057
genes like me logo Genes that share ontologies with CD44: view

Compounds for CD44 Gene

(1) HMDB Compounds for CD44 Gene

Compound Synonyms Cas Number PubMed IDs
Hyaluronic acid
  • hyaluronic acid
9004-61-9

(1) Drugbank Compounds for CD44 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Hyaluronan
  • Hyaluronate
9067-32-7 target

(98) Novoseek inferred chemical compound relationships for CD44 Gene

Compound -log(P) Hits PubMed IDs
hyaluronic acid 84 224
glycosaminoglycan 70.9 30
chondroitin sulfate 59.1 35
matrigel 52.9 10
heparan sulfate 47.5 29
genes like me logo Genes that share compounds with CD44: view

Transcripts for CD44 Gene

Unigene Clusters for CD44 Gene

CD44 molecule (Indian blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD44 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - -
SP10: - - - -
SP11: - - -
SP12: - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - -
SP14: - - - -
SP15: - - - -
SP16: - - - -
SP17: - - - -
SP18: - - - -
SP19:
SP20:
SP21:
SP22: -
SP23: - - - - - - - - - -
SP24:
SP25: - - - -
SP26: - - - -
SP27:
SP28:
SP29: - - - - - - - - - - - - - - -
SP30:
SP31: -
SP32:
SP33:

ExUns: 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d · 14e ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a ·
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8:
SP9: - - - - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - - - - - - -
SP16: - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - - - - - - -
SP19: - - - - -
SP20: - - - - - - - - - - - - -
SP21: - -
SP22:
SP23: - - - - - - - - - - - - - - - - - -
SP24:
SP25: - - - - - - - - - - - - - - - - - - - -
SP26: - - - - -
SP27: - - - - - - - - - - - - - - -
SP28:
SP29: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP30: - - -
SP31:
SP32:
SP33:

ExUns: 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b · 26c
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28: -
SP29: - -
SP30:
SP31:
SP32:
SP33: - - - - -

Relevant External Links for CD44 Gene

GeneLoc Exon Structure for
CD44
ECgene alternative splicing isoforms for
CD44

Expression for CD44 Gene

mRNA expression in normal human tissues for CD44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD44 Gene

This gene is overexpressed in Whole Blood (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD44 Gene

SOURCE GeneReport for Unigene cluster for CD44 Gene Hs.502328

mRNA Expression by UniProt/SwissProt for CD44 Gene

P16070-CD44_HUMAN
Tissue specificity: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells
genes like me logo Genes that share expressions with CD44: view

Orthologs for CD44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD44 36
  • 99.1 (n)
  • 98.52 (a)
CD44 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD44 36
  • 87.69 (n)
  • 88.08 (a)
CD44 37
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD44 36
  • 85.49 (n)
  • 84.57 (a)
CD44 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd44 36
  • 78.71 (n)
  • 70.24 (a)
Cd44 16
Cd44 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD44 37
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD44 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd44 36
  • 79.94 (n)
  • 71.33 (a)
chicken
(Gallus gallus)
Aves CD44 36
  • 66.41 (n)
  • 61.24 (a)
CD44 37
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD44 37
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd44 36
  • 52.68 (n)
  • 43.75 (a)
MGC75816 36
zebrafish
(Danio rerio)
Actinopterygii cd44a 37
  • 19 (a)
OneToMany
cd44b 37
  • 22 (a)
OneToMany
Species with no ortholog for CD44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD44 Gene

ENSEMBL:
Gene Tree for CD44 (if available)
TreeFam:
Gene Tree for CD44 (if available)

Paralogs for CD44 Gene

Paralogs for CD44 Gene

genes like me logo Genes that share paralogs with CD44: view

Variants for CD44 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD44 Gene

P16070-CD44_HUMAN
CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B), the most frequent allele, has Arg-46

Sequence variations from dbSNP and Humsavar for CD44 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8193 -- 35,229,771(+) CATTG(C/T)TTTCC utr-variant-3-prime
rs13347 -- 35,231,725(+) CTACA(C/T)GTCAT utr-variant-3-prime
rs102518 -- 35,163,747(-) GCTAA(C/T)ACCAT intron-variant
rs112762 other 35,171,082(+) ATACA(C/T)AATGA intron-variant
rs187115 -- 35,154,612(-) CATTG(A/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD44 Gene

Variant ID Type Subtype PubMed ID
dgv361e1 CNV Complex 17122850
nsv508623 CNV Loss 20534489
esv2744344 CNV Deletion 23290073
nsv39411 CNV Insertion 16902084
dgv1071n71 CNV Gain 21882294
dgv1072n71 CNV Gain 21882294

Relevant External Links for CD44 Gene

HapMap Linkage Disequilibrium report
CD44
Human Gene Mutation Database (HGMD)
CD44
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group

Disorders for CD44 Gene

(1) OMIM Diseases for CD44 Gene (107269)

(94) Novoseek inferred disease relationships for CD44 Gene

Disease -log(P) Hits PubMed IDs
metastasis 78.3 234
tumors 73.6 356
carcinoma 64.7 153
cancer 61.5 155
primary tumor 57.2 31

Relevant External Links for CD44

Genetic Association Database (GAD)
CD44
Human Genome Epidemiology (HuGE) Navigator
CD44
genes like me logo Genes that share disorders with CD44: view

No data available for UniProtKB/Swiss-Prot for CD44 Gene

Publications for CD44 Gene

  1. CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. (PMID: 1717145) Hofmann M. … Guenthert U. (Cancer Res. 1991) 3 4 23
  2. Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase. (PMID: 8352881) Tanabe K.K. … Saya H. (Mol. Carcinog. 1993) 3 4 23
  3. Expression of CD44 is repressed in neuroblastoma cells. (PMID: 1922057) Shtivelman E. … Bishop J.M. (Mol. Cell. Biol. 1991) 3 4 23
  4. Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325. (PMID: 9580567) Peck D. … Isacke C.M. (J. Cell Sci. 1998) 3 4 23
  5. Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44. (PMID: 10933060) Chiu R.K. … Dougherty G.J. (Neoplasia 1999) 3 4 23

Products for CD44 Gene

  • Addgene plasmids for CD44

Sources for CD44 Gene

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