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Aliases for CD34 Gene

Aliases for CD34 Gene

  • CD34 Molecule 2 3
  • CD34 Antigen 2 4

External Ids for CD34 Gene

Previous GeneCards Identifiers for CD34 Gene

  • GC01M206701
  • GC01M203770
  • GC01M204701
  • GC01M205143
  • GC01M204432
  • GC01M206116
  • GC01M208057
  • GC01M178734

Summaries for CD34 Gene

Entrez Gene Summary for CD34 Gene

  • The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD34 Gene

CD34 (CD34 Molecule) is a Protein Coding gene. Diseases associated with CD34 include atypical neurofibroma and middle ear squamous cell carcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include transcription factor binding and sulfate binding.

UniProtKB/Swiss-Prot for CD34 Gene

  • Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins

Gene Wiki entry for CD34 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD34 Gene

Genomics for CD34 Gene

Regulatory Elements for CD34 Gene

Transcription factor binding sites by QIAGEN in the CD34 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD34 Gene

Start:
207,880,972 bp from pter
End:
207,911,402 bp from pter
Size:
30,431 bases
Orientation:
Minus strand

Genomic View for CD34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD34 Gene

Proteins for CD34 Gene

  • Protein details for CD34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28906-CD34_HUMAN
    Recommended name:
    Hematopoietic progenitor cell antigen CD34
    Protein Accession:
    P28906
    Secondary Accessions:
    • A8K664
    • Q15970
    • Q15971
    • Q5JTA3
    • Q5JTA4
    • Q9UJB1

    Protein attributes for CD34 Gene

    Size:
    385 amino acids
    Molecular mass:
    40716 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA03181.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CD34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD34 Gene

Proteomics data for CD34 Gene at MOPED

Post-translational modifications for CD34 Gene

Other Protein References for CD34 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD34 (CD34)

No data available for DME Specific Peptides for CD34 Gene

Domains for CD34 Gene

Gene Families for CD34 Gene

HGNC:
  • CD :CD molecules

Protein Domains for CD34 Gene

Graphical View of Domain Structure for InterPro Entry

P28906

UniProtKB/Swiss-Prot:

CD34_HUMAN :
  • P28906
Family:
  • Belongs to the CD34 family.
genes like me logo Genes that share domains with CD34: view

Function for CD34 Gene

Molecular function for CD34 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD34,105-120kDa,transmembrane glycoprotein,single chain,identified by monoclonal antibodies My10,BI-3C5,ICH-3,12.8,cytokine low-responding circulating haemopoietic progenitor,expressed by small vessel endothelial cells
UniProtKB/Swiss-Prot Function:
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins

Gene Ontology (GO) - Molecular Function for CD34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 21873977
GO:0030246 carbohydrate binding IDA 15249540
GO:0043199 sulfate binding IEA --
genes like me logo Genes that share ontologies with CD34: view
genes like me logo Genes that share phenotypes with CD34: view

Animal Models for CD34 Gene

MGI Knock Outs for CD34:

Animal Model Products

miRNA for CD34 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD34

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD34 Gene

Localization for CD34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD34 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD34 Gene COMPARTMENTS Subcellular localization image for CD34 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 4
lysosome 4
vacuole 4
nucleus 3
endoplasmic reticulum 2
mitochondrion 2
cytosol 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CD34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005737 cytoplasm IDA 7525669
GO:0005764 lysosome ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9042286
genes like me logo Genes that share ontologies with CD34: view

Pathways for CD34 Gene

genes like me logo Genes that share pathways with CD34: view

Pathways by source for CD34 Gene

1 Cell Signaling Technology pathway for CD34 Gene
1 BioSystems pathway for CD34 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for CD34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001894 tissue homeostasis IDA 12939361
GO:0001935 endothelial cell proliferation IDA 21835908
GO:0003094 glomerular filtration IEP 20354148
GO:0003158 endothelium development IEP 17261663
GO:0007155 cell adhesion --
genes like me logo Genes that share ontologies with CD34: view

Compounds for CD34 Gene

(1) ApexBio Compounds for CD34 Gene

Compound Action Cas Number
UM 171 HSC agonist [1448724-09-1]

(19) Novoseek inferred chemical compound relationships for CD34 Gene

Compound -log(P) Hits PubMed IDs
chymopapain 65.1 1
methylcellulose 55.3 1
4-hydroperoxycyclophosphamide 44.7 1
paraffin 41.6 8
reticulin 32.9 2
genes like me logo Genes that share compounds with CD34: view

Transcripts for CD34 Gene

Unigene Clusters for CD34 Gene

CD34 molecule:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD34

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD34 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: -
SP3: - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - -
SP7: -
SP8: - - - - -
SP9:

Relevant External Links for CD34 Gene

GeneLoc Exon Structure for
CD34
ECgene alternative splicing isoforms for
CD34

Expression for CD34 Gene

mRNA expression in normal human tissues for CD34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CD34 Gene

This gene is overexpressed in Seminal vesicle (7.0), Cervix (6.7), and Oral epithelium (6.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD34 Gene

SOURCE GeneReport for Unigene cluster for CD34 Gene Hs.374990

mRNA Expression by UniProt/SwissProt for CD34 Gene

P28906-CD34_HUMAN
Tissue specificity: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues
genes like me logo Genes that share expressions with CD34: view

Expression partners for CD34 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CD34 Gene

Orthologs for CD34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD34 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD34 35
  • 75.96 (n)
  • 64.88 (a)
CD34 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD34 35
  • 80.24 (n)
  • 71.28 (a)
CD34 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd34 35
  • 76.54 (n)
  • 66.4 (a)
Cd34 16
Cd34 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD34 35
  • 99.05 (n)
  • 97.92 (a)
CD34 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd34 35
  • 76.25 (n)
  • 65.7 (a)
oppossum
(Monodelphis domestica)
Mammalia CD34 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD34 36
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD34 36
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD34 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC779603 35
  • 49.46 (n)
  • 37.99 (a)
Species with no ortholog for CD34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD34 Gene

ENSEMBL:
Gene Tree for CD34 (if available)
TreeFam:
Gene Tree for CD34 (if available)

Paralogs for CD34 Gene

Selected SIMAP similar genes for CD34 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD34: view

No data available for Paralogs for CD34 Gene

Variants for CD34 Gene

Sequence variations from dbSNP and Humsavar for CD34 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2556 -- 207,887,014(+) AAAAA(A/G)GAGCC utr-variant-3-prime
rs7572 -- 207,886,664(+) CCCTG(C/T)TCAAC utr-variant-3-prime
rs526254 -- 207,906,326(+) GGAGA(C/T)AAGTG intron-variant
rs579475 -- 207,898,114(+) GATCT(C/T)GGCTC intron-variant
rs656801 -- 207,904,298(+) TATCT(C/T)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD34 Gene

Variant ID Type Subtype PubMed ID
nsv4243 CNV Insertion 18451855
nsv873133 CNV Gain 21882294

Relevant External Links for CD34 Gene

HapMap Linkage Disequilibrium report
CD34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD34 Gene

Disorders for CD34 Gene

(79) Novoseek inferred disease relationships for CD34 Gene

Disease -log(P) Hits PubMed IDs
dermatofibrosarcoma protuberans 74.3 7
secondary aml 67.5 4
gastrointestinal stromal tumor 66.3 6
aml adult 64.4 1
acute leukemia 58.7 10

Relevant External Links for CD34

Genetic Association Database (GAD)
CD34
Human Genome Epidemiology (HuGE) Navigator
CD34
genes like me logo Genes that share disorders with CD34: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CD34 Gene

Publications for CD34 Gene

  1. Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells. (PMID: 1370171) Simmons D.L. … Seed B. (J. Immunol. 1992) 2 3 4 23
  2. Structure of the gene encoding CD34, a human hematopoietic stem cell antigen. (PMID: 1374051) Satterthwaite A.B. … Tenen D.G. (Genomics 1992) 2 3 4
  3. Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells. (PMID: 1694174) Fackler M.J. … May W.S. (J. Biol. Chem. 1990) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Analysis of primitive CD34- and CD34+ hematopoietic cells from adults: gain and loss of CD34 antigen by undifferentiated cells are closely linked to proliferative status in culture. (PMID: 15277701) Dooley D.C. … Xiao M. (Stem Cells 2004) 3 23

Products for CD34 Gene

Sources for CD34 Gene

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