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Aliases for CD37 Gene

Aliases for CD37 Gene

  • CD37 Molecule 2 3
  • Tetraspanin-26 3 4
  • CD37 Antigen 2 4
  • Tspan-26 3 4
  • TSPAN26 3 4
  • Cell Differentiation Antigen 37 3
  • Leukocyte Surface Antigen CD37 3
  • Leukocyte Antigen CD37 3
  • GP52-40 3

External Ids for CD37 Gene

Previous GeneCards Identifiers for CD37 Gene

  • GC19P050496
  • GC19P050206
  • GC19P054514
  • GC19P054531
  • GC19P054532
  • GC19P054533
  • GC19P049838
  • GC19P046215

Summaries for CD37 Gene

Entrez Gene Summary for CD37 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD37 Gene

CD37 (CD37 Molecule) is a Protein Coding gene. Among its related pathways are Hematopoietic cell lineage. An important paralog of this gene is TSPAN9.

Gene Wiki entry for CD37 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD37 Gene

Genomics for CD37 Gene

Regulatory Elements for CD37 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD37 Gene

Start:
49,335,171 bp from pter
End:
49,343,335 bp from pter
Size:
8,165 bases
Orientation:
Plus strand

Genomic View for CD37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD37 Gene

Proteins for CD37 Gene

  • Protein details for CD37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11049-CD37_HUMAN
    Recommended name:
    Leukocyte antigen CD37
    Protein Accession:
    P11049
    Secondary Accessions:
    • B4DVC1
    • Q3KPF9

    Protein attributes for CD37 Gene

    Size:
    281 amino acids
    Molecular mass:
    31703 Da
    Quaternary structure:
    • Interacts with SCIMP.

    Alternative splice isoforms for CD37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD37 Gene

Proteomics data for CD37 Gene at MOPED

Post-translational modifications for CD37 Gene

  • Glycosylation at Asn170, Asn183, and Asn188
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD37 Gene

Domains for CD37 Gene

Gene Families for CD37 Gene

HGNC:
  • CD :CD molecules
  • TSPAN :Tetraspanins

Graphical View of Domain Structure for InterPro Entry

P11049

UniProtKB/Swiss-Prot:

CD37_HUMAN :
  • P11049
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD37: view

Function for CD37 Gene

Molecular function for CD37 Gene

GENATLAS Biochemistry: cell differentiation antigen 37 (gp52-40),52-40kDa,membrane glycoprotein,identified by monoclonal antibodies G28-1,Y29/55,RFB-7,MB-1,M-B371,M-B372

Gene Ontology (GO) - Molecular Function for CD37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21930792
genes like me logo Genes that share ontologies with CD37: view

Phenotypes for CD37 Gene

genes like me logo Genes that share phenotypes with CD37: view

Animal Models for CD37 Gene

MGI Knock Outs for CD37:

Animal Model Products

CRISPR Products

miRNA for CD37 Gene

miRTarBase miRNAs that target CD37

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD37

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD37 Gene

Localization for CD37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD37 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD37 Gene COMPARTMENTS Subcellular localization image for CD37 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CD37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 21930792
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with CD37: view

Pathways for CD37 Gene

SuperPathways for CD37 Gene

Superpath Contained pathways
1 Hematopoietic cell lineage
genes like me logo Genes that share pathways with CD37: view

Pathways by source for CD37 Gene

1 KEGG pathway for CD37 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CD37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0002920 regulation of humoral immune response IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0030886 negative regulation of myeloid dendritic cell activation IEA --
GO:0042832 defense response to protozoan IEA --
genes like me logo Genes that share ontologies with CD37: view

Compounds for CD37 Gene

(1) Novoseek inferred chemical compound relationships for CD37 Gene

Compound -log(P) Hits PubMed IDs
lipid 0 1
genes like me logo Genes that share compounds with CD37: view

Transcripts for CD37 Gene

Unigene Clusters for CD37 Gene

CD37 molecule:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD37

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD37 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1:
SP2: -
SP3:

Relevant External Links for CD37 Gene

GeneLoc Exon Structure for
CD37
ECgene alternative splicing isoforms for
CD37

Expression for CD37 Gene

mRNA expression in normal human tissues for CD37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD37 Gene

This gene is overexpressed in Whole Blood (26.1) and Spleen (5.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD37 Gene

SOURCE GeneReport for Unigene cluster for CD37 Gene Hs.166556

mRNA Expression by UniProt/SwissProt for CD37 Gene

P11049-CD37_HUMAN
Tissue specificity: B-lymphocytes
genes like me logo Genes that share expressions with CD37: view

In Situ Assay Products

Orthologs for CD37 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD37 35
  • 97.75 (n)
  • 95.73 (a)
CD37 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD37 35
  • 84.52 (n)
  • 79.64 (a)
CD37 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD37 35
  • 84.34 (n)
  • 80.43 (a)
CD37 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd37 35
  • 82.68 (n)
  • 80.07 (a)
Cd37 16
Cd37 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD37 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD37 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd37 35
  • 81.02 (n)
  • 79.72 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CD37 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd37 35
  • 54.84 (n)
  • 47.92 (a)
zebrafish
(Danio rerio)
Actinopterygii CD37 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tsp66E 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-11 36
  • 18 (a)
ManyToMany
tsp-13 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
Species with no ortholog for CD37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD37 Gene

ENSEMBL:
Gene Tree for CD37 (if available)
TreeFam:
Gene Tree for CD37 (if available)

Paralogs for CD37 Gene

Paralogs for CD37 Gene

Selected SIMAP similar genes for CD37 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CD37: view

Variants for CD37 Gene

Sequence variations from dbSNP and Humsavar for CD37 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs164820 -- 49,339,567(+) AGGGT(A/G)GGGGC intron-variant
rs354020 -- 49,335,634(-) CCCCG(G/T)CTGGG intron-variant
rs354021 -- 49,335,758(-) TTGTC(A/G/T)ATGAG utr-variant-5-prime, synonymous-codon, reference
rs354022 -- 49,336,026(-) ACCAG(C/T)CACAA intron-variant
rs354023 -- 49,336,171(-) TCATT(A/G)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD37 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv52n68 CNV Loss 17160897
nsv912261 CNV Loss 21882294

Relevant External Links for CD37 Gene

HapMap Linkage Disequilibrium report
CD37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD37 Gene

Disorders for CD37 Gene

(2) University of Copenhagen DISEASES for CD37 Gene

(1) Novoseek inferred disease relationships for CD37 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for CD37

Genetic Association Database (GAD)
CD37
Human Genome Epidemiology (HuGE) Navigator
CD37
genes like me logo Genes that share disorders with CD37: view

No data available for UniProtKB/Swiss-Prot for CD37 Gene

Publications for CD37 Gene

  1. The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. (PMID: 2388030) Classon B.J. … Stamenkovic I. (J. Exp. Med. 1990) 3 4 23
  2. Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract. (PMID: 10405235) Okochi H. … Furue M. (J. Clin. Gastroenterol. 1999) 3 23
  3. Functional expression of transmembrane 4 superfamily molecules on human eosinophils. (PMID: 10529602) Matsumoto K. … Kurashige T. (Int. Arch. Allergy Immunol. 1999) 3 23
  4. The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes. (PMID: 8436422) Virtaneva K.I. … SchrAPder J. (Immunogenetics 1993) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CD37 Gene

Sources for CD37 Gene

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