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Aliases for CD300LG Gene

Aliases for CD300LG Gene

  • CD300 Molecule-Like Family Member G 2 3
  • TREM4 3 4 6
  • CLM9 3 4 6
  • Triggering Receptor Expressed On Myeloid Cells 4 3 4
  • CD300 Antigen Like Family Member G 2 3
  • CD300 Antigen-Like Family Member G 3 4
  • TREM-4 3 4
  • CLM-9 3 4
  • CD300 Molecule Like Family Member G 3
  • CMRF35-Like Molecule 9 3
  • CD300g Antigen 4
  • Nepmucin 2
  • NEPMUCIN 3

External Ids for CD300LG Gene

Summaries for CD300LG Gene

Entrez Gene Summary for CD300LG Gene

  • Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300LG Gene

CD300LG (CD300 Molecule-Like Family Member G) is a Protein Coding gene. An important paralog of this gene is CD300LD.

UniProtKB/Swiss-Prot for CD300LG Gene

  • Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LG Gene

Genomics for CD300LG Gene

Genomic Location for CD300LG Gene

Start:
43,846,777 bp from pter
End:
43,863,629 bp from pter
Size:
16,853 bases
Orientation:
Plus strand

Genomic View for CD300LG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD300LG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LG Gene

Regulatory Elements for CD300LG Gene

Proteins for CD300LG Gene

  • Protein details for CD300LG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXG3-CLM9_HUMAN
    Recommended name:
    CMRF35-like molecule 9
    Protein Accession:
    Q6UXG3
    Secondary Accessions:
    • B4DNY5
    • F5H7P9
    • F8W9M3
    • Q8IX38
    • Q8IX39
    • Q8TA95

    Protein attributes for CD300LG Gene

    Size:
    332 amino acids
    Molecular mass:
    36060 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD300LG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD300LG Gene

Proteomics data for CD300LG Gene at MOPED

Post-translational modifications for CD300LG Gene

  • O-glycosylated with sialylated oligosaccharides.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn96, Thr137, Thr143, Thr144, Thr155, Thr161, Thr170, Thr171, Thr177, Thr187, Thr195, Ser196, Thr199, Thr201, Ser202, Thr207, Ser208, Ser213, Ser214, Ser222, Thr223, Ser224, Thr228, Ser229, and Ser237

No data available for DME Specific Peptides for CD300LG Gene

Domains for CD300LG Gene

Gene Families for CD300LG Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD300LG Gene

UniProtKB/Swiss-Prot:

CLM9_HUMAN
Domain:
  • Ig-like V-type domain mediates binding to lymphocyte.:
    • Q6UXG3
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q6UXG3
Family:
  • Belongs to the CD300 family.:
    • Q6UXG3
genes like me logo Genes that share domains with CD300LG: view

Function for CD300LG Gene

Molecular function for CD300LG Gene

UniProtKB/Swiss-Prot Function: Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

Gene Ontology (GO) - Molecular Function for CD300LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001791 IgM binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CD300LG: view

Phenotypes for CD300LG Gene

MGI mutant phenotypes for CD300LG:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CD300LG: view

Animal Models for CD300LG Gene

MGI Knock Outs for CD300LG:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD300LG Gene

Localization for CD300LG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LG Gene

Apical cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD300LG Gene COMPARTMENTS Subcellular localization image for CD300LG gene
Compartment Confidence
endosome 5
plasma membrane 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD300LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0032585 multivesicular body membrane IEA --
genes like me logo Genes that share ontologies with CD300LG: view

Pathways for CD300LG Gene

SuperPathways for CD300LG Gene

No Data Available

Interacting Proteins for CD300LG Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000321005%0d%0a9606.ENSP00000375478%0d%0a9606.ENSP00000381009%0d%0a
Selected Interacting proteins: ENSP00000321005 Q6UXG3-CLM9_HUMAN for CD300LG Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for CD300LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002414 immunoglobulin transcytosis in epithelial cells IEA --
genes like me logo Genes that share ontologies with CD300LG: view

No data available for Pathways by source for CD300LG Gene

Compounds for CD300LG Gene

(1) HMDB Compounds for CD300LG Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CD300LG: view

Transcripts for CD300LG Gene

Unigene Clusters for CD300LG Gene

CD300 molecule-like family member g:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LG Gene

No ASD Table

Relevant External Links for CD300LG Gene

GeneLoc Exon Structure for
CD300LG
ECgene alternative splicing isoforms for
CD300LG

Expression for CD300LG Gene

mRNA expression in normal human tissues for CD300LG Gene

mRNA differential expression in normal tissues according to GTEx for CD300LG Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (13.7), Adipose - Subcutaneous (11.4), and Breast - Mammary Tissue (8.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD300LG Gene

SOURCE GeneReport for Unigene cluster for CD300LG Gene Hs.147313

mRNA Expression by UniProt/SwissProt for CD300LG Gene

Q6UXG3-CLM9_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and placenta.
genes like me logo Genes that share expressions with CD300LG: view

Orthologs for CD300LG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD300LG 36
  • 99 (n)
  • 97.89 (a)
CD300LG 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD300LG 36
  • 73 (n)
  • 56.99 (a)
CD300LG 37
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD300LG 36
  • 78.01 (n)
  • 69.67 (a)
CD300LG 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd300lg 36
  • 71.82 (n)
  • 61.83 (a)
Cd300lg 16
Cd300lg 37
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD300LG 37
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd300lg 36
  • 72.13 (n)
  • 60.88 (a)
chicken
(Gallus gallus)
Aves CD300L-S1 37
  • 27 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 20 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CD300LG (1 of 5) 37
  • 14 (a)
OneToMany
CD300LG (2 of 5) 37
  • 19 (a)
OneToMany
CD300LG (3 of 5) 37
  • 22 (a)
OneToMany
CD300LG (4 of 5) 37
  • 14 (a)
OneToMany
CD300LG (5 of 5) 37
  • 13 (a)
OneToMany
Species with no ortholog for CD300LG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD300LG Gene

ENSEMBL:
Gene Tree for CD300LG (if available)
TreeFam:
Gene Tree for CD300LG (if available)

Paralogs for CD300LG Gene

Paralogs for CD300LG Gene

Selected SIMAP similar genes for CD300LG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD300LG: view

Variants for CD300LG Gene

Sequence variations from dbSNP and Humsavar for CD300LG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs170767 -- 43,863,513(-) ACAAG(A/C)TAATT utr-variant-3-prime, downstream-variant-500B
rs231543 -- 43,862,992(-) TTACC(A/C)CCACC utr-variant-3-prime
rs737398 -- 43,858,983(-) CCTCG(C/T)ATGGG intron-variant
rs746742 -- 43,858,261(+) GTAGC(A/G)GAGGA downstream-variant-500B, intron-variant, nc-transcript-variant
rs4792921 -- 43,852,739(+) AGGAG(G/T)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD300LG Gene

Variant ID Type Subtype PubMed ID
nsv908265 CNV Gain 21882294

Relevant External Links for CD300LG Gene

HapMap Linkage Disequilibrium report
CD300LG
Human Gene Mutation Database (HGMD)
CD300LG

Disorders for CD300LG Gene

No disorders were found for CD300LG Gene.

No data available for UniProtKB/Swiss-Prot for CD300LG Gene

Publications for CD300LG Gene

  1. CD300 antigen like family member G: a novel Ig receptor like protein exclusively expressed on capillary endothelium. (PMID: 16876123) Takatsu H. … Ohno H. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. (PMID: 16754720) Umemoto E. … Miyasaka M. (J. Exp. Med. 2006) 2 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CD300LG Gene

Sources for CD300LG Gene

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