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Aliases for CD300LF Gene

Aliases for CD300LF Gene

  • CD300 Molecule-Like Family Member F 2 3
  • IgSF13 3 4 6
  • IREM1 3 4 6
  • CLM1 3 4 6
  • Immune Receptor Expressed On Myeloid Cells 1 3 4
  • Immunoglobulin Superfamily Member 13 3 4
  • CD300 Antigen-Like Family Member F 3 4
  • NK Inhibitory Receptor 3 4
  • CD300f 3 4
  • IREM-1 3 4
  • CLM-1 3 4
  • NKIR 3 4
  • CD300 Molecule Like Family Member F 3
  • CD300 Antigen Like Family Member F 2
  • Immunoglobin Superfamily Member 13 3
  • Inhibitory Receptor IREM1 3
  • CMRF35-Like Molecule 1 3
  • CD300f Antigen 4
  • LMIR3 3

External Ids for CD300LF Gene

Previous GeneCards Identifiers for CD300LF Gene

  • GC17M070204
  • GC17M072690
  • GC17M068099

Summaries for CD300LF Gene

Entrez Gene Summary for CD300LF Gene

  • This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CD300LF Gene

CD300LF (CD300 Molecule-Like Family Member F) is a Protein Coding gene. An important paralog of this gene is CD300LG.

UniProtKB/Swiss-Prot for CD300LF Gene

  • Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation.

Gene Wiki entry for CD300LF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LF Gene

Genomics for CD300LF Gene

Regulatory Elements for CD300LF Gene

Genomic Location for CD300LF Gene

74,694,308 bp from pter
74,713,000 bp from pter
18,693 bases
Minus strand

Genomic View for CD300LF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD300LF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LF Gene

Proteins for CD300LF Gene

  • Protein details for CD300LF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMRF35-like molecule 1
    Protein Accession:
    Secondary Accessions:
    • B2RCL2
    • C9JDN3
    • Q3Y6P0
    • Q6UX24
    • Q7Z6A6
    • Q7Z7I4
    • Q7Z7I5
    • Q8N6D0
    • Q8NAF5

    Protein attributes for CD300LF Gene

    290 amino acids
    Molecular mass:
    32335 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner.

    Three dimensional structures from OCA and Proteopedia for CD300LF Gene

    Alternative splice isoforms for CD300LF Gene

neXtProt entry for CD300LF Gene

Proteomics data for CD300LF Gene at MOPED

Post-translational modifications for CD300LF Gene

Antibody Products

  • R&D Systems Antibodies for CD300LF (CD300f/LMIR3)

No data available for DME Specific Peptides for CD300LF Gene

Domains for CD300LF Gene

Gene Families for CD300LF Gene

  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD300LF Gene

Suggested Antigen Peptide Sequences for CD300LF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8TDQ1
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LF: view

Function for CD300LF Gene

Molecular function for CD300LF Gene

UniProtKB/Swiss-Prot Function:
Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation.

Gene Ontology (GO) - Molecular Function for CD300LF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CD300LF: view
genes like me logo Genes that share phenotypes with CD300LF: view

Animal Models for CD300LF Gene

MGI Knock Outs for CD300LF:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD300LF Gene

Localization for CD300LF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LF Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD300LF Gene COMPARTMENTS Subcellular localization image for CD300LF gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD300LF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300LF: view

Pathways for CD300LF Gene

SuperPathways for CD300LF Gene

No Data Available

Interacting Proteins for CD300LF Gene

Gene Ontology (GO) - Biological Process for CD300LF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with CD300LF: view

No data available for Pathways by source for CD300LF Gene

Transcripts for CD300LF Gene

Unigene Clusters for CD300LF Gene

CD300 molecule-like family member f:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD300LF

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LF Gene

No ASD Table

Relevant External Links for CD300LF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD300LF Gene

mRNA expression in normal human tissues for CD300LF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD300LF Gene

This gene is overexpressed in Whole Blood (35.0) and Spleen (7.0).

Protein differential expression in normal tissues for CD300LF Gene

This gene is overexpressed in Monocytes (35.2) and Peripheral blood mononuclear cells (27.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD300LF Gene

SOURCE GeneReport for Unigene cluster for CD300LF Gene Hs.567706

mRNA Expression by UniProt/SwissProt for CD300LF Gene

Tissue specificity: Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.
genes like me logo Genes that share expressions with CD300LF: view

Expression partners for CD300LF Gene

In Situ Assay Products

Orthologs for CD300LF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD300LF 35
  • 68.23 (n)
  • 54.7 (a)
-- 36
  • 47 (a)
-- 36
  • 41 (a)
-- 36
  • 39 (a)
(Canis familiaris)
Mammalia CD300LF 35
  • 74.82 (n)
  • 63.12 (a)
-- 36
  • 54 (a)
-- 36
  • 42 (a)
-- 36
  • 44 (a)
(Mus musculus)
Mammalia Cd300lf 35
  • 70.79 (n)
  • 56.89 (a)
Cd300lf 16
Cd300ld 36
  • 32 (a)
Cd300lf 36
  • 44 (a)
Cd300lh 36
  • 33 (a)
Gm11709 36
  • 29 (a)
Gm11710 36
  • 33 (a)
Gm11711 36
  • 33 (a)
(Pan troglodytes)
Mammalia CD300LF 35
  • 98.47 (n)
  • 97.05 (a)
CD300LF 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Cd300lf 35
  • 66.9 (n)
  • 54.23 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
-- 36
  • 44 (a)
-- 36
  • 36 (a)
-- 36
  • 30 (a)
-- 36
  • 40 (a)
(Gallus gallus)
Aves -- 36
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
-- 36
  • 37 (a)
Species with no ortholog for CD300LF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300LF Gene

Gene Tree for CD300LF (if available)
Gene Tree for CD300LF (if available)

Paralogs for CD300LF Gene

Paralogs for CD300LF Gene

Selected SIMAP similar genes for CD300LF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD300LF: view

Variants for CD300LF Gene

Sequence variations from dbSNP and Humsavar for CD300LF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_027152 -
VAR_039128 -

Structural Variations from Database of Genomic Variants (DGV) for CD300LF Gene

Variant ID Type Subtype PubMed ID
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407

Relevant External Links for CD300LF Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LF Gene

Disorders for CD300LF Gene

(1) University of Copenhagen DISEASES for CD300LF Gene

Relevant External Links for CD300LF

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD300LF: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CD300LF Gene

Publications for CD300LF Gene

  1. IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. (PMID: 15184070) Sui L. … Cao X. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PMID: 20031577) Danik J.S. … Ridker P.M. (Circ Cardiovasc Genet 2009) 3 48

Products for CD300LF Gene

Sources for CD300LF Gene

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