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CD38 Gene

protein-coding GIFtS: 66

GC04P015457

CD38 molecule
(Previous name: CD38 antigen (p45) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.2.2.5 ^³
T10 ^², ³

Descriptions
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase ^²
CD38 antigen ^², ³
CD38 antigen (p45) ^¹, ²
CD38 molecule ^²
Cyclic ADP-ribose hydrolase 1 ^³
cADPr hydrolase 1 ^³
cyclic ADP-ribose hydrolase ^²

External Ids
HGNC: 1667¹
Entrez Gene: 952²
UniProtKB: P28907³
Ensembl: ENSG00000004468⁷

Search outside databases for aliases for CD38 gene

Previous GC identifers: GC04P015595 GC04P015722 GC04P015468 GC04P015530

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CD38:

CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in

leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling.

[provided by RefSeq]

UniProtKB/Swiss-Prot: CD38_HUMAN, P28907

Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion.

Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system

Gene Wiki entry for CD38

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CD38 gene

Entrez Gene cytogenetic band: 4p15 Ensembl cytogenetic band: 4p15.32 HGNC cytogenetic band: 4p15.32

CD38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P015457: (about GC identifiers)

Start:	15,389,029 bp from pter
End:	15,459,806 bp from pter
Size:	70,778 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_006316.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CD38_HUMAN, P28907 (See protein sequence)

Recommended Name: ADP-ribosyl cyclase 1

Size: 300 amino acids; 34328 Da

Subcellular location: Membrane; Single-pass type II membrane protein

Developmental stage: Preferentially expressed at both early and late stages of the B and T-cell

maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the

level of surface expression was shown to decrease during differentiation of blast-forming unit E

to colony-forming unit E

PDB structures from and Proteopedia :

1YH3 (3D)

1ZVM (3D)

2EF1 (3D)

2HCT (3D)

2I65 (3D)

2I66 (3D)

2I67 (3D)

2O3Q (3D)

2O3R (3D)

2O3S (3D)

2O3T (3D)

2O3U (3D)

2PGJ (3D)

2PGL (3D)

3DZF (3D)

3DZG (3D)

3DZH (3D)

3DZI (3D)

3DZJ (3D)

3DZK (3D)

3F6Y (3D)

Secondary accessions: O00121 O00122 Q96HY4

Alternative splicing: 2 isoforms: P28907-1 P28907-2

REFSEQ proteins: NP_001766.2

ENSEMBL proteins:

ENSP00000226279

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for CD38
	R&D Systems Recombinant & Natural Proteins for CD38
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD38, CD38 + CD8)
	Human Recombinant Proteins from Abnova (CD38)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	8253715
GO:0005886	plasma membrane	TAS	8253715
GO:0016021	integral to membrane	IEA	--

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Antibodies for CD38:

	Invitrogen Antibodies for CD38
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CD38
	R&D Systems Antibodies for CD38
	Antibodies from Abcam (CD38, CD38 + CD8), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CD38)
	Novus Biologicals Antibodies for CD38

Assays for CD38:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P28907

ProtoNet protein and cluster: P28907

1 Blocks protein family: IPB003193 ADP-ribosyl cyclase (CD38/157)

UniProtKB/Swiss-Prot: CD38_HUMAN, P28907

Similarity: Belongs to the ADP-ribosyl cyclase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD38)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD38)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001775

Applied Biosystems Silencer® siRNAs for CD38

Sigma-Aldrich siRNA and siRNA Panels for CD38

Sigma-Aldrich shRNA Panels and shRNA for CD38

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001775
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001775
untagged cDNA clone in CMV expression vector: NM_001775

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001775

UniProtKB/Swiss-Prot: CD38_HUMAN, P28907

Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion.

Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system

Catalytic activity: NAD(+) + H(2)O = ADP-ribose + nicotinamide

Enzyme regulation: ATP inhibits the hydrolyzing activity

Enzyme Number (IUBMB): EC 3.2.2.5

Genatlas biochemistry entry for CD38:

cell differentiation antigen CD38 (T10),45kDa,membrane glycoprotein,integral,identified by

monoclonal antibody OKT10,HB-7,homolog to Aplysia ADRC gene,involved in insulin secretion through

mobi-calcium of mobilisation

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd38):

cellular

digestive/alimentary

endocrine/exocrine gland

homeostasis/metabolism

immune system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003953	NAD+ nucleosidase activity	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005488	binding	IEA	--
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	--
GO:0016849	phosphorus-oxygen lyase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for CD38 (Your Favorite Gene powered by Ingenuity)

Nicotinate and Nicotinamide Metabolism

GeneDecks CD38 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CD38

5/109 Interacting proteins for CD38 (ENSP00000226279³) via UniProtKB, MINT, and/or STRING (see all 109 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HLA-C	ENSP00000365412³	STRING (score=.736) STRING (score=.73)
CD4	ENSP00000011653³	STRING (score=.977)
CBL	ENSP00000264033³	STRING (score=.968)
LCK	ENSP00000328213³	STRING (score=.952)
IL2RA	ENSP00000369293³	STRING (score=.947)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	NAS	8253715
GO:0008152	metabolic process	IEA	--
GO:0008624	induction of apoptosis by extracellular signals	TAS	10777496
GO:0030890	positive regulation of B cell proliferation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CD38
10/22 Novoseek chemical compound relationships for CD38 gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclic adp-ribose	94.40	192	8630392 (5), 9020087 (5), 8530408 (4), 9386892 (4) (see all 61)
nicotinamide guanine dinucleotide	79.61	3	7982936 (1), 12514117 (1)
nad+	79.31	72	9148900 (4), 10477767 (3), 12203397 (3), 7869031 (2) (see all 37)
naadp	76.13	12	16861223 (4), 8701086 (1), 9193683 (1), 18581239 (1) (see all 5)
naad	57.89	1	15505998 (1)
nadp+	43.90	6	8530456 (2), 8701086 (1), 10369916 (1), 18835239 (1) (see all 5)
ryanodine	38.28	4	14596927 (3), 15718277 (1)
calcium	30.48	39	12514117 (3), 8530408 (2), 19117080 (2), 18441094 (2) (see all 26)
neopterin	23.78	2	9358102 (1), 9008283 (1)
tgf beta1	14.03	2	17027281 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD38)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD38)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001775

Sigma-Aldrich siRNA and siRNA Panels for CD38

Sigma-Aldrich shRNA Panels and shRNA for CD38

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001775

REFSEQ mRNAs for CD38 gene:

NM_001775.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001775

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001775
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001775
                                 untagged cDNA clone in CMV expression vector: NM_001775

Additional cDNA sequence:

AK297592.1 AK303169.1 AK313268.1 BC007964.2 CR606718.1 CR610722.1 CR626710.1 D84276.1

D84277.1 M34461.1

7 DOTS entries:

DT.440888 DT.95266841 DT.40240101 DT.86849240 DT.121251299 DT.414249 DT.433709

24/67 AceView cDNA sequences (see all 67 ):

BC007964 AI052656 AI989354 BP338873 CR610722 BQ056610 AW059605 F07918

BP368495 F04175 BM909571 D84277 AA814783 CR606718 CR626710 D84276

BF513368 M34461 BX098811 CB957711 BX383465 CD688069 BX363630 BF941625

highest scoring ESTs for CD38:

D84276 AA213567 AA291308 AA318583 AA417096 AA748192 AA765500 AA766375 AA828478 AI052656

Unigene Cluster for CD38:

CD38 molecule

Hs.479214 [show with all ESTs]

Unigene Representative Sequence: BF790785

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000226279

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CD38 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CD38

¹ / ² / ³

3 probe-sets matching CD38 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40323_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D84276	1.00	1.00	1.00	1
205692_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001775	0.60	1.00	0.82	1
205692_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CD38 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.479214
Expression variation in blood from EXPOLDB for CD38
UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary,
placenta, malignant lymphoma and neuroblastoma

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CD38 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CD38¹	--	CD38 molecule	73.87(n) 59.12(a)	403756 NM_001003143.1 NP_001003143.1
chimpanzee (Pan troglodytes)	CD38¹	--	CD38 molecule	99.33(n) 99(a)	745433 XM_001160669.1 XP_001160669.1
rat (Rattus norvegicus)	Cd38¹	--	CD38 molecule	72.75(n) 59.46(a)	25668 NM_013127.1 NP_037259.1
mouse (Mus musculus)	Cd38^{1, 5}	5 (28.00 cM)⁵	CD38 antigen^{1, 5}	72.3(n)¹ 59.8(a)¹	12494¹ NM_007646.3¹ NP_031672.2¹ AA929177⁵ AB016868⁵ (see all 17)
chicken (Gallus gallus)	CD38¹	--	CD38 molecule	60.53(n) 47.65(a)	422827 XM_420774.2 XP_420774.1

About this table Species with no ortholog for CD38

ENSEMBL Gene Tree for CD38

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CD38 gene

BST1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/395 NCBI SNPs in CD38 are shown (see all 395 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 128)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1803404^1,2	C,F,H	15459428(+)	`GGTCCT/GCCACA`	1	--	ut3¹ ese³		5		NA EU EA WA	458
	rs1130169^1,2	C,F,H	15459783(+)	`CAAACC/TATAAA`	1	--	ut3¹		13		EU EA WA NA	1096
	rs6449181^1,2	A,C,H	15388810(+)	`CCCGGT/CTGATG`	1	--	ng5¹		4		EU EA WA	418
	rs1800561^1,2	C,F	15435656(+)	`TCCAGC/TGGGAC`	1	R/W	mis¹		4		EU EA WA	420
	rs16892463^1,2	F,H	15459657(+)	`CCAAAC/GCTCTC`	1	--	ut3¹ ese³		7		NA EU EA WA	562
--	rs12651439^1,2	C	15387946(+)	`gtacaG/Tgtatc`	1	--	ng5¹		0	--	--	--	--
	rs1800051^1,2	C,F,H	15444942(+)	`GAAATA/CAACTA`	1	I/I	syn¹		9		EA NA EU WA	2100
	rs6449195^1,2	A,C,F,H	15423912(+)	`tggacT/Cgtact`	1	--	int¹		11		EU EA WA NA	976
	rs4698121^1,2	A,C,F,H	15427961(+)	`GAGACC/TTGGAG`	1	--	int¹		8		NA EU EA WA	602
	rs7663941^1,2	A,C,F,H	15395422(+)	`CTTCTT/CAATGC`	1	--	int¹		4		EU EA WA	418

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HapMap Linkage Disequilibrium images for CD38 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 107270

10/35 Novoseek disease relationships for CD38 gene (see all 35 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphocytic leukemia chronic b-cell	86.09	30	15759031 (2), 16208411 (2), 19240243 (2), 12673718 (2) (see all 20)
leukemia lymphocytic chronic	83.68	30	12149224 (2), 18424664 (2), 18287138 (2), 16621959 (2) (see all 23)
leukaemia lymphocytic	62.74	10	16932341 (2), 12181042 (2), 16825496 (1), 18674817 (1) (see all 8)
leukemia	49.33	11	8663150 (1), 11528102 (1), 17654680 (1), 12139742 (1) (see all 11)
myeloma	45.60	5	8187346 (1), 10923440 (1), 1592363 (1), 18626062 (1) (see all 5)
chromosomal aberrations	43.59	12	18457263 (2), 16529606 (2), 16856923 (1), 16388316 (1) (see all 10)
trisomy	43.00	3	18689273 (1), 12149195 (1), 12688180 (1)
hiv infections	42.81	7	9358102 (2), 8671648 (1), 1418775 (1), 8809474 (1) (see all 5)
myeloid leukemia	36.05	4	7511050 (2), 10048416 (1), 7690555 (1)
leukemia prolymphocytic	35.77	1	16642047 (1)

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Human Gene Mutation Database: CD38
Genetic Association Database: CD38
Human Genome Epidemiology Navigator: CD38 (15 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/361 PubMed articles for CD38 gene (see all 361 ):

Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. (PubMed id 9074508)^{1, 2, 3, 4} Nata K.... Okamoto H. (1997)
Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. (PubMed id 2319135)^{1, 2, 3, 4} Jackson D.G. and Bell J.I. (1990)
A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro. (PubMed id 9754820)^{1, 3, 4, 6} Yagui K.... Kanatsuka A. (1998)
CD38 polymorphisms in Spanish patients with systemic lupus erythematosus. (PubMed id 15219386)^{1, 3, 6} Gonzalez-Escribano M.F....Nunez-Roldan A. (2004)
CD38 is associated with premenopausal and postmenopausal bone mineral density and postmenopausal bone loss. (PubMed id 16369895)^{3, 6} Drummond F.J....Molloy M.G. (2006)
Crystal structure of human CD38 extracellular domain. (PubMed id 16154090)^{3, 4} Liu Q.... Hao Q. (2005)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Autoimmunity to CD38 and GAD in Type I and Type II diabetes: CD38 and HLA genotypes and clinical phenotypes. (PubMed id 12242463)^{3, 6} Antonelli A....Ferrannini E. (2002)
Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38. (PubMed id 7961800)^{3, 4} Tohgo A.... Okamoto H. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 952	HGNC: 1667	AceView: CD38	Ensembl:ENSG00000004468	euGenes: HUgn952
ECgene: CD38	H-InvDB: CD38

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CD38	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CD38

Licensable Technologies for CD38
(Available from WIS Yeda, Salk, Tufts)

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Licensable Technologies for CD38 gene:

Weizmann Institute:

Enrichment of Repopulating Stem Cells For Clinical Protocols

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CD38:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CD38-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CD38		Antibodies for CD38
	Explore super-pooled esiRNAs		Proteins for CD38
	Lentivirus-delivered shRNAs for CD38		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CD38)
	Antibodies (CD38)
	Chimera RNAi (CD38)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CD38, CD38 + CD8)
	Antibodies (CD38, CD38 + CD8)

Search OriGene for CD38

Search Tocris compounds for CD38

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Antibodies for CD38

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CD38 Gene at Home site.
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CD38 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CD38

Summaries
for CD38

Genomic Location
for CD38

Proteins
for CD38

Protein Domains/
Families
for CD38

Gene Function
for CD38

Pathways & Interactions
for CD38

Drugs & Compounds
for CD38

Transcripts
for CD38

Expression
for CD38

Orthologs
for CD38

Paralogs
for CD38

SNPs/Variants
for CD38

Disorders & Mutations
for CD38

Medical News
for CD38

Publications
for CD38

Search for CD38

Genome Databases showing CD38

Other Databases showing CD38

Specialized Databases showing CD38

Licensable Technologies
for CD38

Services
for CD38

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CD38 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CD38

Summariesfor CD38

Genomic Locationfor CD38

Proteinsfor CD38

Protein Domains/Familiesfor CD38

Gene Functionfor CD38

Pathways & Interactionsfor CD38

Drugs & Compoundsfor CD38

Transcriptsfor CD38

Expression for CD38

Orthologsfor CD38

Paralogsfor CD38

SNPs/Variantsfor CD38

Disorders & Mutationsfor CD38

Medical Newsfor CD38

Publicationsfor CD38

Search for CD38

Genome Databases showing CD38

Other Databases showing CD38

Specialized Databases showing CD38

Licensable Technologiesfor CD38

Servicesfor CD38

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CD38

Summaries
for CD38

Genomic Location
for CD38

Proteins
for CD38

Protein Domains/
Families
for CD38

Gene Function
for CD38

Pathways & Interactions
for CD38

Drugs & Compounds
for CD38

Transcripts
for CD38

Expression
for CD38

Orthologs
for CD38

Paralogs
for CD38

SNPs/Variants
for CD38

Disorders & Mutations
for CD38

Medical News
for CD38

Publications
for CD38

Licensable Technologies
for CD38

Services
for CD38