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Aliases for CD300LD Gene

Aliases for CD300LD Gene

  • CD300 Molecule Like Family Member D 2 3 5
  • CD300 Antigen-Like Family Member D 3 4
  • CMRF35-A4 3 4
  • CMRF35A4 3 4
  • CD300D 3 4
  • CLM-4 3 4
  • CD300 Molecule-Like Family Member D 2
  • CMRF35-Like Molecule 4 3
  • Immune Receptor CD300d 3
  • CD300d Antigen 4

External Ids for CD300LD Gene

Previous GeneCards Identifiers for CD300LD Gene

  • GC17M070088
  • GC17M072576
  • GC17M067985

Summaries for CD300LD Gene

GeneCards Summary for CD300LD Gene

CD300LD (CD300 Molecule Like Family Member D) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. An important paralog of this gene is CD300LF.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LD Gene

Genomics for CD300LD Gene

Regulatory Elements for CD300LD Gene

Enhancers for CD300LD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F074568 1.6 FANTOM5 Ensembl ENCODE 14.4 +23.1 23083 2.4 TBP ARNT YBX1 GLI4 FOS EGR2 YY2 CEBPB ZNF645 SP1 LOC100130520 CD300E CD300C NAT9 NUP85 CD300LB NT5C ENSG00000266765 LINC02092 ENSG00000265927
GH17F074635 1.7 FANTOM5 Ensembl ENCODE 13.2 -46.9 -46943 8.3 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 SLC30A9 SP5 NFYC MXD4 CD300E CD300C CD300LB RAB37 TMEM104 CD300LF CD300LD ENSG00000236770 MIR3615 SLC9A3R1
GH17F074687 1.7 FANTOM5 Ensembl ENCODE 11.6 -97.1 -97119 4.0 HDGF ARID4B SIN3A FEZF1 FOS SP5 MXD4 REST TBX21 KAT8 CD300LF CD300E TMEM104 CD300LD SUMO2 CD300C CD300LB FADS6 NAT9 GRIN2C
GH17F074511 1.8 FANTOM5 Ensembl ENCODE 10.5 +78.7 78680 3.3 HDGF PKNOX1 ARNT SIN3A YBX1 FEZF1 ZNF2 ZNF302 CBX5 ZNF416 NUP85 NAT9 NT5C CD300E RN7SL573P LOC100130520 ENSG00000266765 ENSG00000265927 LINC02092 ENSG00000265935
GH17F074519 1.6 FANTOM5 Ensembl ENCODE 10.7 +71.0 70983 3.0 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 GLIS2 SP5 MXD4 MIER2 TBX21 LOC100130520 CD300LB CD300E CD300C CD300LD CD300LF TMEM104 CD300A TTYH2 GC17P074516
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD300LD on UCSC Golden Path with GeneCards custom track

Genomic Location for CD300LD Gene

74,579,365 bp from pter
74,592,283 bp from pter
12,919 bases
Minus strand

Genomic View for CD300LD Gene

Genes around CD300LD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LD Gene

Proteins for CD300LD Gene

  • Protein details for CD300LD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CMRF35-like molecule 4
    Protein Accession:

    Protein attributes for CD300LD Gene

    194 amino acids
    Molecular mass:
    21558 Da
    Quaternary structure:
    • Forms complexes with the CD300 family members with exception of CD300c.

neXtProt entry for CD300LD Gene

Post-translational modifications for CD300LD Gene

Other Protein References for CD300LD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD300LD Gene

Domains & Families for CD300LD Gene

Gene Families for CD300LD Gene

Protein Domains for CD300LD Gene

Suggested Antigen Peptide Sequences for CD300LD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LD: view

Function for CD300LD Gene

Gene Ontology (GO) - Molecular Function for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CD300LD: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD300LD Gene

Localization for CD300LD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LD Gene

Cell membrane; Single-pass type I membrane protein. Note=Cell surface localization requires the ITAM-bearing Fc receptor FCER1G to overcome ER retention.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD300LD gene
Compartment Confidence
plasma membrane 5
extracellular 3
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300LD: view

Pathways & Interactions for CD300LD Gene

genes like me logo Genes that share pathways with CD300LD: view

Pathways by source for CD300LD Gene

Interacting Proteins for CD300LD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000364501 Q6UXZ3-CLM4_HUMAN for CD300LD Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300LD: view

No data available for SIGNOR curated interactions for CD300LD Gene

Transcripts for CD300LD Gene

mRNA/cDNA for CD300LD Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LD Gene

No ASD Table

Relevant External Links for CD300LD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD300LD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CD300LD Gene

mRNA differential expression in normal tissues according to GTEx for CD300LD Gene

This gene is overexpressed in Whole Blood (x45.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LD Gene

Protein tissue co-expression partners for CD300LD Gene

NURSA nuclear receptor signaling pathways regulating expression of CD300LD Gene:


SOURCE GeneReport for Unigene cluster for CD300LD Gene:


mRNA Expression by UniProt/SwissProt for CD300LD Gene:

Tissue specificity: Expression seems restricted to cells of myeloid lineage.
genes like me logo Genes that share expression patterns with CD300LD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for CD300LD Gene

Orthologs for CD300LD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD300LD 34 35
  • 98.11 (n)
(Bos Taurus)
Mammalia LOC509881 34
  • 69.93 (n)
-- 35
  • 41 (a)
-- 35
  • 35 (a)
-- 35
  • 25 (a)
(Mus musculus)
Mammalia Cd300ld 34 35
  • 67.65 (n)
Cd300lh 35
  • 31 (a)
Gm11710 35
  • 31 (a)
Gm11711 35
  • 31 (a)
Gm11709 35
  • 26 (a)
Cd300lf 35
  • 22 (a)
Cd300ld5 16
(Rattus norvegicus)
Mammalia Cd300le 34
  • 65.7 (n)
(Canis familiaris)
Mammalia -- 35
  • 40 (a)
-- 35
  • 39 (a)
-- 35
  • 37 (a)
-- 35
  • 25 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
-- 35
  • 37 (a)
-- 35
  • 25 (a)
-- 35
  • 25 (a)
-- 35
  • 17 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 19 (a)
(Gallus gallus)
Aves -- 35
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 34 (a)
-- 35
  • 23 (a)
Species where no ortholog for CD300LD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300LD Gene

Gene Tree for CD300LD (if available)
Gene Tree for CD300LD (if available)

Paralogs for CD300LD Gene

Paralogs for CD300LD Gene

(4) SIMAP similar genes for CD300LD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CD300LD: view

Variants for CD300LD Gene

Sequence variations from dbSNP and Humsavar for CD300LD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1084667 -- 74,586,192(-) ttccc(A/G)agttt intron-variant
rs1084668 -- 74,586,170(-) cacag(A/G)tgcca intron-variant
rs1084669 -- 74,586,073(-) ttcac(C/T)gcctc intron-variant
rs111294416 -- 74,587,149(+) ATCTC(-/A)AAAAA intron-variant
rs112399930 -- 74,592,074(+) TTTCC(C/T)TGACA intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CD300LD Gene

Variant ID Type Subtype PubMed ID
nsv517569 CNV gain+loss 19592680
esv3641244 CNV gain 21293372
esv3641230 CNV gain 21293372
esv3573820 CNV gain 25503493
esv33995 CNV loss 17666407
esv2761978 CNV gain 21179565
esv2751770 CNV gain 17911159
dgv5774n54 CNV gain 21841781
dgv5768n54 CNV gain 21841781
dgv372n27 CNV gain 19166990
dgv3282n100 CNV gain 25217958

Variation tolerance for CD300LD Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD300LD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LD Gene

Disorders for CD300LD Gene

Relevant External Links for CD300LD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CD300LD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300LD Gene

Publications for CD300LD Gene

  1. Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors. (PMID: 22291008) Comas-Casellas E. … Sayos J. (J. Biol. Chem. 2012) 2 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. CD300 molecule regulation of human dendritic cell functions. (PMID: 23072861) Gasiorowski R.E. … Clark G.J. (Immunol. Lett. 2013) 3 64
  4. A secreted protein microarray platform for extracellular protein interaction discovery. (PMID: 21982860) Ramani S.R. … Gonzalez L.C. (Anal. Biochem. 2012) 3 64
  5. The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions. (PMID: 19359216) Clark G.J. … Hart D.N. (Trends Immunol. 2009) 3 64

Products for CD300LD Gene

Sources for CD300LD Gene

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