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Aliases for CD300LB Gene

Aliases for CD300LB Gene

  • CD300 Molecule-Like Family Member B 2 3
  • Triggering Receptor Expressed On Myeloid Cells 5 2 3 4
  • IREM3 3 4 6
  • TREM5 3 4 6
  • Immune Receptor Expressed On Myeloid Cells 3 3 4
  • CD300 Antigen Like Family Member B 2 3
  • Leukocyte Mono-Ig-Like Receptor 5 3 4
  • CMRF35-A2 3 4
  • CD300b 3 4
  • IREM-3 3 4
  • TREM-5 3 4
  • CLM-7 3 4
  • CLM7 3 4
  • CD300 Antigen-Like Family Member B 4
  • CMRF35-Like Molecule 7 3
  • CD300b Antigen 4
  • EC 1.13.11.6 64
  • EC 6.3.4.3 64
  • CMRF35A2 4
  • LMIR5 4

External Ids for CD300LB Gene

Summaries for CD300LB Gene

Entrez Gene Summary for CD300LB Gene

  • CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CD300LB Gene

CD300LB (CD300 Molecule-Like Family Member B) is a Protein Coding gene. Among its related pathways are Signaling by FGFR. An important paralog of this gene is CD300LG.

UniProtKB/Swiss-Prot for CD300LB Gene

  • Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD300LB Gene

Genomics for CD300LB Gene

Genomic Location for CD300LB Gene

Start:
74,520,755 bp from pter
End:
74,531,474 bp from pter
Size:
10,720 bases
Orientation:
Minus strand

Genomic View for CD300LB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD300LB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD300LB Gene

Regulatory Elements for CD300LB Gene

Proteins for CD300LB Gene

  • Protein details for CD300LB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8K4G0-CLM7_HUMAN
    Recommended name:
    CMRF35-like molecule 7
    Protein Accession:
    A8K4G0
    Secondary Accessions:
    • Q1EG73
    • Q8IX40
    • Q8N6D1

    Protein attributes for CD300LB Gene

    Size:
    201 amino acids
    Molecular mass:
    22689 Da
    Quaternary structure:
    • Interacts with TYROBP, which enhances cell surface expression and activation properties. Interacts with GRB2 in the presence of FYN.
    SequenceCaution:
    • Sequence=AAH28091.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAF83614.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW89170.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CD300LB Gene

Proteomics data for CD300LB Gene at MOPED

Selected DME Specific Peptides for CD300LB Gene

Post-translational modifications for CD300LB Gene

  • Phosphorylation on Tyr-188 by FYN is required for interaction with GRB2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CD300LB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CD300LB Gene

Gene Families for CD300LB Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD300LB Gene

UniProtKB/Swiss-Prot:

CLM7_HUMAN
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • A8K4G0
Family:
  • Belongs to the CD300 family.:
    • A8K4G0
genes like me logo Genes that share domains with CD300LB: view

Function for CD300LB Gene

Molecular function for CD300LB Gene

UniProtKB/Swiss-Prot Function: Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.

Enzyme Numbers (IUBMB) for CD300LB Gene

Gene Ontology (GO) - Molecular Function for CD300LB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CD300LB: view
genes like me logo Genes that share phenotypes with CD300LB: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CD300LB Gene

Localization for CD300LB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD300LB Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD300LB Gene COMPARTMENTS Subcellular localization image for CD300LB gene
Compartment Confidence
plasma membrane 5
extracellular 2
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CD300LB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD300LB: view

Pathways for CD300LB Gene

SuperPathways for CD300LB Gene

Superpath Contained pathways
1 Signaling by FGFR
genes like me logo Genes that share pathways with CD300LB: view

Pathways by source for CD300LB Gene

1 Reactome pathway for CD300LB Gene

Interacting Proteins for CD300LB Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376397%0d%0a9606.ENSP00000262629%0d%0a
Selected Interacting proteins: ENSP00000376397 A8K4G0-CLM7_HUMAN for CD300LB Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CD300LB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with CD300LB: view

Transcripts for CD300LB Gene

mRNA/cDNA for CD300LB Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD300LB Gene

CD300 molecule-like family member b:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD300LB Gene

No ASD Table

Relevant External Links for CD300LB Gene

GeneLoc Exon Structure for
CD300LB
ECgene alternative splicing isoforms for
CD300LB

Expression for CD300LB Gene

mRNA expression in normal human tissues for CD300LB Gene

mRNA differential expression in normal tissues according to GTEx for CD300LB Gene

This gene is overexpressed in Whole Blood (37.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CD300LB Gene

SOURCE GeneReport for Unigene cluster for CD300LB Gene Hs.313343

mRNA Expression by UniProt/SwissProt for CD300LB Gene

A8K4G0-CLM7_HUMAN
Tissue specificity: Expressed exclusively in myeloid lineages.
genes like me logo Genes that share expressions with CD300LB: view

Orthologs for CD300LB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD300LB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD300LB 36
  • 98.51 (n)
  • 98.01 (a)
CD300LB 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD300LB 37
  • 45 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD300LB 37
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd300lb 36
  • 70.67 (n)
  • 57.5 (a)
Cd300lb 16
Cd300lb 37
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 24 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 30 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
-- 37
  • 24 (a)
ManyToMany
-- 37
  • 26 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cd300lb 36
  • 71.83 (n)
  • 60 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 28 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
Species with no ortholog for CD300LB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD300LB Gene

ENSEMBL:
Gene Tree for CD300LB (if available)
TreeFam:
Gene Tree for CD300LB (if available)

Paralogs for CD300LB Gene

Paralogs for CD300LB Gene

Selected SIMAP similar genes for CD300LB Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CD300LB Gene

genes like me logo Genes that share paralogs with CD300LB: view

Variants for CD300LB Gene

Sequence variations from dbSNP and Humsavar for CD300LB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs708601 -- 74,524,459(-) AGGGG(A/C)ACATG intron-variant
rs783249 -- 74,526,564(+) aaaaa(G/T)tagct intron-variant
rs783250 -- 74,527,120(+) ACTCT(C/T)CTTCA intron-variant
rs783251 -- 74,524,548(-) TGCAG(C/T)GGGGT intron-variant
rs783252 -- 74,524,273(-) GGGGC(C/T)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD300LB Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV Duplication 17116639
dgv372n27 CNV Gain 19166990
nsv517569 CNV Gain+Loss 19592680
esv2751770 CNV Gain 17911159
esv33995 CNV Loss 17666407
nsv470600 CNV Loss 18288195

Relevant External Links for CD300LB Gene

HapMap Linkage Disequilibrium report
CD300LB

Disorders for CD300LB Gene

Relevant External Links for CD300LB

Genetic Association Database (GAD)
CD300LB
Human Genome Epidemiology (HuGE) Navigator
CD300LB
genes like me logo Genes that share disorders with CD300LB: view

No data available for UniProtKB/Swiss-Prot for CD300LB Gene

Publications for CD300LB Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways. (PMID: 16920917) Martinez-Barriocanal A. … Sayos J. (J. Immunol. 2006) 3 4
  3. Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. (PMID: 17928527) Yamanishi Y. … Kitamura T. (Blood 2008) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CD300LB Gene

Sources for CD300LB Gene

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