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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD37 Gene

protein-coding   GIFtS: 60
GCID: GC19P049838

CD37 Molecule

(Previous name: CD37 antigen)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD37 Molecule1 2     Leukocyte Surface Antigen CD372
CD37 Antigen1 2 3     tetraspanin-262
TSPAN262 3     tspan-262
GP52-402     Tetraspanin-263
Cell Differentiation Antigen 372     Tspan-263
Leukocyte Antigen CD372     

External Ids:    HGNC: 16661   Entrez Gene: 9512   Ensembl: ENSG000001048947   OMIM: 1515235   UniProtKB: P110493   

Export aliases for CD37 gene to outside databases

Previous GC identifers: GC19P050496 GC19P050206 GC19P054514 GC19P054531 GC19P054532 GC19P054533 GC19P046215


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD37 Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known
to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell
interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CD37 Gene: 
CD37 (CD37 molecule) is a protein-coding gene. Diseases associated with CD37 include merkel cell carcinoma, and oral squamous cell carcinoma. GO annotations related to this gene include protein binding. An important paralog of this gene is CD151.

Gene Wiki entry for CD37 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD37 gene promoter:
         RP58   USF1   GCNF   Lmo2   USF2   USF-1:USF-2   HEN1   USF-1   HFH-1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD37 promoter sequence
   Search SABiosciences Chromatin IP Primers for CD37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19p13-q13.4

CD37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD37 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049838:  view genomic region     (about GC identifiers)

Start:
49,838,428 bp from pter      End:
49,846,592 bp from pter
Size:
8,165 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD37_HUMAN, P11049 (See protein sequence)
Recommended Name: Leukocyte antigen CD37  
Size: 281 amino acids; 31703 Da
Subunit: Interacts with SCIMP
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B4DVC1 Q3KPF9
Alternative splicing: 3 isoforms:  P11049-1   P11049-2   P11049-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD37: NX_P11049

Explore proteomics data for CD37 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11049

  • CD37 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD37 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001035120.1  NP_001765.1  

    ENSEMBL proteins: 
     ENSP00000375732   ENSP00000470394   ENSP00000413151   ENSP00000471902   ENSP00000325708  
     ENSP00000441037   ENSP00000471078   ENSP00000470260   ENSP00000470683  

    Human Recombinant Protein Products for CD37: 
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    OriGene Protein Over-expression Lysate for CD37
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CD37
    GenScript Custom Purified and Recombinant Proteins Services for CD37
    Novus Biologicals CD37 Protein
    Novus Biologicals CD37 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IDA--
    GO:0016021integral to membrane IEA--

    CD37 for ontologies           About GeneDecksing



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    Assay Products for CD37: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P11049

    ProtoNet protein and cluster: P11049

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: CD37_HUMAN, P11049
    Similarity: Belongs to the tetraspanin (TM4SF) family


    CD37 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for CD37:
    cell differentiation antigen 37 (gp52-40),52-40kDa,membrane glycoprotein,identified by monoclonal antibodies
    G28-1,Y29/55,RFB-7,MB-1,M-B371,M-B372

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CD37 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cd37):
     cellular  hematopoietic system  immune system 

    CD37 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cd37tm1Hor for CD37

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD37 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD37

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD37 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD37 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD37
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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for CD37
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                         Customized lentivirus expression plasmids for stable overexpression of CD37 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD37


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CD37 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hematopoietic cell lineage
    Hematopoietic cell lineage

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for CD37):
        Hematopoietic cell lineage


    CD37 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CD37

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for CD37 (P110491, 3 ENSP000003257084) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293501, ENSP000003915924EBI-6139068,EBI-78260 STRING: ENSP00000391592
    SYKP434051, ENSP000003648984EBI-6139068,EBI-78302 STRING: ENSP00000364898
    CLEC7AQ9BXN23I2D: score=1 
    LYNP079481EBI-6139068,EBI-79452
    PIK3CDENSP000003665634STRING: ENSP00000366563
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002639positive regulation of immunoglobulin production IEA--
    GO:0002920regulation of humoral immune response IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0030886negative regulation of myeloid dendritic cell activation IEA--
    GO:0042832defense response to protozoan IEA--

    CD37 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CD37 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD37

    1 Novoseek inferred chemical compound relationship for CD37 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 0 1 8845018 (1)

    Search CenterWatch for drugs/clinical trials and news about CD37

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD37 gene (2 alternative transcripts): 
    NM_001040031.1  NM_001774.2  

    Unigene Cluster for CD37:

    CD37 molecule
    Hs.166556  [show with all ESTs]
    Unigene Representative Sequence: AL833693
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391859(uc002pnc.3) ENST00000597033 ENST00000598095 ENST00000426897(uc002pne.3)
    ENST00000595725 ENST00000323906(uc002pnd.3) ENST00000593512 ENST00000597852
    ENST00000535669(uc010yam.1 uc010yan.1 uc002pnf.3) ENST00000596426
    ENST00000598134 ENST00000597602 ENST00000595660 ENST00000594743 ENST00000600121

    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CD37
    SwitchGear 3'UTR luciferase reporter plasmidCD37 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CD37
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD37
    Clone
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    OriGene ORF clones in mouse, rat for CD37
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD37 (NM_001774)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD37
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD37
    Sirion Biotech Customized lentivirus for stable overexpression of CD37 
                         Customized lentivirus expression plasmids for stable overexpression of CD37 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CD37
    OriGene qSTAR qPCR primer pairs in human, mouse for CD37
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD37
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD37
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD37

    Additional mRNA sequence: 

    AK058093.1 AK301016.1 AK301328.1 AK316348.1 AL833693.1 BC106752.1 BC110379.1 BT019851.1 
    CR541877.1 X14046.1 

    16 DOTS entries:

    DT.313089  DT.121427283  DT.92438848  DT.86835852  DT.100783528  DT.121427256  DT.121643586  DT.121427269 
    DT.95363980  DT.100800018  DT.121427294  DT.92438852  DT.100027135  DT.95085967  DT.95280177  DT.97795381 

    11 AceView cDNA sequences:

    CR612129 CR618735 X14046 CR616413 NM_001774 CR594834 CR598140 CR615545 
    CR541877 AL833693 AK058093 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CD37    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
    SP1:                                                                        
    SP2:        -                                                               
    SP3:                                                                        


    ECgene alternative splicing isoforms for CD37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD37 expression in normal human tissues (normalized intensities)      CD37 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGCTCTCGA
    CD37 Expression
    About this image


    CD37 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 15 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             Peripheral blood Pan-T Cells   
             BONE MARROW   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Cord Blood Pan-T Cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 3 entries
             lymph node ; germinal center cells   
             Lymphnode   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Fetal Liver CD36+ Cells   

    See CD37 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD37

    SOURCE GeneReport for Unigene cluster: Hs.166556

    UniProtKB/Swiss-Prot: CD37_HUMAN, P11049
    Tissue specificity: B-lymphocytes

        SABiosciences Expression via Pathway-Focused PCR Array including CD37: 
              Cell Surface Markers in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CD37 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd371 , 5 CD37 antigen1, 5 82.68(n)1
    80.07(a)1
      7 (29.20 cM)5
    124931  NM_007645.41  NP_031671.11 
     452336325 
    lizard
    (Anolis carolinensis)
    Reptilia CD376
    Uncharacterized protein
    42(a)
    1 ↔ 1
    GL343355.1(68638-89200)
    zebrafish
    (Danio rerio)
    Actinopterygii CD376
    CD37 molecule
    35(a)
    1 ↔ 1
    12(30519497-30531745)
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp66E6
    Tetraspanin 66E
    24(a)
    1 → many
    3L(8905599-8925165)


    ENSEMBL Gene Tree for CD37 (if available)
    TreeFam Gene Tree for CD37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD37 gene
    CD1512  TSPAN12  TSPAN62  TSPAN32  TSPAN92  CD632  TSPAN192  CD532  
    CD822  TSPAN182  TSPAN72  TSPAN112  TSPAN42  ENSG000002503492  
    8 SIMAP similar genes for CD37 using alignment to 7 protein entries:     CD37_HUMAN (see all proteins):
    CD82    CD53    TSPAN4    CD9    TSPAN18    TSPAN9
    BTCC-1    TSPAN2

    CD37 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/168 SNPs in CD37 are shown (see all 168)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824823711,2
    --49836710(+) GCGAAA/GAGTGA 2 -- us2k10--------
    rs1494100361,2
    --49836759(+) GGGATA/GAGGCA 2 -- us2k10--------
    rs784273931,2
    F--49837185(+) CCAGGC/TTCAGT 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1877038581,2
    --49837243(+) GGAAGC/TACCGC 2 -- us2k10--------
    rs14656971,2
    C,F,A--49837246(-) CAGGCG/AGTACT 2 -- us2k1 tfbs314Minor allele frequency- A:0.32EA NA WA CSA 589
    rs1427912481,2
    C--49837289(+) CCCAG-/CGC   
      CCTCCC
    CACTC
    2 -- us2k10--------
    rs14656961,2
    C,F,A,H--49837439(-) TGTCTC/TCCCCT 2 -- us2k1 trp317Minor allele frequency- T:0.13NA EA MN NS 1920
    rs1439154301,2
    --49837479(+) CTCACG/TCCCAT 2 -- us2k10--------
    rs1910728321,2
    --49837495(+) CAGCAC/GTTTAG 2 -- us2k10--------
    rs1486409051,2
    --49837565(+) GTGAGA/GCTCCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD37 (49838428 - 49846592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CD37:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv52n68CNV Loss17160897
    nsv912261CNV Loss21882294
    nsv9739CNV Gain+Loss18304495

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD37
    DNA2.0 Custom Variant and Variant Library Synthesis for CD37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 151523    OMIM disorders: --

    5 diseases for CD37:    About MalaCards
    merkel cell carcinoma    oral squamous cell carcinoma    chronic lymphocytic leukemia    squamous cell carcinoma
    leukemia

    2 diseases from the University of Copenhagen DISEASES database for CD37:
    Lymphoma     Chronic lymphocytic leukemia

    CD37 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CD37 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 15931266 (1), 20118909 (1)

    Genetic Association Database (GAD): CD37
    Human Genome Epidemiology (HuGE) Navigator: CD37 (4 documents)

    Export disorders for CD37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD37 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with CD37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. (PubMed id 2388030)1, 2, 9 Classon B.J....Stamenkovic I. (1990)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes. (PubMed id 8436422)1, 3 Virtaneva K.I....Schroder J. (1993)
    5. The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. (PubMed id 2466944)1, 2 Classon B.J.... Stamenkovic I. (1989)
    6. Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract. (PubMed id 10405235)1, 9 Okochi H....Furue M. (1999)
    7. Functional expression of transmembrane 4 superfamily molecules on human eosinophils. (PubMed id 10529602)1, 9 Matsumoto K....Kurashige T. (1999)
    8. Tetraspanin CD37 directly mediates transduction of sur vival and apoptotic signals. (PubMed id 22624718)1 Lapalombella R....Byrd J.C. (2012)
    9. SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling. (PubMed id 21930792)2 Draber P....Brdicka T. (2011)
    10. A complementary role for the tetraspanins CD37 and Ts sc6 in cellular immunity. (PubMed id 20709950)1 Gartlan K.H....Wright M.D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 951 HGNC: 1666 AceView: CD37 Ensembl:ENSG00000104894 euGenes: HUgn951
    ECgene: CD37 Kegg: 951 H-InvDB: CD37

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD37 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD37 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD37 gene:
    Search GeneIP for patents involving CD37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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