CD300LD Gene
protein-coding GIFtS: 34
GCID: GC17M072576
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CD300 molecule-like family member d
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Aliases
for CD300LD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CD300 Molecule-Like Family Member D1 2 | | CD300 Antigen-Like Family Member D2 3 | | CD300D1 2 3 | | CMRF35-Like Molecule 42 | | CMRF35A41 2 3 | | Immune Receptor CD300d2 | | CLM-42 3 | | CD300d Antigen3 | | CMRF35-A42 3 | | |
Export aliases for CD300LD gene to outside databasesPrevious GC identifers: GC17M070088 GC17M067985 |
Summaries
for CD300LD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CD300LD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CD300LD gene promoter:
Bach1 GR Tal-1 GR-beta HNF-4alpha2 HNF-4alpha1 E47 AREB6 RORalpha1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CD300LD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD300LD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1CD300LD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M072576: view genomic region
(about GC identifiers)
Start:
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72,575,504 bp from pter |
End:
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72,588,422 bp from pter |
Size:
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12,919 bases |
Orientation:
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minus strand |
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Proteins
for CD300LD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CLM4_HUMAN, Q6UXZ3 (See
protein sequence)Recommended Name: CMRF35-like molecule 4 precursor Size: 194 amino acids; 21558 Da
Subunit: Forms complexes with the CD300 family members with exception of CD300c
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Cell surface localization requires theITAM-bearing Fc receptor FCER1G to overcome ER retentionExplore the universe of human proteins at neXtProt for CD300LD: NX_Q6UXZ3
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UXZ3
CD300LD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001108624.1
ENSEMBL proteins: ENSP00000364501
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
CD300LD for ontologies About GeneDecksing
CD300LD Antibody Products:
Assay Products for CD300LD: |
Protein
Domains /
Families
for CD300LD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CD300LD for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UXZ3ProtoNet protein and cluster: Q6UXZ3 UniProtKB/Swiss-Prot: CLM4_HUMAN, Q6UXZ3Similarity: Belongs to the CD300 familySimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for CD300LD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD300LD (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD300LD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CD300LD (NM_001115152) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CD300LD | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CD300LD |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- | | GO:0005515 | protein binding |
IPI | -- |
CD300LD for ontologies About GeneDecksing
|
Pathways & Interactions
for CD300LD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CD300LD
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CD300LD (Q6UXZ31 ENSP000003645014) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CD300LD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CD300LD
Search CenterWatch for drugs/clinical trials and news about CD300LD / CLM4
|
Transcripts
for CD300LD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CD300LD gene: NM_001115152.1 Unigene Cluster for CD300LD: CD300 molecule-like family member d Hs.531099 Unigene Representative Sequence: AY3581481 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000375352(uc002jkz.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD300LD (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD300LD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CD300LD (NM_001115152) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CD300LD | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CD300LD |
Additional cDNA sequence: AY358148.1 EF137868.1 1 DOTS entry: DT.101965055
GeneLoc Exon Structure
|
Expression
for CD300LD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CD300LD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CD300LD Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.531099
UniProtKB/Swiss-Prot: CLM4_HUMAN, Q6UXZ3Tissue specificity: Expression seems restricted to cells of myeloid lineage
SABiosciences Expression via Pathway-Focused PCR Array including CD300LD: | Molecular Toxicology PathwayFinder 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD300LD
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CD300LD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD300LD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD300LD |
Orthologs
for CD300LD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CD300LD gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for CD300LD (if available)
TreeFam Gene Tree for CD300LD (if available) |
Paralogs
for CD300LD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CD300LD gene
- CD300LG2 CD300A2 CD300LB2 CD300C2 CD300LF2 CD300E2
4 SIMAP similar genes for CD300LD using alignment to 1 protein entry: CLM4_HUMAN:CD300LF CD300LB CD300E CD300C
CD300LD for paralogs About GeneDecksing
|
Genomic Variants
for CD300LD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CD300LD (72575504 - 72588422 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CD300LD
4 CNVs: 34522 8852 53066 7171 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD300LD |
|
Disorders
/ Diseases
for CD300LD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CD300LD for disorders About GeneDecksing
1  disease for CD300LD: About MalaCardspsoriasis
Export disorders for CD300LD gene to outside databases
|
Publications
for CD300LD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CD300LD gene integrated from 9 sources:
(articles sorted by number of sources associating them with CD300LD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and Characterization of CD300d, a Novel Membe r of the Human CD300 Family of Immune Receptors. (PubMed id 22291008)1, 2, 3 Comas-Casellas E....SayA^s J. (2012)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The CD300 molecules regulate monocyte and dendritic c ell functions. (PubMed id 19592130)1 Clark G.J....Hart D.N. (2009)
- The CD300 family of molecules are evolutionarily sign ificant regulators of leukocyte functions. (PubMed id 19359216)1 Clark G.J....Hart D.N. (2009)
- Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility. (PubMed id 12483297)2 Speckman R.A.... Bowcock A.M. (2003)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for CD300LD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CD300LD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CD300LD gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CD300LD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CD300LD | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CD300LD gene:
Search GeneIP for patents involving CD300LD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CD300LD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CD300LD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CD300LD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CD300LD | | | OriGene Protein Over-expression Lysate for CD300LD | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CD300LD | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CD300LD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CD300LD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CD300LD | | OriGene Custom Protein Services for CD300LD | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CD300LD | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CD300LD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CD300LD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CD300LD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CD300LD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CD300LD |
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 |  |  |  | |
| | | | Search Tocris compounds for CD300LD |
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 | | | CD300LD Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for CD300LD |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CD300LD |
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