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Aliases for CD4 Gene

Aliases for CD4 Gene

  • CD4 Molecule 2 3
  • T-Cell Surface Glycoprotein CD4 2 3
  • T-Cell Surface Antigen T4/Leu-3 3 4
  • CD4 Antigen (P55) 2 3
  • CD4 Receptor 3
  • CD4 Antigen 4
  • CD4mut 3

External Ids for CD4 Gene

Summaries for CD4 Gene

Entrez Gene Summary for CD4 Gene

  • This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for CD4 Gene

CD4 (CD4 Molecule) is a Protein Coding gene. Diseases associated with CD4 include lymphatic system disease and okt4 epitope deficiency. Among its related pathways are TGF-Beta Pathway and TGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and enzyme binding.

UniProtKB/Swiss-Prot for CD4 Gene

  • Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts

Gene Wiki entry for CD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD4 Gene

Genomics for CD4 Gene

Genomic Location for CD4 Gene

Start:
6,786,858 bp from pter
End:
6,820,810 bp from pter
Size:
33,953 bases
Orientation:
Plus strand

Genomic View for CD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD4 Gene

Proteins for CD4 Gene

  • Protein details for CD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01730-CD4_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD4
    Protein Accession:
    P01730
    Secondary Accessions:
    • B2R737
    • D3DUS5
    • Q4ZGK2
    • Q5U066
    • Q9UDE5

    Protein attributes for CD4 Gene

    Size:
    458 amino acids
    Molecular mass:
    51111 Da
    Quaternary structure:
    • Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.
    Miscellaneous:
    • Primary receptor for HIV-1

    Three dimensional structures from OCA and Proteopedia for CD4 Gene

neXtProt entry for CD4 Gene

Proteomics data for CD4 Gene at MOPED

Post-translational modifications for CD4 Gene

  • Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys453
  • Glycosylation at Asn296 and Asn325

Other Protein References for CD4 Gene

No data available for DME Specific Peptides for CD4 Gene

Domains for CD4 Gene

Gene Families for CD4 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

UniProtKB/Swiss-Prot:

CD4_HUMAN
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • P01730
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • P01730
genes like me logo Genes that share domains with CD4: view

Function for CD4 Gene

Molecular function for CD4 Gene

GENATLAS Biochemistry: cell differentiation antigen CD4 (p55),59kDa,HIV & MHC class II receptor,identified by monoclonal antibodies T4,Leu-3a,91D6,transmembrane glycoprotein (see LAG3),containing a tissue-specific promoter made of an initiator-like sequence,an ETS and an ATF consensus site, and a locus control region like,see LCR-CD4
UniProtKB/Swiss-Prot Function: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts

Gene Ontology (GO) - Molecular Function for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 10922058
GO:0004872 receptor activity TAS 10413516
GO:0004888 transmembrane signaling receptor activity TAS 10358157
GO:0005201 extracellular matrix structural constituent NAS 12444132
GO:0005515 protein binding IPI 11113139
genes like me logo Genes that share ontologies with CD4: view
genes like me logo Genes that share phenotypes with CD4: view

Animal Models for CD4 Gene

MGI Knock Outs for CD4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD4 Gene

Localization for CD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD4 Gene

Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD4 Gene COMPARTMENTS Subcellular localization image for CD4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
endosome 4
extracellular 3
nucleus 3
cytoskeleton 2
cytosol 2
golgi apparatus 2
lysosome 2
mitochondrion 2
peroxisome 2
vacuole 2

Gene Ontology (GO) - Cellular Components for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IDA 17213291
genes like me logo Genes that share ontologies with CD4: view

Pathways for CD4 Gene

genes like me logo Genes that share pathways with CD4: view

Gene Ontology (GO) - Biological Process for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0006948 induction by virus of host cell-cell fusion IDA 9166430
GO:0006955 immune response NAS 8512039
GO:0007155 cell adhesion --
GO:0007165 signal transduction TAS 10358157
genes like me logo Genes that share ontologies with CD4: view

Compounds for CD4 Gene

(1) Drugbank Compounds for CD4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Antithymocyte globulin
  • rabbit ATG
target

(58) Novoseek inferred chemical compound relationships for CD4 Gene

Compound -log(P) Hits PubMed IDs
c-d4i 74.7 5
aurintricarboxylic acid 67.4 3
rantes 55.4 5
galactosylceramide 51.8 5
prostratin 50.4 6
genes like me logo Genes that share compounds with CD4: view

Transcripts for CD4 Gene

mRNA/cDNA for CD4 Gene

(6) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD4 Gene

CD4 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: -
SP12: -
SP13:

ExUns: 14 ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CD4 Gene

GeneLoc Exon Structure for
CD4
ECgene alternative splicing isoforms for
CD4

Expression for CD4 Gene

mRNA expression in normal human tissues for CD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD4 Gene

This gene is overexpressed in Spleen (8.4) and Whole Blood (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD4 Gene

SOURCE GeneReport for Unigene cluster for CD4 Gene Hs.631659

genes like me logo Genes that share expressions with CD4: view

Orthologs for CD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD4 36
  • 99.13 (n)
  • 98.91 (a)
CD4 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD4 36
  • 72.34 (n)
  • 60.47 (a)
CD4 37
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD4 36
  • 74.68 (n)
  • 62.14 (a)
mouse
(Mus musculus)
Mammalia Cd4 36
  • 69.48 (n)
  • 57.04 (a)
Cd4 16
Cd4 37
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD4 37
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD4 37
  • 28 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd4 36
  • 68.67 (n)
  • 55.23 (a)
chicken
(Gallus gallus)
Aves CD4 36
  • 43.76 (n)
  • 31.03 (a)
CD4 37
  • 24 (a)
OneToOne
Species with no ortholog for CD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD4 Gene

ENSEMBL:
Gene Tree for CD4 (if available)
TreeFam:
Gene Tree for CD4 (if available)

Paralogs for CD4 Gene

No data available for Paralogs for CD4 Gene

Variants for CD4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD4 Gene

P01730-CD4_HUMAN
The OKT monoclonal antibodies are widely used for the analysis of human peripheral blood T-lymphocytes. OKT4 reacts with T-helper/inducer lymphocytes. The OKT4 epitope of the CD4 cell-surface protein is polymorphic in white, black, and Japanese populations. The variable phenotypic expression is due a CD4 polymorphism. OKT4 positive individuals carry Arg-265 and OKT4 negative individuals carry Trp-265 [MIM:613949]

Sequence variations from dbSNP and Humsavar for CD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs743600 -- 6,797,153(-) AGCAG(C/T)GGCAA intron-variant
rs1055141 -- 6,817,197(+) CTGAG(C/T)TTGAA synonymous-codon, reference
rs1075538 -- 6,796,884(-) TATGG(A/G)AAAAG intron-variant
rs1075835 -- 6,796,251(+) CACTA(C/T)ACACA intron-variant
rs1075836 -- 6,796,384(+) GAAGA(C/G)AGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD4 Gene

Variant ID Type Subtype PubMed ID
nsv832323 CNV Loss 17160897
nsv593 CNV Loss 18451855
nsv832324 CNV Loss 17160897
esv2663865 CNV Deletion 23128226
nsv52513 CNV Loss 16902084
esv2745479 CNV Deletion 23290073
nsv898638 CNV Loss 21882294
dgv1353n71 CNV Loss 21882294

Relevant External Links for CD4 Gene

HapMap Linkage Disequilibrium report
CD4
Human Gene Mutation Database (HGMD)
CD4

Disorders for CD4 Gene

(1) OMIM Diseases for CD4 Gene (186940)

(97) University of Copenhagen DISEASES for CD4 Gene

(54) Novoseek inferred disease relationships for CD4 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 86.9 138
hiv infections 69.6 46
aids 57.2 23
virus infection 55.8 17
superinfection 42.6 6

Relevant External Links for CD4

Genetic Association Database (GAD)
CD4
Human Genome Epidemiology (HuGE) Navigator
CD4
genes like me logo Genes that share disorders with CD4: view

No data available for UniProtKB/Swiss-Prot for CD4 Gene

Publications for CD4 Gene

  1. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. (PMID: 12517957) Fragoso R. … Jin Y.J. (J. Immunol. 2003) 3 4 23
  2. Structural basis for the interaction between focal adhesion kinase and CD4. (PMID: 18078954) Garron M.L. … Arold S.T. (J. Mol. Biol. 2008) 3 4 23
  3. HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells. (PMID: 18725938) Schaefer M.R. … Collins K.L. (PLoS Pathog. 2008) 3 23
  4. High-affinity binding of southern African HIV type 1 subtype C envelope protein, gp120, to the CCR5 coreceptor. (PMID: 19018669) Fromme B.J. … Flanagan C.A. (AIDS Res. Hum. Retroviruses 2008) 3 23
  5. Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes. (PMID: 19066282) Barrero-Villar M. … Valenzuela-FernA!ndez A. (J. Cell. Sci. 2009) 3 23

Products for CD4 Gene

  • Addgene plasmids for CD4

Sources for CD4 Gene

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