Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD38 Gene

Aliases for CD38 Gene

  • CD38 Molecule 2 3
  • ADP-Ribosyl Cyclase 1 2 3 4
  • 2-Phospho-Cyclic-ADP-Ribose Transferase 3 4
  • Cyclic ADP-Ribose Hydrolase 1 3 4
  • 2-Phospho-ADP-Ribosyl Cyclase 3 4
  • NAD(+) Nucleosidase 2 3
  • CD38 Antigen (P45) 2 3
  • ADPRC 1 3 4
  • 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase 4
  • Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase 3
  • Cluster Of Differentiation 38 3
  • CADPr Hydrolase 1 4
  • CD38 Antigen 4
  • EC 2.4.99.20 4
  • EC 3.2.2.6 4
  • ADPRC1 3
  • T10 4

External Ids for CD38 Gene

Previous GeneCards Identifiers for CD38 Gene

  • GC04P015595
  • GC04P015722
  • GC04P015468
  • GC04P015530
  • GC04P015457
  • GC04P015130

Summaries for CD38 Gene

Entrez Gene Summary for CD38 Gene

  • The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for CD38 Gene

CD38 (CD38 Molecule) is a Protein Coding gene. Diseases associated with CD38 include b cell prolymphocytic leukemia and plica syndrome. Among its related pathways are Epstein-Barr virus infection and Metabolism. GO annotations related to this gene include transferase activity and hydrolase activity, acting on glycosyl bonds. An important paralog of this gene is BST1.

UniProtKB/Swiss-Prot for CD38 Gene

  • Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system

Gene Wiki entry for CD38 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD38 Gene

Genomics for CD38 Gene

Regulatory Elements for CD38 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD38 Gene

Chromosome:
4
Start:
15,778,275 bp from pter
End:
15,853,230 bp from pter
Size:
74,956 bases
Orientation:
Plus strand

Genomic View for CD38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CD38 Gene

Proteins for CD38 Gene

  • Protein details for CD38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28907-CD38_HUMAN
    Recommended name:
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    Protein Accession:
    P28907
    Secondary Accessions:
    • O00121
    • O00122
    • Q96HY4

    Protein attributes for CD38 Gene

    Size:
    300 amino acids
    Molecular mass:
    34328 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CD38 Gene

    Alternative splice isoforms for CD38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD38 Gene

Proteomics data for CD38 Gene at MOPED

Post-translational modifications for CD38 Gene

  • Glycosylation at Asn 100, Asn 164, Asn 209, and Asn 219
  • Modification sites at PhosphoSitePlus

Other Protein References for CD38 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD38 (CD38)

No data available for DME Specific Peptides for CD38 Gene

Domains & Families for CD38 Gene

Gene Families for CD38 Gene

Protein Domains for CD38 Gene

Suggested Antigen Peptide Sequences for CD38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28907

UniProtKB/Swiss-Prot:

CD38_HUMAN :
  • Belongs to the ADP-ribosyl cyclase family.
Family:
  • Belongs to the ADP-ribosyl cyclase family.
genes like me logo Genes that share domains with CD38: view

Function for CD38 Gene

Molecular function for CD38 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD38 (T10),45kDa,membrane glycoprotein,integral,identified by monoclonal antibody OKT10,HB-7,homolog to Aplysia ADRC gene,involved in insulin secretion through mobi-calcium of mobilisation
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
UniProtKB/Swiss-Prot CatalyticActivity:
NADP(+) + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.
UniProtKB/Swiss-Prot EnzymeRegulation:
ATP inhibits the hydrolyzing activity
UniProtKB/Swiss-Prot Function:
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system

Enzyme Numbers (IUBMB) for CD38 Gene

Gene Ontology (GO) - Molecular Function for CD38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003953 NAD+ nucleosidase activity IBA --
GO:0016740 transferase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds --
GO:0016849 phosphorus-oxygen lyase activity IBA --
GO:0050135 NAD(P)+ nucleosidase activity IEA --
genes like me logo Genes that share ontologies with CD38: view
genes like me logo Genes that share phenotypes with CD38: view

Animal Models for CD38 Gene

MGI Knock Outs for CD38:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD38

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CD38 Gene

Localization for CD38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD38 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD38 Gene COMPARTMENTS Subcellular localization image for CD38 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
endoplasmic reticulum 2
nucleus 2
cytoskeleton 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane TAS 8253715
genes like me logo Genes that share ontologies with CD38: view

Pathways & Interactions for CD38 Gene

genes like me logo Genes that share pathways with CD38: view

Pathways by source for CD38 Gene

1 GeneGo (Thomson Reuters) pathway for CD38 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CD38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0007165 signal transduction NAS 8253715
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007565 female pregnancy IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CD38: view

No data available for SIGNOR curated interactions for CD38 Gene

Drugs & Compounds for CD38 Gene

(28) Drugs for CD38 Gene - From: NovoSeek, HMDB, DGIdb, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Lenalidomide Approved Pharma Anti-angiogenic. 652
Pomalidomide Approved Pharma 98
Fludarabine Approved Pharma DNA synthsis inhibitor 1008
rituximab Approved Pharma Therapeutic Antibodies 1514

(23) Additional Compounds for CD38 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
(E)-3-(2,3-Dihydroxyphenyl)-2-propenoic acid
  • ADPribose 2'-phosphate
  • APX
38481-04-8
Adenosine diphosphate ribose
  • (Rib5)ppA
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • A5'pp5Rib
  • Adenosine 5'-diphosphoribose
  • Adenosine diphosphate ribose
20762-30-5
ADP-ribose 2'-phosphate
  • 2'-Phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate]
  • ADP-D-Ribose 2'-phosphate
  • ADPribose 2'-phosphate
26303-90-2
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with CD38: view

Transcripts for CD38 Gene

Unigene Clusters for CD38 Gene

CD38 molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD38

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD38 Gene

No ASD Table

Relevant External Links for CD38 Gene

GeneLoc Exon Structure for
CD38
ECgene alternative splicing isoforms for
CD38

Expression for CD38 Gene

mRNA expression in normal human tissues for CD38 Gene

mRNA differential expression in normal tissues according to GTEx for CD38 Gene

This gene is overexpressed in Spleen (x5.8).

Protein differential expression in normal tissues from HIPED for CD38 Gene

This gene is overexpressed in Seminal vesicle (11.0), Stomach (9.4), Oral epithelium (9.1), and NK cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD38 Gene



SOURCE GeneReport for Unigene cluster for CD38 Gene Hs.479214

mRNA Expression by UniProt/SwissProt for CD38 Gene

P28907-CD38_HUMAN
Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
genes like me logo Genes that share expression patterns with CD38: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CD38 Gene

Orthologs for CD38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD38 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CD38 35
  • 73.87 (n)
  • 59.12 (a)
CD38 36
  • 47 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd38 35
  • 72.3 (n)
  • 59.8 (a)
Cd38 16
Cd38 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD38 35
  • 99.33 (n)
  • 99 (a)
CD38 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd38 35
  • 72.75 (n)
  • 59.46 (a)
cow
(Bos Taurus)
Mammalia CD38 36
  • 43 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD38 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD38 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD38 35
  • 60.73 (n)
  • 47.77 (a)
CD38 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd38 35
  • 52.36 (n)
  • 40.89 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101886891 35
  • 48.65 (n)
  • 34.68 (a)
CR318624.1 36
  • 30 (a)
OneToMany
Species with no ortholog for CD38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD38 Gene

ENSEMBL:
Gene Tree for CD38 (if available)
TreeFam:
Gene Tree for CD38 (if available)

Paralogs for CD38 Gene

Paralogs for CD38 Gene

(1) SIMAP similar genes for CD38 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD38: view

Variants for CD38 Gene

Sequence variations from dbSNP and Humsavar for CD38 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_001323 -

Structural Variations from Database of Genomic Variants (DGV) for CD38 Gene

Variant ID Type Subtype PubMed ID
nsv10460 CNV Loss 18304495
nsv878714 CNV Loss 21882294
nsv878715 CNV Loss 21882294
esv2676893 CNV Deletion 23128226
nsv527861 CNV Gain 19592680

Variation tolerance for CD38 Gene

Residual Variation Intolerance Score: 82.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD38 Gene

HapMap Linkage Disequilibrium report
CD38
Human Gene Mutation Database (HGMD)
CD38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD38 Gene

Disorders for CD38 Gene

MalaCards: The human disease database

(32) MalaCards diseases for CD38 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
b cell prolymphocytic leukemia
  • leukemia, b cell prolymphocytic
plica syndrome
encapsulated thymoma
richter's syndrome
  • richter syndrome
invasive malignant thymoma
  • infiltrating thymoma
- elite association
Search CD38 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD38

Genetic Association Database (GAD)
CD38
Human Genome Epidemiology (HuGE) Navigator
CD38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD38
genes like me logo Genes that share disorders with CD38: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD38 Gene

Publications for CD38 Gene

  1. Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. (PMID: 9074508) Nata K. … Okamoto H. (Gene 1997) 2 23 67
  2. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. (PMID: 2319135) Jackson D.G. … Bell J.I. (J. Immunol. 1990) 2 23 67
  3. TLR2 utilization of Borrelia does not induce p38- and IFN-beta autocrine loop-dependent expression of CD38, resulting in poor migration and weak IL-12 secretion of dendritic cells. (PMID: 20393136) Hartiala P. … Viljanen M.K. (J. Immunol. 2010) 23 67
  4. A single tube, four-color flow cytometry assay for evaluation of ZAP-70 and CD38 expression in chronic lymphocytic leukemia. (PMID: 20395517) Hassanein N.M. … Lagoo A.S. (Am. J. Clin. Pathol. 2010) 23 67
  5. Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38. (PMID: 19640843) Graeff R. … Lee H.C. (J. Biol. Chem. 2009) 23 67

Products for CD38 Gene

Sources for CD38 Gene

Back to Top

Content