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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD3EAP Gene

protein-coding   GIFtS: 53
GCID: GC19P045909

CD3e Molecule, Epsilon Associated Protein

(Previous names: CD3e antigen, epsilon polypeptide associated protein)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD3e Molecule, Epsilon Associated Protein1 2     A34.52 3
ASE12 3 5     ASE-12 3
PAF492 3 5     CAST2 3
CD3e Antigen, Epsilon Polypeptide Associated Protein1 2     CD3-Epsilon-Associated Protein2 3
Antisense To ERCC 11 2     CD3E-Associated Protein2 3
CD3 Epsilon Associated Protein1 2     RNA Polymerase I-Associated Factor PAF492 3
Antisense To ERCC-1 Protein2 3     DNA-Directed RNA Polymerase I Subunit RPA342

External Ids:    HGNC: 242191   Entrez Gene: 108492   Ensembl: ENSG000001178777   OMIM: 1073255   UniProtKB: O154463   

Export aliases for CD3EAP gene to outside databases

Previous GC identifers: GC19P050602 GC19P042339


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CD3EAP Gene: 
CD3EAP (CD3e molecule, epsilon associated protein) is a protein-coding gene. Diseases associated with CD3EAP include multiple myeloma, and basal cell carcinoma. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot: RPA34_HUMAN, O15446
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1
is involved in UBTF-activated transcription, presumably at a step following PIC formation
Function: Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex

Gene Wiki entry for CD3EAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD3EAP gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   p53   Bach2   E2F-2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD3EAP promoter sequence
   Search SABiosciences Chromatin IP Primers for CD3EAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD3EAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.3

CD3EAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD3EAP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045909:  view genomic region     (about GC identifiers)

Start:
45,909,467 bp from pter      End:
45,914,024 bp from pter
Size:
4,558 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RPA34_HUMAN, O15446 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase I subunit RPA34  
Size: 510 amino acids; 54986 Da
Subunit: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits. Interacts with
TAF1A thereby associates with the SL1 complex. Interacts with UBTF. Interacts with POLR1E/PRAF1 through its
N-terminal region (By similarity). Isoform 2 interacts with CD3E
Subcellular location: Nucleus, nucleolus. Chromosome. Note=Found at the fibrillar centers of the nucleolus in
interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes
Miscellaneous: It is in an antisense orientation to and overlaps the gene of the DNA repair enzyme ERCC1. This
gene overlap is conserved in mouse, suggesting an important biological function
Caution: It is not known whether the so-called human ASE1 and human CAST proteins represent two sides of a single
gene product with sharply different functional characteristics. Experiments done with the mouse homolog protein
are in favor of an implication of this gene in rRNA transcription instead of T-cell receptor signaling
Secondary accessions: Q32N11 Q7Z5U2 Q9UPF6
Alternative splicing: 2 isoforms:  O15446-1   O15446-2   (No experimental confirmation available. Has sharply different functional characteristics)

Explore the universe of human proteins at neXtProt for CD3EAP: NX_O15446

Explore proteomics data for CD3EAP at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform 2 undergoes tyrosine phosphorylation upon T-cell receptor (TCR) stimulation. This phosphorylation has not
    been confirmed by other groups
  • UniProtKB: Isoform 1 is phosphorylated on tyrosine residues in initiation-competent Pol I-beta complexes but not in Pol
    I-alpha complexes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15446

  • CD3EAP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD3EAP Protein Expression
    REFSEQ proteins: NP_036231.1  
    ENSEMBL proteins: 
     ENSP00000310966   ENSP00000467771   ENSP00000465099   ENSP00000466503  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000120RNA polymerase I transcription factor complex TAS9426281
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730nucleolus IDA--
    GO:0005736DNA-directed RNA polymerase I complex IEA--

    CD3EAP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013240 DNA-dir_RNA_pol1_su_RPA34

    Graphical View of Domain Structure for InterPro Entry O15446

    ProtoNet protein and cluster: O15446

    UniProtKB/Swiss-Prot: RPA34_HUMAN, O15446
    Similarity: Belongs to the eukaryotic RPA34 RNA polymerase subunit family


    CD3EAP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPA34_HUMAN, O15446
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1
    is involved in UBTF-activated transcription, presumably at a step following PIC formation
    Function: Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003899DNA-directed RNA polymerase activity IEA--
    GO:0005515protein binding ----
         
    CD3EAP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD3EAP:
     Synthetic lethal with Ras 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD3EAP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for CD3EAP
        TNF-alpha/NF-kB Signaling Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD3EAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/25 Interacting proteins for CD3EAP (O154462, 3 ENSP000003109664) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSRP1Q089452, 3, ENSP000002784124MINT-7264825 MINT-7264906 MINT-7264943 I2D: score=1 STRING: ENSP00000278412
    POLR1EQ9GZS12, 3, ENSP000003670294MINT-7264825 I2D: score=2 STRING: ENSP00000367029
    POLR1DQ9Y2S02, 3, ENSP000003024784MINT-7264825 I2D: score=1 STRING: ENSP00000302478
    NFKBIBQ156532, 3MINT-47849 I2D: score=3 
    SUPT16HQ9Y5B92, 3, ENSP000002162974MINT-7264825 MINT-7264906 MINT-7264892 I2D: score=1 STRING: ENSP00000216297
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS10373416
    GO:0009303rRNA transcription IEA--

    CD3EAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD3EAP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD3EAP (RPA34)

    1 PharmGKB related drug/compound annotation for CD3EAP gene    About this table
    Drug/compound PharmGKB Annotation
    Platinum compoundsCA  

    Search CenterWatch for drugs/clinical trials and news about CD3EAP / RPA34

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD3EAP gene: 
    NM_012099.1  

    Unigene Cluster for CD3EAP:

    CD3e molecule, epsilon associated protein
    Hs.710495  [show with all ESTs]
    Unigene Representative Sequence: NM_012099
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309424(uc002pbq.1 uc002pbr.1) ENST00000592852 ENST00000589804
    ENST00000590794
    miRNA
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    hsa-miR-370 hsa-miR-138 hsa-miR-548b-3p
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF017633.1 AK292183.1 BC009705.1 BC028109.1 BC038992.1 BC046141.1 BC054044.1 BC065251.1 
    BC108889.2 U86751.1 

    6 DOTS entries:

    DT.101981645  DT.453132  DT.99949247  DT.91686145  DT.91686496  DT.121483504 

    24/64 AceView cDNA sequences (see all 64):

    BU166593 BC065251 BX117092 BE796555 BC054044 CD624201 BQ212106 BC009705 
    NM_012099 AA155591 AF017633 CA442565 U86751 CD624203 CA424029 AA155606 
    BC028109 AI952716 BQ423643 BE782403 BM460317 BG387407 BE545243 BM798216 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CD3EAP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for CD3EAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD3EAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCCTCAAC
    CD3EAP Expression
    About this image


    See CD3EAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD3EAP

    SOURCE GeneReport for Unigene cluster: Hs.710495
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD3EAP gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd3eap1 , 5 CD3E antigen, epsilon polypeptide associated protein1, 5 70.31(n)1
    59.29(a)1
      7 (9.62 cM)5
    703331  NM_145822.21  NP_665821.11 
     193568495 
    zebrafish
    (Danio rerio)
    Actinopterygii BX950186.26
    Uncharacterized protein
    22(a)
    1 ↔ 1
    15(28136057-28150971)


    ENSEMBL Gene Tree for CD3EAP (if available)
    TreeFam Gene Tree for CD3EAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    6 SNPs in CD3EAP are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0518804
    ----see VAR_0518802 Q K mis40--------
    VAR_0518794
    ----see VAR_0518792 K Q mis40--------
    VAR_0518764
    ----see VAR_0518762 T A mis40--------
    VAR_0518774
    ----see VAR_0518772 K E mis40--------
    VAR_0518754
    ----see VAR_0518752 K T mis40--------
    VAR_0518784
    ----see VAR_0518782 D N mis40--------

    HapMap Linkage Disequilibrium report for CD3EAP (45909467 - 45914024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CD3EAP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833845CNV Loss17160897
    nsv833846CNV Loss17160897
    nsv458711CNV Gain19166990
    nsv428365CNV Gain+Loss18775914


    Human Gene Mutation Database (HGMD): CD3EAP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD3EAP
    DNA2.0 Custom Variant and Variant Library Synthesis for CD3EAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107325    OMIM disorders: --

    7 diseases for CD3EAP:    About MalaCards
    multiple myeloma    basal cell carcinoma    myeloma    lung cancer
    alcoholism    adenoma    colorectal cancer


    CD3EAP for disorders           About GeneDecksing

    Genetic Association Database (GAD): CD3EAP
    Human Genome Epidemiology (HuGE) Navigator: CD3EAP (10 documents)

    Export disorders for CD3EAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD3EAP gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with CD3EAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells. (PubMed id 10373416)1, 2, 3 Yamazaki T....Saito T. (1999)
    2. ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes. (PubMed id 9426281)1, 2, 3 Whitehead C.M.... Rattner J.B. (1997)
    3. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. (PubMed id 15226435)1, 3, 9 Yamamoto K....Muramatsu M. (2004)
    4. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    5. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    6. A polymorphism in NFKB1 is associated with improved e ffect of interferon-{alpha} maintenance treatment of patients with multiple mye loma after high-dose treatment with stem cell support. (PubMed id 19734419)1, 4 Vangsted A.J....Vogel U. (2009)
    7. Haplotype frequencies in a sub-region of chromosome 19q13.3, related to risk and prognosis of cancer, differ dramatically between ethnic groups. (PubMed id 19257887)1, 4 Schierup M.H.... B.A. (2009)
    8. A haplotype of polymorphisms in ASE-1, RAI and ERCC1 and the effects of tobacco smoking and alcohol consumption on risk of colorectal cancer: a Danish prospective case-cohort study. (PubMed id 18289367)1, 4 Hansen R.D....Vogel U. (2008)
    9. Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study. (PubMed id 16690207)1, 4 Vogel U....Raaschou-Nielsen O. (2007)
    10. Polymorphisms in the genes ERCC2, XRCC3 and CD3EAP influence treatment outcome in multiple myeloma patients undergoing autologous bone marrow transplantation. (PubMed id 17131345)1, 4 Vangsted A....Vogel U. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10849 HGNC: 24219 AceView: ASE-1 Ensembl:ENSG00000117877 euGenes: HUgn10849
    ECgene: CD3EAP H-InvDB: CD3EAP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD3EAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD3EAP gene:
    Search GeneIP for patents involving CD3EAP

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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