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CD4 Gene

protein-coding GIFtS: 71

GC12P006769

CD4 molecule
(Previous name: CD4 antigen (p55) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD4mut ^²

Descriptions
CD4 antigen ^², ³
CD4 antigen (p55) ^¹, ²
CD4 molecule ^²
CD4 receptor ^²
T-cell surface antigen T4/Leu-3 ^³

External Ids
HGNC: 1678¹
Entrez Gene: 920²
UniProtKB: P01730³
Ensembl: ENSG00000010610⁷

Search outside databases for aliases for CD4 gene

Previous GC identifers: GC12M007045 GC12M007130 GC12P006777

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CD4_HUMAN, P01730

Function: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate

T-cell activation. Induces the aggregation of lipid rafts

Gene Wiki entry for CD4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CD4 gene

Entrez Gene cytogenetic band: 12pter-p12 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12pter-p12

CD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P006769: (about GC identifiers)

Start:	6,768,912 bp from pter
End:	6,800,237 bp from pter
Size:	31,326 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009759.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CD4_HUMAN, P01730 (See protein sequence)

Recommended Name: T-cell surface glycoprotein CD4 precursor

Size: 458 amino acids; 51111 Da

Subunit: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the

cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope

polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid

rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent

endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also

down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the

endoplasmic reticulum

Miscellaneous: Primary receptor for HIV-1

PDB structures from and Proteopedia :

1CDH (3D)

1CDI (3D)

1CDJ (3D)

1CDU (3D)

1CDY (3D)

1G9M (3D)

1G9N (3D)

1GC1 (3D)

1JL4 (3D)

1OPN (3D)

1OPT (3D)

1OPW (3D)

1Q68 (3D)

1RZJ (3D)

1RZK (3D)

1WBR (3D)

1WIO (3D)

1WIP (3D)

1WIQ (3D)

2B4C (3D)

2JKR (3D)

2JKT (3D)

2NXY (3D)

2NXZ (3D)

2NY0 (3D)

2NY1 (3D)

2NY2 (3D)

2NY3 (3D)

2NY4 (3D)

2NY5 (3D)

2NY6 (3D)

2QAD (3D)

3B71 (3D)

3CD4 (3D)

Secondary accessions: Q4ZGK2 Q5U066

Post-translational modifications:

Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000607.1

ENSEMBL proteins:

ENSP00000011653

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CD4
	R&D Systems Recombinant & Natural Proteins for CD4
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Basophils + CD4 + T Lymphocyte subpopulation, CD3 + CD4 + CD45, CD4 + HLA DR, CD4 + CD62L, CD3 + CD4 + CD8, CD4 + CD25, CD45RA + CD4, CD4 + HLA Class II, CD4 + CD45RO, CD2 + CD4, CD3 + CD4, CD4, CD4 + CD8)
	Human Recombinant Proteins from Abnova (CD4)

OriGene Purified Recombinant Human Protein: CD4

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005769	early endosome	EXP	2014052 15202998
GO:0005789	endoplasmic reticulum membrane	EXP	9660940
GO:0005886	plasma membrane	IDA	8124721
GO:0009897	external side of plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for CD4:

	Invitrogen Antibodies for CD4
	Millipore Mono- and Polyclonal Antibodies for the study of CD4
	Sigma-Aldrich Antibodies for CD4
	R&D Systems Antibodies for CD4
	Cell Signaling Technology (CST) Antibodies for CD4
	Antibodies from Abcam (Basophils + CD4 + T Lymphocyte subpopulation, CD3 + CD4 + CD45, CD4 + HLA DR, CD4 + CD62L, CD3 + CD4 + CD8, CD4 + CD25, CD45RA + CD4, CD4 + HLA Class II, CD4 + CD45RO, CD2 + CD4, CD3 + CD4, CD4, CD4 + CD8), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CD4)
	Novus Biologicals Antibodies for CD4

Assays for CD4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01730

ProtoNet protein and cluster: P01730

3 Blocks protein families:

IPB000973 T-cell surface glycoprotein CD4 signature

IPB003596 Immunoglobulin V-type

IPB008424 T-cell surface antigen CD2

UniProtKB/Swiss-Prot: CD4_HUMAN, P01730

Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000616

Applied Biosystems Silencer® siRNAs for CD4

Sigma-Aldrich siRNA and siRNA Panels for CD4

Sigma-Aldrich shRNA Panels and shRNA for CD4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CD4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000616
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000616
untagged cDNA clone in CMV expression vector: NM_000616

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000616

UniProtKB/Swiss-Prot: CD4_HUMAN, P01730

Function: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate

T-cell activation. Induces the aggregation of lipid rafts

Genatlas biochemistry entry for CD4:

cell differentiation antigen CD4 (p55),59kDa,HIV & MHC class II receptor,identified by monoclonal

antibodies T4,Leu-3a,91D6,transmembrane glycoprotein (see LAG3),containing a tissue-specific

promoter made of an initiator-like sequence,an ETS and an ATF consensus site, and a locus control

region like,see LCR-CD4

9 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Cd4):

digestive/alimentary	hematopoietic system	homeostasis/metabolism	immune system	life span-post-weaning/aging
nervous system	no phenotypic analysis	normal	skin/coat/nails

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001948	glycoprotein binding	IPI	10922058
GO:0004888	transmembrane receptor activity	TAS	10358157
GO:0005201	extracellular matrix structural constituent	NAS	12444132
GO:0008270	zinc ion binding	IDA	9668045
GO:0015026	coreceptor activity	NAS	8512039

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for CD4 (Your Favorite Gene powered by Ingenuity) (see all 9 )

NF-&kappa
T Cell Receptor Signaling
CD28 Signaling in T Helper Cells
CXCR4 Signaling
CTLA4 Signaling in Cytotoxic T Lymphocytes

GeneDecks CD4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CD4

5/327 Interacting proteins for CD4 (P01730² ENSP00000011653³) via UniProtKB, MINT, and/or STRING (see all 327 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LCK	P06239², ENSP00000328213³	MINT-3375588 MINT-3373991 MINT-66002 STRING (score=.999)
HLA-C	ENSP00000365412³	STRING (score=.958) STRING (score=.817)
NR3C1	P04150²	MINT-3373972 MINT-3373954
CCR5	ENSP00000292303³	STRING (score=.999)
CD28	ENSP00000324890³	STRING (score=.999)

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000747	conjugation with cellular fusion	IDA	9166430
GO:0001816	cytokine production	IEA	--
GO:0006955	immune response	NAS	8512039
GO:0007155	cell adhesion	IEA	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	NAS	8512039

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CD4
10/36 Novoseek chemical compound relationships for CD4 gene (see all 36 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
c-d4i	76.16	6	12208966 (3), 12487827 (2)
aurintricarboxylic acid	67.87	3	1691563 (1), 1704066 (1), 1979910 (1)
rantes	54.20	5	17015796 (1), 10649782 (1), 11064099 (1), 9311806 (1) (see all 5)
galactosylceramide	52.39	6	12586555 (2), 11201521 (1), 12709027 (1), 11262202 (1)
prostratin	51.55	8	15457682 (5), 11698284 (1)
mdms	48.27	5	11920312 (3), 10445810 (1)
tyrosine	41.04	58	2040625 (3), 1532148 (3), 9117451 (2), 1834739 (2) (see all 32)
tarc	32.80	3	15805991 (3)
phorbol	30.55	5	8627671 (1), 7545243 (1), 2292458 (1), 1612121 (1) (see all 5)
glycosphingolipid	30.38	3	10864648 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000616

Sigma-Aldrich siRNA and siRNA Panels for CD4

Sigma-Aldrich shRNA Panels and shRNA for CD4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000616

REFSEQ mRNAs for CD4 gene:

NM_000616.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000616

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000616
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000616
                                 untagged cDNA clone in CMV expression vector: NM_000616

Additional cDNA sequence:

AK300052.1 AK303968.1 AK308344.1 AK310652.1 AK310677.1 AK310687.1 AK310750.1 AK311495.1

AK312828.1 AK315898.1 AK316461.1 AK316462.1 BC025782.1 BT019791.1 BT019811.1 M12807.1

S79267.1 U40625.1

24/27 DOTS entries (see all 27 ):

DT.121200495 DT.121200491 DT.95220970 DT.99926928 DT.100770953 DT.121200507 DT.121200514 DT.121200496

DT.102841595 DT.121200541 DT.121200492 DT.121200398 DT.121200534 DT.121200502 DT.121200538 DT.121200551

DT.91693171 DT.92018945 DT.100771947 DT.102841604 DT.102841608 DT.121200402 DT.121200493 DT.121200539

4 AceView cDNA sequences:

BC025782 NM_000616 M12807 U40625

highest scoring ESTs for CD4:

M12807 AW881568 AW881587 BC025782 AA522699 AF391803 AW451254 AW608423 AW839529 BE242116

Unigene Cluster for CD4:

CD4 molecule

Hs.631659 [show with all ESTs]

Unigene Representative Sequence: S79267

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CD4 (see all 13 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^
SP1:									-		-		-		-										-						-		-		-														-		-
SP2:									-		-
SP3:									-		-		-		-										-
SP4:									-		-				-
SP5:													-		-

ExUns:	14	^	15a	·	15b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CD4

1 Ensembl transcript including schematic representation:

ENST00000011653

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CD4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CD4

¹ / ² / ³

8 probe-sets matching CD4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
856_at²^{, 3}	U95-A	1	1.00	1.00	0.33	0.71	S79267	0.40	1.00	0.76	1
1146_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.81	HG3477-HT3670	0.20	1.00	0.72	1
48538_at²^{, 3}	U95-B	1	1.00	1.00	0.93	1.59	AA522699	0.60	1.00	0.82	1
35517_at²^{, 3}	U95-A	1	0.94	1.00	0.93	0.92	M12807	1.00	1.00	1.00	1
216424_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S79267	0.40	1.00	0.76	1
203547_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
216424_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203547_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CD4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGAAGGGTCC

SOURCE GeneReport for Unigene cluster: Hs.631659
Expression variation in blood from EXPOLDB for CD4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CD4 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CD4¹	--	CD4 molecule	73.72(n) 61.25(a)	403931 XM_850488.1 XP_855581.1
chimpanzee (Pan troglodytes)	CD4¹	--	CD4 molecule	99.13(n) 98.91(a)	450124 NM_001009043.1 NP_001009043.1
cow (Bos taurus)	CD4¹	--	CD4 molecule	73.06(n) 61.85(a)	407098 XM_588150.3 XP_588150.3
rat (Rattus norvegicus)	Cd4¹	--	Cd4 molecule	68.75(n) 55.23(a)	24932 NM_012705.1 NP_036837.1
mouse (Mus musculus)	Cd4^{1, 5}	6 (60.18 cM)⁵	CD4 antigen^{1, 5}	69(n)¹ 56.33(a)¹	12504¹ NM_013488.2¹ NP_038516.1¹ AC002397⁵ AF045882⁵ (see all 22)

About this table Species with no ortholog for CD4

ENSEMBL Gene Tree for CD4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/406 NCBI SNPs in CD4 are shown (see all 406 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 162)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11064391^1,2	A,C,F,H	6767788(+)	`ACTAGC/AGTTTT`	1	--	ng5¹		8	EU EA WA	838
	rs3213427^1,2	A,C,F,H	6799008(+)	`CTCATT/CATTTC`	1	--	ut3¹		13	EA NS EU NA	2348
	rs7956804^1,2	A,C,F,H	6768721(+)	`ATGGCA/GCTACC`	1	--	ng5¹		21	NA NS EA EU WA	1632
	rs2855534^1,2	A,C,F,H	6768782(+)	`TGACAG/CTTTGA`	1	--	ng5¹		19	EA EU NA MN WA	4844
--	rs11064419^1,2	C,F,H	6795555(+)	`CGCCTT/CTACAG`	1	S/F	mis¹ ese³		9	EU EA WA NS	586
	rs11064392^1,2	C,F,H	6768653(+)	`GGCTTA/GCCACT`	1	--	ng5¹		13	EU EA WA NS	962
--	rs2515733^1,2	A,C,F	6767913(+)	`GATCCT/CCCCAC`	1	--	ng5¹		6	EU NS	1084
	rs3213429^1,2	C,F	6799174(+)	`TGCACA/GAAATC`	1	--	ut3¹		10	NS MN CSAM EA	594
--	rs4646959^1,2	C,F	6768442(+)	`AGATTC/G/TGGGCT`	1	--	ng5¹		6	EU NS	1086
	rs28917504^1,2	C,F	6794383(+)	`ACCAGA/GAGAAG`	1	K/E	mis¹ ese³		6	NS NA	264

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HapMap Linkage Disequilibrium images for CD4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 186940

10/54 Novoseek disease relationships for CD4 gene (see all 54 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	86.93	288	1975594 (4), 9367961 (4), 2040625 (3), 7521692 (3) (see all 99)
hiv infections	69.74	50	1706342 (3), 1983967 (2), 1674171 (2), 11689637 (2) (see all 39)
aids	57.04	28	7691271 (2), 2297204 (2), 1774603 (2), 2184372 (1) (see all 20)
virus infection	55.73	18	1975594 (2), 1983967 (1), 1939640 (1), 15540608 (1) (see all 16)
antibody-dependent enhancement	44.25	4	1976824 (2), 16987062 (2)
superinfection	37.79	5	16873261 (3), 7474070 (1), 8005387 (1)
anaplastic large cell lymphoma	36.42	2	17430665 (1)
aids-related complex	33.57	3	2297204 (2), 1774603 (1)
vesicular stomatitis	30.91	2	11704677 (1), 1310767 (1)
leukemia t-cell	28.95	1	1532148 (1)

About this table

Genetic Association Database: CD4
Human Genome Epidemiology Navigator: CD4 (180 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1433 PubMed articles for CD4 gene (see all 1433 ):

Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. (PubMed id 12517957)^{1, 3, 4} Fragoso R.... Jin Y.J. (2003)
Protein minimization of the gp120 binding region of human CD4. (PubMed id 16331979)^{3, 4} Sharma D.... Varadarajan R. (2005)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
Molecular genetic analysis of TPO and CD4 loci among two endogamous ethnic groups of Maharashtra in Western India. (PubMed id 15317218)^{3, 6} Das B. and Seshadri M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{3, 6} Saito T....Kawata S. (2004)
CD4 and major histocompatibility complex class I downregulation by the human immunodeficiency virus type 1 nef protein in pediatric AIDS progression. (PubMed id 14557639)^{3, 6} Casartelli N....Doria M. (2003)
Cloning of ACP33 as a novel intracellular ligand of CD4. (PubMed id 11113139)^{3, 4} Zeitlmann L.... Kolanus W. (2001)
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. (PubMed id 9641677)^{3, 4} Kwong P.D....Hendrickson W.A. (1998)
Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PubMed id 9074930)^{3, 4} Ansari-Lari M.A....Gibbs R.A. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 920	HGNC: 1678	AceView: CD4	Ensembl:ENSG00000010610	euGenes: HUgn920
ECgene: CD4	H-InvDB: CD4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CD4	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cd4/
Wikipedia	http://en.wikipedia.org/wiki/CD4

Licensable Technologies for CD4
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for CD4 gene:

Salk Institute:

Alpha-Complementation Viral Fusion Assay

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CD4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CD4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CD4		Antibodies for CD4
	Explore super-pooled esiRNAs		Proteins for CD4
	Lentivirus-delivered shRNAs for CD4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CD4)
	Antibodies (CD4)
	Chimera RNAi (CD4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CD4

	Recombinant Proteins (Basophils + CD4 + T Lymphocyte subpopulation, CD3 + CD4 + CD45, CD4 + HLA DR, CD4 + CD62L, CD3 + CD4 + CD8, CD4 + CD25, CD45RA + CD4, CD4 + HLA Class II, CD4 + CD45RO, CD2 + CD4, CD3 + CD4, CD4, CD4 + CD8)
	Antibodies (Basophils + CD4 + T Lymphocyte subpopulation, CD3 + CD4 + CD45, CD4 + HLA DR, CD4 + CD62L, CD3 + CD4 + CD8, CD4 + CD25, CD45RA + CD4, CD4 + HLA Class II, CD4 + CD45RO, CD2 + CD4, CD3 + CD4, CD4, CD4 + CD8)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CD4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CD4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CD4 Gene at Home site.
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CD4 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for CD4

Summaries
for CD4

Genomic Location
for CD4

Proteins
for CD4

Protein Domains/
Families
for CD4

Gene Function
for CD4

Pathways & Interactions
for CD4

Drugs & Compounds
for CD4

Transcripts
for CD4

Expression
for CD4

Orthologs
for CD4

Paralogs
for CD4

SNPs/Variants
for CD4

Disorders & Mutations
for CD4

Medical News
for CD4

Publications
for CD4

Search for CD4

Genome Databases showing CD4

Other Databases showing CD4

Specialized Databases showing CD4

Licensable Technologies
for CD4

Services
for CD4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CD4 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor CD4

Summariesfor CD4

Genomic Locationfor CD4

Proteinsfor CD4

Protein Domains/Familiesfor CD4

Gene Functionfor CD4

Pathways & Interactionsfor CD4

Drugs & Compoundsfor CD4

Transcriptsfor CD4

Expression for CD4

Orthologsfor CD4

Paralogsfor CD4

SNPs/Variantsfor CD4

Disorders & Mutationsfor CD4

Medical Newsfor CD4

Publicationsfor CD4

Search for CD4

Genome Databases showing CD4

Other Databases showing CD4

Specialized Databases showing CD4

Licensable Technologiesfor CD4

Servicesfor CD4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CD4

Summaries
for CD4

Genomic Location
for CD4

Proteins
for CD4

Protein Domains/
Families
for CD4

Gene Function
for CD4

Pathways & Interactions
for CD4

Drugs & Compounds
for CD4

Transcripts
for CD4

Expression
for CD4

Orthologs
for CD4

Paralogs
for CD4

SNPs/Variants
for CD4

Disorders & Mutations
for CD4

Medical News
for CD4

Publications
for CD4

Licensable Technologies
for CD4

Services
for CD4