Aliases for CD40LG Gene
- CD40 Ligand 2 3 5
- TNF-Related Activation Protein 2 3 4
- Tumor Necrosis Factor (Ligand) Superfamily Member 5 2 3
- T-B Cell-Activating Molecule 2 3
- CD40 Antigen Ligand 2 3
- T-Cell Antigen Gp39 3 4
- TNFSF5 3 4
- CD40-L 3 4
- CD40L 3 4
- TRAP 3 4
- Tumor Necrosis Factor (Ligand) Superfamily, Member 5 (Hyper-IgM Syndrome) 2
External Ids for CD40LG Gene
Previous HGNC Symbols for CD40LG Gene
Previous GeneCards Identifiers for CD40LG Gene
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD40LG Gene
CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Cd40 Ligand Deficiency. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity and CD40 receptor binding.
UniProtKB/Swiss-Prot for CD40LG Gene
Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.