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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CD300LF Gene

protein-coding   GIFtS: 51
GCID: GC17M072690

CD300 Molecule-Like Family Member F

(Previous name: CD300 antigen like family member F)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CD300 Molecule-Like Family Member F1 2     CD300 Antigen-Like Family Member F2 3
CLM12 3 5     NK Inhibitory Receptor2 3
IREM12 3 5     IGSF133 5
CD300 Antigen Like Family Member F1 2     CD300f2
Immune Receptor Expressed On Myeloid Cells 12 3     CD300 Molecule Like Family Member F2
Immunoglobulin Superfamily Member 132 3     CMRF35-Like Molecule 12
CLM-12 3     Immunoglobin Superfamily Member 132
IREM-12 3     Inhibitory Receptor IREM12
IgSF132 3     CD300F3
NKIR2 3     CD300f Antigen3

External Ids:    HGNC: 298831   Entrez Gene: 1467222   Ensembl: ENSG000001860747   OMIM: 6098075   UniProtKB: Q8TDQ13   

Export aliases for CD300LF gene to outside databases

Previous GC identifers: GC17M070204 GC17M068099


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CD300LF Gene:
CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative
regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP (INPP5D; MIM 601582) (Sui et al., 2004 (PubMed
15184070); Alvarez-Errico et al., 2004 (PubMed 15549731)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CD300LF Gene: 
CD300LF (CD300 molecule-like family member f) is a protein-coding gene. Diseases associated with CD300LF include acute monocytic leukemia, and monocytic leukemia. An important paralog of this gene is CD300LG.

UniProtKB/Swiss-Prot: CLM1_HUMAN, Q8TDQ1
Function: Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation

Gene Wiki entry for CD300LF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CD300LF gene promoter:
         GR   ER-alpha   STAT5B   Pax-5   GR-beta   Olf-1   STAT5A   AREB6   GR-alpha   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD300LF promoter sequence
   Search SABiosciences Chromatin IP Primers for CD300LF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD300LF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

CD300LF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD300LF gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M072690:  view genomic region     (about GC identifiers)

Start:
72,690,452 bp from pter      End:
72,709,117 bp from pter
Size:
18,666 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CLM1_HUMAN, Q8TDQ1 (See protein sequence)
Recommended Name: CMRF35-like molecule 1 precursor  
Size: 290 amino acids; 32335 Da
Subunit: Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)
1 PDB 3D structure from and Proteopedia for CD300LF:
2NMS (3D)    
Secondary accessions: B2RCL2 C9JDN3 Q3Y6P0 Q6UX24 Q7Z6A6 Q7Z7I4 Q7Z7I5 Q8N6D0 Q8NAF5
Alternative splicing: 6 isoforms:  Q8TDQ1-1   Q8TDQ1-2   Q8TDQ1-3   Q8TDQ1-4   Q8TDQ1-5   Q8TDQ1-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD300LF: NX_Q8TDQ1

Explore proteomics data for CD300LF at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TDQ1

  • CD300LF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CD300LF Protein Expression
    REFSEQ proteins: NP_620587.2  
    ENSEMBL proteins: 
     ENSP00000327075   ENSP00000463743   ENSP00000301573   ENSP00000462309   ENSP00000464257  
     ENSP00000464223   ENSP00000464610   ENSP00000355294   ENSP00000343751  

    Human Recombinant Protein Products for CD300LF: 
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    Novus Biologicals CD300LF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    CD300LF for ontologies           About GeneDecksing



    CD300LF Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8TDQ1

    ProtoNet protein and cluster: Q8TDQ1

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: CLM1_HUMAN, Q8TDQ1
    Similarity: Belongs to the CD300 family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CD300LF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLM1_HUMAN, Q8TDQ1
    Function: Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CD300LF for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd300lf):
     homeostasis/metabolism  immune system  nervous system  respiratory system 

    CD300LF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CD300LF: Cd300lftm1Toki Cd300lftm1Gne

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CD300LF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CD300LF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CD300LF 
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    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CD300LF:
    hsa-miR-125a-5p hsa-miR-125b hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidCD300LF 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized lentivirus for stable overexpression of CD300LF 
                         Customized lentivirus expression plasmids for stable overexpression of CD300LF 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300LF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD300LF

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CD300LF (Q8TDQ12, 3 ENSP000003270754) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293502, 3, ENSP000003915924MINT-8032556 I2D: score=2 STRING: ENSP00000391592
    INPP5DQ928353, ENSP000003525754I2D: score=1 STRING: ENSP00000352575
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CD300LF (CLM1)

    Search CenterWatch for drugs/clinical trials and news about CD300LF / CLM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CD300LF gene: 
    NM_139018.3  

    Unigene Cluster for CD300LF:

    CD300 molecule-like family member f
    Hs.567706  [show with all ESTs]
    Unigene Representative Sequence: BC028199
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326165(uc002jlg.3 uc010wra.2) ENST00000469092(uc002jlf.3 uc010dfw.3 uc002jli.3)
    ENST00000301573(uc002jlh.3) ENST00000583937 ENST00000464910(uc002jlj.1)
    ENST00000462044 ENST00000581500 ENST00000583544 ENST00000361254 ENST00000343125

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CD300LF
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CD300LF:
    hsa-miR-125a-5p hsa-miR-125b hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidCD300LF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CD300LF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CD300LF
    Sirion Biotech Customized lentivirus for stable overexpression of CD300LF 
                         Customized lentivirus expression plasmids for stable overexpression of CD300LF 
    Primer
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    OriGene qPCR primer pairs and template standards for CD300LF
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD300LF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD300LF

    Additional mRNA sequence: 

    AF251706.1 AF375480.1 AF375481.1 AK092757.1 AK298752.1 AK315165.1 AY303545.1 AY358545.1 
    BC028199.1 DQ153249.1 

    6 DOTS entries:

    DT.100752362  DT.40224781  DT.100020752  DT.100752363  DT.120912093  DT.97836855 

    24/47 AceView cDNA sequences (see all 47):

    NM_139018 AW138945 AI365178 AF375481 AW590572 AI802017 BM682821 AF375480 
    BM924147 CA307972 BI818421 AI970192 BI911496 AI707979 AF251706 CD367917 
    AK092757 BQ073166 AA984871 AX747710 BE218330 AW003259 BI768733 BF062678 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CD300LF expression in normal human tissues (normalized intensities)      CD300LF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCAAAAAA
    CD300LF Expression
    About this image


    CD300LF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen

    See CD300LF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CD300LF

    SOURCE GeneReport for Unigene cluster: Hs.567706

    UniProtKB/Swiss-Prot: CLM1_HUMAN, Q8TDQ1
    Tissue specificity: Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly
    expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary,
    small intestine or colon. Expressed selectively in monocytes and monocyte-related cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CD300LF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CD300LF gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd300lf1 , 5 CD300 antigen like family member F1, 5 70.13(n)1
    56.06(a)1
      11 (80.59 cM)5
    2467461  NM_145634.31  NP_663609.21 
     1151162145 
    chicken
    (Gallus gallus)
    Aves CD300L-S16
    --
    (see all 3)
    --
    24(a)
    24(a)
    (see all 3)
    many → 1
    possible ortholog
    (see all 3)
    18(10690316-10691046)
    18(10693051-10694640)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    36(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(116020650-116030691)
    2(115986797-115996463)
    zebrafish
    (Danio rerio)
    Actinopterygii BX927114.16
    si:dkey-1c7.26
    (see all 5)
    si:dkey-1c7.2
    (see all 5)
    25(a)
    16(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    1(58482375-58483019)
    1(58460908-58465872)


    ENSEMBL Gene Tree for CD300LF (if available)
    TreeFam Gene Tree for CD300LF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CD300LF gene
    CD300LG2  CD300A2  CD300LB2  CD300C2  CD300LD2  CD300E2  
    5 SIMAP similar genes for CD300LF using alignment to 2 protein entries:     CLM1_HUMAN (see all proteins):
    CD300LD    CD300LB    hDV101S1    CD300E    CD300C

    CD300LF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in CD300LF are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0271524
    ----see VAR_0271522 Q R mis40--------
    VAR_0391284
    ----see VAR_0391282 V A mis40--------

    HapMap Linkage Disequilibrium report for CD300LF (72690452 - 72709117 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD300LF:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv33995CNV Loss17666407
    esv2751770CNV Gain17911159

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CD300LF
    DNA2.0 Custom Variant and Variant Library Synthesis for CD300LF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609807    OMIM disorders: --

    7 diseases for CD300LF:    About MalaCards
    acute monocytic leukemia    monocytic leukemia    crohn's disease    brain injury
    psoriasis    leukemia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for CD300LF:
    Acute monocytic leukemia

    CD300LF for disorders           About GeneDecksing

    Genetic Association Database (GAD): CD300LF
    Human Genome Epidemiology (HuGE) Navigator: CD300LF (1 document)

    Export disorders for CD300LF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CD300LF gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with CD300LF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. (PubMed id 15184070)1, 2, 9 Sui L....Cao X. (2004)
    3. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PubMed id 20031577)1, 4 Danik J.S....Ridker P.M. (2009)
    4. IREM-1 is a novel inhibitory receptor expressed by myeloid cells. (PubMed id 15549731)1, 2 Alvarez-Errico D....Lopez-Botet M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. CD300 molecule regulation of human dendritic cell func tions. (PubMed id 23072861)1 Gasiorowski R.E....Clark G.J. (2013)
    9. CD300a and CD300f differentially regulate the MyD88 an d TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines. (PubMed id 22043923)1 Kim E.J....Lee W.H. (2012)
    10. Synthetic peptides containing ITIM-like sequences of I REM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling th rough activation of SHP and/or PI3K. (PubMed id 22288587)1 Lee S.M....Lee W.H. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 146722 HGNC: 29883 AceView: NKIR Ensembl:ENSG00000186074 euGenes: HUgn146722
    ECgene: CD300LF H-InvDB: CD300LF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CD300LF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CD300LF gene:
    Search GeneIP for patents involving CD300LF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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