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Aliases for CD33 Gene

Aliases for CD33 Gene

  • CD33 Molecule 2 3 5
  • Sialic Acid-Binding Ig-Like Lectin 3 3 4
  • CD33 Antigen (Gp67) 2 3
  • SIGLEC-3 3 4
  • SIGLEC3 3 4
  • Gp67 3 4
  • Sialic Acid Binding Ig-Like Lectin 3 2
  • Myeloid Cell Surface Antigen CD33 3
  • CD33 Molecule Transcript 3
  • CD33 Antigen 4
  • P67 3

External Ids for CD33 Gene

Previous GeneCards Identifiers for CD33 Gene

  • GC19P052358
  • GC19P052089
  • GC19P056404
  • GC19P056420
  • GC19P051729
  • GC19P048061

Summaries for CD33 Gene

GeneCards Summary for CD33 Gene

CD33 (CD33 Molecule) is a Protein Coding gene. Diseases associated with CD33 include Gallbladder Lymphoma and Extracutaneous Mastocytoma. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is SIGLEC6.

UniProtKB/Swiss-Prot for CD33 Gene

  • Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD33 Gene

Genomics for CD33 Gene

Regulatory Elements for CD33 Gene

Enhancers for CD33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051223 1.2 Ensembl ENCODE 10.1 +10.3 10349 3.8 PKNOX1 ARNT TCF12 ZNF766 GATA2 FOS NCOA1 SMARCA4 NBN KDM1A SIGLECL1 CD33 RPL7P51 SIGLEC14 SIGLEC5
GH19G051245 1.1 Ensembl ENCODE 6.8 +30.6 30566 1.2 HDAC1 CBX3 TAL1 BACH1 MAX CEBPG TCF12 ZNF316 NCOR1 NR2F6 ENSG00000268595 CD33 SIGLECL1
GH19G051466 1.6 FANTOM5 Ensembl ENCODE 3.8 +252.1 252091 2.7 HDGF PKNOX1 ATF1 CREB3L1 SIN3A TCF12 ZNF766 ELK1 GATA2 CBX5 SIGLEC6 ZNF175 SIGLEC5 SIGLEC14 RPL7P51 FPR3 SIGLEC12 SIGLEC8 CD33 SIGLEC7
GH19G051460 1.5 FANTOM5 Ensembl ENCODE 2.9 +245.9 245864 2.0 CREB3L1 ARNT ETS1 ZNF143 KLF13 KDM4B NCOA1 ZNF518A ZNF592 KAT8 SIGLEC5 SIGLEC14 RPL7P51 SIGLEC6 SIGLEC8 SIGLEC7 ZNF175 ZNF613 SIGLEC10 CD33
GH19G051121 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -89.4 -89402 10.3 PKNOX1 FOXA2 ATF1 ARNT YBX1 ZBTB7B TCF12 GATA2 FOS YY2 SIGLEC9 ZNF841 ZNF577 POLD1 SIGLEC18P KLK11 CTU1 C19orf81 SIGLEC10 CD33
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD33 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD33 Gene

Chromosome:
19
Start:
51,215,537 bp from pter
End:
51,243,860 bp from pter
Size:
28,324 bases
Orientation:
Plus strand

Genomic View for CD33 Gene

Genes around CD33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD33 Gene

Proteins for CD33 Gene

  • Protein details for CD33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20138-CD33_HUMAN
    Recommended name:
    Myeloid cell surface antigen CD33
    Protein Accession:
    P20138
    Secondary Accessions:
    • B4E3P8
    • C9JEN7
    • F8WAL2
    • Q8TD24

    Protein attributes for CD33 Gene

    Size:
    364 amino acids
    Molecular mass:
    39825 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.

    Alternative splice isoforms for CD33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD33 Gene

Post-translational modifications for CD33 Gene

  • Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
  • Glycosylation at Asn100, posLast=113113, posLast=160160, Asn209, and posLast=230230
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CD33

No data available for DME Specific Peptides for CD33 Gene

Domains & Families for CD33 Gene

Suggested Antigen Peptide Sequences for CD33 Gene

Graphical View of Domain Structure for InterPro Entry

P20138

UniProtKB/Swiss-Prot:

CD33_HUMAN :
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with CD33: view

Function for CD33 Gene

Molecular function for CD33 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD33-like (gp67),identified by monoclonal antibodies L4F3,My9,H153,L1B1,expressed in immature cells of the myelomonocytic lineage,sialoadhesin family,myeloid specific inhibitory receptor that may regulate FcgammaRI signal transduction,Ig superfamily
UniProtKB/Swiss-Prot Function:
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

Gene Ontology (GO) - Molecular Function for CD33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10611343
GO:0005515 protein binding IPI 10206955
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CD33: view
genes like me logo Genes that share phenotypes with CD33: view

Animal Model Products

CRISPR Products

miRNA for CD33 Gene

miRTarBase miRNAs that target CD33

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CD33

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD33 Gene

Localization for CD33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD33 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD33 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 3139766
GO:0009897 external side of plasma membrane IDA 20660734
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD33: view

Pathways & Interactions for CD33 Gene

genes like me logo Genes that share pathways with CD33: view

SIGNOR curated interactions for CD33 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,NAS --
GO:0007165 signal transduction TAS 10611343
GO:0007267 cell-cell signaling TAS 10611343
GO:0008285 negative regulation of cell proliferation TAS 10611343
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with CD33: view

Drugs & Compounds for CD33 Gene

(6) Drugs for CD33 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemtuzumab ozogamicin Approved, Investigational, Withdrawn Pharma antibody, Target 0
Mylotarg Approved May 2000 Pharma 0
LINTUZUMAB Pharma 0

(3) Additional Compounds for CD33 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD33: view

Transcripts for CD33 Gene

Unigene Clusters for CD33 Gene

CD33 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CD33

Alternative Splicing Database (ASD) splice patterns (SP) for CD33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3:

Relevant External Links for CD33 Gene

GeneLoc Exon Structure for
CD33
ECgene alternative splicing isoforms for
CD33

Expression for CD33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD33 Gene

mRNA differential expression in normal tissues according to GTEx for CD33 Gene

This gene is overexpressed in Whole Blood (x15.8) and Spleen (x7.6).

Protein differential expression in normal tissues from HIPED for CD33 Gene

This gene is overexpressed in Monocytes (22.9), Peripheral blood mononuclear cells (21.9), and Milk (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD33 Gene



Protein tissue co-expression partners for CD33 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD33 Gene:

CD33

SOURCE GeneReport for Unigene cluster for CD33 Gene:

Hs.83731

mRNA Expression by UniProt/SwissProt for CD33 Gene:

P20138-CD33_HUMAN
Tissue specificity: Monocytic/myeloid lineage cells.

Evidence on tissue expression from TISSUES for CD33 Gene

  • Blood(4.7)
  • Bone marrow(3.6)
  • Spleen(2.9)
  • Lymph node(2.5)
genes like me logo Genes that share expression patterns with CD33: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD33 Gene

Orthologs for CD33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD33 34 35
  • 98.4 (n)
dog
(Canis familiaris)
Mammalia CD33 34
  • 73.12 (n)
-- 35
  • 36 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia LOC508441 34
  • 72.79 (n)
-- 35
  • 55 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Siglech 35
  • 49 (a)
OneToMany
Cd33 35
  • 40 (a)
OneToMany
Species where no ortholog for CD33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD33 Gene

ENSEMBL:
Gene Tree for CD33 (if available)
TreeFam:
Gene Tree for CD33 (if available)

Paralogs for CD33 Gene

(9) SIMAP similar genes for CD33 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CD33 Gene

genes like me logo Genes that share paralogs with CD33: view

Variants for CD33 Gene

Sequence variations from dbSNP and Humsavar for CD33 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000041874 -- 51,233,189(+) CTGTT(C/T)CTCAG intron-variant
rs1000106922 -- 51,216,929(+) GGAAG(A/G)GCAAA intron-variant
rs1000171072 -- 51,238,057(+) TCTCA(G/T)ATGTC intron-variant
rs1000293701 -- 51,223,470(+) ACTAC(A/G)CAGAG intron-variant, upstream-variant-2KB
rs1000368114 -- 51,231,828(+) ATCAC(A/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD33 Gene

Variant ID Type Subtype PubMed ID
nsv1134806 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv476420 CNV novel sequence insertion 20440878

Variation tolerance for CD33 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD33 Gene

Human Gene Mutation Database (HGMD)
CD33
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD33 Gene

Disorders for CD33 Gene

MalaCards: The human disease database

(14) MalaCards diseases for CD33 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gallbladder lymphoma
  • lymphoma of the gallbladder
extracutaneous mastocytoma
  • mastocytoma
acute leukemia
  • stem cell leukaemia
nasu-hakola disease
  • polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
myeloid leukemia
  • leukemia myelogenous
- elite association - COSMIC cancer census association via MalaCards
Search CD33 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD33

Genetic Association Database (GAD)
CD33
Human Genome Epidemiology (HuGE) Navigator
CD33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD33
genes like me logo Genes that share disorders with CD33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD33 Gene

Publications for CD33 Gene

  1. A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. (PMID: 16380601) Hernandez-Caselles T. … Garcia-Penarrubia P. (J. Leukoc. Biol. 2006) 3 4 22 64
  2. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. (PMID: 10206955) Taylor V.C. … Freeman S.D. (J. Biol. Chem. 1999) 3 4 22 64
  3. Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. (PMID: 3139766) Simmons D. … Seed B. (J. Immunol. 1988) 2 3 4 64
  4. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. (PMID: 21460841) Naj A.C. … Schellenberg G.D. (Nat. Genet. 2011) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for CD33 Gene

Sources for CD33 Gene

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