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CD36 Gene(Protein Coding)

CD36 Molecule

GCID:
GC07P080369
GIFtS:
70
Genes Participants
UDN Logo

Aliases for CD36 Gene

Aliases for CD36 Gene

  • CD36 Molecule 2 3 5
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor) 2 3
  • CD36 Molecule (Thrombospondin Receptor) 2 3
  • Leukocyte Differentiation Antigen CD36 3 4
  • Platelet Glycoprotein IV 3 4
  • Fatty Acid Translocase 3 4
  • Glycoprotein IIIb 3 4
  • PAS IV 3 4
  • GPIIIB 3 4
  • GP3B 3 4
  • GPIV 3 4
  • FAT 3 4
  • GP4 3 4
  • Scavenger Receptor Class B, Member 3 3
  • Platelet Collagen Receptor 4
  • Platelet Glycoprotein 4 3
  • Thrombospondin Receptor 4
  • Cluster Determinant 36 3
  • PAS-4 Protein 3
  • CD36 Antigen 4
  • BDPLT10 3
  • SCARB3 3
  • CHDS7 3
  • PASIV 3
  • PAS-4 4

External Ids for CD36 Gene

Previous GeneCards Identifiers for CD36 Gene

  • GC07P078803
  • GC07P078534
  • GC07P079829
  • GC07P079880
  • GC07P079887
  • GC07P079876
  • GC07P080069
  • GC07P074834

Summaries for CD36 Gene

Entrez Gene Summary for CD36 Gene

  • The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CD36 Gene

CD36 (CD36 Molecule) is a Protein Coding gene. Diseases associated with CD36 include Platelet Glycoprotein Iv Deficiency and Coronary Heart Disease 7. Among its related pathways are LDL Oxidation in Atherogenesis and Activated TLR4 signalling. GO annotations related to this gene include lipid binding and low-density lipoprotein particle binding. An important paralog of this gene is SCARB2.

UniProtKB/Swiss-Prot for CD36 Gene

  • Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellulare calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).

  • (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.

Gene Wiki entry for CD36 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD36 Gene

Genomics for CD36 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CD36 Gene

Enhancers for CD36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G080720 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +353.7 353725 5.0 PKNOX1 ARNT SIN3A FEZF1 BRCA1 ZNF2 FOS DEK SP3 TSHZ1 CD36 GC07P080720 GC07P080753
GH07G080640 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +273.0 273027 3.6 ELF3 PKNOX1 FOXA2 RAD21 FOS CREM MIXL1 JUNB CEBPB KAT8 CD36 GC07P080641 ENSG00000229436
GH07G080310 0.9 Ensembl ENCODE 11.6 -57.3 -57291 3.1 ELF3 FOXA2 ZNF680 FOXA3 JUN BHLHE40 RFX3 GATA2 SCRT2 ZNF600 CD36 GNAI1 ENSG00000234223 RN7SL869P
GH07G080711 0.9 Ensembl ENCODE dbSUPER 11.2 +342.1 342065 0.9 ZBTB40 CD36 SEMA3C GC07P080719 ENSG00000229436
GH07G080182 0.8 ENCODE dbSUPER 11 -186.4 -186364 1.9 JUND HDAC2 TEAD4 POU5F1 CHD7 CD36 GC07P080156 GC07P080218 GC07P080219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD36 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CD36 gene promoter:

Genomic Location for CD36 Gene

Chromosome:
7
Start:
80,369,575 bp from pter
End:
80,679,277 bp from pter
Size:
309,703 bases
Orientation:
Plus strand

Genomic View for CD36 Gene

Genes around CD36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD36 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD36 Gene

Proteins for CD36 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CD36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16671-CD36_HUMAN
    Recommended name:
    Platelet glycoprotein 4
    Protein Accession:
    P16671
    Secondary Accessions:
    • D9IX66
    • D9IX67
    • D9IX68
    • D9IX69
    • Q13966
    • Q16093
    • Q8TCV7
    • Q9BPZ8
    • Q9BQC2
    • Q9BZM8
    • Q9BZN3
    • Q9BZN4
    • Q9BZN5

    Protein attributes for CD36 Gene

    Size:
    472 amino acids
    Molecular mass:
    53053 Da
    Quaternary structure:
    • Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (PubMed:1371676). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4:TLR6 heterodimerization and signal initiation (PubMed:1371676, PubMed:20037584). Upon interaction with ligands such as diacylated lipopeptides, interacts with the TLR2:TLR6 heterodimer (PubMed:16880211). Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (By similarity).
    • (Microbial infection) Binds to Plasmodium falciparum EMP1.
    SequenceCaution:
    • Sequence=AAM14636.2; Type=Frameshift; Positions=53; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD36 Gene

    Alternative splice isoforms for CD36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD36 Gene

Protein Expression for CD36 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CD36 Gene

  • N-glycosylated and O-glycosylated with a ratio of 2:1.
  • Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783).
  • Glycosylation at posLast=7979, Asn102, Asn134, posLast=163163, posLast=205205, Asn220, posLast=235235, posLast=247247, posLast=321321, and posLast=417417
  • Modification sites at PhosphoSitePlus

Other Protein References for CD36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD36 Gene

Domains & Families for CD36 Gene

Gene Families for CD36 Gene

HGNC:

Protein Domains for CD36 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16671

UniProtKB/Swiss-Prot:

CD36_HUMAN :
  • Belongs to the CD36 family.
Family:
  • Belongs to the CD36 family.
genes like me logo Genes that share domains with CD36: view

Function for CD36 Gene

Products:

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line
  7. Flow Cytometry

Molecular function for CD36 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD36 (platelet GPIV),85kDa,adhesive cell surface,single glycoprotein,identified by monoclonal antibodies TP85,SMO,ESIVC7,5F1,CD38,expressed in various epithelial and endothelial cells and in erythrocytes
UniProtKB/Swiss-Prot Function:
Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellulare calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.

Gene Ontology (GO) - Molecular Function for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity TAS 9568716
GO:0005515 protein binding IPI 16880211
GO:0008035 high-density lipoprotein particle binding IEA --
GO:0008289 lipid binding IDA 10772654
GO:0030169 low-density lipoprotein particle binding IDA 10772654
genes like me logo Genes that share ontologies with CD36: view
genes like me logo Genes that share phenotypes with CD36: view

Human Phenotype Ontology for CD36 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD36 Gene

MGI Knock Outs for CD36:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD36

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD36 Gene

Localization for CD36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD36 Gene

Cell membrane; Multi-pass membrane protein. Membrane raft. Golgi apparatus. Apical cell membrane. Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis. {ECO:0000269 PubMed:20037584}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD36 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
mitochondrion 2
peroxisome 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005794 Golgi apparatus IEA,IDA 16880211
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9568716
genes like me logo Genes that share ontologies with CD36: view

Pathways & Interactions for CD36 Gene

genes like me logo Genes that share pathways with CD36: view

Gene Ontology (GO) - Biological Process for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001954 positive regulation of cell-matrix adhesion IDA 17416590
GO:0002221 pattern recognition receptor signaling pathway IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with CD36: view

No data available for SIGNOR curated interactions for CD36 Gene

Drugs & Compounds for CD36 Gene

Products:

  1. Drug

(78) Drugs for CD36 Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ABT-510 Investigational Pharma 0
Anticholesteremic Agents Pharma 2025
Anticoagulants Pharma 2623
Antimetabolites Pharma 12054
Atorvastatin Calcium Pharma HMG-CoA reductase inhibitor 760

(59) Additional Compounds for CD36 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Triglycerides Group B
  • 1-Myristoyl-2-myristoyl-3-pentadecanoyl-glycerol
  • 1-Tetradecanoyl-2-tetradecanoyl-3-pentadecanoyl-glycerol
  • TAG(14:0/14:0/15:0)
  • TAG(43:0)
  • TG(43:0)
 555-45-3, 30719-27-8, 2190-24-1, 18641-57-1, 56933-26-7
Triglycerides Group C
  • 1-Stearoyl-2-stearoyl-3-stearoyl-glycerol
  • TAG(18:0/18:0/18:0)
  • TAG(54:0)
  • TG(18:0/18:0/18:0)
  • TG(54:0)
genes like me logo Genes that share compounds with CD36: view

Transcripts for CD36 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CD36 Gene

(11) REFSEQ mRNAs :
(20) Additional mRNA sequences :
(391) Selected AceView cDNA sequences:
(23) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD36 Gene

CD36 molecule (thrombospondin receptor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD36 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ·
SP1: - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - -
SP13: -
SP14:
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - - - -
SP19: -
SP20:

ExUns: 14e · 14f ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25
SP1: - - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:

Relevant External Links for CD36 Gene

GeneLoc Exon Structure for
CD36
ECgene alternative splicing isoforms for
CD36

Expression for CD36 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD36 Gene

mRNA expression in normal human tissues for CD36 Gene
mRNA expression by BioGPS for CD36 GenemRNA expression by GTEx for CD36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD36 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x11.0), Adipose - Subcutaneous (x9.6), Heart - Left Ventricle (x8.8), and Breast - Mammary Tissue (x6.2).

Protein differential expression in normal tissues from HIPED for CD36 Gene

This gene is overexpressed in Adipocyte (24.5), Nasopharynx (20.6), and Milk (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD36 Gene



NURSA nuclear receptor signaling pathways regulating expression of CD36 Gene:

CD36

SOURCE GeneReport for Unigene cluster for CD36 Gene:

Hs.120949

Evidence on tissue expression from TISSUES for CD36 Gene

  • Heart(4.8)
  • Blood(4.7)
  • Muscle(4.7)
  • Liver(4.6)
  • Spleen(3.8)
  • Intestine(2.5)
  • Bone marrow(2.2)
  • Lung(2.1)
  • Gall bladder(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD36 Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • endocrine
Organs:
General:
  • blood
  • blood vessel
  • coagulation system
genes like me logo Genes that share expression patterns with CD36: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CD36 Gene

Orthologs for CD36 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CD36 34 35
  • 99.65 (n)
cow
(Bos Taurus)
 Mammalia CD36 34 35
  • 86.98 (n)
-- 35
  • 73 (a)
 OneToMany
-- 35
  • 67 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia CD36 34 35
  • 86.35 (n)
mouse
(Mus musculus)
 Mammalia Cd36 34 16 35
  • 83.83 (n)
rat
(Rattus norvegicus)
 Mammalia Cd36 34
  • 83.33 (n)
oppossum
(Monodelphis domestica)
 Mammalia CD36 35
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CD36 35
  • 73 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CD36 34 35
  • 65.53 (n)
lizard
(Anolis carolinensis)
 Reptilia CD36 35
  • 61 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cd36 34
  • 63.08 (n)
zebrafish
(Danio rerio)
 Actinopterygii cd36 34 35
  • 60.07 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG3829 36
  • 27 (a)
BEST:CK01577 36
  • 26 (a)
CG7227 36
  • 26 (a)
Snmp2 35
  • 24 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea scav-2 34 35
  • 45.03 (n)
Y76A2B.6 36
  • 28 (a)
C03F11.3 36
  • 24 (a)
scav-1 35
  • 24 (a)
 ManyToMany
Species where no ortholog for CD36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD36 Gene

ENSEMBL:
Gene Tree for CD36 (if available)
TreeFam:
Gene Tree for CD36 (if available)

Paralogs for CD36 Gene

Variants for CD36 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD36 Gene

CD36_HUMAN-P16671
Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIM:611162].

Sequence variations from dbSNP and Humsavar for CD36 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs121918035 Pathogenic, Platelet glycoprotein IV deficiency (PG4D) [MIM:608404] 80,673,392(+) TGCCT(A/C)TTCTT nc-transcript-variant, reference, missense
rs142186404 Pathogenic, Platelet glycoprotein IV deficiency (PG4D) [MIM:608404] 80,669,964(+) CCTCA(C/G/T)TTCCA intron-variant, nc-transcript-variant, reference, missense
rs3765187 Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]
rs75326924 Pathogenic 80,656,687(+) GAGGT(C/T)CTTAT nc-transcript-variant, reference, missense
rs886043043 Pathogenic 80,672,799(+) GCAAA(-/A)CGGCT nc-transcript-variant, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for CD36 Gene

Variant ID Type Subtype PubMed ID
dgv6514n100 CNV loss 25217958
dgv6515n100 CNV loss 25217958
esv2761341 CNV loss 21179565
esv3571939 CNV loss 25503493
esv3613863 CNV loss 21293372
esv3613865 CNV loss 21293372
esv3891151 CNV loss 25118596
nsv1025144 CNV gain 25217958
nsv464606 CNV gain 19166990
nsv464607 CNV loss 19166990
nsv525704 CNV loss 19592680
nsv607682 CNV gain 21841781
nsv607683 CNV loss 21841781
nsv607684 CNV loss 21841781
nsv607685 CNV loss 21841781
nsv831043 CNV loss 17160897
nsv971195 CNV deletion 23825009

Variation tolerance for CD36 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD36 Gene

Human Gene Mutation Database (HGMD)
CD36
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD36

Disorders for CD36 Gene

MalaCards: The human disease database

(55) MalaCards diseases for CD36 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
platelet glycoprotein iv deficiency
  • platelet-type bleeding disorder 10
coronary heart disease 7
  • chds7
malaria
  • malaria, severe
primary optic atrophy
eosinophilic granuloma
  • chronic and localized langerhans cell histiocytosis
- elite association - COSMIC cancer census association via MalaCards
Search CD36 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD36_HUMAN
  • Coronary heart disease 7 (CHDS7) [MIM:610938]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269 PubMed:15282206}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. {ECO:0000269 PubMed:11950861, ECO:0000269 PubMed:7533783}. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients also have postprandial hypertriglyceridemia, insulin resistance and hypertension increasing atherosclerotic risk. {ECO:0000269 PubMed:18753675}.

Genatlas disease for CD36 Gene

platelet CD36 deficiency,type I,with no expression at cell surface

Relevant External Links for CD36

Genetic Association Database (GAD)
CD36
Human Genome Epidemiology (HuGE) Navigator
CD36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD36
genes like me logo Genes that share disorders with CD36: view

Publications for CD36 Gene

  1. CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria. (PMID: 19864601) Erdman L.K. … Kain K.C. (J. Immunol. 2009) 3 4 22 64
  2. A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. (PMID: 15282206) Ma X. … Doria A. (Hum. Mol. Genet. 2004) 3 4 46 64
  3. CD36 polymorphism is associated with protection from cerebral malaria. (PMID: 12506336) Omi K. … Tokunaga K. (Am. J. Hum. Genet. 2003) 3 4 46 64
  4. Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. (PMID: 7503937) Fernandez-Ruiz E. … Vega M.A. (Genomics 1993) 2 3 4 64
  5. The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women. (PMID: 25822988) Mrizak I. … Khan N.A. (Br. J. Nutr. 2015) 3 4 64

Products for CD36 Gene

  • Cloud-Clone Corp. Antibodies for CD36
  • Cloud-Clone Corp. Proteins for CD36
  • Cloud-Clone Corp Assay Kits for CD36
  • Addgene plasmids for CD36

Sources for CD36 Gene

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