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Aliases for CD300LD Gene

Aliases for CD300LD Gene

  • CD300 Molecule Like Family Member D 2 3 5
  • CD300 Antigen-Like Family Member D 3 4
  • CMRF35-A4 3 4
  • CMRF35A4 3 4
  • CD300D 3 4
  • CLM-4 3 4
  • CD300 Molecule-Like Family Member D 2
  • CMRF35-Like Molecule 4 3
  • Immune Receptor CD300d 3
  • CD300d Antigen 4

External Ids for CD300LD Gene

Previous GeneCards Identifiers for CD300LD Gene

  • GC17M070088
  • GC17M072576
  • GC17M067985

Summaries for CD300LD Gene

GeneCards Summary for CD300LD Gene

CD300LD (CD300 Molecule Like Family Member D) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. An important paralog of this gene is CD300LF.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LD Gene

Genomics for CD300LD Gene

Regulatory Elements for CD300LD Gene

Enhancers for CD300LD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G074526 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21 +62.0 61983 7.4 HDGF PKNOX1 FOXA2 ATF1 MLX ARID4B YY1 ZNF207 NFYC REST CD300LB CD300E CD300LD CD300A CD300C CD300LF GPR142 GPRC5C TMEM104 TTYH2
GH17G074568 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +22.7 22727 1.5 TBP ZNF473 ZSCAN4 SIN3A ZNF195 YBX1 GLI4 EGR1 FOS EGR2 CD300E NAT9 CD300C NUP85 CD300LB NT5C CD300LD MGC16275 CASKIN2 RN7SL573P
GH17G074639 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -47.6 -47643 1.7 PKNOX1 GATA3 ARID3A CTBP1 EED NFE2 RELB IKZF2 EGR2 MTA2 CD300E CD300C CD300LB RAB37 TMEM104 CD300LF CD300LD ENSG00000236770 SLC9A3R1 NAT9
GH17G074631 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -39.9 -39933 1.7 IKZF1 CEBPG MLLT1 IKZF2 MYC SPI1 CD300E CD300C CD300LB CD300LF CD300LD RAB37 ENSG00000236770 TMEM104 CD300A SLC16A5
GH17G074635 1.6 FANTOM5 ENCODE dbSUPER 13.2 -44.4 -44393 3.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 TCF12 SLC30A9 SP5 CD300E CD300C CD300LB CD300LF TMEM104 CD300LD RAB37 ENSG00000236770 SLC9A3R1 NAT9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD300LD on UCSC Golden Path with GeneCards custom track

Genomic Location for CD300LD Gene

Chromosome:
17
Start:
74,579,365 bp from pter
End:
74,592,283 bp from pter
Size:
12,919 bases
Orientation:
Minus strand

Genomic View for CD300LD Gene

Genes around CD300LD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LD Gene

Proteins for CD300LD Gene

  • Protein details for CD300LD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXZ3-CLM4_HUMAN
    Recommended name:
    CMRF35-like molecule 4
    Protein Accession:
    Q6UXZ3

    Protein attributes for CD300LD Gene

    Size:
    194 amino acids
    Molecular mass:
    21558 Da
    Quaternary structure:
    • Forms complexes with the CD300 family members with exception of CD300c.

neXtProt entry for CD300LD Gene

Post-translational modifications for CD300LD Gene

Other Protein References for CD300LD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD300LD Gene

Domains & Families for CD300LD Gene

Gene Families for CD300LD Gene

Protein Domains for CD300LD Gene

Suggested Antigen Peptide Sequences for CD300LD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXZ3

UniProtKB/Swiss-Prot:

CLM4_HUMAN :
  • Belongs to the CD300 family.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LD: view

Function for CD300LD Gene

Gene Ontology (GO) - Molecular Function for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD300LD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD300LD Gene

Localization for CD300LD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LD Gene

Cell membrane; Single-pass type I membrane protein. Note=Cell surface localization requires the ITAM-bearing Fc receptor FCER1G to overcome ER retention.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300LD gene
Compartment Confidence
plasma membrane 5
extracellular 3
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300LD: view

Pathways & Interactions for CD300LD Gene

genes like me logo Genes that share pathways with CD300LD: view

Pathways by source for CD300LD Gene

Interacting Proteins for CD300LD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364501%0d%0a9606.ENSP00000291527%0d%0a
Selected Interacting proteins: Q6UXZ3-CLM4_HUMAN ENSP00000364501 for CD300LD Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300LD: view

No data available for SIGNOR curated interactions for CD300LD Gene

Transcripts for CD300LD Gene

mRNA/cDNA for CD300LD Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LD Gene

No ASD Table

Relevant External Links for CD300LD Gene

GeneLoc Exon Structure for
CD300LD
ECgene alternative splicing isoforms for
CD300LD

Expression for CD300LD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD300LD Gene

mRNA differential expression in normal tissues according to GTEx for CD300LD Gene

This gene is overexpressed in Whole Blood (x45.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LD Gene



Protein tissue co-expression partners for CD300LD Gene

NURSA nuclear receptor signaling pathways regulating expression of CD300LD Gene:

CD300LD

SOURCE GeneReport for Unigene cluster for CD300LD Gene:

Hs.531099

mRNA Expression by UniProt/SwissProt for CD300LD Gene:

Q6UXZ3-CLM4_HUMAN
Tissue specificity: Expression seems restricted to cells of myeloid lineage.

Evidence on tissue expression from TISSUES for CD300LD Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with CD300LD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD300LD Gene

Orthologs for CD300LD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD300LD 34 35
  • 98.11 (n)
cow
(Bos Taurus)
Mammalia LOC509881 34
  • 69.93 (n)
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cd300ld 34 35
  • 67.65 (n)
Cd300lh 35
  • 31 (a)
ManyToMany
Gm11710 35
  • 31 (a)
ManyToMany
Gm11711 35
  • 31 (a)
ManyToMany
Gm11709 35
  • 26 (a)
ManyToMany
Cd300lf 35
  • 22 (a)
ManyToMany
Cd300ld5 16
rat
(Rattus norvegicus)
Mammalia Cd300le 34
  • 65.7 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 40 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 17 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 19 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 34 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
Species where no ortholog for CD300LD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300LD Gene

ENSEMBL:
Gene Tree for CD300LD (if available)
TreeFam:
Gene Tree for CD300LD (if available)

Paralogs for CD300LD Gene

Paralogs for CD300LD Gene

(4) SIMAP similar genes for CD300LD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CD300LD: view

Variants for CD300LD Gene

Sequence variations from dbSNP and Humsavar for CD300LD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000238531 -- 74,589,102(+) CAGTT(C/G)ACCCC intron-variant
rs1000650393 -- 74,585,147(+) AAGAT(G/T)CTGAA intron-variant
rs1000765123 -- 74,584,916(+) AAAGG(A/T)CAGTG intron-variant, upstream-variant-2KB, splice-donor-variant
rs1001324339 -- 74,594,035(+) AAACC(A/G)TACAT upstream-variant-2KB, utr-variant-3-prime
rs1001522897 -- 74,583,591(+) ATCTA(C/T)GAGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD300LD Gene

Variant ID Type Subtype PubMed ID
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
nsv517569 CNV gain+loss 19592680

Variation tolerance for CD300LD Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD300LD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD300LD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LD Gene

Disorders for CD300LD Gene

Relevant External Links for CD300LD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD300LD

No disorders were found for CD300LD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300LD Gene

Publications for CD300LD Gene

  1. Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors. (PMID: 22291008) Comas-Casellas E. … Sayos J. (J. Biol. Chem. 2012) 2 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. CD300 molecule regulation of human dendritic cell functions. (PMID: 23072861) Gasiorowski R.E. … Clark G.J. (Immunol. Lett. 2013) 3 64
  4. A secreted protein microarray platform for extracellular protein interaction discovery. (PMID: 21982860) Ramani S.R. … Gonzalez L.C. (Anal. Biochem. 2012) 3 64
  5. The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions. (PMID: 19359216) Clark G.J. … Hart D.N. (Trends Immunol. 2009) 3 64

Products for CD300LD Gene

Sources for CD300LD Gene

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