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CD300LF Gene

protein-coding   GIFtS: 52
GCID: GC17M072690

CD300 Molecule-Like Family Member F

(Previous name: CD300 antigen like family member F)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CD300 Molecule-Like Family Member F1 2     IGSF133 5
CLM12 3 5     CD300 Antigen Like Family Member F1
IREM12 3 5     CD300f2
Immune Receptor Expressed On Myeloid Cells 12 3     LMIR32
Immunoglobulin Superfamily Member 132 3     CD300 Molecule Like Family Member F2
CLM-12 3     CMRF35-Like Molecule 12
IREM-12 3     Immunoglobin Superfamily Member 132
IgSF132 3     Inhibitory Receptor IREM12
NKIR2 3     CD300F3
CD300 Antigen-Like Family Member F2 3     CD300f Antigen3
NK Inhibitory Receptor2 3     

External Ids:    HGNC: 298831   Entrez Gene: 1467222   Ensembl: ENSG000001860747   OMIM: 6098075   UniProtKB: Q8TDQ13   

Export aliases for CD300LF gene to outside databases

Previous GC identifers: GC17M070204 GC17M068099


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CD300LF Gene:
This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with
a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded
protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Jan 2014)

GeneCards Summary for CD300LF Gene:
CD300LF (CD300 molecule-like family member f) is a protein-coding gene. An important paralog of this gene is CD300LG.

UniProtKB/Swiss-Prot: CLM1_HUMAN, Q8TDQ1
Function: Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation

Gene Wiki entry for CD300LF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CD300LF gene promoter:
         GR   ER-alpha   STAT5B   Pax-5   GR-beta   Olf-1   STAT5A   AREB6   GR-alpha   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCD300LF promoter sequence
   Search Chromatin IP Primers for CD300LF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CD300LF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

CD300LF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CD300LF gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M072690:  view genomic region     (about GC identifiers)

Start:
72,690,452 bp from pter      End:
72,709,117 bp from pter
Size:
18,666 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CLM1_HUMAN, Q8TDQ1 (See protein sequence)
Recommended Name: CMRF35-like molecule 1 precursor  
Size: 290 amino acids; 32335 Da
Subunit: Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner
1 PDB 3D structure from and Proteopedia for CD300LF:
2NMS (3D)    
Secondary accessions: B2RCL2 C9JDN3 Q3Y6P0 Q6UX24 Q7Z6A6 Q7Z7I4 Q7Z7I5 Q8N6D0 Q8NAF5
Alternative splicing: 6 isoforms:  Q8TDQ1-1   Q8TDQ1-2   Q8TDQ1-3   Q8TDQ1-4   Q8TDQ1-5   Q8TDQ1-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CD300LF: NX_Q8TDQ1

Explore proteomics data for CD300LF at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine1
  • Glycosylation2 at Asn88
  • Modification sites at PhosphoSitePlus

  • See CD300LF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001276011.1  NP_001276012.1  NP_001276013.1  NP_001276014.1  NP_001276015.1  NP_001276016.1  NP_620587.2  

    ENSEMBL proteins: 
     ENSP00000327075   ENSP00000463743   ENSP00000301573   ENSP00000462309   ENSP00000464257  
     ENSP00000464223   ENSP00000464610   ENSP00000355294   ENSP00000343751  

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CD300LF (2 products) 

     
    antibodies-online peptides for CD300LF

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q8TDQ1

    ProtoNet protein and cluster: Q8TDQ1

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: CLM1_HUMAN, Q8TDQ1
    Similarity: Belongs to the CD300 family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CD300LF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CLM1_HUMAN, Q8TDQ1
    Function: Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CD300LF           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cd300lf):
     hematopoietic system  homeostasis/metabolism  immune system  nervous system  respiratory system 

    Find genes that share phenotypes with CD300LF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CD300LF: Cd300lftm1Toki Cd300lftm1Gne

       genOway: Develop your customized and physiologically relevant rodent model for CD300LF

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CLM1_HUMAN, Q8TDQ1: Cell membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CD300LF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CD300LF
    Interactions:

        Search GeneGlobe Interaction Network for CD300LF

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CD300LF (Q8TDQ12, 3 ENSP000003270754) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293502, 3, ENSP000003915924MINT-8032556 I2D: score=2 STRING: ENSP00000391592
    INPP5DQ928353, ENSP000003525754I2D: score=1 STRING: ENSP00000352575
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--

    Find genes that share ontologies with CD300LF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CD300LF (CLM1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CD300LF gene (7 alternative transcripts): 
    NM_001289082.1  NM_001289083.1  NM_001289084.1  NM_001289085.1  NM_001289086.1  NM_001289087.1  NM_139018.4  

    Unigene Cluster for CD300LF:

    CD300 molecule-like family member f
    Hs.567706  [show with all ESTs]
    Unigene Representative Sequence: BC028199
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326165(uc002jlg.3 uc010wra.2) ENST00000469092(uc002jlf.3 uc010dfw.3 uc002jli.3)
    ENST00000301573(uc002jlh.3) ENST00000583937 ENST00000464910(uc002jlj.1)
    ENST00000462044 ENST00000581500 ENST00000583544 ENST00000361254 ENST00000343125

    miRNA
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    hsa-miR-125a-5p hsa-miR-125b hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidCD300LF 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF251706.1 AF375480.1 AF375481.1 AK092757.1 AK298752.1 AK315165.1 AY303545.1 AY358545.1 
    BC028199.1 DQ153249.1 

    6 DOTS entries:

    DT.100752362  DT.40224781  DT.100020752  DT.100752363  DT.120912093  DT.97836855 

    Selected AceView cDNA sequences (see all 47):

    AW138945 AI365178 NM_139018 AF375480 BM924147 AW003259 AF375481 BE218330 
    CD368538 AA984871 BI911496 AI707979 AX747710 CA307972 BM680508 BC028199 
    AY358545 AK092757 AI970192 BM682821 AF251706 AI802017 BI818421 AW590572 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CD300LF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCAAAAAA
    CD300LF Expression
    About this image


    CD300LF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    CD300LF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CD300LF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567706

    UniProtKB/Swiss-Prot: CLM1_HUMAN, Q8TDQ1
    Tissue specificity: Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly
    expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary,
    small intestine or colon. Expressed selectively in monocytes and monocyte-related cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CD300LF gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cd300lf1 , 5 CD300 antigen like family member F1, 5 70.79(n)1
    56.89(a)1
      11 (80.59 cM)5
    2467461  NM_145634.31  NP_663609.21 
     1151162145 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    26(a)
    1 → many
    18(10693051-10694640)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    37(a)
    26(a)
    many ↔ many
    many ↔ many
    2(116020650-116030691)
    2(115986797-115996463)


    ENSEMBL Gene Tree for CD300LF (if available)
    TreeFam Gene Tree for CD300LF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CD300LF gene
    CD300LG2  CD300A2  CD300LB2  CD300C2  CD300LD2  CD300E2  
    5 SIMAP similar genes for CD300LF using alignment to 2 protein entries:     CLM1_HUMAN (see all proteins):
    CD300LD    CD300LB    hDV101S1    CD300E    CD300C

    Find genes that share paralogs with CD300LF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for CD300LF    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20343101,2,4
    ----see VAR_0271522 mis40--------
    rs354899711,2,4
    ----see VAR_0391282 mis40--------

    HapMap Linkage Disequilibrium report for CD300LF (72690452 - 72709117 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CD300LF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33995CNV Loss17666407
    esv2751770CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CD300LF
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609807    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CD300LF:
    Acute monocytic leukemia

    Find genes that share disorders with CD300LF           About GenesLikeMe

    Genetic Association Database (GAD): CD300LF
    Human Genome Epidemiology (HuGE) Navigator: CD300LF (1 document)

    Export disorders for CD300LF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CD300LF gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with CD300LF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. (PubMed id 15184070)1, 2, 9 Sui L....Cao X. (Biochem. Biophys. Res. Commun. 2004)
    3. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PubMed id 20031577)1, 4 Danik J.S....Ridker P.M. (Circ Cardiovasc Genet 2009)
    4. IREM-1 is a novel inhibitory receptor expressed by myeloid cells. (PubMed id 15549731)1, 2 Alvarez-Errico D....Lopez-Botet M. (Eur. J. Immunol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcI/RI-mediated mast cell activation. (PubMed id 24035150)1 Izawa K....Kitaura J. (J. Allergy Clin. Immunol. 2014)
    9. CD300 molecule regulation of human dendritic cell functions. (PubMed id 23072861)1 Gasiorowski R.E....Clark G.J. (Immunol. Lett. 2013)
    10. Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. (PubMed id 23969696)1 Sabater-Lleal M....O'Donnell C.J. (Circulation 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 146722 HGNC: 29883 AceView: NKIR Ensembl:ENSG00000186074 euGenes: HUgn146722
    ECgene: CD300LF H-InvDB: CD300LF

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CD300LF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CD300LF gene:
    Search GeneIP for patents involving CD300LF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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