Aliases for CD33 Gene
External Ids for CD33 Gene
Previous GeneCards Identifiers for CD33 Gene
GeneCards Summary for CD33 Gene
CD33 (CD33 Molecule) is a Protein Coding gene. Diseases associated with CD33 include cd4+/cd56+ hematodermic neoplasm and myeloid sarcoma. Among its related pathways are Hematopoietic cell lineage. GO annotations related to this gene include receptor activity. An important paralog of this gene is SIGLEC5.
UniProtKB/Swiss-Prot for CD33 Gene
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).