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Aliases for CD3G Gene

Aliases for CD3G Gene

  • CD3g Molecule, Gamma (CD3-TCR Complex) 2 3
  • CD3g Antigen, Gamma Polypeptide (TiT3 Complex) 2 3
  • T-Cell Receptor T3 Gamma Chain 3 4
  • IMD17 3 6
  • T3G 3 4
  • T-Cell Antigen Receptor Complex, Gamma Subunit Of T3 3
  • T-Cell Surface Glycoprotein CD3 Gamma Chain 3
  • CD3g Molecule, Epsilon (CD3-TCR Complex) 3
  • CD3g Antigen 4
  • CD3-GAMMA 3

External Ids for CD3G Gene

Previous GeneCards Identifiers for CD3G Gene

  • GC11P120571
  • GC11P119726
  • GC11P118248
  • GC11P117752
  • GC11P117720
  • GC11P114148

Summaries for CD3G Gene

Entrez Gene Summary for CD3G Gene

  • The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD3G Gene

CD3G (CD3g Molecule, Gamma (CD3-TCR Complex)) is a Protein Coding gene. Diseases associated with CD3G include immunodeficiency 17, cd3 gamma deficient and immunodeficiency due to defect in cd3-gamma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Akt Signaling. GO annotations related to this gene include protein heterodimerization activity and receptor signaling complex scaffold activity. An important paralog of this gene is CD3D.

UniProtKB/Swiss-Prot for CD3G Gene

  • The CD3 complex mediates signal transduction

Gene Wiki entry for CD3G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD3G Gene

Genomics for CD3G Gene

Regulatory Elements for CD3G Gene

Genomic Location for CD3G Gene

Start:
118,344,317 bp from pter
End:
118,355,161 bp from pter
Size:
10,845 bases
Orientation:
Plus strand

Genomic View for CD3G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD3G Gene

Proteins for CD3G Gene

  • Protein details for CD3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09693-CD3G_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD3 gamma chain
    Protein Accession:
    P09693
    Secondary Accessions:
    • Q2HIZ6

    Protein attributes for CD3G Gene

    Size:
    182 amino acids
    Molecular mass:
    20469 Da
    Quaternary structure:
    • The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

    Three dimensional structures from OCA and Proteopedia for CD3G Gene

neXtProt entry for CD3G Gene

Proteomics data for CD3G Gene at MOPED

Post-translational modifications for CD3G Gene

  • Ubiquitination at Lys32, Lys79, Lys93, Lys95, Lys150, and Lys164
  • Glycosylation at Asn52 and Asn92
  • Modification sites at PhosphoSitePlus

Other Protein References for CD3G Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CD3G Gene

Domains for CD3G Gene

Gene Families for CD3G Gene

HGNC:
  • CD :CD molecules

Graphical View of Domain Structure for InterPro Entry

P09693

UniProtKB/Swiss-Prot:

CD3G_HUMAN :
  • P09693
Domain:
  • A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 ITAM domain.
genes like me logo Genes that share domains with CD3G: view

Function for CD3G Gene

Molecular function for CD3G Gene

GENATLAS Biochemistry:
cell differentiation antigen CD3G (gp26),,gamma polypeptide (see CD3@),including an alternative splicing product pTAC12,component of the pre-T cell antigen receptor complex
UniProtKB/Swiss-Prot Function:
The CD3 complex mediates signal transduction

Gene Ontology (GO) - Molecular Function for CD3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IMP 12794121
GO:0005515 protein binding --
GO:0030159 receptor signaling complex scaffold activity NAS 12794121
GO:0042608 T cell receptor binding NAS 11186279
GO:0046982 protein heterodimerization activity IPI 9485181
genes like me logo Genes that share ontologies with CD3G: view
genes like me logo Genes that share phenotypes with CD3G: view

Animal Models for CD3G Gene

MGI Knock Outs for CD3G:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD3G Gene

Localization for CD3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD3G Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD3G Gene COMPARTMENTS Subcellular localization image for CD3G gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 9485181
GO:0016020 membrane --
GO:0042101 T cell receptor complex NAS 9485181
GO:0042105 alpha-beta T cell receptor complex IEA --
genes like me logo Genes that share ontologies with CD3G: view

Pathways for CD3G Gene

genes like me logo Genes that share pathways with CD3G: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CD3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 12794121
GO:0007163 establishment or maintenance of cell polarity IMP 12407027
GO:0007166 cell surface receptor signaling pathway IMP 12407027
GO:0015031 protein transport IMP 12794121
GO:0031295 T cell costimulation TAS --
genes like me logo Genes that share ontologies with CD3G: view

Compounds for CD3G Gene

(1) Drugbank Compounds for CD3G Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Muromonab
  • AntiCD3
140608-64-6 target

(1) Novoseek inferred chemical compound relationships for CD3G Gene

Compound -log(P) Hits PubMed IDs
tyrosine 31 4
genes like me logo Genes that share compounds with CD3G: view

Transcripts for CD3G Gene

Unigene Clusters for CD3G Gene

CD3g molecule, gamma (CD3-TCR complex):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD3G

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD3G Gene

No ASD Table

Relevant External Links for CD3G Gene

GeneLoc Exon Structure for
CD3G
ECgene alternative splicing isoforms for
CD3G

Expression for CD3G Gene

mRNA expression in normal human tissues for CD3G Gene

mRNA differential expression in normal tissues according to GTEx for CD3G Gene

This gene is overexpressed in Whole Blood (22.0), Spleen (7.1), and Small Intestine - Terminal Ileum (5.8).

Protein differential expression in normal tissues for CD3G Gene

This gene is overexpressed in CD4 Tcells (26.1), CD8 Tcells (21.0), Peripheral blood mononuclear cells (9.8), and Lymph node (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD3G Gene

SOURCE GeneReport for Unigene cluster for CD3G Gene Hs.2259

genes like me logo Genes that share expressions with CD3G: view

Expression partners for CD3G Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CD3G Gene

Orthologs for CD3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD3G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD3G 35
  • 80.15 (n)
  • 69.94 (a)
CD3G 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD3G 35
  • 80.77 (n)
  • 69.23 (a)
CD3G 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd3g 35
  • 79.56 (n)
  • 70.17 (a)
Cd3g 16
Cd3g 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD3G 35
  • 99.45 (n)
  • 100 (a)
CD3G 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd3g 35
  • 79.19 (n)
  • 71.27 (a)
oppossum
(Monodelphis domestica)
Mammalia CD3G 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD3G 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD3D 36
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
OneToMany
Species with no ortholog for CD3G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD3G Gene

ENSEMBL:
Gene Tree for CD3G (if available)
TreeFam:
Gene Tree for CD3G (if available)

Paralogs for CD3G Gene

Paralogs for CD3G Gene

Selected SIMAP similar genes for CD3G Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD3G: view

Variants for CD3G Gene

Sequence variations from dbSNP and Humsavar for CD3G Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs480720 -- 118,348,432(-) ccctc(A/C)tagac intron-variant
rs493302 -- 118,352,176(-) tgcag(G/T)ggcac intron-variant
rs579037 -- 118,351,747(-) TTCCA(A/G)ATAAC intron-variant
rs693187 -- 118,350,067(+) TCCTC(A/C)ACAGT intron-variant
rs1174718 -- 118,351,065(-) gacta(C/T)aggca intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CD3G Gene

Variant ID Type Subtype PubMed ID
nsv820176 CNV Loss 19587683

Relevant External Links for CD3G Gene

HapMap Linkage Disequilibrium report
CD3G
Human Gene Mutation Database (HGMD)
CD3G
Locus Specific Mutation Databases (LSDB)
CD3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD3G Gene

Disorders for CD3G Gene

(1) OMIM Diseases for CD3G Gene (186740)

UniProtKB/Swiss-Prot

CD3G_HUMAN
  • Immunodeficiency 17 (IMD17) [MIM:615607]: An autosomal recessive primary immunodeficiency characterized by highly variable clinical severity. Some patients have onset of severe recurrent infections in early infancy that may be lethal, whereas others may be only mildly affected or essentially asymptomatic into young adulthood. More severely affected patients may have evidence of autoimmune disease or enteropathy. The immunologic pattern is similar among patients, showing partial T-cell lymphopenia, decreased amounts of the CD3 complex, and impaired proliferative responses to T-cell receptor dependent stimuli. The phenotype in some patients is reminiscent of severe combined immunodeficiency. {ECO:0000269 PubMed:1635567, ECO:0000269 PubMed:17277165}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for CD3G Gene

(1) Novoseek inferred disease relationships for CD3G Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 2.94 3

Genatlas disease for CD3G Gene

immunodeficiency,severe,combined,defect in surface expression of T-cell receptor-CD3 complex and defective signal transduction,through the TCR

Relevant External Links for CD3G

Genetic Association Database (GAD)
CD3G
Human Genome Epidemiology (HuGE) Navigator
CD3G
genes like me logo Genes that share disorders with CD3G: view

Publications for CD3G Gene

  1. The implications of subunit interactions for the structure of the T cell receptor-CD3 complex. (PMID: 2138083) Koning F. … Coligan J.E. (Eur. J. Immunol. 1990) 3 23
  2. The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes. (PMID: 1826255) AlarcA^n B. … Terhorst C. (EMBO J. 1991) 3 23
  3. Identification of three NFAT binding motifs in the 5'-upstream region of the human CD3gamma gene that differentially bind NFATc1, NFATc2, and NF-kappa B p50. (PMID: 12374807) Badran B.M. … Willard-Gallo K.E. (J. Biol. Chem. 2002) 3 23
  4. Contribution of CD3 gamma to TCR regulation and signaling in human mature T lymphocytes. (PMID: 12407027) Torres P.S. … Regueiro J.R. (Int. Immunol. 2002) 3 23
  5. Down-modulation of TCR/CD3 surface complexes after HIV-1 infection is associated with differential expression of the viral regulatory genes. (PMID: 11298321) Willard-Gallo K.E. … Wolinsky S.M. (Eur. J. Immunol. 2001) 3 23

Products for CD3G Gene

Sources for CD3G Gene

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