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CD33 Gene

protein-coding GIFtS: 66

GC19P056420

CD33 molecule
(Previous name: CD33 antigen (gp67) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ00391 ^¹, ²
SIGLEC-3 ^¹, ²
SIGLEC3 ^¹, ², ³
Siglec-3 ^³
gp67 ^³
p67 ^¹, ²

Descriptions
CD33 antigen ^², ³
CD33 antigen (gp67) ^¹, ²
CD33 molecule ^²
Sialic acid-binding Ig-like lectin 3 ^³

External Ids
HGNC: 1659¹
Entrez Gene: 945²
UniProtKB: P20138³
Ensembl: ENSG00000105383⁷

Search outside databases for aliases for CD33 gene

Previous GC identifers: GC19P052358 GC19P052089 GC19P056404

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CD33_HUMAN, P20138

Function: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid

dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid

recognition site may be masked by cis interactions with sialic acids on the same cell surface. In

the immune response, may act as an inhibitory receptor upon ligand induced tyrosine

phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal

transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid

leukemia (in vitro)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CD33 gene

Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3

CD33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P056420: (about GC identifiers)

Start:	56,420,147 bp from pter
End:	56,435,086 bp from pter
Size:	14,940 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CD33_HUMAN, P20138 (See protein sequence)

Recommended Name: Myeloid cell surface antigen CD33 precursor

Size: 364 amino acids; 39825 Da

Subunit: Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation

Subcellular location: Cell membrane; Single-pass type I membrane protein

Secondary accessions: Q8TD24

Post-translational modifications:

Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358

is involved in binding to PTPN6¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001076087.1 NP_001763.3

ENSEMBL proteins:

ENSP00000262262

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for CD33 (Siglec-3/CD33)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD7 + CD13 + CD33, CD33, CD7 + CD33)
	Human Recombinant Proteins from Abnova (CD33)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	3139766
GO:0005887	integral to plasma membrane	TAS	3139766

About this table

Antibodies for CD33:

	Invitrogen Antibodies for CD33
	Millipore Mono- and Polyclonal Antibodies for the study of CD33
	Sigma-Aldrich Antibodies for CD33
	R&D Systems Antibodies for CD33 (Siglec-3/CD33)
	Antibodies from Abcam (CD7 + CD13 + CD33, CD33, CD7 + CD33), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CD33)
	Novus Biologicals Antibodies for CD33

Assays for CD33:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P20138

ProtoNet protein and cluster: P20138

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: CD33_HUMAN, P20138

Domain: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor

tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses.

The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases

Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin)

family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD33)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD33)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001082618

Applied Biosystems Silencer® siRNAs for CD33

Sigma-Aldrich siRNA and siRNA Panels for CD33

Sigma-Aldrich shRNA for CD33

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CD33
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001082618
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001082618
untagged cDNA clones in CMV expression vector (see all 2): NM_001082618

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001772

UniProtKB/Swiss-Prot: CD33_HUMAN, P20138

Function: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid

dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid

recognition site may be masked by cis interactions with sialic acids on the same cell surface. In

the immune response, may act as an inhibitory receptor upon ligand induced tyrosine

phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal

transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid

leukemia (in vitro)

Genatlas biochemistry entry for CD33:

cell differentiation antigen CD33-like (gp67),identified by monoclonal antibodies

L4F3,My9,H153,L1B1,expressed in immature cells of the myelomonocytic lineage,sialoadhesin

family,myeloid specific inhibitory receptor that may regulate FcgammaRI signal transduction,Ig

superfamily

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cd33):

hematopoietic system

homeostasis/metabolism

immune system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	10611343
GO:0005515	protein binding	IEA	--
GO:0005529	sugar binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CD33

4 Interacting proteins for CD33 (ENSP00000262262³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MUC2	ENSP00000351956³	STRING (score=.871)
PTPN6	ENSP00000326010³	STRING (score=.741)
PTPN11	ENSP00000340944³	STRING (score=.726)
--	ENSP00000350562³	STRING (score=.704)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	NAS	10611343
GO:0007165	signal transduction	TAS	10611343
GO:0007267	cell-cell signaling	TAS	10611343
GO:0008285	negative regulation of cell proliferation	TAS	10611343

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CD33
5 Novoseek chemical compound relationships for CD33 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hum 195	87.19	2	10690513 (1), 12813444 (1)
nitroblue tetrazolium	33.74	4	9772451 (1), 15625759 (1)
tyrosine	22.62	12	10206955 (5), 10887109 (2), 18769895 (1), 9731071 (1) (see all 5)
thymidine	10.00	1	10942240 (1)
calcium	0.00	2	15313016 (1), 10887109 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CD33)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CD33)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001082618

Sigma-Aldrich siRNA and siRNA Panels for CD33

Sigma-Aldrich shRNA for CD33

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001082618 NM_001772

REFSEQ mRNAs for CD33 gene (2 alternative transcripts):

NM_001082618.1 NM_001772.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001082618 NM_001772

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001082618
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001082618
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001082618

Additional cDNA sequence:

AK293934.1 AK304810.1 AK309558.1 AY162464.1 BC028152.1 M23197.1

4 DOTS entries:

DT.409921 DT.95368780 DT.101980036 DT.95112136

24/37 AceView cDNA sequences (see all 37 ):

BC028152 BM906276 BX399458 AI831598 AK090470 CR592075 NM_001772 AI344474

AY162464 BQ006987 AI309276 CA425585 AA004657 D20190 AA772086 BI770340

BG179257 CA748646 AI142518 BI911521 BU933504 BI910568 AA701529 M23197

highest scoring ESTs for CD33:

M23197 AA004657 AA701529 AA772086 AA873590 AI142518 AI309276 AI344474 AI831598 AW007749

Unigene Cluster for CD33:

CD33 molecule

Hs.83731 [show with all ESTs]

Unigene Representative Sequence: BC028152

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CD33

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b
SP1:
SP2:					-
SP3:

About this scheme

ECgene alternative splicing isoforms for CD33

1 Ensembl transcript including schematic representation:

ENST00000262262

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CD33 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CD33

¹ / ² / ³

3 probe-sets matching CD33 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36802_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M23197	1.00	1.00	1.00	1
206120_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001772	0.60	1.00	0.82	1
206120_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CD33 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAAACAAAA

SOURCE GeneReport for Unigene cluster: Hs.83731
Expression variation in blood from EXPOLDB for CD33
UniProtKB/Swiss-Prot: CD33_HUMAN, P20138
Tissue specificity: Monocytic/myeloid lineage cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CD33 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	CD33¹	--	CD33 molecule	98.44(n) 96.15(a)	456242 XM_512850.2 XP_512850.2
cow (Bos taurus)	CD33¹	--	CD33 molecule	72.77(n) 63.37(a)	508441 XM_585217.2 XP_585217.2
mouse (Mus musculus)	Cd33⁵	7 (23.00 cM)	CD33 antigen	--	S71403

About this table Species with no ortholog for CD33

ENSEMBL Gene Tree for CD33

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CD33 gene

SIGLECP3² SIGLEC6² SIGLEC12² SIGLEC8² SIGLEC7² SIGLEC9²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/99 NCBI SNPs in CD33 are shown (see all 99 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 58)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1710398^1,2	A,C,F,H,O	56418723(-)	`TTGGTG/TCAGTG`	2	--	ng5¹		11		EA NA EU	662
	rs1697553^1,2	A,C,F,H	56419134(+)	`gacagA/Gtttta`	2	--	ng5¹ tfbs³		4		EU EA WA	418
	rs3826656^1,2	A,C,F,H	56418425(+)	`TATTAA/GTAAGG`	2	--	ng5¹		8		EU EA WA NA	634
--	rs2455069^1,2	A,C,F,H	56420453(+)	`TATCCA/GGGGAC`	2	R/G	mis¹ int¹		16		NA EU EA WA	1474
	rs1803254^1,2	A,C,F,H	56434956(+)	`gctaaG/Ctgtat`	2	--	ut3¹		11		EU EA WA NA	980
	rs3865444^1,2	A,C,F,H	56419774(-)	`TCCATG/TGGGTG`	2	--	ng5¹ tfbs³		16		EU EA WA NA	1464
	rs2271652^1,2	C,F,H	56430699(-)	`GCCCAC/ATGCTG`	2	L/V	mis¹ ese³		5		EA EU WA	1892
	rs11882250^1,2	C,F,H	56421406(+)	`GTATCT/CTTCCA`	2	L/F	mis¹		9		EU EA WA NA	916
	rs10164274^1,2	A,F,H	56435278(+)	`TCATCT/CCACCT`	2	--	ng3¹		4		EU EA WA	414
--	rs1399837^1,2	A,C	56418167(-)	`gggatC/Gacagg`	2	--	ng5¹ tfbs³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CD33 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 159590

10/13 Novoseek disease relationships for CD33 gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia	64.31	4	8616860 (1), 10690513 (1), 7869759 (1), 11904967 (1)
leukemia promyelocytic acute	61.70	1	17076651 (1)
leukemia	58.93	6	11328295 (1), 18668307 (1), 7559258 (1), 11986941 (1) (see all 5)
acute leukemia	57.06	1	11328295 (1)
t-all	50.54	1	10891465 (1)
leukemia nonlymphocytic acute	45.06	1	1574028 (1)
myeloid leukemia chronic	41.89	1	12375643 (1)
myelodysplastic syndromes	35.82	1	12375643 (1)
lymphoma	5.84	1	11328295 (1)
myeloma	4.68	1	8148313 (1)

About this table

Human Genome Epidemiology Navigator: CD33 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/141 PubMed articles for CD33 gene (see all 141 ):

Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. (PubMed id 3139766)^{2, 3, 4} Simmons D. and Seed B. (1988)
The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. (PubMed id 10206955)^{1, 3, 4} Taylor V.C....Freeman S.D. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. (PubMed id 11943481)^{3, 4} Yousef G.M.... Diamandis E.P. (2002)
Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells. (PubMed id 11320212)^{3, 4} Vitale C.... Mingari M.C. (2001)
The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. (PubMed id 10556798)^{3, 4} Ulyanova T.... Thomas M.L. (1999)
Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. (PubMed id 9465907)^{2, 3} Takei Y....Nakamura Y. (1997)
Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. (PubMed id 7718872)^{3, 4} Freeman S.D.... Crocker P.R. (1995)
A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. (PubMed id 16380601)^{1, 3} Hernandez-Caselles T....Garcia-Penarrubia P. (2006)
Phosphorylated ITIMs enable ubiquitylation of an inhibitory cell surface receptor. (PubMed id 18062779)^{1, 3} Walter R.B....Cooper J.A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 945	HGNC: 1659	AceView: CD33	Ensembl:ENSG00000105383	euGenes: HUgn945
ECgene: CD33	H-InvDB: CD33

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CD33	Genetics and Cytogenetics in Oncology and Haematology
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_270

Licensable Technologies for CD33
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for CD33 gene:

Weizmann Institute:

Novel treatment for improving bone-marrow transplantation success

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CD33:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CD33-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CD33		Antibodies for CD33
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CD33		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CD33)
	Antibodies (CD33)
	Chimera RNAi (CD33)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CD7 + CD13 + CD33, CD33, CD7 + CD33)
	Antibodies (CD7 + CD13 + CD33, CD33, CD7 + CD33)

Search OriGene for CD33

Search Tocris compounds for CD33

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CD33

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CD33 Gene at Home site.
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CD33 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CD33

Summaries
for CD33

Genomic Location
for CD33

Proteins
for CD33

Protein Domains/
Families
for CD33

Gene Function
for CD33

Pathways & Interactions
for CD33

Drugs & Compounds
for CD33

Transcripts
for CD33

Expression
for CD33

Orthologs
for CD33

Paralogs
for CD33

SNPs/Variants
for CD33

Disorders & Mutations
for CD33

Medical News
for CD33

Publications
for CD33

Search for CD33

Genome Databases showing CD33

Other Databases showing CD33

Specialized Databases showing CD33

Licensable Technologies
for CD33

Services
for CD33

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CD33 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CD33

Summariesfor CD33

Genomic Locationfor CD33

Proteinsfor CD33

Protein Domains/Familiesfor CD33

Gene Functionfor CD33

Pathways & Interactionsfor CD33

Drugs & Compoundsfor CD33

Transcriptsfor CD33

Expression for CD33

Orthologsfor CD33

Paralogsfor CD33

SNPs/Variantsfor CD33

Disorders & Mutationsfor CD33

Medical Newsfor CD33

Publicationsfor CD33

Search for CD33

Genome Databases showing CD33

Other Databases showing CD33

Specialized Databases showing CD33

Licensable Technologiesfor CD33

Servicesfor CD33

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CD33

Summaries
for CD33

Genomic Location
for CD33

Proteins
for CD33

Protein Domains/
Families
for CD33

Gene Function
for CD33

Pathways & Interactions
for CD33

Drugs & Compounds
for CD33

Transcripts
for CD33

Expression
for CD33

Orthologs
for CD33

Paralogs
for CD33

SNPs/Variants
for CD33

Disorders & Mutations
for CD33

Medical News
for CD33

Publications
for CD33

Licensable Technologies
for CD33

Services
for CD33