Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD3D Gene

protein-coding   GIFtS: 68
GCID: GC11M118212

CD3d Molecule, Delta (CD3-TCR Complex)

(Previous names: CD3d antigen, delta polypeptide (TiT3 complex))
(Previous symbol: T3D)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD3d Molecule, Delta (CD3-TCR Complex)1 2     CD3 Antigen, Delta Subunit2
T3D1 2 3 5     CD3 Delta2
CD3d Antigen, Delta Polypeptide (TiT3 Complex)1 2     OKT3, Delta Chain2
T-Cell Receptor T3 Delta Chain2 3     T-Cell Surface Glycoprotein CD3 Delta Chain2
CD3-DELTA2     CD3d Antigen3

External Ids:    HGNC: 16731   Entrez Gene: 9152   Ensembl: ENSG000001672867   OMIM: 1867905   UniProtKB: P042343   

Export aliases for CD3D gene to outside databases

Previous GC identifers: GC11M120566 GC11M119721 GC11M118239 GC11M117747 GC11M117714 GC11M114143


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD3D Gene:
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in
T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3
complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the
TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency
autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding
different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of
their transcripts has yet to be defined. (provided by RefSeq, Feb 2009)

GeneCards Summary for CD3D Gene: 
CD3D (CD3d molecule, delta (CD3-TCR complex)) is a protein-coding gene. Diseases associated with CD3D include cd3delta deficiency, and severe combined immune deficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive, cd3d-related, and among its related super-pathways are T cell receptor signaling pathway and Immune response IL-12-induced IFN-gamma production. GO annotations related to this gene include transmembrane signaling receptor activity and protein heterodimerization activity. An important paralog of this gene is CD3G.

UniProtKB/Swiss-Prot: CD3D_HUMAN, P04234
Function: The CD3 complex mediates signal transduction

Gene Wiki entry for CD3D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD3D gene promoter:
         TBP   RP58   NF-1/L   NF-1   POU3F2   GATA-1   TFIID   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD3D promoter sequence
   Search SABiosciences Chromatin IP Primers for CD3D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD3D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23

CD3D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD3D gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M118212:  view genomic region     (about GC identifiers)

Start:
118,209,669 bp from pter      End:
118,213,459 bp from pter
Size:
3,791 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD3D_HUMAN, P04234 (See protein sequence)
Recommended Name: T-cell surface glycoprotein CD3 delta chain precursor  
Size: 171 amino acids; 18930 Da
Subunit: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer
coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for CD3D:
1XIW (3D)    
Secondary accessions: A8MVP6
Alternative splicing: 2 isoforms:  P04234-1   P04234-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD3D: NX_P04234

Explore proteomics data for CD3D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04234

  • CD3D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD3D Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000723.1  NP_001035741.1  

    ENSEMBL proteins: 
     ENSP00000300692   ENSP00000434794   ENSP00000437335   ENSP00000376622  
    Reactome Protein details: P04234
    Human Recombinant Protein Products for CD3D: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CD3D
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CD3D
    GenScript Custom Purified and Recombinant Proteins Services for CD3D
    Novus Biologicals CD3D Proteins
    Novus Biologicals CD3D Lysates
    Sino Biological Recombinant Protein for CD3D
    Sino Biological Cell Lysate for CD3D 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS1831653
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0042101T cell receptor complex NAS9485181

    CD3D for ontologies           About GeneDecksing



    CD3D Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CD3D (TCR gamma/delta)
    OriGene Antibodies for CD3D
    OriGene Custom Antibody Services for CD3D
    GenScript Custom Superior Antibodies Services for CD3D
    Novus Biologicals CD3D Antibodies
    Abcam antibodies for CD3D
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CD3D
    LSBio Antibodies in human, mouse, rat for CD3D 

    Assay Products for CD3D: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD3D
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CD3D
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    4 InterPro protein domains:
     IPR015484 CD3_gsu/dsu
     IPR013783 Ig-like_fold
     IPR003110 Phos_immunorcpt_sig_ITAM
     IPR015485 CD3_delta

    Graphical View of Domain Structure for InterPro Entry P04234

    ProtoNet protein and cluster: P04234

    1 Blocks protein domain: IPB003110 Phosphorylated immunoreceptor signaling ITAM

    UniProtKB/Swiss-Prot: CD3D_HUMAN, P04234
    Similarity: Contains 1 ITAM domain


    CD3D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD3D_HUMAN, P04234
    Function: The CD3 complex mediates signal transduction

         Genatlas biochemistry entry for CD3D:
    cell differentiation antigen CD3D (gp20),20kDa,delta polypeptide (see CD3@)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA2017177
    GO:0004888transmembrane signaling receptor activity IC9485181
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity IPI9485181
         
    CD3D for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CD3D:
     Decreased viability of wild-ty 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd3d):
     cellular  hematopoietic system  immune system 

    CD3D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD3D: Cd3dtm1Kap Cd3d/Cd3gCd3d/tm1Cpt

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD3D 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD3D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD3D 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD3D 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD3D
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD3D
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD3D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD3D

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD3D
    Sirion Biotech Customized adenovirus for overexpression of CD3D

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CD3D (see all 11)
    OriGene ORF clones in mouse, rat for CD3D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD3D (NM_000732)
    Sino Biological Human cDNA Clone for CD3D
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD3D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD3D
    Sirion Biotech Customized lentivirus for stable overexpression of CD3D 
                         Customized lentivirus expression plasmids for stable overexpression of CD3D 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD3D
    Search LifeMap BioReagents cell lines for CD3D
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD3D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD3D About   (see all 42)                                                                                              See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway
    T cell receptor signaling pathway0.38
    TCR Signaling Pathway0.35
    2Immune response IL-12-induced IFN-gamma production
    Immune response IL-12-induced IFN-gamma production0.88
    IL12-mediated signaling events0.33
    3CD28 co-stimulation
    Costimulation by the CD28 family0.41
    CTLA4 Signaling0.31
    4Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.85
    PD-1 signaling0.77
    Phosphorylation of CD3 and TCR zeta chains0.85
    Generation of second messenger molecules0.64
    5ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    Calcium Mediated T-Cell Apoptosis0.31
    CD28 Signaling in T-Helper Cell0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/13 EMD Millipore Pathways for CD3D (see all 13)
        Immune response Antigen presentation by MHC class II
    Signal transduction IP3 signaling
    Immune response NFAT in immune response
    Immune response Antigen presentation by MHC class I
    Immune response CD28 signaling

    1 R&D Systems Pathway for CD3D
        IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

    5/20 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD3D (see all 20)
        Calcium Mediated T-Cell Apoptosis
    Nur77 Signaling in T-Cell
    NFAT Signaling and Lymphocyte Interactions
    CTL Mediated Apoptosis
    Tec Kinases Signaling

    5/13 GeneGo (Thomson Reuters) Pathways for CD3D (see all 13)
        G-protein signaling Regulation of RAC1 activity
    Immune response Antigen presentation by MHC class II
    Immune response CD28 signaling
    Immune response IL-12-induced IFN-gamma production
    G-protein signaling N-RAS regulation pathway

    5/7 BioSystems Pathways for CD3D (see all 7)
        TCR Signaling Pathway
    Downstream signaling in naive CD8+ T cells
    TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD8+ T cells
    IL12-mediated signaling events


    5/10        Reactome Pathways for CD3D (see all 10)
        Costimulation by the CD28 family
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Translocation of ZAP-70 to Immunological synapse
    Downstream TCR signaling


    5/6         Kegg Pathways  (Kegg details for CD3D) (see all 6):
        Hematopoietic cell lineage
    T cell receptor signaling pathway
    Chagas disease (American trypanosomiasis)
    Measles
    HTLV-I infection


    CD3D for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD3D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/85 Interacting proteins for CD3D (P042342, 3 ENSP000003006924) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR3C1P041502, 3, ENSP000002315094MINT-3374054 I2D: score=1 STRING: ENSP00000231509
    CD3EP077663, ENSP000003545664I2D: score=3 STRING: ENSP00000354566
    CD247P209633, ENSP000003547824I2D: score=2 STRING: ENSP00000354782
    DERL1Q9BUN83, ENSP000002595124I2D: score=1 STRING: ENSP00000259512
    UBA52P629873, ENSP000003881074I2D: score=1 STRING: ENSP00000388107
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway IC9485181
    GO:0030217T cell differentiation IDA2017177
    GO:0031295T cell costimulation TAS--
    GO:0045059positive thymic T cell selection ISS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA2017177

    CD3D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD3D

    1 DrugBank Compound for CD3D    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MuromonabAntiCD3 (see all 2)140608-64-6target--2503348 8861551

    Search CenterWatch for drugs/clinical trials and news about CD3D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD3D gene (2 alternative transcripts): 
    NM_000732.4  NM_001040651.1  

    Unigene Cluster for CD3D:

    CD3d molecule, delta (CD3-TCR complex)
    Hs.504048  [show with all ESTs]
    Unigene Representative Sequence: AK093775
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300692(uc001pss.1 uc001pst.1 uc021qrf.1) ENST00000534687
    ENST00000529594 ENST00000392884 ENST00000526561
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD3D
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD3D
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD3D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD3D
    Clone
    Products:
         
    OriGene clones in human, mouse for CD3D (see all 11)
    OriGene ORF clones in mouse, rat for CD3D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD3D (NM_000732)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD3D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD3D
    Sirion Biotech Customized lentivirus for stable overexpression of CD3D 
                         Customized lentivirus expression plasmids for stable overexpression of CD3D 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD3D
    OriGene qSTAR qPCR primer pairs in human, mouse for CD3D
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD3D
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD3D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD3D

    Additional mRNA sequence: 

    AK093775.1 AK311971.1 BC039035.1 BC070321.1 JN392069.1 

    11 DOTS entries:

    DT.452691  DT.100770582  DT.92424063  DT.40277577  DT.91903835  DT.92424060  DT.100722753  DT.100747237 
    DT.86847456  DT.70102502  DT.92415865 

    24/101 AceView cDNA sequences (see all 101):

    CR599233 AA381986 AA310933 AU185867 CD014060 BC070321 BP431347 AA381899 
    AA306478 AA381434 CD014059 AA934361 CN478514 CD014058 NM_000732 BP431080 
    AA354873 AA381994 BC039035 BP431337 CR611428 AW628585 BX093175 AW593115 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CD3D    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                    -                     
    SP3:              -                           
    SP4:              -     -                     


    ECgene alternative splicing isoforms for CD3D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD3D expression in normal human tissues (normalized intensities)      CD3D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTGGAAG
    CD3D Expression
    About this image


    CD3D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Peripheral blood-derived hematopoietic stem cells
             Peripheral blood Pan-T Cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Endothelial Cells Blood Brain Barrier
             Peripheral blood-derived endothelial progenitor cells
             blood vessel   
     
     Lymph (Hematopoietic System)    fully expand to see all 3 entries
             lymph node ; non-germinal center cells   
             Lymphnode   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Umbilical cord blood-derived endothelial progenitor cells
             Cord Blood CD133- Cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   

    See CD3D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD3D

    SOURCE GeneReport for Unigene cluster: Hs.504048
        SABiosciences Expression via Pathway-Focused PCR Arrays including CD3D: 
              Cell Surface Markers in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Stem Cells in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CD3D
    OriGene qSTAR qPCR primer pairs in human, mouse for CD3D
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD3D
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD3D
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD3D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD3D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD3D gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd3d1 , 5 CD3 antigen, delta polypeptide1, 5 75.24(n)1
    64.33(a)1
      9 (24.84 cM)5
    125001  NM_013487.31  NP_038515.31 
     449817935 
    chicken
    (Gallus gallus)
    Aves CD3D1 CD3d molecule, delta (CD3-TCR complex) 56.85(n)
    45.89(a)
      396518  NM_205512.1  NP_990843.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    1 → many
    GL343767.1(93549-102143)


    ENSEMBL Gene Tree for CD3D (if available)
    TreeFam Gene Tree for CD3D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD3D gene
    CD3G2  
    1 SIMAP similar gene for CD3D using alignment to 5 protein entries:     CD3D_HUMAN (see all proteins):
    CD3G

    CD3D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/137 SNPs in CD3D are shown (see all 137)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1110335811,2
    Cpathogenic1118074325(-) GTGTGA/CCAGAG 3 * C stg1 int10--------
    rs1110335801,2
    Cpathogenic1118074870(-) ACCCAA/C/TGAGGA 4 R * stg10--------
    rs1939226171,2
    Cunknown1118073870(-) GTGAGC/TGTTGA 2 -- int10--------
    rs1501842611,2
    C--118073049(+) GGGCCA/GTAGAG 2 -- ds50010--------
    rs1390472071,2
    --118073073(+) CTTAGC/GAGCAG 2 -- ds50010--------
    rs1430632531,2
    --118073294(+) GGTGGC/TGCAGA 2 -- ds50010--------
    rs122765581,2
    H--118073376(+) ACTGTC/GTGTGT 2 -- ds50014Minor allele frequency- G:0.00NS EA 386
    rs1872075311,2
    --118073394(+) AGGAAA/GGAAGG 2 -- ds50010--------
    rs1928879911,2
    --118073463(+) CCCACA/GCCTTG 2 -- ds50010--------
    rs1132714621,2
    C--118073528(+) TGGCTG/AAGCAA 2 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for CD3D (118209669 - 118213459 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CD3D: --

    Human Gene Mutation Database (HGMD): CD3D

    Locus Specific Mutation Databases (LSDB): CD3D
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD3D
    DNA2.0 Custom Variant and Variant Library Synthesis for CD3D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 186790   
    OMIM disorders: 608971  
    UniProtKB/Swiss-Prot: CD3D_HUMAN, P04234
  • Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive
    (T(-)B(+)NK(+) SCID) [MIM:608971]: A form of severe combined immunodeficiency (SCID), a genetically and
    clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and
    cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent,
    persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of
    T-cell-mediated cellular immunity due to a defect in T-cell development. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 20/29 diseases for CD3D (see all 29):    About MalaCards
    cd3delta deficiency    severe combined immune deficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive, cd3d-related    viral pneumonia    severe combined immunodeficiency
    keratoacanthoma    trypanosomiasis    chagas disease    leukopenia
    measles    eosinophilia    pneumonia    allergic rhinitis
    basal cell carcinoma    rhinitis    aplastic anemia    multiple myeloma
    hiv type 1    osteoarthritis    myeloma    influenza

    2 diseases from the University of Copenhagen DISEASES database for CD3D:
    Severe combined immunodeficiency     Viral pneumonia

    CD3D for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for CD3D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    severe combined immunodeficiency 65 5 15729559 (4), 17291425 (1)
    diabetes mellitus insulin-dependent 18.4 1 1982251 (1)
    necrosis 0 1 10886141 (1)

    Genetic Association Database (GAD): CD3D
    Human Genome Epidemiology (HuGE) Navigator: CD3D (4 documents)

    Export disorders for CD3D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD3D gene, integrated from 9 sources (see all 136):
    (articles sorted by number of sources associating them with CD3D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of 6 candidate genes on chromosome 11q23 f or coeliac disease susceptibility: a case control study. (PubMed id 20478055)1, 4 Brophy K....McManus R. (2010)
    2. A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis. (PubMed id 19222422)1, 4 Benson M....Cardell L.O. (2009)
    3. PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. (PubMed id 15028279)1, 2 Jin P.... Stuve L.L. (2004)
    4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    5. Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. (PubMed id 15534202)1, 2 Arnett K.L.... Wiley D.C. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)1, 2 Salomon A.R.... Peters E.C. (2003)
    8. Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. (PubMed id 14602880)1, 2 Dadi H.K.... Roifman C.M. (2003)
    9. Dephosphorylation of the human T lymphocyte CD3 antigen. (PubMed id 2540970)1, 2 Alexander D....Crumpton M.J. (1989)
    10. T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells. (PubMed id 3488209)1, 2 Tunnacliffe A.... Rabbitts T.H. (1986)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 915 HGNC: 1673 AceView: CD3D Ensembl:ENSG00000167286 euGenes: HUgn915
    ECgene: CD3D Kegg: 915 H-InvDB: CD3D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD3D Pharmacogenomics, SNPs, Pathways
    CD3Dbasehttp://bioinf.uta.fi/CD3Dbase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD3D

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD3D gene:
    Search GeneIP for patents involving CD3D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CD3D (TCR gamma/delta)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CD3D   OriGene RNAi products in human, mouse, rat for CD3D  
     OriGene qPCR primer pairs and template standards for CD3D   OriGene Protein Over-expression Lysate for CD3D  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CD3D  
     OriGene qSTAR qPCR primer pairs in human, mouse for CD3D   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CD3D   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CD3D   OriGene Custom Protein Services for CD3D  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD3D
     QIAGEN SeqTarget long-range PCR primers for resequencing CD3D
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD3D
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD3D
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD3D
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD3D
     GenScript Custom Purified and Recombinant Proteins Services for CD3D GenScript cDNA clones with any tag delivered in your preferred vector for CD3D
     GenScript Custom Assay Services for CD3D GenScript Custom Superior Antibodies Services for CD3D
     GenScript Custom overexpressing Cell Line Services for CD3D CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CD3D promoter
     Search Chromatin IP Primers for CD3D
     RT2 qPCR Primer Assay in human, mouse, rat CD3D
     GNC Network for CD3D
     SABiosciences PCR Arrays including human, mouse, rat CD3D
     Search Tocris compounds for CD3D
     Proteins and Antibodies for CD3D
     Cell Lysates for CD3D
     cDNA Clones for CD3D
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CD3D antibodies
     CD3D proteins
     CD3D lysates
     Antibodies for CD3D
     See all of Abcam's Antibodies, Kits and Proteins for CD3D
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CD3D
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD3D
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CD3D
     SwitchGear Promoter luciferase reporter plasmids for CD3D
     ThermoFisher Antibody for CD3D
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD3D
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CD3D
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD3D
    Customized:
     lentivirus for stable overexpression of CD3D
     lentivirus expression plasmids for stable overexpression of CD3D
     adenovirus for overexpression of CD3D
     LSBio Antibodies in human, mouse, rat for CD3D
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CD3D gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4