Aliases for CD302 Gene
Aliases for CD302 Gene
External Ids for CD302 Gene
- HGNC: 30843
- Entrez Gene: 9936
- Ensembl: ENSG00000241399
- OMIM: 612246
- UniProtKB: Q8IX05
Previous GeneCards Identifiers for CD302 Gene
- GC02M160451
- GC02M160333
- GC02M160625
- GC02M152509
Summaries for CD302 Gene
-
CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008]
GeneCards Summary for CD302 Gene
CD302 (CD302 Molecule) is a Protein Coding gene. Diseases associated with CD302 include Hodgkin Lymphoma. GO annotations related to this gene include carbohydrate binding.
UniProtKB/Swiss-Prot for CD302 Gene
-
Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD302 Gene
Genomics for CD302 Gene
Regulatory Elements for CD302 Gene
Enhancers for CD302 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CD302 on UCSC Golden Path with GeneCards custom track
Promoters for CD302 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around CD302 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CD302 gene promoter:
Regulatory Element Products
Genomic Location for CD302 Gene
- Chromosome:
- 2
- Start:
- 159,768,628 bp from pter
- End:
- 159,798,255 bp from pter
- Size:
- 29,628 bases
- Orientation:
- Minus strand
Genomic View for CD302 Gene
Genes around CD302 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q24.2 by Ensembl
- 2q24.2 by Entrez Gene
- 2q24.2 by HGNC
CD302 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD302 Gene
Proteins for CD302 Gene
-
Protein details for CD302 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IX05-CD302_HUMAN
- Recommended name:
- CD302 antigen
- Protein Accession:
- Q8IX05
- A8K5G4
- B4E2T9
- Q15009
Protein attributes for CD302 Gene
- Size:
- 232 amino acids
- Molecular mass:
- 26183 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.
Protein Expression for CD302 Gene
Post-translational modifications for CD302 Gene
- May be heterogeneously N-glycosylated in some cell types.
- Glycosylation at Asn 109
- Modification sites at PhosphoSitePlus
Other Protein References for CD302 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD302 (CD302/CLEC13A)
-
Custom Antibody ServicesOriGene Antibodies for CD302
- Novus Biologicals Antibodies for CD302
-
Cloud-Clone Corp. Antibodies for CD302
- Invitrogen Antibodies for CD302
- antibodies-online Antibodies for CD302: See all 56
- GeneTex CD302 antibody for CD302
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD302
Protein Products
-
OriGene Purified Proteins for CD302
- Search Origene for MassSpec and Protein Over-expression Lysates for CD302
- Origene Custom Protein Services for CD302
- Sino Biological Cell Lysates for CD302
- Sino Biological Recombinant Proteins for CD302
-
Cloud-Clone Corp. Proteins for CD302
- antibodies-online Proteins for CD302: See all 16
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CD302
Assay Products
No data available for DME Specific Peptides for CD302 Gene
Domains & Families for CD302 Gene
Gene Families for CD302 Gene
Protein Domains for CD302 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD302 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IX05- Domain:
-
- Contains 1 C-type lectin domain.
Function for CD302 Gene
Molecular function for CD302 Gene
- UniProtKB/Swiss-Prot Function:
- Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
Phenotypes for CD302 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CD302
-
ViGene Biosciences lentiviral particle packaged cDNA for CD302 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD302 gene
- Search ViGene Biosciences for CD302
CRISPR Products
-
OriGene CRISPR knockouts for CD302
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD302
- GenScript: Design CRISPR guide RNA sequences for CD302
miRNA for CD302 Gene
- miRTarBase miRNAs that target CD302
miRNA Products
- Search ViGene Biosciences for CD302
Clone Products
- OriGene clones in human for CD302
- OriGene ORF clones in human,mouse,rat for CD302
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD302
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CD302 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD302 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD302 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CD302 Gene
Localization for CD302 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD302 Gene
- Membrane; Single-pass type I membrane protein. Cell projection, filopodium. Cytoplasm, cell cortex. Cell projection, microvillus. Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| endoplasmic reticulum | 1 |
| extracellular | 1 |
| golgi apparatus | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005902 | microvillus | IEA | -- |
| GO:0030175 | filopodium | IDA | 17947679 |
Pathways & Interactions for CD302 Gene
More details on SuperPathways for CD302
No Data Available
Interacting Proteins for CD302 Gene
No data available for Pathways by source and SIGNOR curated interactions for CD302 Gene
Transcripts for CD302 Gene
mRNA/cDNA for CD302 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (253) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CD302
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD302
- GenScript: Design CRISPR guide RNA sequences for CD302
miRNA Products
- Search ViGene Biosciences for CD302
Clone Products
- OriGene clones in human for CD302
- OriGene ORF clones in human,mouse,rat for CD302
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD302
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for CD302 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CD302 Gene
This gene is overexpressed in Liver (x6.5) and Whole Blood (x4.5).
This gene is overexpressed in Peripheral blood mononuclear cells (36.8) and Lymph node (13.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD302 Gene
SOURCE GeneReport for Unigene cluster for CD302 Gene Hs.130014
mRNA Expression by UniProt/SwissProt for CD302 Gene
Q8IX05-CD302_HUMAN
Tissue specificity:
Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
Primer Products
-
OriGene qPCR primer pairs for CD302
-
OriGene qPCR primer pairs and template standards for CD302
Orthologs for CD302 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CD302 35 |
|
||
| CD302 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CD302 35 |
|
||
| CD302 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Cd302 35 |
|
||
| Cd302 16 |
|
||||
| Cd302 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Cd302 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CD302 36 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | LOC100333685 35 |
|
||
| CABZ01055500.1 36 |
|
OneToOne |
- Species with no ortholog for CD302:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CD302 Gene
No data available for Paralogs for CD302 Gene
Variants for CD302 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_050101 | - |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4351n71 | CNV | Loss | 21882294 |
| nsv875344 | CNV | Loss | 21882294 |
| nsv470497 | CNV | Loss | 18288195 |
| nsv834436 | CNV | Loss | 17160897 |
| esv1001679 | CNV | Deletion | 20482838 |
Residual Variation Intolerance Score:
43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.71;
57.41% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CD302 Gene
Disorders for CD302 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hodgkin lymphoma |
|
|
Search CD302 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CD302
No data available for UniProtKB/Swiss-Prot and Genatlas for CD302 Gene
Publications for CD302 Gene
- Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 67
- The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration. (PMID: 17947679) Kato M. … Hart D.N. (J. Immunol. 2007) 3 23
- Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. (PMID: 12824192) Kato M. … Hart D.N.J. (J. Biol. Chem. 2003) 3 23
- Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). (PMID: 7584028) Nomura N. … Tabata S. (DNA Res. 1994) 2 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
Products for CD302 Gene
- R&D Systems Antibodies for CD302 (CD302/CLEC13A)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CD302
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CD302
- Search Origene for MassSpec and Protein Over-expression Lysates for CD302
- Origene Custom Protein Services for CD302
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for CD302
- Browse OriGene Inhibitory RNA Products For CD302
- OriGene qPCR primer pairs for CD302
- OriGene qPCR primer pairs and template standards for CD302
- OriGene CRISPR knockouts for CD302
- OriGene clones in human for CD302
- OriGene ORF clones in human,mouse,rat for CD302
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for CD302
- GenScript Custom Assay Services for CD302
- GenScript Custom overexpressing Cell Line Services for CD302
- GenScript: Design CRISPR guide RNA sequences for CD302
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD302
- Sino Biological Human cDNA Clone for CD302
- Sino Biological Cell Lysates for CD302
- Sino Biological Recombinant Proteins for CD302
- 4000+ Proteins
- Search Sino Biological for antibodies, proteins & pathways
- Protein Production Services
- Transfection Reagents
- Protein A/G/L resins
- Isotyping reagents
- Novus Biologicals Antibodies for CD302
- Novus Biologicals proteins and lysates for CD302
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for CD302
- Cloud-Clone Corp. Proteins for CD302
- Browse Assay Kits at Cloud-Clone Corp.
- Taconic Biosciences Mouse Models for CD302
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for CD302: See all 56
- Search antibodies-online for kits
- antibodies-online Proteins for CD302: See all 16
- Search antibodies-online for peptides
- GeneTex CD302 antibody for CD302
- Search GeneTex for Proteins for CD302
- ViGene Biosciences adenoviral particle packaged cDNA for CD302 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD302 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD302 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD302 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD302 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD302 gene
- Search ViGene Biosciences for CD302
- Search ViGene Biosciences for CD302
- Santa Cruz Biotechnology (SCBT) Antibodies for CD302
- Search Santa Cruz Biotechnology (SCBT) for CD302 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD302
Sources for CD302 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
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- (99) Vector BioLabs
- (100) ESI-BIO
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- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
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- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
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- (149) ENCODE
- (150) ProSci
- (151) Horizon