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CD4 Gene

protein-coding   GIFtS: 73
GCID: GC12P006899

CD4 Molecule

(Previous names: CD4 antigen (p55), T-cell surface glycoprotein CD4)
  See CD4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CD4 Molecule1 2     CD4mut2
CD4 Antigen (P55)1 2     CD4 Receptor2
T-Cell Surface Glycoprotein CD41 2     CD4 Antigen3
T-Cell Surface Antigen T4/Leu-32 3     

External Ids:    HGNC: 16781   Entrez Gene: 9202   Ensembl: ENSG000000106107   OMIM: 1869405   UniProtKB: P017303   
ORGUL members:         

Export aliases for CD4 gene to outside databases

Previous GC identifers: GC12M007045 GC12M007130 GC12P006777 GC12P006769


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD4 Gene:
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex
class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only
in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of
the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as
an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central
nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been
identified in this gene. (provided by RefSeq, Aug 2010)

GeneCards Summary for CD4 Gene:
CD4 (CD4 molecule) is a protein-coding gene. Diseases associated with CD4 include okt4 epitope deficiency, and lymphatic system disease. GO annotations related to this gene include enzyme binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: CD4_HUMAN, P01730
Function: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.
Induces the aggregation of lipid rafts

Gene Wiki entry for CD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD4 gene promoter:
         TBP   AP-2alpha isoform 3   p300   AP-2alpha isoform 2   TFIID   STAT3   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD4 promoter sequence
   Search Chromatin IP Primers for CD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

CD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006899:  view genomic region     (about GC identifiers)

Start:
6,896,024 bp from pter      End:
6,929,976 bp from pter
Size:
33,953 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CD4_HUMAN, P01730 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD4 precursor  
Size: 458 amino acids; 51111 Da
Subunit: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is
part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu.
Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the
presence of HIV-1 gp120
Miscellaneous: Primary receptor for HIV-1
Selected PDB 3D structures from and Proteopedia for CD4 (see all 43):
1CDH (3D)        1CDI (3D)        1CDJ (3D)        1CDU (3D)        1CDY (3D)        1G9M (3D)    
Secondary accessions: B2R737 D3DUS5 Q4ZGK2 Q5U066 Q9UDE5

Explore the universe of human proteins at neXtProt for CD4: NX_P01730

Explore proteomics data for CD4 at MOPED

Post-translational modifications: 

  • Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts1
  • Ubiquitination2 at Lys453
  • Glycosylation2 at Asn296, Asn325
  • Modification sites at PhosphoSitePlus

  • See CD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000607.1  NP_001181943.1  NP_001181944.1  NP_001181945.1  NP_001181946.1  

    ENSEMBL proteins: 
     ENSP00000011653   ENSP00000445167   ENSP00000440720  
    Reactome Protein details: P01730

    CD4 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CD4
    Sino Biological Cell Lysate for CD4
    ProSpec Recombinant Protein for CD4
    Cloud-Clone Corp. Proteins for CD4

     
    Search eBioscience for Proteins for CD4 

     
    antibodies-online proteins for CD4 (73 products) 

     
    antibodies-online peptides for CD4

    CD4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD4
    R&D Systems Antibodies for CD4
    Cell Signaling Technology (CST) Antibodies for CD4 
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    Abcam antibodies for CD4 (P01730, P04234, P10966, P06729)
    Cloud-Clone Corp. Antibodies for CD4
    ThermoFisher Antibody for CD4
    antibodies-online antibodies for CD4 

    CD4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CD4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD4
    Cloud-Clone Corp. CLIAs for CD4
    Search eBioscience for ELISAs for CD4 
    antibodies-online kits for CD4 (34 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 9):
     IPR008424 Ig_C2-set
     IPR021963 Tcell_CD4_Cterm
     IPR015274 CD4-extracel
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P01730

    ProtoNet protein and cluster: P01730

    3 Blocks protein domains:
    IPB000973 T-cell surface glycoprotein CD4 signature
    IPB003596 Immunoglobulin V-type
    IPB008424 T-cell surface antigen CD2


    UniProtKB/Swiss-Prot: CD4_HUMAN, P01730
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD4_HUMAN, P01730
    Function: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.
    Induces the aggregation of lipid rafts

         Genatlas biochemistry entry for CD4:
    cell differentiation antigen CD4 (p55),59kDa,HIV & MHC class II receptor,identified by monoclonal antibodies
    T4,Leu-3a,91D6,transmembrane glycoprotein (see LAG3),containing a tissue-specific promoter made of an
    initiator-like sequence,an ETS and an ATF consensus site, and a locus control region like,see LCR-CD4

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IPI10922058
    GO:0004872receptor activity TAS10413516
    GO:0004888transmembrane signaling receptor activity TAS10358157
    GO:0005201extracellular matrix structural constituent NAS12444132
    GO:0005515protein binding IPI11113139
         
    Find genes that share ontologies with CD4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CD4:
     Decreased p24 protein expressi 

         11 MGI mutant phenotypes (inferred from 21 alleles(MGI details for Cd4):
     cellular  digestive/alimentary  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  nervous system  no phenotypic analysis 
     normal 

    Find genes that share phenotypes with CD4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD4: Cd4tm1Doi Cd4tm1Litt Cd4tm1Knw Cd4tm2Litt Cd4tm1Mak

       genOway: Develop your customized and physiologically relevant rodent model for CD4

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CD4 (see all 17):
    hsa-miR-485-5p hsa-miR-181c hsa-miR-548v hsa-miR-221 hsa-miR-2115 hsa-miR-3154 hsa-miR-181b hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmidCD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD4
    Predesigned siRNA for gene silencing in human, mouse, rat CD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD4

    Clone
    Products:
         
    OriGene clones in human, mouse for CD4 (see all 13)
    OriGene ORF clones in mouse, rat for CD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CD4 (NM_000616)
    Sino Biological Human cDNA Clone for CD4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD4
    Addgene plasmids for CD4 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CD4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD4

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12725 VA4-13453 VA6-13603) for CD4 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD4_HUMAN, P01730: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed
    from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target
    it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160
    that interacts with, and sequesters CD4 in the endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    endosome4
    extracellular3
    nucleus3
    cytoskeleton2
    cytosol2
    golgi apparatus2
    lysosome2
    mitochondrion2
    peroxisome2
    vacuole2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome TAS--
    GO:0005788endoplasmic reticulum lumen IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0009897external side of plasma membrane IDA17213291

    Find genes that share ontologies with CD4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD4 About   (see all 39)  
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    T cell receptor signaling pathway0.38
    TCR Signaling Pathway0.36
    2CD28 co-stimulation
    Costimulation by the CD28 family0.44
    CTLA4 Signaling0.30
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4HIV Life Cycle
    HIV Life Cycle0.91
    Early Phase of HIV Life Cycle0.00
    HIV Infection0.62
    Binding and entry of HIV virion0.00
    Host Interactions of HIV factors0.60
    5Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.83
    PD-1 signaling0.72
    Phosphorylation of CD3 and TCR zeta chains0.83
    Generation of second messenger molecules0.62


    Find genes that share SuperPaths with CD4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for CD4
        Th1 Differentiation
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD4 (see all 26)
        Calcium Mediated T-Cell Apoptosis
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for CD4
        Lymphocyte Signaling

    4 GeneGo (Thomson Reuters) Pathways for CD4
        Immune response Antigen presentation by MHC class II
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    Selected BioSystems Pathways for CD4 (see all 10)
        Cytokines and Inflammatory Response
    TCR Signaling Pathway
    IL12-mediated signaling events
    Arf1 pathway
    TCR signaling in naive CD4+ T cells


    Selected Reactome Pathways for CD4 (see all 9)
        Alpha-defensins
    Nef Mediated CD4 Down-regulation
    Translocation of ZAP-70 to Immunological synapse
    Binding and entry of HIV virion
    Downstream TCR signaling


    5 Kegg Pathways  (Kegg details for CD4):
        Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Hematopoietic cell lineage
    T cell receptor signaling pathway
    Primary immunodeficiency

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD4 (see all 13): 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD4 (P017301, 2, 3 ENSP000000116534) via UniProtKB, MINT, STRING, and/or I2D (see all 271)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR3C1P041501, 2, 3, ENSP000002315094EBI-353826,EBI-493507 MINT-3373972 MINT-3373954 I2D: score=1 STRING: ENSP00000231509
    HLA-DPA1P200363, ENSP000003935664I2D: score=2 STRING: ENSP00000393566
    HLA-DQA2P019063, ENSP000003640764I2D: score=2 STRING: ENSP00000364076
    ENSG00000232575P074373, ENSP000004100714I2D: score=1 STRING: ENSP00000410071
    ENSG00000168384P200363I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production IEA--
    GO:0006948induction by virus of host cell-cell fusion IDA9166430
    GO:0006955immune response NAS8512039
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS10358157

    Find genes that share ontologies with CD4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD4

    1 DrugBank Compound for CD4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antithymocyte globulinrabbit ATG (see all 3)--target--12586600

    Selected Novoseek inferred chemical compound relationships for CD4 gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    c-d4i 74.7 6 12208966 (3), 12487827 (2)
    aurintricarboxylic acid 67.4 3 1691563 (1), 1704066 (1), 1979910 (1)
    rantes 55.4 5 17015796 (1), 10649782 (1), 11064099 (1), 9311806 (1) (see all 5)
    galactosylceramide 51.8 6 12586555 (2), 11201521 (1), 12709027 (1), 11262202 (1)
    prostratin 50.4 8 15457682 (5), 11698284 (1)
    dextran sulfate 47.4 1 7524738 (1)
    mdms 46.8 5 11920312 (3), 10445810 (1)
    tyrosine 40.5 58 2040625 (3), 1532148 (3), 9117451 (2), 1834739 (2) (see all 32)
    zidovudine 36.2 1 1355606 (1)
    tarc 31.4 3 15805991 (3)



    Find genes that share compounds with CD4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD4 gene (5 alternative transcripts): 
    NM_000616.4  NM_001195014.2  NM_001195015.2  NM_001195016.2  NM_001195017.2  

    Unigene Cluster for CD4:

    CD4 molecule
    Hs.631659  [show with all ESTs]
    Unigene Representative Sequence: NM_001195014
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535707 ENST00000011653(uc001qqv.2 uc010sfj.2 uc009zfc.2 uc010sfl.2 uc010sfk.2 uc010sfm.1)
    ENST00000536610 ENST00000544344 ENST00000541982 ENST00000538827(uc009zfa.2 uc009zfb.2)
    ENST00000437800(uc009zez.2) ENST00000535466 ENST00000536590 ENST00000539492
    ENST00000536563 ENST00000543755
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CD4 (see all 17):
    hsa-miR-485-5p hsa-miR-181c hsa-miR-548v hsa-miR-221 hsa-miR-2115 hsa-miR-3154 hsa-miR-181b hsa-miR-3173-3p
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    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CD4 (NM_000616)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD4
    Addgene plasmids for CD4 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CD4
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    Flow Cytometry
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    Additional mRNA sequence: 

    AK300052.1 AK303968.1 AK308344.1 AK310652.1 AK310677.1 AK310687.1 AK311495.1 AK312828.1 
    AK315898.1 AK316461.1 AK316462.1 BC025782.1 BT019791.1 BT019811.1 M12807.1 U40625.1 

    Selected DOTS entries (see all 27):

    DT.121200495  DT.121200491  DT.95220970  DT.99926928  DT.100770953  DT.121200507  DT.121200514  DT.121200496 
    DT.102841595  DT.121200541  DT.121200492  DT.121200398  DT.121200534  DT.121200502  DT.121200538  DT.121200551 
    DT.92018945  DT.91693171  DT.100771947  DT.102841604  DT.102841608  DT.121200402  DT.121200493  DT.121200539 

    4 AceView cDNA sequences:

    BC025782 M12807 NM_000616 U40625 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD4 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^
    SP1:                          -     -     -     -                             -                 -     -     -                                         -     -   
    SP2:                          -     -                                                                                                                           
    SP3:                          -     -     -     -                             -                                                                                 
    SP4:                          -     -           -                                                                                                               
    SP5:                                      -     -                                                                                                               

    ExUns: 14 ^ 15a · 15b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGGGTCC
    CD4 Expression
    About this image


    CD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 16 entries
             T-Regulatory Cells Peripheral Blood
             Regulatory T cells
     
     Thymus (Hematopoietic System)    fully expand to see all 9 entries
             T Helper Cells Thymus
     
     Liver (Hepatobiliary System)
             Sinusoidal Endothelial Cells Sinusoids
     
     Endothelium (Cardiovascular System)
             Sinusoidal Endothelial Cells Sinusoids
     
     Lymph (Hematopoietic System)
             Regulatory T lymphocytes
    CD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631659
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD4 (see all 13): 
              HIV Host Response in human mouse rat
              Cell Surface Markers in human mouse rat
              Multiple Sclerosis in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD4 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd41 , 5 CD4 antigen1, 5 69.48(n)1
    57.04(a)1
      6 (59.17 cM)5
    125041  NM_013488.21  NP_038516.11 
     1248646925 
    chicken
    (Gallus gallus)
    Aves CD41 CD4 molecule 43.76(n)
    31.03(a)
      395362  NM_204649.1  NP_989980.1 


    ENSEMBL Gene Tree for CD4 (if available)
    TreeFam Gene Tree for CD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CD4_HUMAN, P01730: The OKT monoclonal antibodies are widely used for the analysis of human peripheral blood
    T-lymphocytes. OKT4 reacts with T-helper/inducer lymphocytes. The OKT4 epitope of the CD4 cell-surface protein is
    polymorphic in white, black, and Japanese populations. The variable phenotypic expression is due a CD4
    polymorphism. OKT4 positive individuals carry Arg-265 and OKT4 negative individuals carry Trp-265 [MIM:613949]


    Selected SNPs for CD4 (see all 1218)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110643891,2
    A--6828490(+) GTTGGC/GGGGTG 5 -- us2k10--------
    rs289201691,2
    C,F--6828525(+) GCTGAG/AGCAGG 5 -- us2k15Minor allele frequency- A:0.05NS 168
    rs1896013491,2
    --6828554(+) GAGGCA/GGAGGT 5 -- us2k10--------
    rs1820596521,2
    --6828593(+) CTTCAA/GCCTGG 5 -- us2k10--------
    rs79678881,2
    C--6828772(+) gcttgA/Gacccg 5 -- us2k10--------
    rs1892086221,2
    --6828830(+) CTGGGA/CAACAG 5 -- us2k10--------
    rs110643911,2
    C,F,A,H--6829053(+) ACTAGC/AGTTTT 5 -- us2k123Minor allele frequency- A:0.20NS EA NA WA CSA 2414
    rs1453694501,2
    C--6829054(+) TAGAG-/TTTTC/TTTTCTTTTCT
    TTTCCTTTCTTTTCTTTTC
    TTTTC
    10 -- us2k1 cds10--------
    rs665378221,2
    C--6829055(+) AGAGT-/TTTTC/TTTTCTTT
    TCTTTTCCTTTCTTTTC
    TTTCT
    5 -- us2k10--------
    rs1418638221,2
    --6829065(+) TTTCT-/TTTCC 
            
    TTTCT
    5 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD4 (6896024 - 6929976 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663865CNV Deletion23128226
    esv2745479CNV Deletion23290073
    nsv593CNV Loss18451855
    dgv1353n71CNV Loss21882294
    nsv832323CNV Loss17160897
    nsv898638CNV Loss21882294
    nsv52513CNV Loss16902084
    nsv832324CNV Loss17160897

    Human Gene Mutation Database (HGMD): CD4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD4
    DNA2.0 Custom Variant and Variant Library Synthesis for CD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186940   
    OMIM disorders: 613949  
    20 diseases for CD4:    
    About MalaCards
    okt4 epitope deficiency    lymphatic system disease    pneumocystosis    anogenital venereal wart
    mycobacterium avium complex disease    blastic plasmacytoid dendritic cell    microsporidiosis    listeriosis
    blood protein disease    anus cancer    sialadenitis    chickenpox
    spinal cord disease    hypersplenism    infectious mononucleosis    histoplasmosis
    cryptococcosis    primary immunodeficiency disease    cryptosporidiosis    hiv-1

    Selected diseases from the University of Copenhagen DISEASES database for CD4 (see all 97):
    Acquired immunodeficiency syndrome     Tuberculosis     Hypersensitivity reaction type II disease     Pneumocystosis
    Lymphoma     Candidiasis     Skin disease     Leukopenia
    Retinitis     Pneumonia     Multiple sclerosis     Arthritis
    Asthma     Primary immunodeficiency disease     Kaposi's sarcoma     Tetanus
    Leishmaniasis     Leukemia     Hepatitis     Toxoplasmosis

    Find genes that share disorders with CD4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD4 gene (see all 54)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 86.9 292 1975594 (4), 9367961 (4), 2040625 (3), 7521692 (3) (see all 99)
    hiv infections 69.6 53 1706342 (3), 1983967 (2), 1674171 (2), 11689637 (2) (see all 41)
    aids 57.2 28 7691271 (2), 2297204 (2), 1774603 (2), 2184372 (1) (see all 20)
    virus infection 55.8 18 1975594 (2), 1983967 (1), 1939640 (1), 15540608 (1) (see all 16)
    superinfection 42.6 6 16873261 (3), 7474070 (1), 8005387 (1), 20465832 (1)
    antibody-dependent enhancement 41.9 4 1976824 (2), 16987062 (2)
    anaplastic large cell lymphoma 35.2 1
    aids-related complex 33.4 3 2297204 (2), 1774603 (1)
    vesicular stomatitis 29.8 2 11704677 (1), 1310767 (1)
    leukemia t-cell 28.2 1 1532148 (1)

    Genetic Association Database (GAD): CD4
    Human Genome Epidemiology (HuGE) Navigator: CD4 (270 documents)

    Export disorders for CD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD4 gene, integrated from 10 sources (see all 1839):
    (articles sorted by number of sources associating them with CD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis for the interaction between focal adhesion kinase and CD4. (PubMed id 18078954)1, 2, 9 Garron M.L....Arold S.T. (J. Mol. Biol. 2008)
    2. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. (PubMed id 12517957)1, 2, 9 Fragoso R.... Jin Y.J. (J. Immunol. 2003)
    3. CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. (PubMed id 20924289)1, 4 Hennig B.J....Sirugo G. (J. Acquir. Immune Defic. Syndr. 2011)
    4. Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population. (PubMed id 19843086)1, 4 Zamani M....Mansouri P. (Clin. Exp. Dermatol. 2010)
    5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    6. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    7. Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition. (PubMed id 20132229)1, 4 Choi R.Y....Fowke K. (Clin. Exp. Immunol. 2010)
    8. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    9. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    10. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 920 HGNC: 1678 AceView: CD4 Ensembl:ENSG00000010610 euGenes: HUgn920
    ECgene: CD4 Kegg: 920 H-InvDB: CD4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cd4/
    Wikipedia http://en.wikipedia.org/wiki/CD4

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD4 gene:
    Search GeneIP for patents involving CD4

    Licensable Technologies for CD4 gene:
     Salk Institute: Alpha-Complementation Viral Fusion Assay
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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