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Aliases for CD33 Gene

Aliases for CD33 Gene

  • CD33 Molecule 2 3
  • Sialic Acid Binding Ig-Like Lectin 3 2 3
  • Sialic Acid-Binding Ig-Like Lectin 3 3 4
  • CD33 Antigen (Gp67) 2 3
  • SIGLEC-3 3 4
  • SIGLEC3 3 4
  • Gp67 3 4
  • Myeloid Cell Surface Antigen CD33 3
  • CD33 Antigen 4
  • P67 3

External Ids for CD33 Gene

Previous GeneCards Identifiers for CD33 Gene

  • GC19P052358
  • GC19P052089
  • GC19P056404
  • GC19P056420
  • GC19P051729
  • GC19P048061

Summaries for CD33 Gene

GeneCards Summary for CD33 Gene

CD33 (CD33 Molecule) is a Protein Coding gene. Diseases associated with CD33 include cd4+/cd56+ hematodermic neoplasm and myeloid sarcoma. Among its related pathways are Hematopoietic cell lineage. GO annotations related to this gene include receptor activity. An important paralog of this gene is SIGLEC5.

UniProtKB/Swiss-Prot for CD33 Gene

  • Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD33 Gene

Genomics for CD33 Gene

Regulatory Elements for CD33 Gene

Genomic Location for CD33 Gene

Start:
51,225,064 bp from pter
End:
51,243,860 bp from pter
Size:
18,797 bases
Orientation:
Plus strand

Genomic View for CD33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD33 Gene

Proteins for CD33 Gene

  • Protein details for CD33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20138-CD33_HUMAN
    Recommended name:
    Myeloid cell surface antigen CD33
    Protein Accession:
    P20138
    Secondary Accessions:
    • B4E3P8
    • C9JEN7
    • F8WAL2
    • Q8TD24

    Protein attributes for CD33 Gene

    Size:
    364 amino acids
    Molecular mass:
    39825 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.

    Alternative splice isoforms for CD33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD33 Gene

Proteomics data for CD33 Gene at MOPED

Post-translational modifications for CD33 Gene

  • Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
  • Glycosylation at Asn100, Asn113, Asn160, Asn209, and Asn230
  • Modification sites at PhosphoSitePlus

Other Protein References for CD33 Gene

Antibody Products

No data available for DME Specific Peptides for CD33 Gene

Domains for CD33 Gene

Gene Families for CD33 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • SIGLEC :Sialic acid binding Ig-like lectins
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD33 Gene

Suggested Antigen Peptide Sequences for CD33 Gene

Graphical View of Domain Structure for InterPro Entry

P20138

UniProtKB/Swiss-Prot:

CD33_HUMAN :
  • P20138
Domain:
  • Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with CD33: view

Function for CD33 Gene

Molecular function for CD33 Gene

GENATLAS Biochemistry: cell differentiation antigen CD33-like (gp67),identified by monoclonal antibodies L4F3,My9,H153,L1B1,expressed in immature cells of the myelomonocytic lineage,sialoadhesin family,myeloid specific inhibitory receptor that may regulate FcgammaRI signal transduction,Ig superfamily
UniProtKB/Swiss-Prot Function: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

Gene Ontology (GO) - Molecular Function for CD33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10611343
GO:0005515 protein binding IPI 10206955
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CD33: view
genes like me logo Genes that share phenotypes with CD33: view

Animal Models for CD33 Gene

MGI Knock Outs for CD33:

Animal Model Products

CRISPR Products

miRNA for CD33 Gene

miRTarBase miRNAs that target CD33

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD33

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD33 Gene

Localization for CD33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD33 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD33 Gene COMPARTMENTS Subcellular localization image for CD33 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 3139766
GO:0005887 integral component of plasma membrane TAS 3139766
GO:0009897 external side of plasma membrane IDA 20660734
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CD33: view

Pathways for CD33 Gene

SuperPathways for CD33 Gene

Superpath Contained pathways
1 Hematopoietic cell lineage
genes like me logo Genes that share pathways with CD33: view

Pathways by source for CD33 Gene

1 KEGG pathway for CD33 Gene

Gene Ontology (GO) - Biological Process for CD33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 10611343
GO:0007267 cell-cell signaling TAS 10611343
GO:0008285 negative regulation of cell proliferation TAS 10611343
genes like me logo Genes that share ontologies with CD33: view

Compounds for CD33 Gene

(1) Drugbank Compounds for CD33 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Gemtuzumab ozogamicin
  • anti-CD33
220578-59-6 target antibody

(7) Novoseek inferred chemical compound relationships for CD33 Gene

Compound -log(P) Hits PubMed IDs
gemtuzumab ozogamicin 95.2 15
calicheamicin 94.2 5
hum 195 86.5 2
nitroblue tetrazolium 33 2
tyrosine 21.3 10
genes like me logo Genes that share compounds with CD33: view

Transcripts for CD33 Gene

Unigene Clusters for CD33 Gene

CD33 molecule:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD33

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3:

Relevant External Links for CD33 Gene

GeneLoc Exon Structure for
CD33
ECgene alternative splicing isoforms for
CD33

Expression for CD33 Gene

mRNA expression in normal human tissues for CD33 Gene

mRNA differential expression in normal tissues according to GTEx for CD33 Gene

This gene is overexpressed in Whole Blood (15.8) and Spleen (7.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD33 Gene

SOURCE GeneReport for Unigene cluster for CD33 Gene Hs.83731

mRNA Expression by UniProt/SwissProt for CD33 Gene

P20138-CD33_HUMAN
Tissue specificity: Monocytic/myeloid lineage cells
genes like me logo Genes that share expressions with CD33: view

In Situ Assay Products

Orthologs for CD33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD33 35
  • 98.4 (n)
  • 96.05 (a)
CD33 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
ManyToMany
LOC508441 35
  • 72.79 (n)
  • 62.9 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
ManyToMany
CD33 35
  • 73.12 (n)
  • 63.01 (a)
mouse
(Mus musculus)
Mammalia Cd33 16
Cd33 36
  • 40 (a)
OneToMany
Siglech 36
  • 49 (a)
OneToMany
Species with no ortholog for CD33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD33 Gene

ENSEMBL:
Gene Tree for CD33 (if available)
TreeFam:
Gene Tree for CD33 (if available)

Paralogs for CD33 Gene

Selected SIMAP similar genes for CD33 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CD33 Gene

genes like me logo Genes that share paralogs with CD33: view

Variants for CD33 Gene

Sequence variations from dbSNP and Humsavar for CD33 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs273621 -- 51,235,678(-) CACTC(A/G)CCGGG splice-donor-variant, downstream-variant-500B
rs273652 -- 51,238,344(-) gtgga(G/T)ccctc intron-variant
rs273653 -- 51,237,584(-) TGTTC(C/T)GGCCT intron-variant
rs988337 - 51,226,335(+) CTGGT(A/C/G)TCTTT reference, missense, intron-variant
rs1051198 -- 51,235,180(+) CAGGA(C/G)TGGTT missense, reference

Relevant External Links for CD33 Gene

HapMap Linkage Disequilibrium report
CD33
Human Gene Mutation Database (HGMD)
CD33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD33 Gene

Disorders for CD33 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CD33 Gene including...

Search for CD33 Gene in MalaCards »

(5) University of Copenhagen DISEASES for CD33 Gene

(14) Novoseek inferred disease relationships for CD33 Gene

Disease -log(P) Hits PubMed IDs
leukemia promyelocytic acute 65.2 2
myeloid leukemia 63.4 4
leukemia 59.4 6
acute leukemia 56 1
t-all 49.1 1

Relevant External Links for CD33

Genetic Association Database (GAD)
CD33
Human Genome Epidemiology (HuGE) Navigator
CD33
genes like me logo Genes that share disorders with CD33: view

No data available for UniProtKB/Swiss-Prot for CD33 Gene

Publications for CD33 Gene

  1. A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. (PMID: 16380601) Hernandez-Caselles T. … Garcia-Penarrubia P. (J. Leukoc. Biol. 2006) 3 4 23
  2. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. (PMID: 10206955) Taylor V.C. … Freeman S.D. (J. Biol. Chem. 1999) 3 4 23
  3. Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. (PMID: 3139766) Simmons D. … Seed B. (J. Immunol. 1988) 2 3 4
  4. Anti-CD33 monoclonal antibodies enhance the cytotoxic effects of cytosine arabinoside and idarubicin on acute myeloid leukemia cells through similarities in their signaling pathways. (PMID: 15676214) Balaian L. … Ball E.D. (Exp. Hematol. 2005) 3 23
  5. Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. (PMID: 11943481) Yousef G.M. … Diamandis E.P. (Gene 2002) 3 4

Products for CD33 Gene

Sources for CD33 Gene

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