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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD3G Gene

protein-coding GIFtS: 64
GCID: GC11P118248

CD3g molecule, gamma (CD3-TCR complex)

(Previous names: CD3g antigen, gamma polypeptide (TiT3 complex) )

Explore 19 diseases affiliated with
CD3G via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD3g Molecule, Gamma (CD3-TCR Complex)¹ ²		CD3g Molecule, Epsilon (CD3-TCR Complex)²
CD3g Antigen, Gamma Polypeptide (TiT3 Complex)¹ ²		T-Cell Antigen Receptor Complex, Gamma Subunit Of T3²
T3G² ³		T-Cell Surface Glycoprotein CD3 Gamma Chain²
T-Cell Receptor T3 Gamma Chain² ³		CD3g Antigen³
CD3-GAMMA²

External Ids:	HGNC: 1675¹	Entrez Gene: 917²	Ensembl: ENSG00000160654⁷	OMIM: 186740⁵	UniProtKB: P09693³

Export aliases for CD3G gene to outside databases

Previous GC identifers: GC11P120571 GC11P119726 GC11P117752 GC11P117720 GC11P114148

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD3G:

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and

the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays

an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes

encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this

gene are associated with T cell immunodeficiency. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD3G_HUMAN, P09693

Function: The CD3 complex mediates signal transduction

Gene Wiki entry for CD3G

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD3G gene promoter:
TBP RP58 HSF2 TFIID POU3F2 YY1 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD3G promoter sequence

Search SABiosciences Chromatin IP Primers for CD3G

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD3G

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23

CD3G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD3G gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P118248: view genomic region (about GC identifiers)

Start:	118,215,059 bp from pter	End:	118,225,876 bp from pter
Size:	10,818 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD3G_HUMAN, P09693 (See protein sequence)

Recommended Name: T-cell surface glycoprotein CD3 gamma chain precursor

Size: 182 amino acids; 20469 Da

Subunit: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer

coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta

Subcellular location: Membrane; Single-pass type I membrane protein

1 PDB 3D structure from and Proteopedia for CD3G:

1SY6 (3D)

Secondary accessions: Q2HIZ6

Explore the universe of human proteins at neXtProt for CD3G: NX_P09693

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09693

CD3G Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000064.1

ENSEMBL proteins:

ENSP00000431445 ENSP00000292144 ENSP00000376621

Reactome Protein details: P09693
Human Recombinant Protein Products:

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	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	9485181
GO:0016020	membrane	--	--
GO:0042101	T cell receptor complex	NAS	9485181
GO:0042105	alpha-beta T cell receptor complex	IEA	--

CD3G for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD3G for domains About GeneDecksing

4 InterPro domains/families:

IPR003598 Ig_sub2

IPR015484 CD3_gsu/dsu

IPR013783 Ig-like_fold

IPR003110 Phos_immunorcpt_sig_ITAM

Graphical View of Domain Structure for InterPro Entry P09693

ProtoNet protein and cluster: P09693

2 Blocks protein families:

IPB003110 Phosphorylated immunoreceptor signaling ITAM

IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: CD3G_HUMAN, P09693

Domain: A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and

delivery to lysosomes

Similarity: Contains 1 Ig-like (immunoglobulin-like) domain

Similarity: Contains 1 ITAM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD3G_HUMAN, P09693

Function: The CD3 complex mediates signal transduction

Genatlas biochemistry entry for CD3G:

cell differentiation antigen CD3G (gp26),,gamma polypeptide (see CD3@),including an alternative splicing product

pTAC12,component of the pre-T cell antigen receptor complex

miRNA Products:		OriGene 3'-UTR Clone: CD3G Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD3G
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CD3G (see all 13):
		hsa-miR-3690 hsa-miR-136 hsa-miR-2909 hsa-miR-619 hsa-miR-519e* hsa-miR-378b hsa-miR-422a hsa-miR-515-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CD3G 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD3G

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane signaling receptor activity	IMP	12794121
GO:0005515	protein binding	--	--
GO:0030159	receptor signaling complex scaffold activity	NAS	12794121
GO:0042608	T cell receptor binding	NAS	11186279
GO:0046982	protein heterodimerization activity	IPI	9485181

CD3G for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CD3G: Cd3g^tm2Amk Cd3g^tm1Amk Cd3d/Cd3g^Cd3d/tm1Cpt
     3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cd3g):

cellular

hematopoietic system

immune system

CD3G for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/40 super-pathways (see all 40) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translocation of ZAP-70 to Immunological synapse

	Translocation of ZAP-70 to Immunological synapse	1.00			PD-1 signaling	0.76
	Phosphorylation of CD3 and TCR zeta chains	0.85			Generation of second messenger molecules	0.64

Cleavage of Alpha-1-Microglobulin

	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts	0.66			Role of phospholipids in phagocytosis	0.53
	FCGR activation	0.65			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.30

Immune response IL-12-induced IFN-gamma production

	Immune response IL-12-induced IFN-gamma production	1.00			IL12-mediated signaling events	0.33
	Immune response_IL-12-induced IFN-gamma production	0.88

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

Regulation of actin dynamics for phagocytic cup formation

	Regulation of actin dynamics for phagocytic cup formation	1.00			Fcgamma receptor (FCGR) dependent phagocytosis	0.80
	Role of myosins in phagosome formation	0.80

Pathway sources
See GeneCards unified pathways
Show all pathways

5/13 EMD Millipore Pathways for CD3G (see all 13)

	Immune response Antigen presentation by MHC class II
	Signal transduction IP3 signaling
	Immune response NFAT in immune response
	Immune response Antigen presentation by MHC class I
	Immune response CD28 signaling

5/20 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD3G (see all 20)

	Calcium Mediated T-Cell Apoptosis
	Nur77 Signaling in T-Cell
	NFAT Signaling and Lymphocyte Interactions
	CTL Mediated Apoptosis
	Tec Kinases Signaling

5/13 GeneGo (Thomson Reuters) Pathways for CD3G (see all 13)

	G-protein signaling Regulation of RAC1 activity
	Immune response Antigen presentation by MHC class II
	Immune response CD28 signaling
	Immune response IL-12-induced IFN-gamma production
	G-protein signaling N-RAS regulation pathway

5/7 BioSystems Pathways for CD3G (see all 7)

	TCR Signaling Pathway
	CXCR4-mediated signaling events
	Downstream signaling in naive CD8+ T cells
	TCR signaling in naive CD8+ T cells
	IL12 signaling mediated by STAT4

5/17 Reactome Pathways for CD3G (see all 17)

	Role of myosins in phagosome formation
	Costimulation by the CD28 family
	FCGR activation
	PD-1 signaling
	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts

4 Kegg Pathways (Kegg details for CD3G):

	Hematopoietic cell lineage
	T cell receptor signaling pathway
	Chagas disease (American trypanosomiasis)
	Measles

CD3G for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD3G

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/74 Interacting proteins for CD3G (P09693³ ENSP00000292144⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 74)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD3E	P07766³, ENSP00000354566⁴	I2D: score=3 STRING: ENSP00000354566
CD3D	P04234³, ENSP00000300692⁴	I2D: score=1 STRING: ENSP00000300692
SYK	P43405³, ENSP00000364898⁴	I2D: score=1 STRING: ENSP00000364898
ZAP70	P43403³, ENSP00000264972⁴	I2D: score=1 STRING: ENSP00000264972
B2M	ENSP00000340858⁴	STRING: ENSP00000340858

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	NAS	12794121
GO:0007163	establishment or maintenance of cell polarity	IMP	12407027
GO:0007166	cell surface receptor signaling pathway	IMP	12407027
GO:0015031	protein transport	IMP	12794121
GO:0031295	T cell costimulation	TAS	--

CD3G for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD3G for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD3G

1 DrugBank Compound for CD3G About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Muromonab	AntiCD3 (see all 2)	140608-64-6	target	--	2503348 8861551

1 Novoseek chemical compound relationship for CD3G gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	31	4	8845015 (1), 8647168 (1), 8700169 (1), 10212263 (1)

Search CenterWatch for drugs/clinical trials and news about CD3G

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD3G gene:

NM_000073.2

Unigene Cluster for CD3G:

CD3g molecule, gamma (CD3-TCR complex)

Hs.2259 [show with all ESTs]

Unigene Representative Sequence: AK223314

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000533462 ENST00000527777 ENST00000532917(uc001psu.2) ENST00000292144

ENST00000528540 ENST00000532903(uc009zaa.1) ENST00000392883

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		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CD3G (see all 13):
		hsa-miR-3690 hsa-miR-136 hsa-miR-2909 hsa-miR-619 hsa-miR-519e* hsa-miR-378b hsa-miR-422a hsa-miR-515-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CD3G 3' UTR sequence

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Additional cDNA sequence:

AK223314.1 AK299997.1 AK310578.1 AK310622.1 AK313966.1 AK315895.1 BC069685.1 BC113830.1

X04145.1 X60492.1

7 DOTS entries:

DT.312067 DT.92415781 DT.120728208 DT.95284627 DT.101977235 DT.120728216 DT.120728217

24 AceView cDNA sequences:

AW119224 T66799 AU122431 CD014062 BP367961 BP367737 N55436 T66800

BX406128 BC069685 BX105974 NM_000073 AA683199 BI830811 AA912663 N76809

AU148011 AI354472 AI247462 CD522462 T28951 T90300 R06554 R06553

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD3G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTAAAGAT

About this image

CD3G expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CD3G Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD3G

SOURCE GeneReport for Unigene cluster: Hs.2259

SABiosciences Expression via Pathway-Focused PCR Arrays including CD3G:

Cell Surface Markers in human mouse rat

T-cell & B-cell Activation in human mouse rat

Hematopoiesis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD3G

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD3G gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd3g^{1 , 5}	CD3 antigen, gamma polypeptide^{1, 5}	79.56(n)¹ 70.17(a)¹		9 (24.84 cM)⁵ 12502¹ NM_009850.2¹ NP_033980.1¹ 44969572⁵
chicken (Gallus gallus)	Aves	CD3D⁶	CD3D antigen, delta polypeptide (TiT3 complex)	40(a)	1 → many	24(5602402-5604890)
lizard (Anolis carolinensis)	Reptilia	--	--	39(a)	1 → many	GL343767.1(99052-102137)

ENSEMBL Gene Tree for CD3G (if available)
TreeFam Gene Tree for CD3G (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD3G gene

CD3D²

1 SIMAP similar gene for CD3G using alignment to 6 protein entries: CD3G_HUMAN (see all proteins):

CD3D

CD3G for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104894199^1,2	C	pathogenic	119224980(+)	`CTGACA/GTGGAA`	2	M V	mis¹		0	--	--	--	--
rs143990986^1,2	C,F	--	114149068(+)	`CTCATC/GCTGGC`	2	I M	mis¹		1		NA	3904
rs181713283^1,2	C,	--	114149071(+)	`ATCCTA/GGCTAT`	2	L	syn¹		0	--	--	--	--
rs3212266^1,2	F	--	114149877(-)	`TGCATA/CCATTT`	1	--	int¹		1		NA	40
rs3212265^1,2	H,	--	114149900(-)	`TACTCT/CCTTGG`	1	--	int¹		5		NA NS EA	448
rs113258047^1,2	C,	--	114150000(+)	`CGGGAC/TGTGGC`	1	--	int¹		1		NA	2
rs55943772^1,2	C,	--	114150331(+)	`GCAACG/ATTACC`	1	--	int¹		2		WA	120
rs77273153^1,2	C,	--	114151088(+)	`TATGAA/CCTCTT`	1	--	int¹		2		WA	120
rs56262491^1,2		--	114151622(+)	`CATTCA/TTTCAA`	1	--	int¹		0	--	--	--	--
rs3181258^1,2	C,	--	114152374(-)	`TATGCA/TCCTGT`	1	--	int¹		2		NA	42

HapMap Linkage Disequilibrium report for CD3G (118215059 - 118225876 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CD3G
1 CNV: 58495
Human Gene Mutation Database (HGMD): CD3G

Locus Specific Mutation Databases (LSDB): CD3G

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD3G for disorders           About GeneDecksing

OMIM gene information: 186740    OMIM disorders: --

19 diseases for CD3G:    About MalaCards

enteropathy-associated t-cell lymphoma immunodeficiency severe combined immunodeficiency hypereosinophilic syndrome

combined immunodeficiency renal cell carcinoma chagas disease multiple myeloma

rheumatoid arthritis trypanosomiasis hepatitis b measles

t lymphocyte deficiency myeloma arthritis dermatitis

breast cancer hepatitis carcinoma

2 diseases from the University of Copenhagen DISEASES database for CD3G:

Severe combined immunodeficiency T lymphocyte deficiency

1 Novoseek disease relationship for CD3G gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	2.94	4	10233990 (1), 12374807 (1), 9189762 (1)

Genatlas disease: CD3G

immunodeficiency,severe,combined,defect in surface expression of T-cell receptor-CD3 complex and defective signal

transduction,through the TCR

Human Genome Epidemiology (HuGE) Navigator: CD3G (4 documents)

Export disorders for CD3G gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD3G gene, integrated from 9 sources (see all 131):
(articles sorted by number of sources associating them with CD3G)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. (PubMed id 1535555)^{1, 2} Letourneur F. and Klausner R.D. (1992)
Dephosphorylation of the human T lymphocyte CD3 antigen. (PubMed id 2540970)^{1, 2} Alexander D....Crumpton M.J. (1989)
Physical linkage of three CD3 genes on human chromosome 11. (PubMed id 2826124)^{1, 2} Tunnacliffe A.... Rabbitts T.H. (1987)
The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation. (PubMed id 3112151)^{1, 2} Davies A.A....Crumpton M.J. (1987)
Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits. (PubMed id 2944745)^{1, 2} Krissansen G.W.... Crumpton M.J. (1986)
The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes. (PubMed id 1826255)^{1, 9} Alarcon B....Terhorst C. (1991)
Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing. (PubMed id 17822534)^{1, 9} Akl H....Willard-Gallo K.E. (2007)
Transcriptional regulation of the human CD3 gamma gene: the TATA-less CD3 gamma promoter functions via an initiator and contiguous Sp-binding elements. (PubMed id 15879122)^{1, 9} Badran B.M....Willard-Gallo K.E. (2005)
Identification of three NFAT binding motifs in the 5'-upstream region of the human CD3gamma gene that differentially bind NFATc1, NFATc2, and NF-kappa B p50. (PubMed id 12374807)^{1, 9} Badran B.M....Willard-Gallo K.E. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 917	HGNC: 1675	AceView: CD3G	Ensembl:ENSG00000160654	euGenes: HUgn917
ECgene: CD3G	Kegg: 917	H-InvDB: CD3G

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD3G	Pharmacogenomics, SNPs, Pathways
CD3Gbase	http://bioinf.uta.fi/CD3Gbase/
Wikipedia	http://en.wikipedia.org/wiki/CD3_receptor

Intellectual Property for CD3G gene
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Patent Information for CD3G gene:
Search GeneIP for patents involving CD3G

GeneCards and IP:
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