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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD4 Gene

protein-coding GIFtS: 72
GCID: GC12P006899

CD4 molecule

(Previous names: CD4 antigen (p55), T-cell surface glycoprotein CD4 )

Explore 196 diseases affiliated with
CD4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD4 Molecule¹ ²		CD4mut²
CD4 Antigen (P55)¹ ²		CD4 Receptor²
T-Cell Surface Glycoprotein CD4¹ ²		CD4 Antigen³
T-Cell Surface Antigen T4/Leu-3² ³

External Ids:	HGNC: 1678¹	Entrez Gene: 920²	Ensembl: ENSG00000010610⁷	OMIM: 186940⁵	UniProtKB: P01730³

Export aliases for CD4 gene to outside databases

Previous GC identifers: GC12M007045 GC12M007130 GC12P006777 GC12P006769

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD4:

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class

II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T

lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the

brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an

important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous

system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this

gene. (provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: CD4_HUMAN, P01730

Function: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.

Induces the aggregation of lipid rafts

Gene Wiki entry for CD4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009759.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD4 gene promoter:
TBP AP-2alpha isoform 3 p300 AP-2alpha isoform 2 TFIID STAT3 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD4 promoter sequence

Search SABiosciences Chromatin IP Primers for CD4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

CD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD4 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P006899: view genomic region (about GC identifiers)

Start:	6,896,024 bp from pter	End:	6,929,976 bp from pter
Size:	33,953 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD4_HUMAN, P01730 (See protein sequence)

Recommended Name: T-cell surface glycoprotein CD4 precursor

Size: 458 amino acids; 51111 Da

Subunit: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part

of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with

Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from

plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to

lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that

interacts with, and sequesters CD4 in the endoplasmic reticulum

Miscellaneous: Primary receptor for HIV-1

6/42 PDB 3D structures from and Proteopedia for CD4 (see all 42):

1CDH (3D)

1CDI (3D)

1CDJ (3D)

1CDU (3D)

1CDY (3D)

1G9M (3D)

Secondary accessions: B2R737 D3DUS5 Q4ZGK2 Q5U066 Q9UDE5

Explore the universe of human proteins at neXtProt for CD4: NX_P01730

Post-translational modifications:

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01730

CD4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_000607.1 NP_001181943.1 NP_001181944.1 NP_001181945.1 NP_001181946.1

ENSEMBL proteins:

ENSP00000011653 ENSP00000445167 ENSP00000440720

Reactome Protein details: P01730
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD4
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CD4 OriGene Protein Over-expression Lysate (see all 2): CD4 OriGene Custom Protein Services for CD4
	GenScript Custom Purified and Recombinant Proteins Services for CD4
	Novus Biologicals CD4 Proteins Novus Biologicals CD4 Lysates
	Sino Biological Recombinant Protein for CD4
	ProSpec Recombinant Protein for CD4
	Uscn Proteins for CD4

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005769	early endosome	TAS	--
GO:0005788	endoplasmic reticulum lumen	IEA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0009897	external side of plasma membrane	IDA	17213291

CD4 for ontologies About GeneDecksing

CD4 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD4
	R&D Systems Antibodies for CD4
	Cell Signaling Technology (CST) Antibodies for CD4
	OriGene Antibodies (see all 25): CD4 OriGene Custom Antibody Services for CD4
	GenScript Custom Superior Antibodies Services for CD4
	Novus Biologicals CD4 Antibodies
	Abcam antibodies for CD4
	Uscn Antibodies for CD4
	ThermoFisher Antibody for CD4

Assay Products for CD4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD4 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR008424 Ig_C2-set

IPR021963 Tcell_CD4_Cterm

IPR015274 CD4-extracel

IPR003596 Ig_V-set_subgr

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry P01730

ProtoNet protein and cluster: P01730

3 Blocks protein families:

IPB000973 T-cell surface glycoprotein CD4 signature

IPB003596 Immunoglobulin V-type

IPB008424 T-cell surface antigen CD2

UniProtKB/Swiss-Prot: CD4_HUMAN, P01730

Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD4_HUMAN, P01730

Function: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.

Induces the aggregation of lipid rafts

Genatlas biochemistry entry for CD4:

cell differentiation antigen CD4 (p55),59kDa,HIV & MHC class II receptor,identified by monoclonal antibodies

T4,Leu-3a,91D6,transmembrane glycoprotein (see LAG3),containing a tissue-specific promoter made of an initiator-like

sequence,an ETS and an ATF consensus site, and a locus control region like,see LCR-CD4

miRNA Products:		OriGene 3'-UTR Clone: CD4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD4
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CD4 (see all 17):
		hsa-miR-485-5p hsa-miR-181c hsa-miR-548v hsa-miR-221 hsa-miR-2115 hsa-miR-3154 hsa-miR-181b hsa-miR-3173-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CD4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD4 (see all 7) OriGene shRNA RFP: CD4 OriGene siRNA: CD4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD4 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): CD4 (NM_000616)
		Sino Biological Human cDNA Clone for CD4
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD4
		Search LifeMap BioReagents cell lines for CD4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD4

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001948	glycoprotein binding	IPI	10922058
GO:0004872	receptor activity	TAS	10413516
GO:0004888	transmembrane signaling receptor activity	TAS	10358157
GO:0005201	extracellular matrix structural constituent	NAS	12444132
GO:0005515	protein binding	IPI	19333378

CD4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CD4:

Decreased p24 protein expressi

Animal Models:
Mouse knock-outs for CD4: Cd4^tm1Doi Cd4^tm1Litt Cd4^tm1Knw Cd4^tm2Litt Cd4^tm1Mak
10 MGI mutant phenotypes (inferred from 19 alleles) (MGI details for Cd4):

cellular	digestive/alimentary	hematopoietic system	homeostasis/metabolism	immune system
integument	mortality/aging	nervous system	no phenotypic analysis	normal

CD4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/45 super-pathways (see all 45) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57	SOCS Pathway	0.29

Translocation of ZAP-70 to Immunological synapse

	Translocation of ZAP-70 to Immunological synapse	1.00			PD-1 signaling	0.76
	Phosphorylation of CD3 and TCR zeta chains	0.85			Generation of second messenger molecules	0.64

PEDF Induced Signaling

	STAT3 Pathway	0.47			PGC1Alpha Pathway	0.33
	NFAT Signaling and Lymphocyte Interactions	0.37			Glucocorticoid Receptor Signaling	0.27

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

ICos-ICosL Pathway in T-Helper Cell

	ICos-ICosL Pathway in T-Helper Cell	1.00			Calcium Mediated T-Cell Apoptosis	0.31
	CD28 Signaling in T-Helper Cell	0.66

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for CD4

	Immune response Antigen presentation by MHC class II
	G-protein signaling N-RAS regulation pathway
	Immune response IL-22 signaling pathway
	Immune response T cell receptor signaling pathway

2 R&D Systems Pathways for CD4

	Th1 Differentiation
	Th17 Differentiation

5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD4 (see all 26)

	Calcium Mediated T-Cell Apoptosis
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

1 Cell Signaling Technology (CST) Pathway for CD4

Lymphocyte Signaling

4 GeneGo (Thomson Reuters) Pathways for CD4

	Immune response Antigen presentation by MHC class II
	Immune response T cell receptor signaling pathway
	Immune response IL-22 signaling pathway
	G-protein signaling N-RAS regulation pathway

5/10 BioSystems Pathways for CD4 (see all 10)

	Cytokines and Inflammatory Response
	TCR Signaling Pathway
	Arf1 pathway
	Notch-mediated HES/HEY network
	IL12-mediated signaling events

5/24 Reactome Pathways for CD4 (see all 24)

	Costimulation by the CD28 family
	The role of Nef in HIV-1 replication and disease pathogenesis
	Disease
	Nef Mediated CD4 Down-regulation
	HIV Infection

5 Kegg Pathways (Kegg details for CD4):

	Cell adhesion molecules (CAMs)
	Antigen processing and presentation
	Hematopoietic cell lineage
	T cell receptor signaling pathway
	Primary immunodeficiency

CD4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/225 Interacting proteins for CD4 (P01730^{2, 3} ENSP00000011653⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 225)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NR3C1	P04150²^,³, ENSP00000231509⁴	MINT-3373972 MINT-3373954 I2D: score=1 STRING: ENSP00000231509
HLA-DQB1	P01920³, ENSP00000382034⁴	I2D: score=3 STRING: ENSP00000382034
LCK	P06239²^,³, ENSP00000337825⁴	MINT-3375588 MINT-3373991 MINT-66002 I2D: score=5 STRING: ENSP00000337825
ENSG00000225824	P01920³	I2D: score=3
ENSG00000231286	P01920³	I2D: score=3

About this table

Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001816	cytokine production	IEA	--
GO:0006948	induction by virus of host cell-cell fusion	IDA	9166430
GO:0006955	immune response	NAS	8512039
GO:0007155	cell adhesion	IEA	--
GO:0007165	signal transduction	TAS	9558100

CD4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD4

1 DrugBank Compound for CD4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Antithymocyte globulin	rabbit ATG (see all 3)	--	target	--	12586600

10/58 Novoseek chemical compound relationships for CD4 gene (see all 58) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
c-d4i	74.7	6	12208966 (3), 12487827 (2)
aurintricarboxylic acid	67.4	3	1691563 (1), 1704066 (1), 1979910 (1)
rantes	55.4	5	17015796 (1), 10649782 (1), 11064099 (1), 9311806 (1) (see all 5)
galactosylceramide	51.8	6	12586555 (2), 11201521 (1), 12709027 (1), 11262202 (1)
prostratin	50.4	8	15457682 (5), 11698284 (1)
dextran sulfate	47.4	1	7524738 (1)
mdms	46.8	5	11920312 (3), 10445810 (1)
tyrosine	40.5	58	2040625 (3), 1532148 (3), 9117451 (2), 1834739 (2) (see all 32)
zidovudine	36.2	1	1355606 (1)
tarc	31.4	3	15805991 (3)

Search CenterWatch for drugs/clinical trials and news about CD4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD4 gene (5 alternative transcripts):

NM_000616.4 NM_001195014.2 NM_001195015.2 NM_001195016.2 NM_001195017.2

Unigene Cluster for CD4:

CD4 molecule

Hs.631659 [show with all ESTs]

Unigene Representative Sequence: NM_001195014

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000535707 ENST00000011653(uc001qqv.2 uc010sfj.2 uc009zfc.2 uc010sfl.2 uc010sfk.2 uc010sfm.1)

ENST00000536610 ENST00000544344 ENST00000541982 ENST00000538827(uc009zfa.2 uc009zfb.2)

ENST00000437800(uc009zez.2) ENST00000535466 ENST00000536590 ENST00000539492

ENST00000536563 ENST00000543755

miRNA Products:		OriGene 3'-UTR Clone: CD4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD4
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CD4 (see all 17):
		hsa-miR-485-5p hsa-miR-181c hsa-miR-548v hsa-miR-221 hsa-miR-2115 hsa-miR-3154 hsa-miR-181b hsa-miR-3173-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CD4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD4 (see all 7) OriGene shRNA RFP: CD4 OriGene siRNA: CD4
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD4 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): CD4 (NM_000616)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CD4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD4

Additional cDNA sequence:

AK300052.1 AK303968.1 AK308344.1 AK310652.1 AK310677.1 AK310687.1 AK311495.1 AK312828.1

AK315898.1 AK316461.1 AK316462.1 BC025782.1 BT019791.1 BT019811.1 M12807.1 U40625.1

24/27 DOTS entries (see all 27):

DT.121200495 DT.121200491 DT.95220970 DT.99926928 DT.100770953 DT.121200507 DT.121200514 DT.121200496

DT.102841595 DT.121200541 DT.121200492 DT.121200398 DT.121200534 DT.121200502 DT.121200538 DT.121200551

DT.92018945 DT.91693171 DT.100771947 DT.102841604 DT.102841608 DT.121200402 DT.121200493 DT.121200539

4 AceView cDNA sequences:

BC025782 M12807 NM_000616 U40625

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CD4 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^
SP1:									-		-		-		-										-						-		-		-														-		-
SP2:									-		-
SP3:									-		-		-		-										-
SP4:									-		-				-
SP5:													-		-

ExUns:	14	^	15a	·	15b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CD4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAGGGTCC

About this image

CD4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Blood

Sinusoidal Endothelial Cells

Endothelium

Blood

Hematopoietic Stem Cells

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

Primitive gut tube-like cells (A scalable, suspensi...)

See CD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD4

SOURCE GeneReport for Unigene cluster: Hs.631659

SABiosciences Expression via Pathway-Focused PCR Arrays including CD4 (see all 13):

HIV Host Response in human mouse rat

Cell Surface Markers in human mouse rat

Multiple Sclerosis in human mouse rat

Lymphoma in human mouse rat

T-cell & B-cell Activation in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CD4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD4 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd4^{1 , 5}	CD4 antigen^{1, 5}	69(n)¹ 56.33(a)¹		6 (59.17 cM)⁵ 12504¹ NM_013488.2¹ NP_038516.1¹ 124864692⁵
chicken (Gallus gallus)	Aves	CD4¹	CD4 molecule	44.21(n) 31.69(a)		395362 NM_204649.1 NP_989980.1

ENSEMBL Gene Tree for CD4 (if available)
TreeFam Gene Tree for CD4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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UniProtKB/Swiss-Prot: CD4_HUMAN, P01730

Polymorphism: The OKT monoclonal antibodies are widely used for the analysis of human peripheral blood T-lymphocytes.

OKT4 reacts with T-helper/inducer lymphocytes. The OKT4 epitope of the CD4 cell-surface protein is polymorphic in

white, black, and Japanese populations. The variable phenotypic expression is due a CD4 polymorphism. OKT4 positive

individuals carry Arg-265 and OKT4 negative individuals carry Trp-265 [MIM:613949]

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11064389^1,2	A	--	6896957(+)	`GTTGGC/GGGGTG`	5	--	us2k¹		0	--	--	--	--
rs28920169^1,2	C,F,	--	6896992(+)	`GCTGAG/AGCAGG`	5	--	us2k¹		5		NS	168
rs189601349^1,2		--	6897021(+)	`GAGGCA/GGAGGT`	5	--	us2k¹		0	--	--	--	--
rs182059652^1,2		--	6897060(+)	`CTTCAA/GCCTGG`	5	--	us2k¹		0	--	--	--	--
rs7967888^1,2	C,	--	6897239(+)	`gcttgA/Gacccg`	5	--	us2k¹		0	--	--	--	--
rs189208622^1,2		--	6897297(+)	`CTGGGA/CAACAG`	5	--	us2k¹		0	--	--	--	--
rs10849516^1,2	A	--	6897340(+)	`AAAAAT/AATATA`	5	--	us2k¹ tfbs³		1		NA	2
rs144561538^1,2	C,	--	6897340(+)	`AAAAA-/TAT ATATATATATA`	5	--	us2k¹		0	--	--	--	--
rs201827711^1,2		--	6897340(+)	`AAAAA-/TATATATA`	5	--	us2k¹		0	--	--	--	--
rs11064391^1,2	C,F,A,H,	--	6897527(+)	`ACTAGC/AGTTTT`	5	--	us2k¹		23		NS EA NA WA CSA	2414

HapMap Linkage Disequilibrium report for CD4 (6896024 - 6929976 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD4
1 Indel: 11598
Human Gene Mutation Database (HGMD): CD4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD4 for disorders           About GeneDecksing

OMIM gene information: 186940    OMIM disorders: --

20/196 diseases for CD4 (see all 196):    About MalaCards

anogenital venereal wart mycobacterium avium complex disease immunodeficiency adult-onset still's disease

hypersensitivity reaction type ii disease polyclonal hypergammaglobulinemia spinal cord disease progressive multifocal leukoencephalopathy

tropical spastic paraparesis human immunodeficiency virus infectious disease mycosis fungoides graft versus host disease

molluscum contagiosum spastic paraparesis allergic contact dermatitis contact dermatitis

lupus erythematosus abdominal aortic aneurysm anaplastic large cell lymphoma aids dementia complex

20/103 diseases from the University of Copenhagen DISEASES database for CD4 (see all 103):

Human immunodeficiency virus infectious disease Tuberculosis Hypersensitivity reaction type II disease Pneumocystosis

Lymphoma Candidiasis Retinitis Leukopenia

Pneumonia Multiple sclerosis Arthritis Asthma

Influenza Kaposi's sarcoma Primary immunodeficiency disease Tetanus

Dermatitis Hepatitis Leishmaniasis Leukemia

10/54 Novoseek disease relationships for CD4 gene (see all 54) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	86.9	292	1975594 (4), 9367961 (4), 2040625 (3), 7521692 (3) (see all 99)
hiv infections	69.6	53	1706342 (3), 1983967 (2), 1674171 (2), 11689637 (2) (see all 41)
aids	57.2	28	7691271 (2), 2297204 (2), 1774603 (2), 2184372 (1) (see all 20)
virus infection	55.8	18	1975594 (2), 1983967 (1), 1939640 (1), 15540608 (1) (see all 16)
superinfection	42.6	6	16873261 (3), 7474070 (1), 8005387 (1), 20465832 (1)
antibody-dependent enhancement	41.9	4	1976824 (2), 16987062 (2)
anaplastic large cell lymphoma	35.2	1
aids-related complex	33.4	3	2297204 (2), 1774603 (1)
vesicular stomatitis	29.8	2	11704677 (1), 1310767 (1)
leukemia t-cell	28.2	1	1532148 (1)

Genetic Association Database (GAD): CD4
Human Genome Epidemiology (HuGE) Navigator: CD4 (270 documents)

Export disorders for CD4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD4 gene, integrated from 9 sources (see all 1813):
(articles sorted by number of sources associating them with CD4)

Utopia: connect your pdf to the dynamic
world of online information

Structural basis for the interaction between focal adhesion kinase and CD4. (PubMed id 18078954)^{1, 2, 9} Garron M.L....Arold S.T. (2008)
Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. (PubMed id 12517957)^{1, 2, 9} Fragoso R.... Jin Y.J. (2003)
Protein minimization of the gp120 binding region of human CD4. (PubMed id 16331979)^{1, 2} Sharma D.... Varadarajan R. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
Molecular genetic analysis of TPO and CD4 loci among two endogamous ethnic groups of Maharashtra in Western India. (PubMed id 15317218)^{1, 4} Das B. and Seshadri M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression. (PubMed id 14557639)^{1, 4} Casartelli N....Doria M. (2003)
Cloning of ACP33 as a novel intracellular ligand of CD4. (PubMed id 11113139)^{1, 2} Zeitlmann L.... Kolanus W. (2001)
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. (PubMed id 9641677)^{1, 2} Kwong P.D....Hendrickson W.A. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 920	HGNC: 1678	AceView: CD4	Ensembl:ENSG00000010610	euGenes: HUgn920
ECgene: CD4	Kegg: 920	H-InvDB: CD4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD4	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cd4/
Wikipedia	http://en.wikipedia.org/wiki/CD4

Intellectual Property for CD4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD4 gene:
Search GeneIP for patents involving CD4

Licensable Technologies for CD4 gene:

Salk Institute:

Alpha-Complementation Viral Fusion Assay

GeneCards and IP:
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