Aliases for CD3G Gene
External Ids for CD3G Gene
Previous GeneCards Identifiers for CD3G Gene
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD3G Gene
CD3G (CD3g Molecule) is a Protein Coding gene. Diseases associated with CD3G include Immunodeficiency 17, Cd3 Gamma Deficient and Immunodeficiency Due To Defect In Cd3-Gamma. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and TCR Signaling (Qiagen). GO annotations related to this gene include protein heterodimerization activity and receptor signaling complex scaffold activity. An important paralog of this gene is CD3D.
UniProtKB/Swiss-Prot for CD3G Gene
The CD3 complex mediates signal transduction.