External Ids for CD34 Gene
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD34 Gene
CD34 (CD34 Molecule) is a Protein Coding gene. Diseases associated with CD34 include atypical neurofibroma and middle ear squamous cell carcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include transcription factor binding and sulfate binding.
UniProtKB/Swiss-Prot for CD34 Gene
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins