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CD38 Gene

protein-coding   GIFtS: 66
GCID: GC04P015779

CD38 Molecule

(Previous name: CD38 antigen (p45))
  See CD38-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD38 Molecule1 2     T102 3
CD38 Antigen (P45)1 2     CADPr Hydrolase 12 3
ADP-Ribosyl Cyclase 11 2     ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase2
NAD(+) Nucleosidase1 2     EC 3.2.2.53
Cyclic ADP-Ribose Hydrolase 12 3     CD38 Antigen3

External Ids:    HGNC: 16671   Entrez Gene: 9522   Ensembl: ENSG000000044687   OMIM: 1072705   UniProtKB: P289073   

Export aliases for CD38 gene to outside databases

Previous GC identifers: GC04P015595 GC04P015722 GC04P015468 GC04P015530 GC04P015457 GC04P015130


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD38 Gene:
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38
also functions in cell adhesion,signal transduction and calcium signaling. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD38 Gene:
CD38 (CD38 molecule) is a protein-coding gene. Diseases associated with CD38 include chronic lymphocytic leukemia, and plasmablastic lymphoma. GO annotations related to this gene include phosphorus-oxygen lyase activity and NAD+ nucleosidase activity. An important paralog of this gene is BST1.

UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr
hydrolase activity. Also moonlights as a receptor in cells of the immune system

Gene Wiki entry for CD38 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006316.17  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD38 gene promoter:
         HFH-3   AML1a   p53   Nkx2-5   IRF-1   PPAR-alpha   FOXI1   Pax-3   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD38 promoter sequence
   Search Chromatin IP Primers for CD38

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p15.32

CD38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD38 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P015779:  view genomic region     (about GC identifiers)

Start:
15,779,898 bp from pter      End:
15,854,853 bp from pter
Size:
74,956 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CD38_HUMAN, P28907 (See protein sequence)
Recommended Name: ADP-ribosyl cyclase 1  
Size: 300 amino acids; 34328 Da
Developmental stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is
also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was
shown to decrease during differentiation of blast-forming unit E to colony-forming unit E
Selected PDB 3D structures from and Proteopedia for CD38 (see all 33):
1YH3 (3D)        1ZVM (3D)        2EF1 (3D)        2HCT (3D)        2I65 (3D)        2I66 (3D)    
Secondary accessions: O00121 O00122 Q96HY4
Alternative splicing: 2 isoforms:  P28907-1   P28907-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CD38: NX_P28907

Explore proteomics data for CD38 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn100, Asn164, Asn209, Asn219

  • See CD38 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001766.2  
    ENSEMBL proteins: 
     ENSP00000427277   ENSP00000226279   ENSP00000423047  

    CD38 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CD38
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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CD38 (16 products) 

     
    antibodies-online peptides for CD38

    CD38 Antibody Products:

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    antibodies-online antibodies for CD38 (355 products) 

    CD38 Assay Products:

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    Search eBioscience for ELISAs for CD38 
    antibodies-online kits for CD38 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    2 InterPro protein domains:
     IPR003193 ADP-ribosyl_cyclase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P28907

    ProtoNet protein and cluster: P28907

    1 Blocks protein domain: IPB003193 ADP-ribosyl cyclase (CD38/157)

    UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
    Similarity: Belongs to the ADP-ribosyl cyclase family


    Find genes that share domains with CD38           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD38_HUMAN, P28907
    Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr
    hydrolase activity. Also moonlights as a receptor in cells of the immune system
    Catalytic activity: NAD(+) + H(2)O = ADP-D-ribose + nicotinamide
    Enzyme regulation: ATP inhibits the hydrolyzing activity

         Genatlas biochemistry entry for CD38:
    cell differentiation antigen CD38 (T10),45kDa,membrane glycoprotein,integral,identified by monoclonal antibody
    OKT10,HB-7,homolog to Aplysia ADRC gene,involved in insulin secretion through mobi-calcium of mobilisation

         Enzyme Number (IUBMB): EC 3.2.2.51

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003953NAD+ nucleosidase activity IEA--
    GO:0016798hydrolase activity, acting on glycosyl bonds ----
    GO:0016849phosphorus-oxygen lyase activity IEA--
         
    Find genes that share ontologies with CD38           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd38):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with CD38           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD38: Cd38tm1Lnd Cd38tm1Okam

       genOway: Develop your customized and physiologically relevant rodent model for CD38

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    Predesigned siRNA for gene silencing in human, mouse, rat CD38

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD38_HUMAN, P28907: Membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    endoplasmic reticulum2
    extracellular2
    nucleus2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--
    GO:0016020membrane TAS8253715
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CD38           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD38 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Nicotinate and nicotinamide metabolism
    Nicotinate and nicotinamide metabolism0.43
    NAD metabolism0.43
    2Metabolism
    Metabolic pathways0.38
    3Salivary secretion
    Salivary secretion0.34
    4Oxytocin signaling pathway
    Oxytocin signaling pathway0.32
    5Pancreatic secretion
    Pancreatic secretion


    Find genes that share SuperPaths with CD38           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CD38
        NAD metabolism



    Selected Kegg Pathways  (Kegg details for CD38) (see all 8):
        Nicotinate and nicotinamide metabolism
    Metabolic pathways
    Calcium signaling pathway
    Hematopoietic cell lineage
    Oxytocin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD38: 
              Cell Surface Markers in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD38

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD38 (P289073 ENSP000002262794) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCKP062393, ENSP000003378254I2D: score=4 STRING: ENSP00000337825
    CD9P219263, ENSP000000091804I2D: score=2 STRING: ENSP00000009180
    FCGR3AP086373, ENSP000003569464I2D: score=3 STRING: ENSP00000356946
    CD4P017303, ENSP000000116534I2D: score=2 STRING: ENSP00000011653
    PECAM1P162843I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0007165signal transduction NAS8253715
    GO:0007204positive regulation of cytosolic calcium ion concentration IEA--
    GO:0007565female pregnancy IEA--
    GO:0009725response to hormone ----

    Find genes that share ontologies with CD38           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CD38
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD38

    8 HMDB Compounds for CD38    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    ADP-ribose 2'-phosphate2'-phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate] (see all 3)26303-90-2--
    Adenosine diphosphate ribose(Rib5)ppA (see all 13)20762-30-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for CD38 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic adp-ribose 94.4 209 8630392 (5), 9020087 (5), 8530408 (4), 9386892 (4) (see all 65)
    nicotinamide guanine dinucleotide 79 3 7982936 (1), 12514117 (1)
    nad+ 78.8 73 9148900 (4), 10477767 (3), 12203397 (3), 7869031 (2) (see all 37)
    naadp 76.5 15 16861223 (4), 8701086 (1), 9193683 (1), 18581239 (1) (see all 6)
    adpribose 69 29 8630392 (3), 9148900 (3), 7869031 (2), 9494110 (2) (see all 15)
    fludarabine 62.6 5 18587576 (1), 14510944 (1), 16284990 (1), 19826055 (1) (see all 5)
    nicotinamide 62.2 10 9148900 (2), 8701086 (1), 7982936 (1), 8258350 (1) (see all 9)
    naad 57 1 15505998 (1)
    nadp+ 50 6 8530456 (2), 8701086 (1), 10369916 (1), 18835239 (1) (see all 5)
    retinoic acid 48.5 55 7511050 (9), 12139742 (5), 9624127 (4), 8663150 (3) (see all 20)



    Find genes that share compounds with CD38           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD38 gene: 
    NM_001775.2  

    Unigene Cluster for CD38:

    CD38 molecule
    Hs.479214  [show with all ESTs]
    Unigene Representative Sequence: BF790785
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502843(uc021xmk.1) ENST00000226279(uc003gol.1) ENST00000506191
    ENST00000511430 ENST00000510674
    miRNA
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    Additional mRNA sequence: 

    AK297592.1 AK303169.1 AK313268.1 BC007964.2 D84276.1 D84277.1 M34461.1 

    6 DOTS entries:

    DT.440888  DT.95266841  DT.40240101  DT.121251299  DT.86849240  DT.414249 

    Selected AceView cDNA sequences (see all 67):

    CR606718 CR626710 F04175 BQ056610 F07918 AA814783 AI989354 D84276 
    AI052656 BM909571 D84277 BP368495 BF513368 CR610722 AW059605 BP338873 
    BC007964 BX363630 BX101447 AW025725 AV729420 F04340 BX383465 BF941625 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD38 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD38 Expression
    About this image


    CD38 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 23 entries
             Granulocyte-Monocyte Progenitor Cells Hematopoietic Bone Marrow
             Umbilical cord blood stem/progenitor cells (Stemex)
     
     Thymus (Hematopoietic System)    fully expand to see all 7 entries
             Double Negative 1 Thymocytes Thymus
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             S-shaped Body
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
    CD38 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD38 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479214

    UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
    Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant
    lymphoma and neuroblastoma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD38: 
              Cell Surface Markers in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD38 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd381 , 5 CD38 antigen1, 5 72.3(n)1
    59.8(a)1
      5 (23.85 cM)5
    124941  NM_007646.41  NP_031672.21 
     438688095 
    chicken
    (Gallus gallus)
    Aves CD381 CD38 molecule 60.73(n)
    47.77(a)
      422827  NM_001201388.1  NP_001188317.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cd381 CD38 molecule 52.36(n)
    40.89(a)
      496666  NM_001011230.1  NP_001011230.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018868911 ADP-ribosyl cyclase 1-like 48.65(n)
    34.68(a)
      101886891  XM_005162580.1  XP_005162637.1 


    ENSEMBL Gene Tree for CD38 (if available)
    TreeFam Gene Tree for CD38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD38 gene
    BST12  
    1 SIMAP similar gene for CD38 using alignment to 2 protein entries:     CD38_HUMAN (see all proteins):
    BST1

    Find genes that share paralogs with CD38           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD38 (see all 1545)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808296291,2
    --15778379(+) ATACCC/GAAAGG 1 -- us2k10--------
    rs1478398391,2
    --15778464(+) TGGAAC/TCAACC 1 -- us2k10--------
    rs1852362891,2
    --15778535(+) CTGTGC/TAGCCA 1 -- us2k10--------
    rs1922253951,2
    --15778651(+) CACTTA/GTAAGT 1 -- us2k10--------
    rs126514391,2
    C,F,H--15778848(+) gtacaT/Ggtatc 1 -- us2k13Minor allele frequency- G:0.06NA WA 244
    rs1840099691,2
    --15778857(+) TCCCAC/GAACTT 1 -- us2k10--------
    rs737991511,2
    C,F--15779034(+) AGGCCA/GAGAGC 1 -- us2k13Minor allele frequency- G:0.07WA 696
    rs1398098191,2
    --15779105(+) GGGAGC/TTGGGT 1 -- us2k10--------
    rs765328121,2
    C,F--15779140(+) GTCTCT/-GCTTG 1 -- us2k11Minor allele frequency- -:0.06--576
    rs1868638211,2
    --15779175(+) AAGAAA/GAGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD38 (15779898 - 15854853 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD38:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676893CNV Deletion23128226
    nsv10460CNV Loss18304495
    nsv878715CNV Loss21882294
    nsv878714CNV Loss21882294
    nsv527861CNV Gain19592680

    Human Gene Mutation Database (HGMD): CD38
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD38
    DNA2.0 Custom Variant and Variant Library Synthesis for CD38

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107270    OMIM disorders: --

    5 diseases for CD38:    
    About MalaCards
    chronic lymphocytic leukemia    plasmablastic lymphoma    prolymphocytic leukemia    familial chronic lymphocytic leukemia
    b-cell chronic lymphocytic leukemia

    6 diseases from the University of Copenhagen DISEASES database for CD38:
    Leukemia     Multiple myeloma     Human immunodeficiency virus infectious disease     Lymphoma
    Severe combined immunodeficiency     Agammaglobulinemia

    Find genes that share disorders with CD38           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD38 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphocytic leukemia chronic b-cell 86.6 30 15759031 (2), 16208411 (2), 19240243 (2), 12673718 (2) (see all 20)
    leukemia lymphocytic chronic 85.7 33 12149224 (2), 18424664 (2), 18287138 (2), 16621959 (2) (see all 26)
    leukaemia lymphocytic 67.6 12 16932341 (2), 12181042 (2), 16825496 (1), 18674817 (1) (see all 10)
    leukemia 49.6 11 8663150 (1), 11528102 (1), 17654680 (1), 12139742 (1) (see all 11)
    chromosomal aberrations 44.7 13 18457263 (2), 16529606 (2), 16856923 (1), 20099742 (1) (see all 11)
    myeloma 43.9 5 8187346 (1), 10923440 (1), 1592363 (1), 18626062 (1) (see all 5)
    trisomy 43.8 3 18689273 (1), 12149195 (1), 12688180 (1)
    hiv infections 41 7 9358102 (2), 8671648 (1), 1418775 (1), 8809474 (1) (see all 5)
    myeloid leukemia 34.3 4 7511050 (2), 10048416 (1), 7690555 (1)
    leukemia prolymphocytic 34.2 1 16642047 (1)

    Genetic Association Database (GAD): CD38
    Human Genome Epidemiology (HuGE) Navigator: CD38 (21 documents)

    Export disorders for CD38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD38 gene, integrated from 10 sources (see all 470):
    (articles sorted by number of sources associating them with CD38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. (PubMed id 9074508)1, 2, 3, 9 Nata K.... Okamoto H. (Gene 1997)
    2. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. (PubMed id 2319135)1, 2, 3, 9 Jackson D.G. and Bell J.I. (J. Immunol. 1990)
    3. A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro. (PubMed id 9754820)1, 2, 4, 9 Yagui K.... Kanatsuka A. (Diabetologia 1998)
    4. CD38 polymorphisms in Spanish patients with systemic lupus erythematosus. (PubMed id 15219386)1, 4, 9 GonzA!lez-Escribano M.F....NA_A+ez-RoldA!n A. (Hum. Immunol. 2004)
    5. CD38 gene polymorphisms contribute to genetic susceptibility to B-cell chronic lymphocytic leukemia: evidence from two case-control studies in Polish Caucasians. (PubMed id 19240243)1, 4, 9 Jamroziak K....Robak T. (amp 2009)
    6. CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome? (PubMed id 18424664)1, 4, 9 Aydin S....Deaglio S. (Blood 2008)
    7. Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. (PubMed id 20435366)1, 4 Munesue T....Higashida H. (Neurosci. Res. 2010)
    8. CD38 is associated with premenopausal and postmenopausal bone mineral density and postmenopausal bone loss. (PubMed id 16369895)1, 4 Drummond F.J....Molloy M.G. (J. Bone Miner. Metab. 2006)
    9. [Clinical features and CD38 polymorphisms of latent autoimmune diabetes of adults (LADA) in Chengdu]. (PubMed id 16909600)1, 4 Liu L.M....Chen Z.Y. (Sichuan Da Xue Xue Bao Yi Xue Ban 2006)
    10. Crystal structure of human CD38 extracellular domain. (PubMed id 16154090)1, 2 Liu Q.... Hao Q. (Structure 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 952 HGNC: 1667 AceView: CD38 Ensembl:ENSG00000004468 euGenes: HUgn952
    ECgene: CD38 Kegg: 952 H-InvDB: CD38

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD38 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD38 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CD38

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD38 gene:
    Search GeneIP for patents involving CD38

    Licensable Technologies for CD38 gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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