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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD38 Gene

protein-coding   GIFtS: 66
GCID: GC04P015779

CD38 Molecule

(Previous name: CD38 antigen (p45))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD38 Molecule1 2     T102 3
CD38 Antigen (P45)1 2     CADPr Hydrolase 12 3
ADP-Ribosyl Cyclase 11 2     ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase2
NAD(+) Nucleosidase1 2     EC 3.2.2.53
Cyclic ADP-Ribose Hydrolase 12 3     CD38 Antigen3

External Ids:    HGNC: 16671   Entrez Gene: 9522   Ensembl: ENSG000000044687   OMIM: 1072705   UniProtKB: P289073   

Export aliases for CD38 gene to outside databases

Previous GC identifers: GC04P015595 GC04P015722 GC04P015468 GC04P015530 GC04P015457 GC04P015130


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD38 Gene:
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38
also functions in cell adhesion,signal transduction and calcium signaling. (provided by RefSeq, Jul 2008)

GeneCards Summary for CD38 Gene: 
CD38 (CD38 molecule) is a protein-coding gene. Diseases associated with CD38 include chronic lymphocytic leukemia, and richter's syndrome, and among its related super-pathways are NAD metabolism and Metabolism. GO annotations related to this gene include phosphorus-oxygen lyase activity and nucleotide binding. An important paralog of this gene is BST1.

UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr
hydrolase activity. Also moonlights as a receptor in cells of the immune system

Gene Wiki entry for CD38 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006316.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD38 gene promoter:
         HFH-3   AML1a   p53   Nkx2-5   IRF-1   PPAR-alpha   FOXI1   Pax-3   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD38 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD38

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p15.32

CD38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD38 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P015779:  view genomic region     (about GC identifiers)

Start:
15,779,898 bp from pter      End:
15,851,069 bp from pter
Size:
71,172 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD38_HUMAN, P28907 (See protein sequence)
Recommended Name: ADP-ribosyl cyclase 1  
Size: 300 amino acids; 34328 Da
Subcellular location: Membrane; Single-pass type II membrane protein
Developmental stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is
also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was
shown to decrease during differentiation of blast-forming unit E to colony-forming unit E
6/33 PDB 3D structures from and Proteopedia for CD38 (see all 33):
1YH3 (3D)        1ZVM (3D)        2EF1 (3D)        2HCT (3D)        2I65 (3D)        2I66 (3D)    
Secondary accessions: O00121 O00122 Q96HY4
Alternative splicing: 2 isoforms:  P28907-1   P28907-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CD38: NX_P28907

Explore proteomics data for CD38 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28907

  • CD38 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD38 Protein Expression
    REFSEQ proteins: NP_001766.2  
    ENSEMBL proteins: 
     ENSP00000427277   ENSP00000226279   ENSP00000423047  

    Human Recombinant Protein Products for CD38: 
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    Novus Biologicals CD38 Lysate
    Sino Biological Recombinant Protein for CD38
    Sino Biological Cell Lysate for CD38 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--
    GO:0016020membrane TAS8253715
    GO:0016021integral to membrane IEA--

    CD38 for ontologies           About GeneDecksing



    CD38 Antibody Products: 
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    Assay Products for CD38: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    2 InterPro protein domains:
     IPR003193 ADP-ribosyl_cyclase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P28907

    ProtoNet protein and cluster: P28907

    1 Blocks protein domain: IPB003193 ADP-ribosyl cyclase (CD38/157)

    UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
    Similarity: Belongs to the ADP-ribosyl cyclase family


    CD38 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD38_HUMAN, P28907
    Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr
    hydrolase activity. Also moonlights as a receptor in cells of the immune system
    Catalytic activity: NAD(+) + H(2)O = ADP-ribose + nicotinamide
    Enzyme regulation: ATP inhibits the hydrolyzing activity

         Genatlas biochemistry entry for CD38:
    cell differentiation antigen CD38 (T10),45kDa,membrane glycoprotein,integral,identified by monoclonal antibody
    OKT10,HB-7,homolog to Aplysia ADRC gene,involved in insulin secretion through mobi-calcium of mobilisation

         Enzyme Number (IUBMB): EC 3.2.2.51

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003953NAD+ nucleosidase activity IEA--
    GO:0016798hydrolase activity, acting on glycosyl bonds ----
    GO:0016849phosphorus-oxygen lyase activity IEA--
         
    CD38 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd38):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  immune system 

    CD38 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD38: Cd38tm1Lnd Cd38tm1Okam

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD38 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD38

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD38 
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD38


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD38 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1NAD metabolism
    NAD metabolism0.43
    Nicotinate and nicotinamide metabolism0.43
    2Metabolism
    Metabolic pathways0.40
    3Gastric acid secretion
    Salivary secretion0.34
    4Pancreatic secretion
    Pancreatic secretion
    5Hematopoietic cell lineage
    Hematopoietic cell lineage

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CD38
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for CD38
        NAD metabolism



    5/7         Kegg Pathways  (Kegg details for CD38) (see all 7):
        Nicotinate and nicotinamide metabolism
    Metabolic pathways
    Calcium signaling pathway
    Hematopoietic cell lineage
    Salivary secretion


    CD38 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD38

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for CD38 (P289073 ENSP000002262794) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCKP062393, ENSP000003378254I2D: score=4 STRING: ENSP00000337825
    CD9P219263, ENSP000000091804I2D: score=2 STRING: ENSP00000009180
    FCGR3AP086373, ENSP000003569464I2D: score=3 STRING: ENSP00000356946
    CD4P017303, ENSP000000116534I2D: score=2 STRING: ENSP00000011653
    PECAM1P162843I2D: score=1 
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0007165signal transduction NAS8253715
    GO:0007204elevation of cytosolic calcium ion concentration IEA--
    GO:0007565female pregnancy IEA--
    GO:0009725response to hormone stimulus ----

    CD38 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD38 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CD38

    Browse Tocris compounds for CD38

    8 HMDB Compounds for CD38    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    ADP-ribose 2'-phosphate2'-phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate] (see all 3)26303-90-2--
    Adenosine diphosphate ribose(Rib5)ppA (see all 13)20762-30-5--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/37 Novoseek inferred chemical compound relationships for CD38 gene (see all 37)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic adp-ribose 94.4 209 8630392 (5), 9020087 (5), 8530408 (4), 9386892 (4) (see all 65)
    nicotinamide guanine dinucleotide 79 3 7982936 (1), 12514117 (1)
    nad+ 78.8 73 9148900 (4), 10477767 (3), 12203397 (3), 7869031 (2) (see all 37)
    naadp 76.5 15 16861223 (4), 8701086 (1), 9193683 (1), 18581239 (1) (see all 6)
    adpribose 69 29 8630392 (3), 9148900 (3), 7869031 (2), 9494110 (2) (see all 15)
    fludarabine 62.6 5 18587576 (1), 14510944 (1), 16284990 (1), 19826055 (1) (see all 5)
    nicotinamide 62.2 10 9148900 (2), 8701086 (1), 7982936 (1), 8258350 (1) (see all 9)
    naad 57 1 15505998 (1)
    nadp+ 50 6 8530456 (2), 8701086 (1), 10369916 (1), 18835239 (1) (see all 5)
    retinoic acid 48.5 55 7511050 (9), 12139742 (5), 9624127 (4), 8663150 (3) (see all 20)

    Search CenterWatch for drugs/clinical trials and news about CD38

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD38 gene: 
    NM_001775.2  

    Unigene Cluster for CD38:

    CD38 molecule
    Hs.479214  [show with all ESTs]
    Unigene Representative Sequence: BF790785
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502843(uc021xmk.1) ENST00000226279(uc003gol.1) ENST00000506191
    ENST00000511430 ENST00000510674
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AK297592.1 AK303169.1 AK313268.1 BC007964.2 D84276.1 D84277.1 M34461.1 

    6 DOTS entries:

    DT.440888  DT.95266841  DT.40240101  DT.121251299  DT.86849240  DT.414249 

    24/67 AceView cDNA sequences (see all 67):

    CR606718 D84277 CR610722 BC007964 BQ056610 CR626710 BP338873 AA814783 
    AI052656 BM909571 AW059605 D84276 F07918 BP368495 BF513368 F04175 
    AI989354 CB957711 BX401524 AV729420 M34461 BF679593 BX383465 BX101447 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD38 expression in normal human tissues (normalized intensities)      CD38 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CD38 Expression
    About this image


    CD38 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 23 entries
             Granulocyte-Monocyte Progenitor Cells Hematopoietic Bone Marrow
             Umbilical cord blood stem/progenitor cells (Stemex)
             plasma cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 8 entries
             Double Negative 1 Thymocytes Thymus
             Thymus   
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Medulla Oblongata
             brain/forebrain/telencephalon   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Cardiac progenitor cells
             heart/atrium   
     
     Lymph (Hematopoietic System)    fully expand to see all 3 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   

    See CD38 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD38

    SOURCE GeneReport for Unigene cluster: Hs.479214

    UniProtKB/Swiss-Prot: CD38_HUMAN, P28907
    Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant
    lymphoma and neuroblastoma

        SABiosciences Expression via Pathway-Focused PCR Arrays including CD38: 
              Cell Surface Markers in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD38 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd381 , 5 CD38 antigen1, 5 72.3(n)1
    59.8(a)1
      5 (23.85 cM)5
    124941  NM_007646.41  NP_031672.21 
     438688095 
    chicken
    (Gallus gallus)
    Aves CD381 CD38 molecule 60.53(n)
    47.29(a)
      422827  NM_001201388.1  NP_001188317.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CR318624.16
    Uncharacterized protein
    29(a)
    1 → many
    24(8806391-8815691)


    ENSEMBL Gene Tree for CD38 (if available)
    TreeFam Gene Tree for CD38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD38 gene
    BST12  
    1 SIMAP similar gene for CD38 using alignment to 2 protein entries:     CD38_HUMAN (see all proteins):
    BST1

    CD38 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1545 SNPs in CD38 are shown (see all 1545)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808296291,2
    --15778379(+) ATACCC/GAAAGG 1 -- us2k10--------
    rs1478398391,2
    --15778464(+) TGGAAC/TCAACC 1 -- us2k10--------
    rs1852362891,2
    --15778535(+) CTGTGC/TAGCCA 1 -- us2k10--------
    rs1922253951,2
    --15778651(+) CACTTA/GTAAGT 1 -- us2k10--------
    rs126514391,2
    C,F,H--15778848(+) gtacaT/Ggtatc 1 -- us2k13Minor allele frequency- G:0.06NA WA 244
    rs1840099691,2
    --15778857(+) TCCCAC/GAACTT 1 -- us2k10--------
    rs737991511,2
    C,F--15779034(+) AGGCCA/GAGAGC 1 -- us2k13Minor allele frequency- G:0.07WA 696
    rs1398098191,2
    --15779105(+) GGGAGC/TTGGGT 1 -- us2k10--------
    rs765328121,2
    C,F--15779140(+) GTCTCT/-GCTTG 1 -- us2k11Minor allele frequency- -:0.06--576
    rs1868638211,2
    --15779175(+) AAGAAA/GAGGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD38 (15779898 - 15851069 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CD38:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676893CNV Deletion23128226
    nsv10460CNV Loss18304495
    nsv878715CNV Loss21882294
    nsv878714CNV Loss21882294
    nsv527861CNV Gain19592680


    Human Gene Mutation Database (HGMD): CD38
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD38
    DNA2.0 Custom Variant and Variant Library Synthesis for CD38

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107270    OMIM disorders: --

    20/53 diseases for CD38 (see all 53):    About MalaCards
    chronic lymphocytic leukemia    richter's syndrome    b-cell chronic lymphocytic leukemia    plasmablastic lymphoma
    prolymphocytic leukemia    t-cell prolymphocytic leukemia    familial chronic lymphocytic leukemia    b cell prolymphocytic leukemia
    primary immunodeficiency disease    lymphoblastic lymphoma    acquired immunodeficiency syndrome    human immunodeficiency virus infectious disease
    oral lichen planus    non-hodgkin lymphoma    agammaglobulinemia    hodgkin's lymphoma
    lichen planus    cytomegalovirus infection    burkitt's lymphoma    follicular lymphoma

    6 diseases from the University of Copenhagen DISEASES database for CD38:
    Leukemia     Multiple myeloma     Human immunodeficiency virus infectious disease     Lymphoma
    Severe combined immunodeficiency     Agammaglobulinemia

    CD38 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/35 Novoseek inferred disease relationships for CD38 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphocytic leukemia chronic b-cell 86.6 30 15759031 (2), 16208411 (2), 19240243 (2), 12673718 (2) (see all 20)
    leukemia lymphocytic chronic 85.7 33 12149224 (2), 18424664 (2), 18287138 (2), 16621959 (2) (see all 26)
    leukaemia lymphocytic 67.6 12 16932341 (2), 12181042 (2), 16825496 (1), 18674817 (1) (see all 10)
    leukemia 49.6 11 8663150 (1), 11528102 (1), 17654680 (1), 12139742 (1) (see all 11)
    chromosomal aberrations 44.7 13 18457263 (2), 16529606 (2), 16856923 (1), 20099742 (1) (see all 11)
    myeloma 43.9 5 8187346 (1), 10923440 (1), 1592363 (1), 18626062 (1) (see all 5)
    trisomy 43.8 3 18689273 (1), 12149195 (1), 12688180 (1)
    hiv infections 41 7 9358102 (2), 8671648 (1), 1418775 (1), 8809474 (1) (see all 5)
    myeloid leukemia 34.3 4 7511050 (2), 10048416 (1), 7690555 (1)
    leukemia prolymphocytic 34.2 1 16642047 (1)

    Genetic Association Database (GAD): CD38
    Human Genome Epidemiology (HuGE) Navigator: CD38 (21 documents)

    Export disorders for CD38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD38 gene, integrated from 9 sources (see all 467):
    (articles sorted by number of sources associating them with CD38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. (PubMed id 9074508)1, 2, 3, 9 Nata K.... Okamoto H. (1997)
    2. Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. (PubMed id 2319135)1, 2, 3, 9 Jackson D.G. and Bell J.I. (1990)
    3. A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro. (PubMed id 9754820)1, 2, 4, 9 Yagui K.... Kanatsuka A. (1998)
    4. CD38 polymorphisms in Spanish patients with systemic lupus erythematosus. (PubMed id 15219386)1, 4, 9 Gonzalez-Escribano M.F....Nunez-Roldan A. (2004)
    5. CD38 gene polymorphisms contribute to genetic susceptibility to B-cell chronic lymphocytic leukemia: evidence from two case-control studies in Polish Caucasians. (PubMed id 19240243)1, 4, 9 Jamroziak K....Robak T. (2009)
    6. CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome? (PubMed id 18424664)1, 4, 9 Aydin S....Deaglio S. (2008)
    7. Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. (PubMed id 20435366)1, 4 Munesue T....Higashida H. (2010)
    8. CD38 is associated with premenopausal and postmenopausal bone mineral density and postmenopausal bone loss. (PubMed id 16369895)1, 4 Drummond F.J....Molloy M.G. (2006)
    9. [Clinical features and CD38 polymorphisms of latent autoimmune diabetes of adults (LADA) in Chengdu] (PubMed id 16909600)1, 4 Liu L.M....Chen Z.Y. (2006)
    10. Crystal structure of human CD38 extracellular domain. (PubMed id 16154090)1, 2 Liu Q.... Hao Q. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 952 HGNC: 1667 AceView: CD38 Ensembl:ENSG00000004468 euGenes: HUgn952
    ECgene: CD38 Kegg: 952 H-InvDB: CD38

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD38 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD38 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CD38

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD38 gene:
    Search GeneIP for patents involving CD38

    Licensable Technologies for CD38 gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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