Aliases for CD40 Gene
External Ids for CD40 Gene
Previous Symbols for CD40 Gene
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
GeneCards Summary for CD40 Gene
CD40 (CD40 Molecule, TNF Receptor Superfamily Member 5) is a Protein Coding gene. Diseases associated with CD40 include chromosome 20q deletion and blood protein disease. Among its related pathways are Class I MHC mediated antigen processing and presentation and NF-KappaB Family Pathway. GO annotations related to this gene include signal transducer activity and receptor activity. An important paralog of this gene is TNFRSF14.
UniProtKB/Swiss-Prot for CD40 Gene
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion