Aliases for CD40 Gene
Aliases for CD40 Gene
External Ids for CD40 Gene
- HGNC: 11919
- Entrez Gene: 958
- Ensembl: ENSG00000101017
- OMIM: 109535
- UniProtKB: P25942
Previous HGNC Symbols for CD40 Gene
- TNFRSF5
Previous GeneCards Identifiers for CD40 Gene
- GC20P044181
- GC20P044746
- GC20P041488
Summaries for CD40 Gene
-
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
GeneCards Summary for CD40 Gene
CD40 (CD40 Molecule) is a Protein Coding gene. Diseases associated with CD40 include Immunodeficiency With Hyper-Igm, Type 3 and Cd40 Ligand Deficiency. Among its related pathways are NLR Proteins and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include enzyme binding and receptor activity. An important paralog of this gene is TNFRSF11A.
UniProtKB/Swiss-Prot for CD40 Gene
-
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Additional gene information for CD40 Gene
- Monarch Initiative
- Search for CD40 at DataMed
- Search for CD40 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD40 Gene
Genomics for CD40 Gene
GeneHancer (GH) Regulatory Elements for CD40 Gene
Regulatory Element Products
Genomic Locations for CD40 Gene
- chr20:46,118,250-46,129,863
- (GRCh38/hg38)
- Size:
- 11,614 bases
- Orientation:
- Plus strand
- chr20:44,746,906-44,758,502
- (GRCh37/hg19)
Genomic View for CD40 Gene
- Cytogenetic band:
-
- 20q13.12 by Ensembl
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC


RefSeq DNA sequence for CD40 Gene
Proteins for CD40 Gene
-
Protein details for CD40 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25942-TNR5_HUMAN
- Recommended name:
- Tumor necrosis factor receptor superfamily member 5
- Protein Accession:
- P25942
- E1P5S9
- Q53GN5
- Q5JY15
- Q5U007
- Q7M4Q8
- Q86YK5
- Q9BYU0
Protein attributes for CD40 Gene
- Size:
- 277 amino acids
- Molecular mass:
- 30619 Da
- Quaternary structure:
-
- Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation.
Three dimensional structures from OCA and Proteopedia for CD40 Gene
Protein Expression for CD40 Gene
Post-translational modifications for CD40 Gene
- Glycosylation at posLast=153153 and Asn180
Other Protein References for CD40 Gene
Antibody Products
- R&D Systems Antibodies for CD40 (CD40/TNFRSF5)
- Cell Signaling Technology (CST) Antibodies for CD40 (CD40)
-
Custom Antibody ServicesOriGene Antibodies for CD40
- AM03135AF-N
- UM870075
- UM800075
- CF807687
- TA807687
- CF807686
- TA807686
- CF807683
- TA807683
- CF807682
- TA807682
- CF807575
- TA807575
- CF807574
- TA807574
- CF807573
- TA807573
- CF807572
- TA807572
- CF807571
- TA807571
- CF807569
- TA807569
- TA353698
- TA351052
- TA346282
- TA346281
- TA320279
- TA320278
- TA318864
- TA311665
- SM1102RT
- SM1102R
- SM1102PT
- SM1102P
- SM1102FT
- SM1102F
- BM2542
- AP33488PU-N
- AP31189PU-N
- AP23319PU-N
- AP06445PU-N
- AM31223RP-N
- AM31223PU-N
- AM31223FC-N
- AM31223BT-N
- AM31223AF-N
- AM08347PU-N
- AM06355SU-N
- AM05671PU-N
- AM03135RP-N
- AM03135FC-N
- Novus Biologicals Antibodies for CD40
-
Abcam antibodies for CD40
-
Cloud-Clone Corp. Antibodies for CD40
- Invitrogen Antibodies for CD40
- antibodies-online: Search results for 921 available CD40 Antibodies ranked by validation data
- Compare Top CD40 Antibodies
-
Recommended
- 1 IHC (p) Antibody (anti-rat)
- 2 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 14 FACS Antibodies (anti-rat)
- 34 WB Antibodies (anti-rat)
- 1 IFA Antibody (anti-human)
- 1 ISt Antibody (anti-human)
- 1 CC Antibody (anti-human)
- 6 ICC Antibodies (anti-human)
- 8 ICFC Antibodies (anti-human)
- 8 IF/ICC Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 20 IHC (fro) Antibodies (anti-human)
- 20 IF Antibodies (anti-human)
- 23 IP Antibodies (anti-human)
- 34 IHC (p) Antibodies (anti-human)
- 44 IHC Antibodies (anti-human)
- 171 FACS Antibodies (anti-human)
- 230 WB Antibodies (anti-human)
- 1 in vitro Antibody (anti-mouse)
- 1 IHC (zinc) Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 2 ELISPOT (Capture) Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 10 ICFC Antibodies (anti-mouse)
- 12 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 26 IHC (fro) Antibodies (anti-mouse)
- 41 IP Antibodies (anti-mouse)
- 59 WB Antibodies (anti-mouse)
- 122 FACS Antibodies (anti-mouse)
- GeneTex CD40 antibody for CD40
-
CrownBio Antibodies for CD40
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD40
- Sino Biological Antibodies for CD40
Protein Products
- R&D Systems Proteins and Enzymes for CD40 (CD40/TNFRSF5)
- Search Origene for MassSpec and Protein Over-expression Lysates for CD40
- Origene Custom Protein Services for CD40
- Sino Biological Recombinant Proteins for CD40
- Sino Biological Cell Lysates for CD40
- ProSpec Recombinant Proteins for CD40
-
Cloud-Clone Corp. Proteins for CD40
- Search GeneTex for Proteins for CD40
-
ProSci Proteins for CD40
- "CD40 molecule, TNF receptor superfamily member 5" [96-086]
- "CD40 molecule, TNF receptor superfamily member 5" [96-089]
- Tumor necrosis factor receptor superfamily member 5 [96-982]
- Tumor necrosis factor receptor superfamily member 5 [96-983]
- tumor necrosis factor receptor superfamily member 5 precursor [97-060]
- tumor necrosis factor receptor superfamily member 5 precursor [97-061]
- CD40 molecule [90-394]
- CD40 molecule [91-296]
- CD40 molecule [91-887]
- "CD40 molecule, TNF receptor superfamily member 5" [90-269]
- [96-801]
- [96-800]
-
Abcam proteins for CD40
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for CD40
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for CD40 (CD40/TNFRSF5)
-
Abcam assays for CD40
- Sino Biological Assays for CD40
No data available for DME Specific Peptides for CD40 Gene
Domains & Families for CD40 Gene
Gene Families for CD40 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CD40 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD40 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD40 Gene
Function for CD40 Gene
Molecular function for CD40 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Phenotypes From GWAS Catalog for CD40 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003823 | antigen binding | IEA | -- |
GO:0004871 | signal transducer activity | TAS | 9671306 |
GO:0004872 | receptor activity | TAS,IEA | 10092834 |
GO:0005031 | tumor necrosis factor-activated receptor activity | IBA | -- |
GO:0005515 | protein binding | IPI | 7527023 |
Phenotypes for CD40 Gene
- MGI mutant phenotypes for CD40:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for CD40:
Animal Models for CD40 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD40
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CD40 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD40 gene
- Search ViGene Biosciences for CD40
CRISPR Products
-
OriGene CRISPR knockouts for CD40
- genomics-online: gRNA clones - Search results for 161 available CD40 gene related products
- Overview of 161 available CD40 gene related products
- Applied Biological Materials CRISPR for CD40
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD40
- GenScript: Design CRISPR guide RNA sequences for CD40
miRNA for CD40 Gene
- miRTarBase miRNAs that target CD40
miRNA Products
- Search ViGene Biosciences for CD40
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CD40
- Browse OriGene Inhibitory RNA Products For CD40
- genomics-online: shRNA clones - Search results for 161 available CD40 gene related products
- Overview of 161 available CD40 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CD40 gene
Clone Products
- Sino Biological Human cDNA Clone for CD40
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD40
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD40
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD40
- Applied Biological Materials Clones for CD40
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD40 (CD40/TNFRSF5)
Cell Line Products
-
Horizon Cell Lines for CD40
-
ViGene Biosciences adenoviral particle packaged cDNA for CD40 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD40 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD40 gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD40 Gene
Localization for CD40 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD40 Gene
- Isoform I: Cell membrane; Single-pass type I membrane protein.
- Isoform II: Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | ISS,TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 10748139 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD40 Gene
Pathways & Interactions for CD40 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Allograft rejection |
.44
|
|
2 | PEDF Induced Signaling |
.47
|
|
3 | Akt Signaling |
.60
.60
|
|
4 | Toll-like receptor signaling pathway | ||
5 | 4-1BB Pathway |
.54
|
Pathways by source for CD40 Gene
1 Sino Biological pathway for CD40 Gene
5 BioSystems pathways for CD40 Gene
6 Reactome pathways for CD40 Gene
16 KEGG pathways for CD40 Gene
1 GeneGo (Thomson Reuters) pathway for CD40 Gene
3 R&D Systems pathways for CD40 Gene
15 Qiagen pathways for CD40 Gene
Interacting Proteins for CD40 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001934 | positive regulation of protein phosphorylation | IMP | 21410936 |
GO:0002376 | immune system process | IEA | -- |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | IEA | -- |
GO:0006461 | protein complex assembly | TAS | 10748139 |
GO:0006874 | cellular calcium ion homeostasis | IMP | 21410936 |
Drugs & Compounds for CD40 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
rituximab | Approved | Pharma | Therapeutic Antibodies | 1808 | ||
Simvastatin | Approved | Pharma | Competitive, Inhibitor | HMG-CoA reductase inhibitor | 537 | |
nivolumab | Approved | Pharma | Therapeutic Antibodies, Immunotherapies | 604 | ||
Dacetuzumab | Investigational | Pharma | Target, antibody | 0 | ||
CD40 ligand | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for CD40 Gene
mRNA/cDNA for CD40 Gene
- (10) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (119) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CD40 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CD40
- genomics-online: gRNA clones - Search results for 161 available CD40 gene related products
- Overview of 161 available CD40 gene related products
- Applied Biological Materials CRISPR for CD40
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD40
- GenScript: Design CRISPR guide RNA sequences for CD40
miRNA Products
- Search ViGene Biosciences for CD40
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CD40
- Browse OriGene Inhibitory RNA Products For CD40
- genomics-online: shRNA clones - Search results for 161 available CD40 gene related products
- Overview of 161 available CD40 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CD40 gene
Clone Products
- Sino Biological Human cDNA Clone for CD40
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD40
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD40
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD40
- Applied Biological Materials Clones for CD40
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD40 (CD40/TNFRSF5)
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||
SP4: | - |
Expression for CD40 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Large Pre B-Cells Hematopoietic Bone Marrow
- Eosinophils Peripheral Blood
- Mature B-Cells Peripheral Blood
- Macrophages Peripheral Blood
-
Dermis (Integumentary System)
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Bone (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD40 Gene
NURSA nuclear receptor signaling pathways regulating expression of CD40 Gene:
CD40SOURCE GeneReport for Unigene cluster for CD40 Gene:
Hs.472860mRNA Expression by UniProt/SwissProt for CD40 Gene:
P25942-TNR5_HUMANEvidence on tissue expression from TISSUES for CD40 Gene
- Blood(4.8)
- Kidney(4.4)
- Lymph node(4)
- Spleen(4)
- Bone marrow(2.8)
- Skin(2.7)
- Lung(2.6)
- Intestine(2.5)
- Heart(2.4)
- Liver(2.2)
- Thyroid gland(2)
- Nervous system(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CD40 Gene
- mesoderm
- immune
- lymphatic
- blood
- bone marrow
- lymph node
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CD40
-
OriGene qPCR primer pairs and template standards for CD40
- genomics-online: primer clones - Search results for 161 available CD40 gene related products
- Overview of 161 available CD40 gene related products
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CD40 Gene
Orthologs for CD40 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CD40 33 |
|
||
dog (Canis familiaris) |
Mammalia | CD40 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | CD40 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Cd40 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Cd40 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | CD40 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | CD40 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | CD40 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | cd40 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | cd40 34 |
|
ManyToMany |
- Species where no ortholog for CD40 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CD40 Gene
Variants for CD40 Gene
SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11086998 | likely-benign, benign, Immunodeficiency with Hyper-IgM, not specified | 46,128,885(+) | C/G/T | 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant, synonymous_variant | |
rs11569300 | likely-benign, Immunodeficiency with Hyper-IgM | 46,118,275(+) | T/ | 5_prime_UTR_variant, non_coding_transcript_variant | |
rs11569301 | likely-benign, Immunodeficiency with Hyper-IgM | 46,118,303(+) | C/G/T | 5_prime_UTR_variant, non_coding_transcript_variant | |
rs11569321 | likely-benign, Immunodeficiency with Hyper-IgM | 46,122,724(+) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs11569343 | likely-benign, Immunodeficiency with Hyper-IgM | 46,129,175(+) | C/G | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758796 | CNV | loss | 17122850 |
nsv1057686 | CNV | loss | 25217958 |
nsv1138961 | CNV | deletion | 24896259 |
nsv586135 | CNV | loss | 21841781 |
nsv833993 | CNV | gain | 17160897 |
Additional Variant Information for CD40 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD40 Gene
Disorders for CD40 Gene

(45) MalaCards diseases for CD40 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency with hyper-igm, type 3 |
|
|
cd40 ligand deficiency |
|
|
light fixation seizure syndrome |
|
|
acute myocarditis |
|
|
immunodeficiency with hyper-igm, type 1 |
|
UniProtKB/Swiss-Prot
TNR5_HUMAN- Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. {ECO:0000269 PubMed:11675497, ECO:0000269 PubMed:26545377}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for CD40
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CD40 Gene
Publications for CD40 Gene
- Individual and epistatic effects of genetic polymorphisms of B-cell co-stimulatory molecules on susceptibility to pemphigus foliaceus. (PMID: 19421221) Malheiros D … Petzl-Erler ML (Genes and immunity 2009) 3 22 44 58
- [Association between inflammatory cytokine CD40 gene polymorphism and risk of acute coronary syndrome]. (PMID: 19099972) Tian CX … Huang CX (Zhonghua xin xue guan bing za zhi 2008) 3 22 44 58
- Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE. (PMID: 17255560) Park JH … Shin HD (American journal of respiratory and critical care medicine 2007) 3 22 44 58
- CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. (PMID: 9718306) Pullen SS … Kehry MR (Biochemistry 1998) 3 4 22 58
- A genome-wide association study identifies three new risk loci for Kawasaki disease. (PMID: 22446962) Onouchi Y … US Kawasaki Disease Genetics Consortium (Nature genetics 2012) 3 44 58
Products for CD40 Gene
- R&D Systems Antibodies for CD40 (CD40/TNFRSF5)
- R&D Systems Proteins and Enzymes for CD40 (CD40/TNFRSF5)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for CD40 (CD40/TNFRSF5)
- R&D Systems cDNA Clones for CD40 (CD40/TNFRSF5)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CD40
- AM03135AF-N
- AM03135FC-N
- AM03135RP-N
- AM05671PU-N
- AM06355SU-N
- AM08347PU-N
- AM31223AF-N
- AM31223BT-N
- AM31223FC-N
- AM31223PU-N
- AM31223RP-N
- AP06445PU-N
- AP23319PU-N
- AP31189PU-N
- AP33488PU-N
- BM2542
- SM1102F
- SM1102FT
- SM1102P
- SM1102PT
- SM1102R
- SM1102RT
- TA311665
- TA318864
- TA320278
- TA320279
- TA346281
- TA346282
- TA351052
- TA353698
- TA807569
- CF807569
- TA807571
- CF807571
- TA807572
- CF807572
- TA807573
- CF807573
- TA807574
- CF807574
- TA807575
- CF807575
- TA807682
- CF807682
- TA807683
- CF807683
- TA807686
- CF807686
- TA807687
- CF807687
- UM800075
- UM870075
- Custom Assay ServicesOriGene ELISA Kits for CD40
- Search Origene for MassSpec and Protein Over-expression Lysates for CD40
- Origene Custom Protein Services for CD40
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD40
- Browse OriGene Inhibitory RNA Products For CD40
- OriGene qPCR primer pairs and template standards for CD40
- OriGene qPCR primer pairs for CD40
- OriGene CRISPR knockouts for CD40
- OriGene ORF clones in human for CD40
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD40
- GenScript: Next-day shipping of latest version cDNA ORF clones for CD40 in any vector
- GenScript Purified and Recombinant Proteins for CD40
- GenScript Custom Purified and Recombinant Proteins Services for CD40
- GenScript Custom Assay Services for CD40
- GenScript Custom overexpressing Cell Line Services for CD40
- GenScript: Design CRISPR guide RNA sequences for CD40
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD40
- Cell Signaling Technology (CST) Antibodies for CD40 (CD40)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CD40
- Sino Biological Cell Lysates for CD40
- Sino Biological Recombinant Proteins for CD40
- Sino Biological Antibodies for CD40
- Sino Biological Assays for CD40
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CD40
- Novus Biologicals proteins and lysates for CD40
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CD40
- Abcam proteins for CD40
- Abcam assays for CD40
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CD40
- Cloud-Clone Corp. Antibodies for CD40
- Cloud-Clone Corp. Proteins for CD40
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CD40
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD40
- VectorBuilder custom plasmid, inducible vectors for CD40
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD40
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CD40
- antibodies-online: Search results for 921 available CD40 Antibodies ranked by validation data
- Compare Top CD40 Antibodies
- Recommended
- 122 FACS Antibodies (anti-mouse)
- 59 WB Antibodies (anti-mouse)
- 41 IP Antibodies (anti-mouse)
- 26 IHC (fro) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 12 IHC Antibodies (anti-mouse)
- 10 ICFC Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 ELISPOT (Capture) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 1 IHC (zinc) Antibody (anti-mouse)
- 1 in vitro Antibody (anti-mouse)
- 230 WB Antibodies (anti-human)
- 171 FACS Antibodies (anti-human)
- 44 IHC Antibodies (anti-human)
- 34 IHC (p) Antibodies (anti-human)
- 23 IP Antibodies (anti-human)
- 20 IF Antibodies (anti-human)
- 20 IHC (fro) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IF/ICC Antibodies (anti-human)
- 8 ICFC Antibodies (anti-human)
- 6 ICC Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 ISt Antibody (anti-human)
- 1 IFA Antibody (anti-human)
- 34 WB Antibodies (anti-rat)
- 14 FACS Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 66 available CD40 Elisa Kits ranked by validation data
- Compare Top CD40 Elisa Kits
- antibodies-online: Search results for 65 available CD40 Proteins ranked by validation data
- Compare Top CD40 Proteins
- GeneTex CD40 antibody for CD40
- Search GeneTex for Proteins for CD40
- ViGene Biosciences adenoviral particle packaged cDNA for CD40 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD40 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD40 gene
- Search ViGene Biosciences for CD40
- Santa Cruz Biotechnology (SCBT) Antibodies for CD40
- Search Santa Cruz Biotechnology (SCBT) for CD40 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD40
- Search for CD40 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CD40
- "CD40 molecule, TNF receptor superfamily member 5" [96-086]
- "CD40 molecule, TNF receptor superfamily member 5" [96-089]
- [96-800]
- [96-801]
- Tumor necrosis factor receptor superfamily member 5 [96-982]
- Tumor necrosis factor receptor superfamily member 5 [96-983]
- tumor necrosis factor receptor superfamily member 5 precursor [97-060]
- tumor necrosis factor receptor superfamily member 5 precursor [97-061]
- "CD40 molecule, TNF receptor superfamily member 5" [90-269]
- CD40 molecule [90-394]
- CD40 molecule [91-296]
- CD40 molecule [91-887]
- Horizon Cell Lines for CD40
- genomics-online: cdna clones - Search results for 161 available CD40 gene related products
- Overview of 161 available CD40 gene related products
- orf clones - Search results for 161 available CD40 gene related products
- Overview of 161 available CD40 gene related products
- genomics-online: gRNA clones - Search results for 161 available CD40 gene related products
- Overview of 161 available CD40 gene related products
- genomics-online: primer clones - Search results for 161 available CD40 gene related products
- Overview of 161 available CD40 gene related products
- genomics-online: shRNA clones - Search results for 161 available CD40 gene related products
- Overview of 161 available CD40 gene related products
Sources for CD40 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111)