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CD33 Gene

protein-coding   GIFtS: 67
GCID: GC19P051729

CD33 Molecule

(Previous name: CD33 antigen (gp67))
  See CD33-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CD33 Molecule1 2     SIGLEC-32
CD33 Antigen (Gp67)1 2     Myeloid Cell Surface Antigen CD332
Sialic Acid Binding Ig-Like Lectin 31 2     p672
Sialic Acid-Binding Ig-Like Lectin 32 3     Siglec-33
SIGLEC32 3     CD33 Antigen3
gp672 3     

External Ids:    HGNC: 16591   Entrez Gene: 9452   Ensembl: ENSG000001053837   OMIM: 1595905   UniProtKB: P201383   
ORGUL members:         

Export aliases for CD33 gene to outside databases

Previous GC identifers: GC19P052358 GC19P052089 GC19P056404 GC19P056420 GC19P048061


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CD33 Gene:
CD33 (CD33 molecule) is a protein-coding gene. Diseases associated with CD33 include cd4+/cd56+ hematodermic neoplasm, and myeloid sarcoma. GO annotations related to this gene include receptor activity. An important paralog of this gene is SIGLEC8.

UniProtKB/Swiss-Prot: CD33_HUMAN, P20138
Function: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding
to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by
cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory
receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2
domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in
acute myeloid leukemia (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD33 gene promoter:
         STAT1   RelA   NF-kappaB   C/EBPalpha   Arnt   GATA-1   AREB6   PPAR-gamma1   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CD33 promoter sequence
   Search Chromatin IP Primers for CD33

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.3

CD33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD33 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051729:  view genomic region     (about GC identifiers)

Start:
51,728,320 bp from pter      End:
51,747,115 bp from pter
Size:
18,796 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD33_HUMAN, P20138 (See protein sequence)
Recommended Name: Myeloid cell surface antigen CD33 precursor  
Size: 364 amino acids; 39825 Da
Subunit: Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation
Secondary accessions: B4E3P8 C9JEN7 F8WAL2 Q8TD24
Alternative splicing: 3 isoforms:  P20138-1   P20138-2   P20138-3   (Mostly detected on NKL and myeloid cell lines but poorly expressed on B cell lines and T lymphocytes)

Explore the universe of human proteins at neXtProt for CD33: NX_P20138

Explore proteomics data for CD33 at MOPED

Post-translational modifications: 

  • Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in
    binding to PTPN61
  • Glycosylation2 at Asn100, Asn113, Asn160, Asn209, Asn230
  • Modification sites at PhosphoSitePlus

  • See CD33 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001076087.1  NP_001171079.1  NP_001763.3  

    ENSEMBL proteins: 
     ENSP00000403331   ENSP00000410126   ENSP00000375673   ENSP00000262262  

    CD33 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CD33 (Siglec-3/CD33)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CD33
    OriGene Protein Over-expression Lysate for CD33
    OriGene MassSpec for CD33
    OriGene Custom Protein Services for CD33
    GenScript Custom Purified and Recombinant Proteins Services for CD33
    Novus Biologicals CD33 Proteins
    Novus Biologicals CD33 Lysates
    Sino Biological Recombinant Protein for CD33
    Sino Biological Cell Lysate for CD33
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CD33 

    CD33 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CD33
    R&D Systems Antibodies for CD33 (Siglec-3/CD33)
    OriGene Antibodies for CD33
    OriGene Custom Antibody Services for CD33
    Novus Biologicals CD33 Antibodies
    Abcam antibodies for CD33
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CD33
    LSBio Antibodies in human, mouse, rat for CD33

    CD33 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CD33
    R&D Systems Proteome Profiler Antibody Arrays for CD33 (Siglec-3/CD33)
    GenScript Custom Assay Services for CD33
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CD33 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIGLEC: Sialic acid binding Ig-like lectins
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry P20138

    ProtoNet protein and cluster: P20138

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CD33_HUMAN, P20138
    Domain: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif
    can bind the SH2 domain of several SH2-containing phosphatases
    Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CD33           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD33_HUMAN, P20138
    Function: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding
    to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by
    cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory
    receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2
    domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in
    acute myeloid leukemia (in vitro)

         Genatlas biochemistry entry for CD33:
    cell differentiation antigen CD33-like (gp67),identified by monoclonal antibodies L4F3,My9,H153,L1B1,expressed in
    immature cells of the myelomonocytic lineage,sialoadhesin family,myeloid specific inhibitory receptor that may
    regulate FcgammaRI signal transduction,Ig superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10611343
    GO:0005515protein binding IPI10206955
         
    Find genes that share ontologies with CD33           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CD33:
     Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd33):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with CD33           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cd33tm1Ajv for CD33

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CD33
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CD33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD33
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CD33

    miRNA
    Products:
        
    miRTarBase miRNAs that target CD33:
    hsa-mir-335-5p (MIRT019168)

    Block miRNA regulation of human, mouse, rat CD33 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CD33:
    hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD33 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CD33
    Predesigned siRNA for gene silencing in human, mouse, rat CD33

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CD33

    Clone
    Products:
         
    OriGene clones in human, mouse for CD33 (see all 17)
    OriGene ORF clones in mouse, rat for CD33
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CD33 (NM_001772)
    Sino Biological Human cDNA Clone for CD33
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD33

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CD33
    Browse ESI BIO Cell Lines and PureStem Progenitors for CD33 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD33


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD33_HUMAN, P20138: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS3139766
    GO:0005887integral component of plasma membrane TAS3139766
    GO:0009897external side of plasma membrane IDA--

    Find genes that share ontologies with CD33           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CD33 About    
    See pathways by source

    SuperPathContained pathways About
    1Hematopoietic cell lineage
    Hematopoietic cell lineage


    Find genes that share SuperPaths with CD33           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for CD33):
        Hematopoietic cell lineage

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD33
    Interactions:

        GeneGlobe Interaction Network for CD33

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CD33 (P201381, 2, 3 ENSP000002622624) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293501, 2, 3, ENSP000003915924EBI-3906571,EBI-78260 MINT-8033951 MINT-8031385 MINT-8033908 MINT-8033935 MINT-8033882 I2D: score=5 STRING: ENSP00000391592
    PTPN11Q061241, 2, 3, ENSP000003409444EBI-3906571,EBI-297779 MINT-8033919 MINT-8033893 I2D: score=5 STRING: ENSP00000340944
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CBLP226813, ENSP000002640334I2D: score=2 STRING: ENSP00000264033
    SRCP129313, ENSP000003509414I2D: score=2 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS10611343
    GO:0007267cell-cell signaling TAS10611343
    GO:0008285negative regulation of cell proliferation TAS10611343

    Find genes that share ontologies with CD33           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD33

    1 DrugBank Compound for CD33    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Gemtuzumab ozogamicinanti-CD33 (see all 2)220578-59-6targetantibody11410481 11432892 10942240 11752352 11342449 11249747 20564405

    7 Novoseek inferred chemical compound relationships for CD33 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gemtuzumab ozogamicin 95.2 25 11342449 (2), 17076651 (1), 16413391 (1), 20428776 (1) (see all 14)
    calicheamicin 94.2 5 11410481 (1), 15658471 (1), 20139663 (1), 12939719 (1) (see all 5)
    hum 195 86.5 2 10690513 (1), 12813444 (1)
    nitroblue tetrazolium 33 4 9772451 (1), 15625759 (1)
    tyrosine 21.3 12 10206955 (5), 10887109 (2), 18769895 (1), 9731071 (1) (see all 5)
    thymidine 9.19 1 10942240 (1)
    calcium 0 2 15313016 (1), 10887109 (1)



    Find genes that share compounds with CD33           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD33 gene (3 alternative transcripts): 
    NM_001082618.1  NM_001177608.1  NM_001772.3  

    Unigene Cluster for CD33:

    CD33 molecule
    Hs.83731  [show with all ESTs]
    Unigene Representative Sequence: BC028152
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436584(uc010eos.1 uc010eou.1) ENST00000421133(uc010eot.1)
    ENST00000391796 ENST00000262262(uc002pwa.2) ENST00000601785 ENST00000598473
    ENST00000600557
    miRNA
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    Block miRNA regulation of human, mouse, rat CD33 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CD33:
    hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCD33 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): CD33 (NM_001772)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD33
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD33
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CD33
      QuantiTect SYBR Green Assays in human, mouse, rat CD33
      QuantiFast Probe-based Assays in human, mouse, rat CD33

    Additional mRNA sequence: 

    AK293934.1 AK304810.1 AK309558.1 AY162464.1 BC028152.1 M23197.1 

    4 DOTS entries:

    DT.409921  DT.95368780  DT.101980036  DT.95112136 

    Selected AceView cDNA sequences (see all 37):

    BQ006987 NM_001772 BM906276 AY162464 AI831598 AK090470 CR592075 BX399458 
    BC028152 AI344474 AW136016 CA416601 BI910568 AI142518 CA426969 AW007749 
    BI770340 AA004657 D20190 M23197 AA772086 AI309276 CA748646 AA701529 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CD33    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:              -                                       
    SP3:                                                      


    ECgene alternative splicing isoforms for CD33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAACAAAA
    CD33 Expression
    About this image


    CD33 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 18 entries
             Monocytes Peripheral Blood
             Peripheral blood-derived hematopoietic stem cells
             Peripheral Blood Monocytes (PB CD14+)   
             cd14+ cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Liver Bud
             Fetal Liver CD34+ Cells   
     
     Umbilical Cord (Extraembryonic Tissues)
             Cord Blood Monocytes (CD14+)   
     
     NULL (Uncategorized)
             Expanded PAX7 cells
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Stem cells from human exfoliated deciduous teeth (family)
    CD33 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD33 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83731

    UniProtKB/Swiss-Prot: CD33_HUMAN, P20138
    Tissue specificity: Monocytic/myeloid lineage cells

        Custom PCR Arrays for CD33
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    QuantiFast Probe-based Assays in human, mouse, rat CD33
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD33

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CD33 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd335 CD33 antigen   --   7 (28.25 cM) 43527456 


    ENSEMBL Gene Tree for CD33 (if available)
    TreeFam Gene Tree for CD33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD33 gene
    SIGLEC82  ENSG000002685002  SIGLEC52  SIGLEC112  SIGLEC62  SIGLEC142  SIGLEC122  MAG2  
    SIGLEC102  SIGLEC72  SIGLEC92  
    9 SIMAP similar genes for CD33 using alignment to 3 protein entries:     CD33_HUMAN (see all proteins):
    SIGLEC14    SIGLEC5    SIGLEC11    SIGLEC10    SIGLEC16    SIGLEC6
    SIGLEC7    SIGLEC8    SIGLEC9

    Find genes that share paralogs with CD33           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CD33
    PGOHUM00000234379 PGOHUM00000234383 PGOHUM00000234742


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CD33 (see all 426)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs13998371,2
    C,F,A--51726355(-) GGGATC/GACAGG 3 -- us2k1 tfbs38Minor allele frequency- G:0.40NA WA CSA EA 367
    rs1173683631,2
    F--51726367(+) GCTACT/CAGAGA 3 -- us2k11Minor allele frequency- C:0.03NA 120
    rs784513591,2
    F--51726380(+) ATGACG/ATGGGA 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1149083821,2
    F--51726436(+) AGGCCG/AGTGCA 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1154664811,2
    C,F--51726513(+) TATTAC/TGTGCC 3 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1467310681,2
    --51726524(+) ACATGC/TTAAAT 3 -- us2k10--------
    rs38266561,2
    C,F,A,H--51726613(+) TATTAA/GTAAGG 3 -- us2k132Minor allele frequency- G:0.38NS EA NA WA CSA 2575
    rs1926329371,2
    C--51726705(+) TCAACC/GGTTTG 3 -- us2k10--------
    rs17103981,2
    C,F,O,A,H--51726911(-) TTGGTT/GCAGTG 3 -- us2k129Minor allele frequency- G:0.36EA NA NS WA CSA 2701
    rs1391269861,2
    C--51726918(+) CCAAAC/TGGCAG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CD33 (51728320 - 51747115 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CD33: --
    Human Gene Mutation Database (HGMD): CD33
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD33
    DNA2.0 Custom Variant and Variant Library Synthesis for CD33

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 159590    OMIM disorders: --

    5 diseases for CD33:    
    About MalaCards
    cd4+/cd56+ hematodermic neoplasm    myeloid sarcoma    myelodysplastic syndromes    acute promyelocytic leukemia
    acute myeloid leukemia

    5 diseases from the University of Copenhagen DISEASES database for CD33:
    Leukemia     Myeloid sarcoma     Lymphoma     Myeloma
    Anemia

    Find genes that share disorders with CD33           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CD33 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia promyelocytic acute 65.2 2 17076651 (1), 20032408 (1)
    myeloid leukemia 63.4 4 8616860 (1), 10690513 (1), 7869759 (1), 11904967 (1)
    leukemia 59.4 7 11328295 (1), 18668307 (1), 20032408 (1), 7559258 (1) (see all 6)
    acute leukemia 56 1 11328295 (1)
    t-all 49.1 1 10891465 (1)
    lymphoblastic leukemia acute 49 2 20032408 (1), 19725224 (1)
    leukemia nonlymphocytic acute 44.6 1 1574028 (1)
    myeloid leukemia chronic 40.5 1 12375643 (1)
    myelodysplastic syndromes 34.3 1 12375643 (1)
    lymphoma 4.36 1 11328295 (1)

    Genetic Association Database (GAD): CD33
    Human Genome Epidemiology (HuGE) Navigator: CD33 (6 documents)

    Export disorders for CD33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CD33 gene, integrated from 10 sources (see all 176):
    (articles sorted by number of sources associating them with CD33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. (PubMed id 3139766)1, 2, 3 Simmons D. and Seed B. (J. Immunol. 1988)
    2. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. (PubMed id 10206955)1, 2, 9 Taylor V.C....Freeman S.D. (J. Biol. Chem. 1999)
    3. A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. (PubMed id 16380601)1, 2, 9 Hernandez-Caselles T....Garcia-Penarrubia P. (J. Leukoc. Biol. 2006)
    4. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. (PubMed id 21460841)1, 4 Naj A.C....Schellenberg G.D. (Nat. Genet. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Coding polymorphisms in CD33 and response to gemtuzumab ozogamicin in pediatric patients with AML: a pilot study. (PubMed id 18615103)1, 4 Lamba J.K....Rubnitz J.E. (Leukemia 2009)
    7. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. (PubMed id 18976728)1, 4 Bertram L....Tanzi R.E. (Am. J. Hum. Genet. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. (PubMed id 11943481)1, 2 Yousef G.M.... Diamandis E.P. (Gene 2002)
    10. Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells. (PubMed id 11320212)1, 2 Vitale C.... Mingari M.C. (Proc. Natl. Acad. Sci. U.S.A. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 945 HGNC: 1659 AceView: CD33 Ensembl:ENSG00000105383 euGenes: HUgn945
    ECgene: CD33 Kegg: 945 H-InvDB: CD33

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CD33 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CD33 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_270

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CD33 gene:
    Search GeneIP for patents involving CD33

    Licensable Technologies for CD33 gene:
    Weizmann Institute:Novel treatment for improving bone-marrow transplantation success
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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