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Aliases for CD3EAP Gene

Aliases for CD3EAP Gene

  • CD3e Molecule, Epsilon Associated Protein 2 3
  • PAF49 3 4 6
  • ASE1 3 4 6
  • CD3e Antigen, Epsilon Polypeptide Associated Protein 2 3
  • RNA Polymerase I-Associated Factor PAF49 3 4
  • Antisense To ERCC-1 Protein 3 4
  • ASE-1 3 4
  • CAST 3 4
  • DNA-Directed RNA Polymerase I Subunit RPA34 3
  • CD3 Epsilon Associated Protein 2
  • CD3-Epsilon-Associated Protein 4
  • CD3E-Associated Protein 4
  • Antisense To ERCC 1 2
  • A34.5 4

External Ids for CD3EAP Gene

Previous GeneCards Identifiers for CD3EAP Gene

  • GC19P050602
  • GC19P045909
  • GC19P042339

Summaries for CD3EAP Gene

GeneCards Summary for CD3EAP Gene

CD3EAP (CD3e Molecule, Epsilon Associated Protein) is a Protein Coding gene. Diseases associated with CD3EAP include multiple myeloma and lung cancer. Among its related pathways are Neuroscience and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for CD3EAP Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation

  • Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex

Gene Wiki entry for CD3EAP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD3EAP Gene

Genomics for CD3EAP Gene

Regulatory Elements for CD3EAP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD3EAP Gene

Start:
45,406,209 bp from pter
End:
45,410,766 bp from pter
Size:
4,558 bases
Orientation:
Plus strand

Genomic View for CD3EAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD3EAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD3EAP Gene

Proteins for CD3EAP Gene

  • Protein details for CD3EAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15446-RPA34_HUMAN
    Recommended name:
    DNA-directed RNA polymerase I subunit RPA34
    Protein Accession:
    O15446
    Secondary Accessions:
    • Q32N11
    • Q7Z5U2
    • Q9UPF6

    Protein attributes for CD3EAP Gene

    Size:
    510 amino acids
    Molecular mass:
    54986 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits. Interacts with TAF1A thereby associates with the SL1 complex. Interacts with UBTF. Interacts with POLR1E/PRAF1 through its N-terminal region (By similarity). Isoform 2 interacts with CD3E.
    Miscellaneous:
    • It is in an antisense orientation to and overlaps the gene of the DNA repair enzyme ERCC1. This gene overlap is conserved in mouse, suggesting an important biological function

    Alternative splice isoforms for CD3EAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD3EAP Gene

Proteomics data for CD3EAP Gene at MOPED

Post-translational modifications for CD3EAP Gene

  • Isoform 1 is phosphorylated on tyrosine residues in initiation-competent Pol I-beta complexes but not in Pol I-alpha complexes
  • Isoform 2 undergoes tyrosine phosphorylation upon T-cell receptor (TCR) stimulation. This phosphorylation has not been confirmed by other groups
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CD3EAP Gene

No data available for DME Specific Peptides for CD3EAP Gene

Domains for CD3EAP Gene

Protein Domains for CD3EAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD3EAP Gene

Graphical View of Domain Structure for InterPro Entry

O15446

UniProtKB/Swiss-Prot:

RPA34_HUMAN :
  • O15446
Family:
  • Belongs to the eukaryotic RPA34 RNA polymerase subunit family.
genes like me logo Genes that share domains with CD3EAP: view

No data available for Gene Families for CD3EAP Gene

Function for CD3EAP Gene

Molecular function for CD3EAP Gene

UniProtKB/Swiss-Prot Function:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation
UniProtKB/Swiss-Prot Function:
Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex

Gene Ontology (GO) - Molecular Function for CD3EAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003899 DNA-directed RNA polymerase activity IEA --
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CD3EAP: view

Phenotypes for CD3EAP Gene

GenomeRNAi human phenotypes for CD3EAP:
genes like me logo Genes that share phenotypes with CD3EAP: view

Animal Model Products

miRNA for CD3EAP Gene

miRTarBase miRNAs that target CD3EAP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD3EAP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CD3EAP Gene

Localization for CD3EAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD3EAP Gene

Nucleus, nucleolus. Chromosome. Note=Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD3EAP Gene COMPARTMENTS Subcellular localization image for CD3EAP gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for CD3EAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000120 RNA polymerase I transcription factor complex TAS 9426281
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CD3EAP: view

Pathways for CD3EAP Gene

genes like me logo Genes that share pathways with CD3EAP: view

Pathways by source for CD3EAP Gene

1 Qiagen pathway for CD3EAP Gene
1 Cell Signaling Technology pathway for CD3EAP Gene
1 BioSystems pathway for CD3EAP Gene

Gene Ontology (GO) - Biological Process for CD3EAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
GO:0006363 termination of RNA polymerase I transcription TAS --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 10373416
genes like me logo Genes that share ontologies with CD3EAP: view

Compounds for CD3EAP Gene

(1) PharmGKB related drug/compound annotations for CD3EAP Gene

Drug/compound Annotation
Platinum compounds CA
genes like me logo Genes that share compounds with CD3EAP: view

Transcripts for CD3EAP Gene

Unigene Clusters for CD3EAP Gene

CD3e molecule, epsilon associated protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD3EAP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD3EAP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for CD3EAP Gene

GeneLoc Exon Structure for
CD3EAP
ECgene alternative splicing isoforms for
CD3EAP

Expression for CD3EAP Gene

mRNA expression in normal human tissues for CD3EAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CD3EAP Gene

This gene is overexpressed in Liver (35.8) and Lung (14.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CD3EAP Gene

SOURCE GeneReport for Unigene cluster for CD3EAP Gene Hs.710495

genes like me logo Genes that share expressions with CD3EAP: view

Expression partners for CD3EAP Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CD3EAP Gene

Orthologs for CD3EAP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD3EAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD3EAP 35
  • 79.44 (n)
  • 70.16 (a)
CD3EAP 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD3EAP 35
  • 75.68 (n)
  • 63.54 (a)
CD3EAP 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd3eap 35
  • 71.17 (n)
  • 61.96 (a)
Cd3eap 16
Cd3eap 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD3EAP 35
  • 99.22 (n)
  • 99.22 (a)
CD3EAP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd3eap 35
  • 70.59 (n)
  • 58.6 (a)
oppossum
(Monodelphis domestica)
Mammalia CD3EAP 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD3EAP 36
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cd3eap 36
  • 27 (a)
OneToOne
Species with no ortholog for CD3EAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD3EAP Gene

ENSEMBL:
Gene Tree for CD3EAP (if available)
TreeFam:
Gene Tree for CD3EAP (if available)

Paralogs for CD3EAP Gene

No data available for Paralogs for CD3EAP Gene

Variants for CD3EAP Gene

Sequence variations from dbSNP and Humsavar for CD3EAP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_051875 -
VAR_051876 -
VAR_051877 -
VAR_051878 -
VAR_051879 -, -

Structural Variations from Database of Genomic Variants (DGV) for CD3EAP Gene

Variant ID Type Subtype PubMed ID
nsv833845 CNV Loss 17160897
nsv458711 CNV Gain 19166990
nsv428365 CNV Gain+Loss 18775914
nsv833846 CNV Loss 17160897

Relevant External Links for CD3EAP Gene

HapMap Linkage Disequilibrium report
CD3EAP
Human Gene Mutation Database (HGMD)
CD3EAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD3EAP Gene

Disorders for CD3EAP Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CD3EAP Gene in MalaCards »

(2) Diseases for CD3EAP Gene including...

Relevant External Links for CD3EAP

Genetic Association Database (GAD)
CD3EAP
Human Genome Epidemiology (HuGE) Navigator
CD3EAP
genes like me logo Genes that share disorders with CD3EAP: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CD3EAP Gene

Publications for CD3EAP Gene

  1. ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes. (PMID: 9426281) Whitehead C.M. … Rattner J.B. (Chromosoma 1997) 2 3 4
  2. CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells. (PMID: 10373416) Yamazaki T. … Saito T. (J. Biol. Chem. 1999) 2 3 4
  3. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. (PMID: 15226435) Yamamoto K. … Muramatsu M. (Mol. Cell. Biol. 2004) 2 3 23
  4. RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. (PMID: 16809778) Panov K.I. … Zomerdijk J.C.B.M. (Mol. Cell. Biol. 2006) 3 4
  5. Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study. (PMID: 16817948) Skjelbred C.F. … Kure E.H. (BMC Cancer 2006) 3 48

Products for CD3EAP Gene

Sources for CD3EAP Gene

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