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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CD33 Gene

protein-coding GIFtS: 65
GCID: GC19P051729

CD33 molecule

(Previous name: CD33 antigen (gp67) )

Explore 21 diseases affiliated with
CD33 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CD33 Molecule¹ ²		Gp67¹
SIGLEC3¹ ² ³		FLJ00391¹
SIGLEC-3¹ ²		Myeloid Cell Surface Antigen CD33²
CD33 Antigen (Gp67)¹ ²		Sialic Acid Binding Ig-Like Lectin 3²
P67¹		Siglec-3³
Sialic Acid-Binding Ig-Like Lectin 3² ³		CD33 Antigen³

External Ids:	HGNC: 1659¹	Entrez Gene: 945²	Ensembl: ENSG00000105383⁷	OMIM: 159590⁵	UniProtKB: P20138³

Export aliases for CD33 gene to outside databases

Previous GC identifers: GC19P052358 GC19P052089 GC19P056404 GC19P056420 GC19P048061

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CD33_HUMAN, P20138

Function: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to

cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis

interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor

upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that

block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid

leukemia (in vitro)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CD33 gene promoter:
STAT1 RelA NF-kappaB C/EBPalpha Arnt GATA-1 AREB6 PPAR-gamma1 PPAR-gamma2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD33 promoter sequence

Search SABiosciences Chromatin IP Primers for CD33

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD33

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.3

CD33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD33 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P051729: view genomic region (about GC identifiers)

Start:	51,728,320 bp from pter	End:	51,743,274 bp from pter
Size:	14,955 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CD33_HUMAN, P20138 (See protein sequence)

Recommended Name: Myeloid cell surface antigen CD33 precursor

Size: 364 amino acids; 39825 Da

Subunit: Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation

Subcellular location: Cell membrane; Single-pass type I membrane protein

Secondary accessions: B4E3P8 C9JEN7 F8WAL2 Q8TD24

Alternative splicing: 3 isoforms: P20138-1 P20138-2 P20138-3 (Mostly detected on NKL and myeloid cell lines but poorly expressed on B cell lines and T lymphocytes)

Explore the universe of human proteins at neXtProt for CD33: NX_P20138

Post-translational modifications:

Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in

binding to PTPN6¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20138

CD33 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001076087.1 NP_001171079.1 NP_001763.3

ENSEMBL proteins:

ENSP00000262262 ENSP00000410126 ENSP00000375673 ENSP00000403331

Human Recombinant Protein Products for CD33:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD33 (Siglec-3/CD33)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CD33 OriGene Protein Over-expression Lysate (see all 3): CD33 OriGene Custom Protein Services for CD33
	GenScript Custom Purified and Recombinant Proteins Services for CD33
	Novus Biologicals CD33 Proteins Novus Biologicals CD33 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD33

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	3139766
GO:0005887	integral to plasma membrane	TAS	3139766
GO:0009897	external side of plasma membrane	IDA	--

CD33 for ontologies About GeneDecksing

CD33 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CD33
	R&D Systems Antibodies for CD33 (Siglec-3/CD33)
	OriGene Antibodies (see all 9): CD33 OriGene Custom Antibody Services for CD33
	GenScript Custom Superior Antibodies Services for CD33
	Novus Biologicals CD33 Antibodies
	Abcam antibodies for CD33
	Uscn Antibodies for CD33
	ThermoFisher Antibody for CD33

Assay Products for CD33:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CD33 (Siglec-3/CD33)
	GenScript Custom Assay Services for CD33
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD33

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CD33 for domains About GeneDecksing

5 InterPro domains/families:

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013151 Immunoglobulin

Graphical View of Domain Structure for InterPro Entry P20138

ProtoNet protein and cluster: P20138

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: CD33_HUMAN, P20138

Domain: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor

motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the

SH2 domain of several SH2-containing phosphatases

Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CD33_HUMAN, P20138

Function: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to

cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis

interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor

upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that

block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid

leukemia (in vitro)

Genatlas biochemistry entry for CD33:

cell differentiation antigen CD33-like (gp67),identified by monoclonal antibodies L4F3,My9,H153,L1B1,expressed in

immature cells of the myelomonocytic lineage,sialoadhesin family,myeloid specific inhibitory receptor that may

regulate FcgammaRI signal transduction,Ig superfamily

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	10611343
GO:0030246	carbohydrate binding	--	--

CD33 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CD33:

Upregulation of Wnt/beta-caten

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cd33):

hematopoietic system

homeostasis/metabolism

immune system

CD33 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cd33^tm1Ajv for CD33

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CD33

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD33 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD33
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CD33:
		hsa-miR-518a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CD33 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD33 (see all 4) OriGene shRNA RFP: CD33 OriGene siRNA: CD33
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD33
		Sirion Biotech Custom design and validation of potent shRNA sequences against CD33

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CD33
			Sirion Biotech Customized adenovirus for overexpression of CD33 Sirion Biotech Customized adenovirus for potent knockdown of CD33

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD33 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD33 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CD33 (NM_001772)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD33
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD33

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD33
		Search LifeMap BioReagents cell lines for CD33
		Sirion Biotech Customized stable knockdown cell line services for CD33 Sirion Biotech Customized inducible knockdown cell line services for CD33 Sirion Biotech Customized stable overexpressing cell line services for CD33 Sirion Biotech Customized inducible overexpressing cell line services for CD33

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD33

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Hematopoietic cell lineage

Hematopoietic cell lineage

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for CD33):

Hematopoietic cell lineage

CD33 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CD33

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/14 Interacting proteins for CD33 (P20138^{2, 3} ENSP00000262262⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN11	Q06124²^,³, ENSP00000340944⁴	MINT-8033919 MINT-8033893 I2D: score=5 STRING: ENSP00000340944
PTPN6	P29350²^,³, ENSP00000391592⁴	MINT-8033951 MINT-8031385 MINT-8033908 MINT-8033935 MINT-8033882 I2D: score=5 STRING: ENSP00000391592
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
CBL	P22681³, ENSP00000264033⁴	I2D: score=2 STRING: ENSP00000264033
SRC	P12931³, ENSP00000350941⁴	I2D: score=2 STRING: ENSP00000350941

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0007165	signal transduction	TAS	10611343
GO:0007267	cell-cell signaling	TAS	10611343
GO:0008285	negative regulation of cell proliferation	TAS	10611343

CD33 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CD33 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CD33

1 DrugBank Compound for CD33 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Gemtuzumab ozogamicin	anti-CD33 (see all 2)	220578-59-6	target	antibody	11410481 11432892 10942240 11752352 11342449 11249747 20564405

7 Novoseek chemical compound relationships for CD33 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gemtuzumab ozogamicin	95.2	25	11342449 (2), 17076651 (1), 16413391 (1), 20428776 (1) (see all 14)
calicheamicin	94.2	5	11410481 (1), 15658471 (1), 20139663 (1), 12939719 (1) (see all 5)
hum 195	86.5	2	10690513 (1), 12813444 (1)
nitroblue tetrazolium	33	4	9772451 (1), 15625759 (1)
tyrosine	21.3	12	10206955 (5), 10887109 (2), 18769895 (1), 9731071 (1) (see all 5)
thymidine	9.19	1	10942240 (1)
calcium	0	2	15313016 (1), 10887109 (1)

Search CenterWatch for drugs/clinical trials and news about CD33

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CD33 gene (3 alternative transcripts):

NM_001082618.1 NM_001177608.1 NM_001772.3

Unigene Cluster for CD33:

CD33 molecule

Hs.83731 [show with all ESTs]

Unigene Representative Sequence: BC028152

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262262(uc002pwa.2) ENST00000421133(uc010eot.1) ENST00000391796

ENST00000436584(uc010eos.1 uc010eou.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD33 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD33
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CD33:
		hsa-miR-518a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CD33 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD33 (see all 4) OriGene shRNA RFP: CD33 OriGene siRNA: CD33
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD33
		Sirion Biotech Custom design and validation of potent shRNA sequences against CD33

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD33 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD33 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CD33 (NM_001772)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD33
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD33

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD33 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CD33
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD33
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD33

Additional cDNA sequence:

AK293934.1 AK304810.1 AK309558.1 AY162464.1 BC028152.1 M23197.1

4 DOTS entries:

DT.409921 DT.95368780 DT.101980036 DT.95112136

24/37 AceView cDNA sequences (see all 37):

AY162464 BX399458 BM906276 AI831598 NM_001772 AK090470 BC028152 CR592075

BQ006987 AI344474 AI309276 CA416601 BI770340 BU619600 BI911521 AA873590

AA701529 M23197 AA004657 AW007749 CA426969 D20190 AW136016 BU933504

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CD33 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b
SP1:
SP2:					-
SP3:

ECgene alternative splicing isoforms for CD33

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CD33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAACAAAA

About this image

CD33 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Peripheral Blood

Common Myeloid Progenitor Cells

Selective marker (cell-identifying gene)

Blood

Peripheral Blood

Granulocyte-Monocyte Progenitor Cells

Blood

Peripheral Blood

Monocytes

Blood

Peripheral Blood

Myeloid Dendritic Cells

Blood

Blood

Hematopoietic Stem Cells

Blood

Peripheral Blood

Erythroid Progenitor Cells

Blood

Peripheral Blood

Megakaryocyte-Erythroid Precursor Cells

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Expanded PAX7 cells (Generation of skelet...)

See CD33 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CD33

SOURCE GeneReport for Unigene cluster: Hs.83731

UniProtKB/Swiss-Prot: CD33_HUMAN, P20138

Tissue specificity: Monocytic/myeloid lineage cells

SABiosciences Custom PCR Arrays for CD33

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD33 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CD33
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD33
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD33

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD33

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CD33 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	33(a) 25(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343281.1(1713612-1717084) GL343281.1(1573835-1580218)
zebrafish (Danio rerio)	Actinopterygii	CR548631.1⁶ si:dkeyp-28d2.4⁶ (see all 9)	si:dkeyp-28d2.4 (see all 9)	16(a) 14(a) (see all 9)	many ↔ many many ↔ many (see all 9)	4(948645-951913) 24(12816474-12819193)

ENSEMBL Gene Tree for CD33 (if available)
TreeFam Gene Tree for CD33 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CD33 gene

SIGLEC17P² SIGLEC8² SIGLEC5² SIGLEC16² SIGLEC11² SIGLEC6² SIGLEC14² SIGLEC12²

MAG² SIGLEC10² SIGLEC7² SIGLEC9²

10 SIMAP similar genes for CD33 using alignment to 3 protein entries: CD33_HUMAN (see all proteins):

SIGLEC14 SIGLEC5 SIGLEC11 SIGLEC10 SIGLEC16 SIGLEC6

SIGLEC8 SIGLEC9 SIGLEC12 SIGLEC7

CD33 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for CD33
PGOHUM00000234379 PGOHUM00000234383 PGOHUM00000234742

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1399837^1,2	C,F,A	--	51726355(-)	`gggatC/Gacagg`	3	--	us2k¹ tfbs³		8		NA WA CSA EA	367
rs117368363^1,2	F	--	51726367(+)	`GCTACT/CAGAGA`	3	--	us2k¹		1		NA	120
rs78451359^1,2		--	51726380(+)	`ATGACG/ATGGGA`	3	--	us2k¹		1		WA	118
rs114908382^1,2		--	51726436(+)	`AGGCCG/AGTGCA`	3	--	us2k¹		1		WA	118
rs115466481^1,2		--	51726513(+)	`TATTAC/TGTGCC`	3	--	us2k¹		1		WA	118
rs146731068^1,2		--	51726524(+)	`ACATGC/TTAAAT`	3	--	us2k¹		0	--	--	--	--
rs3826656^1,2	C,F,A,H	--	51726613(+)	`TATTAA/GTAAGG`	3	--	us2k¹		32		NS EA NA WA CSA	2575
rs192632937^1,2		--	51726705(+)	`TCAACC/GGTTTG`	3	--	us2k¹		0	--	--	--	--
rs1710398^1,2	C,F,O,A,H	--	51726911(-)	`TTGGTT/GCAGTG`	3	--	us2k¹		29		EA NA NS WA CSA	2701
rs139126986^1,2		--	51726918(+)	`CCAAAC/TGGCAG`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CD33 (51728320 - 51743274 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CD33: --
Human Gene Mutation Database (HGMD): CD33

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD33

DNA2.0 Custom Variant and Variant Library Synthesis for CD33

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CD33 for disorders           About GeneDecksing

OMIM gene information: 159590    OMIM disorders: --

20/21 diseases for CD33 (see all 21):    About MalaCards

anaplastic large cell lymphoma myeloid leukemia lymphoblastic leukemia acute promyelocytic leukemia

giant cell tumor leukemia myelodysplastic syndrome acute lymphoblastic leukemia

chronic lymphocytic leukemia acute myeloid leukemia lymphocytic leukemia acute leukemia

alzheimer's disease hepatitis b noma myeloma

hematopoiesis t-cell leukemia lung cancer hepatitis

5 diseases from the University of Copenhagen DISEASES database for CD33:

Leukemia Myeloid sarcoma Lymphoma Myeloma

Anemia

10/14 Novoseek disease relationships for CD33 gene (see all 14) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia promyelocytic acute	65.2	2	17076651 (1), 20032408 (1)
myeloid leukemia	63.4	4	8616860 (1), 10690513 (1), 7869759 (1), 11904967 (1)
leukemia	59.4	7	11328295 (1), 18668307 (1), 20032408 (1), 7559258 (1) (see all 6)
acute leukemia	56	1	11328295 (1)
t-all	49.1	1	10891465 (1)
lymphoblastic leukemia acute	49	2	20032408 (1), 19725224 (1)
leukemia nonlymphocytic acute	44.6	1	1574028 (1)
myeloid leukemia chronic	40.5	1	12375643 (1)
myelodysplastic syndromes	34.3	1	12375643 (1)
lymphoma	4.36	1	11328295 (1)

Human Genome Epidemiology (HuGE) Navigator: CD33 (6 documents)

Export disorders for CD33 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CD33 gene, integrated from 9 sources (see all 170):
(articles sorted by number of sources associating them with CD33)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. (PubMed id 3139766)^{1, 2, 3} Simmons D. and Seed B. (1988)
The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. (PubMed id 10206955)^{1, 2, 9} Taylor V.C....Freeman S.D. (1999)
A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. (PubMed id 16380601)^{1, 2, 9} Hernandez-Caselles T....Garcia-Penarrubia P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. (PubMed id 11943481)^{1, 2} Yousef G.M.... Diamandis E.P. (2002)
Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells. (PubMed id 11320212)^{1, 2} Vitale C.... Mingari M.C. (2001)
The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. (PubMed id 10556798)^{1, 2} Ulyanova T.... Thomas M.L. (1999)
Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. (PubMed id 9465907)^{1, 3} Takei Y.... Nakamura Y. (1997)
Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. (PubMed id 7718872)^{1, 2} Freeman S.D.... Crocker P.R. (1995)
Phosphorylated ITIMs enable ubiquitylation of an inhibitory cell surface receptor. (PubMed id 18062779)^{1, 9} Walter R.B....Cooper J.A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 945	HGNC: 1659	AceView: CD33	Ensembl:ENSG00000105383	euGenes: HUgn945
ECgene: CD33	Kegg: 945	H-InvDB: CD33

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CD33	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CD33	Genetics and Cytogenetics in Oncology and Haematology
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_270

Intellectual Property for CD33 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CD33 gene:
Search GeneIP for patents involving CD33

Licensable Technologies for CD33 gene:

Weizmann Institute:

Novel treatment for improving bone-marrow transplantation success

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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