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Aliases for CD300LF Gene

Aliases for CD300LF Gene

  • CD300 Molecule Like Family Member F 2 3 5
  • Immune Receptor Expressed On Myeloid Cells 1 3 4
  • Immunoglobulin Superfamily Member 13 3 4
  • CD300 Molecule-Like Family Member F 2 3
  • CD300 Antigen-Like Family Member F 3 4
  • NK Inhibitory Receptor 3 4
  • CD300f 3 4
  • IREM-1 3 4
  • IgSF13 3 4
  • CLM-1 3 4
  • IREM1 3 4
  • CLM1 3 4
  • NKIR 3 4
  • CD300 Antigen Like Family Member F 2
  • Immunoglobin Superfamily Member 13 3
  • Inhibitory Receptor IREM1 3
  • CD300f Antigen 4
  • LMIR3 3

External Ids for CD300LF Gene

Previous GeneCards Identifiers for CD300LF Gene

  • GC17M070204
  • GC17M072690
  • GC17M068099

Summaries for CD300LF Gene

Entrez Gene Summary for CD300LF Gene

  • This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for CD300LF Gene

CD300LF (CD300 Molecule Like Family Member F) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. An important paralog of this gene is CD300LD.

UniProtKB/Swiss-Prot for CD300LF Gene

  • Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation.

Gene Wiki entry for CD300LF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LF Gene

Genomics for CD300LF Gene

Regulatory Elements for CD300LF Gene

Enhancers for CD300LF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD300LF on UCSC Golden Path with GeneCards custom track

Promoters for CD300LF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD300LF on UCSC Golden Path with GeneCards custom track

Genomic Location for CD300LF Gene

Chromosome:
17
Start:
74,694,308 bp from pter
End:
74,713,059 bp from pter
Size:
18,752 bases
Orientation:
Minus strand

Genomic View for CD300LF Gene

Genes around CD300LF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LF Gene

Proteins for CD300LF Gene

  • Protein details for CD300LF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDQ1-CLM1_HUMAN
    Recommended name:
    CMRF35-like molecule 1
    Protein Accession:
    Q8TDQ1
    Secondary Accessions:
    • B2RCL2
    • C9JDN3
    • Q3Y6P0
    • Q6UX24
    • Q7Z6A6
    • Q7Z7I4
    • Q7Z7I5
    • Q8N6D0
    • Q8NAF5

    Protein attributes for CD300LF Gene

    Size:
    290 amino acids
    Molecular mass:
    32335 Da
    Quaternary structure:
    • Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner.

    Three dimensional structures from OCA and Proteopedia for CD300LF Gene

    Alternative splice isoforms for CD300LF Gene

neXtProt entry for CD300LF Gene

Proteomics data for CD300LF Gene at MOPED

Post-translational modifications for CD300LF Gene

Antibody Products

  • R&D Systems Antibodies for CD300LF (CD300f/LMIR3)
  • Abcam antibodies for CD300

No data available for DME Specific Peptides for CD300LF Gene

Domains & Families for CD300LF Gene

Gene Families for CD300LF Gene

Protein Domains for CD300LF Gene

Suggested Antigen Peptide Sequences for CD300LF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDQ1

UniProtKB/Swiss-Prot:

CLM1_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LF: view

Function for CD300LF Gene

Molecular function for CD300LF Gene

UniProtKB/Swiss-Prot Function:
Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation.
genes like me logo Genes that share phenotypes with CD300LF: view

Animal Models for CD300LF Gene

MGI Knock Outs for CD300LF:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD300LF

CRISPR Products

miRNA for CD300LF Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD300LF Gene

Localization for CD300LF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LF Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD300LF Gene COMPARTMENTS Subcellular localization image for CD300LF gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CD300LF Gene

Pathways & Interactions for CD300LF Gene

genes like me logo Genes that share pathways with CD300LF: view

Pathways by source for CD300LF Gene

Interacting Proteins for CD300LF Gene

Gene Ontology (GO) - Biological Process for CD300LF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300LF: view

No data available for SIGNOR curated interactions for CD300LF Gene

Drugs & Compounds for CD300LF Gene

No Compound Related Data Available

Transcripts for CD300LF Gene

Unigene Clusters for CD300LF Gene

CD300 molecule-like family member f:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LF Gene

No ASD Table

Relevant External Links for CD300LF Gene

GeneLoc Exon Structure for
CD300LF
ECgene alternative splicing isoforms for
CD300LF

Expression for CD300LF Gene

mRNA expression in normal human tissues for CD300LF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD300LF Gene

This gene is overexpressed in Whole Blood (x35.0) and Spleen (x7.0).

Protein differential expression in normal tissues from HIPED for CD300LF Gene

This gene is overexpressed in Monocytes (35.2) and Peripheral blood mononuclear cells (27.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LF Gene



SOURCE GeneReport for Unigene cluster for CD300LF Gene Hs.567706

mRNA Expression by UniProt/SwissProt for CD300LF Gene

Q8TDQ1-CLM1_HUMAN
Tissue specificity: Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.
genes like me logo Genes that share expression patterns with CD300LF: view

Protein tissue co-expression partners for CD300LF Gene

- Elite partner

Primer Products

Orthologs for CD300LF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD300LF 35
  • 68.23 (n)
  • 54.7 (a)
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CD300LF 35
  • 74.82 (n)
  • 63.12 (a)
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cd300lf 35
  • 70.79 (n)
  • 56.89 (a)
Cd300lf 16
Cd300ld 36
  • 32 (a)
ManyToMany
Cd300lf 36
  • 44 (a)
ManyToMany
Cd300lh 36
  • 33 (a)
ManyToMany
Gm11709 36
  • 29 (a)
ManyToMany
Gm11710 36
  • 33 (a)
ManyToMany
Gm11711 36
  • 33 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia CD300LF 35
  • 98.47 (n)
  • 97.05 (a)
CD300LF 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd300lf 35
  • 66.9 (n)
  • 54.23 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
Species with no ortholog for CD300LF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300LF Gene

ENSEMBL:
Gene Tree for CD300LF (if available)
TreeFam:
Gene Tree for CD300LF (if available)

Paralogs for CD300LF Gene

Paralogs for CD300LF Gene

(5) SIMAP similar genes for CD300LF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CD300LF: view

Variants for CD300LF Gene

Sequence variations from dbSNP and Humsavar for CD300LF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_027152 -
VAR_039128 -

Structural Variations from Database of Genomic Variants (DGV) for CD300LF Gene

Variant ID Type Subtype PubMed ID
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407

Variation tolerance for CD300LF Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD300LF Gene

Human Gene Mutation Database (HGMD)
CD300LF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LF Gene

Disorders for CD300LF Gene

Relevant External Links for CD300LF

Genetic Association Database (GAD)
CD300LF
Human Genome Epidemiology (HuGE) Navigator
CD300LF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD300LF

No disorders were found for CD300LF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300LF Gene

Publications for CD300LF Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. (PMID: 15184070) Sui L. … Cao X. (Biochem. Biophys. Res. Commun. 2004) 3 23
  3. Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcI/RI-mediated mast cell activation. (PMID: 24035150) Izawa K. … Kitaura J. (J. Allergy Clin. Immunol. 2014) 3
  4. CD300 molecule regulation of human dendritic cell functions. (PMID: 23072861) Gasiorowski R.E. … Clark G.J. (Immunol. Lett. 2013) 3
  5. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. (PMID: 23969696) Sabater-Lleal M. … O'Donnell C.J. (Circulation 2013) 3

Products for CD300LF Gene

Sources for CD300LF Gene

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