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Aliases for CD36 Gene

Aliases for CD36 Gene

  • CD36 Molecule 2 3 5
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor) 2 3
  • CD36 Molecule (Thrombospondin Receptor) 2 3
  • Leukocyte Differentiation Antigen CD36 3 4
  • Platelet Glycoprotein IV 3 4
  • Fatty Acid Translocase 3 4
  • Glycoprotein IIIb 3 4
  • PAS IV 3 4
  • GPIIIB 3 4
  • GP3B 3 4
  • GPIV 3 4
  • FAT 3 4
  • GP4 3 4
  • Scavenger Receptor Class B, Member 3 3
  • Platelet Collagen Receptor 4
  • Platelet Glycoprotein 4 3
  • Thrombospondin Receptor 4
  • Cluster Determinant 36 3
  • PAS-4 Protein 3
  • CD36 Antigen 4
  • BDPLT10 3
  • SCARB3 3
  • CHDS7 3
  • PASIV 3
  • PAS-4 4

External Ids for CD36 Gene

Previous GeneCards Identifiers for CD36 Gene

  • GC07P078803
  • GC07P078534
  • GC07P079829
  • GC07P079880
  • GC07P079887
  • GC07P079876
  • GC07P080069
  • GC07P074834

Summaries for CD36 Gene

Entrez Gene Summary for CD36 Gene

  • The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CD36 Gene

CD36 (CD36 Molecule) is a Protein Coding gene. Diseases associated with CD36 include Platelet Glycoprotein Iv Deficiency and Coronary Heart Disease 7. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include lipid binding and low-density lipoprotein particle binding. An important paralog of this gene is SCARB2.

UniProtKB/Swiss-Prot for CD36 Gene

  • Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellulare calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).

  • (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.

Gene Wiki entry for CD36 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD36 Gene

Genomics for CD36 Gene

Regulatory Elements for CD36 Gene

Enhancers for CD36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F080310 1 Ensembl ENCODE 11.6 -57.3 -57291 3.1 ELF3 ZNF680 FOXA3 JUN BHLHE40 RFX3 SCRT2 ZNF600 FOXP2 HOMEZ CD36 GNAI1 ENSG00000234223 RN7SL869P
GH07F080307 0.2 ENCODE 11.6 -61.9 -61936 0.2 RFX1 CD36 ENSG00000234223 RN7SL869P
GH07F080263 0.2 ENCODE 11.5 -106.0 -106036 0.2 CD36 RN7SL869P ENSG00000234223
GH07F080324 0.8 ENCODE 11.4 -45.3 -45336 0.2 JUND STAT1 JUN CEBPB STAT3 SIN3A EP300 CD36 RN7SL35P LOC105375373
GH07F080244 0.2 ENCODE 11.4 -124.8 -124840 1.1 SMARCA4 POLR2A CD36 GNAI1 RN7SL869P GC07P080218 GC07P080219
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CD36 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD36 Gene

Chromosome:
7
Start:
80,369,575 bp from pter
End:
80,679,277 bp from pter
Size:
309,703 bases
Orientation:
Plus strand

Genomic View for CD36 Gene

Genes around CD36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD36 Gene

Proteins for CD36 Gene

  • Protein details for CD36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16671-CD36_HUMAN
    Recommended name:
    Platelet glycoprotein 4
    Protein Accession:
    P16671
    Secondary Accessions:
    • D9IX66
    • D9IX67
    • D9IX68
    • D9IX69
    • Q13966
    • Q16093
    • Q8TCV7
    • Q9BPZ8
    • Q9BQC2
    • Q9BZM8
    • Q9BZN3
    • Q9BZN4
    • Q9BZN5

    Protein attributes for CD36 Gene

    Size:
    472 amino acids
    Molecular mass:
    53053 Da
    Quaternary structure:
    • Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (PubMed:1371676). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4:TLR6 heterodimerization and signal initiation (PubMed:1371676, PubMed:20037584). Upon interaction with ligands such as diacylated lipopeptides, interacts with the TLR2:TLR6 heterodimer (PubMed:16880211). Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (By similarity).
    SequenceCaution:
    • Sequence=AAM14636.2; Type=Frameshift; Positions=53; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CD36 Gene

    Alternative splice isoforms for CD36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD36 Gene

Post-translational modifications for CD36 Gene

  • N-glycosylated and O-glycosylated with a ratio of 2:1.
  • Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783).
  • Glycosylation at Asn 79, Asn 102, Asn 134, Asn 163, Asn 205, Asn 220, Asn 235, Asn 247, Asn 321, and Asn 417
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD36 Gene

Domains & Families for CD36 Gene

Gene Families for CD36 Gene

Graphical View of Domain Structure for InterPro Entry

P16671

UniProtKB/Swiss-Prot:

CD36_HUMAN :
  • Belongs to the CD36 family.
Family:
  • Belongs to the CD36 family.
genes like me logo Genes that share domains with CD36: view

Function for CD36 Gene

Molecular function for CD36 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD36 (platelet GPIV),85kDa,adhesive cell surface,single glycoprotein,identified by monoclonal antibodies TP85,SMO,ESIVC7,5F1,CD38,expressed in various epithelial and endothelial cells and in erythrocytes
UniProtKB/Swiss-Prot Function:
Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellulare calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.

Gene Ontology (GO) - Molecular Function for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity TAS 9568716
GO:0005515 protein binding IPI 16880211
GO:0008035 high-density lipoprotein particle binding IEA --
GO:0008289 lipid binding IDA 10772654
GO:0030169 low-density lipoprotein particle binding IDA 10772654
genes like me logo Genes that share ontologies with CD36: view
genes like me logo Genes that share phenotypes with CD36: view

Human Phenotype Ontology for CD36 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD36 Gene

MGI Knock Outs for CD36:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD36

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD36

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD36 Gene

Localization for CD36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD36 Gene

Cell membrane; Multi-pass membrane protein. Membrane raft. Golgi apparatus. Apical cell membrane. Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis. {ECO:0000269 PubMed:20037584}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD36 Gene COMPARTMENTS Subcellular localization image for CD36 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005794 Golgi apparatus IEA,IDA 16880211
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 9568716
genes like me logo Genes that share ontologies with CD36: view

Pathways & Interactions for CD36 Gene

genes like me logo Genes that share pathways with CD36: view

Gene Ontology (GO) - Biological Process for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001954 positive regulation of cell-matrix adhesion IDA 17416590
GO:0002221 pattern recognition receptor signaling pathway IEA --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002576 platelet degranulation TAS --
genes like me logo Genes that share ontologies with CD36: view

No data available for SIGNOR curated interactions for CD36 Gene

Drugs & Compounds for CD36 Gene

(78) Drugs for CD36 Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ABT-510 Investigational Pharma 0
Anticholesteremic Agents Pharma 1983
Anticoagulants Pharma 2516
Antimetabolites Pharma 11774
Atorvastatin Calcium Pharma HMG-CoA reductase inhibitor 743

(59) Additional Compounds for CD36 Gene - From: Novoseek and HMDB