Aliases for CD40 Gene
Aliases for CD40 Gene
External Ids for CD40 Gene
- HGNC: 11919
- Entrez Gene: 958
- Ensembl: ENSG00000101017
- OMIM: 109535
- UniProtKB: P25942
Previous HGNC Symbols for CD40 Gene
- TNFRSF5
Previous GeneCards Identifiers for CD40 Gene
- GC20P044181
- GC20P044746
- GC20P041488
Summaries for CD40 Gene
-
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
GeneCards Summary for CD40 Gene
CD40 (CD40 Molecule) is a Protein Coding gene. Diseases associated with CD40 include Immunodeficiency With Hyper-Igm, Type 3 and Acute Myocarditis. Among its related pathways are TRAF Pathway and Allograft rejection. GO annotations related to this gene include enzyme binding and receptor activity. An important paralog of this gene is LTBR.
UniProtKB/Swiss-Prot for CD40 Gene
-
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD40 Gene
Genomics for CD40 Gene
Regulatory Elements for CD40 Gene
Enhancers for CD40 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CD40 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CD40 gene promoter:
Regulatory Element Products
Genomic Location for CD40 Gene
- Chromosome:
- 20
- Start:
- 46,118,250 bp from pter
- End:
- 46,129,863 bp from pter
- Size:
- 11,614 bases
- Orientation:
- Plus strand
Genomic View for CD40 Gene
Genes around CD40 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC
CD40 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD40 Gene
Proteins for CD40 Gene
-
Protein details for CD40 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25942-TNR5_HUMAN
- Recommended name:
- Tumor necrosis factor receptor superfamily member 5
- Protein Accession:
- P25942
- E1P5S9
- Q53GN5
- Q5JY15
- Q5U007
- Q7M4Q8
- Q86YK5
- Q9BYU0
Protein attributes for CD40 Gene
- Size:
- 277 amino acids
- Molecular mass:
- 30619 Da
- Quaternary structure:
-
- Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation.
Three dimensional structures from OCA and Proteopedia for CD40 Gene
Protein Expression for CD40 Gene
Post-translational modifications for CD40 Gene
Other Protein References for CD40 Gene
Antibody Products
- R&D Systems Antibodies for CD40 (CD40/TNFRSF5)
-
Custom Antibody ServicesOriGene Antibodies for CD40
- AM03135AF-N
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- UM870075
- UM800075
- CF807687
- TA807687
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- TA807683
- CF807682
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- TA807575
- CF807574
- TA807574
- CF807573
- TA807573
- CF807572
- TA807572
- CF807571
- TA807571
- CF807569
- TA807569
- TA353698
- TA352575
- TA351052
- TA346282
- TA346281
- TA320279
- TA320278
- TA318864
- TA313580
- TA311665
- SM1102RT
- SM1102R
- SM1102PT
- SM1102P
- SM1102FT
- SM1102F
- BM2542
- AP33488PU-N
- AP31189PU-N
- AP23319PU-N
- AP15442PU-S
- AP15442PU-N
- AP15442PU-M
- AP06445PU-N
- AM32379PU-N
- AM31223RP-N
- AM31223PU-N
- AM31223FC-N
- AM31223BT-N
- AM31223AF-N
- Novus Biologicals Antibodies for CD40
-
Abcam antibodies for CD40
-
Cloud-Clone Corp. Antibodies for CD40
- Invitrogen Antibodies for CD40
- antibodies-online Antibodies for CD40: See all 779
- GeneTex CD40 antibody for CD40
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD40
Protein Products
- R&D Systems Proteins and Enzymes for CD40 (CD40/TNFRSF5)
- Enzo Life Sciences proteins for CD40
- Search Origene for MassSpec and Protein Over-expression Lysates for CD40
- Origene Custom Protein Services for CD40
- Sino Biological Recombinant Proteins for CD40
- Sino Biological Cell Lysates for CD40
- ProSpec Recombinant Proteins for CD40
-
Cloud-Clone Corp. Proteins for CD40
- antibodies-online Proteins for CD40: See all 49
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CD40
-
Abcam proteins for CD40
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CD40
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for CD40 (CD40/TNFRSF5)
- Enzo Life Sciences assays for CD40
- eBioscience Human sCD40 Platinum ELISA 10 x 96 tests for CD40
- antibodies-online Kits for CD40: See all 56
-
Abcam assays for CD40
No data available for DME Specific Peptides for CD40 Gene
Domains & Families for CD40 Gene
Gene Families for CD40 Gene
Protein Domains for CD40 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD40 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD40 Gene
Function for CD40 Gene
Molecular function for CD40 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003823 | antigen binding | IEA | -- |
| GO:0004871 | signal transducer activity | TAS | 9671306 |
| GO:0004872 | receptor activity | IEA,TAS | 10092834 |
| GO:0005031 | tumor necrosis factor-activated receptor activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 7527023 |
Phenotypes for CD40 Gene
- MGI mutant phenotypes for CD40:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for CD40:
Animal Models for CD40 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD40
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CD40 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD40 gene
- Search ViGene Biosciences for CD40
CRISPR Products
-
OriGene CRISPR knockouts for CD40
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD40
- GenScript: Design CRISPR guide RNA sequences for CD40
miRNA for CD40 Gene
- miRTarBase miRNAs that target CD40
miRNA Products
- Search ViGene Biosciences for CD40
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CD40
- Browse OriGene Inhibitory RNA Products For CD40
-
ViGene Biosciences ready-to-package AAV shRNAs for CD40 gene
Clone Products
- Sino Biological Human cDNA Clone for CD40
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CD40
- VectorBuilder custom plasmid, inducible vectors for CD40
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD40
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CD40 (CD40/TNFRSF5)
Cell Line Products
-
Horizon Cell Lines for CD40
-
ViGene Biosciences adenoviral particle packaged cDNA for CD40 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD40 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD40 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD40 Gene
Localization for CD40 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD40 Gene
- Isoform I: Cell membrane; Single-pass type I membrane protein.
- Isoform II: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 3 |
| nucleus | 2 |
| lysosome | 2 |
| endosome | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 10748139 |
Pathways & Interactions for CD40 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Allograft rejection |
.44
|
|
| 2 | PEDF Induced Signaling |
.47
|
|
| 3 | Toll-like Receptor Signaling Pathway | ||
| 4 | Akt Signaling |
.60
.60
|
|
| 5 | 4-1BB Pathway |
.54
|
|
Pathways by source for CD40 Gene
1 Sino Biological pathway for CD40 Gene
6 BioSystems pathways for CD40 Gene
6 Reactome pathways for CD40 Gene
16 KEGG pathways for CD40 Gene
1 GeneGo (Thomson Reuters) pathway for CD40 Gene
5 R&D Systems pathways for CD40 Gene
15 Qiagen pathways for CD40 Gene
Interacting Proteins for CD40 Gene
Selected Interacting proteins:
ENSP00000361359
P25942-TNR5_HUMAN
for CD40 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001934 | positive regulation of protein phosphorylation | IMP | 21410936 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | IEA | -- |
| GO:0006461 | protein complex assembly | TAS | 10748139 |
| GO:0006874 | cellular calcium ion homeostasis | IMP | 21410936 |
Drugs & Compounds for CD40 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| rituximab | Approved | Pharma | Therapeutic Antibodies | 1692 | ||
| Simvastatin | Approved | Pharma | Competitive, Inhibitor | HMG-CoA reductase inhibitor | 519 | |
| nivolumab | Approved | Pharma | Therapeutic Antibodies, Immunotherapies | 424 | ||
| CD40 ligand | Pharma | 0 | ||||
| Alkylating Agents | Pharma | 4827 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CD40 Gene
mRNA/cDNA for CD40 Gene
- (10) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (119) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CD40 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CD40
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD40
- GenScript: Design CRISPR guide RNA sequences for CD40
miRNA Products
- Search ViGene Biosciences for CD40
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CD40
- Browse OriGene Inhibitory RNA Products For CD40
-
ViGene Biosciences ready-to-package AAV shRNAs for CD40 gene
Clone Products
- Sino Biological Human cDNA Clone for CD40
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CD40
- VectorBuilder custom plasmid, inducible vectors for CD40
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD40
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for CD40 (CD40/TNFRSF5)
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||
| SP4: | - |
Expression for CD40 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Large Pre B-Cells Hematopoietic Bone Marrow
- Eosinophils Peripheral Blood
- Mature B-Cells Peripheral Blood
- Macrophages Peripheral Blood
-
Dermis (Integumentary System)
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Bone (Muscoskeletal System)
This gene is overexpressed in Peripheral blood mononuclear cells (20.7), Breast (10.9), Platelet (10.2), and Gallbladder (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD40 Gene
NURSA nuclear receptor signaling pathways regulating expression of CD40 Gene:
CD40SOURCE GeneReport for Unigene cluster for CD40 Gene:
Hs.472860mRNA Expression by UniProt/SwissProt for CD40 Gene:
P25942-TNR5_HUMAN
Tissue specificity:
B-cells and in primary carcinomas.
Evidence on tissue expression from TISSUES for CD40 Gene
- Blood(4.8)
- Kidney(4.4)
- Lymph node(4)
- Spleen(4)
- Bone marrow(2.8)
- Skin(2.7)
- Lung(2.6)
- Intestine(2.5)
- Heart(2.4)
- Liver(2.2)
- Nervous system(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CD40 Gene
Germ Layers:
- mesoderm
Systems:
- immune
- lymphatic
Organs:
General:
- blood
- bone marrow
- lymph node
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CD40
-
OriGene qPCR primer pairs and template standards for CD40
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CD40 Gene
Orthologs for CD40 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CD40 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CD40 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CD40 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cd40 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cd40 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CD40 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CD40 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CD40 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cd40 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cd40 35 |
|
ManyToMany |
- Species where no ortholog for CD40 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CD40 Gene
Variants for CD40 Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs28931586 | Pathogenic, Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843] | 46,122,349(+) | AATAC(C/T)GCGAC | nc-transcript-variant, reference, missense | |
| rs750234130 | Bladder carcinoma cell line Hu549 | 46,121,871(+) | TAAAC(A/G)GTCAG | nc-transcript-variant, reference, missense | |
| VAR_039301 | Bladder carcinoma cell line Hu549 | ||||
| VAR_039303 | Bladder carcinoma cell line Hu549 | ||||
| VAR_077569 | Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843] |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758796 | CNV | loss | 17122850 |
| nsv1057686 | CNV | loss | 25217958 |
| nsv1138961 | CNV | deletion | 24896259 |
| nsv586135 | CNV | loss | 21841781 |
| nsv833993 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.02;
20.88% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CD40 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD40 Gene
Disorders for CD40 Gene
(41) MalaCards diseases for CD40 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency with hyper-igm, type 3 |
|
|
| acute myocarditis |
|
|
| cd40 ligand deficiency |
|
|
| immunodeficiency, x-linked, with hyper-igm |
|
|
| myocarditis |
|
|
Search CD40 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TNR5_HUMAN- Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. {ECO:0000269 PubMed:11675497, ECO:0000269 PubMed:26545377}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CD40
No data available for Genatlas for CD40 Gene
Publications for CD40 Gene
- Individual and epistatic effects of genetic polymorphisms of B-cell co-stimulatory molecules on susceptibility to pemphigus foliaceus. (PMID: 19421221) Malheiros D. … Petzl-Erler M.L. (Genes Immun. 2009) 3 22 46 64
- [Association between inflammatory cytokine CD40 gene polymorphism and risk of acute coronary syndrome]. (PMID: 19099972) Tian C.X. … Huang C.X. (Zhonghua Xin Xue Guan Bing Za Zhi 2008) 3 22 46 64
- Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE. (PMID: 17255560) Park J.H. … Shin H.D. (Am. J. Respir. Crit. Care Med. 2007) 3 22 46 64
- CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. (PMID: 9718306) Pullen S.S. … Kehry M.R. (Biochemistry 1998) 3 4 22 64
- A genome-wide association study identifies three new risk loci for Kawasaki disease. (PMID: 22446962) Onouchi Y. … . (Nat. Genet. 2012) 3 46 64
Products for CD40 Gene
- R&D Systems Antibodies for CD40 (CD40/TNFRSF5)
- R&D Systems Proteins and Enzymes for CD40 (CD40/TNFRSF5)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CD40 (CD40/TNFRSF5)
- R&D Systems cDNA Clones for CD40 (CD40/TNFRSF5)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CD40
- AM03135AF-N
- AM03135FC-N
- AM03135RP-N
- AM05671PU-N
- AM06355SU-N
- AM08347PU-N
- AM31223AF-N
- AM31223BT-N
- AM31223FC-N
- AM31223PU-N
- AM31223RP-N
- AM32379PU-N
- AP06445PU-N
- AP15442PU-M
- AP15442PU-N
- AP15442PU-S
- AP23319PU-N
- AP31189PU-N
- AP33488PU-N
- BM2542
- SM1102F
- SM1102FT
- SM1102P
- SM1102PT
- SM1102R
- SM1102RT
- TA311665
- TA313580
- TA318864
- TA320278
- TA320279
- TA346281
- TA346282
- TA351052
- TA352575
- TA353698
- TA807569
- CF807569
- TA807571
- CF807571
- TA807572
- CF807572
- TA807573
- CF807573
- TA807574
- CF807574
- TA807575
- CF807575
- TA807682
- CF807682
- TA807683
- CF807683
- TA807686
- CF807686
- TA807687
- CF807687
- UM800075
- UM870075
- Custom Assay ServicesOriGene ELISA Kits for CD40
- Search Origene for MassSpec and Protein Over-expression Lysates for CD40
- Origene Custom Protein Services for CD40
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CD40
- Browse OriGene Inhibitory RNA Products For CD40
- OriGene qPCR primer pairs and template standards for CD40
- OriGene qPCR primer pairs for CD40
- OriGene CRISPR knockouts for CD40
- OriGene ORF clones in human for CD40
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD40
- GenScript: Next-day shipping cDNA ORF clone for CD40 in any vector
- GenScript Purified and Recombinant Proteins for CD40
- GenScript Custom Purified and Recombinant Proteins Services for CD40
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- GenScript: Design CRISPR guide RNA sequences for CD40
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Human cDNA Clone for CD40
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- Sino Biological Cell Lysates for CD40
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Enzo Life Sciences proteins for CD40
- Enzo Life Sciences assays for CD40
- Browse drugs & compounds from Enzo Life Sciences
- Search Enzo Life Sciences for proteins, assays, substrates, inhibitors & antibodies
- Novus Biologicals Antibodies for CD40
- Novus Biologicals proteins and lysates for CD40
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CD40
- Abcam proteins for CD40
- Abcam assays for CD40
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for CD40
- Cloud-Clone Corp. Antibodies for CD40
- Cloud-Clone Corp. Proteins for CD40
- Browse Assay Kits at Cloud-Clone Corp.
- Addgene plasmids for CD40
- antibodies-online Antibodies for CD40: See all 779
- antibodies-online Kits for CD40: See all 56
- antibodies-online Proteins for CD40: See all 49
- Search antibodies-online for peptides
- GeneTex CD40 antibody for CD40
- Search GeneTex for Proteins for CD40
- ViGene Biosciences adenoviral particle packaged cDNA for CD40 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD40 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD40 gene
- Search ViGene Biosciences for CD40
- Santa Cruz Biotechnology (SCBT) Antibodies for CD40
- Search Santa Cruz Biotechnology (SCBT) for CD40 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD40
- Horizon Cell Lines for CD40
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD40
- VectorBuilder custom plasmid, inducible vectors for CD40
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD40
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CD40 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer