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CD34 Gene

protein-coding   GIFtS: 69
GCID: GC01M208057

CD34 Molecule

(Previous name: CD34 antigen)
  See CD34-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD34 Molecule1 2
CD34 Antigen1 2 3
Hematopoietic Progenitor Cell Antigen CD342

External Ids:    HGNC: 16621   Entrez Gene: 9472   Ensembl: ENSG000001740597   OMIM: 1422305   UniProtKB: P289063   

Export aliases for CD34 gene to outside databases

Previous GC identifers: GC01M206701 GC01M203770 GC01M204701 GC01M205143 GC01M204432 GC01M206116 GC01M178734


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD34 Gene:
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular
matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by
protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Aug 2011)

GeneCards Summary for CD34 Gene:
CD34 (CD34 molecule) is a protein-coding gene. Diseases associated with CD34 include atypical neurofibroma, and lymphatic system disease. GO annotations related to this gene include sulfate binding and transcription factor binding.

UniProtKB/Swiss-Prot: CD34_HUMAN, P28906
Function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells
to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment
of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow
components. Presents carbohydrate ligands to selectins

Gene Wiki entry for CD34 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD34 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD34 promoter sequence
   Search Chromatin IP Primers for CD34

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32

CD34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD34 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M208057:  view genomic region     (about GC identifiers)

Start:
208,057,594 bp from pter      End:
208,084,747 bp from pter
Size:
27,154 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD34_HUMAN, P28906 (See protein sequence)
Recommended Name: Hematopoietic progenitor cell antigen CD34 precursor  
Size: 385 amino acids; 40716 Da
Developmental stage: On early hematopoietic progenitor cells
Sequence caution: Sequence=AAA03181.1; Type=Erroneous initiation;
Secondary accessions: A8K664 Q15970 Q15971 Q5JTA3 Q5JTA4 Q9UJB1
Alternative splicing: 2 isoforms:  P28906-1   P28906-2   

Explore the universe of human proteins at neXtProt for CD34: NX_P28906

Explore proteomics data for CD34 at MOPED

Post-translational modifications: 

  • Highly glycosylated1
  • Phosphorylated on serine residues by PKC1
  • Glycosylation2 at Asn36, Asn51, Asn55, Asn85, Asn107, Asn126, Asn142, Asn194, Asn249
  • Modification sites at PhosphoSitePlus

  • See CD34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020280.1  NP_001764.1  

    ENSEMBL proteins: 
     ENSP00000356003   ENSP00000310036   ENSP00000348916   ENSP00000442874  
    Reactome Protein details: P28906

    CD34 Human Recombinant Protein Products:

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    Novus Biologicals CD34 Proteins
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    Sino Biological Recombinant Protein for CD34
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    Cloud-Clone Corp. Proteins for CD34

     
    Search eBioscience for Proteins for CD34 

    CD34 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD34
    R&D Systems Antibodies for CD34
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    Abcam antibodies for CD34
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    LSBio Antibodies in human, mouse, rat for CD34

    CD34 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CD34
    Cloud-Clone Corp. CLIAs for CD34
    Search eBioscience for ELISAs for CD34 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    2 InterPro protein domains:
     IPR013836 CD34/Podocalyxin
     IPR008083 CD34

    Graphical View of Domain Structure for InterPro Entry P28906

    ProtoNet protein and cluster: P28906

    2 Blocks protein domains:
    IPB008083 CD34 antigen signature
    IPB013836 CD34/Podocalyxin


    UniProtKB/Swiss-Prot: CD34_HUMAN, P28906
    Similarity: Belongs to the CD34 family


    Find genes that share domains with CD34           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD34_HUMAN, P28906
    Function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells
    to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment
    of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow
    components. Presents carbohydrate ligands to selectins

         Genatlas biochemistry entry for CD34:
    cell differentiation antigen CD34,105-120kDa,transmembrane glycoprotein,single chain,identified by monoclonal
    antibodies My10,BI-3C5,ICH-3,12.8,cytokine low-responding circulating haemopoietic progenitor,expressed by small
    vessel endothelial cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008134transcription factor binding IPI--
    GO:0030246carbohydrate binding IDA15249540
    GO:0043199sulfate binding IEA--
         
    Find genes that share ontologies with CD34           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CD34:
     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd34):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  integument 
     tumorigenesis 

    Find genes that share phenotypes with CD34           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD34: Cd34tm1Szk Cd34tm1Lal

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD34
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD34

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD34
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD34

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD34:
    hsa-mir-106b-5p (MIRT020428), hsa-mir-24-3p (MIRT030549), hsa-mir-9-5p (MIRT021486), hsa-mir-125a-5p (MIRT004052)

    Block miRNA regulation of human, mouse, rat CD34 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CD34 (see all 9):
    hsa-miR-875-3p hsa-miR-330-5p hsa-miR-765 hsa-miR-16-1* hsa-miR-138-2* hsa-miR-326 hsa-miR-1299 hsa-miR-616
    SwitchGear 3'UTR luciferase reporter plasmidCD34 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD34
    Predesigned siRNA for gene silencing in human, mouse, rat CD34

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CD34 (NM_001773)
    Sino Biological Human cDNA Clone for CD34
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD34
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD34

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD34

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11756) for CD34 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD34_HUMAN, P28906: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytoskeleton4
    lysosome4
    vacuole4
    nucleus3
    endoplasmic reticulum2
    mitochondrion2
    cytosol1
    endosome1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005737cytoplasm IDA7525669
    GO:0005764lysosome ISS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9042286

    Find genes that share ontologies with CD34           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD34 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Lymphocyte Signaling
    Lymphocyte Signaling
    3Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    4Hematopoietic cell lineage
    Hematopoietic cell lineage
    5Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with CD34           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CD34
        Lymphocyte Signaling

    1 BioSystems Pathway for CD34
        C-MYB transcription factor network


    1 Reactome Pathway for CD34
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    2 Kegg Pathways  (Kegg details for CD34):
        Cell adhesion molecules (CAMs)
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD34 (see all 7): 
              Cell Surface Markers in human mouse rat
              Cell Lineage Identification in human mouse rat
              Th17 Response in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CD34

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CD34 (P289063 ENSP000003100364) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKLP461093, ENSP000003463004I2D: score=2 STRING: ENSP00000346300
    CREMQ030603, ENSP000002653724I2D: score=1 STRING: ENSP00000265372
    PRKCDQ056553, ENSP000003316024I2D: score=1 STRING: ENSP00000331602
    ATF5Q9Y2D13I2D: score=1 
    MYBENSP000003399924STRING: ENSP00000339992
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001894tissue homeostasis IDA12939361
    GO:0001935endothelial cell proliferation IDA--
    GO:0003094glomerular filtration IEP--
    GO:0003158endothelium development IEP17261663
    GO:0006536glutamate metabolic process IDA17505307

    Find genes that share ontologies with CD34           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD34

    Selected Novoseek inferred chemical compound relationships for CD34 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chymopapain 65.1 1 15379265 (1)
    methylcellulose 55.3 1 7681783 (1)
    4-hydroperoxycyclophosphamide 44.7 1 1281782 (1)
    paraffin 41.6 8 16911464 (1), 16049289 (1), 17498596 (1), 8732185 (1) (see all 8)
    reticulin 32.9 2 11783914 (1), 7681701 (1)
    fluorochrome 31.6 1 10791905 (1)
    vegf 29.9 18 12829126 (3), 17687613 (3), 17311868 (2), 17185121 (2) (see all 10)
    fitc 23.5 2 7522715 (1), 1724439 (1)
    percoll 21.9 1 8123456 (1)
    rhodamine 123 16.2 2 7507857 (1)



    Find genes that share compounds with CD34           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD34 gene (2 alternative transcripts): 
    NM_001025109.1  NM_001773.2  

    Unigene Cluster for CD34:

    CD34 molecule
    Hs.374990  [show with all ESTs]
    Unigene Representative Sequence: BX640941
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485761 ENST00000367036(uc001hgv.1) ENST00000310833(uc001hgw.1 uc010psj.1)
    ENST00000356522(uc001hgx.1) ENST00000537704
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CD34 (see all 9):
    hsa-miR-875-3p hsa-miR-330-5p hsa-miR-765 hsa-miR-16-1* hsa-miR-138-2* hsa-miR-326 hsa-miR-1299 hsa-miR-616
    SwitchGear 3'UTR luciferase reporter plasmidCD34 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CD34 (NM_001773)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD34
    Primer
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    OriGene qPCR primer pairs and template standards for CD34
    OriGene qSTAR qPCR primer pairs in human, mouse for CD34
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD34
      QuantiTect SYBR Green Assays in human, mouse, rat CD34
      QuantiFast Probe-based Assays in human, mouse, rat CD34
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11756) for CD34 

    Additional mRNA sequence: 

    AF202879.1 AF523361.1 AF538601.1 AK091890.1 AK291529.1 AK293030.1 AK294381.1 AK300835.1 
    BC039146.1 BX538076.1 BX640941.1 M81104.1 S53910.1 S53911.1 

    14 DOTS entries:

    DT.447928  DT.100820367  DT.91744908  DT.121449830  DT.100650592  DT.100840811  DT.97825998  DT.100000188 
    DT.121449820  DT.100820362  DT.121449831  DT.447927  DT.99981405  DT.95274936 

    Selected AceView cDNA sequences (see all 203):

    CR610477 W74409 CR613813 AI688653 BP343062 AI926942 BM681806 AI017002 
    BX100546 BQ880710 BQ879815 AF538601 AI970362 AU141111 AF523361 AI432610 
    H01096 CA435466 CR603236 AI874217 BQ879309 AU121843 AI017793 BP343459 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CD34 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                    -                                               -                                       
    SP2:                                                                    -                                                                                       
    SP3:                                            -     -     -           -                                               -     -     -                           
    SP4:                                                  -     -     -     -     -     -                                                                           
    SP5:                                                                                                                    -                                       


    ECgene alternative splicing isoforms for CD34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CD34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTCCTCCT
    CD34 Expression
    About this image


    CD34 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 37) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 93 entries
             B-cell Progenitor Cells Peripheral Blood
             Umbilical cord blood-derived stem cells (NiCord)
             Hematopoietic progenitor cells
             Bone Marrow CD133+ Cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 45 entries
             Endothelial Tip Cells Arteries
             Peripheral blood-derived endothelial progenitor cells
             Purified endothelial-like cells
             Human Aortic Endothelial Cells (HAEC)   
             mouse/organ system/cardiovascular system/arterial system   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 28 entries
             Mesenchymal Stem Cells Wharton's Jelly
             Umbilical cord blood-derived stem cells (NiCord)
             Human Umbilical Artery Endothelial Cells (HUAEC)   
     
     Thymus (Hematopoietic System)    fully expand to see all 7 entries
             Double Negative 3 Thymocytes Thymus
     
     Adipose (Muscoskeletal System)    fully expand to see all 14 entries
             Stromal Cells Subcutaneous White Adipose
             Adipose-derived stem and regenerative cell
    CD34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD34 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374990

    UniProtKB/Swiss-Prot: CD34_HUMAN, P28906
    Tissue specificity: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a
    variety of tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CD34 (see all 7): 
              Cell Surface Markers in human mouse rat
              Cell Lineage Identification in human mouse rat
              Th17 Response in human mouse rat
              Leukemia in human mouse rat
              Lymphoma in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CD34
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    QuantiFast Probe-based Assays in human, mouse, rat CD34
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD34 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd341 , 5 CD34 antigen1, 5 76.54(n)1
    66.4(a)1
      1 (98.38 cM)5
    124901  NM_133654.31  NP_598415.11 
     1949388215 
    chicken
    (Gallus gallus)
    Aves CD346
    CD34 molecule
    27(a)
    1 ↔ 1
    26(2670687-2678872)
    lizard
    (Anolis carolinensis)
    Reptilia CD346
    CD34 molecule
    35(a)
    1 ↔ 1
    GL343255.1(1786103-1831688)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC7796031 uncharacterized LOC779603 49.46(n)
    37.99(a)
      779603  XM_002938432.1  XP_002938478.1 


    ENSEMBL Gene Tree for CD34 (if available)
    TreeFam Gene Tree for CD34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD34 gene
    1 SIMAP similar gene for CD34 using alignment to 6 protein entries:     CD34_HUMAN (see all proteins):
    DKFZp686I22213

    Find genes that share paralogs with CD34           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD34 (see all 555)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27856441,2
    C,F,A,H--208059691(+) TCTCCC/TCATGG 2 -- ds5001 trp35Minor allele frequency- T:0.23NA WA 244
    rs1871007721,2
    --208059754(+) CTGTGC/TCTGCT 2 -- ds50010--------
    rs2013296471,2
    --208059767(+) GTGCT-/CCACCCTC 2 -- cds10--------
    rs30438771,2
    C--208059768(-) AGAGG-/TTGGAGCA 2 -- cds1 trp30--------
    rs75352421,2
    C,F,H--208059958(+) ATACTC/GTCTTC 2 -- ut31 ese3 trp36Minor allele frequency- G:0.02NS EA WA 528
    rs75721,2
    C,F,H--208060009(+) CCCTGC/TTCAAC 2 -- ut31 ese331Minor allele frequency- N:0.00MN EA NA NS WA 4850
    rs1425559571,2
    --208060231(+) GCCATG/TGAGAT 2 -- ut310--------
    rs1448780091,2
    --208060253(+) GCTAGA/GATCCA 2 -- ut310--------
    rs412748081,2
    C--208060295(+) ACAGGC/TGAGAG 2 -- ut310--------
    rs3735651271,2
    C--208060304(+) AGGCTC/TGCTCC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CD34 (208057594 - 208084747 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD34:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4243CNV Insertion18451855
    nsv873133CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD34
    DNA2.0 Custom Variant and Variant Library Synthesis for CD34

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142230    OMIM disorders: --

    Selected diseases for CD34 (see all 23):    
    About MalaCards
    atypical neurofibroma    lymphatic system disease    kaposiform hemangioendothelioma    adenoid squamous cell carcinoma
    middle ear squamous cell carcinoma    lymphangiomatosis    mesenchymal cell neoplasm    vascular cancer
    chronic neutrophilic leukemia    capillary hemangioma    spindle cell lipoma    cutaneous fibrous histiocytoma
    neurilemmoma    malignant fibroxanthoma    myeloid sarcoma    adult acute lymphocytic leukemia
    kaposi's sarcoma    pleomorphic xanthoastrocytoma    perineurioma    giant cell glioblastoma

    Selected diseases from the University of Copenhagen DISEASES database for CD34 (see all 40):
    Leukemia     Gastrointestinal stromal tumor     Myeloma     Lymphoma
    Hemangiopericytoma     Mesenchymal cell neoplasm     Sarcoma     Fibrosarcoma
    Cutaneous fibrous histiocytoma     Severe combined immunodeficiency     Anemia     Neutropenia
    Lipoma     Carcinoma     Vascular cancer     Leiomyosarcoma
    Thrombocytopenia     Perineurioma     Neurilemmoma     Breast cancer

    Find genes that share disorders with CD34           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD34 gene (see all 79)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dermatofibrosarcoma protuberans 74.3 7 7681857 (1), 7506274 (1), 9042286 (1), 17595787 (1) (see all 7)
    secondary aml 67.5 4 8895688 (2), 9058027 (1), 1702006 (1)
    gastrointestinal stromal tumor 66.3 7 9001869 (1), 7530409 (1), 10751339 (1), 9042286 (1) (see all 6)
    aml adult 64.4 1 7526090 (1)
    acute leukemia 58.7 10 19454497 (2), 9001869 (1), 1712541 (1), 7505888 (1) (see all 9)
    b-all 54.1 4 8726408 (1), 11583283 (1), 15363127 (1)
    stromal tumors 52 2 10760321 (1), 15223969 (1)
    dermatofibroma 51.8 2 9129699 (1), 9179057 (1)
    hemangiopericytoma 51.7 5 15309019 (3), 1712541 (1)
    myeloid leukemia chronic 51.4 5 8672965 (1), 10779436 (1), 1713638 (1), 7512785 (1) (see all 5)

    Genetic Association Database (GAD): CD34
    Human Genome Epidemiology (HuGE) Navigator: CD34 (29 documents)

    Export disorders for CD34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD34 gene, integrated from 10 sources (see all 559):
    (articles sorted by number of sources associating them with CD34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells. (PubMed id 1370171)1, 2, 3, 9 Simmons D.L.... Seed B. (J. Immunol. 1992)
    2. Structure of the gene encoding CD34, a human hematopoietic stem cell antigen. (PubMed id 1374051)1, 2, 3 Satterthwaite A.B.... Tenen D.G. (Genomics 1992)
    3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Genome-wide association analysis identifies multiple loci related to resting heart rate. (PubMed id 20639392)1, 4 Eijgelsheim M....O'Donnell C.J. (Hum. Mol. Genet. 2010)
    6. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. (PubMed id 19817957)1, 4 Segat L....Crovella S. (J. Gastroenterol. Hepatol. 2009)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)1, 4 Saito T....Kawata S. (Biochem. Biophys. Res. Commun. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 947 HGNC: 1662 AceView: CD34 Ensembl:ENSG00000174059 euGenes: HUgn947
    ECgene: CD34 Kegg: 947 H-InvDB: CD34

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD34 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD34 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/CD34

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD34 gene:
    Search GeneIP for patents involving CD34

    Licensable Technologies for CD34 gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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