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Aliases for CD300LG Gene

Aliases for CD300LG Gene

  • CD300 Molecule Like Family Member G 2 3 5
  • Triggering Receptor Expressed On Myeloid Cells 4 3 4
  • CD300 Molecule-Like Family Member G 2 3
  • CD300 Antigen Like Family Member G 2 3
  • CD300 Antigen-Like Family Member G 3 4
  • TREM-4 3 4
  • CLM-9 3 4
  • TREM4 3 4
  • CLM9 3 4
  • CD300g Antigen 4
  • Nepmucin 2
  • NEPMUCIN 3

External Ids for CD300LG Gene

Previous GeneCards Identifiers for CD300LG Gene

  • GC17P039281
  • GC17P041924
  • GC17P037688

Summaries for CD300LG Gene

Entrez Gene Summary for CD300LG Gene

  • Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300LG Gene

CD300LG (CD300 Molecule Like Family Member G) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include IgM binding. An important paralog of this gene is CD300LD.

UniProtKB/Swiss-Prot for CD300LG Gene

  • Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LG Gene

Genomics for CD300LG Gene

Regulatory Elements for CD300LG Gene

Genomic Location for CD300LG Gene

Chromosome:
17
Start:
43,846,777 bp from pter
End:
43,863,639 bp from pter
Size:
16,863 bases
Orientation:
Plus strand

Genomic View for CD300LG Gene

Genes around CD300LG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LG Gene

Proteins for CD300LG Gene

  • Protein details for CD300LG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXG3-CLM9_HUMAN
    Recommended name:
    CMRF35-like molecule 9
    Protein Accession:
    Q6UXG3
    Secondary Accessions:
    • B4DNY5
    • F5H7P9
    • F8W9M3
    • Q8IX38
    • Q8IX39
    • Q8TA95

    Protein attributes for CD300LG Gene

    Size:
    332 amino acids
    Molecular mass:
    36060 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CD300LG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD300LG Gene

Proteomics data for CD300LG Gene at MOPED

Post-translational modifications for CD300LG Gene

  • O-glycosylated with sialylated oligosaccharides.
  • Glycosylation at Asn 96, Thr 137, Thr 143, Thr 144, Thr 155, Thr 161, Thr 170, Thr 171, Thr 177, Thr 187, Thr 195, Ser 196, Thr 199, Thr 201, Ser 202, Thr 207, Ser 208, Ser 213, Ser 214, Ser 222, Thr 223, Ser 224, Thr 228, Ser 229, and Ser 237
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CD300LG (CD300LG/Nepmucin)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CD300LG

No data available for DME Specific Peptides for CD300LG Gene

Domains & Families for CD300LG Gene

Gene Families for CD300LG Gene

Protein Domains for CD300LG Gene

Suggested Antigen Peptide Sequences for CD300LG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXG3

UniProtKB/Swiss-Prot:

CLM9_HUMAN :
  • Ig-like V-type domain mediates binding to lymphocyte.
  • Belongs to the CD300 family.
Domain:
  • Ig-like V-type domain mediates binding to lymphocyte.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LG: view

Function for CD300LG Gene

Molecular function for CD300LG Gene

UniProtKB/Swiss-Prot Function:
Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

Phenotypes for CD300LG Gene

genes like me logo Genes that share phenotypes with CD300LG: view

Animal Models for CD300LG Gene

MGI Knock Outs for CD300LG:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD300LG

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300LG Gene

Localization for CD300LG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LG Gene

Apical cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein. Note=Transcytoses across the cytoplasm. {ECO:0000250 UniProtKB:Q1ERP8}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD300LG Gene COMPARTMENTS Subcellular localization image for CD300LG gene
Compartment Confidence
extracellular 5
plasma membrane 5
endosome 3
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD300LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CD300LG: view

Pathways & Interactions for CD300LG Gene

genes like me logo Genes that share pathways with CD300LG: view

Pathways by source for CD300LG Gene

Interacting Proteins for CD300LG Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000321005%0d%0a9606.ENSP00000375478%0d%0a9606.ENSP00000381009%0d%0a
Selected Interacting proteins: Q6UXG3-CLM9_HUMAN ENSP00000321005 for CD300LG Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for CD300LG Gene

None

No data available for SIGNOR curated interactions for CD300LG Gene

Drugs & Compounds for CD300LG Gene

(1) Drugs for CD300LG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CD300LG: view

Transcripts for CD300LG Gene

Unigene Clusters for CD300LG Gene

CD300 molecule-like family member g:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LG Gene

No ASD Table

Relevant External Links for CD300LG Gene

GeneLoc Exon Structure for
CD300LG
ECgene alternative splicing isoforms for
CD300LG

Expression for CD300LG Gene

mRNA expression in normal human tissues for CD300LG Gene

mRNA differential expression in normal tissues according to GTEx for CD300LG Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x13.7), Adipose - Subcutaneous (x11.4), and Breast - Mammary Tissue (x8.6).

Protein differential expression in normal tissues from HIPED for CD300LG Gene

This gene is overexpressed in Urine (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LG Gene



SOURCE GeneReport for Unigene cluster for CD300LG Gene Hs.147313

mRNA Expression by UniProt/SwissProt for CD300LG Gene

Q6UXG3-CLM9_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and placenta.
genes like me logo Genes that share expression patterns with CD300LG: view

Protein tissue co-expression partners for CD300LG Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CD300LG Gene

Orthologs for CD300LG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD300LG 36
  • 95 (a)
OneToOne
CD300LG 35
  • 99 (n)
  • 97.89 (a)
cow
(Bos Taurus)
Mammalia CD300LG 35
  • 73 (n)
  • 56.99 (a)
CD300LG 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD300LG 36
  • 60 (a)
OneToOne
CD300LG 35
  • 78.01 (n)
  • 69.67 (a)
mouse
(Mus musculus)
Mammalia Cd300lg 16
Cd300lg 36
  • 49 (a)
OneToOne
Cd300lg 35
  • 71.82 (n)
  • 61.83 (a)
oppossum
(Monodelphis domestica)
Mammalia CD300LG 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd300lg 35
  • 72.13 (n)
  • 60.88 (a)
chicken
(Gallus gallus)
Aves CD300L-S1 36
  • 27 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CD300LG (1 of 5) 36
  • 14 (a)
OneToMany
CD300LG (2 of 5) 36
  • 19 (a)
OneToMany
CD300LG (3 of 5) 36
  • 22 (a)
OneToMany
CD300LG (4 of 5) 36
  • 14 (a)
OneToMany
CD300LG (5 of 5) 36
  • 13 (a)
OneToMany
Species with no ortholog for CD300LG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CD300LG Gene

ENSEMBL:
Gene Tree for CD300LG (if available)
TreeFam:
Gene Tree for CD300LG (if available)

Paralogs for CD300LG Gene

Paralogs for CD300LG Gene

(2) SIMAP similar genes for CD300LG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD300LG: view

Variants for CD300LG Gene

Sequence variations from dbSNP and Humsavar for CD300LG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17852267 - 43,853,986(+) AGCTG(A/G)ACTCC nc-transcript-variant, reference, missense
rs12453522 - 43,854,007(+) AGGAC(A/G)CCAGT nc-transcript-variant, reference, missense
rs170767 -- 43,863,513(-) ACAAG(A/C)TAATT utr-variant-3-prime
rs231543 -- 43,862,992(-) TTACC(A/C)CCACC utr-variant-3-prime
rs4793041 -- 43,855,461(+) TGTGG(A/C/G)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD300LG Gene

Variant ID Type Subtype PubMed ID
nsv908265 CNV Gain 21882294

Variation tolerance for CD300LG Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 43.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD300LG Gene

HapMap Linkage Disequilibrium report
CD300LG
Human Gene Mutation Database (HGMD)
CD300LG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LG Gene

Disorders for CD300LG Gene

Relevant External Links for CD300LG

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD300LG

No disorders were found for CD300LG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300LG Gene

Publications for CD300LG Gene

  1. CD300 antigen like family member G: a novel Ig receptor like protein exclusively expressed on capillary endothelium. (PMID: 16876123) Takatsu H. … Ohno H. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 23 67
  2. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. (PMID: 16754720) Umemoto E. … Miyasaka M. (J. Exp. Med. 2006) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Blood pressure levels in male carriers of Arg82Cys in CD300LG. (PMID: 25314291) StA … Kampmann U. (PLoS ONE 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for CD300LG Gene

Sources for CD300LG Gene

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