External Ids for CD34 Gene
Previous GeneCards Identifiers for CD34 Gene
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD34 Gene
CD34 (CD34 Molecule) is a Protein Coding gene. Diseases associated with CD34 include dermatofibrosarcoma protuberans and gastrointestinal stromal tumor. Among its related pathways are Cell adhesion molecules (CAMs) and Hematopoietic cell lineage. GO annotations related to this gene include transcription factor binding and sulfate binding.
UniProtKB/Swiss-Prot for CD34 Gene
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.