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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD38 Gene

protein-coding   GIFtS: 65
GCID: GC04P015779

CD38 molecule

(Previous name: CD38 antigen (p45) )
 Explore 50 diseases affiliated with
CD38 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CD38    

Aliases
for CD38 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CD38 Molecule1 2     ADP-Ribosyl Cyclase 12
CD38 Antigen (P45)1 2     ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase2
Cyclic ADP-Ribose Hydrolase 12 3     NAD(+) Nucleosidase2
T102 3     EC 3.2.2.53
CADPr Hydrolase 12 3     CD38 Antigen3

External Ids:    HGNC: 16671   Entrez Gene: 9522   Ensembl: ENSG000000044687   OMIM: 1072705   UniProtKB: P289073   

Export aliases for CD38 gene to outside databases

Previous GC identifers: GC04P015595 GC04P015722 GC04P015468 GC04P015530 GC04P015457 GC04P015130


Summaries
for CD38 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CD38:
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also
functions in cell adhesion,signal transduction and calcium signaling. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr
hydrolase activity. Also moonlights as a receptor in cells of the immune system

Gene Wiki entry for CD38


Genomic Views
for CD38 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD38 gene promoter:
         HFH-3   AML1a   p53   Nkx2-5   IRF-1   PPAR-alpha   FOXI1   Pax-3   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD38 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD38

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p15.32

CD38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD38 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P015779:  view genomic region     (about GC identifiers)

Start:
 15,779,898 bp from pter      End:
 15,851,069 bp from pter
Size:
 71,172 bases      Orientation:
 plus strand

Proteins
for CD38 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD38_HUMAN, P28907 (See protein sequence)
Recommended Name: ADP-ribosyl cyclase 1  
Size: 300 amino acids; 34328 Da
Subcellular location: Membrane; Single-pass type II membrane protein
Developmental stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also
detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to
decrease during differentiation of blast-forming unit E to colony-forming unit E
6/31 PDB 3D structures from and Proteopedia for CD38 (see all 31):
1YH3 (3D)        1ZVM (3D)        2EF1 (3D)        2HCT (3D)        2I65 (3D)        2I66 (3D)    
Secondary accessions: O00121 O00122 Q96HY4
Alternative splicing: 2 isoforms:  P28907-1   P28907-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CD38: NX_P28907

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P28907

    • CD38 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001766.2  
    ENSEMBL proteins: 
     ENSP00000427277   ENSP00000226279   ENSP00000423047  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: CD38
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    Novus Biologicals CD38 Proteins
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    Sino Biological Recombinant Protein for CD38
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005634nucleus IEA--
    GO:0005792microsome ----
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--


    CD38 for ontologies           About GeneDecksing



    CD38 Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CD38 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CD38 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR003193 ADP-ribosyl_cyclase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P28907

    ProtoNet protein and cluster: P28907

    1 Blocks protein family: IPB003193 ADP-ribosyl cyclase (CD38/157)

    UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
    Similarity: Belongs to the ADP-ribosyl cyclase family


    Function
    for CD38 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
    Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr
    hydrolase activity. Also moonlights as a receptor in cells of the immune system
    Catalytic activity: NAD(+) + H(2)O = ADP-ribose + nicotinamide
    Enzyme regulation: ATP inhibits the hydrolyzing activity

         Genatlas biochemistry entry for CD38:
    cell differentiation antigen CD38 (T10),45kDa,membrane glycoprotein,integral,identified by monoclonal antibody
    OKT10,HB-7,homolog to Aplysia ADRC gene,involved in insulin secretion through mobi-calcium of mobilisation

    Enzyme Number (IUBMB): EC 3.2.2.51

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: CD38 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD38 (see all 7)
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    OriGene siRNA: CD38
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD38

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CD38

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD38 

    Cell Line
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    Search LifeMap BioReagents cell lines for CD38

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD38

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003953NAD+ nucleosidase activity IEA--
    GO:0004872receptor activity ----
    GO:0016798hydrolase activity, acting on glycosyl bonds ----
    GO:0016849phosphorus-oxygen lyase activity IEA--


    CD38 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CD38: Cd38tm1Lnd Cd38tm1Okam
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd38):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  immune system 

    CD38 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CD38 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NAD metabolism
    		NAD metabolism1.00
    		Nicotinate and nicotinamide metabolism0.43
    		NAD metabolism1.00
    2Pancreatic secretion
    		Pancreatic secretion1.00
    3Hematopoietic cell lineage
    		Hematopoietic cell lineage1.00
    4Calcium signaling pathway
    		Calcium signaling pathway1.00
    5Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CD38
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for CD38
        NAD metabolism


    5/6         Kegg Pathways  (Kegg details for CD38) (see all 6):
        Nicotinate and nicotinamide metabolism
    Metabolic pathways
    Calcium signaling pathway
    Hematopoietic cell lineage
    Salivary secretion


    CD38 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD38

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for CD38 (P289073 ENSP000002262794) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCKP062393, ENSP000003378254I2D: score=4 STRING: ENSP00000337825
    CD9P219263, ENSP000000091804I2D: score=2 STRING: ENSP00000009180
    FCGR3AP086373, ENSP000003569464I2D: score=3 STRING: ENSP00000356946
    CD4P017303, ENSP000000116534I2D: score=2 STRING: ENSP00000011653
    PECAM1P162843I2D: score=1 
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0007165signal transduction NAS8253715
    GO:0007204elevation of cytosolic calcium ion concentration IEA--
    GO:0007565female pregnancy IEA--
    GO:0009725response to hormone stimulus ----


    CD38 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CD38 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD38 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CD38

    Browse Tocris compounds for CD38

    8 HMDB Compounds for CD38    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    ADP-ribose 2'-phosphate2'-phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate] (see all 3)26303-90-2--
    Adenosine diphosphate ribose(Rib5)ppA (see all 13)20762-30-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    10/37 Novoseek chemical compound relationships for CD38 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic adp-ribose 94.4 209 8630392 (5), 9020087 (5), 8530408 (4), 9386892 (4) (see all 65)
    nicotinamide guanine dinucleotide 79 3 7982936 (1), 12514117 (1)
    nad+ 78.8 73 9148900 (4), 10477767 (3), 12203397 (3), 7869031 (2) (see all 37)
    naadp 76.5 15 16861223 (4), 8701086 (1), 9193683 (1), 18581239 (1) (see all 6)
    adpribose 69 29 8630392 (3), 9148900 (3), 7869031 (2), 9494110 (2) (see all 15)
    fludarabine 62.6 5 18587576 (1), 14510944 (1), 16284990 (1), 19826055 (1) (see all 5)
    nicotinamide 62.2 10 9148900 (2), 8701086 (1), 7982936 (1), 8258350 (1) (see all 9)
    naad 57 1 15505998 (1)
    nadp+ 50 6 8530456 (2), 8701086 (1), 10369916 (1), 18835239 (1) (see all 5)
    retinoic acid 48.5 55 7511050 (9), 12139742 (5), 9624127 (4), 8663150 (3) (see all 20)

    Search CenterWatch for drugs/clinical trials and news about CD38 

    Transcripts
    for CD38 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CD38 gene: 
    NM_001775.2  

    Unigene Cluster for CD38:

    CD38 molecule
    Hs.479214  [show with all ESTs]
    Unigene Representative Sequence: BF790785
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502843(uc021xmk.1) ENST00000226279(uc003gol.1) ENST00000506191
    ENST00000511430 ENST00000510674

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK297592.1 AK303169.1 AK313268.1 BC007964.2 D84276.1 D84277.1 M34461.1 

    6 DOTS entries:

    DT.440888  DT.95266841  DT.40240101  DT.121251299  DT.86849240  DT.414249 

    24/67 AceView cDNA sequences (see all 67):

    F04175 BP368495 BC007964 F07918 AW059605 BP338873 CR626710 D84277 
    AI989354 BQ056610 BF513368 AA814783 D84276 CR610722 AI052656 CR606718 
    BM909571 BX363630 AA318583 BX098811 CD688069 BX383465 BX401524 AW025725 

    GeneLoc Exon Structure


    Expression
    for CD38 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD38 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CD38 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BloodPeripheral BloodCommon Myeloid Progenitor CellsBlood
    BloodPeripheral BloodErythroid Progenitor CellsBlood
    BloodPeripheral BloodGranulocyte-Monocyte Progenitor CellsBlood
    BloodPeripheral BloodMegakaryocyte-Erythroid Precursor CellsBlood
    BoneBone MarrowHematopoietic Stem CellsBlood
    Lateral Plate MesodermAorta-Gonad-MesonephrosHematopoietic Stem CellsBlood
    LiverLiver BudHematopoietic Stem CellsBlood
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)Bone
    Bone marrow-derived ALDH+ cells (ALD) (Adult Stem / Progenitor Cell)Bone
    Umbilical cord blood stem/progenitor cells (Stemex) (Fetal Stem / Progenitor Cell)Blood, Extraembryonic Tissues
    Endometrial regenerative cell (Adult Stem / Progenitor Cell)Reproductive System
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See CD38 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD38

    SOURCE GeneReport for Unigene cluster: Hs.479214

    UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
    Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant
    lymphoma and neuroblastoma

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD38: 
              Cell Surface Markers in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for CD38 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CD38 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cd381 , 5 CD38 antigen1, 5 72.3(n)1
    59.8(a)1    		   5 (23.85 cM)5
    124941  NM_007646.41  NP_031672.21 
     438688095 
    chicken
    (Gallus gallus)    		 Aves CD381 CD38 molecule 60.53(n)
    47.29(a)    		   422827  NM_001201388.1  NP_001188317.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CR318624.16
    		 --
    		 32(a)
    		 1 → many
    		 24(8806391-8815691)


    ENSEMBL Gene Tree for CD38 (if available)
    TreeFam Gene Tree for CD38 (if available) 

    Paralogs
    for CD38 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD38 gene
    BST12  
    1 SIMAP similar gene for CD38 using alignment to 2 protein entries:     CD38_HUMAN (see all proteins):
    BST1

    CD38 for paralogs           About GeneDecksing



    Genomic Variants
    for CD38 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): CD38
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD38
    DNA2.0 Custom Variant and Variant Library Synthesis for CD38

    Disorders / Diseases
    for CD38 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CD38 for disorders           About GeneDecksing

    OMIM gene information: 107270    OMIM disorders: --

    20/50 diseases for CD38 (see all 50):    About MalaCards
    b-cell non-hodgkin lymphoma    non-hodgkin lymphoma    human immunodeficiency virus infectious disease    prolymphocytic leukemia
    t-cell prolymphocytic leukemia    lichen planus    oral lichen planus    b cell prolymphocytic leukemia
    autism spectrum disorder    severe combined immunodeficiency    familial chronic lymphocytic leukemia    chronic lymphocytic leukemia
    lupus erythematosus    hodgkin's lymphoma    lymphocytic leukemia    burkitt's lymphoma
    b-cell lymphomas    richter's syndrome    acquired immunodeficiency syndrome    lymphoblastic leukemia

    6 diseases from the University of Copenhagen DISEASES database for CD38:
    Leukemia     Multiple myeloma     Lymphoma     Human immunodeficiency virus infectious disease
    Severe combined immunodeficiency     Agammaglobulinemia

    10/35 Novoseek disease relationships for CD38 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphocytic leukemia chronic b-cell 86.6 30 15759031 (2), 16208411 (2), 19240243 (2), 12673718 (2) (see all 20)
    leukemia lymphocytic chronic 85.7 33 12149224 (2), 18424664 (2), 18287138 (2), 16621959 (2) (see all 26)
    leukaemia lymphocytic 67.6 12 16932341 (2), 12181042 (2), 16825496 (1), 18674817 (1) (see all 10)
    leukemia 49.6 11 8663150 (1), 11528102 (1), 17654680 (1), 12139742 (1) (see all 11)
    chromosomal aberrations 44.7 13 18457263 (2), 16529606 (2), 16856923 (1), 20099742 (1) (see all 11)
    myeloma 43.9 5 8187346 (1), 10923440 (1), 1592363 (1), 18626062 (1) (see all 5)
    trisomy 43.8 3 18689273 (1), 12149195 (1), 12688180 (1)
    hiv infections 41 7 9358102 (2), 8671648 (1), 1418775 (1), 8809474 (1) (see all 5)
    myeloid leukemia 34.3 4 7511050 (2), 10048416 (1), 7690555 (1)
    leukemia prolymphocytic 34.2 1 16642047 (1)

    Genetic Association Database (GAD): CD38
    Human Genome Epidemiology (HuGE) Navigator: CD38 (21 documents)

    Export disorders for CD38 gene to outside databases

    Publications
    for CD38 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD38 gene, integrated from 9 sources (see all 457):
    (articles sorted by number of sources associating them with CD38)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. (PubMed id 9074508)1, 2, 3, 9 Nata K.... Okamoto H. (1997)
    2. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. (PubMed id 2319135)1, 2, 3, 9 Jackson D.G. and Bell J.I. (1990)
    3. A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro. (PubMed id 9754820)1, 2, 4, 9 Yagui K.... Kanatsuka A. (1998)
    4. CD38 polymorphisms in Spanish patients with systemic lupus erythematosus. (PubMed id 15219386)1, 4, 9 Gonzalez-Escribano M.F....Nunez-Roldan A. (2004)
    5. CD38 is associated with premenopausal and postmenopausal bone mineral density and postmenopausal bone loss. (PubMed id 16369895)1, 4 Drummond F.J....Molloy M.G. (2006)
    6. Crystal structure of human CD38 extracellular domain. (PubMed id 16154090)1, 2 Liu Q.... Hao Q. (2005)
    7. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Autoimmunity to CD38 and GAD in Type I and Type II diabetes: CD38 and HLA genotypes and clinical phenotypes. (PubMed id 12242463)1, 4 Antonelli A....Ferrannini E. (2002)
    10. Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38. (PubMed id 7961800)1, 2 Tohgo A.... Okamoto H. (1994)

    External Searches for CD38 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CD38 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 952 HGNC: 1667 AceView: CD38 Ensembl:ENSG00000004468 euGenes: HUgn952
    ECgene: CD38 Kegg: 952 H-InvDB: CD38

    Other Databases showing CD38 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CD38 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD38 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD38 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CD38

    Intellectual Property
    for CD38 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CD38 gene:
    Search GeneIP for patents involving CD38

    Licensable Technologies for CD38 gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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