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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD3D Gene

protein-coding GIFtS: 67
GCID: GC11M118212

CD3d molecule, delta (CD3-TCR complex)

(Previous names: CD3d antigen, delta polypeptide (TiT3 complex) )
(Previous symbol: T3D)

Explore 25 diseases affiliated with
CD3D via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD3d Molecule, Delta (CD3-TCR Complex)¹ ²		CD3 Antigen, Delta Subunit²
T3D¹ ² ³ ⁵		CD3 Delta²
CD3d Antigen, Delta Polypeptide (TiT3 Complex)¹ ²		OKT3, Delta Chain²
T-Cell Receptor T3 Delta Chain² ³		T-Cell Surface Glycoprotein CD3 Delta Chain²
CD3-DELTA²		CD3d Antigen³

External Ids:	HGNC: 1673¹	Entrez Gene: 915²	Ensembl: ENSG00000167286⁷	OMIM: 186790⁵	UniProtKB: P04234³

Export aliases for CD3D gene to outside databases

Previous GC identifers: GC11M120566 GC11M119721 GC11M118239 GC11M117747 GC11M117714 GC11M114143

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD3D:

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell

development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and

along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the

surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive

T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have

been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to

be defined. (provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: CD3D_HUMAN, P04234

Function: The CD3 complex mediates signal transduction

Gene Wiki entry for CD3D

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD3D gene promoter:
TBP RP58 NF-1/L NF-1 POU3F2 GATA-1 TFIID En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD3D promoter sequence

Search SABiosciences Chromatin IP Primers for CD3D

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD3D

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23

CD3D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD3D gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M118212: view genomic region (about GC identifiers)

Start:	118,209,669 bp from pter	End:	118,213,459 bp from pter
Size:	3,791 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD3D_HUMAN, P04234 (See protein sequence)

Recommended Name: T-cell surface glycoprotein CD3 delta chain precursor

Size: 171 amino acids; 18930 Da

Subunit: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer

coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta

Subcellular location: Membrane; Single-pass type I membrane protein

1 PDB 3D structure from and Proteopedia for CD3D:

1XIW (3D)

Secondary accessions: A8MVP6

Alternative splicing: 2 isoforms: P04234-1 P04234-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD3D: NX_P04234

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04234

CD3D Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000723.1 NP_001035741.1

ENSEMBL proteins:

ENSP00000300692 ENSP00000434794 ENSP00000437335 ENSP00000376622

Reactome Protein details: P04234
Human Recombinant Protein Products:

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	Novus Biologicals CD3D Proteins Novus Biologicals CD3D Lysates
	Sino Biological Recombinant Protein for CD3D
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	1831653
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--
GO:0042101	T cell receptor complex	NAS	9485181

CD3D for ontologies About GeneDecksing

CD3D Antibody Products:

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Assay Products for CD3D:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD3D for domains About GeneDecksing

4 InterPro domains/families:

IPR015484 CD3_gsu/dsu

IPR013783 Ig-like_fold

IPR003110 Phos_immunorcpt_sig_ITAM

IPR015485 CD3_delta

Graphical View of Domain Structure for InterPro Entry P04234

ProtoNet protein and cluster: P04234

1 Blocks protein family: IPB003110 Phosphorylated immunoreceptor signaling ITAM

UniProtKB/Swiss-Prot: CD3D_HUMAN, P04234

Similarity: Contains 1 ITAM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CD3D_HUMAN, P04234

Function: The CD3 complex mediates signal transduction

Genatlas biochemistry entry for CD3D:

cell differentiation antigen CD3D (gp20),20kDa,delta polypeptide (see CD3@)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD3D Browse MicroRNA Expression Plasmids
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD3D

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CD3D

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD3D
		Search LifeMap BioReagents cell lines for CD3D

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD3D

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	IDA	2017177
GO:0004888	transmembrane signaling receptor activity	IC	9485181
GO:0005515	protein binding	--	--
GO:0046982	protein heterodimerization activity	IPI	9485181

CD3D for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CD3D:

Decreased viability of wild-ty

Animal Models:
Mouse knock-outs for CD3D: Cd3d^tm1Kap Cd3d/Cd3g^Cd3d/tm1Cpt
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd3d):

cellular

hematopoietic system

immune system

CD3D for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/41 super-pathways (see all 41) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translocation of ZAP-70 to Immunological synapse

	Translocation of ZAP-70 to Immunological synapse	1.00			PD-1 signaling	0.76
	Phosphorylation of CD3 and TCR zeta chains	0.85			Generation of second messenger molecules	0.64

Immune response IL-12-induced IFN-gamma production

	Immune response IL-12-induced IFN-gamma production	1.00			IL12-mediated signaling events	0.33
	Immune response_IL-12-induced IFN-gamma production	0.88

ICos-ICosL Pathway in T-Helper Cell

	ICos-ICosL Pathway in T-Helper Cell	1.00			Calcium Mediated T-Cell Apoptosis	0.31
	CD28 Signaling in T-Helper Cell	0.66

PKC-Theta Pathway

	PKC-Theta Pathway	1.00			ITK and TCR Signaling	0.54
	TCR Signaling	0.68

Immune response_NFAT in immune response

Immune response_NFAT in immune response

1.00

Immune response NFAT in immune response

0.91

Pathway sources
See GeneCards unified pathways
Show all pathways

5/13 EMD Millipore Pathways for CD3D (see all 13)

	Immune response Antigen presentation by MHC class II
	Signal transduction IP3 signaling
	Immune response NFAT in immune response
	Immune response Antigen presentation by MHC class I
	Immune response CD28 signaling

1 R&D Systems Pathway for CD3D

IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types

5/20 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CD3D (see all 20)

	Calcium Mediated T-Cell Apoptosis
	Nur77 Signaling in T-Cell
	NFAT Signaling and Lymphocyte Interactions
	CTL Mediated Apoptosis
	Tec Kinases Signaling

5/13 GeneGo (Thomson Reuters) Pathways for CD3D (see all 13)

	G-protein signaling Regulation of RAC1 activity
	Immune response Antigen presentation by MHC class II
	Immune response CD28 signaling
	Immune response IL-12-induced IFN-gamma production
	G-protein signaling N-RAS regulation pathway

5/7 BioSystems Pathways for CD3D (see all 7)

	TCR Signaling Pathway
	IL12-mediated signaling events
	TCR signaling in naive CD8+ T cells
	TCR signaling in naive CD4+ T cells
	CXCR4-mediated signaling events

5/10 Reactome Pathways for CD3D (see all 10)

	Costimulation by the CD28 family
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Adaptive Immune System
	Translocation of ZAP-70 to Immunological synapse
	Downstream TCR signaling

5 Kegg Pathways (Kegg details for CD3D):

	Hematopoietic cell lineage
	T cell receptor signaling pathway
	Chagas disease (American trypanosomiasis)
	Measles
	Primary immunodeficiency

CD3D for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD3D

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/85 Interacting proteins for CD3D (P04234^{2, 3} ENSP00000300692⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 85)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NR3C1	P04150²^,³, ENSP00000231509⁴	MINT-3374054 I2D: score=1 STRING: ENSP00000231509
CD3E	P07766³, ENSP00000354566⁴	I2D: score=3 STRING: ENSP00000354566
CD247	P20963³, ENSP00000354782⁴	I2D: score=2 STRING: ENSP00000354782
DERL1	Q9BUN8³, ENSP00000259512⁴	I2D: score=1 STRING: ENSP00000259512
UBA52	P62987³, ENSP00000388107⁴	I2D: score=1 STRING: ENSP00000388107

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007166	cell surface receptor signaling pathway	IC	9485181
GO:0030217	T cell differentiation	IDA	2017177
GO:0031295	T cell costimulation	TAS	--
GO:0045059	positive thymic T cell selection	ISS	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	2017177

CD3D for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD3D

1 DrugBank Compound for CD3D About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Muromonab	AntiCD3 (see all 2)	140608-64-6	target	--	2503348 8861551

Search CenterWatch for drugs/clinical trials and news about CD3D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD3D gene (2 alternative transcripts):

NM_000732.4 NM_001040651.1

Unigene Cluster for CD3D:

CD3d molecule, delta (CD3-TCR complex)

Hs.504048 [show with all ESTs]

Unigene Representative Sequence: AK093775

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000300692(uc001pss.1 uc001pst.1 uc021qrf.1) ENST00000534687

ENST00000529594 ENST00000392884 ENST00000526561

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD3D Browse OriGene MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK093775.1 AK311971.1 BC039035.1 BC070321.1 JN392069.1

9 DOTS entries:

DT.452691 DT.100770582 DT.92424063 DT.40277577 DT.91903835 DT.92424060 DT.100722753 DT.100747237

DT.86847456

24/101 AceView cDNA sequences (see all 101):

AA381994 CD014058 CD014059 AA310933 CR599233 AU185867 BP431347 BP431337

NM_000732 AA306478 BP431080 AA381434 BC070321 AA381899 AA381986 AW628585

AA354873 AA934361 CD014060 CN478514 BC039035 BX093175 AW593115 CR611428

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CD3D About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b
SP1:
SP2:							-
SP3:					-
SP4:					-		-

ECgene alternative splicing isoforms for CD3D

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD3D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGACTGGAAG

About this image

CD3D expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CD3D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD3D

SOURCE GeneReport for Unigene cluster: Hs.504048

SABiosciences Expression via Pathway-Focused PCR Arrays including CD3D:

Cell Surface Markers in human mouse rat

Lymphoma in human mouse rat

T-cell & B-cell Activation in human mouse rat

Stem Cells in human mouse rat

Hematopoiesis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD3D

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD3D gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CD3D¹	CD3d molecule, delta (CD3-TCR complex)	56.85(n) 45.89(a)		396518 NM_205512.1 NP_990843.1
lizard (Anolis carolinensis)	Reptilia	--	--	36(a)	1 → many	GL343767.1(99052-102137)

ENSEMBL Gene Tree for CD3D (if available)
TreeFam Gene Tree for CD3D (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD3D gene

CD3G²

1 SIMAP similar gene for CD3D using alignment to 5 protein entries: CD3D_HUMAN (see all proteins):

CD3G

CD3D for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111033581^1,2	C	pathogenic	118210617(-)	`GTGTGA/CCAGAG`	3	* C	int¹ stg¹		0	--	--	--	--
rs111033580^1,2	C	pathogenic	118211162(-)	`ACCCAC/TGAGGA`	4	R *	stg¹		0	--	--	--	--
rs193922617^1,2	C	unknown	118210160(-)	`GTGAGC/TGTTGA`	2	--	int¹		0	--	--	--	--
rs12276558^1,2	H	--	114143560(+)	`ACTGTC/GTGTGT`	2	--	ds500¹		4		NS EA	386
rs113271462^1,2	C,	--	114143712(+)	`TGGCTG/AAGCAA`	2	--	ut3¹		1		CSA	2
rs146997233^1,2	C,F	--	114143777(+)	`CACTTG/ATTCCG`	4	/N	syn¹		2		NA EU	5867
rs141902449^1,2	C,F,	--	114147168(+)	`ACCTTG/TCGAGA`	1	--	us2k¹		1		NA	4550
rs76974878^1,2	C,	--	114147366(+)	`TCTGCC/GGTTGA`	1	--	us2k¹		2		WA	120
rs150657505^1,2	C,	--	114147377(+)	`TGGTGA/C/GGAAAT`	1	--	us2k¹		0	--	--	--	--
rs45621535^1,2	C,F	--	114148101(+)	`GATAGG/TGGCCT`	1	--	us2k¹		2		NS	14

HapMap Linkage Disequilibrium report for CD3D (118209669 - 118213459 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD3D: --
Human Gene Mutation Database (HGMD): CD3D

Locus Specific Mutation Databases (LSDB): CD3D

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD3D for disorders           About GeneDecksing

OMIM gene information: 186790
OMIM disorders: 608971
UniProtKB/Swiss-Prot: CD3D_HUMAN, P04234

Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive

T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined

immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized

by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients

present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types

of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development

20/25 diseases for CD3D (see all 25): About MalaCards

severe combined immunodeficiency combined immunodeficiency immunodeficiency allergic rhinitis

diabetes mellitus viral pneumonia basal cell carcinoma keratoacanthoma

rhinitis squamous cell carcinoma chagas disease leukopenia

multiple myeloma trypanosomiasis eosinophilia hepatitis b

measles myeloma pneumonia osteoarthritis

2 diseases from the University of Copenhagen DISEASES database for CD3D:

Severe combined immunodeficiency Viral pneumonia

3 Novoseek disease relationships for CD3D gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
severe combined immunodeficiency	65	5	15729559 (4), 17291425 (1)
diabetes mellitus insulin-dependent	18.4	1	1982251 (1)
necrosis	0	1	10886141 (1)

Human Genome Epidemiology (HuGE) Navigator: CD3D (4 documents)

Export disorders for CD3D gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD3D gene, integrated from 9 sources (see all 134):
(articles sorted by number of sources associating them with CD3D)

Utopia: connect your pdf to the dynamic
world of online information

PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. (PubMed id 15028279)^{1, 2} Jin P.... Stuve L.L. (2004)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. (PubMed id 15534202)^{1, 2} Arnett K.L.... Wiley D.C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. (PubMed id 12522270)^{1, 2} Salomon A.R.... Peters E.C. (2003)
Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. (PubMed id 14602880)^{1, 2} Dadi H.K.... Roifman C.M. (2003)
Dephosphorylation of the human T lymphocyte CD3 antigen. (PubMed id 2540970)^{1, 2} Alexander D....Crumpton M.J. (1989)
T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells. (PubMed id 3488209)^{1, 2} Tunnacliffe A.... Rabbitts T.H. (1986)
Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex. (PubMed id 2939461)^{1, 2} van den Elsen P....Terhorst C. (1986)
Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T- cell receptor complex. (PubMed id 6095101)^{1, 2} van den Elsen P.... Terhorst C. (1984)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 915	HGNC: 1673	AceView: CD3D	Ensembl:ENSG00000167286	euGenes: HUgn915
ECgene: CD3D	Kegg: 915	H-InvDB: CD3D

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD3D	Pharmacogenomics, SNPs, Pathways
CD3Dbase	http://bioinf.uta.fi/CD3Dbase/
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD3D

Intellectual Property for CD3D gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CD3D gene:
Search GeneIP for patents involving CD3D

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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