Aliases for CD38 Gene
External Ids for CD38 Gene
Previous GeneCards Identifiers for CD38 Gene
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
GeneCards Summary for CD38 Gene
CD38 (CD38 Molecule) is a Protein Coding gene. Diseases associated with CD38 include b cell prolymphocytic leukemia and plica syndrome. Among its related pathways are Epstein-Barr virus infection and Metabolism. GO annotations related to this gene include transferase activity and hydrolase activity, acting on glycosyl bonds. An important paralog of this gene is BST1.
UniProtKB/Swiss-Prot for CD38 Gene
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system