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Aliases for CD38 Gene

Aliases for CD38 Gene

  • CD38 Molecule 2 3 5
  • ADP-Ribosyl Cyclase 1 2 3 4
  • 2-Phospho-Cyclic-ADP-Ribose Transferase 3 4
  • Cyclic ADP-Ribose Hydrolase 1 3 4
  • 2-Phospho-ADP-Ribosyl Cyclase 3 4
  • NAD(+) Nucleosidase 2 3
  • CD38 Antigen (P45) 2 3
  • ADPRC 1 3 4
  • 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase 4
  • Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase 3
  • ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1 3
  • Cluster Of Differentiation 38 3
  • CADPr Hydrolase 1 4
  • CD38 Antigen 4
  • EC 4
  • EC 4
  • ADPRC1 3
  • T10 4

External Ids for CD38 Gene

Previous GeneCards Identifiers for CD38 Gene

  • GC04P015595
  • GC04P015722
  • GC04P015468
  • GC04P015530
  • GC04P015457
  • GC04P015130

Summaries for CD38 Gene

Entrez Gene Summary for CD38 Gene

  • The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for CD38 Gene

CD38 (CD38 Molecule) is a Protein Coding gene. Diseases associated with CD38 include Chronic Lymphocytic Leukemia and Richter's Syndrome. Among its related pathways are Hematopoietic cell lineage and Calcium signaling pathway. GO annotations related to this gene include transferase activity and hydrolase activity, acting on glycosyl bonds. An important paralog of this gene is BST1.

UniProtKB/Swiss-Prot for CD38 Gene

  • Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Gene Wiki entry for CD38 Gene

Additional gene information for CD38 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD38 Gene

Genomics for CD38 Gene

Regulatory Elements for CD38 Gene

Enhancers for CD38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H015753 1.6 FANTOM5 Ensembl ENCODE dbSUPER 34.1 -22.9 -22862 4.4 CTCF STAT1 JUN NR2F1 MAX DPF2 RAD21 NR2F2 POLR2A IKZF1 CD38 RPL10AP7 TAPT1 FBXL5 LOC100288771
GH04H015778 1.5 FANTOM5 ENCODE dbSUPER 22.1 +0.9 944 2.3 FOXA2 TBL1XR1 SIN3A RAD21 YY1 SCRT2 ZNF207 ETV6 RUNX3 IKZF2 CD38 FBXL5 BST1 GC04M015778 GC04P015792
GH04H015774 1.1 FANTOM5 ENCODE dbSUPER 21.8 -3.9 -3943 0.3 RFX1 USF2 CEBPB NR3C1 PRDM1 CD38 FGFBP2 LOC100288771
GH04H015808 1.1 FANTOM5 Ensembl 21.2 +30.9 30926 1.2 HDGF TBL1XR1 BACH1 BMI1 BATF RELA ATF7 RUNX3 IKZF2 CHD2 CD38 FGFBP2 PROM1 BST1 GC04P015792 PIR31595
GH04H015764 1 Ensembl ENCODE dbSUPER 20.8 -12.1 -12093 2.4 EED IKZF1 RUNX3 IKZF2 CD38 LOC100288771
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD38 on UCSC Golden Path with GeneCards custom track

Promoters for CD38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000166241 825 1401 FOXA2 TBL1XR1 SIN3A BATF RAD21 YY1 SCRT2 ZNF207 ETV6 RUNX3

Genomic Locations for CD38 Gene

Genomic Locations for CD38 Gene
74,956 bases
Plus strand

Genomic View for CD38 Gene

Genes around CD38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD38 Gene

Proteins for CD38 Gene

  • Protein details for CD38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    Protein Accession:
    Secondary Accessions:
    • O00121
    • O00122
    • Q96HY4

    Protein attributes for CD38 Gene

    300 amino acids
    Molecular mass:
    34328 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CD38 Gene

    Alternative splice isoforms for CD38 Gene


neXtProt entry for CD38 Gene

Post-translational modifications for CD38 Gene

  • Glycosylation at posLast=100100, posLast=164164, posLast=209209, and Asn219
  • Modification sites at PhosphoSitePlus

Other Protein References for CD38 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Abcam proteins for CD38

No data available for DME Specific Peptides for CD38 Gene

Domains & Families for CD38 Gene

Gene Families for CD38 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CD38 Gene

Suggested Antigen Peptide Sequences for CD38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ADP-ribosyl cyclase family.
  • Belongs to the ADP-ribosyl cyclase family.
genes like me logo Genes that share domains with CD38: view

Function for CD38 Gene

Molecular function for CD38 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD38 (T10),45kDa,membrane glycoprotein,integral,identified by monoclonal antibody OKT10,HB-7,homolog to Aplysia ADRC gene,involved in insulin secretion through mobi-calcium of mobilisation
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
UniProtKB/Swiss-Prot CatalyticActivity:
NADP(+) + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.
UniProtKB/Swiss-Prot EnzymeRegulation:
ATP inhibits the hydrolyzing activity.
UniProtKB/Swiss-Prot Function:
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Enzyme Numbers (IUBMB) for CD38 Gene

Phenotypes From GWAS Catalog for CD38 Gene

Gene Ontology (GO) - Molecular Function for CD38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003953 NAD+ nucleosidase activity TAS,IEA --
GO:0016740 transferase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0016849 phosphorus-oxygen lyase activity IBA,IEA --
genes like me logo Genes that share ontologies with CD38: view
genes like me logo Genes that share phenotypes with CD38: view

Animal Models for CD38 Gene

MGI Knock Outs for CD38:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD38 Gene

Localization for CD38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD38 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD38 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 3
mitochondrion 2
endoplasmic reticulum 2
cytoskeleton 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0009986 cell surface IEA --
GO:0016020 membrane TAS 8253715
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD38: view

Pathways & Interactions for CD38 Gene

genes like me logo Genes that share pathways with CD38: view

Gene Ontology (GO) - Biological Process for CD38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0007165 signal transduction NAS 8253715
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007565 female pregnancy IEA --
GO:0009725 response to hormone IEA --
genes like me logo Genes that share ontologies with CD38: view

No data available for SIGNOR curated interactions for CD38 Gene

Drugs & Compounds for CD38 Gene

(49) Drugs for CD38 Gene - From: DrugBank, ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daratumumab Approved Pharma Target, antibody 69
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist 2239
Nicotinamide Approved Nutra 937,941
Lenalidomide Approved Pharma Anti-angiogenic. 753
Pomalidomide Approved Pharma 138

(21) Additional Compounds for CD38 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
(E)-3-(2,3-Dihydroxyphenyl)-2-propenoic acid
  • ADPribose 2'-phosphate
  • APX
Adenosine diphosphate ribose
  • (Rib5)ppA
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • A5'pp5Rib
  • Adenosine 5'-diphosphoribose
  • Adenosine diphosphate ribose
ADP-ribose 2'-phosphate
  • 2'-Phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate]
  • ADP-D-Ribose 2'-phosphate
  • ADPribose 2'-phosphate
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
genes like me logo Genes that share compounds with CD38: view

Transcripts for CD38 Gene

Unigene Clusters for CD38 Gene

CD38 molecule:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD38 Gene

No ASD Table

Relevant External Links for CD38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD38 Gene

mRNA differential expression in normal tissues according to GTEx for CD38 Gene

This gene is overexpressed in Spleen (x5.8).

Protein differential expression in normal tissues from HIPED for CD38 Gene

This gene is overexpressed in Seminal vesicle (11.0), Stomach (9.4), Oral epithelium (9.1), and NK cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD38 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD38 Gene:


SOURCE GeneReport for Unigene cluster for CD38 Gene:


mRNA Expression by UniProt/SwissProt for CD38 Gene:

Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Evidence on tissue expression from TISSUES for CD38 Gene

  • Liver(4.5)
  • Pancreas(4.3)
  • Bone marrow(3.6)
  • Blood(3.5)
  • Lymph node(3.3)
  • Spleen(3.1)
  • Lung(2.4)
  • Nervous system(2.4)
  • Heart(2.3)
  • Intestine(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with CD38: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD38 Gene

Orthologs for CD38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD38 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD38 33 34
  • 99.33 (n)
(Canis familiaris)
Mammalia CD38 33 34
  • 73.87 (n)
(Rattus norvegicus)
Mammalia Cd38 33
  • 72.75 (n)
(Mus musculus)
Mammalia Cd38 33 16 34
  • 72.3 (n)
(Monodelphis domestica)
Mammalia CD38 34
  • 47 (a)
(Bos Taurus)
Mammalia CD38 34
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia CD38 34
  • 42 (a)
(Gallus gallus)
Aves CD38 33 34
  • 60.73 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd38 33
  • 52.36 (n)
(Danio rerio)
Actinopterygii LOC101886891 33
  • 48.65 (n)
CR318624.1 34
  • 30 (a)
Species where no ortholog for CD38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD38 Gene

Gene Tree for CD38 (if available)
Gene Tree for CD38 (if available)

Paralogs for CD38 Gene

Paralogs for CD38 Gene

(1) SIMAP similar genes for CD38 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD38: view

Variants for CD38 Gene

Sequence variations from dbSNP and Humsavar for CD38 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000004314 -- 15,839,483(+) CAGTG(-/AC)ACGGT intron-variant
rs1000036999 -- 15,839,191(+) AAGCA(C/T)TAACA intron-variant
rs1000094121 -- 15,784,394(+) AAAAT(C/T)CTGGC intron-variant
rs1000161595 -- 15,785,322(+) GCCCC(C/T)AGAGT intron-variant
rs1000189637 -- 15,819,704(+) AAAAA(G/T)AATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD38 Gene

Variant ID Type Subtype PubMed ID
nsv527861 CNV gain 19592680
nsv10460 CNV loss 18304495
esv3893885 CNV loss 25118596
esv2676893 CNV deletion 23128226
dgv5145n100 CNV gain 25217958

Variation tolerance for CD38 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD38 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD38 Gene

Disorders for CD38 Gene

MalaCards: The human disease database

(34) MalaCards diseases for CD38 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic lymphocytic leukemia
  • b-cell chronic lymphocytic leukemia
richter's syndrome
  • richter syndrome
plica syndrome
encapsulated thymoma
prolymphocytic leukemia
  • leukemia prolymphocytic
- elite association - COSMIC cancer census association via MalaCards
Search CD38 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD38

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CD38: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD38 Gene

Publications for CD38 Gene

  1. A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro. (PMID: 9754820) Yagui K … Kanatsuka A (Diabetologia 1998) 3 4 22 45 60
  2. Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. (PMID: 9074508) Nata K … Okamoto H (Gene 1997) 2 3 4 22 60
  3. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. (PMID: 2319135) Jackson DG … Bell JI (Journal of immunology (Baltimore, Md. : 1950) 1990) 2 3 4 22 60
  4. CD38 gene polymorphisms contribute to genetic susceptibility to B-cell chronic lymphocytic leukemia: evidence from two case-control studies in Polish Caucasians. (PMID: 19240243) Jamroziak K … Robak T (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 45 60
  5. CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome? (PMID: 18424664) Aydin S … Deaglio S (Blood 2008) 3 22 45 60

Products for CD38 Gene

Sources for CD38 Gene

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