Aliases for CD320 Gene
External Ids for CD320 Gene
Previous GeneCards Identifiers for CD320 Gene
This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
GeneCards Summary for CD320 Gene
CD320 (CD320 Molecule) is a Protein Coding gene. Diseases associated with CD320 include methylmalonic aciduria due to transcobalamin receptor defect and omphalocele. Among its related pathways are Metabolism and Infectious disease. GO annotations related to this gene include growth factor activity and cobalamin binding.
UniProtKB/Swiss-Prot for CD320 Gene
Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.