Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD34 Gene

protein-coding GIFtS: 70
GCID: GC01M208057

CD34 molecule

(Previous name: CD34 antigen )

Explore 142 diseases affiliated with
CD34 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD34 Molecule¹ ²
CD34 Antigen¹ ² ³
Hematopoietic Progenitor Cell Antigen CD34²

External Ids:	HGNC: 1662¹	Entrez Gene: 947²	Ensembl: ENSG00000174059⁷	OMIM: 142230⁵	UniProtKB: P28906³

Export aliases for CD34 gene to outside databases

Previous GC identifers: GC01M206701 GC01M203770 GC01M204701 GC01M205143 GC01M204432 GC01M206116 GC01M178734

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD34:

The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular

matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein

kinase C. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug

2011)

UniProtKB/Swiss-Prot: CD34_HUMAN, P28906

Function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to

the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of

lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow

components. Presents carbohydrate ligands to selectins

Gene Wiki entry for CD34

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD34 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CD34 promoter sequence

Search SABiosciences Chromatin IP Primers for CD34

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD34

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32

CD34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD34 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M208057: view genomic region (about GC identifiers)

Start:	208,057,594 bp from pter	End:	208,084,747 bp from pter
Size:	27,154 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD34_HUMAN, P28906 (See protein sequence)

Recommended Name: Hematopoietic progenitor cell antigen CD34 precursor

Size: 385 amino acids; 40716 Da

Subcellular location: Membrane; Single-pass type I membrane protein

Developmental stage: On early hematopoietic progenitor cells

Sequence caution: Sequence=AAA03181.1; Type=Erroneous initiation;

Secondary accessions: A8K664 Q15970 Q15971 Q5JTA3 Q5JTA4 Q9UJB1

Alternative splicing: 2 isoforms: P28906-1 P28906-2

Explore the universe of human proteins at neXtProt for CD34: NX_P28906

Post-translational modifications:

Highly glycosylated¹

Phosphorylated on serine residues by PKC¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P28906

CD34 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001020280.1 NP_001764.1

ENSEMBL proteins:

ENSP00000310036 ENSP00000348916 ENSP00000356003 ENSP00000442874

Reactome Protein details: P28906
Human Recombinant Protein Products for CD34:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CD34
	OriGene Purified Protein: CD34 OriGene Protein Over-expression Lysate (see all 3): CD34 OriGene Custom Protein Services for CD34
	GenScript Custom Purified and Recombinant Proteins Services for CD34
	Novus Biologicals CD34 Proteins Novus Biologicals CD34 Lysates
	Sino Biological Recombinant Protein for CD34
	ProSpec Recombinant Protein for CD34
	Uscn Proteins for CD34

Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005737	cytoplasm	IDA	7525669
GO:0005764	lysosome	ISS	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9042286

CD34 for ontologies About GeneDecksing

CD34 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD34
	R&D Systems Antibodies for CD34
	Cell Signaling Technology (CST) Antibodies for CD34
	OriGene Antibodies (see all 2): CD34 OriGene Custom Antibody Services for CD34
	GenScript Custom Superior Antibodies Services for CD34
	Novus Biologicals CD34 Antibodies
	Abcam antibodies for CD34
	Uscn Antibodies for CD34
	ThermoFisher Antibody for CD34

Assay Products for CD34:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD34
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD34

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD34 for domains About GeneDecksing

2 InterPro domains/families:

IPR013836 CD34/Podocalyxin

IPR008083 CD34

Graphical View of Domain Structure for InterPro Entry P28906

ProtoNet protein and cluster: P28906

2 Blocks protein families:

IPB008083 CD34 antigen signature

IPB013836 CD34/Podocalyxin

UniProtKB/Swiss-Prot: CD34_HUMAN, P28906

Similarity: Belongs to the CD34 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CD34_HUMAN, P28906

Function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to

the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of

lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow

components. Presents carbohydrate ligands to selectins

Genatlas biochemistry entry for CD34:

cell differentiation antigen CD34,105-120kDa,transmembrane glycoprotein,single chain,identified by monoclonal

antibodies My10,BI-3C5,ICH-3,12.8,cytokine low-responding circulating haemopoietic progenitor,expressed by small

vessel endothelial cells

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008134	transcription factor binding	IPI	--
GO:0030246	carbohydrate binding	IDA	15249540
GO:0043199	sulfate binding	IEA	--

CD34 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CD34:

Decreased POU5F1-GFP protein e

Increased gamma-H2AX phosphory

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cd34):

cellular	hematopoietic system	homeostasis/metabolism	immune system	integument
tumorigenesis

CD34 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CD34: Cd34^tm1Szk Cd34^tm1Lal

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD34

miRNA Products:		miRTarBase miRNAs that target CD34: hsa-mir-125a-5p (MIRT004052)

		OriGene 3'-UTR Clone (see all 2): CD34 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD34
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CD34 (see all 9):
		hsa-miR-875-3p hsa-miR-330-5p hsa-miR-765 hsa-miR-16-1* hsa-miR-138-2* hsa-miR-326 hsa-miR-1299 hsa-miR-616

		SwitchGear 3'UTR luciferase reporter plasmid: CD34 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD34 (see all 7) OriGene shRNA RFP: CD34 OriGene siRNA: CD34
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD34
		Sirion Biotech Custom design and validation of potent shRNA sequences against CD34

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CD34
			Sirion Biotech Customized adenovirus for overexpression of CD34 Sirion Biotech Customized adenovirus for potent knockdown of CD34

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD34 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD34 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD34 (NM_001773)
		Sino Biological Human cDNA Clone for CD34
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD34
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD34

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD34
		Search LifeMap BioReagents cell lines for CD34
		Sirion Biotech Customized stable knockdown cell line services for CD34 Sirion Biotech Customized inducible knockdown cell line services for CD34 Sirion Biotech Customized stable overexpressing cell line services for CD34 Sirion Biotech Customized inducible overexpressing cell line services for CD34

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD34

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Lymphocyte Signaling

Lymphocyte Signaling

1.00

C-MYB transcription factor network

C-MYB transcription factor network

1.00

Hematopoietic cell lineage

Hematopoietic cell lineage

1.00

Cell adhesion molecules (CAMs)

Cell adhesion molecules (CAMs)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for CD34

Lymphocyte Signaling

1 BioSystems Pathway for CD34

C-MYB transcription factor network

3 Reactome Pathways for CD34

	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Adaptive Immune System
	Immune System

2 Kegg Pathways (Kegg details for CD34):

	Cell adhesion molecules (CAMs)
	Hematopoietic cell lineage

CD34 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD34

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/8 Interacting proteins for CD34 (P28906³ ENSP00000310036⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRKL	P46109³, ENSP00000346300⁴	I2D: score=2 STRING: ENSP00000346300
CREM	Q03060³, ENSP00000265372⁴	I2D: score=1 STRING: ENSP00000265372
PRKCD	Q05655³, ENSP00000331602⁴	I2D: score=1 STRING: ENSP00000331602
ATF5	Q9Y2D1³	I2D: score=1
MYB	ENSP00000339992⁴	STRING: ENSP00000339992

About this table

Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001894	tissue homeostasis	IDA	12939361
GO:0001935	endothelial cell proliferation	IDA	--
GO:0003094	glomerular filtration	IEP	--
GO:0003158	endothelium development	IEP	17261663
GO:0006536	glutamate metabolic process	IDA	17505307

CD34 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD34 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD34
10/19 Novoseek chemical compound relationships for CD34 gene (see all 19) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chymopapain	65.1	1	15379265 (1)
methylcellulose	55.3	1	7681783 (1)
4-hydroperoxycyclophosphamide	44.7	1	1281782 (1)
paraffin	41.6	8	16911464 (1), 16049289 (1), 17498596 (1), 8732185 (1) (see all 8)
reticulin	32.9	2	11783914 (1), 7681701 (1)
fluorochrome	31.6	1	10791905 (1)
vegf	29.9	18	12829126 (3), 17687613 (3), 17311868 (2), 17185121 (2) (see all 10)
fitc	23.5	2	7522715 (1), 1724439 (1)
percoll	21.9	1	8123456 (1)
rhodamine 123	16.2	2	7507857 (1)

Search CenterWatch for drugs/clinical trials and news about CD34

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD34 gene (2 alternative transcripts):

NM_001025109.1 NM_001773.2

Unigene Cluster for CD34:

CD34 molecule

Hs.374990 [show with all ESTs]

Unigene Representative Sequence: BX640941

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000485761 ENST00000310833(uc001hgw.1 uc010psj.1) ENST00000356522(uc001hgx.1)

ENST00000367036(uc001hgv.1) ENST00000537704

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD34 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD34
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CD34 (see all 9):
		hsa-miR-875-3p hsa-miR-330-5p hsa-miR-765 hsa-miR-16-1* hsa-miR-138-2* hsa-miR-326 hsa-miR-1299 hsa-miR-616

		SwitchGear 3'UTR luciferase reporter plasmid: CD34 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD34 (see all 7) OriGene shRNA RFP: CD34 OriGene siRNA: CD34
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD34
		Sirion Biotech Custom design and validation of potent shRNA sequences against CD34

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD34 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD34 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD34 (NM_001773)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD34
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD34

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD34 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CD34
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD34
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD34

Additional cDNA sequence:

AF202879.1 AF523361.1 AF538601.1 AK091890.1 AK291529.1 AK293030.1 AK294381.1 AK300835.1

BC039146.1 BX538076.1 BX640941.1 M81104.1 S53910.1 S53911.1

14 DOTS entries:

DT.447928 DT.100820367 DT.91744908 DT.121449830 DT.100650592 DT.100840811 DT.97825998 DT.100000188

DT.121449820 DT.100820362 DT.121449831 DT.447927 DT.99981405 DT.95274936

24/203 AceView cDNA sequences (see all 203):

BP343062 BP343630 AU121843 AL572644 CR603236 H01096 AI432610 AW014274

AI017793 CR610477 AF523361 AU141111 BQ879815 AF538601 W58493 BQ880710

AI688653 BE677587 AF202879 AI970362 CB051329 AI017002 BM681806 AU141125

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CD34 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14
SP1:																							-																-
SP2:																							-
SP3:															-		-		-				-																-		-		-
SP4:																	-		-		-		-		-		-
SP5:																																							-

ECgene alternative splicing isoforms for CD34

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTCCTCCT

About this image

CD34 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/42 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 42)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Peripheral Blood

B-cell Progenitor Cells

Selective marker (cell-identifying gene)

Blood

Peripheral Blood

Common Myeloid Progenitor Cells

Blood

Peripheral Blood

Erythroid Progenitor Cells

Blood

Peripheral Blood

Granulocyte-Monocyte Progenitor Cells

Blood

Peripheral Blood

Megakaryocyte-Erythroid Precursor Cells

Blood

Blood

Hematopoietic Stem Cells

Blood

Endothelium

Arteries

Endothelial tip cells

Endothelium

Extraembryonic Mesoderm

Extraembryonic Blood Islands

Extraembryonic Angioblasts

Endothelium

Lateral Plate Mesoderm

Aorta-Gonad-Mesonephros

Hematopoietic Stem Cells

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/52 LifeMap Cells (see all 52)

Name

Category

Peripheral blood/mobilized hematopoietic stem cells (Adult Stem / Progenitor Cell)

Blood

Bone marrow-derived ALDH+ cells (ALD) (Adult Stem / Progenitor Cell)

Bone

Bone marrow-derived CD34+ stem cells (ACT34) (Adult Stem / Progenitor Cell)

Bone

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

Endothelial progenitor cells (Adult Stem / Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Hematopoietic stem cells (Umbilical Cord) (Fetal Stem / Progenitor Cell)

Blood, Extraembryonic Tissues

See CD34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD34

SOURCE GeneReport for Unigene cluster: Hs.374990

UniProtKB/Swiss-Prot: CD34_HUMAN, P28906

Tissue specificity: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a

variety of tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including CD34 (see all 7):

Cell Surface Markers in human mouse rat

Cell Lineage Identification in human mouse rat

Th17 Response in human mouse rat

Leukemia in human mouse rat

Lymphoma in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD34 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CD34
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD34
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD34

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD34

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD34 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cd34^{1 , 5}	CD34 antigen^{1, 5}	76.49(n)¹ 65.79(a)¹		1 (98.38 cM)⁵ 12490¹ NM_133654.3¹ NP_598415.1¹ 194938821⁵
chicken (Gallus gallus)	Aves	CD34¹	CD34 molecule	50.75(n) 39.47(a)		419856 XM_417984.3 XP_417984.3
lizard (Anolis carolinensis)	Reptilia	CD34⁶	--	42(a)	1 ↔ 1	GL343255.1(1809293-1828171)

ENSEMBL Gene Tree for CD34 (if available)
TreeFam Gene Tree for CD34 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2785644^1,2	C,A,H	--	208059691(+)	`TCTCCC/TCATGG`	2	--	ds500¹ trp³		5		NA WA	244
rs187100772^1,2		--	208059754(+)	`CTGTGC/TCTGCT`	2	--	ds500¹		0	--	--	--	--
rs201329647^1,2		--	208059767(+)	`GTGCT-/CCACCCTC`	2	--	ds500¹		0	--	--	--	--
rs3043877^1,2	C	--	208059768(-)	`AGAGG-/TTGGAGCA`	2	--	ds500¹ trp³		0	--	--	--	--
rs7535242^1,2	C,F,H	--	208059958(+)	`ATACTC/GTCTTC`	2	--	ut3¹ ese³ trp³		6		NS EA WA	528
rs7572^1,2	C,F,H	--	208060009(+)	`CCCTGC/TTCAAC`	2	--	ut3¹ ese³		31		MN EA NA NS WA	4850
rs142555957^1,2		--	208060231(+)	`GCCATG/TGAGAT`	2	--	ut3¹		0	--	--	--	--
rs144878009^1,2		--	208060253(+)	`GCTAGA/GATCCA`	2	--	ut3¹		0	--	--	--	--
rs41274808^1,2		--	208060295(+)	`ACAGGC/TGAGAG`	2	--	ut3¹		0	--	--	--	--
rs2556^1,2	C,F,H	--	208060359(+)	`AAAAAG/AGAGCC`	2	--	ut3¹ ese³ trp³		23		MN EA NA NS WA	4572

HapMap Linkage Disequilibrium report for CD34 (208057594 - 208084747 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD34: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD34

DNA2.0 Custom Variant and Variant Library Synthesis for CD34

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD34 for disorders           About GeneDecksing

OMIM gene information: 142230    OMIM disorders: --

20/142 diseases for CD34 (see all 142):    About MalaCards

spinal cord injury dermatofibrosarcoma protuberans fibrous histiocytoma sweat gland neoplasm

hypersensitivity reaction type ii disease kaposiform hemangioendothelioma human immunodeficiency virus infectious disease gastrointestinal stromal tumor

hemangioendothelioma cutaneous fibrous histiocytoma spindle cell lipoma pleomorphic xanthoastrocytoma

malignant fibrous histiocytoma classic kaposi sarcoma pre-eclampsia androgenetic alopecia

atypical neurofibroma capillary hemangioma dermatofibrosarcoma non-hodgkin lymphoma

20/39 diseases from the University of Copenhagen DISEASES database for CD34 (see all 39):

Leukemia Myeloma Lymphoma Gastrointestinal stromal tumor

Hemangiopericytoma Sarcoma Fibrosarcoma Severe combined immunodeficiency

Mesenchymal cell neoplasm Cutaneous fibrous histiocytoma Anemia Neutropenia

Carcinoma Lipoma Thrombocytopenia Vascular cancer

Leiomyosarcoma Breast cancer Perineurioma Neurilemmoma

10/79 Novoseek disease relationships for CD34 gene (see all 79) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dermatofibrosarcoma protuberans	74.3	7	7681857 (1), 7506274 (1), 9042286 (1), 17595787 (1) (see all 7)
secondary aml	67.5	4	8895688 (2), 9058027 (1), 1702006 (1)
gastrointestinal stromal tumor	66.3	7	9001869 (1), 7530409 (1), 10751339 (1), 9042286 (1) (see all 6)
aml adult	64.4	1	7526090 (1)
acute leukemia	58.7	10	19454497 (2), 9001869 (1), 1712541 (1), 7505888 (1) (see all 9)
b-all	54.1	4	8726408 (1), 11583283 (1), 15363127 (1)
stromal tumors	52	2	10760321 (1), 15223969 (1)
dermatofibroma	51.8	2	9129699 (1), 9179057 (1)
hemangiopericytoma	51.7	5	15309019 (3), 1712541 (1)
myeloid leukemia chronic	51.4	5	8672965 (1), 10779436 (1), 1713638 (1), 7512785 (1) (see all 5)

Genetic Association Database (GAD): CD34
Human Genome Epidemiology (HuGE) Navigator: CD34 (29 documents)

Export disorders for CD34 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD34 gene, integrated from 9 sources (see all 537):
(articles sorted by number of sources associating them with CD34)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells. (PubMed id 1370171)^{1, 2, 3, 9} Simmons D.L.... Seed B. (1992)
Structure of the gene encoding CD34, a human hematopoietic stem cell antigen. (PubMed id 1374051)^{1, 2, 3} Satterthwaite A.B.... Tenen D.G. (1992)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
Two alternative forms of cDNA encoding CD34. (PubMed id 7678811)^{1, 2} Nakamura Y.... Nakauchi H. (1993)
Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells. (PubMed id 1694174)^{1, 2} Fackler M.J.... May W.S. (1990)
Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34. (PubMed id 2462139)^{1, 2} Sutherland D.R.... Smart J.E. (1988)
Expression of the CD34 gene in vascular endothelial cells. (PubMed id 1693532)^{1, 9} Fina L....Greaves M.F. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 947	HGNC: 1662	AceView: CD34	Ensembl:ENSG00000174059	euGenes: HUgn947
ECgene: CD34	Kegg: 947	H-InvDB: CD34

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD34	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD34	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/CD34

Intellectual Property for CD34 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CD34 gene:
Search GeneIP for patents involving CD34

Licensable Technologies for CD34 gene:

Weizmann Institute:

Enrichment of Repopulating Stem Cells For Clinical Protocols

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD34
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CD34 (CD34)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents for CD34 (CD34)		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for CD34		OriGene shRNA RFP for CD34
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD34		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD34
	OriGene Protein Over-expression Lysate for CD34		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CD34		OriGene 3'-UTR Clone for CD34
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD34		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD34
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CD34		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CD34		OriGene Custom Protein Services for CD34
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD34
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD34
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD34
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD34
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD34
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD34

	GenScript Custom Purified and Recombinant Proteins Services for CD34		GenScript cDNA clones with any tag delivered in your preferred vector for CD34
	GenScript Custom Assay Services for CD34		GenScript Custom Superior Antibodies Services for CD34
	GenScript Custom overexpressing Cell Line Services for CD34		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for CD34

	Regulatory tfbs in CD34 promoter
	Search Chromatin IP Primers for CD34
	RT² qPCR Primer Assay in human, mouse, rat CD34
	GNC Network for CD34
	SABiosciences PCR Arrays including human, mouse, rat CD34

Search Tocris compounds for CD34

	Proteins and Antibodies for CD34
	cDNA Clones for CD34
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Proteins for CD34
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CD34 antibodies
	CD34 proteins
	CD34 lysates

	Antibodies for CD34
	See all of Abcam's Antibodies, Kits and Proteins for CD34
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for CD34

CD34 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CD34

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD34

	SwitchGear 3'UTR luciferase reporter plasmids for CD34
	SwitchGear Promoter luciferase reporter plasmids for CD34

ThermoFisher Antibody for CD34

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD34

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD34

Sirion Biotech Customized:

	stable knockdown cell line services for CD34
	inducible knockdown cell line services for CD34
	design and validation of potent shRNA sequences against CD34
	adenovirus for potent knockdown of CD34
	adenovirus for overexpression of CD34
	stable overexpressing cell line services for CD34
	inducible overexpressing cell line services for CD34

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CD34 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CD34 Gene

CD34 molecule

Aliases
for CD34 gene

Summaries
for CD34 gene

Genomic Views
for CD34 gene

Proteins
for CD34 gene

Protein Domains /
Families
for CD34 gene

Function
for CD34 gene

Pathways & Interactions
for CD34 gene

Drugs & Compounds
for CD34 gene

Transcripts
for CD34 gene

Expression
for CD34 gene

Orthologs
for CD34 gene

Paralogs
for CD34 gene

Genomic Variants
for CD34 gene

Disorders / Diseases
for CD34 gene

Publications
for CD34 gene

External Searches for CD34 gene

Genome Databases showing CD34 gene

Other Databases showing CD34 gene

Specialized Databases showing CD34 gene

Intellectual Property
for CD34 gene

Products
for CD34 gene

View Random Gene

Hemangioendothelioma
Lymphoblastic Leukemia Acute Childhood
Kaposi Sarcoma
Carcinoma Basal Cell
Hemangiopericytoma
dysplasia
Aplasia
Liver diseases
Breast Cancer
Metaplasia
primary tumor
Adenocarcinoma
Cancer
Thrombocytopenia
GASTRITIS CHRONIC
Sarcoma Epithelioid
NEUROMA TRAUMATIC
Nevi
GASTRIC CARCINOMA
Ovarian Cancer
Colorectal Cancer
Fibroma
Leiomyoma
Inflammation
Hamartoma
TUMOR LIVER
immunodeficiency
ENDOMETRIAL CARCINOMA
prostate cancer
Tumors
gastrointestinal stromal tumor
Metastasis
Vascular Neoplasms
Lymphoblastic Leukemia Acute
Sarcoma
MPNST
Lymphangioma
Gastric Cancer
Cirrhosis
Myeloid Leukemia
Leukemia Nonlymphocytic Acute
Lipoma
Hemangioma
Angiosarcoma
Malignant Peripheral Nerve Sheath Tumors
Dermatofibroma
Hyperplasia
Monosomy
Histiocytoma Fibrous
Fibromatosis
B-ALL
ACUTE LEUKEMIA
Karyotype Abnormal
Liposarcoma
Leukemia
Myeloid Leukemia Chronic
Neurofibroma
HEPATOCELLULAR CARCINOMA
AML adult
Meningioma
Hemangioendothelioma Epithelioid
T-ALL
Bleeding
benign tumor
mesothelioma
solid tumor
Carcinoma Squamous Cell
Angiofibroma
Schwannoma
secondary AML
Chromosomal Aberrations
Anemia Aplastic
DERMATOFIBROSARCOMA PROTUBERANS
stromal tumors
leukemogenesis
Lymphoma Non-Hodgkins
Leiomyosarcoma
Granuloma Pyogenic
Myelodysplastic Syndromes

Advanced Search

Export list of displayed genes

CD34 Gene

CD34 molecule

Aliasesfor CD34 gene

Summariesfor CD34 gene

Genomic Viewsfor CD34 gene

Proteinsfor CD34 gene

Protein Domains /Familiesfor CD34 gene

Functionfor CD34 gene

Pathways & Interactionsfor CD34 gene

Drugs & Compoundsfor CD34 gene

Transcriptsfor CD34 gene

Expression for CD34 gene

Orthologsfor CD34 gene

Paralogsfor CD34 gene

Genomic Variantsfor CD34 gene

Disorders / Diseasesfor CD34 gene

Publicationsfor CD34 gene

External Searches for CD34 gene

Genome Databases showing CD34 gene

Other Databases showing CD34 gene

Specialized Databases showing CD34 gene

Intellectual Propertyfor CD34 gene

Productsfor CD34 gene

View Random Gene

Aliases
for CD34 gene

Summaries
for CD34 gene

Genomic Views
for CD34 gene

Proteins
for CD34 gene

Protein Domains /
Families
for CD34 gene

Function
for CD34 gene

Pathways & Interactions
for CD34 gene

Drugs & Compounds
for CD34 gene

Transcripts
for CD34 gene

Expression
for CD34 gene

Orthologs
for CD34 gene

Paralogs
for CD34 gene

Genomic Variants
for CD34 gene

Disorders / Diseases
for CD34 gene

Publications
for CD34 gene

Intellectual Property
for CD34 gene

Products
for CD34 gene