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Aliases for CD3E Gene

Aliases for CD3E Gene

  • CD3e Molecule 2 3 5
  • CD3e Antigen, Epsilon Polypeptide (TiT3 Complex) 2 3
  • T-Cell Surface Antigen T3/Leu-4 Epsilon Chain 3 4
  • CD3e Molecule, Epsilon (CD3-TCR Complex) 2 3
  • T3E 3 4
  • T-Cell Antigen Receptor Complex, Epsilon Subunit Of T3 3
  • T-Cell Surface Glycoprotein CD3 Epsilon Chain 3
  • CD3e Antigen 4
  • CD3-Epsilon 3
  • IMD18 3
  • TCRE 3

External Ids for CD3E Gene

Previous GeneCards Identifiers for CD3E Gene

  • GC11P120532
  • GC11P119687
  • GC11P118209
  • GC11P117713
  • GC11P117680
  • GC11P114108

Summaries for CD3E Gene

Entrez Gene Summary for CD3E Gene

  • The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD3E Gene

CD3E (CD3e Molecule) is a Protein Coding gene. Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are CXCR4-mediated signaling events and HTLV-I infection. GO annotations related to this gene include protein heterodimerization activity and signal transducer activity.

UniProtKB/Swiss-Prot for CD3E Gene

  • The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).

Gene Wiki entry for CD3E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD3E Gene

Genomics for CD3E Gene

Regulatory Elements for CD3E Gene

Enhancers for CD3E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F118273 1.6 FANTOM5 Ensembl ENCODE 17 -28.8 -28817 5.3 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 BRCA1 ZNF48 SLC30A9 GLIS2 CD3E MPZL3 SCN4B CD3D CD3G UBE4A ENSG00000271751 JAML MPZL2 FXYD6
GH11F118237 1.7 FANTOM5 Ensembl ENCODE 12.9 -64.2 -64184 5.5 PKNOX1 ARNT SIN3A YY1 ZNF207 FOS SP5 ZHX2 JUNB REST JAML MPZL3 ENSG00000254909 ENSG00000254428 RPL23AP64 UBE4A CCDC84 CD3E HINFP IL10RA
GH11F117948 1.5 FANTOM5 Ensembl ENCODE 12.3 -353.0 -352996 5.9 PKNOX1 TBL1XR1 ARID4B RAD21 GLIS2 GATA2 SCRT2 ZNF143 ZNF263 ZNF654 IL10RA TMPRSS13 CD3E CD3G DSCAML1 ENSG00000254844 FXYD6 FXYD6-FXYD2 ENSG00000254528 FXYD2
GH11F118309 1.7 FANTOM5 Ensembl ENCODE 10.8 +11.8 11764 13.4 HDGF PKNOX1 ATF1 DMAP1 FEZF1 ZNF48 ZNF121 SP5 REST PPARG CD3G CD3D MPZL3 UBE4A KMT2A CD3E ENSG00000255384 HMBS ARCN1 ENSG00000271751
GH11F118210 1.3 Ensembl ENCODE 11.1 -90.0 -89962 8.4 HDGF ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 FOS MPZL3 JAML CD3D CD3G CD3E MPZL2 GC11M118201 HSPE1P18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD3E on UCSC Golden Path with GeneCards custom track

Promoters for CD3E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001406865 755 1401 ELF3 SAP130 CEBPG RAD21 TEAD3 YY1 ZNF335 ZFHX2 ZNF366 PRDM10

Genomic Location for CD3E Gene

118,304,545 bp from pter
118,316,175 bp from pter
11,631 bases
Plus strand

Genomic View for CD3E Gene

Genes around CD3E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD3E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD3E Gene

Proteins for CD3E Gene

  • Protein details for CD3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell surface glycoprotein CD3 epsilon chain
    Protein Accession:
    Secondary Accessions:
    • A8K997

    Protein attributes for CD3E Gene

    207 amino acids
    Molecular mass:
    23147 Da
    Quaternary structure:
    • The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. Interacts with CD6 (PubMed:15294938).

    Three dimensional structures from OCA and Proteopedia for CD3E Gene

neXtProt entry for CD3E Gene

Post-translational modifications for CD3E Gene

  • Ubiquitination at Lys 104 and Lys 177
  • Modification sites at PhosphoSitePlus

Other Protein References for CD3E Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD3E (CD3E)

No data available for DME Specific Peptides for CD3E Gene

Domains & Families for CD3E Gene

Gene Families for CD3E Gene

Suggested Antigen Peptide Sequences for CD3E Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 ITAM domain.
genes like me logo Genes that share domains with CD3E: view

Function for CD3E Gene

Molecular function for CD3E Gene

GENATLAS Biochemistry:
cell differentiation antigen CD3E (gp16),16kDa,epsilon polypeptide,TiT3 complex (see CD3@)
UniProtKB/Swiss-Prot Function:
The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).

Gene Ontology (GO) - Molecular Function for CD3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA,NAS 9485181
GO:0005057 signal transducer activity, downstream of receptor TAS 1370449
GO:0005515 protein binding IPI 7761456
GO:0017124 SH3 domain binding IPI 12110186
genes like me logo Genes that share ontologies with CD3E: view
genes like me logo Genes that share phenotypes with CD3E: view

Human Phenotype Ontology for CD3E Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD3E Gene

MGI Knock Outs for CD3E:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD3E Gene

Localization for CD3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD3E Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD3E gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane NAS 9485181
GO:0005911 cell-cell junction IEA --
GO:0009897 external side of plasma membrane IEA,IDA 11390434
genes like me logo Genes that share ontologies with CD3E: view

Pathways & Interactions for CD3E Gene

genes like me logo Genes that share pathways with CD3E: view

Gene Ontology (GO) - Biological Process for CD3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002669 positive regulation of T cell anergy IEA --
GO:0006461 protein complex assembly NAS 9886373
GO:0007166 cell surface receptor signaling pathway IEA,NAS 12110186
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 8530500
genes like me logo Genes that share ontologies with CD3E: view

No data available for SIGNOR curated interactions for CD3E Gene

Drugs & Compounds for CD3E Gene

(10) Drugs for CD3E Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Muromonab Approved, Investigational Pharma binder, Target 0
Catumaxomab Pharma Antibody Others 0
MT-103 Pharma 0
MT110 Pharma Others 0
genes like me logo Genes that share compounds with CD3E: view

Transcripts for CD3E Gene

Unigene Clusters for CD3E Gene

CD3e molecule, epsilon (CD3-TCR complex):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD3E Gene

No ASD Table

Relevant External Links for CD3E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD3E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD3E Gene

mRNA differential expression in normal tissues according to GTEx for CD3E Gene

This gene is overexpressed in Whole Blood (x28.8), Spleen (x6.2), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for CD3E Gene

This gene is overexpressed in Tlymphocyte (21.8), CD8 Tcells (16.0), and Peripheral blood mononuclear cells (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD3E Gene

Protein tissue co-expression partners for CD3E Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD3E Gene:


SOURCE GeneReport for Unigene cluster for CD3E Gene:

genes like me logo Genes that share expression patterns with CD3E: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CD3E Gene

Orthologs for CD3E Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD3E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD3E 34 35
  • 99.36 (n)
(Bos Taurus)
Mammalia CD3E 34 35
  • 78.3 (n)
(Canis familiaris)
Mammalia CD3E 34 35
  • 76.53 (n)
(Rattus norvegicus)
Mammalia Cd3e 34
  • 73.73 (n)
(Mus musculus)
Mammalia Cd3e 34 16 35
  • 72.66 (n)
(Monodelphis domestica)
Mammalia CD3E 35
  • 56 (a)
(Gallus gallus)
Aves CD3E 34 35
  • 57.58 (n)
(Anolis carolinensis)
Reptilia CD3E 35
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd3e 34
  • 52.25 (n)
Species where no ortholog for CD3E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD3E Gene

Gene Tree for CD3E (if available)
Gene Tree for CD3E (if available)

Paralogs for CD3E Gene

No data available for Paralogs for CD3E Gene

Variants for CD3E Gene

Sequence variations from dbSNP and Humsavar for CD3E Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs121918659 Pathogenic 118,312,690(+) ACTAT(A/G)GCAAC reference, stop-gained
rs483352928 Pathogenic 118,313,876(+) AGGGG(C/T)AAGGC splice-donor-variant
rs483352929 Pathogenic 118,312,642(+) TGGAA(-/CC)ACAGT reference, frameshift-variant
rs2231447 Likely benign 118,313,861(+) GCTGG(A/C/T)GGCAG reference, synonymous-codon
rs78373007 Likely benign 118,313,852(+) GGAGC(A/C/G)GGTGC reference, synonymous-codon

Variation tolerance for CD3E Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD3E Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD3E Gene

Disorders for CD3E Gene

MalaCards: The human disease database

(9) MalaCards diseases for CD3E Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CD3E in MalaCards View complete list of genes associated with diseases


  • Immunodeficiency 18 (IMD18) [MIM:615615]: An autosomal recessive primary immunodeficiency characterized by onset in infancy or early childhood of recurrent infections. The severity is variable, encompassing both a mild immunodeficiency and severe combined immunodeficiency (SCID), resulting in early death without bone marrow transplantation in some patients. Immunologic work-up of the IMD18 SCID patients shows a T cell-negative, B cell-positive, natural killer (NK) cell-positive phenotype, whereas T-cell development is not impaired in the mild form of IMD18. {ECO:0000269 PubMed:15546002, ECO:0000269 PubMed:8490660}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for CD3E Gene

immunodeficiency,severe,combined,defect in surface expression of T-cell receptor-CD3 complex and defective signal transduction,through the TCR

Relevant External Links for CD3E

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CD3E: view

Publications for CD3E Gene

  1. Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. (PMID: 20478055) Brophy K. … McManus R. (BMC Med. Genet. 2010) 3 46 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. (PMID: 18504423) Wong M.L. … Licinio J. (Mol. Psychiatry 2008) 3 46 64
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4 64

Products for CD3E Gene

Sources for CD3E Gene

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