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CD3G Gene

protein-coding   GIFtS: 66
GCID: GC11P118248

CD3g Molecule, Gamma (CD3-TCR Complex)

(Previous names: CD3g antigen, gamma polypeptide (TiT3 complex))
  See CD3G-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD3g Molecule, Gamma (CD3-TCR Complex)1 2     CD3-GAMMA2
CD3g Antigen, Gamma Polypeptide (TiT3 Complex)1 2     CD3g Molecule, Epsilon (CD3-TCR Complex)2
T3G2 3     T-Cell Antigen Receptor Complex, Gamma Subunit Of T32
T-Cell Receptor T3 Gamma Chain2 3     T-Cell Surface Glycoprotein CD3 Gamma Chain2
IMD172 5     CD3g Antigen3

External Ids:    HGNC: 16751   Entrez Gene: 9172   Ensembl: ENSG000001606547   OMIM: 1867405   UniProtKB: P096933   

Export aliases for CD3G gene to outside databases

Previous GC identifers: GC11P120571 GC11P119726 GC11P117752 GC11P117720 GC11P114148


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD3G Gene:
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta,
and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This
complex plays an important role in coupling antigen recognition to several intracellular signal-transduction
pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on
chromosome 11. Defects in this gene are associated with T cell immunodeficiency. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD3G Gene:
CD3G (CD3g molecule, gamma (CD3-TCR complex)) is a protein-coding gene. Diseases associated with CD3G include enteropathy-associated t-cell lymphoma, and immunodeficiency due to defect in cd3-gamma. GO annotations related to this gene include receptor signaling complex scaffold activity and protein heterodimerization activity. An important paralog of this gene is CD3D.

UniProtKB/Swiss-Prot: CD3G_HUMAN, P09693
Function: The CD3 complex mediates signal transduction

Gene Wiki entry for CD3G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD3G gene promoter:
         TBP   RP58   HSF2   TFIID   POU3F2   YY1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD3G promoter sequence
   Search Chromatin IP Primers for CD3G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD3G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23

CD3G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD3G gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118248:  view genomic region     (about GC identifiers)

Start:
118,215,059 bp from pter      End:
118,225,876 bp from pter
Size:
10,818 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD3G_HUMAN, P09693 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD3 gamma chain precursor  
Size: 182 amino acids; 20469 Da
Subunit: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer
coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta
1 PDB 3D structure from and Proteopedia for CD3G:
1SY6 (3D)    
Secondary accessions: Q2HIZ6

Explore the universe of human proteins at neXtProt for CD3G: NX_P09693

Explore proteomics data for CD3G at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32, Lys79, Lys93, Lys95, Lys150, Lys164
  • Glycosylation2 at Asn52, Asn92
  • Modification sites at PhosphoSitePlus

  • See CD3G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000064.1  
    ENSEMBL proteins: 
     ENSP00000431445   ENSP00000292144   ENSP00000376621  
    Reactome Protein details: P09693

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR015484 CD3_gsu/dsu
     IPR013783 Ig-like_fold
     IPR003110 Phos_immunorcpt_sig_ITAM

    Graphical View of Domain Structure for InterPro Entry P09693

    ProtoNet protein and cluster: P09693

    2 Blocks protein domains:
    IPB003110 Phosphorylated immunoreceptor signaling ITAM
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: CD3G_HUMAN, P09693
    Domain: A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and
    delivery to lysosomes
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 ITAM domain


    Find genes that share domains with CD3G           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD3G_HUMAN, P09693
    Function: The CD3 complex mediates signal transduction

         Genatlas biochemistry entry for CD3G:
    cell differentiation antigen CD3G (gp26),,gamma polypeptide (see CD3@),including an alternative splicing product
    pTAC12,component of the pre-T cell antigen receptor complex

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity IMP12794121
    GO:0005515protein binding ----
    GO:0030159receptor signaling complex scaffold activity NAS12794121
    GO:0042608T cell receptor binding NAS11186279
    GO:0046982protein heterodimerization activity IPI9485181
         
    Find genes that share ontologies with CD3G           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cd3g):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with CD3G           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD3G: Cd3gtm2Amk Cd3gtm1Amk Cd3d/Cd3gCd3d/tm1Cpt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD3G
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    miRNA
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    hsa-miR-3690 hsa-miR-136 hsa-miR-2909 hsa-miR-619 hsa-miR-519e* hsa-miR-378b hsa-miR-422a hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD3G 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CD3G
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD3G_HUMAN, P09693: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    extracellular2
    golgi apparatus2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS9485181
    GO:0016020membrane ----
    GO:0042101T cell receptor complex NAS9485181
    GO:0042105alpha-beta T cell receptor complex IEA--

    Find genes that share ontologies with CD3G           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD3G About   (see all 38)  
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    T cell receptor signaling pathway0.38
    TCR Signaling Pathway0.36
    2IL12-mediated signaling events
    Immune response IL 12 induced IFN gamma production0.33
    IL12-mediated signaling events0.33
    3CD28 co-stimulation
    Costimulation by the CD28 family0.44
    CTLA4 Signaling0.30
    4Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.83
    PD-1 signaling0.72
    Phosphorylation of CD3 and TCR zeta chains0.83
    Generation of second messenger molecules0.62
    5Immune response NFAT in immune response
    Immune response NFAT in immune response0.55
    Immune response T cell receptor signaling pathway0.50
    Immune response ICOS pathway in T helper cell0.55
    Immune response CD28 signaling0.49


    Find genes that share SuperPaths with CD3G           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CD3G (see all 20)
        Calcium Mediated T-Cell Apoptosis
    Nur77 Signaling in T-Cell
    NFAT Signaling and Lymphocyte Interactions
    CTL Mediated Apoptosis
    Tec Kinases Signaling

    Selected GeneGo (Thomson Reuters) Pathways for CD3G (see all 13)
        G-protein signaling Regulation of RAC1 activity
    Immune response Antigen presentation by MHC class II
    Immune response CD28 signaling
    Immune response IL-12-induced IFN-gamma production
    G-protein signaling N-RAS regulation pathway

    Selected BioSystems Pathways for CD3G (see all 7)
        TCR Signaling Pathway
    IL12-mediated signaling events
    TCR signaling in naive CD4+ T cells
    IL12 signaling mediated by STAT4
    TCR signaling in naive CD8+ T cells


    Selected Reactome Pathways for CD3G (see all 9)
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    FCGR activation
    Translocation of ZAP-70 to Immunological synapse
    Regulation of actin dynamics for phagocytic cup formation
    Downstream TCR signaling


    5 Kegg Pathways  (Kegg details for CD3G):
        Hematopoietic cell lineage
    T cell receptor signaling pathway
    Chagas disease (American trypanosomiasis)
    Measles
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD3G: 
              Cell Surface Markers in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD3G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD3G (P096933 ENSP000002921444) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD3EP077663, ENSP000003545664I2D: score=3 STRING: ENSP00000354566
    CD3DP042343, ENSP000003006924I2D: score=1 STRING: ENSP00000300692
    SYKP434053, ENSP000003648984I2D: score=1 STRING: ENSP00000364898
    ZAP70P434033, ENSP000002649724I2D: score=1 STRING: ENSP00000264972
    B2MENSP000003408584STRING: ENSP00000340858
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly NAS12794121
    GO:0007163establishment or maintenance of cell polarity IMP12407027
    GO:0007166cell surface receptor signaling pathway IMP12407027
    GO:0015031protein transport IMP12794121
    GO:0031295T cell costimulation TAS--

    Find genes that share ontologies with CD3G           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD3G

    1 DrugBank Compound for CD3G    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MuromonabAntiCD3 (see all 2)140608-64-6target--2503348 8861551

    1 Novoseek inferred chemical compound relationship for CD3G gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 31 4 8845015 (1), 8647168 (1), 8700169 (1), 10212263 (1)



    Find genes that share compounds with CD3G           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD3G gene: 
    NM_000073.2  

    Unigene Cluster for CD3G:

    CD3g molecule, gamma (CD3-TCR complex)
    Hs.2259  [show with all ESTs]
    Unigene Representative Sequence: AK223314
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533462 ENST00000527777 ENST00000532917(uc001psu.2) ENST00000292144
    ENST00000528540 ENST00000532903(uc009zaa.1) ENST00000392883
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    hsa-miR-3690 hsa-miR-136 hsa-miR-2909 hsa-miR-619 hsa-miR-519e* hsa-miR-378b hsa-miR-422a hsa-miR-515-5p
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    Additional mRNA sequence: 

    AK223314.1 AK299997.1 AK310578.1 AK310622.1 AK313966.1 AK315895.1 BC069685.1 BC113830.1 
    X04145.1 X60492.1 

    7 DOTS entries:

    DT.312067  DT.92415781  DT.120728208  DT.95284627  DT.101977235  DT.120728216  DT.120728217 

    24 AceView cDNA sequences:

    AU122431 T66799 AW119224 BP367737 CD014062 BP367961 BX406128 BX105974 
    NM_000073 N55436 BC069685 T66800 AA683199 BI830811 AA912663 AU148011 
    N76809 AI354472 AI247462 CD522462 T28951 R06554 T90300 R06553 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD3G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTAAAGAT
    CD3G Expression
    About this image


    CD3G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Peripheral Blood
             Bone marrow-derived hematopoietic stem cells (family)
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
    CD3G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD3G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2259
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD3G: 
              Cell Surface Markers in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD3G gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd3g1 , 5 CD3 antigen, gamma polypeptide1, 5 79.56(n)1
    70.17(a)1
      9 (24.84 cM)5
    125021  NM_009850.21  NP_033980.11 
     449695725 
    chicken
    (Gallus gallus)
    Aves CD3D6
    Gallus gallus CD3d molecule, delta (CD3-TCR comple...
    41(a)
    1 → many
    24(5480466-5482943) ENSGALG00000007418
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    31(a)
    1 → many
    GL343767.1(93549-102143)


    ENSEMBL Gene Tree for CD3G (if available)
    TreeFam Gene Tree for CD3G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD3G gene
    CD3D2  
    1 SIMAP similar gene for CD3G using alignment to 6 protein entries:     CD3G_HUMAN (see all proteins):
    CD3D

    Find genes that share paralogs with CD3G           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD3G (see all 363)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048941991,2
    Cpathogenic1118078842(+) CTGACA/GTGGAA 2 M V mis10--------
    rs1503761371,2
    C--114148973(+) GCACA-/GGCT  
            
    GGCTG
    1 -- ut510--------
    rs37530591,2
    C,F--114155245(-) CCAACA/GGCAAG 2 A syn15Minor allele frequency- G:0.16NS NA EU 5917
    rs37530581,2,,4
    C,F,H--114155246(-) CCCAAC/AAGCAA 2 /V /F mis15Minor allele frequency- A:0.16NS NA EU 6029
    rs1384163271,2
    C--118076970(+) GTAGCC/TTTACC 1 -- us2k10--------
    rs1419024491,2
    C,F--118076978(+) ACCTTG/TCGAGA 1 -- us2k11Minor allele frequency- T:0.00NA 4550
    rs2020800991,2
    C--118077000(+) AGTACA/CAGGCC 1 -- us2k10--------
    rs2015399381,2
    C--118077037(+) CCCAGA/C/TGGAAC 1 -- us2k10--------
    rs2021497261,2
    C--118077038(+) CCAGCA/GGAACT 1 -- us2k10--------
    rs769748781,2
    C--118077176(+) TCTGCC/GGTTGA 1 -- us2k12Minor allele frequency- G:0.09WA 120

    HapMap Linkage Disequilibrium report for CD3G (118215059 - 118225876 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CD3G:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820176CNV Loss19587683

    Human Gene Mutation Database (HGMD): CD3G
    Locus Specific Mutation Databases (LSDB): CD3G

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186740   
    OMIM disorders: 615607  
    4 diseases for CD3G:    
    About MalaCards
    enteropathy-associated t-cell lymphoma    immunodeficiency due to defect in cd3-gamma    immunodeficiency 17, cd3 gamma deficient    t lymphocyte deficiency

    2 diseases from the University of Copenhagen DISEASES database for CD3G:
    Severe combined immunodeficiency     T lymphocyte deficiency

    Find genes that share disorders with CD3G           About GenesLikeMe

    1 Novoseek inferred disease relationship for CD3G gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 2.94 4 10233990 (1), 12374807 (1), 9189762 (1)

    Genatlas disease: CD3G
    immunodeficiency,severe,combined,defect in surface expression of T-cell receptor-CD3 complex and defective signal
    transduction,through the TCR

    Genetic Association Database (GAD): CD3G
    Human Genome Epidemiology (HuGE) Navigator: CD3G (4 documents)

    Export disorders for CD3G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD3G gene, integrated from 10 sources (see all 134):
    (articles sorted by number of sources associating them with CD3G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. (PubMed id 20478055)1, 4 Brophy K....McManus R. (BMC Med. Genet. 2010)
    2. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. (PubMed id 1535555)1, 2 Letourneur F. and Klausner R.D. (Cell 1992)
    5. Dephosphorylation of the human T lymphocyte CD3 antigen. (PubMed id 2540970)1, 2 Alexander D....Crumpton M.J. (Eur. J. Biochem. 1989)
    6. Physical linkage of three CD3 genes on human chromosome 11. (PubMed id 2826124)1, 2 Tunnacliffe A.... Rabbitts T.H. (EMBO J. 1987)
    7. The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation. (PubMed id 3112151)1, 2 Davies A.A....Crumpton M.J. (J. Biol. Chem. 1987)
    8. Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits. (PubMed id 2944745)1, 2 Krissansen G.W.... Crumpton M.J. (EMBO J. 1986)
    9. The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes. (PubMed id 1826255)1, 9 AlarcA^n B....Terhorst C. (EMBO J. 1991)
    10. Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing. (PubMed id 17822534)1, 9 Akl H....Willard-Gallo K.E. (Virol. J. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 917 HGNC: 1675 AceView: CD3G Ensembl:ENSG00000160654 euGenes: HUgn917
    ECgene: CD3G Kegg: 917 H-InvDB: CD3G

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD3G Pharmacogenomics, SNPs, Pathways
    CD3Gbasehttp://bioinf.uta.fi/CD3Gbase/
    Wikipedia http://en.wikipedia.org/wiki/CD3_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD3G gene:
    Search GeneIP for patents involving CD3G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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