Aliases for CD3D Gene
External Ids for CD3D Gene
Previous Symbols for CD3D Gene
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
GeneCards Summary for CD3D Gene
CD3D (CD3d Molecule, Delta (CD3-TCR Complex)) is a Protein Coding gene. Diseases associated with CD3D include cd3delta deficiency and severe combined immune deficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive, cd3d-related. Among its related pathways are Class I MHC mediated antigen processing and presentation and Akt Signaling. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is CD3G.
UniProtKB/Swiss-Prot for CD3D Gene
The CD3 complex mediates signal transduction