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Aliases for CD300LG Gene

Aliases for CD300LG Gene

  • CD300 Molecule Like Family Member G 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells 4 3 4
  • CD300 Antigen-Like Family Member G 3 4
  • Nepmucin 2 3
  • TREM-4 3 4
  • CLM-9 3 4
  • TREM4 3 4
  • CLM9 3 4
  • CD300 Molecule-Like Family Member G 2
  • CD300 Antigen Like Family Member G 2
  • CMRF35-Like Molecule 9 3
  • CD300g Antigen 4

External Ids for CD300LG Gene

Previous GeneCards Identifiers for CD300LG Gene

  • GC17P039281
  • GC17P041924
  • GC17P037688

Summaries for CD300LG Gene

Entrez Gene Summary for CD300LG Gene

  • Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300LG Gene

CD300LG (CD300 Molecule Like Family Member G) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. GO annotations related to this gene include IgM binding. An important paralog of this gene is CD300C.

UniProtKB/Swiss-Prot for CD300LG Gene

  • Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

Additional gene information for CD300LG Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LG Gene

Genomics for CD300LG Gene

Regulatory Elements for CD300LG Gene

Enhancers for CD300LG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H043366 1.7 Ensembl ENCODE dbSUPER 10.6 -478.1 -478063 4 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 DHX8 NBR2 HMGN1P29 ASB16-AS1 LINC00910 TMUB2 UBTF ENSG00000267340 PSME3 NBR1
GH17H044344 1.7 FANTOM5 ENCODE dbSUPER 10.6 +500.4 500381 5 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF207 UBTF SLC25A39 MEOX1 C17orf53 RUNDC3A-AS1 TMUB2 MAP3K14-AS1 LSM12 RUNDC3A ASB16-AS1
GH17H043878 1.2 Ensembl ENCODE 11.8 +31.9 31944 1 HDGF RB1 KLF17 SIN3A ZNF2 RAD21 ZEB1 GLIS2 ZNF366 SCRT2 MPP2 CD300LG MPP3 NAGS PYY ENSG00000221044 GC17P043880
GH17H044013 1.2 ENCODE 10.6 +167.9 167924 1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ENSG00000267604 TMEM101 MEOX1 RN7SL507P LINC01180 SMCO4P1 RN7SL405P ENSG00000267788 MPP2 MEIOC
GH17H042963 1.1 ENCODE 10.6 -882.2 -882166 2 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SP3 ZHX2 NKIRAS2 MEOX1 CD300LG STAT3 RPL27 AARSD1 GC17M042976
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD300LG on UCSC Golden Path with GeneCards custom track

Genomic Location for CD300LG Gene

Chromosome:
17
Start:
43,846,777 bp from pter
End:
43,863,639 bp from pter
Size:
16,863 bases
Orientation:
Plus strand

Genomic View for CD300LG Gene

Genes around CD300LG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LG Gene

Proteins for CD300LG Gene

  • Protein details for CD300LG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXG3-CLM9_HUMAN
    Recommended name:
    CMRF35-like molecule 9
    Protein Accession:
    Q6UXG3
    Secondary Accessions:
    • B4DNY5
    • F5H7P9
    • F8W9M3
    • Q8IX38
    • Q8IX39
    • Q8TA95

    Protein attributes for CD300LG Gene

    Size:
    332 amino acids
    Molecular mass:
    36060 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD300LG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD300LG Gene

Post-translational modifications for CD300LG Gene

  • O-glycosylated with sialylated oligosaccharides.
  • Glycosylation at posLast=9696, posLast=137137, posLast=143143, posLast=144144, Thr155, posLast=161161, Thr170, posLast=171171, posLast=177177, posLast=187187, posLast=195195, Ser196, posLast=199199, posLast=201201, Ser202, posLast=207207, Ser208, Ser213, Ser214, Ser222, Thr223, Ser224, posLast=228228, Ser229, and posLast=237237
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD300LG Gene

Domains & Families for CD300LG Gene

Gene Families for CD300LG Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD300LG Gene

Suggested Antigen Peptide Sequences for CD300LG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXG3

UniProtKB/Swiss-Prot:

CLM9_HUMAN :
  • Ig-like V-type domain mediates binding to lymphocyte.
  • Belongs to the CD300 family.
Domain:
  • Ig-like V-type domain mediates binding to lymphocyte.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LG: view

Function for CD300LG Gene

Molecular function for CD300LG Gene

UniProtKB/Swiss-Prot Function:
Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

Phenotypes From GWAS Catalog for CD300LG Gene

Gene Ontology (GO) - Molecular Function for CD300LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001791 IgM binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CD300LG: view

Phenotypes for CD300LG Gene

genes like me logo Genes that share phenotypes with CD300LG: view

Animal Models for CD300LG Gene

MGI Knock Outs for CD300LG:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD300LG

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CD300LG
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for CD300LG (CD300g/Nepmucin)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300LG Gene

Localization for CD300LG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LG Gene

Apical cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein. Note=Transcytoses across the cytoplasm. {ECO:0000250 UniProtKB:Q1ERP8}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300LG gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 3
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD300LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with CD300LG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD300LG Gene

Pathways & Interactions for CD300LG Gene

genes like me logo Genes that share pathways with CD300LG: view

Pathways by source for CD300LG Gene

Gene Ontology (GO) - Biological Process for CD300LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002414 immunoglobulin transcytosis in epithelial cells IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300LG: view

No data available for SIGNOR curated interactions for CD300LG Gene

Drugs & Compounds for CD300LG Gene

(1) Drugs for CD300LG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CD300LG: view

Transcripts for CD300LG Gene

Unigene Clusters for CD300LG Gene

CD300 molecule-like family member g:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CD300LG
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for CD300LG (CD300g/Nepmucin)

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LG Gene

No ASD Table

Relevant External Links for CD300LG Gene

GeneLoc Exon Structure for
CD300LG
ECgene alternative splicing isoforms for
CD300LG

Expression for CD300LG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD300LG Gene

mRNA differential expression in normal tissues according to GTEx for CD300LG Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x13.7), Adipose - Subcutaneous (x11.4), and Breast - Mammary Tissue (x8.6).

Protein differential expression in normal tissues from HIPED for CD300LG Gene

This gene is overexpressed in Urine (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LG Gene



Protein tissue co-expression partners for CD300LG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD300LG Gene:

CD300LG

SOURCE GeneReport for Unigene cluster for CD300LG Gene:

Hs.147313

mRNA Expression by UniProt/SwissProt for CD300LG Gene:

Q6UXG3-CLM9_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and placenta.

Evidence on tissue expression from TISSUES for CD300LG Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with CD300LG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300LG Gene

Orthologs for CD300LG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD300LG 33 34
  • 99 (n)
dog
(Canis familiaris)
Mammalia CD300LG 33 34
  • 78.01 (n)
cow
(Bos Taurus)
Mammalia CD300LG 33 34
  • 73 (n)
rat
(Rattus norvegicus)
Mammalia Cd300lg 33
  • 72.13 (n)
mouse
(Mus musculus)
Mammalia Cd300lg 33 16 34
  • 71.82 (n)
oppossum
(Monodelphis domestica)
Mammalia CD300LG 34
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CD300L-S1 34
  • 27 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 20 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CD300LG (3 of 5) 34
  • 22 (a)
OneToMany
CD300LG (2 of 5) 34
  • 19 (a)
OneToMany
CD300LG (1 of 5) 34
  • 14 (a)
OneToMany
CD300LG (4 of 5) 34
  • 14 (a)
OneToMany
CD300LG (5 of 5) 34
  • 13 (a)
OneToMany
Species where no ortholog for CD300LG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD300LG Gene

ENSEMBL:
Gene Tree for CD300LG (if available)
TreeFam:
Gene Tree for CD300LG (if available)

Paralogs for CD300LG Gene

Paralogs for CD300LG Gene

(2) SIMAP similar genes for CD300LG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD300LG: view

Variants for CD300LG Gene

Sequence variations from dbSNP and Humsavar for CD300LG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000151140 -- 43,849,519(+) TAGGG(A/G)ATAAA intron-variant, downstream-variant-500B
rs1000379453 -- 43,855,138(+) CCTGG(A/G)ACCCC intron-variant, nc-transcript-variant
rs1000386621 -- 43,856,278(+) TGCCT(A/G)ATGGC intron-variant, upstream-variant-2KB
rs1000497665 -- 43,862,061(+) TGCAT(A/G)TTCCA downstream-variant-500B, utr-variant-3-prime
rs1000883395 -- 43,849,163(+) CTTTC(C/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD300LG Gene

Variant ID Type Subtype PubMed ID
esv3640639 CNV gain 21293372
nsv1146669 OTHER inversion 26484159

Variation tolerance for CD300LG Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 43.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD300LG Gene

Human Gene Mutation Database (HGMD)
CD300LG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD300LG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LG Gene

Disorders for CD300LG Gene

Relevant External Links for CD300LG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD300LG

No disorders were found for CD300LG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300LG Gene

Publications for CD300LG Gene

  1. CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium. (PMID: 16876123) Takatsu H … Ohno H (Biochemical and biophysical research communications 2006) 2 3 4 22 60
  2. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. (PMID: 16754720) Umemoto E … Miyasaka M (The Journal of experimental medicine 2006) 2 3 60
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 60
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  5. Expression Depression of CD300LG-γ in Human Pulmonary Carcinoma. (PMID: 26977771) Zhai S … Hu L (Monoclonal antibodies in immunodiagnosis and immunotherapy 2016) 3 60

Products for CD300LG Gene

Sources for CD300LG Gene

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