CD40LG Gene
protein-coding GIFtS: 69
GCID: GC0XP135730
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|
CD40 ligand(Previous names: tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM...)
(Previous symbols: HIGM1, IMD3, TNFSF5)
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Aliases
for CD40LG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CD40 Ligand1 2 | | T-Cell Antigen Gp392 3 | | TNFSF51 2 3 5 | | TNF-Related Activation Protein2 3 | | CD40L1 2 3 | | IGM2 5 | | TRAP1 2 3 | | Tumor Necrosis Factor (Ligand) Superfamily, Member 5 (Hyper-IgM Syndrome)1 | | HIGM11 2 5 | | T-BAM2 | | CD1541 2 | | CD40 Antigen Ligand2 | | IMD31 2 | | T-B Cell-Activating Molecule2 | | Gp391 | | Tumor Necrosis Factor (Ligand) Superfamily Member 52 | | HCD40L1 | | CD154 Antigen3 | | CD40-L2 3 | | Tumor Necrosis Factor Ligand Superfamily Member 53 |
Export aliases for CD40LG gene to outside databasesPrevious GC identifers: GC0XP135456 GC0XP135558 GC0XP125001 |
Summaries
for CD40LG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CD40LG:
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and isassociated with hyper-IgM syndrome. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CD40L_HUMAN, P29965Function: Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence ofIL-4. Involved in immunoglobulin class switchingFunction: Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and anmatrix metalloproteinases (MMP) inhibitor-sensitive pathway
Gene Wiki entry for CD40LG (CD154)
|
Genomic Views
for CD40LG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CD40LG gene promoter:
TBP STAT1 AP-1 ATF-2 STAT1beta STAT1alpha TFIID c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CD40LG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD40LG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26 Ensembl cytogenetic band: Xq26.3 HGNC cytogenetic band: Xq26CD40LG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP135730: view genomic region
(about GC identifiers)
Start:
|
135,730,336 bp from pter |
End:
|
135,742,549 bp from pter |
Size:
|
12,214 bases |
Orientation:
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plus strand |
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Proteins
for CD40LG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CD40L_HUMAN, P29965 (See
protein sequence)Recommended Name: CD40 ligand Size: 261 amino acids; 29274 Da
Subunit: Homotrimer
Subcellular location: Cell membrane; Single-pass type II membrane protein
Subcellular location: CD40 ligand, soluble form: Secreted
4 PDB 3D structures from  and Proteopedia  for CD40LG:1ALY (3D)
1I9R (3D)
3LKJ (3D)
3QD6 (3D)
Explore the universe of human proteins at neXtProt for CD40LG: NX_P29965
Post-translational modifications:
The soluble form derives from the membrane form by proteolytic processing1
N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity toCD401
Not O-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P29965
CD40LG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000065.1
ENSEMBL proteins: ENSP00000359663 ENSP00000359662 Reactome Protein details: P29965
Human Recombinant Protein Products for CD40LG:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CD40LG for ontologies About GeneDecksing
CD40LG Antibody Products:
Assay Products for CD40LG: |
Protein
Domains /
Families
for CD40LG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CD40LG for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P29965ProtoNet protein and cluster: P29965 2 Blocks protein families: IPB003263 CD40 ligand/CD154 antigen signature IPB006052 Tumor Necrosis Factor
UniProtKB/Swiss-Prot: CD40L_HUMAN, P29965Similarity: Belongs to the tumor necrosis factor family |
Function
for CD40LG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CD40L_HUMAN, P29965Function: Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence ofIL-4. Involved in immunoglobulin class switchingFunction: Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and anmatrix metalloproteinases (MMP) inhibitor-sensitive pathway Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CD40LG for ontologies About GeneDecksing
Phenotypes:
13 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Cd40lg):
CD40LG for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for CD40LG: Cd40lgtm1Flv Cd40lgtm1Imx
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD40LG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD40LG
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CD40LG (NM_000074) | |  | Sino Biological Human cDNA Clone for CD40LG | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CD40LG | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD40LG |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD40LG |
|
Pathways & Interactions
for CD40LG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Allograft rejection | | | 2 | Immune System | | | 3 | Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway | | | 4 | Calcium signaling in the CD4+ TCR pathway | | | 5 | Id Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CD40LG
2  R&D Systems Pathways for CD40LG
1  GeneGo (Thomson Reuters) Pathway for CD40LG
5/6  BioSystems Pathways for CD40LG (see all 6)
3 
Reactome Pathways for CD40LG
5/12 
Kegg Pathways (Kegg details for CD40LG) (see all 12):
CD40LG for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD40LG
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/38 Interacting proteins for CD40LG (P299653 ENSP000003596634) via UniProtKB, MINT, STRING, and/or I2D (see all 38)About this table
Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table
CD40LG for ontologies About GeneDecksing
|
Drugs & Compounds
for CD40LG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CD40LG for compounds About GeneDecksing
 Browse Tocris compounds for CD40LG
1 HMDB Compound for CD40LG About this table
10/127 Novoseek chemical compound relationships for CD40LG gene (see all 127) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cardiolipin |
65.7 |
48 |
7699683 (2), 8862250 (2), 12209031 (2), 2117391 (1) (see all 35) |
| stresson |
55.8 |
1 |
11677993 (1) |
| fibrinogen |
54.7 |
108 |
15811120 (3), 12379582 (3), 11352081 (2), 18789071 (2) (see all 86) |
| ivig |
54.6 |
57 |
2209705 (4), 1932300 (3), 8633217 (3), 11188771 (2) (see all 29) |
| hu5c8 |
54.6 |
1 |
11740405 (1) |
| blys |
53.5 |
10 |
19421221 (3), 15188365 (1), 17567982 (1), 19258594 (1) (see all 7) |
| galalpha(1,3)gal |
53.1 |
2 |
15114098 (1), 9799716 (1) |
| sulfolipid i |
49.9 |
4 |
12354881 (2), 14715547 (1) |
| sandoglobulin |
48.6 |
2 |
1932300 (1) |
| rituximab |
48.5 |
31 |
12640069 (5), 19084309 (3), 18761748 (2), 15493038 (2) (see all 12) |
Search CenterWatch for drugs/clinical trials and news about CD40LG / CD40L
|
Transcripts
for CD40LG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CD40LG gene: NM_000074.2 Unigene Cluster for CD40LG: CD40 ligand Hs.592244 [show with all ESTs]Unigene Representative Sequence: BC0717542 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370629(uc010nse.1 uc004faa.3 uc010nsd.3) ENST00000370628
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD40LG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD40LG
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CD40LG (NM_000074) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CD40LG | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD40LG |
Additional cDNA sequence: AF529195.1 AK292637.1 AY197739.1 BC071754.1 BC074950.2 FN298241.1 L07414.1 X67878.1 X68550.1 X96710.1 Z15017.1 1 DOTS entry: DT.308261 15 AceView cDNA sequences: X67878 BC074950 BV207218 CD521613 BC071754 CD638712 L07414 CD642064 CD520208 Z15017 CD640741 NM_000074 X68550 CA432817 X96710
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CD40LG About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for CD40LG
|
Expression
for CD40LG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CD40LG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACCAAAAC
About this image
See CD40LG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD40LG
SOURCE GeneReport for Unigene cluster: Hs.592244
UniProtKB/Swiss-Prot: CD40L_HUMAN, P29965Tissue specificity: Specifically expressed on activated CD4+ T-lymphocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including CD40LG (see all 22):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD40LG
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD40LG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD40LG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD40LG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD40LG |
Orthologs
for CD40LG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CD40LG gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for CD40LG (if available)
TreeFam Gene Tree for CD40LG (if available) |
Paralogs
for CD40LG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CD40LG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CD40LG (135730336 - 135742549 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD40LG: --
Human Gene Mutation Database (HGMD): CD40LG
Locus Specific Mutation Databases (LSDB): CD40LG
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD40LG |
|
Disorders
/ Diseases
for CD40LG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CD40LG for disorders About GeneDecksing
OMIM gene information: 300386
OMIM disorders: 308230
UniProtKB/Swiss-Prot: CD40L_HUMAN, P29965
Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; alsoknown as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized byelevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an earlyage (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystiscarinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment withintravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence
20/362  diseases for CD40LG (see all 362): About MalaCardsafrican tick-bite fever pure red-cell aplasia guillain-barre syndrome st. louis encephalitis
erythema infectiosum monoclonal gammopathy of undetermined significance heparin-induced thrombocytopenia marginal zone b-cell lymphoma
epstein-barr virus hepatitis scrub typhus la crosse encephalitis dandy-walker syndrome
immune-complex glomerulonephritis chronic recurrent multifocal osteomyelitis immunodeficiency with hyper igm type 1 immunodeficiency with hyper igm
isolated growth hormone deficiency common variable immunodeficiency acquired von willebrand syndrome dengue hemorrhagic fever
9 diseases from the University of Copenhagen DISEASES database for CD40LG:Primary immunodeficiency disease Atherosclerosis Systemic lupus erythematosus Blood protein disease
Lymphoma Coronary heart disease Leukemia Myocardial infarction
Diabetes mellitus 10/95 Novoseek disease relationships for CD40LG gene (see all 95) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hyper-igm syndrome |
86 |
72 |
7907793 (4), 7679206 (4), 10559240 (2), 11038461 (2) (see all 37) |
| waldenstrom macroglobulinemia |
73.4 |
46 |
9762027 (2), 8678056 (2), 19362963 (2), 1656848 (1) (see all 36) |
| m syndrome |
70.8 |
3 |
7679801 (1), 17244160 (1), 8914765 (1) |
| lupus erythematosus systemic |
70.4 |
59 |
19232124 (2), 16393964 (2), 2383077 (2), 9462168 (2) (see all 45) |
| rheumatoid arthritis |
65.6 |
72 |
16489709 (3), 7777825 (2), 18521455 (2), 1718404 (2) (see all 60) |
| monoclonal gammopathy |
65.2 |
83 |
9845848 (4), 11160960 (4), 19720975 (3), 18708629 (3) (see all 51) |
| antiphospholipid syndrome |
64.4 |
16 |
8607123 (2), 8608682 (2), 1549196 (1), 9773961 (1) (see all 11) |
| common variable immunodeficiency |
64 |
12 |
11096255 (1), 7524537 (1), 16641210 (1), 2165880 (1) (see all 11) |
| iga deficiency |
63.9 |
18 |
1496540 (3), 8385798 (1), 15940551 (1), 2146585 (1) (see all 16) |
| autoimmune diseases |
62.7 |
50 |
11905841 (3), 15571927 (2), 19151119 (2), 8514202 (2) (see all 35) |
GeneTests: CD40LG
X-Linked Hyper IgM Syndrome
Genetic Association Database (GAD): CD40LG
Human Genome Epidemiology (HuGE) Navigator: CD40LG (26 documents)
Export disorders for CD40LG gene to outside databases
|
Publications
for CD40LG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CD40LG gene, integrated from 9 sources (see all 2502):
(articles sorted by number of sources associating them with CD40LG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. (PubMed id 7678782)1, 2, 3, 9 Aruffo A....Neubauer M. (1993)
- The role of polar interactions in the molecular recognition of CD40L with its receptor CD40. (PubMed id 9605317)1, 2, 9 Singh J.... Thomas D. (1998)
- Immune response gene polymorphisms in renal transplant recipients. (PubMed id 16378074)1, 4, 9 Dmitrienko S....Keown P.A. (2005)
- The dinucleotide repeat polymorphism in the 3'UTR of the CD154 gene has a functional role on protein expression and is associated with systemic lupus erythematosus. (PubMed id 14962968)1, 4, 9 Citores M.J....Perez-Aciego P. (2004)
- Signaling through CD40 rescues IgE but not IgG or IgA secretion in X- linked immunodeficiency with hyper-IgM. (PubMed id 7532185)1, 2, 9 Saiki O.... Matsuda I. (1995)
- Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. (PubMed id 7679206)1, 2, 9 Korthaeuer U....Kroczek R.A. (1993)
- Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production. (PubMed id 7678552)1, 2, 9 Gauchat J.-F.... Bonnefoy J.-Y. (1993)
- CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. (PubMed id 7679801)1, 2, 9 Allen R.C.... Spriggs M.K. (1993)
- Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells. (PubMed id 11676606)1, 2, 9 Khandekar S.S....Fishman-Lobell J. (2001)
- Cloning of TRAP, a ligand for CD40 on human T cells. (PubMed id 1280226)1, 2, 9 Graf D.... Kroczek R.A. (1992)
|
External Searches for CD40LG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CD40LG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CD40LG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD40LG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CD40LG | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for CD40LG | Genetics and Cytogenetics in Oncology and Haematology | | CD40Lbase | http://bioinf.uta.fi/CD40Lbase/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD40LG |
|
| | |
About This Section
| Patent Information for CD40LG gene:
Search GeneIP for patents involving CD40LG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CD40LG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for CD40LG | | OriGene shRNA RFP for CD40LG | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD40LG | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD40LG | | | OriGene Protein Over-expression Lysate for CD40LG | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CD40LG | | OriGene 3'-UTR Clone for CD40LG | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD40LG | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD40LG | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CD40LG | | OriGene Custom Protein Services for CD40LG | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD40LG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD40LG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD40LG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD40LG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD40LG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD40LG |
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| | | | Search Tocris compounds for CD40LG |
| |  |  |  |  | | | | | | Recombinant Protein for CD40LG |
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 | | | CD40LG Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD40LG |
|  |  |  |  | | | | ThermoFisher Antibodies for CD40LG |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD40LG |
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