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Aliases for CD302 Gene

Aliases for CD302 Gene

  • CD302 Molecule 2 3 5
  • Type I Transmembrane C-Type Lectin Receptor DCL-1 3 4
  • DEC205-Associated C-Type Lectin 1 3 4
  • CD302 Antigen 2 4
  • CLEC13A 3 4
  • DCL1 3 4
  • C-Type Lectin Domain Family 13, Member A 3
  • C-Type Lectin Domain Family 13 Member A 4
  • C-Type Lectin Domain Family 13 2
  • C-Type Lectin BIMLEC 4
  • Member A 2
  • KIAA0022 4
  • BIMLEC 3
  • DCL-1 3

External Ids for CD302 Gene

Previous GeneCards Identifiers for CD302 Gene

  • GC02M160451
  • GC02M160333
  • GC02M160625
  • GC02M152509

Summaries for CD302 Gene

Entrez Gene Summary for CD302 Gene

  • CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008]

GeneCards Summary for CD302 Gene

CD302 (CD302 Molecule) is a Protein Coding gene. Diseases associated with CD302 include hodgkin lymphoma. GO annotations related to this gene include carbohydrate binding.

UniProtKB/Swiss-Prot for CD302 Gene

  • Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.

Gene Wiki entry for CD302 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD302 Gene

Genomics for CD302 Gene

Regulatory Elements for CD302 Gene

Enhancers for CD302 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD302 on UCSC Golden Path with GeneCards custom track

Promoters for CD302 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD302 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD302 Gene

Chromosome:
2
Start:
159,768,628 bp from pter
End:
159,798,255 bp from pter
Size:
29,628 bases
Orientation:
Minus strand

Genomic View for CD302 Gene

Genes around CD302 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD302 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD302 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD302 Gene

Proteins for CD302 Gene

  • Protein details for CD302 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX05-CD302_HUMAN
    Recommended name:
    CD302 antigen
    Protein Accession:
    Q8IX05
    Secondary Accessions:
    • A8K5G4
    • B4E2T9
    • Q15009

    Protein attributes for CD302 Gene

    Size:
    232 amino acids
    Molecular mass:
    26183 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

    Alternative splice isoforms for CD302 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD302 Gene

Proteomics data for CD302 Gene at MOPED

Post-translational modifications for CD302 Gene

Other Protein References for CD302 Gene

Antibody Products

  • R&D Systems Antibodies for CD302 (CD302/CLEC13A)
  • Cloud-Clone Corp. Antibodies for CD302

No data available for DME Specific Peptides for CD302 Gene

Domains & Families for CD302 Gene

Gene Families for CD302 Gene

Protein Domains for CD302 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IX05

UniProtKB/Swiss-Prot:

CD302_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CD302: view

Function for CD302 Gene

Molecular function for CD302 Gene

UniProtKB/Swiss-Prot Function:
Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
genes like me logo Genes that share phenotypes with CD302: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CD302

miRNA for CD302 Gene

miRTarBase miRNAs that target CD302

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD302 Gene

Localization for CD302 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD302 Gene

Membrane; Single-pass type I membrane protein. Cell projection, filopodium. Cytoplasm, cell cortex. Cell projection, microvillus. Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD302 Gene COMPARTMENTS Subcellular localization image for CD302 gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD302 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005902 microvillus IEA --
GO:0030175 filopodium IDA 17947679
genes like me logo Genes that share ontologies with CD302: view

Pathways & Interactions for CD302 Gene

SuperPathways for CD302 Gene

No Data Available

Interacting Proteins for CD302 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000259053%0d%0a9606.ENSP00000376943%0d%0a9606.ENSP00000359375%0d%0a
Selected Interacting proteins: ENSP00000259053 for CD302 Gene via STRING

Gene Ontology (GO) - Biological Process for CD302 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CD302 Gene

Drugs & Compounds for CD302 Gene

No Compound Related Data Available

Transcripts for CD302 Gene

Unigene Clusters for CD302 Gene

CD302 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD302 Gene

No ASD Table

Relevant External Links for CD302 Gene

GeneLoc Exon Structure for
CD302
ECgene alternative splicing isoforms for
CD302

Expression for CD302 Gene

mRNA expression in normal human tissues for CD302 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD302 Gene

This gene is overexpressed in Liver (x6.5) and Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for CD302 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.8) and Lymph node (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD302 Gene



SOURCE GeneReport for Unigene cluster for CD302 Gene Hs.130014

mRNA Expression by UniProt/SwissProt for CD302 Gene

Q8IX05-CD302_HUMAN
Tissue specificity: Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
genes like me logo Genes that share expression patterns with CD302: view

Protein tissue co-expression partners for CD302 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CD302 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD302 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD302 35
  • 90.89 (n)
  • 88.52 (a)
CD302 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD302 35
  • 89.73 (n)
  • 85.31 (a)
CD302 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd302 35
  • 82.58 (n)
  • 76.38 (a)
Cd302 16
Cd302 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd302 35
  • 82.05 (n)
  • 77.4 (a)
lizard
(Anolis carolinensis)
Reptilia CD302 36
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100333685 35
  • 47.69 (n)
  • 35.15 (a)
CABZ01055500.1 36
  • 27 (a)
OneToOne
Species with no ortholog for CD302:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD302 Gene

ENSEMBL:
Gene Tree for CD302 (if available)
TreeFam:
Gene Tree for CD302 (if available)

Paralogs for CD302 Gene

No data available for Paralogs for CD302 Gene

Variants for CD302 Gene

Sequence variations from dbSNP and Humsavar for CD302 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_050101 -

Structural Variations from Database of Genomic Variants (DGV) for CD302 Gene

Variant ID Type Subtype PubMed ID
dgv4351n71 CNV Loss 21882294
nsv875344 CNV Loss 21882294
nsv470497 CNV Loss 18288195
nsv834436 CNV Loss 17160897
esv1001679 CNV Deletion 20482838

Variation tolerance for CD302 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD302 Gene

HapMap Linkage Disequilibrium report
CD302

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD302 Gene

Disorders for CD302 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CD302 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hodgkin lymphoma
  • hodgkin's lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search CD302 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD302

Human Genome Epidemiology (HuGE) Navigator
CD302
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD302
genes like me logo Genes that share disorders with CD302: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD302 Gene

Publications for CD302 Gene

  1. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 67
  2. The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. (PMID: 17947679) Kato M. … Hart D.N. (J. Immunol. 2007) 3 23
  3. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. (PMID: 12824192) Kato M. … Hart D.N.J. (J. Biol. Chem. 2003) 3 23
  4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). (PMID: 7584028) Nomura N. … Tabata S. (DNA Res. 1994) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CD302 Gene

Sources for CD302 Gene

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