CD320 Gene

Aliases
for CD320 gene

Previous GC identifers: GC19M008274 GC19M008275 GC19M008021

Summaries
for CD320 gene

Genomic Views
for CD320 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_077812.2  

SwitchGear Promoter luciferase reporter plasmid: CD320 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD320

CD320 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M008367:  view genomic region     (about GC identifiers)

Proteins
for CD320 gene

Explore the universe of human proteins at neXtProt for CD320: NX_Q9NPF0

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CD320 (CD320/TCblR/8D6A)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CD320
	GenScript Custom Purified and Recombinant Proteins Services for CD320
	Novus Biologicals CD320 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CD320

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CD320 (CD320/TCblR/8D6A)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CD320
	GenScript Custom Superior Antibodies Services for CD320
	Novus Biologicals CD320 Antibodies
	Search for Antibodies for CD320 at Abcam
	Uscn Antibodies for CD320
	Search ThermoFisher Antibodies for CD320

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CD320
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CD320

Protein Domains /
Families
for CD320 gene

ProtoNet protein and cluster: Q9NPF0

Function
for CD320 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CD320 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD320
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CD320:
		hsa-miR-214 hsa-miR-3194-5p hsa-miR-122 hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: CD320 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD320 (see all 7) OriGene shRNA RFP: CD320 OriGene siRNA: CD320
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD320

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CD320

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD320 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD320 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CD320 (NM_016579)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD320
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD320

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CD320
		Search LifeMap BioReagents cell lines for CD320

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD320

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Cd320)

Pathways & Interactions
for CD320 gene

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

Drugs & Compounds
for CD320 gene

Transcripts
for CD320 gene

Expression
for CD320 gene

CD320 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)			Blood, Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD320 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD320
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD320
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD320

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD320

Orthologs
for CD320 gene

Paralogs
for CD320 gene

Paralogs for CD320 gene

LRP12²  LRP3²  LDLRAD3²  LRP10²  

1 SIMAP similar gene for CD320 using alignment to 3 protein entries:     CD320_HUMAN (see all proteins):

VLDLR

CD320 for paralogs           About GeneDecksing

Genomic Variants
for CD320 gene

10/240 NCBI SNPs in CD320 are shown (see all 240)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs755944281,2		--	8021011(+)	CAGGCC/AAAGGG	2	--	ds5001		3		CSA WA NA	240
rs94261,2	C,F,H,	--	8021187(-)	CTATGG/AAGATC	2	--	ut31 ese3		20		MN NS EA NA WA EU	2733
rs22327881,2	C,F,H,	--	8021247(-)	AACCTC/TGAACC	2	--	ut31 ese3		5		NS EA WA	536
rs66031621,2	C,A	--	8022050(+)	tttttG/Tgagag	2	--	int1 trp3		0	--	--	--	--
rs66031631,2	C,A,	--	8022051(+)	ttttgA/Gagagg	2	--	int1 trp3		0	--	--	--	--
rs1115588021,2		--	8022190(+)	ACCACG/ACCTAG	2	--	int1		1		CSA	2
rs1134677751,2		--	8022462(+)	TAGCTC/TGGATT	2	--	int1		1		CSA	2
rs22327851,2	C,F,A,H,	--	8022653(-)	CCTGTG/AGGGGA	2	--	int1		9		NS EA NA WA	780
rs1119470701,2	C	--	8023005(+)	AATCCC/G/TTGGGG	2	--	spa1		1		CSA	1
rs32149091,2	C,	--	8023111(-)	TTTTTT/-GGGCT	2	--	int1		1		CSA	2

HapMap Linkage Disequilibrium report for CD320 (8367011 - 8373240 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CD320
     3 CNVs: 0507 2238 35689
Human Gene Mutation Database (HGMD): CD320

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing CD320: Birth Defects

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD320

DNA2.0 Custom Variant and Variant Library Synthesis for CD320

Disorders / Diseases
for CD320 gene

Publications
for CD320 gene

PubMed articles for CD320 gene, integrated from 9 sources (see all 24): (articles sorted by number of sources associating them with CD320)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of a human follicular dendritic cell molecule that stimulates germinal center B cell growth. (PubMed id 10727470)^{1, 2, 3, 9} Li L....Choi Y.S. (2000)
2. Positive newborn screen for methylmalonic aciduria id entifies the first mutation in TCblR/CD320, the gene for cellular uptake of tra nscobalamin-bound vitamin B(12). (PubMed id 20524213)^{1, 2} Quadros E.V....Rosenblatt D.S. (2010)
3. The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin. (PubMed id 18779389)^{1, 2} Quadros E.V.... Sequeira J.M. (2009)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
6. The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation. (PubMed id 11418631)^{1, 2} Zhang X.... Choi Y.S. (2001)
7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
8. Expression of CD320 in human B cells in addition to follicular dendritic cells. (PubMed id 19123977)^{1, 9} Cho W....Choe J. (2008)
9. Folate and vitamin B12-related genes and risk for omph alocele. (PubMed id 22116453)¹ Mills J.L....Druschel C.M. (2012)
10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

External Searches for CD320 gene

Genome Databases showing CD320 gene

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Specialized Databases showing CD320 gene

Products
for CD320 gene