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Aliases for CD300LD Gene

Aliases for CD300LD Gene

  • CD300 Molecule Like Family Member D 2 3 5
  • CD300 Molecule-Like Family Member D 2 3
  • CD300 Antigen-Like Family Member D 3 4
  • CMRF35-A4 3 4
  • CMRF35A4 3 4
  • CD300D 3 4
  • CLM-4 3 4
  • Immune Receptor CD300d 3
  • CD300d Antigen 4

External Ids for CD300LD Gene

Previous GeneCards Identifiers for CD300LD Gene

  • GC17M070088
  • GC17M072576
  • GC17M067985

Summaries for CD300LD Gene

GeneCards Summary for CD300LD Gene

CD300LD (CD300 Molecule Like Family Member D) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. An important paralog of this gene is CD300LG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LD Gene

Genomics for CD300LD Gene

Regulatory Elements for CD300LD Gene

Genomic Location for CD300LD Gene

Chromosome:
17
Start:
74,579,365 bp from pter
End:
74,592,283 bp from pter
Size:
12,919 bases
Orientation:
Minus strand

Genomic View for CD300LD Gene

Genes around CD300LD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD300LD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD300LD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LD Gene

Proteins for CD300LD Gene

  • Protein details for CD300LD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXZ3-CLM4_HUMAN
    Recommended name:
    CMRF35-like molecule 4
    Protein Accession:
    Q6UXZ3

    Protein attributes for CD300LD Gene

    Size:
    194 amino acids
    Molecular mass:
    21558 Da
    Quaternary structure:
    • Forms complexes with the CD300 family members with exception of CD300c.

neXtProt entry for CD300LD Gene

Proteomics data for CD300LD Gene at MOPED

Post-translational modifications for CD300LD Gene

Other Protein References for CD300LD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD300LD Gene

Domains & Families for CD300LD Gene

Gene Families for CD300LD Gene

Protein Domains for CD300LD Gene

Suggested Antigen Peptide Sequences for CD300LD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXZ3

UniProtKB/Swiss-Prot:

CLM4_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the CD300 family.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the CD300 family.
genes like me logo Genes that share domains with CD300LD: view

Function for CD300LD Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CD300LD Gene

Localization for CD300LD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LD Gene

Cell membrane; Single-pass type I membrane protein. Note=Cell surface localization requires the ITAM-bearing Fc receptor FCER1G to overcome ER retention.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD300LD Gene COMPARTMENTS Subcellular localization image for CD300LD gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CD300LD Gene

Pathways & Interactions for CD300LD Gene

genes like me logo Genes that share pathways with CD300LD: view

Pathways by source for CD300LD Gene

Interacting Proteins for CD300LD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364501%0d%0a9606.ENSP00000291527%0d%0a
Selected Interacting proteins: Q6UXZ3-CLM4_HUMAN ENSP00000364501 for CD300LD Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for CD300LD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with CD300LD: view

No data available for SIGNOR curated interactions for CD300LD Gene

Drugs & Compounds for CD300LD Gene

No Compound Related Data Available

Transcripts for CD300LD Gene

mRNA/cDNA for CD300LD Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LD Gene

No ASD Table

Relevant External Links for CD300LD Gene

GeneLoc Exon Structure for
CD300LD
ECgene alternative splicing isoforms for
CD300LD

Expression for CD300LD Gene

mRNA expression in normal human tissues for CD300LD Gene

mRNA differential expression in normal tissues according to GTEx for CD300LD Gene

This gene is overexpressed in Whole Blood (x45.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CD300LD Gene



SOURCE GeneReport for Unigene cluster for CD300LD Gene Hs.531099

mRNA Expression by UniProt/SwissProt for CD300LD Gene

Q6UXZ3-CLM4_HUMAN
Tissue specificity: Expression seems restricted to cells of myeloid lineage.
genes like me logo Genes that share expression patterns with CD300LD: view

Protein tissue co-expression partners for CD300LD Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for CD300LD Gene

Orthologs for CD300LD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD300LD 35
  • 98.11 (n)
  • 96.39 (a)
CD300LD 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC509881 35
  • 69.93 (n)
  • 57.61 (a)
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cd300ld 36
  • 31 (a)
ManyToMany
Cd300lf 36
  • 22 (a)
ManyToMany
Cd300lh 36
  • 31 (a)
ManyToMany
Gm11709 36
  • 26 (a)
ManyToMany
Gm11710 36
  • 31 (a)
ManyToMany
Gm11711 36
  • 31 (a)
ManyToMany
Cd300ld 35
  • 67.65 (n)
  • 56.8 (a)
Gm11711 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 19 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 17 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd300le 35
  • 65.7 (n)
  • 51.45 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
Species with no ortholog for CD300LD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300LD Gene

ENSEMBL:
Gene Tree for CD300LD (if available)
TreeFam:
Gene Tree for CD300LD (if available)

Paralogs for CD300LD Gene

Paralogs for CD300LD Gene

(4) SIMAP similar genes for CD300LD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CD300LD: view

Variants for CD300LD Gene

Sequence variations from dbSNP and Humsavar for CD300LD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_059386 -
VAR_059387 -
rs1719461 -- 74,582,092(-) aaaac(A/T)ttttt intron-variant
rs1719462 -- 74,580,933(-) TTTGA(A/T)TTTTC intron-variant
rs1719463 -- 74,580,698(-) GAGGT(C/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD300LD Gene

Variant ID Type Subtype PubMed ID
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407

Variation tolerance for CD300LD Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD300LD Gene

HapMap Linkage Disequilibrium report
CD300LD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD300LD Gene

Disorders for CD300LD Gene

Relevant External Links for CD300LD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD300LD

No disorders were found for CD300LD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CD300LD Gene

Publications for CD300LD Gene

  1. Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors. (PMID: 22291008) Comas-Casellas E. … Sayos J. (J. Biol. Chem. 2012) 2 3 4 67
  2. CD300 molecule regulation of human dendritic cell functions. (PMID: 23072861) Gasiorowski R.E. … Clark G.J. (Immunol. Lett. 2013) 3
  3. A secreted protein microarray platform for extracellular protein interaction discovery. (PMID: 21982860) Ramani S.R. … Gonzalez L.C. (Anal. Biochem. 2012) 3
  4. The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions. (PMID: 19359216) Clark G.J. … Hart D.N. (Trends Immunol. 2009) 3
  5. The CD300 molecules regulate monocyte and dendritic cell functions. (PMID: 19592130) Clark G.J. … Hart D.N. (Immunobiology 2009) 3

Products for CD300LD Gene

Sources for CD300LD Gene

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