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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD3E Gene

protein-coding   GIFtS: 63
GCID: GC11P118209

CD3e Molecule, Epsilon (CD3-TCR Complex)

(Previous names: CD3e antigen, epsilon polypeptide (TiT3 complex))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD3e Molecule, Epsilon (CD3-TCR Complex)1 2     TCRE2
CD3e Antigen, Epsilon Polypeptide (TiT3 Complex)1 2     T-Cell Antigen Receptor Complex, Epsilon Subunit Of T32
T3E2 3     T-Cell Surface Glycoprotein CD3 Epsilon Chain2
T-Cell Surface Antigen T3/Leu-4 Epsilon Chain2 3     CD3e Antigen3
CD3-epsilon2     

External Ids:    HGNC: 16741   Entrez Gene: 9162   Ensembl: ENSG000001988517   OMIM: 1868305   UniProtKB: P077663   

Export aliases for CD3E gene to outside databases

Previous GC identifers: GC11P120532 GC11P119687 GC11P117713 GC11P117680 GC11P114108


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD3E Gene:
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta,
and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This
complex plays an important role in coupling antigen recognition to several intracellular signal-transduction
pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on
chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause
immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CD3E Gene: 
CD3E (CD3e molecule, epsilon (CD3-TCR complex)) is a protein-coding gene. Diseases associated with CD3E include cd3epsilon deficiency, and hemometra, and among its related super-pathways are T cell receptor signaling pathway and Immune response IL-12-induced IFN-gamma production. GO annotations related to this gene include SH3 domain binding and protein heterodimerization activity.

UniProtKB/Swiss-Prot: CD3E_HUMAN, P07766
Function: The CD3 complex mediates signal transduction

Gene Wiki entry for CD3E (T-cell surface glycoprotein CD3 epsilon chain) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD3E gene promoter:
         GR   STAT5B   p53   GR-beta   SREBP-1c   Cdc5   SREBP-1b   SREBP-1a   GR-alpha   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD3E promoter sequence
   Search SABiosciences Chromatin IP Primers for CD3E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD3E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23

CD3E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD3E gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118209:  view genomic region     (about GC identifiers)

Start:
118,175,260 bp from pter      End:
118,186,890 bp from pter
Size:
11,631 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD3E_HUMAN, P07766 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD3 epsilon chain precursor  
Size: 207 amino acids; 23147 Da
Subunit: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer
coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta
Subcellular location: Membrane; Single-pass type I membrane protein
4 PDB 3D structures from and Proteopedia for CD3E:
1A81 (3D)        1SY6 (3D)        1XIW (3D)        2ROL (3D)    
Secondary accessions: A8K997

Explore the universe of human proteins at neXtProt for CD3E: NX_P07766

Explore proteomics data for CD3E at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07766

  • CD3E Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD3E Protein Expression
    REFSEQ proteins: NP_000724.1  
    ENSEMBL proteins: 
     ENSP00000354566   ENSP00000433975  
    Reactome Protein details: P07766
    Human Recombinant Protein Products for CD3E: 
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    OriGene Protein Over-expression Lysate for CD3E
    OriGene MassSpec for CD3E 
    OriGene Custom Protein Services for CD3E
    GenScript Custom Purified and Recombinant Proteins Services for CD3E
    Novus Biologicals CD3E Proteins
    Novus Biologicals CD3E Lysate
    Sino Biological Recombinant Protein for CD3E
    Sino Biological Cell Lysate for CD3E 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS9485181
    GO:0009897external side of plasma membrane IDA11390434
    GO:0016020membrane ----

    CD3E for ontologies           About GeneDecksing



    CD3E Antibody Products: 
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    Novus Biologicals CD3E Antibodies
    Abcam antibodies for CD3E
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CD3E
    LSBio Antibodies in human, mouse, rat for CD3E 

    Assay Products for CD3E: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD3E
    R&D Systems Proteome Profiler Antibody Arrays for CD3E (CD3 epsilon)
    GenScript Custom Assay Services for CD3E
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR003110 Phos_immunorcpt_sig_ITAM
     IPR015477 CD3_epsilon

    Graphical View of Domain Structure for InterPro Entry P07766

    ProtoNet protein and cluster: P07766

    2 Blocks protein domains:
    IPB003110 Phosphorylated immunoreceptor signaling ITAM
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: CD3E_HUMAN, P07766
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 1 ITAM domain


    CD3E for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD3E_HUMAN, P07766
    Function: The CD3 complex mediates signal transduction

         Genatlas biochemistry entry for CD3E:
    cell differentiation antigen CD3E (gp16),16kDa,epsilon polypeptide,TiT3 complex (see CD3@)

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity ----
    GO:0004888transmembrane signaling receptor activity NAS9485181
    GO:0005057receptor signaling protein activity TAS1370449
    GO:0005515protein binding IPI11855827
    GO:0017124SH3 domain binding IPI12110186
         
    CD3E for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD3E:
     Increases Tamoxifen sensitivit 

         7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cd3e):
     behavior/neurological  cellular  hematopoietic system  immune system  integument 
     mortality/aging  nervous system 

    CD3E for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD3E: Cd3etm1.1Lov Cd3etm1Mal Cd3etm1Lov Cd3etm1Cpt

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD3E 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD3E

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD3E 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD3E 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CD3E:
    hsa-miR-615-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD3E 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD3E
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CD3E

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: CD3E (NM_000733)
    Sino Biological Human cDNA Clone for CD3E
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD3E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD3E
    Sirion Biotech Customized lentivirus for stable overexpression of CD3E 
                         Customized lentivirus expression plasmids for stable overexpression of CD3E 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CD3E
    Search LifeMap BioReagents cell lines for CD3E
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD3E


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD3E About   (see all 48)                                                                                              See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway
    T cell receptor signaling pathway0.38
    TCR Signaling Pathway0.35
    2Immune response IL-12-induced IFN-gamma production
    Immune response IL-12-induced IFN-gamma production0.88
    IL12-mediated signaling events0.33
    3CD28 co-stimulation
    Costimulation by the CD28 family0.41
    CTLA4 Signaling0.31
    4Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.85
    PD-1 signaling0.77
    Phosphorylation of CD3 and TCR zeta chains0.85
    Generation of second messenger molecules0.64
    5ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    Calcium Mediated T-Cell Apoptosis0.31
    CD28 Signaling in T-Helper Cell0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/13 EMD Millipore Pathways for CD3E (see all 13)
        Immune response Antigen presentation by MHC class II
    Signal transduction IP3 signaling
    Immune response NFAT in immune response
    Immune response Antigen presentation by MHC class I
    Immune response CD28 signaling

    2 R&D Systems Pathways for CD3E
        Th1 Differentiation
    Th17 Differentiation

    5/25 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD3E (see all 25)
        Calcium Mediated T-Cell Apoptosis
    Nur77 Signaling in T-Cell
    Intracellular Calcium Signaling
    NFAT Signaling and Lymphocyte Interactions
    CTL Mediated Apoptosis

    1 Cell Signaling Technology (CST) Pathway for CD3E
        Lymphocyte Signaling

    5/13 GeneGo (Thomson Reuters) Pathways for CD3E (see all 13)
        G-protein signaling Regulation of RAC1 activity
    Immune response Antigen presentation by MHC class II
    Immune response CD28 signaling
    Immune response IL-12-induced IFN-gamma production
    G-protein signaling N-RAS regulation pathway

    5/8 BioSystems Pathways for CD3E (see all 8)
        TCR Signaling Pathway
    IL23-mediated signaling events
    Downstream signaling in naive CD8+ T cells
    TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells


    5/10        Reactome Pathways for CD3E (see all 10)
        Costimulation by the CD28 family
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Translocation of ZAP-70 to Immunological synapse
    Downstream TCR signaling


    5/6         Kegg Pathways  (Kegg details for CD3E) (see all 6):
        Hematopoietic cell lineage
    T cell receptor signaling pathway
    Chagas disease (American trypanosomiasis)
    Measles
    HTLV-I infection


    CD3E for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD3E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/101 Interacting proteins for CD3E (P077662, 3 ENSP000003545664) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163332, 3, ENSP000002889864MINT-7233971 MINT-7234008 MINT-7214135 MINT-7213923 MINT-7233987 MINT-7214094 I2D: score=5 STRING: ENSP00000288986
    SYKP434052, 3, ENSP000003648984MINT-8031530 MINT-8035866 MINT-8035897 MINT-8031546 MINT-8035882 MINT-8031561 I2D: score=4 STRING: ENSP00000364898
    ZAP70P434032, 3, ENSP000002649724MINT-8031576 MINT-8035855 MINT-8031519 I2D: score=4 STRING: ENSP00000264972
    LCKP062392, 3, ENSP000003378254MINT-8035912 I2D: score=3 STRING: ENSP00000337825
    EPS8Q129292, 3, ENSP000002811724MINT-7214058 I2D: score=1 STRING: ENSP00000281172
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002669positive regulation of T cell anergy IEA--
    GO:0006461protein complex assembly NAS9886373
    GO:0007166cell surface receptor signaling pathway NAS12110186
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS8530500
    GO:0007172signal complex assembly TAS8490660

    CD3E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD3E

    1 DrugBank Compound for CD3E    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MuromonabAntiCD3 (see all 2)140608-64-6targetbinder11752352 17016423 17139284

    Search CenterWatch for drugs/clinical trials and news about CD3E

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD3E gene: 
    NM_000733.3  

    Unigene Cluster for CD3E:

    CD3e molecule, epsilon (CD3-TCR complex)
    Hs.3003  [show with all ESTs]
    Unigene Representative Sequence: AK091285
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361763(uc001psq.4) ENST00000529713(uc010rya.2) ENST00000528435
    ENST00000526146 ENST00000528600 ENST00000531913
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CD3E:
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD3E
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    Additional mRNA sequence: 

    AK091285.1 AK292612.1 AK301255.1 BC049847.1 X03884.1 

    5 DOTS entries:

    DT.311930  DT.100848393  DT.100848394  DT.120742596  DT.99939445 

    24/83 AceView cDNA sequences (see all 83):

    BU730526 BQ052837 CR591071 CR608821 AA311109 BU783375 AW135942 AW135096 
    BC049847 AI935376 AL558308 AW204533 T28978 CR610563 CR609568 NM_000733 
    BI836902 BI834266 BM704364 BX437412 BX421803 BP339232 BI517629 AA306346 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD3E expression in normal human tissues (normalized intensities)      CD3E embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD3E Expression
    About this image


    CD3E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 10 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Peripheral blood-derived hematopoietic stem cells
             Peripheral blood Pan-T Cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
             Thymus   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Cord Blood CD133- Cells   
     
     Endothelium (Cardiovascular System)
             Peripheral blood-derived endothelial progenitor cells
     
     Bone (Muscoskeletal System)
             Bone marrow-derived mesenchymal stem cells

    See CD3E Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD3E

    SOURCE GeneReport for Unigene cluster: Hs.3003
        SABiosciences Expression via Pathway-Focused PCR Arrays including CD3E (see all 7): 
              Cell Surface Markers in human mouse rat
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Insulin Resistance in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD3E
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD3E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD3E gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd3e1 , 5 CD3 antigen, epsilon polypeptide1, 5 72.49(n)1
    64.02(a)1
      9 (24.84 cM)5
    125011  NM_007648.41  NP_031674.11 
     449987435 
    chicken
    (Gallus gallus)
    Aves CD3E1 CD3e molecule, epsilon (CD3-TCR complex) 57.78(n)
    49.7(a)
      396062  NM_206904.1  NP_996787.1 
    lizard
    (Anolis carolinensis)
    Reptilia CD3E6
    CD3e molecule, epsilon (CD3-TCR complex)
    36(a)
    1 ↔ 1
    GL343767.1(104246-112199)


    ENSEMBL Gene Tree for CD3E (if available)
    TreeFam Gene Tree for CD3E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/433 SNPs in CD3E are shown (see all 433)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783730071,2
    C,Fprobable-non-pathogenic1118048226(+) GGAGCG/AGGTGC 2 /A syn12Minor allele frequency- A:0.00WA NA 4550
    rs22314471,2
    C,Fprobable-non-pathogenic1118048235(+) GCTGGC/TGGCAG 2 G syn13Minor allele frequency- T:0.01EA NA EU 5577
    rs680867741,2
    C--114108580(+) TAGGT-/CAAAAA 1 -- us2k10--------
    rs1877964361,2
    --118037001(+) CTCATA/GTCTGT 1 -- us2k10--------
    rs1408705581,2
    --118037035(+) AGGTGA/GGCAGA 1 -- us2k10--------
    rs1912501201,2
    --118037124(+) TGGGCA/GTGGTG 1 -- us2k10--------
    rs1846699781,2
    --118037221(+) TCGCAC/TGATTG 1 -- us2k10--------
    rs2008068791,2
    C--118037261(+) TTCAT-/TAAAAA 1 -- us2k10--------
    rs1446849021,2
    --118037285(+) TTCCAC/TTTGAA 1 -- us2k10--------
    rs591389301,2
    C--118037441(+) TTTTTC/TATTTT 1 -- us2k15Minor allele frequency- T:0.38WA NA EA 362

    HapMap Linkage Disequilibrium report for CD3E (118175260 - 118186890 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CD3E: --

    Human Gene Mutation Database (HGMD): CD3E

    Locus Specific Mutation Databases (LSDB): CD3E
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD3E
    DNA2.0 Custom Variant and Variant Library Synthesis for CD3E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 186830   
    OMIM disorders: 608971  
    20 diseases for CD3E:    About MalaCards
    cd3epsilon deficiency    hemometra    severe combined immune deficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive, cd3e-related    small intestine lymphoma
    renal oncocytoma    myoma    severe combined immunodeficiency    amenorrhea
    trypanosomiasis    chagas disease    measles    aplastic anemia
    hiv type 1    multiple myeloma    basal cell carcinoma    myeloma
    insulin resistance    hepatitis b    anemia    hepatitis

    4 diseases from the University of Copenhagen DISEASES database for CD3E:
    Hemometra     Amenorrhea     Myoma     Small intestine lymphoma

    CD3E for disorders           About GeneDecksing

    Genatlas disease: CD3E
    immunodeficiency,severe,combined,defect in surface expression of T-cell receptor-CD3 complex and defective signal
    transduction,through the TCR

    Genetic Association Database (GAD): CD3E
    Human Genome Epidemiology (HuGE) Navigator: CD3E (7 documents)

    Export disorders for CD3E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD3E gene, integrated from 9 sources (see all 126):
    (articles sorted by number of sources associating them with CD3E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of 6 candidate genes on chromosome 11q23 f or coeliac disease susceptibility: a case control study. (PubMed id 20478055)1, 4 Brophy K....McManus R. (2010)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. (PubMed id 18504423)1, 4 Wong M.L....Licinio J. (2008)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    6. Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. (PubMed id 15534202)1, 2 Arnett K.L.... Wiley D.C. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)1, 2 Salomon A.R.... Peters E.C. (2003)
    9. Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. (PubMed id 9698567)1, 2 Fuetterer K.... Waksman G. (1998)
    10. Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11. (PubMed id 1671006)1, 4 Wong S....Demaine A.G. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 916 HGNC: 1674 AceView: CD3E Ensembl:ENSG00000198851 euGenes: HUgn916
    ECgene: CD3E Kegg: 916 H-InvDB: CD3E

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD3E Pharmacogenomics, SNPs, Pathways
    CD3Ebasehttp://bioinf.uta.fi/CD3Ebase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD3E

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD3E gene:
    Search GeneIP for patents involving CD3E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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