Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD3E Gene

Aliases for CD3E Gene

  • CD3e Molecule 2 3
  • CD3e Molecule, Epsilon (CD3-TCR Complex) 2 3 5
  • CD3e Antigen, Epsilon Polypeptide (TiT3 Complex) 2 3
  • T-Cell Surface Antigen T3/Leu-4 Epsilon Chain 3 4
  • T3E 3 4
  • T-Cell Antigen Receptor Complex, Epsilon Subunit Of T3 3
  • CD3e Antigen 4
  • CD3-Epsilon 3
  • IMD18 3
  • TCRE 3

External Ids for CD3E Gene

Previous GeneCards Identifiers for CD3E Gene

  • GC11P120532
  • GC11P119687
  • GC11P118209
  • GC11P117713
  • GC11P117680
  • GC11P114108

Summaries for CD3E Gene

Entrez Gene Summary for CD3E Gene

  • The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD3E Gene

CD3E (CD3e Molecule) is a Protein Coding gene. Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are CTLA4 Signaling and HTLV-I infection. GO annotations related to this gene include protein heterodimerization activity and signal transducer activity.

UniProtKB/Swiss-Prot for CD3E Gene

  • The CD3 complex mediates signal transduction, resulting in T cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).

Gene Wiki entry for CD3E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD3E Gene

Genomics for CD3E Gene

Regulatory Elements for CD3E Gene

Enhancers for CD3E Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD3E on UCSC Golden Path with GeneCards custom track

Promoters for CD3E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD3E on UCSC Golden Path with GeneCards custom track

Genomic Location for CD3E Gene

118,304,545 bp from pter
118,316,175 bp from pter
11,631 bases
Plus strand

Genomic View for CD3E Gene

Genes around CD3E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD3E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD3E Gene

Proteins for CD3E Gene

  • Protein details for CD3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell surface glycoprotein CD3 epsilon chain
    Protein Accession:
    Secondary Accessions:
    • A8K997

    Protein attributes for CD3E Gene

    207 amino acids
    Molecular mass:
    23147 Da
    Quaternary structure:
    • The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. Interacts with CD6 (PubMed:15294938).

    Three dimensional structures from OCA and Proteopedia for CD3E Gene

neXtProt entry for CD3E Gene

Proteomics data for CD3E Gene at MOPED

Post-translational modifications for CD3E Gene

  • Ubiquitination at Lys 104 and Lys 177
  • Modification sites at PhosphoSitePlus

Other Protein References for CD3E Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD3E (CD3E)

No data available for DME Specific Peptides for CD3E Gene

Domains & Families for CD3E Gene

Gene Families for CD3E Gene

Suggested Antigen Peptide Sequences for CD3E Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 ITAM domain.
genes like me logo Genes that share domains with CD3E: view

Function for CD3E Gene

Molecular function for CD3E Gene

GENATLAS Biochemistry:
cell differentiation antigen CD3E (gp16),16kDa,epsilon polypeptide,TiT3 complex (see CD3@)
UniProtKB/Swiss-Prot Function:
The CD3 complex mediates signal transduction, resulting in T cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).
genes like me logo Genes that share phenotypes with CD3E: view

Human Phenotype Ontology for CD3E Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD3E Gene

MGI Knock Outs for CD3E:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for CD3E Gene

Localization for CD3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD3E Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD3E Gene COMPARTMENTS Subcellular localization image for CD3E gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD3E: view

Pathways & Interactions for CD3E Gene

genes like me logo Genes that share pathways with CD3E: view

Gene Ontology (GO) - Biological Process for CD3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002669 positive regulation of T cell anergy IEA --
GO:0007166 cell surface receptor signaling pathway IEA,NAS 12110186
GO:0007584 response to nutrient IEA --
GO:0010628 positive regulation of gene expression IMP 23817958
GO:0010629 negative regulation of gene expression IMP 23817958
genes like me logo Genes that share ontologies with CD3E: view

No data available for SIGNOR curated interactions for CD3E Gene

Drugs & Compounds for CD3E Gene

(10) Drugs for CD3E Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Muromonab Approved, Investigational Pharma binder, Target 0
Catumaxomab Pharma Antibody Others 0
MT-103 Pharma 0
MT110 Pharma Others 0
genes like me logo Genes that share compounds with CD3E: view

Transcripts for CD3E Gene

Unigene Clusters for CD3E Gene

CD3e molecule, epsilon (CD3-TCR complex):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD3E Gene

No ASD Table

Relevant External Links for CD3E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD3E Gene

mRNA expression in normal human tissues for CD3E Gene

mRNA differential expression in normal tissues according to GTEx for CD3E Gene

This gene is overexpressed in Whole Blood (x28.8), Spleen (x6.2), and Small Intestine - Terminal Ileum (x4.2).

Protein differential expression in normal tissues from HIPED for CD3E Gene

This gene is overexpressed in Tlymphocyte (21.8), CD8 Tcells (16.0), and Peripheral blood mononuclear cells (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD3E Gene

SOURCE GeneReport for Unigene cluster for CD3E Gene Hs.3003

genes like me logo Genes that share expression patterns with CD3E: view

Protein tissue co-expression partners for CD3E Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CD3E Gene

Orthologs for CD3E Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD3E Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD3E 35
  • 78.3 (n)
  • 67.19 (a)
CD3E 36
  • 66 (a)
(Canis familiaris)
Mammalia CD3E 35
  • 76.53 (n)
  • 63.78 (a)
CD3E 36
  • 61 (a)
(Mus musculus)
Mammalia Cd3e 35
  • 72.66 (n)
  • 65.08 (a)
Cd3e 16
Cd3e 36
  • 63 (a)
(Pan troglodytes)
Mammalia CD3E 35
  • 99.36 (n)
  • 99.03 (a)
CD3E 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cd3e 35
  • 73.73 (n)
  • 66.85 (a)
(Monodelphis domestica)
Mammalia CD3E 36
  • 56 (a)
(Gallus gallus)
Aves CD3E 35
  • 57.58 (n)
  • 47.88 (a)
CD3E 36
  • 43 (a)
(Anolis carolinensis)
Reptilia CD3E 36
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd3e 35
  • 52.25 (n)
  • 42.57 (a)
Species with no ortholog for CD3E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD3E Gene

Gene Tree for CD3E (if available)
Gene Tree for CD3E (if available)

Paralogs for CD3E Gene

No data available for Paralogs for CD3E Gene

Variants for CD3E Gene

Sequence variations from dbSNP and Humsavar for CD3E Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs531086 -- 118,304,168(-) ATGTA(A/C)CCTTT upstream-variant-2KB
rs554964 -- 118,315,057(+) TAACA(A/G)AGAGT intron-variant
rs1042847 -- 118,316,119(+) CCGTA(A/T)ATGTG utr-variant-3-prime
rs1126924 -- 118,307,292(+) GTTGG(C/T)GTTTG reference, synonymous-codon
rs1599809 -- 118,308,485(-) TCATT(A/C/T)CATAT intron-variant

Variation tolerance for CD3E Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD3E Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD3E Gene

Disorders for CD3E Gene

MalaCards: The human disease database

(9) MalaCards diseases for CD3E Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CD3E in MalaCards View complete list of genes associated with diseases


  • Immunodeficiency 18 (IMD18) [MIM:615615]: An autosomal recessive primary immunodeficiency characterized by onset in infancy or early childhood of recurrent infections. The severity is variable, encompassing both a mild immunodeficiency and severe combined immunodeficiency (SCID), resulting in early death without bone marrow transplantation in some patients. Immunologic work-up of the IMD18 SCID patients shows a T cell-negative, B cell-positive, natural killer (NK) cell-positive phenotype, whereas T-cell development is not impaired in the mild form of IMD18. {ECO:0000269 PubMed:15546002, ECO:0000269 PubMed:8490660}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for CD3E Gene

immunodeficiency,severe,combined,defect in surface expression of T-cell receptor-CD3 complex and defective signal transduction,through the TCR

Relevant External Links for CD3E

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CD3E: view

Publications for CD3E Gene

  1. Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. (PMID: 20478055) Brophy K. … McManus R. (BMC Med. Genet. 2010) 3 48 67
  2. Lentiviral Nef proteins manipulate T cells in a subset-specific manner. (PMID: 25505066) Yu H. … Kirchhoff F. (J. Virol. 2015) 3
  3. Identification of the Docking Site for CD3 on the T Cell Receptor I^ Chain by Solution NMR. (PMID: 26109064) He Y. … Orban J. (J. Biol. Chem. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo. (PMID: 24470497) Borroto A. … AlarcA^n B. (J. Immunol. 2014) 3

Products for CD3E Gene

Sources for CD3E Gene