Aliases for CD3E Gene
External Ids for CD3E Gene
Previous GeneCards Identifiers for CD3E Gene
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD3E Gene
CD3E (CD3e Molecule, Epsilon (CD3-TCR Complex)) is a Protein Coding gene. Diseases associated with CD3E include t-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta and severe combined immune deficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive, cd3e-related. Among its related pathways are Immune System and NF-KappaB Family Pathway. GO annotations related to this gene include protein heterodimerization activity and signal transducer activity.
UniProtKB/Swiss-Prot for CD3E Gene
The CD3 complex mediates signal transduction