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Aliases for CD300LF Gene

Aliases for CD300LF Gene

  • CD300 Molecule Like Family Member F 2 3 5
  • Immune Receptor Expressed On Myeloid Cells 1 3 4
  • Immunoglobulin Superfamily Member 13 3 4
  • CD300 Antigen-Like Family Member F 3 4
  • NK Inhibitory Receptor 3 4
  • CD300f 3 4
  • IREM-1 3 4
  • IgSF13 3 4
  • CLM-1 3 4
  • IREM1 3 4
  • CLM1 3 4
  • NKIR 3 4
  • CD300 Molecule-Like Family Member F 2
  • CD300 Antigen Like Family Member F 2
  • Immunoglobin Superfamily Member 13 3
  • Inhibitory Receptor IREM1 3
  • CMRF35-Like Molecule 1 3
  • CD300f Antigen 4
  • LMIR3 3

External Ids for CD300LF Gene

Previous GeneCards Identifiers for CD300LF Gene

  • GC17M070204
  • GC17M072690
  • GC17M068099

Summaries for CD300LF Gene

Entrez Gene Summary for CD300LF Gene

  • This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CD300LF Gene

CD300LF (CD300 Molecule Like Family Member F) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. An important paralog of this gene is CD300LD.

UniProtKB/Swiss-Prot for CD300LF Gene

  • Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation.

Gene Wiki entry for CD300LF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LF Gene

Genomics for CD300LF Gene

Regulatory Elements for CD300LF Gene

Enhancers for CD300LF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F074687 1.7 FANTOM5 Ensembl ENCODE 30.9 +23.7 23658 4.0 HDGF ARID4B SIN3A FEZF1 FOS SP5 MXD4 REST TBX21 KAT8 CD300LF CD300E TMEM104 CD300LD SUMO2 CD300C CD300LB FADS6 NAT9 GRIN2C
GH17F074778 1.4 FANTOM5 ENCODE 19.9 -66.7 -66745 3.5 PKNOX1 ARID4B ZNF48 ZNF143 FOS MXD4 MIER2 REST KAT8 MIER3 CD300LF RAB37 SLC9A3R1 MIR3615 GRIN2C TMEM104 CD300LB CD300A CD300C GGA3
GH17F074635 1.7 FANTOM5 Ensembl ENCODE 16.1 +73.8 73834 8.3 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 SLC30A9 SP5 NFYC MXD4 CD300E CD300C CD300LB RAB37 TMEM104 CD300LF CD300LD ENSG00000236770 MIR3615 SLC9A3R1
GH17F074677 1.1 FANTOM5 Ensembl ENCODE 18.1 +35.0 34959 1.8 NFIL3 ZNF146 GATA3 SMARCA4 POLR2A HLF ZNF652 CD300LF CD300E CD300LD RAB37 GRIN2C KCTD2 LOC105371894
GH17F074631 1.2 FANTOM5 Ensembl ENCODE 16 +80.4 80384 2.6 IKZF1 MLLT1 CEBPG MYC SPI1 CD300E CD300C CD300LB CD300LF CD300LD RAB37 ENSG00000236770 TMEM104 CD300A SLC16A5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD300LF on UCSC Golden Path with GeneCards custom track

Promoters for CD300LF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001641299 459 801

Genomic Location for CD300LF Gene

74,694,308 bp from pter
74,713,059 bp from pter
18,752 bases
Minus strand

Genomic View for CD300LF Gene

Genes around CD300LF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LF Gene

Proteins for CD300LF Gene

  • Protein details for CD300LF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMRF35-like molecule 1
    Protein Accession:
    Secondary Accessions:
    • B2RCL2
    • C9JDN3
    • Q3Y6P0
    • Q6UX24
    • Q7Z6A6
    • Q7Z7I4
    • Q7Z7I5
    • Q8N6D0
    • Q8NAF5

    Protein attributes for CD300LF Gene

    290 amino acids
    Molecular mass:
    32335 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner.

    Three dimensional structures from OCA and Proteopedia for CD300LF Gene

    Alternative splice isoforms for CD300LF Gene

neXtProt entry for CD300LF Gene

Post-translational modifications for CD300LF Gene

No data available for DME Specific Peptides for CD300LF Gene

Domains & Families for CD300LF Gene

Gene Families for CD300LF Gene

Protein Domains for CD300LF Gene

Suggested Antigen Peptide Sequences for CD300LF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LF: view

Function for CD300LF Gene

Molecular function for CD300LF Gene

UniProtKB/Swiss-Prot Function:
Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation.

Gene Ontology (GO) - Molecular Function for CD300LF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005136 interleukin-4 receptor binding ISS --
GO:0097001 ceramide binding IDA 24035150
genes like me logo Genes that share ontologies with CD300LF: view
genes like me logo Genes that share phenotypes with CD300LF: view

Animal Models for CD300LF Gene

MGI Knock Outs for CD300LF:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD300LF

miRNA for CD300LF Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300LF Gene

Localization for CD300LF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LF Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300LF gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD300LF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300LF: view

Pathways & Interactions for CD300LF Gene

genes like me logo Genes that share pathways with CD300LF: view

Pathways by source for CD300LF Gene

Gene Ontology (GO) - Biological Process for CD300LF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0033004 negative regulation of mast cell activation IDA 24035150
GO:0035772 interleukin-13-mediated signaling pathway ISS --
GO:0050776 regulation of immune response TAS --
GO:1902216 positive regulation of interleukin-4-mediated signaling pathway ISS --
genes like me logo Genes that share ontologies with CD300LF: view

No data available for SIGNOR curated interactions for CD300LF Gene

Transcripts for CD300LF Gene

Unigene Clusters for CD300LF Gene

CD300 molecule-like family member f:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LF Gene

No ASD Table

Relevant External Links for CD300LF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD300LF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD300LF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD300LF Gene

This gene is overexpressed in Whole Blood (x35.0) and Spleen (x7.0).

Protein differential expression in normal tissues from HIPED for CD300LF Gene

This gene is overexpressed in Monocytes (35.2) and Peripheral blood mononuclear cells (27.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LF Gene

Protein tissue co-expression partners for CD300LF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD300LF Gene:


SOURCE GeneReport for Unigene cluster for CD300LF Gene:


mRNA Expression by UniProt/SwissProt for CD300LF Gene:

Tissue specificity: Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.
genes like me logo Genes that share expression patterns with CD300LF: view

Primer Products

Orthologs for CD300LF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD300LF 34 35
  • 98.47 (n)
(Canis familiaris)
Mammalia CD300LF 34
  • 74.82 (n)
-- 35
  • 54 (a)
-- 35
  • 44 (a)
-- 35
  • 42 (a)
(Mus musculus)
Mammalia Cd300lf 34 16 35
  • 70.79 (n)
Cd300lh 35
  • 33 (a)
Gm11710 35
  • 33 (a)
Gm11711 35
  • 33 (a)
Cd300ld 35
  • 32 (a)
Gm11709 35
  • 29 (a)
(Bos Taurus)
Mammalia CD300LF 34
  • 68.23 (n)
-- 35
  • 47 (a)
-- 35
  • 41 (a)
-- 35
  • 39 (a)
(Rattus norvegicus)
Mammalia Cd300lf 34
  • 66.9 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
-- 35
  • 40 (a)
-- 35
  • 36 (a)
-- 35
  • 34 (a)
-- 35
  • 30 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
(Gallus gallus)
Aves -- 35
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 37 (a)
-- 35
  • 26 (a)
Species where no ortholog for CD300LF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300LF Gene

Gene Tree for CD300LF (if available)
Gene Tree for CD300LF (if available)

Paralogs for CD300LF Gene

Paralogs for CD300LF Gene

(5) SIMAP similar genes for CD300LF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD300LF: view

Variants for CD300LF Gene

Sequence variations from dbSNP and Humsavar for CD300LF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1037170 -- 74,706,775(+) GACCA(C/T)GGCAG intron-variant
rs1037171 -- 74,706,839(+) AGCCC(A/G)GGTCC intron-variant
rs10512597 -- 74,703,694(+) TAGAA(C/T)ATGCC intron-variant
rs10673641 -- 74,710,952(+) GAGGA(-/GGA)TCACT intron-variant
rs1106939 -- 74,696,619(+) GCCTT(A/C)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD300LF Gene

Variant ID Type Subtype PubMed ID
dgv3282n100 CNV gain 25217958
dgv5768n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372

Variation tolerance for CD300LF Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD300LF Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LF Gene

Disorders for CD300LF Gene

Relevant External Links for CD300LF

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CD300LF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300LF Gene

Publications for CD300LF Gene

  1. IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. (PMID: 15184070) Sui L. … Cao X. (Biochem. Biophys. Res. Commun. 2004) 3 4 22 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  3. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PMID: 20031577) Danik J.S. … Ridker P.M. (Circ Cardiovasc Genet 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64

Products for CD300LF Gene

Sources for CD300LF Gene

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