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Aliases for CD4 Gene

Aliases for CD4 Gene

  • CD4 Molecule 2 3 5
  • T-Cell Surface Glycoprotein CD4 2 3
  • T-Cell Surface Antigen T4/Leu-3 3 4
  • CD4 Antigen (P55) 2 3
  • CD4 Receptor 3
  • CD4 Antigen 4
  • CD4mut 3

External Ids for CD4 Gene

Previous GeneCards Identifiers for CD4 Gene

  • GC12M007045
  • GC12M007130
  • GC12P006777
  • GC12P006769
  • GC12P006899

Summaries for CD4 Gene

Entrez Gene Summary for CD4 Gene

  • This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for CD4 Gene

CD4 (CD4 Molecule) is a Protein Coding gene. Diseases associated with CD4 include Okt4 Epitope Deficiency and Ventilation Pneumonitis. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include protein homodimerization activity and enzyme binding.

UniProtKB/Swiss-Prot for CD4 Gene

  • Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

  • (Microbial infection) Acts as a receptor for human immunodeficiency virus-1 (PubMed:2214026, PubMed:16331979, PubMed:9641677). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).

Gene Wiki entry for CD4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD4 Gene

Genomics for CD4 Gene

Regulatory Elements for CD4 Gene

Enhancers for CD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G006788 1.5 FANTOM5 ENCODE dbSUPER 21.3 +4.2 4219 5.0 HDGF FOXA2 PKNOX1 MLX ARID4B ZNF48 YY1 SLC30A9 ZNF121 SP5 CD4 LPAR5 GPR162 P3H3 PTPN6 ING4 PTMS MLF2 GNB3 PIANP
GH12G006784 1.2 Ensembl ENCODE dbSUPER 16.9 -0.9 -944 3.3 HLF MAFG ZNF223 KAT2B ZFHX2 ZNF316 MAFF ZNF341 ZSCAN5C CUX1 CD4 GPR162 P3H3 ZNF384 ENSG00000219410 ING4 ACRBP PIANP LPAR5 GAPDH
GH12G006722 1.2 ENCODE 11.7 -62.8 -62806 2.3 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 ENSG00000219410 ZNF384 CD4 GPR162 P3H3 ING4 ACRBP LPAR5 CHD4 NOP2
GH12G006735 1.1 Ensembl ENCODE 11.6 -51.0 -51011 1.1 INSM2 ARID4B RAD21 YY1 ZNF121 SCRT2 MIXL1 ZNF654 ZEB2 REST PTMS MLF2 LAG3 CD4 GPR162 P3H3 ING4 ENSG00000219410 ACRBP CHD4
GH12G006880 0.9 ENCODE 10.8 +94.0 94014 1.6 ZFP64 ARID4B DMAP1 ZNF202 REST ZNF623 ZNF518A ZNF292 MIER3 ZBTB21 SPSB2 ENSG00000219410 C12orf57 GNB3 PHB2 ENSG00000247853 ENO2 USP5 CDCA3 ATN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD4 Gene

Chromosome:
12
Start:
6,786,858 bp from pter
End:
6,820,810 bp from pter
Size:
33,953 bases
Orientation:
Plus strand

Genomic View for CD4 Gene

Genes around CD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD4 Gene

Proteins for CD4 Gene

  • Protein details for CD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01730-CD4_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD4
    Protein Accession:
    P01730
    Secondary Accessions:
    • B2R737
    • D3DUS5
    • Q4ZGK2
    • Q5U066
    • Q9UDE5

    Protein attributes for CD4 Gene

    Size:
    458 amino acids
    Molecular mass:
    51111 Da
    Quaternary structure:
    • Associates with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI.
    • (Microbial infection) Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu (PubMed:2214026, PubMed:16331979, PubMed:9641677).
    • (Microbial infection) Interacts with Human Herpes virus 7 surface proteins.
    Miscellaneous:
    • Primary receptor for HIV-1.

    Three dimensional structures from OCA and Proteopedia for CD4 Gene

neXtProt entry for CD4 Gene

Post-translational modifications for CD4 Gene

  • Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
  • Ubiquitination at posLast=453453
  • Glycosylation at posLast=296296 and Asn325
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CD4 Gene

Domains & Families for CD4 Gene

Suggested Antigen Peptide Sequences for CD4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD4: view

No data available for UniProtKB/Swiss-Prot for CD4 Gene

Function for CD4 Gene

Molecular function for CD4 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD4 (p55),59kDa,HIV & MHC class II receptor,identified by monoclonal antibodies T4,Leu-3a,91D6,transmembrane glycoprotein (see LAG3),containing a tissue-specific promoter made of an initiator-like sequence,an ETS and an ATF consensus site, and a locus control region like,see LCR-CD4
UniProtKB/Swiss-Prot Function:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human immunodeficiency virus-1 (PubMed:2214026, PubMed:16331979, PubMed:9641677). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).

Gene Ontology (GO) - Molecular Function for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001948 glycoprotein binding IPI 10922058
GO:0004872 receptor activity TAS 10413516
GO:0004888 transmembrane signaling receptor activity TAS 10358157
GO:0005201 extracellular matrix structural constituent NAS 12444132
genes like me logo Genes that share ontologies with CD4: view
genes like me logo Genes that share phenotypes with CD4: view

Human Phenotype Ontology for CD4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD4 Gene

MGI Knock Outs for CD4:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD4 Gene

Localization for CD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD4 Gene

Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD4 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
endosome 4
extracellular 2
peroxisome 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome TAS --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 24942581
genes like me logo Genes that share ontologies with CD4: view

Pathways & Interactions for CD4 Gene

genes like me logo Genes that share pathways with CD4: view

Gene Ontology (GO) - Biological Process for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 24942581
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006948 induction by virus of host cell-cell fusion IDA 9166430
genes like me logo Genes that share ontologies with CD4: view

No data available for SIGNOR curated interactions for CD4 Gene

Drugs & Compounds for CD4 Gene

(137) Drugs for CD4 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Primaquine Approved Pharma 76
Zidovudine Approved Pharma 495
Anti-thymocyte Globulin (Rabbit) Approved Pharma Target 0
Abacavir Approved, Investigational Pharma 214
Atovaquone Approved Pharma 40

(34) Additional Compounds for CD4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for CD4 Gene

Compound Action Cas Number
BMS-378806 Gp120/CD4 inhibitor 357263-13-9
YYA-021 Competitive gp120-CD4 interaction inhibitor 144217-65-2
genes like me logo Genes that share compounds with CD4: view

Transcripts for CD4 Gene

mRNA/cDNA for CD4 Gene

(6) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD4 Gene

CD4 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: -
SP12: -
SP13:

ExUns: 14 ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CD4 Gene

GeneLoc Exon Structure for
CD4
ECgene alternative splicing isoforms for
CD4

Expression for CD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD4 Gene

This gene is overexpressed in Spleen (x8.4) and Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for CD4 Gene

This gene is overexpressed in Lymph node (26.9), Tlymphocyte (15.4), Peripheral blood mononuclear cells (13.9), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD4 Gene



Protein tissue co-expression partners for CD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD4 Gene:

CD4

SOURCE GeneReport for Unigene cluster for CD4 Gene:

Hs.631659

Evidence on tissue expression from TISSUES for CD4 Gene

  • Blood(4.7)
  • Nervous system(4.7)
  • Liver(4.5)
  • Pancreas(4.1)
  • Spleen(3.4)
  • Kidney(3.1)
  • Lung(2.9)
  • Lymph node(2.8)
  • Intestine(2.4)
  • Bone marrow(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD4 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
Organs:
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with CD4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CD4 Gene

Orthologs for CD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD4 34 35
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia CD4 34
  • 74.68 (n)
cow
(Bos Taurus)
Mammalia CD4 34 35
  • 72.34 (n)
mouse
(Mus musculus)
Mammalia Cd4 34 16 35
  • 69.48 (n)
rat
(Rattus norvegicus)
Mammalia Cd4 34
  • 68.67 (n)
oppossum
(Monodelphis domestica)
Mammalia CD4 35
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD4 35
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD4 34 35
  • 43.76 (n)
Species where no ortholog for CD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD4 Gene

ENSEMBL:
Gene Tree for CD4 (if available)
TreeFam:
Gene Tree for CD4 (if available)

Paralogs for CD4 Gene

No data available for Paralogs for CD4 Gene

Variants for CD4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD4 Gene

CD4_HUMAN-P01730
The OKT monoclonal antibodies are widely used for the analysis of human peripheral blood T-lymphocytes. OKT4 reacts with T-helper/inducer lymphocytes. The OKT4 epitope of the CD4 cell-surface protein is polymorphic in white, black, and Japanese populations. The variable phenotypic expression is due a CD4 polymorphism. OKT4 positive individuals carry Arg-265 and OKT4 negative individuals carry Trp-265 [MIM:613949].

Sequence variations from dbSNP and Humsavar for CD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs28919570 Pathogenic 6,816,241(+) TAAAA(C/T)GGGTT reference, missense, utr-variant-5-prime
rs1000078109 -- 6,790,490(+) TTGCA(C/G)ATACA intron-variant
rs1000166755 -- 6,787,857(+) GGCGG(A/G)GGTTG upstream-variant-2KB
rs1000457374 -- 6,793,088(+) GGGAC(G/T)CTGAG intron-variant
rs1000481071 -- 6,815,177(+) CTGAT(C/T)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD4 Gene

Variant ID Type Subtype PubMed ID
dgv2323n54 CNV loss 21841781
dgv757n106 CNV deletion 24896259
esv2663865 CNV deletion 23128226
esv2745479 CNV deletion 23290073
esv3548686 CNV deletion 23714750
esv3548687 CNV deletion 23714750
nsv1069635 CNV deletion 25765185
nsv1127245 CNV deletion 24896259
nsv1152779 CNV deletion 26484159
nsv52513 CNV deletion 16902084
nsv593 CNV deletion 18451855
nsv832323 CNV loss 17160897
nsv832324 CNV loss 17160897
nsv957248 CNV deletion 24416366

Variation tolerance for CD4 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD4 Gene

Human Gene Mutation Database (HGMD)
CD4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD4

Disorders for CD4 Gene

MalaCards: The human disease database

(169) MalaCards diseases for CD4 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
okt4 epitope deficiency
ventilation pneumonitis
  • air-conditioner and humidifier lung
pneumocystosis
  • pneumocystis carinii pneumonia
hiv-1
  • aids, slow progression to
idiopathic cd4-positive t-lymphocytopenia
  • immunodeficiency 13
- elite association - COSMIC cancer census association via MalaCards
Search CD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD4

Genetic Association Database (GAD)
CD4
Human Genome Epidemiology (HuGE) Navigator
CD4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD4
genes like me logo Genes that share disorders with CD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD4 Gene

Publications for CD4 Gene

  1. Structural basis for the interaction between focal adhesion kinase and CD4. (PMID: 18078954) Garron M.L. … Arold S.T. (J. Mol. Biol. 2008) 3 4 22 64
  2. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. (PMID: 12517957) Fragoso R. … Jin Y.J. (J. Immunol. 2003) 3 4 22 64
  3. CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. (PMID: 20924289) Hennig B.J. … Sirugo G. (J. Acquir. Immune Defic. Syndr. 2011) 3 46 64
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  5. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee K.M. … Lan Q. (Am. J. Hematol. 2010) 3 46 64

Products for CD4 Gene

  • Addgene plasmids for CD4

Sources for CD4 Gene