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Aliases for CD300LD Gene

Aliases for CD300LD Gene

  • CD300 Molecule-Like Family Member D 2 3
  • CD300 Antigen-Like Family Member D 3 4
  • CMRF35-A4 3 4
  • CMRF35A4 3 4
  • CD300D 3 4
  • CLM-4 3 4
  • CMRF35-Like Molecule 4 3
  • Immune Receptor CD300d 3
  • CD300d Antigen 4

External Ids for CD300LD Gene

Summaries for CD300LD Gene

GeneCards Summary for CD300LD Gene

CD300LD (CD300 Molecule-Like Family Member D) is a Protein Coding gene. An important paralog of this gene is CD300LG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LD Gene

Genomics for CD300LD Gene

Genomic Location for CD300LD Gene

Start:
74,579,365 bp from pter
End:
74,592,283 bp from pter
Size:
12,919 bases
Orientation:
Minus strand

Genomic View for CD300LD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD300LD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LD Gene

Regulatory Elements for CD300LD Gene

Proteins for CD300LD Gene

  • Protein details for CD300LD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXZ3-CLM4_HUMAN
    Recommended name:
    CMRF35-like molecule 4
    Protein Accession:
    Q6UXZ3
    Secondary Accessions:

    Protein attributes for CD300LD Gene

    Size:
    194 amino acids
    Molecular mass:
    21558 Da
    Quaternary structure:
    • Forms complexes with the CD300 family members with exception of CD300c.

neXtProt entry for CD300LD Gene

Proteomics data for CD300LD Gene at MOPED

Post-translational modifications for CD300LD Gene

Other Protein References for CD300LD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD300LD Gene

Domains for CD300LD Gene

Gene Families for CD300LD Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD300LD Gene

Suggested Antigen Peptide Sequences for CD300LD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXZ3

UniProtKB/Swiss-Prot:

CLM4_HUMAN
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q6UXZ3
Family:
  • Belongs to the CD300 family.:
    • Q6UXZ3
genes like me logo Genes that share domains with CD300LD: view

Function for CD300LD Gene

Gene Ontology (GO) - Molecular Function for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD300LD: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CD300LD Gene

Localization for CD300LD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LD Gene

Cell membrane; Single-pass type I membrane protein. Note=Cell surface localization requires the ITAM-bearing Fc receptor FCER1G to overcome ER retention.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD300LD Gene COMPARTMENTS Subcellular localization image for CD300LD gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300LD: view

Pathways for CD300LD Gene

SuperPathways for CD300LD Gene

No Data Available

Interacting Proteins for CD300LD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364501%0d%0a9606.ENSP00000291527%0d%0a
Selected Interacting proteins: ENSP00000364501 Q6UXZ3-CLM4_HUMAN for CD300LD Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with CD300LD: view

No data available for Pathways by source for CD300LD Gene

Transcripts for CD300LD Gene

mRNA/cDNA for CD300LD Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LD Gene

No ASD Table

Relevant External Links for CD300LD Gene

GeneLoc Exon Structure for
CD300LD
ECgene alternative splicing isoforms for
CD300LD

Expression for CD300LD Gene

mRNA expression in normal human tissues for CD300LD Gene

mRNA differential expression in normal tissues according to GTEx for CD300LD Gene

This gene is overexpressed in Whole Blood (45.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD300LD Gene

SOURCE GeneReport for Unigene cluster for CD300LD Gene Hs.531099

mRNA Expression by UniProt/SwissProt for CD300LD Gene

Q6UXZ3-CLM4_HUMAN
Tissue specificity: Expression seems restricted to cells of myeloid lineage.
genes like me logo Genes that share expressions with CD300LD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CD300LD Gene

Orthologs for CD300LD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD300LD 35
  • 98.11 (n)
  • 96.39 (a)
CD300LD 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
LOC509881 35
  • 69.93 (n)
  • 57.61 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cd300ld 35
  • 67.65 (n)
  • 56.8 (a)
Cd300ld 16
Cd300ld 36
  • 31 (a)
ManyToMany
Cd300lf 36
  • 22 (a)
ManyToMany
Cd300lh 36
  • 31 (a)
ManyToMany
Gm11709 36
  • 26 (a)
ManyToMany
Gm11710 36
  • 31 (a)
ManyToMany
Gm11711 36
  • 31 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 19 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 17 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd300le 35
  • 65.7 (n)
  • 51.45 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
Species with no ortholog for CD300LD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300LD Gene

ENSEMBL:
Gene Tree for CD300LD (if available)
TreeFam:
Gene Tree for CD300LD (if available)

Paralogs for CD300LD Gene

Paralogs for CD300LD Gene

Selected SIMAP similar genes for CD300LD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CD300LD: view

Variants for CD300LD Gene

Sequence variations from dbSNP and Humsavar for CD300LD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1699587 -- 74,580,182(-) TGGGC(A/T)TAGAG intron-variant
rs1699588 -- 74,579,699(-) accac(A/G)ttgcc downstream-variant-500B
rs1719461 -- 74,582,092(-) aaaac(A/T)ttttt intron-variant
rs1719462 -- 74,580,933(-) TTTGA(A/T)TTTTC intron-variant
rs1719463 -- 74,580,698(-) GAGGT(C/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD300LD Gene

Variant ID Type Subtype PubMed ID
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407

Relevant External Links for CD300LD Gene

HapMap Linkage Disequilibrium report
CD300LD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LD Gene

Disorders for CD300LD Gene

No disorders were found for CD300LD Gene.

No data available for UniProtKB/Swiss-Prot for CD300LD Gene

Publications for CD300LD Gene

  1. Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors. (PMID: 22291008) Comas-Casellas E. … Sayos J. (J. Biol. Chem. 2012) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions. (PMID: 19359216) Clark G.J. … Hart D.N. (Trends Immunol. 2009) 3
  4. The CD300 molecules regulate monocyte and dendritic cell functions. (PMID: 19592130) Clark G.J. … Hart D.N. (Immunobiology 2009) 3
  5. A secreted protein microarray platform for extracellular protein interaction discovery. (PMID: 21982860) Ramani S.R. … Gonzalez L.C. (Anal. Biochem. 2012) 3

Products for CD300LD Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CD300LD
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CD300LD
    • Block miRNA regulation of CD300LD using miScript Target Protectors

    Sources for CD300LD Gene

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